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Derek van der Kooy

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TOP 3
Ryan Ting-A-Kee; Susan R George; Laura E Mercuriano; Hector Vargas-Perez; Derek van der Kooy
Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner.
Mary Rose Bufalino; Brian Deveale; Derek van der Kooy
The asymmetric segregation of damaged proteins is stem cell-type dependent.
Laurie Sellings; Rachel F Tyndale; Bin Zhao; Thomas Dixon-McDougall; Christina Nowak; Schreiber Pereira; Cheng Qian; Derek van der Kooy
Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15.

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All Publications

2013: Ryan Ting-A-Kee; Susan R George; Laura E Mercuriano; Hector Vargas-Perez; Derek van der Kooy
Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner.
Behavioural brain research 2013;247():174-7.
2013: Mary Rose Bufalino; Brian Deveale; Derek van der Kooy
The asymmetric segregation of damaged proteins is stem cell-type dependent.
The Journal of cell biology 2013;201(4):523-30.
2013: Laurie Sellings; Rachel F Tyndale; Bin Zhao; Thomas Dixon-McDougall; Christina Nowak; Schreiber Pereira; Cheng Qian; Derek van der Kooy
Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15.
The European journal of neuroscience 2013;37(5):743-56.
2013: Ryan Ting-A-Kee; Rachel F Tyndale; Amine Bahi; Mary-Rose Bufalino; Jean-Luc Dreyer; Hector Vargas-Perez; Derek van der Kooy
Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation.
The European journal of neuroscience 2013;37(6):996-1003.
2013: Ryan P Salewski; Derek van der Kooy; Josef Buttigieg; Robert A Mitchell; Andras Nagy; Michael G Fehlings
The generation of definitive neural stem cells from PiggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway.
Stem cells and development 2013;22(3):383-96.
2012: Ryan Ting-A-Kee; Derek van der Kooy
The neurobiology of opiate motivation.
Cold Spring Harbor perspectives in medicine 2012;2(10):.
2012: Laura Clarke; Brian G Ballios; Derek van der Kooy
Generation and clonal isolation of retinal stem cells from human embryonic stem cells.
The European journal of neuroscience 2012;36(1):1951-9.
2012: Schreiber Pereira; Derek van der Kooy
Two forms of learning following training to a single odorant in Caenorhabditis elegans AWC neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(26):9035-44.
2012: Radha Chaddah; Laura Clarke; Susan B Runciman; Margot Arntfield; Derek van der Kooy
Clonal neural stem cells from human embryonic stem cell colonies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(23):7771-81.
2012: Brian G Ballios; Laura Clarke; Brenda L K Coles; Molly S Shoichet; Derek van der Kooy
The adult retinal stem cell is a rare cell in the ciliary epithelium whose progeny can differentiate into photoreceptors.
Biology open 2012;1(3):237-46.
2012: Taryn E Grieder; Steven R Laviolette; Bernard Le Foll; Huibing Tan; Olivier George; Susan R George; Derek van der Kooy
Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):3101-6.
2012: Brian DeVeale; Derek van der Kooy; Tomas Babak
Critical evaluation of imprinted gene expression by RNA-Seq: a new perspective.
PLoS genetics 2012;8(3):e1002600.
2011: James W Rowland; Ryan P Salewski; Derek van der Kooy; Eftekhar Eftekharpour; Jason J Lee; Michael G Fehlings
Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization.
Stem cells and development 2011;20(11):1829-45.
2011: Laura Clarke; Derek van der Kooy
The adult mouse dentate gyrus contains populations of committed progenitor cells that are distinct from subependymal zone neural stem cells.
Stem cells (Dayton, Ohio) 2011;29(9):1448-58.
2011: Margot E Arntfield; Derek van der Kooy
β-Cell evolution: How the pancreas borrowed from the brain: The shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship.
BioEssays : news and reviews in molecular, cellular and developmental biology 2011;33(8):582-7.
2011: Tamara Holowacz; Joerg Huelsken; Daniel Dufort; Derek van der Kooy
Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death.
The European journal of neuroscience 2011;33(8):1366-75.
2011: Simon R Smukler; Margot E Arntfield; Rozita Razavi; George Bikopoulos; Phillip Karpowicz; Raewyn Seaberg; Feihan Dai; Simon Lee; Rosemary Ahrens; Paul E Fraser; Michael B Wheeler; Derek van der Kooy
The adult mouse and human pancreas contain rare multipotent stem cells that express insulin.
Cell stem cell 2011;8(3):281-93.
2011: Katherine G Akers; Laura Clarke; Steven A Kushner; Jason P Lerch; Ana T Leslie; Derek van der Kooy; Paul W Frankland
Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice.
Molecular brain 2011;4():29.
2011: Linda Wu; Simon Lam; Robert S Molday; Derek van der Kooy; Rod Bremner; Huibi Cao; Rongqi Duan; Rui Guan; Jim Hu
Subretinal gene delivery using helper-dependent adenoviral vectors.
Cell & bioscience 2011;1(1):15.
2010: Maria Christina Hoffmann; Laurie H L Sellings; Derek van der Kooy
A diacetyl-induced quiescence in young Caenorhabditis elegans.
Behavioural brain research 2010;214(1):12-7.
2010: Jessica E Sturgess; Ryan A Ting-A-Kee; Dominik Podbielski; Laurie Sellings; Jiang-Fan Chen; Derek van der Kooy
Adenosine A1 and A2A receptors are not upstream of caffeine's dopamine D2 receptor-dependent aversive effects and dopamine-independent rewarding effects.
The European journal of neuroscience 2010;32(1):143-54.
2010: Chia Hsun Anthony Lin; Masahiro Tomioka; Schreiber Pereira; Laurie Sellings; Yuichi Iino; Derek van der Kooy
Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisition and memory retrieval.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(23):8001-11.
2010: Tomoyuki Inoue; Brenda L K Coles; Kim Dorval; Rod Bremner; Yasumasa Bessho; Ryoichiro Kageyama; Shinjiro Hino; Masao Matsuoka; Cheryl M Craft; Roderick R McInnes; Francois Tremblay; Glen T Prusky; Derek van der Kooy
Maximizing functional photoreceptor differentiation from adult human retinal stem cells.
Stem cells (Dayton, Ohio) 2010;28(3):489-500.
2010: Brian G Ballios; Michael J Cooke; Derek van der Kooy; Molly S Shoichet
A hydrogel-based stem cell delivery system to treat retinal degenerative diseases.
Biomaterials 2010;31(9):2555-64.
2010: Taryn E Grieder; Laurie Sellings; Hector Vargas-Perez; Ryan Ting-A-Kee; Eric C Siu; Rachel F Tyndale; Derek van der Kooy
Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(4):943-54.
2009: Ronald D McKay; Derek van der Kooy; Thomas P Zwaka; Haifan Lin
Stem cells in 2009.
Cell stem cell 2009;5(5):483-9.
2009: John A Calarco; Simone Superina; David O'Hanlon; Mathieu Gabut; Bushra Raj; Qun Pan; Ursula Skalska; Laura Clarke; Danielle Gelinas; Derek van der Kooy; Mei Zhen; Brian Ciruna; Benjamin J Blencowe
Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein.
Cell 2009;138(5):898-910.
2009: Laura Clarke; Derek van der Kooy
A safer stem cell: inducing pluripotency.
Nature medicine 2009;15(9):1001-2.
2009: Laura Clarke; Derek van der Kooy
Low oxygen enhances primitive and definitive neural stem cell colony formation by inhibiting distinct cell death pathways.
Stem cells (Dayton, Ohio) 2009;27(8):1879-86.
2009: Phillip Karpowicz; Milena Pellikka; Evelyn Chea; Dorothea Godt; Ulrich Tepass; Derek van der Kooy
The germline stem cells of Drosophila melanogaster partition DNA non-randomly.
European journal of cell biology 2009;88(7):397-408.
2009: Hector Vargas-Perez; Ryan Ting-A Kee; Christine H Walton; D Micah Hansen; Rozita Razavi; Laura Clarke; Mary Rose Bufalino; David Allison; Scott C Steffensen; Derek van der Kooy
Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats.
Science (New York, N.Y.) 2009;324(5935):1732-4.
2009: Hector Vargas-Perez; Ryan Ting-A-Kee; Derek van der Kooy
Different neural systems mediate morphine reward and its spontaneous withdrawal aversion.
The European journal of neuroscience 2009;29(10):2029-34.
2009: Phillip Karpowicz; Sandrine Willaime-Morawek; Laurent Balenci; Brian DeVeale; Tomoyuki Inoue; Derek van der Kooy
E-Cadherin regulates neural stem cell self-renewal.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(12):3885-96.
2009: Ryan Ting-A-Kee; Colleen Dockstader; Andrew Heinmiller; Taryn Grieder; Derek van der Kooy
GABA(A) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol.
The European journal of neuroscience 2009;29(6):1235-44.
2009: Wado Akamatsu; Brian DeVeale; Hideyuki Okano; Austin J Cooney; Derek van der Kooy
Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(7):2113-24.
2009: Andrew Heinmiller; Ryan Ting-A-Kee; Hector Vargas-Perez; Andrew Yeh; Derek van der Kooy
Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward.
Behavioral neuroscience 2009;123(1):145-55.
2008: Tomas Babak; Brian Deveale; Christopher Armour; Christopher Raymond; Michele A Cleary; Derek van der Kooy; Jason M Johnson; Lee P Lim
Global survey of genomic imprinting by transcriptome sequencing.
Current biology : CB 2008;18(22):1735-41.
2008: David Tsui; Derek van der Kooy
Serotonin mediates a learned increase in attraction to high concentrations of benzaldehyde in aged C. elegans.
Learning & memory (Cold Spring Harbor, N.Y.) 2008;15(11):844-55.
2008: Brenda L K Coles-Takabe; Ian Brain; Kelly A Purpura; Phillip Karpowicz; Peter W Zandstra; Cindi M Morshead; Derek van der Kooy
Don't look: growing clonal versus nonclonal neural stem cell colonies.
Stem cells (Dayton, Ohio) 2008;26(11):2938-44.
2008: Kimiko Deguchi; Johanna M Clewing; Leah I Elizondo; Ryuki Hirano; Cheng Huang; Kunho Choi; Emily A Sloan; Thomas Lücke; Katja M Marwedel; Ralph D Powell; Karen Santa Cruz; Sandrine Willaime-Morawek; Ken Inoue; Shu Lou; Jennifer Northrop; Yonehiro Kanemura; Derek van der Kooy; Hideyuki Okano; Dawna L Armstrong; Cornelius F Boerkoel
Neurologic phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1.
Journal of neuropathology and experimental neurology 2008;67(6):565-77.
2008: Sandrine Willaime-Morawek; Derek van der Kooy
Cortex- and striatum- derived neural stem cells produce distinct progeny in the olfactory bulb and striatum.
The European journal of neuroscience 2008;27(9):2354-62.
2007: Hong Liu; Shunbin Xu; Yaping Wang; Chantal J Mazerolle; Sherry Thurig; Brenda L K Coles; Jian-Ching Ren; Makoto M Taketo; Derek van der Kooy; Valerie A Wallace
Ciliary margin transdifferentiation from neural retina is controlled by canonical Wnt signaling.
Developmental biology 2007;308(1):54-67.
2007: Hector Vargas-Perez; Ryan A Ting-A-Kee; Andrew Heinmiller; Jessica E Sturgess; Derek van der Kooy
A test of the opponent-process theory of motivation using lesions that selectively block morphine reward.
The European journal of neuroscience 2007;25(12):3713-8.
2007: Phillip Karpowicz; Tomoyuki Inoue; Susan B Runciman; Brian Deveale; Raewyn M Seaberg; Marina Gertsenstein; Lois Byers; Yojiro Yamanaka; Sandra Tondat; John C Slevin; Seiji Hitoshi; Janet Rossant; Derek van der Kooy
Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(20):5437-47.
2007: Shunbin Xu; Mary E Sunderland; Brenda L K Coles; Angela Kam; Tamara Holowacz; Ruth Ashery-Padan; Till Marquardt; Roderick R McInnes; Derek van der Kooy
The proliferation and expansion of retinal stem cells require functional Pax6.
Developmental biology 2007;304(2):713-21.
2007: Matthew Fagnani; Yoseph Barash; Joanna Y Ip; Christine M Misquitta; Qun Pan; Arneet L Saltzman; Ofer Shai; Leo Lee; Aviad Rozenhek; Naveed Mohammad; Sandrine Willaime-Morawek; Tomas Babak; Wen Zhang; Timothy R Hughes; Derek van der Kooy; Brendan J Frey; Benjamin J Blencowe
Functional coordination of alternative splicing in the mammalian central nervous system.
Genome biology 2007;8(6):R108.
2006: Claudia M C Batista; Tod E Kippin; Sandrine Willaime-Morawek; Marília Kimie Shimabukuro; Wado Akamatsu; Derek van der Kooy
A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(41):10452-60.
2006: Sandrine Willaime-Morawek; Raewyn M Seaberg; Claudia Batista; Etienne Labbé; Liliana Attisano; Jessica A Gorski; Kevin R Jones; Angela Kam; Cindi M Morshead; Derek van der Kooy
Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells.
The Journal of cell biology 2006;175(1):159-68.
2006: Tamaki Wada; Jody J Haigh; Masatsugu Ema; Seiji Hitoshi; Radha Chaddah; Janet Rossant; Andras Nagy; Derek van der Kooy
Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(25):6803-12.
2006: Simon R Smukler; Susan B Runciman; Shunbin Xu; Derek van der Kooy
Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences.
The Journal of cell biology 2006;172(1):79-90.
2006: Tania O Alexson; Seiji Hitoshi; Brenda L Coles; alan bernstein; Derek van der Kooy
Notch signaling is required to maintain all neural stem cell populations--irrespective of spatial or temporal niche.
Developmental neuroscience 2006;28(1-2):34-48.
2006: Brenda L K Coles; D Jonathan Horsford; Roderick R McInnes; Derek van der Kooy
Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo.
The European journal of neuroscience 2006;23(1):75-82.
2005: Phillip Karpowicz; Cindi M Morshead; Angela Kam; Eric Jervis; John Ramunas; John Ramuns; Vincent Cheng; Derek van der Kooy
Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro.
The Journal of cell biology 2005;170(5):721-32.
2005: Tod E Kippin; Shitij Kapur; Derek van der Kooy
Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(24):5815-23.
2005: Phillip Karpowicz; Cynthia B Cohen; Derek van der Kooy
Developing human-nonhuman chimeras in human stem cell research: ethical issues and boundaries.
Kennedy Institute of Ethics journal 2005;15(2):107-34.
2005: Tod E Kippin; David J Martens; Derek van der Kooy
p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity.
Genes & development 2005;19(6):756-67.
2005: Raewyn M Seaberg; Simon R Smukler; Derek van der Kooy
Intrinsic differences distinguish transiently neurogenic progenitors from neural stem cells in the early postnatal brain.
Developmental biology 2005;278(1):71-85.
2004: Karen Atkinson-Leadbeater; William M Nuttley; Derek van der Kooy
A genetic dissociation of learning and recall in Caenorhabditis elegans.
Behavioral neuroscience 2004;118(6):1206-13.
2004: Brenda L K Coles; Brigitte Angénieux; Tomoyuki Inoue; Katia Del Rio-Tsonis; Jason R Spence; Roderick R McInnes; Yvan Arsenijevic; Derek van der Kooy
Facile isolation and the characterization of human retinal stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(44):15772-7.
2004: Steven R Laviolette; Derek van der Kooy
GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state.
The European journal of neuroscience 2004;20(8):2179-87.
2004: Raewyn M Seaberg; Simon R Smukler; Timothy J Kieffer; Grigori Enikolopov; Zeenat Asghar; Michael B Wheeler; Gregory S Korbutt; Derek van der Kooy
Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages.
Nature biotechnology 2004;22(9):1115-24.
2004: Seiji Hitoshi; Raewyn M Seaberg; Cheryl Koscik; Tania O Alexson; Susumu Kusunoki; Ichiro Kanazawa; Shoji Tsuji; Derek van der Kooy
Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling.
Genes & development 2004;18(15):1806-11.
2004: Eric Law; William M Nuttley; Derek van der Kooy
Contextual taste cues modulate olfactory learning in C. elegans by an occasion-setting mechanism.
Current biology : CB 2004;14(14):1303-8.
2004: Hai-Ying M Cheng; Steven R Laviolette; Derek van der Kooy; Josef M Penninger
DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine.
The European journal of neuroscience 2004;19(11):3033-41.
2004: Phillip Karpowicz; Cynthia B Cohen; Derek van der Kooy
It is ethical to transplant human stem cells into nonhuman embryos.
Nature medicine 2004;10(4):331-5.
2004: Cindi M Morshead; Derek van der Kooy
Disguising adult neural stem cells.
Current opinion in neurobiology 2004;14(1):125-31.
2004: Steven R Laviolette; Roger A Gallegos; Steven J Henriksen; Derek van der Kooy
Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area.
Nature neuroscience 2004;7(2):160-9.
2004: Suparna Sanyal; Richard F Wintle; Katie S Kindt; William M Nuttley; Rokhand Arvan; Paul Fitzmaurice; Eve Bigras; David C Merz; Terence E Hébert; Derek van der Kooy; William R Schafer; Joseph G Culotti; Hubert H M Van Tol
Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans.
The EMBO journal 2004;23(2):473-82.
2004: Wen Zhang; Quaid Morris; Richard Chang; Ofer Shai; Malina A Bakowski; Nicholas Mitsakakis; Naveed Mohammad; Mark D Robinson; Ralph Zirngibl; Eszter Somogyi; Nancy Laurin; Eftekhar Eftekharpour; Eric Sat; Jörg Grigull; Qun Pan; Wen-Tao Peng; Nevan J Krogan; Jack Greenblatt; Michael G Fehlings; Derek van der Kooy; Jane E Aubin; Benoit G Bruneau; Janet Rossant; Benjamin J Blencowe; Brendan J Frey; Timothy R Hughes
The functional landscape of mouse gene expression.
Journal of biology 2004;3(5):21.
2004: Steven R Laviolette; Derek van der Kooy
The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour.
Nature reviews. Neuroscience 2004;5(1):55-65.
2003: Tod E Kippin; Derek van der Kooy
Excitotoxic lesions of the tegmental pedunculopontine nucleus impair copulation in naive male rats and block the rewarding effects of copulation in experienced male rats.
The European journal of neuroscience 2003;18(9):2581-91.
2003: Cindi M Morshead; A Denise R Garcia; Michael V Sofroniew; Derek van der Kooy
The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells.
The European journal of neuroscience 2003;18(1):76-84.
2003: Raewyn M Seaberg; Derek van der Kooy
Stem and progenitor cells: the premature desertion of rigorous definitions.
Trends in neurosciences 2003;26(3):125-31.
2003: Steven R Laviolette; Derek van der Kooy
The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor.
Psychopharmacology 2003;166(3):306-13.
2003: Steven R Laviolette; Derek van der Kooy
Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area.
Molecular psychiatry 2003;8(1):50-9, 9.
2002: Steven R Laviolette; Tania O Alexson; Derek van der Kooy
Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(19):8653-60.
2002: William M Nuttley; Karen Atkinson-Leadbeater; Derek van der Kooy
Serotonin mediates food-odor associative learning in the nematode Caenorhabditiselegans.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12449-54.
2002: David J Martens; Raewyn M Seaberg; Derek van der Kooy
In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord.
The European journal of neuroscience 2002;16(6):1045-57.
2002: Seiji Hitoshi; Tania O Alexson; Vincent Tropepe; Dorit B Donoviel; Andrew Elia; Jeffrey S Nye; Ronald A Conlon; Tak W Mak; alan bernstein; Derek van der Kooy
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.
Genes & development 2002;16(7):846-58.
2002: Raewyn M Seaberg; Derek van der Kooy
Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1784-93.
2002: Cindi M Morshead; Patricia Benveniste; Norman N Iscove; Derek van der Kooy
Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations.
Nature medicine 2002;8(3):268-73.
2002: Steven R Laviolette; Karim Nader; Derek van der Kooy
Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes.
Behavioural brain research 2002;129(1-2):17-29.
2002: Hai-Ying M Cheng; Graham M Pitcher; Steven R Laviolette; Ian Q Whishaw; Kit I Tong; Lisa Kockeritz; Teiji Wada; Nicholas Joza; Michael A Crackower; Jason Goncalves; Ildiko Sarosi; James R Woodgett; Antonio J Oliveira-dos-Santos; Mitsuhiko Ikura; Derek van der Kooy; Michael W Salter; Josef M Penninger
DREAM is a critical transcriptional repressor for pain modulation.
Cell 2002;108(1):31-43.
2002: Seiji Hitoshi; Vincent Tropepe; Marc Ekker; Derek van der Kooy
Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain.
Development (Cambridge, England) 2002;129(1):233-44.
2001: C L Dockstader; Derek van der Kooy
Mouse strain differences in opiate reward learning are explained by differences in anxiety, not reward or learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(22):9077-81.
2001: GE Morrison; Derek van der Kooy
A mutation in the AMPA-type glutamate receptor, glr-1, blocks olfactory associative and nonassociative learning in Caenorhabditis elegans.
Behavioral neuroscience 2001;115(3):640-9.
2001: William M Nuttley; S Harbinder; Derek van der Kooy
Regulation of distinct attractive and aversive mechanisms mediating benzaldehyde chemotaxis in Caenorhabditis elegans.
Learning & memory (Cold Spring Harbor, N.Y.) 2001;8(3):170-81.
2001: H A Clarke; D M Skinner; Derek van der Kooy
Combined hippocampal and amygdala lesions block learning of a response-independent form of occasion setting.
Behavioral neuroscience 2001;115(2):341-57.
2001: Vincent Tropepe; Seiji Hitoshi; C Sirard; Tak W Mak; Janet Rossant; Derek van der Kooy
Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism.
Neuron 2001;30(1):65-78.
2001: Steven R Laviolette; Derek van der Kooy
GABA(A) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivational systems.
The European journal of neuroscience 2001;13(5):1009-15.
2001: C L Dockstader; M Rubinstein; David K Grandy; Malcolm J Low; Derek van der Kooy
The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice.
The European journal of neuroscience 2001;13(5):995-1001.
2001: Cindi M Morshead; Derek van der Kooy
A new 'spin' on neural stem cells?
Current opinion in neurobiology 2001;11(1):59-65.
2000: N Bernhard; Derek van der Kooy
A behavioral and genetic dissection of two forms of olfactory plasticity in Caenorhabditis elegans: adaptation and habituation.
Learning & memory (Cold Spring Harbor, N.Y.) 2000;7(4):199-212.
2000: Vincent Tropepe; Brenda L K Coles; BJ Chiasson; D Jonathan Horsford; Andrew Elia; Roderick R McInnes; Derek van der Kooy
Retinal stem cells in the adult mammalian eye.
Science (New York, N.Y.) 2000;287(5460):2032-6.
2000: Derek van der Kooy; S Weiss
Why stem cells?
Science (New York, N.Y.) 2000;287(5457):1439-41.
2000: Cindi M Morshead; Derek van der Kooy
A cell-survival factor (N-acetyl-L-cysteine) alters the in vivo fate of constitutively proliferating subependymal cells in the adult forebrain.
Journal of neurobiology 2000;42(3):338-46.
2000: D J Martens; Vincent Tropepe; Derek van der Kooy
Separate proliferation kinetics of fibroblast growth factor-responsive and epidermal growth factor-responsive neural stem cells within the embryonic forebrain germinal zone.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(3):1085-95.
1999: E H Van Vulpen; Derek van der Kooy
NGF facilitates the developmental maturation of the previously committed cholinergic interneurons in the striatal matrix.
The Journal of comparative neurology 1999;411(1):87-96.
1999: BJ Chiasson; Vincent Tropepe; Cindi M Morshead; Derek van der Kooy
Adult mammalian forebrain ependymal and subependymal cells demonstrate proliferative potential, but only subependymal cells have neural stem cell characteristics.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(11):4462-71.
1999: GE Morrison; J Y Wen; Susan B Runciman; Derek van der Kooy
Olfactory associative learning in Caenorhabditis elegans is impaired in lrn-1 and lrn-2 mutants.
Behavioral neuroscience 1999;113(2):358-67.
1999: Vincent Tropepe; Maria Sibilia; Brian Ciruna; Janet Rossant; E F Wagner; Derek van der Kooy
Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon.
Developmental biology 1999;208(1):166-88.
1999: CG Craig; R D'sa; Cindi M Morshead; A Roach; Derek van der Kooy
Migrational analysis of the constitutively proliferating subependyma population in adult mouse forebrain.
Neuroscience 1999;93(3):1197-206.
1998: E H van Vulpen; Derek van der Kooy
Striatal cholinergic interneurons: birthdates predict compartmental localization.
Brain research. Developmental brain research 1998;109(1):51-8.
1998: Cindi M Morshead; CG Craig; Derek van der Kooy
In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain.
Development (Cambridge, England) 1998;125(12):2251-61.
1998: Antoine Bechara; Karim Nader; Derek van der Kooy
A two-separate-motivational-systems hypothesis of opioid addiction.
Pharmacology, biochemistry, and behavior 1998;59(1):1-17.
1997: Vincent Tropepe; CG Craig; Cindi M Morshead; Derek van der Kooy
Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7850-9.
1997: GE Morrison; Derek van der Kooy
Cold shock before associative conditioning blocks memory retrieval, but cold shock after conditioning blocks memory retention in Caenorhabditis elegans.
Behavioral neuroscience 1997;111(3):564-78.
1997: J Y Wen; N Kumar; G Morrison; G Rambaldini; Susan B Runciman; J Rousseau; Derek van der Kooy
Mutations that prevent associative learning in C. elegans.
Behavioral neuroscience 1997;111(2):354-68.
1997: Karim Nader; A Bechara; Derek van der Kooy
Neurobiological constraints on behavioral models of motivation.
Annual review of psychology 1997;48():85-114.
1997: Karim Nader; Derek van der Kooy
Deprivation state switches the neurobiological substrates mediating opiate reward in the ventral tegmental area.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(1):383-90.
1996: Karim Nader; Antoine Bechara; Derek van der Kooy
Lesions of the lateral parabrachial nucleus block the aversive motivational effects of both morphine and morphine withdrawal but spare morphine's discriminative properties.
Behavioral neuroscience 1996;110(6):1496-502.
1996: Derek van der Kooy
Early postnatal lesions of the substantia nigra produce massive shrinkage of the rat striatum, disruption of patch neuron distribution, but no loss of patch neurons.
Brain research. Developmental brain research 1996;94(2):242-5.
1996: C G Craig; Vincent Tropepe; Cindi M Morshead; Brent Reynolds; S Weiss; Derek van der Kooy
In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(8):2649-58.
1996: Karim Nader; Derek van der Kooy
Clonidine antagonizes the aversive effects of opiate withdrawal and the rewarding effects of morphine only in opiate withdrawn rats.
Behavioral neuroscience 1996;110(2):389-400.
1996: E H Van Vulpen; Derek van der Kooy
Differential maturation of cholinergic interneurons in the striatal patch versus matrix compartments.
The Journal of comparative neurology 1996;365(4):683-91.
1996: T V Jaeger; Derek van der Kooy
Separate neural substrates mediate the motivating and discriminative properties of morphine.
Behavioral neuroscience 1996;110(1):181-201.
1995: K Reznikov; Derek van der Kooy
Variability and partial synchrony of the cell cycle in the germinal zone of the early embryonic cerebral cortex.
The Journal of comparative neurology 1995;360(3):536-54.
1995: M Goldsmith; L Yarbrough; Derek van der Kooy
Mechanics of motility: distinct dynein binding domains on alpha- and beta-tubulin.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(9-10):665-71.
1995: J L Parker; Derek van der Kooy
Tegmental pedunculopontine nucleus lesions do not block cocaine reward.
Pharmacology, biochemistry, and behavior 1995;52(1):77-83.
1995: R M Hoffarth; J G Johnston; L A Krushel; Derek van der Kooy
The mouse mutation reeler causes increased adhesion within a subpopulation of early postmitotic cortical neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(7 Pt 1):4838-50.
1995: L A Krushel; Gord Fishell; Derek van der Kooy
Pattern formation in the mammalian forebrain: striatal patch and matrix neurons intermix prior to compartment formation.
The European journal of neuroscience 1995;7(6):1210-9.
1995: Antoine Bechara; Karim Nader; Derek van der Kooy
Neurobiology of withdrawal motivation: evidence for two separate aversive effects produced in morphine-naive versus morphine-dependent rats by both naloxone and spontaneous withdrawal.
Behavioral neuroscience 1995;109(1):91-105.
1994: Karim Nader; Antoine Bechara; David Roberts; Derek van der Kooy
Neuroleptics block high- but not low-dose heroin place preferences: further evidence for a two-system model of motivation.
Behavioral neuroscience 1994;108(6):1128-38.
1994: Cindi M Morshead; Brent Reynolds; C G Craig; M W McBurney; W A Staines; Dante J Morassutti; S Weiss; Derek van der Kooy
Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells.
Neuron 1994;13(5):1071-82.
1994: T L Stefurak; Derek van der Kooy
Tegmental pedunculopontine lesions in rats decrease saccharin's rewarding effects but not its memory-improving effect.
Behavioral neuroscience 1994;108(5):972-80.
1994: D M Skinner; Gerard M Martin; C Harley; B Kolb; A Pridgar; Antoine Bechara; Derek van der Kooy
Acquisition of conditional discriminations in hippocampal lesioned and decorticated rats: evidence for learning that is separate from both simple classical conditioning and configural learning.
Behavioral neuroscience 1994;108(5):911-26.
1994: J Y Wen; Cindi M Morshead; Derek van der Kooy
Satellite cell proliferation in the adult rat trigeminal ganglion results from the release of a mitogenic protein from explanted sensory neurons.
The Journal of cell biology 1994;124(6):1005-15.
1993: L A Krushel; Derek van der Kooy
Pattern formation in the developing mammalian forebrain: selective adhesion of early but not late postmitotic cortical and striatal neurons within forebrain reaggregate cultures.
Developmental biology 1993;158(1):145-62.
1993: S E Acklin; Derek van der Kooy
Clonal heterogeneity in the germinal zone of the developing rat telencephalon.
Development (Cambridge, England) 1993;118(1):175-92.
1993: L A Krushel; J G Johnston; Gord Fishell; R Tibshirani; Derek van der Kooy
Spatially localized neuronal cell lineages in the developing mammalian forebrain.
Neuroscience 1993;53(4):1035-47.
1993: Antoine Bechara; Gerard M Martin; A Pridgar; Derek van der Kooy
The parabrachial nucleus: a brain stem substrate critical for mediating the aversive motivational effects of morphine.
Behavioral neuroscience 1993;107(1):147-60.
1993: T V Jaeger; Derek van der Kooy
Morphine acts in the parabrachial nucleus, a pontine viscerosensory relay, to produce discriminative stimulus effects.
Psychopharmacology 1993;110(1-2):76-84.
1992: Antoine Bechara; F Harrington; Karim Nader; Derek van der Kooy
Neurobiology of motivation: double dissociation of two motivational mechanisms mediating opiate reward in drug-naive versus drug-dependent animals.
Behavioral neuroscience 1992;106(5):798-807.
1992: M Goldsmith; S Leyland; J A Connolly; Derek van der Kooy
A unique tubulin antiserum attenuates the rate of poleward chromosome movement in anaphase.
European journal of cell biology 1992;58(2):346-55.
1992: Antoine Bechara; Derek van der Kooy
Lesions of the tegmental pedunculopontine nucleus: effects on the locomotor activity induced by morphine and amphetamine.
Pharmacology, biochemistry, and behavior 1992;42(1):9-18.
1992: K Horgan; Derek van der Kooy
Visceral targets specify calcitonin gene-related peptide and substance P enrichment in trigeminal afferent projections.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(4):1135-43.
1992: Antoine Bechara; Derek van der Kooy
Chronic exposure to morphine does not alter the neural tissues subserving its acute rewarding properties: apparent tolerance is overshadowing.
Behavioral neuroscience 1992;106(2):364-73.
1992: Antoine Bechara; Derek van der Kooy
A single brain stem substrate mediates the motivational effects of both opiates and food in nondeprived rats but not in deprived rats.
Behavioral neuroscience 1992;106(2):351-63.
1992: Derek van der Kooy; Gord Fishell
Embryonic lesions of the substantia nigra prevent the patchy expression of opiate receptors, but not the segregation of patch and matrix compartment neurons, in the developing rat striatum.
Brain research. Developmental brain research 1992;66(1):141-5.
1992: T L Stefurak; Derek van der Kooy
Saccharin's rewarding, conditioned reinforcing, and memory-improving properties: mediation by isomorphic or independent processes?
Behavioral neuroscience 1992;106(1):125-39.
1992: Cindi M Morshead; Derek van der Kooy
Postmitotic death is the fate of constitutively proliferating cells in the subependymal layer of the adult mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(1):249-56.
1991: Gord Fishell; Derek van der Kooy
Pattern formation in the striatum: neurons with early projections to the substantia nigra survive the cell death period.
The Journal of comparative neurology 1991;312(1):33-42.
1991: T Hattori; M Takada; T Moriizumi; Derek van der Kooy
Single dopaminergic nigrostriatal neurons form two chemically distinct synaptic types: possible transmitter segregation within neurons.
The Journal of comparative neurology 1991;309(3):391-401.
1991: M Goldsmith; J A Connolly; N Kumar; J Wu; L R Yarbrough; Derek van der Kooy
Conserved beta-tubulin binding domain for the microtubule-associated motors underlying sperm motility and fast axonal transport.
Cell motility and the cytoskeleton 1991;20(3):249-62.
1990: Cindi M Morshead; Derek van der Kooy
Separate blood and brain origins of proliferating cells during gliosis in adult brains.
Brain research 1990;535(2):237-44.
1990: J G Johnston; Charles R Gerfen; S N Haber; Derek van der Kooy
Mechanisms of striatal pattern formation: conservation of mammalian compartmentalization.
Brain research. Developmental brain research 1990;57(1):93-102.
1990: Gord Fishell; Janet Rossant; Derek van der Kooy
Neuronal lineages in chimeric mouse forebrain are segregated between compartments and in the rostrocaudal and radial planes.
Developmental biology 1990;141(1):70-83.
1990: K Horgan; T P O'Connor; Derek van der Kooy
Prenatal specification and target induction underlie the enrichment of calcitonin gene-related peptide in the trigeminal ganglion neurons projecting to the cerebral vasculature.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(7):2485-92.
1990: Gerard M Martin; M Gans; Derek van der Kooy
Discriminative properties of morphine that modulate associations between tastes and lithium chloride.
Journal of experimental psychology. Animal behavior processes 1990;16(1):56-68.
1989: Antoine Bechara; Derek van der Kooy
The tegmental pedunculopontine nucleus: a brain-stem output of the limbic system critical for the conditioned place preferences produced by morphine and amphetamine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1989;9(10):3400-9.
1989: L A Krushel; J A Connolly; Derek van der Kooy
Pattern formation in the mammalian forebrain: patch neurons from the rat striatum selectively reassociate in vitro.
Brain research. Developmental brain research 1989;47(1):137-42.
1989: T P O'Connor; Derek van der Kooy
Cooperation and competition during development: neonatal lesioning of the superior cervical ganglion induces cell death of trigeminal neurons innervating the cerebral blood vessels but prevents the loss of axon collaterals from the neurons that survive.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1989;9(5):1490-501.
1989: Gord Fishell; Derek van der Kooy
Pattern formation in the striatum: developmental changes in the distribution of striatonigral projections.
Brain research. Developmental brain research 1989;45(2):239-55.
1989: J G Johnston; Derek van der Kooy
Protooncogene expression identifies a transient columnar organization of the forebrain within the late embryonic ventricular zone.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):1066-70.
1988: K A Zito; Antoine Bechara; C Greenwood; Derek van der Kooy
The dopamine innervation of the visceral cortex mediates the aversive effects of opiates.
Pharmacology, biochemistry, and behavior 1988;30(3):693-9.
1988: Gerard M Martin; Antoine Bechara; Derek van der Kooy
Morphine preexposure attenuates the aversive properties of opiates without preexposure to the aversive properties.
Pharmacology, biochemistry, and behavior 1988;30(3):687-92.
1988: T P O'Connor; Derek van der Kooy
Enrichment of a vasoactive neuropeptide (calcitonin gene related peptide) in the trigeminal sensory projection to the intracranial arteries.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(7):2468-76.
1988: M Goldsmith; Derek van der Kooy
Separate non-cholinergic descending projections and cholinergic ascending projections from the nucleus tegmenti pedunculopontinus.
Brain research 1988;445(2):386-91.
1988: L A Krushel; Derek van der Kooy
Visceral cortex: integration of the mucosal senses with limbic information in the rat agranular insular cortex.
The Journal of comparative neurology 1988;270(1):39-54, 62-3.
1987: M Takada; Gord Fishell; Z K Li; Derek van der Kooy; T Hattori
The development of laterality in the forebrain projections of midline thalamic cell groups in the rat.
Brain research 1987;432(2):275-82.
1987: Antoine Bechara; Derek van der Kooy
Kappa receptors mediate the peripheral aversive effects of opiates.
Pharmacology, biochemistry, and behavior 1987;28(2):227-33.
1987: Antoine Bechara; K A Zito; Derek van der Kooy
Peripheral receptors mediate the aversive conditioning effects of morphine in the rat.
Pharmacology, biochemistry, and behavior 1987;28(2):219-25.