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Aart Jan Van der Lely

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W van Dorp; Jenny A Visser; Aart Jan Van der Lely; K Blijdorp; Joop S E Laven; Sebastian J C M M Neggers; R Pieters; Marry M van den Heuvel-Eibrink
Decreased ovarian function is associated with obesity in very long-term female survivors of childhood cancer.
Karin Blijdorp; Rob Pieters; Marry van den Heuvel-Eibrink; Aart Jan Van der Lely; Marjolein van Waas; Sebastian Neggers
Endocrine sequelae and metabolic syndrome in adult long-term survivors of childhood acute myeloid leukemia.
Patric J D Delhanty; Aldo Grefhorst; Martin Huisman; Pieter J M Leenen; Axel P N Themmen; Iris van den Berge; Thierry Abribat; Lucy Y Baldeon-Rojas; Aart Jan Van der Lely
Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasis.

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2013: W van Dorp; Jenny A Visser; Aart Jan Van der Lely; K Blijdorp; Joop S E Laven; Sebastian J C M M Neggers; R Pieters; Marry M van den Heuvel-Eibrink
Decreased ovarian function is associated with obesity in very long-term female survivors of childhood cancer.
European journal of endocrinology / European Federation of Endocrine Societies 2013;168(6):905-12.
2013: Karin Blijdorp; Rob Pieters; Marry van den Heuvel-Eibrink; Aart Jan Van der Lely; Marjolein van Waas; Sebastian Neggers
Endocrine sequelae and metabolic syndrome in adult long-term survivors of childhood acute myeloid leukemia.
Leukemia research 2013;37(4):367-71.
2013: Patric J D Delhanty; Aldo Grefhorst; Martin Huisman; Pieter J M Leenen; Axel P N Themmen; Iris van den Berge; Thierry Abribat; Lucy Y Baldeon-Rojas; Aart Jan Van der Lely
Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(4):1690-700.
2013: Richard A Feelders; Sebastian J C M M Neggers; Aart Jan Van der Lely; Wouter W de Herder; Leo Hofland
Pasireotide, a multi-somatostatin receptor ligand with potential efficacy for treatment of pituitary and neuroendocrine tumors.
Drugs of today (Barcelona, Spain : 1998) 2013;49(2):89-103.
2013: Patric J D Delhanty; Sebastian J C M M Neggers; Aart Jan Van der Lely
Des-acyl ghrelin: a metabolically active Peptide.
Endocrine development 2013;25():112-21.
2012: Patric J D Delhanty; Sebastian J C M M Neggers; Aart Jan Van der Lely
Mechanisms in endocrinology: Ghrelin: the differences between acyl- and des-acyl ghrelin.
European journal of endocrinology / European Federation of Endocrine Societies 2012;167(5):601-8.
2012: Martijn van der Velde; Julia M M Almering; Patric J D Delhanty; Roy G Smith; Yuxiang Sun; B C J van der Eerden; Aart Jan Van der Lely; Johannes P T M van Leeuwen
An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects.
Endocrinology 2012;153(8):3593-602.
2012: Marjolein van Waas; Aart Jan Van der Lely; Judith P van Eck; Max M van Noesel; Frank H de Jong; Sebastian J C M M Neggers; Rob Pieters; Marry M van den Heuvel-Eibrink
Adrenal function in adult long-term survivors of nephroblastoma and neuroblastoma.
European journal of cancer (Oxford, England : 1990) 2012;48(8):1159-66.
2012: Andrea Benso; Ezio Ghigo; Enrico Gramaglia; Riccarda Granata; Flavia Prodam; D H St-Pierre; Aart Jan Van der Lely; Fabio Broglio
Metabolic effects of overnight continuous infusion of unacylated ghrelin in humans.
European journal of endocrinology / European Federation of Endocrine Societies 2012;166(5):911-6.
2012: Valentina Gasco; Ezio Ghigo; G Beccuti; J Janssen; Mauro Maccario; F Marotta; N Prencipe; Aart Jan Van der Lely; Silvia Grottoli
Effects of chronic slow release-lanreotide treatment on insulin-like growth factor system and metabolic parameters in acromegalic patients.
Journal of endocrinological investigation 2012;35(4):372-7.
2012: Riccarda Granata; Michel Julien; Rita Nano; Lorenzo Piemonti; Fabio Settanni; Gabriele Togliatto; Antonella Trombetta; Aart Jan Van der Lely; Thierry Abribat; Maria Felice Brizzi; Davide Gallo; Ezio Ghigo
Des-acyl ghrelin fragments and analogues promote survival of pancreatic β-cells and human pancreatic islets and prevent diabetes in streptozotocin-treated rats.
Journal of medicinal chemistry 2012;55(6):2585-96.
2012: Karin Blijdorp; Annemieke M Boot; Patric J D Delhanty; Rob Pieters; Marry M van den Heuvel-Eibrink; Aart Jan Van der Lely; Sebastian J C M M Neggers
Obesity is underestimated using body mass index and waist-hip ratio in long-term adult survivors of childhood cancer.
PloS one 2012;7(8):e43269.
2011: R A Alwani; Wouter W de Herder; Frank de Jong; S W J Lamberts; Aart Jan Van der Lely; Richard A Feelders
Rapid decrease in adrenal responsiveness to ACTH stimulation after successful pituitary surgery in patients with Cushing's disease.
Clinical endocrinology 2011;75(5):602-7.
2011: Rosalie M Kiewiet; Axel P N Themmen; Maarten O van Aken; K van der Weerd; Jenny A Visser; M J Hazell; Aart Jan Van der Lely
Acute effects of acylated and unacylated ghrelin on total and high molecular weight adiponectin inmorbidly obese subjects.
Journal of endocrinological investigation 2011;34(6):434-8.
2011: Aart Jan Van der Lely; Ignacio Bernabeu; Jan Cap; Philippe Caron; Annamaria Colao; Josef Marek; Sebastian Neggers; Pascal Birman
Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone.
European journal of endocrinology / European Federation of Endocrine Societies 2011;164(3):325-33.
2011: Sebastian J C M M Neggers; Aart Jan Van der Lely
Modulation of glucocorticoid metabolism by the GH-IGF-I axis.
Endocrine development 2011;20():181-6.
2011: Sebastian J Neggers; John J Kopchick; Jens O L Jørgensen; Aart Jan Van der Lely
Hypothesis: Extra-hepatic acromegaly: a new paradigm?
European journal of endocrinology / European Federation of Endocrine Societies 2011;164(1):11-6.
2010: Patric J D Delhanty; Anke van Kerkwijk; Martin Huisman; Bedette van de Zande; Miriam Verhoef-Post; Carlotta Gauna; Leo Hofland; Axel P N Themmen; Aart Jan Van der Lely
Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization.
American journal of physiology. Endocrinology and metabolism 2010;299(3):E497-505.
2010: Riccarda Granata; Marco Volante; Fabio Settanni; Carlotta Gauna; Corrado Ghé; Marta Annunziata; Barbara Deidda; Iacopo Gesmundo; Thierry Abribat; Aart Jan Van der Lely; Giampiero Muccioli; Ezio Ghigo; Mauro Papotti
Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats.
Journal of molecular endocrinology 2010;45(1):9-17.
2010: Richard A Feelders; Christiaan de Bruin; Alberto M Pereira; Johannes A Romijn; Romana T Netea-Maier; Ad R Hermus; Pierre M Zelissen; Ramona van Heerebeek; Frank de Jong; Aart Jan Van der Lely; Wouter W de Herder; Leo J Hofland; Steven W Lamberts
Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease.
The New England journal of medicine 2010;362(19):1846-8.
2010: Patric J D Delhanty; Yuxiang Sun; Jenny A Visser; Anke van Kerkwijk; Martin Huisman; Wilfred F J van Ijcken; SM Swagemakers; Roy G Smith; Axel P N Themmen; Aart Jan Van der Lely
Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice.
PloS one 2010;5(7):e11749.
2010: R A Alwani; Wouter W de Herder; Maarten O van Aken; J H van den Berge; EJ Delwel; A H G Dallenga; Frank de Jong; S W J Lamberts; Aart Jan Van der Lely; Richard A Feelders
Biochemical predictors of outcome of pituitary surgery for Cushing's disease.
Neuroendocrinology 2010;91(2):169-78.
2009: Richard A Feelders; Leo J Hofland; Maarten O van Aken; Sebastian J Neggers; Steven W J Lamberts; Wouter W de Herder; Aart Jan Van der Lely
Medical therapy of acromegaly: efficacy and safety of somatostatin analogues.
Drugs 2009;69(16):2207-26.
2009: Sebastian J C Neggers; Aart Jan Van der Lely
Somatostatin analog and pegvisomant combination therapy for acromegaly.
Nature reviews. Endocrinology 2009;5(10):546-52.
2009: Rosalie M Kiewiet; Maarten O van Aken; Kim van der Weerd; Piet Uitterlinden; Axel P N Themmen; Leo J Hofland; Yolanda B De Rijke; Patric J D Delhanty; Ezio Ghigo; Thierry Abribat; Aart Jan Van der Lely
Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2009;161(4):567-73.
2009: Greisa Vila; Michaela Riedl; Michael Resl; Aart Jan Van der Lely; Leo J Hofland; Martin Clodi; Anton Luger
Systemic administration of oxytocin reduces basal and lipopolysaccharide-induced ghrelin levels in healthy men.
The Journal of endocrinology 2009;203(1):175-9.
2009: M van Hoek; Leo J Hofland; Yolanda B De Rijke; Francien H van Nederveen; Ronald R de Krijger; Peter M Van Koetsveld; S W J Lamberts; Aart Jan Van der Lely; Wouter W de Herder; Richard A Feelders
Effects of somatostatin analogs on a growth hormone-releasing hormone secreting bronchial carcinoid, in vivo and in vitro studies.
The Journal of clinical endocrinology and metabolism 2009;94(2):428-33.
2009: Aart Jan Van der Lely
Ghrelin and new metabolic frontiers.
Hormone research 2009;71 Suppl 1():129-33.
2008: Rosalie M Kiewiet; Carlotta Gauna; Maarten O van Aken; Bedette van de Zande; Aart Jan Van der Lely
Bolus administration of obestatin does not change glucose and insulin levels neither in the systemic nor in the portal circulation of the rat.
Peptides 2008;29(12):2144-9.
2008: S J C M M Neggers; Maarten O van Aken; Wouter W de Herder; Richard A Feelders; Joop A M J L Janssen; X Badia; S M Webb; Aart Jan Van der Lely
Quality of life in acromegalic patients during long-term somatostatin analog treatment with and without pegvisomant.
The Journal of clinical endocrinology and metabolism 2008;93(10):3853-9.
2008: Fabio Broglio; Flavia Prodam; Fabrizio Riganti; Cristina Gottero; Silvia Destefanis; Riccarda Granata; Giampiero Muccioli; T Abribat; Aart Jan Van der Lely; Ezio Ghigo
The continuous infusion of acylated ghrelin enhances growth hormone secretion and worsens glucose metabolism in humans.
Journal of endocrinological investigation 2008;31(9):788-94.
2008: Flavia Prodam; Andrea Benso; Enrico Gramaglia; Barbara Lucatello; Fabrizio Riganti; Aart Jan Van der Lely; R Deghenghi; Giampiero Muccioli; Ezio Ghigo; Fabio Broglio
Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans.
Neuropeptides 2008;42(1):89-93.
2008: Martijn van der Velde; Patric J D Delhanty; B C J van der Eerden; Aart Jan Van der Lely; Johannes van Leeuwen
Ghrelin and bone.
Vitamins and hormones 2008;77():239-58.
2007: Sebastian J C M M Neggers; Maarten O van Aken; Joop A M J L Janssen; Richard A Feelders; Wouter W de Herder; Aart Jan Van der Lely
Long-term efficacy and safety of combined treatment of somatostatin analogs and pegvisomant in acromegaly.
The Journal of clinical endocrinology and metabolism 2007;92(12):4598-601.
2007: Carlotta Gauna; Piet Uitterlinden; Piet Kramer; Rosalie M Kiewiet; Joop A M J L Janssen; Patric J D Delhanty; Maarten O van Aken; Ezio Ghigo; Leo J Hofland; Axel P N Themmen; Aart Jan Van der Lely
Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats.
Endocrinology 2007;148(11):5278-87.
2007: Carlotta Gauna; Rosalie M Kiewiet; Joop A M J L Janssen; Bedette van de Zande; Patric J D Delhanty; Ezio Ghigo; Leo J Hofland; Axel P N Themmen; Aart Jan Van der Lely
Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions.
American journal of physiology. Endocrinology and metabolism 2007;293(3):E697-704.
2007: Carlotta Gauna; Bedette van de Zande; Anke van Kerkwijk; Axel P N Themmen; Aart Jan Van der Lely; Patric J D Delhanty
Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R).
Molecular and cellular endocrinology 2007;274(1-2):30-4.
2007: Aart Jan Van der Lely
G-forces in endocrinology.
Nature clinical practice. Endocrinology & metabolism 2007;3(8):553.
2007: Aart Jan Van der Lely
The medical treatment of acromegaly.
Endokrynologia Polska 2007;58(4):361-3.
2007: Patric J D Delhanty; Peter M Van Koetsveld; Carlotta Gauna; Bedette van de Zande; Giovanni Vitale; Leo J Hofland; Aart Jan Van der Lely
Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway.
American journal of physiology. Endocrinology and metabolism 2007;293(1):E302-9.
2007: Wouter W de Herder; Ambroos E M Reijs; Richard A Feelders; Maarten O van Aken; Eric P Krenning; Aart Jan Van der Lely; Dik J Kwekkeboom
Diagnostic imaging of dopamine receptors in pituitary adenomas.
European journal of endocrinology / European Federation of Endocrine Societies 2007;156 Suppl 1():S53-6.
2007: Andrea Benso; Flavia Prodam; Barbara Lucatello; Enrico Gramaglia; Fabrizio Riganti; H Schneider; Aart Jan Van der Lely; Giampiero Muccioli; Ezio Ghigo; Fabio Broglio
d-Lys-GHRP-6 does not modify the endocrine response to acylated ghrelin or hexarelin in humans.
Neuropeptides 2007;41(1):45-9.
2006: Wouter W de Herder; Ambroos E M Reijs; Richard A Feelders; Maarten O van Aken; Eric P Krenning; Hervé L J Tanghe; Aart Jan Van der Lely; Dik J Kwekkeboom
Dopamine agonist therapy of clinically non-functioning pituitary macroadenomas. Is there a role for 123I-epidepride dopamine D2 receptor imaging?
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(5):717-23.
2006: Peter M Van Koetsveld; Giovanni Vitale; Wouter W de Herder; Richard A Feelders; Katy van der Wansem; Marlijn Waaijers; C H J van Eijck; Ernst J M Speel; Ed Croze; Aart Jan Van der Lely; Steven W J Lamberts; Leo J Hofland
Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth.
The Journal of clinical endocrinology and metabolism 2006;91(11):4537-43.
2006: Flavia Prodam; Elisa Me; Fabrizio Riganti; Enrico Gramaglia; Simonetta Bellone; Roberto Baldelli; Anna Rapa; Aart Jan Van der Lely; Gianni Bona; Ezio Ghigo; Fabio Broglio
The nutritional control of ghrelin secretion in humans: the effects of enteral vs. parenteral nutrition.
European journal of nutrition 2006;45(7):399-405.
2006: S F M Bhatti; Leo J Hofland; Peter M Van Koetsveld; L M L Van Ham; Luc Duchateau; Jan A Mol; Aart Jan Van der Lely; Hans S Kooistra
Effects of food intake and food withholding on plasma ghrelin concentrations in healthy dogs.
American journal of veterinary research 2006;67(9):1557-63.
2006: Carlotta Gauna; Patric J D Delhanty; Maarten O van Aken; Joop A M J L Janssen; Axel P N Themmen; Leo J Hofland; Michael Culler; Fabio Broglio; Ezio Ghigo; Aart Jan Van der Lely
Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor.
Molecular and cellular endocrinology 2006;251(1-2):103-11.
2006: Johannes Feenstra; Maarten O van Aken; Wouter W de Herder; Richard A Feelders; Aart Jan Van der Lely
Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.
European journal of endocrinology / European Federation of Endocrine Societies 2006;154(6):805-6.
2006: Aart Jan Van der Lely
Sweet dreams and gut feelings: endocrinology makes new connections.
Nature clinical practice. Endocrinology & metabolism 2006;2(5):239.
2006: Aart Jan Van der Lely; John J Kopchick
Growth hormone receptor antagonists.
Neuroendocrinology 2006;83(3-4):264-8.
2006: Wouter W de Herder; Dik J Kwekkeboom; Richard A Feelders; Maarten O van Aken; Steven W J Lamberts; Aart Jan Van der Lely; Eric P Krenning
Somatostatin receptor imaging for neuroendocrine tumors.
Pituitary 2006;9(3):243-8.
2006: Patric J D Delhanty; B C J van der Eerden; M van der Velde; Carlotta Gauna; Huibert A P Pols; Holger Jahr; H Chiba; Aart Jan Van der Lely; Johannes P T M van Leeuwen
Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a.
The Journal of endocrinology 2006;188(1):37-47.
2005: Richard A Feelders; Martin Bidlingmaier; Christian J Strasburger; Joop A M J L Janssen; Piet Uitterlinden; Leo J Hofland; Steven W J Lamberts; Aart Jan Van der Lely; Wouter W de Herder
Postoperative evaluation of patients with acromegaly: clinical significance and timing of oral glucose tolerance testing and measurement of (free) insulin-like growth factor I, acid-labile subunit, and growth hormone-binding protein levels.
The Journal of clinical endocrinology and metabolism 2005;90(12):6480-9.
2005: Aart Jan Van der Lely; Wouter W de Herder
Carcinoid syndrome: diagnosis and medical management.
Arquivos brasileiros de endocrinologia e metabologia 2005;49(5):850-60.
2005: Ariel L Barkan; Pia Burman; David R Clemmons; William M Drake; Robert Gagel; Philip E Harris; Peter J Trainer; Aart Jan Van der Lely; Mary Lee Vance
Glucose homeostasis and safety in patients with acromegaly converted from long-acting octreotide to pegvisomant.
The Journal of clinical endocrinology and metabolism 2005;90(10):5684-91.
2005: Pamela U Freda; Laurence Katznelson; Aart Jan Van der Lely; Carlos M Reyes; Shouhao Zhao; daniel rabinowitz
Long-acting somatostatin analog therapy of acromegaly: a meta-analysis.
The Journal of clinical endocrinology and metabolism 2005;90(8):4465-73.
2005: Wouter W de Herder; H Rob Taal; Piet Uitterlinden; Richard A Feelders; Joop A M J L Janssen; Aart Jan Van der Lely
Limited predictive value of an acute test with subcutaneous octreotide for long-term IGF-I normalization with Sandostatin LAR in acromegaly.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(1):67-71.
2005: Johannes Feenstra; Wouter W de Herder; Saskia M T H ten Have; Annewieke W van den Beld; Richard A Feelders; Joop A M J L Janssen; Aart Jan Van der Lely
Combined therapy with somatostatin analogues and weekly pegvisomant in active acromegaly.
Lancet 2005;365(9471):1644-6.
2005: Ingrid E Bonapart; Ron T van Domburg; Saskia M T H ten Have; Wouter W de Herder; Ruud A M Erdman; Joop A M J L Janssen; Aart Jan Van der Lely
The 'bio-assay' quality of life might be a better marker of disease activity in acromegalic patients than serum total IGF-I concentrations.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(2):217-24.
2005: Carlotta Gauna; Patric J D Delhanty; Leo J Hofland; Joop A M J L Janssen; Fabio Broglio; Richard J M Ross; Ezio Ghigo; Aart Jan Van der Lely
Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes.
The Journal of clinical endocrinology and metabolism 2005;90(2):1055-60.
2005: Wouter W de Herder; Dik J Kwekkeboom; R Valkema; Richard A Feelders; Maarten O van Aken; Steven W J Lamberts; Aart Jan Van der Lely; E P Krenning
Neuroendocrine tumors and somatostatin: imaging techniques.
Journal of endocrinological investigation 2005;28(11 Suppl International):132-6.
2005: Carlotta Gauna; Aart Jan Van der Lely
Somatostatin, cortistatin, ghrelin and glucose metabolism.
Journal of endocrinological investigation 2005;28(11 Suppl International):127-31.
2005: Leo J Hofland; Joost van der Hoek; Richard A Feelders; Aart Jan Van der Lely; Wouter W de Herder; Steven W J Lamberts
Pre-clinical and clinical experiences with novel somatostatin ligands: advantages, disadvantages and new prospects.
Journal of endocrinological investigation 2005;28(11 Suppl International):36-42.
2005: Carlotta Gauna; Greet Van den Berghe; Aart Jan Van der Lely
Pituitary function during severe and life-threatening illnesses.
Pituitary 2005;8(3-4):213-7.
2005: Menno T Zomerhuis; Shahid M Hussain; Richard A Feelders; Aart Jan Van der Lely; Wouter W de Herder
Octreotide exerts only acute, but no sustained, effects on MRI enhancement of liver metastases in carcinoid syndrome.
Neuroendocrinology 2005;82(1):41-8.
2004: Cristina Gottero; Fabio Broglio; Flavia Prodam; Silvia Destefanis; Simonetta Bellone; Andrea Benso; Carlotta Gauna; Emanuela Arvat; Aart Jan Van der Lely; Ezio Ghigo
Ghrelin: a link between eating disorders, obesity and reproduction.
Nutritional neuroscience 2004;7(5-6):255-70.
2004: Alex F Muller; Aart Jan Van der Lely
Insights from growth hormone receptor blockade.
Current opinion in investigational drugs (London, England : 2000) 2004;5(10):1072-9.
2004: Fabio Broglio; Cristina Gottero; Flavia Prodam; Silvia Destefanis; Carlotta Gauna; Elisa Me; Fabrizio Riganti; Daniela Vivenza; Anna Rapa; Valentino Martina; Emanuela Arvat; Gianni Bona; Aart Jan Van der Lely; Ezio Ghigo
Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans.
Clinical endocrinology 2004;61(4):503-9.
2004: Carlotta Gauna; F M Meyler; Joop A M J L Janssen; Patric J D Delhanty; T Abribat; Peter M Van Koetsveld; Leo J Hofland; Fabio Broglio; Ezio Ghigo; Aart Jan Van der Lely
Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.
The Journal of clinical endocrinology and metabolism 2004;89(10):5035-42.
2004: Cristina Gottero; Flavia Prodam; Silvia Destefanis; Andrea Benso; Carlotta Gauna; Elisa Me; L Filtri; Fabrizio Riganti; Aart Jan Van der Lely; Ezio Ghigo; Fabio Broglio
Cortistatin-17 and -14 exert the same endocrine activities as somatostatin in humans.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2004;14(5):382-7.
2004: Joop A M J L Janssen; Willy Visser; Aart Jan Van der Lely
[Still no indications that the treatment of growth hormone deficient adults with growth hormones is unsafe].
Nederlands tijdschrift voor geneeskunde 2004;148(30):1486-9.
2004: Joop A M J L Janssen; D Poldermans; Leo J Hofland; Eleni C Vourvouri; Alex F Muller; J J Bax; R Deghenghi; Fabio Broglio; Ezio Ghigo; Aart Jan Van der Lely
There are no acute cardiac effects of a single iv dose of human ghrelin in severe growth hormone deficient patients.
Journal of endocrinological investigation 2004;27(7):659-64.
2004: Fabio Broglio; Cristina Gottero; Flavia Prodam; Carlotta Gauna; Giampiero Muccioli; M Papotti; T Abribat; Aart Jan Van der Lely; Ezio Ghigo
Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.
The Journal of clinical endocrinology and metabolism 2004;89(6):3062-5.
2004: Aart Jan Van der Lely; Matthias H Tschöp; Mark L Heiman; Ezio Ghigo
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.
Endocrine reviews 2004;25(3):426-57.
2004: Fabio Broglio; Flavia Prodam; Cristina Gottero; Silvia Destefanis; Elisa Me; Fabrizio Riganti; Roberta Giordano; Andreea Picu; Marcella Balbo; Aart Jan Van der Lely; Ezio Ghigo; Emanuela Arvat
Ghrelin does not mediate the somatotroph and corticotroph responses to the stimulatory effect of glucagon or insulin-induced hypoglycaemia in humans.
Clinical endocrinology 2004;60(6):699-704.
2004: Fabio Broglio; Cristina Gottero; Peter M Van Koetsveld; Flavia Prodam; Silvia Destefanis; Andrea Benso; Carlotta Gauna; Leo J Hofland; Emanuela Arvat; Aart Jan Van der Lely; Ezio Ghigo
Acetylcholine regulates ghrelin secretion in humans.
The Journal of clinical endocrinology and metabolism 2004;89(5):2429-33.
2004: Virgil A S H Dalm; P Martin van Hagen; Ronald R de Krijger; Johan M Kros; Peter M Van Koetsveld; Aart Jan Van der Lely; Steven W J Lamberts; Leo J Hofland
Distribution pattern of somatostatin and cortistatin mRNA in human central and peripheral tissues.
Clinical endocrinology 2004;60(5):625-9.
2004: Fabio Broglio; Laura Gianotti; Silvia Destefanis; Secondo Fassino; Giovanni Abbate-Daga; Valeria Mondelli; Fabio Lanfranco; Cristina Gottero; Carlotta Gauna; Leo J Hofland; Aart Jan Van der Lely; Ezio Ghigo
The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state.
Clinical endocrinology 2004;60(5):592-9.
2004: Joop A M J L Janssen; Aart Jan Van der Lely; Steven W J Lamberts
Is there a role of ghrelin in preventing catabolism?
Journal of endocrinological investigation 2004;27(4):400-3.
2004: Leo J Hofland; Joost van der Hoek; Peter M Van Koetsveld; Wouter W de Herder; Marlijn Waaijers; Diana Sprij-Mooij; Christian Bruns; Gisbert Weckbecker; Richard A Feelders; Aart Jan Van der Lely; Albert Beckers; Steven W J Lamberts
The novel somatostatin analog SOM230 is a potent inhibitor of hormone release by growth hormone- and prolactin-secreting pituitary adenomas in vitro.
The Journal of clinical endocrinology and metabolism 2004;89(4):1577-85.
2004: Alex F Muller; John J Kopchick; Allan Flyvbjerg; Aart Jan Van der Lely
Clinical review 166: Growth hormone receptor antagonists.
The Journal of clinical endocrinology and metabolism 2004;89(4):1503-11.
2004: Aart Jan Van der Lely
Growth hormone and glucose metabolism: the model of the GH-receptor antagonists.
Annales d'endocrinologie 2004;65(1):81-3.
2004: Joost van der Hoek; Wouter W de Herder; Richard A Feelders; Aart Jan Van der Lely; Piet Uitterlinden; Viktor Boerlin; Christian Bruns; Kwai W Poon; Ian Lewis; Gisbert Weckbecker; Tillmann Krahnke; Leo J Hofland; Steven W J Lamberts
A single-dose comparison of the acute effects between the new somatostatin analog SOM230 and octreotide in acromegalic patients.
The Journal of clinical endocrinology and metabolism 2004;89(2):638-45.
2004: Willem de Ronde; Saskia M T H ten Have; P L A van Daele; Richard A Feelders; Aart Jan Van der Lely
['Hungry bone' syndrome, characterized by prolonged symptomatic hypocalcemia, as a complication of the treatment for hyperthyroidism].
Nederlands tijdschrift voor geneeskunde 2004;148(5):231-4.
2004: Maarten O van Aken; Richard A Feelders; Siem de Marie; J H van de Berge; A H G Dallenga; EJ Delwel; R M L Poublon; J A Romijn; Aart Jan Van der Lely; Steven W J Lamberts; Wouter W de Herder
Cerebrospinal fluid leakage during transsphenoidal surgery: postoperative external lumbar drainage reduces the risk for meningitis.
Pituitary 2004;7(2):89-93.
2004: Alex F Muller; Aart Jan Van der Lely
Pharmacological therapy for acromegaly: a critical review.
Drugs 2004;64(16):1817-38.
2004: Virgil A S H Dalm; Leo J Hofland; Cornelia M Mooy; Marlijn Waaijers; Peter M Van Koetsveld; Anton Langerak; Frank T J Staal; Aart Jan Van der Lely; Steven W J Lamberts; Martin P van Hagen
Somatostatin receptors in malignant lymphomas: targets for radiotherapy?
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(1):8-16.
2003: Cristina Gottero; Simonetta Bellone; Anna Rapa; Peter M Van Koetsveld; Daniela Vivenza; Flavia Prodam; Andrea Benso; Silvia Destefanis; Carlotta Gauna; Jaele Bellone; Leo J Hofland; Aart Jan Van der Lely; Gianni Bona; Ezio Ghigo; Fabio Broglio
Standard light breakfast inhibits circulating ghrelin level to the same extent of oral glucose load in humans, despite different impact on glucose and insulin levels.
Journal of endocrinological investigation 2003;26(12):1203-7.
2003: Wouter W de Herder; Leo J Hofland; Aart Jan Van der Lely; Steven W J Lamberts
Somatostatin receptors in gastroentero-pancreatic neuroendocrine tumours.
Endocrine-related cancer 2003;10(4):451-8.
2003: Francesco Tassone; Fabio Broglio; Silvia Destefanis; Silvia Rovere; Andrea Benso; Cristina Gottero; Flavia Prodam; Ruth Rossetto; Carlotta Gauna; Aart Jan Van der Lely; Ezio Ghigo; Mauro Maccario
Neuroendocrine and metabolic effects of acute ghrelin administration in human obesity.
The Journal of clinical endocrinology and metabolism 2003;88(11):5478-83.
2003: Fabio Broglio; Cristina Gottero; Andrea Benso; Flavia Prodam; Marco Volante; Silvia Destefanis; Carlotta Gauna; Giampiero Muccioli; Mauro Papotti; Aart Jan Van der Lely; Ezio Ghigo
Ghrelin and the endocrine pancreas.
Endocrine 2003;22(1):19-24.
2003: Aart Jan Van der Lely
Hormone use and abuse: what is the difference between hormones as fountain of youth and doping in sports?
Journal of endocrinological investigation 2003;26(9):932-6.
2003: Fabio Broglio; Cristina Gottero; Andrea Benso; Flavia Prodam; Silvia Destefanis; Carlotta Gauna; Mauro Maccario; Romano Deghenghi; Aart Jan Van der Lely; Ezio Ghigo
Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans.
The Journal of clinical endocrinology and metabolism 2003;88(9):4268-72.
2003: Werner F Blum; Elena P Shavrikova; David J Edwards; Myriam Rosilio; Mark L Hartman; Fernando Marin; Domenico Valle; Aart Jan Van der Lely; Andrea F Attanasio; Christian J Strasburger; Gerhard Henrich; Peter Herschbach
Decreased quality of life in adult patients with growth hormone deficiency compared with general populations using the new, validated, self-weighted questionnaire, questions on life satisfaction hypopituitarism module.
The Journal of clinical endocrinology and metabolism 2003;88(9):4158-67.
2003: Virgil A S H Dalm; P Martin van Hagen; Peter M Van Koetsveld; Samuel achilefu; Adriaan B Houtsmuller; David H J Pols; Aart Jan Van der Lely; Steven W J Lamberts; Leo J Hofland
Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells.
American journal of physiology. Endocrinology and metabolism 2003;285(2):E344-53.
2003: Andrea Benso; Cristina Gottero; Flavia Prodam; Carlotta Gauna; Silvia Destefanis; L Filtri; Aart Jan Van der Lely; Romano Deghenghi; Ezio Ghigo; Fabio Broglio
Effects of cortistatin-14 and somatostatin-14 on the endocrine response to hexarelin in humans.
Journal of endocrinological investigation 2003;26(7):599-603.
2003: Joop A M J L Janssen; Aart Jan Van der Lely; Steven W J Lamberts
Circulating free insulin-like growth-factor-I (IGF-I) levels should also be measured to estimate the IGF-I bioactivity.
Journal of endocrinological investigation 2003;26(6):588-94.
2003: Wouter W de Herder; Aart Jan Van der Lely
Addisonian crisis and relative adrenal failure.
Reviews in endocrine & metabolic disorders 2003;4(2):143-7.
2003: Aart Jan Van der Lely; Wouter W de Herder; Eric P Krenning; Dik J Kwekkeboom
Octreoscan radioreceptor imaging.
Endocrine 2003;20(3):307-11.
2003: Fabio Broglio; Andrea Benso; Carlotta Castiglioni; Cristina Gottero; Flavia Prodam; Silvia Destefanis; Carlotta Gauna; Aart Jan Van der Lely; Romano Deghenghi; Mario Bo; Emanuela Arvat; Ezio Ghigo
The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects.
The Journal of clinical endocrinology and metabolism 2003;88(4):1537-42.
2003: Fabio Broglio; Andrea Benso; Cristina Gottero; Flavia Prodam; Carlotta Gauna; L Filtri; Emanuela Arvat; Aart Jan Van der Lely; Romano Deghenghi; Ezio Ghigo
Non-acylated ghrelin does not possess the pituitaric and pancreatic endocrine activity of acylated ghrelin in humans.
Journal of endocrinological investigation 2003;26(3):192-6.
2003: Virgil A S H Dalm; P Martin van Hagen; Peter M Van Koetsveld; Anton Langerak; Aart Jan Van der Lely; Steven W J Lamberts; Leo J Hofland
Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system.
The Journal of clinical endocrinology and metabolism 2003;88(1):270-6.
2003: Richard A Feelders; Steven W J Lamberts; Leo J Hofland; Peter M Van Koetsveld; Miriam Verhoef-Post; Axel P N Themmen; Frank de Jong; H Jaap Bonjer; Adrian J Clark; Aart Jan Van der Lely; Wouter W de Herder
Luteinizing hormone (LH)-responsive Cushing's syndrome: the demonstration of LH receptor messenger ribonucleic acid in hyperplastic adrenal cells, which respond to chorionic gonadotropin and serotonin agonists in vitro.
The Journal of clinical endocrinology and metabolism 2003;88(1):230-7.
2003: Fabio Broglio; Cristina Gottero; Andrea Benso; Flavia Prodam; Felipe F Casanueva; Carlos Dieguez; Aart Jan Van der Lely; Romano Deghenghi; Emanuela Arvat; Ezio Ghigo
Acetylcholine does not play a major role in mediating the endocrine responses to ghrelin, a natural ligand of the GH secretagogue receptor, in humans.
Clinical endocrinology 2003;58(1):92-8.
2002: Aart Jan Van der Lely
The future of growth hormone antagonists.
Current opinion in pharmacology 2002;2(6):730-3.
2002: Fabio Broglio; Peter van Koetsveld Pv; Andrea Benso; Cristina Gottero; Flavia Prodam; Mauro Papotti; Giampiero Muccioli; Carlotta Gauna; Leo J Hofland; Romano Deghenghi; Emanuela Arvat; Aart Jan Van der Lely; Ezio Ghigo
Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans.
The Journal of clinical endocrinology and metabolism 2002;87(10):4829-32.
2002: Fabio Broglio; Emanuela Arvat; Andrea Benso; Cristina Gottero; Flavia Prodam; Silvia Grottoli; Mauro Papotti; Giampiero Muccioli; Aart Jan Van der Lely; Romano Deghenghi; Ezio Ghigo
Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans.
The Journal of clinical endocrinology and metabolism 2002;87(8):3783-90.
2002: Fanny M van der Toorn; Joop A M J L Janssen; Wouter W de Herder; Fabio Broglio; Ezio Ghigo; Aart Jan Van der Lely
Central ghrelin production does not substantially contribute to systemic ghrelin concentrations: a study in two subjects with active acromegaly.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(2):195-9.
2002: Gianluca Aimaretti; Claudia Baffoni; Fabio Broglio; Joop A M J L Janssen; Ginevra Corneli; Romano Deghenghi; Aart Jan Van der Lely; Ezio Ghigo; Emanuela Arvat
Endocrine responses to ghrelin in adult patients with isolated childhood-onset growth hormone deficiency.
Clinical endocrinology 2002;56(6):765-71.
2002: Steven W J Lamberts; Aart Jan Van der Lely; Leo J Hofland
New somatostatin analogs: will they fulfil old promises?
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(5):701-5.
2002: Alex F Muller; Steven W J Lamberts; Joop A M J L Janssen; Leo J Hofland; Peter Van Koetsveld; Martin Bidlingmaier; Christian J Strasburger; Ezio Ghigo; Aart Jan Van der Lely
Ghrelin drives GH secretion during fasting in man.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(2):203-7.
2001: Aart Jan Van der Lely; R K Hutson; Peter J Trainer; G M Besser; Ariel L Barkan; Laurence Katznelson; Anne Klibanski; VS Herman-Bonert; Shlomo Melmed; Mary Lee Vance; Pamela U Freda; P M Stewart; Keith E Friend; David R Clemmons; G Johannsson; Stavros Stavrou; David M Cook; Lawrence S Phillips; Christian J Strasburger; S Hackett; KA Zib; R J Davis; JA Scarlett; M O Thorner
Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist.
Lancet 2001;358(9295):1754-9.
2001: Alex F Muller; F W Leebeek; Joop A M J L Janssen; Steven W J Lamberts; Leo J Hofland; Aart Jan Van der Lely
Acute effect of pegvisomant on cardiovascular risk markers in healthy men: implications for the pathogenesis of atherosclerosis in GH deficiency.
The Journal of clinical endocrinology and metabolism 2001;86(11):5165-71.
2001: Alex F Muller; Joop A M J L Janssen; Steven W J Lamberts; Martin Bidlingmaier; Christian J Strasburger; Leo J Hofland; Aart Jan Van der Lely
Effects of fasting and pegvisomant on the GH-releasing hormone and GH-releasing peptide-6 stimulated growth hormone secretion.
Clinical endocrinology 2001;55(4):461-7.
2001: Fabio Broglio; Emanuela Arvat; Andrea Benso; Cristina Gottero; Giampiero Muccioli; Mauro Papotti; Aart Jan Van der Lely; Romano Deghenghi; Ezio Ghigo
Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans.
The Journal of clinical endocrinology and metabolism 2001;86(10):5083-6.
2001: Alex F Muller; Joop A M J L Janssen; Leo J Hofland; Steven W J Lamberts; Martin Bidlingmaier; Christian J Strasburger; Aart Jan Van der Lely
Blockade of the growth hormone (GH) receptor unmasks rapid GH-releasing peptide-6-mediated tissue-specific insulin resistance.
The Journal of clinical endocrinology and metabolism 2001;86(2):590-3.
2001: Aart Jan Van der Lely; A Muller; Joop A M J L Janssen; R J Davis; KA Zib; JA Scarlett; Steven W J Lamberts
Control of tumor size and disease activity during cotreatment with octreotide and the growth hormone receptor antagonist pegvisomant in an acromegalic patient.
The Journal of clinical endocrinology and metabolism 2001;86(2):478-81.
2001: Alex F Muller; Joop A M J L Janssen; Wouter W de Herder; Aart Jan Van der Lely
[Growth hormone receptor antagonists: potential indications].
Nederlands tijdschrift voor geneeskunde 2001;145(2):69-73.
2000: Aart Jan Van der Lely; Steven W J Lamberts; K W Jauch; Bart A Swierstra; H Hertlein; D Danielle De Vries; Martin Birkett; Peter C Bates; Werner F Blum; Andrea F Attanasio
Use of human GH in elderly patients with accidental hip fracture.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(5):585-92.
2000: Diego Ferone; Annamaria Colao; Aart Jan Van der Lely; Steven W J Lamberts
Pharmacotherapy or surgery as primary treatment for acromegaly?
Drugs & aging 2000;17(2):81-92.
1999: Aart Jan Van der Lely; Wouter W de Herder; Steven W J Lamberts
New medical treatment for acromegaly.
Pituitary 1999;2(1):89-92.
1998: Steven W J Lamberts; Wouter W de Herder; Aart Jan Van der Lely
Pituitary insufficiency.
Lancet 1998;352(9122):127-34.
1998: Nannette A T M Huizenga; P de Lange; Jan W Koper; R N Clayton; W E Farrell; Aart Jan Van der Lely; Albert O Brinkmann; Frank de Jong; Steven W J Lamberts
Human adrenocorticotropin-secreting pituitary adenomas show frequent loss of heterozygosity at the glucocorticoid receptor gene locus.
The Journal of clinical endocrinology and metabolism 1998;83(3):917-21.
1998: Aart Jan Van der Lely; JM Janssen; Steven W J Lamberts
Adult vs childhood onset GHD: is there a real clinical difference?
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1998;8 Suppl A():21-3.
1997: Saskia M T H ten Have; Aart Jan Van der Lely; Steven W J Lamberts
Increase in haemoglobin concentrations in growth hormone deficient adults during human recombinant growth hormone replacement therapy.
Clinical endocrinology 1997;47(5):565-70.
1997: Aart Jan Van der Lely; Wouter W de Herder; Steven W J Lamberts
A risk-benefit assessment of octreotide in the treatment of acromegaly.
Drug safety : an international journal of medical toxicology and drug experience 1997;17(5):317-24.
1997: Steven W J Lamberts; Annewieke W van den Beld; Aart Jan Van der Lely
The endocrinology of aging.
Science (New York, N.Y.) 1997;278(5337):419-24.
1997: Maarten O van Aken; Siem de Marie; Aart Jan Van der Lely; R Singh; J H van den Berge; R M L Poublon; W J Fokkens; Steven W J Lamberts; Wouter W de Herder
Risk factors for meningitis after transsphenoidal surgery.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1997;25(4):852-6.
1997: Joop A M J L Janssen; M L Jacobs; Frans H M Derkx; R F A Weber; Aart Jan Van der Lely; Steven W J Lamberts
Free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 (IGFBP-1), and IGFBP-3 and their relationships to the presence of diabetic retinopathy and glomerular hyperfiltration in insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1997;82(9):2809-15.