Tom van der Poll

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van der Poll Tom; Opal Steven M
Pathogenesis, treatment, and prevention of pneumococcal pneumonia.
Leendertse Masja; Heikens Esther; Wijnands Lucas M; van Luit-Asbroek Miranda; Teske Gwendoline J D; Roelofs Joris J T H; Bonten Marc J M; van der Poll Tom; Willems Rob J L
Enterococcal surface protein transiently aggravates Enterococcus faecium-induced urinary tract infection in mice.
van der Windt Gerritje J W; Wieland Catharina W; Wiersinga Willem J; Florquin Sandrine; van der Poll Tom
Osteopontin is not crucial to protective immunity during murine tuberculosis.

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All Publications

2009: van der Poll Tom; Opal Steven M
Pathogenesis, treatment, and prevention of pneumococcal pneumonia.
Lancet 2009;374(9700):1543-56.
2009: Leendertse Masja; Heikens Esther; Wijnands Lucas M; van Luit-Asbroek Miranda; Teske Gwendoline J D; Roelofs Joris J T H; Bonten Marc J M; van der Poll Tom; Willems Rob J L
Enterococcal surface protein transiently aggravates Enterococcus faecium-induced urinary tract infection in mice.
The Journal of infectious diseases 2009;200(7):1162-5.
2009: van der Windt Gerritje J W; Wieland Catharina W; Wiersinga Willem J; Florquin Sandrine; van der Poll Tom
Osteopontin is not crucial to protective immunity during murine tuberculosis.
Immunology 2009;128(1 Suppl):e766-76.
2009: van Zoelen Marieke A D; Schmidt Ann-Marie; Florquin Sandrine; Meijers Joost C; de Beer Regina; de Vos Alex F; Nawroth Peter P; Bierhaus Angelika; van der Poll Tom
Receptor for advanced glycation end products facilitates host defense during Escherichia coli-induced abdominal sepsis in mice.
The Journal of infectious diseases 2009;200(5):765-73.
2009: Leendertse Masja; Willems Rob J L; Oei G Anneke; Florquin Sandrine; Bonten Marc J M; van der Poll Tom
Intestinal Enterococcus faecium colonization improves host defense during polymicrobial peritonitis.
The Journal of infectious diseases 2009;200(5):735-44.
2009: van Zoelen Marieke A D; van der Sluijs Koenraad F; Achouiti Ahmed; Florquin Sandrine; Braun-Pater Jennie M; Yang Huan; Nawroth Peter P; Tracey Kevin J; Bierhaus Angelika; van der Poll Tom
Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia.
Virology 2009;391(2):265-73.
2009: Leendertse Masja; Willems Rob J L; Giebelen Ida A J; van den Pangaart Petra S; Bonten Marc J M; van der Poll Tom
The acute-phase response impairs host defence against Enterococcus faecium peritonitis.
Immunology 2009;128(1 Suppl):e335-42.
2009: Vergouwen Mervyn D I; Meijers Joost C M; Geskus Ronald B; Coert Bert A; Horn Janneke; Stroes Erik S G; van der Poll Tom; Vermeulen Marinus; Roos Yvo B W E M
Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled randomized trial.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(8):1444-53.
2009: de Vos Alex F; Pater Jennie M; van den Pangaart Petra S; de Kruif Martijn D; van 't Veer Cornelis; van der Poll Tom
In vivo lipopolysaccharide exposure of human blood leukocytes induces cross-tolerance to multiple TLR ligands.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):533-42.
2009: Wiersinga W Joost; van der Poll Tom
Burkholderia pseudomallei tropism and the melioidosis road map.
The Journal of infectious diseases 2009;199(12):1720-2.
2009: van Zoelen Marieke A D; Florquin Sandrine; de Beer Regina; Pater Jennie M; Verstege Marleen I; Meijers Joost C M; van der Poll Tom
Urokinase plasminogen activator receptor-deficient mice demonstrate reduced hyperoxia-induced lung injury.
The American journal of pathology 2009;174(6):2182-9.
2009: Hovius Joppe W R; Bijlsma Maarten F; van der Windt Gerritje J W; Wiersinga W Joost; Boukens Bastiaan J D; Coumou Jeroen; Oei Anneke; de Beer Regina; de Vos Alex F; van 't Veer Cornelis; van Dam Alje P; Wang Penghua; Fikrig Erol; Levi Marcel M; Roelofs Joris J T H; van der Poll Tom
The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi.
PLoS pathogens 2009;5(5):e1000447.
2009: Leendertse Masja; Willems Rob J; Giebelen Ida A; Florquin Sandrine; van den Pangaart Petra S; Bonten Marc J; van der Poll Tom
Cecal ligation and puncture induced sepsis impairs host defense against Enterococcus faecium peritonitis.
Intensive care medicine 2009;35(5):924-32.
2009: Schultz Marcus J; Juffermans Nicole P; van der Poll Tom
A new twist on the legend of granulocyte colony-stimulating factor in acute lung injury?
Critical care medicine 2009;37(4):1506-7.
2009: van Zoelen Marieke A D; Schouten Marcel; de Vos Alex F; Florquin Sandrine; Meijers Joost C M; Nawroth Peter P; Bierhaus Angelika; van der Poll Tom
The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4349-56.
2009: Wieland Catharina W; van der Windt Gerritje J W; Florquin Sandrine; McKenzie Andrew N J; van der Poll Tom
ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis.
Microbes and infection / Institut Pasteur 2009;11(4):524-30.
2009: Wiersinga Willem J; van der Poll Tom
Immunity to Burkholderia pseudomallei.
Current opinion in infectious diseases 2009;22(2):102-8.
2009: Roelofs Joris J T H; Rouschop Kasper M A; Teske Gwendoline J D; Wagenaar Gerry T M; Claessen Nike; Weening Jan J; van der Poll Tom; Florquin Sandrine
Endogenous tissue-type plasminogen activator is protective during ascending urinary tract infection.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(3):801-8.
2009: Wolthuis Esther K; Vlaar Alexander P J; Choi Goda; Roelofs Joris J T H; Haitsma Jack J; van der Poll Tom; Juffermans Nicole P; Zweers Machteld M; Schultz Marcus J
Recombinant human soluble tumor necrosis factor-alpha receptor fusion protein partly attenuates ventilator-induced lung injury.
Shock (Augusta, Ga.) 2009;31(3):262-6.
2009: Leendertse Masja; Willems Rob J L; Giebelen Ida A J; Roelofs Joris J T H; van Rooijen Nico; Bonten Marc J M; van der Poll Tom
Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice.
Innate immunity 2009;15(1):3-12.
2009: Wiersinga Willem Joost; van't Veer Cornelis; van den Pangaart Petra S; Dondorp Arjen M; Day Nicholas P; Peacock Sharon J; van der Poll Tom
Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis).
Critical care medicine 2009;37(2):569-76.
2009: Stegenga Michiel E; Florquin Sandrine; de Vos Alex F; van der Poll Tom
The thiazolidinedione ciglitazone reduces bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice.
Critical care medicine 2009;37(2):614-8.
2009: Hoogerwerf Jacobien J; de Vos Alex F; Levi Marcel; Bresser Paul; van der Zee Jaring S; Draing Christian; von Aulock Sonja; van der Poll Tom
Activation of coagulation and inhibition of fibrinolysis in the human lung on bronchial instillation of lipoteichoic acid and lipopolysaccharide.
Critical care medicine 2009;37(2):619-25.
2009: van der Crabben Saskia N; Blümer Regje M E; Stegenga Michiel E; Ackermans Mariëtte T; Endert Erik; Tanck Michael W T; Serlie Mireille J; van der Poll Tom; Sauerwein Hans P
Early endotoxemia increases peripheral and hepatic insulin sensitivity in healthy humans.
The Journal of clinical endocrinology and metabolism 2009;94(2):463-8.
2009: Giebelen I A J; Leendertse M; Florquin S; van der Poll T
Stimulation of acetylcholine receptors impairs host defence during pneumococcal pneumonia.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(2):375-81.
2009: van Maanen Marjolein A; Lebre Maria C; van der Poll Tom; LaRosa Gregory J; Elbaum Daniel; Vervoordeldonk Margriet J; Tak Paul P
Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice.
Arthritis and rheumatism 2009;60(1):114-22.
2009: Leendertse Masja; Willems Rob J L; Giebelen Ida A J; Roelofs Joris J T H; Top Janetta; Bonten Marc J M; van der Poll Tom
Intestinal colonization with enterococcus faecium does not influence pulmonary defense against Pseudomonas aeruginosa in mice.
PloS one 2009;4(8):e6775.
2009: Wagenaar Jiri F P; Gasem M Hussein; Goris Marga G A; Leeflang Mariska; Hartskeerl Rudy A; van der Poll Tom; van 't Veer Cornelis; van Gorp Eric C M
Soluble ST2 Levels Are Associated with Bleeding in Patients with Severe Leptospirosis.
PLoS neglected tropical diseases 2009;3(6):e453.
2009: Leemans Jaklien C; Butter Loes M; Pulskens Wilco P C; Teske Gwendoline J D; Claessen Nike; van der Poll Tom; Florquin Sandrine
The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury.
PloS one 2009;4(5):e5704.
2009: Yende Sachin; van der Poll Tom
Diabetes and sepsis outcomes--it is not all bad news.
Critical care (London, England) 2009;13(1):117.
2009: Heikens Esther; Leendertse Masja; Wijnands Lucas M; van Luit-Asbroek Miranda; Bonten Marc J M; van der Poll Tom; Willems Rob J L
Enterococcal surface protein Esp is not essential for cell adhesion and intestinal colonization of Enterococcus faecium in mice.
BMC microbiology 2009;9():19.
2008: Levi Marcel; Schouten Marcel; van der Poll Tom
Sepsis, coagulation, and antithrombin: old lessons and new insights.
Seminars in thrombosis and hemostasis 2008;34(8):742-6.
2008: Veninga Henrike; Becker Susann; Hoek Robert M; Wobus Manja; Wandel Elke; van der Kaa Jos; van der Valk Martin; de Vos Alex F; Haase Hannelore; Owens Bronwyn; van der Poll Tom; van Lier René A W; Verbeek J Sjef; Aust Gabriela; Hamann Jörg
Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6574-83.
2008: Wiersinga W Joost; de Vos Alex F; Wieland Catharina W; Leendertse Masja; Roelofs Joris J T H; van der Poll Tom
CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice.
The Journal of infectious diseases 2008;198(9):1388-97.
2008: Hovius J W; Schuijt T J; de Groot K A; Roelofs J J T H; Oei G A; Marquart J A; de Beer R; van 't Veer C; van der Poll T; Ramamoorthi N; Fikrig E; van Dam A P
Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva.
The Journal of infectious diseases 2008;198(8):1189-97.
2008: Wieland Catharina W; van der Windt Gerritje J W; Wiersinga W Joost; Florquin Sandrine; van der Poll Tom
CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
Immunology 2008;125(2):272-9.
2008: Giebelen Ilona A J; Le Moine Alain; van den Pangaart Petra S; Sadis Claude; Goldman Michel; Florquin Sandrine; van der Poll Tom
Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis.
The Journal of infectious diseases 2008;198(5):750-7.
2008: Blümer Regje M E; van der Crabben Saskia N; Stegenga Michiel E; Tanck Michael W; Ackermans Mariette T; Endert Erik; van der Poll Tom; Sauerwein Hans P
Hyperglycemia prevents the suppressive effect of hyperinsulinemia on plasma adiponectin levels in healthy humans.
American journal of physiology. Endocrinology and metabolism 2008;295(3):E613-7.
2008: Giebelen Ida A J; Leendertse Masja; Dessing Mark C; Meijers Joost C M; Levi Marcel; Draing Christian; von Aulock Sonja; van der Poll Tom
Endogenous beta-adrenergic receptors inhibit lipopolysaccharide-induced pulmonary cytokine release and coagulation.
American journal of respiratory cell and molecular biology 2008;39(3):373-9.
2008: van Westerloo David J; Rauws Erik A; Hommes Daan; de Vos Alex F; van der Poll Tom; Powers Barbara L; Fockens Paul; Dijkgraaf Marcel G W; Bruno Marco J
Pre-ERCP infusion of semapimod, a mitogen-activated protein kinases inhibitor, lowers post-ERCP hyperamylasemia but not pancreatitis incidence.
Gastrointestinal endoscopy 2008;68(2):246-54.
2008: Levi Marcel; van der Poll Tom
The role of natural anticoagulants in the pathogenesis and management of systemic activation of coagulation and inflammation in critically ill patients.
Seminars in thrombosis and hemostasis 2008;34(5):459-68.
2008: Wiersinga W Joost; Dessing Mark C; van der Poll Tom
Gene-expression profiles in murine melioidosis.
Microbes and infection / Institut Pasteur 2008;10(8):868-77.
2008: Hoogerwerf Jacobien J; de Vos Alex F; Bresser Paul; van der Zee Jaring S; Pater Jennie M; de Boer Anita; Tanck Michael; Lundell Daniel L; Her-Jenh Chung; Draing Christian; von Aulock Sonja; van der Poll Tom
Lung inflammation induced by lipoteichoic acid or lipopolysaccharide in humans.
American journal of respiratory and critical care medicine 2008;178(1):34-41.
2008: Stegenga Michiel E; van der Crabben Saskia N; Blümer Regje M E; Levi Marcel; Meijers Joost C M; Serlie Mireille J; Tanck Michael W T; Sauerwein Hans P; van der Poll Tom
Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia.
Blood 2008;112(1):82-9.
2008: van't Veer Cornelis; van der Poll Tom
Keeping blood clots at bay in sepsis.
Nature medicine 2008;14(6):606-8.
2008: Hardenberg Gijs; van der Sluijs Koen; van der Poll Tom; Medema Jan Paul
APRIL affects antibody responses and early leukocyte infiltration, but not influenza A viral control.
Molecular immunology 2008;45(11):3050-8.
2008: Leendertse Masja; Willems Rob J L; Giebelen Ida A J; van den Pangaart Petra S; Wiersinga W Joost; de Vos Alex F; Florquin Sandrine; Bonten Marc J M; van der Poll Tom
TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4865-74.
2008: van Zoelen Marieke A D; Ishizaka Akitoshi; Wolthuls Esther K; Choi Goda; van der Poll Tom; Schultz Marcus J
Pulmonary levels of high-mobility group box 1 during mechanical ventilation and ventilator-associated pneumonia.
Shock (Augusta, Ga.) 2008;29(4):441-5.
2008: Renckens R; Roelofs J J T H; Stegenga M E; Florquin S; Levi M; Carmeliet P; Van't Veer C; van der Poll T
Transgenic tissue-type plasminogen activator expression improves host defense during Klebsiella pneumonia.
Journal of thrombosis and haemostasis : JTH 2008;6(4):660-8.
2008: Appelmelk B J; den Dunnen J; Driessen N N; Ummels R; Pak M; Nigou J; Larrouy-Maumus G; Gurcha S S; Movahedzadeh F; Geurtsen J; Brown E J; Eysink Smeets M M; Besra G S; Willemsen P T J; Lowary T L; van Kooyk Y; Maaskant J J; Stoker N G; van der Ley P; Puzo G; Vandenbroucke-Grauls C M J E; Wieland C W; van der Poll T; Geijtenbeek T B H; van der Sar A M; Bitter W
The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction.
Cellular microbiology 2008;10(4):930-44.
2008: de Kruif Martijn D; Lemaire Luclenne C; Giebelen Ida A; Groot Angelique P; Pater Jennie M; van den Pangaart Petra S; Elliott Peter J; van der Poll Tom
Effects of prednisolone on the systemic release of mediators of cell-mediated cytotoxicity during human endotoxemia.
Shock (Augusta, Ga.) 2008;29(4):458-61.
2008: Knapp Sylvia; von Aulock Sonja; Leendertse Masja; Haslinger Isabella; Draing Christian; Golenbock Douglas T; van der Poll Tom
Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3478-84.
2008: van Zoelen Marieke A D; Florquin Sandrine; Meijers Joost C M; de Beer Regina; de Vos Alex F; de Boer Onno J; van der Poll Tom
Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3357-65.
2008: de Kruif Martijn D; Lemaire Lucienne C; Giebelen Ida A; Struck Joachim; Morgenthaler Nils G; Papassotiriou Jana; Elliott Peter J; van der Poll Tom
The influence of corticosteroids on the release of novel biomarkers in human endotoxemia.
Intensive care medicine 2008;34(3):518-22.
2008: Schouten Marcel; Wiersinga Willem Joost; Levi Marcel; van der Poll Tom
Inflammation, endothelium, and coagulation in sepsis.
Journal of leukocyte biology 2008;83(3):536-45.
2008: Hovius Joppe W R; de Jong Marein A W P; den Dunnen Jeroen; Litjens Manja; Fikrig Erol; van der Poll Tom; Gringhuis Sonja I; Geijtenbeek Teunis B H
Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization.
PLoS pathogens 2008;4(2):e31.
2008: Renckens Rosemarijn; van Westerloo David J; Roelofs Joris J T H; Pater Jennie M; Schultz Marcus J; Florquin Sandrine; van der Poll Tom
Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice.
Critical care medicine 2008;36(2):580-7.
2008: Dessing Mark C; Schouten Marcel; Draing Christian; Levi Marcel; von Aulock Sonja; van der Poll Tom
Role played by Toll-like receptors 2 and 4 in lipoteichoic acid-induced lung inflammation and coagulation.
The Journal of infectious diseases 2008;197(2):245-52.
2008: Wolthuis Esther K; Choi Goda; Dessing Mark C; Bresser Paul; Lutter Rene; Dzoljic Misa; van der Poll Tom; Vroom Margreeth B; Hollmann Markus; Schultz Marcus J
Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury.
Anesthesiology 2008;108(1):46-54.
2008: Choi Goda; Hofstra Jorrit-Jan H; Roelofs Joris J T H; Rijneveld Anita W; Bresser Paul; van der Zee Jaring S; Florquin Sandrine; van der Poll Tom; Levi Marcel; Schultz Marcus J
Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats.
Critical care medicine 2008;36(1):204-10.
2008: van der Poll Tom; Opal Steven M
Host-pathogen interactions in sepsis.
The Lancet infectious diseases 2008;8(1):32-43.
2008: Wiersinga W J; Meijers J C M; Levi M; Van 't Veer C; Day N P; Peacock S J; van der Poll T
Activation of coagulation with concurrent impairment of anticoagulant mechanisms correlates with a poor outcome in severe melioidosis.
Journal of thrombosis and haemostasis : JTH 2008;6(1):32-9.
2008: Dessing Mark C; Florquin Sandrine; Paton James C; van der Poll Tom
Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci.
Cellular microbiology 2008;10(1):237-46.
2008: Wiersinga W Joost; de Vos Alex F; de Beer Regina; Wieland Catharina W; Roelofs Joris J T H; Woods Donald E; van der Poll Tom
Inflammation patterns induced by different Burkholderia species in mice.
Cellular microbiology 2008;10(1):81-7.
2008: van der Poll Tom
Tissue factor as an initiator of coagulation and inflammation in the lung.
Critical care (London, England) 2008;12 Suppl 6():S3.
2008: Pulskens Wilco P; Teske Gwendoline J; Butter Loes M; Roelofs Joris J; van der Poll Tom; Florquin Sandrine; Leemans Jaklien C
Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury.
PloS one 2008;3(10):e3596.
2008: Wiersinga W Joost; Wieland Catharina W; Roelofs Joris J T H; van der Poll Tom
MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei.
PloS one 2008;3(10):e3494.
2008: van Zoelen Marieke A D; van der Poll Tom
Targeting RAGE in sepsis.
Critical care (London, England) 2008;12(1):103.
2007: Wiersinga W Joost; Veer Cees van T; Wieland Catharina W; Gibot Sebastien; Hooibrink Berend; Day Nicholas P; Peacock Sharon J; van der Poll Tom
Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis.
The Journal of infectious diseases 2007;196(11):1707-16.
2007: van Zoelen Marieke A D; Laterre Pierre-François; van Veen Suzanne Q; van Till Jan W O; Wittebole Xavier; Bresser Paul; Tanck Michael W; Dugernier Thierry; Ishizaka Akitoshi; Boermeester Marja A; van der Poll Tom
Systemic and local high mobility group box 1 concentrations during severe infection.
Critical care medicine 2007;35(12):2799-804.
2007: Dessing Mark C; van der Sluijs Koenraad F; Florquin Sandrine; van der Poll Tom
Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia.
Clinical immunology (Orlando, Fla.) 2007;125(3):328-36.
2007: Giebelen Ida A J; van Westerloo David J; LaRosa Gregory J; de Vos Alex F; van der Poll Tom
Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung.
Shock (Augusta, Ga.) 2007;28(6):700-3.
2007: van 't Veer Cornelis; van den Pangaart Petra S; van Zoelen Marieke A D; de Kruif Martijn; Birjmohun Rakesh S; Stroes Eric S; de Vos Alex F; van der Poll Tom
Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):7110-20.
2007: van Zoelen Marieke A D; de Vos Alex F; Larosa Gregory J; Draing Christian; von Aulock Sonja; van der Poll Tom
Intrapulmonary delivery of ethyl pyruvate attenuates lipopolysaccharide- and lipoteichoic acid-induced lung inflammation in vivo.
Shock (Augusta, Ga.) 2007;28(5):570-5.
2007: Dessing Mark C; van der Sluijs Koenraad F; Florquin Sandrine; van der Poll Tom
CD14 plays a limited role during influenza A virus infection in vivo.
Immunology letters 2007;113(1):47-51.
2007: Wieland Catharina W; Florquin Sandrine; van der Poll Tom
Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae.
Infection and immunity 2007;75(10):5068-72.
2007: Wiersinga Willem Joost; van der Poll Tom
Is the septic response good or bad?
Current infectious disease reports 2007;9(5):366-73.
2007: Vogl Thomas; Tenbrock Klaus; Ludwig Stephan; Leukert Nadja; Ehrhardt Christina; van Zoelen Marieke A D; Nacken Wolfgang; Foell Dirk; van der Poll Tom; Sorg Clemens; Roth Johannes
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock.
Nature medicine 2007;13(9):1042-9.
2007: Choi G; Vlaar A P J; Schouten M; Van't Veer C; van der Poll T; Levi M; Schultz M J
Natural anticoagulants limit lipopolysaccharide-induced pulmonary coagulation but not inflammation.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;30(3):423-8.
2007: Radosevic Katarina; Wieland Catharina W; Rodriguez Ariane; Weverling Gerrit Jan; Mintardjo Ratna; Gillissen Gert; Vogels Ronald; Skeiky Yasir A W; Hone David M; Sadoff Jerald C; van der Poll Tom; Havenga Menzo; Goudsmit Jaap
Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon.
Infection and immunity 2007;75(8):4105-15.
2007: Wiersinga W Joost; Wieland Catharina W; van der Windt Gerritje J W; de Boer Anita; Florquin Sandrine; Dondorp Arjen; Day Nicholas P; Peacock Sharon J; van der Poll Tom
Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis.
Infection and immunity 2007;75(8):3739-46.
2007: Wiersinga W Joost; Wieland Catharina W; Dessing Mark C; Chantratita Narisara; Cheng Allen C; Limmathurotsakul Direk; Chierakul Wirongrong; Leendertse Masja; Florquin Sandrine; de Vos Alex F; White Nicholas; Dondorp Arjen M; Day Nicholas P; Peacock Sharon J; van der Poll Tom
Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis).
PLoS medicine 2007;4(7):e248.
2007: Zwijnenburg Petra J G; van der Poll Tom; Florquin Sandrine; Polfliet Machteld M J; van den Berg Timo K; Dijkstra Christine D; Roord John J; Hack C Erik; van Furth A Marceline
C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice.
The Journal of infectious diseases 2007;196(1):115-23.
2007: Wiersinga W Joost; Dessing Mark C; Kager Piet A; Cheng Allen C; Limmathurotsakul Direk; Day Nicholas P; Dondorp Arjen M; van der Poll Tom; Peacock Sharon J
High-throughput mRNA profiling characterizes the expression of inflammatory molecules in sepsis caused by Burkholderia pseudomallei.
Infection and immunity 2007;75(6):3074-9.
2007: Choi Goda; Hofstra Jorrit-Jan H; Roelofs Joris J T H; Florquin Sandrine; Bresser Paul; Levi Marcel; van der Poll Tom; Schultz Marcus J
Recombinant human activated protein C inhibits local and systemic activation of coagulation without influencing inflammation during Pseudomonas aeruginosa pneumonia in rats.
Critical care medicine 2007;35(5):1362-8.
2007: Wittkowski Helmut; Sturrock Anne; van Zoelen Marieke A D; Viemann Dorothee; van der Poll Tom; Hoidal John R; Roth Johannes; Foell Dirk
Neutrophil-derived S100A12 in acute lung injury and respiratory distress syndrome.
Critical care medicine 2007;35(5):1369-75.
2007: Birjmohun Rakesh S; van Leuven Sander I; Levels Johannes H M; van 't Veer Cornelis; Kuivenhoven Jan Albert; Meijers Joost C M; Levi Marcel; Kastelein John J P; van der Poll Tom; Stroes Erik S G
High-density lipoprotein attenuates inflammation and coagulation response on endotoxin challenge in humans.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(5):1153-8.
2007: Dessing Mark C; van der Sluijs Koenraad F; Florquin Sandrine; Akira Shizuo; van der Poll Tom
Toll-like receptor 2 does not contribute to host response during postinfluenza pneumococcal pneumonia.
American journal of respiratory cell and molecular biology 2007;36(5):609-14.
2007: Giebelen Ida A J; van Westerloo David J; LaRosa Gregory J; de Vos Alex F; van der Poll Tom
Stimulation of alpha 7 cholinergic receptors inhibits lipopolysaccharide-induced neutrophil recruitment by a tumor necrosis factor alpha-independent mechanism.
Shock (Augusta, Ga.) 2007;27(4):443-7.
2007: De Fost M; Chierakul W; Limpaiboon R; Dondorp A; White N J; van Der Poll T
Release of granzymes and chemokines in Thai patients with leptospirosis.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2007;13(4):433-6.
2007: Hovius Joppe W R; Li Xin; Ramamoorthi Nandhini; van Dam Alje P; Barthold Stephen W; van der Poll Tom; Speelman Peter; Fikrig Erol
Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis.
FEMS immunology and medical microbiology 2007;49(2):224-34.
2007: van Well Gijs Th J; Wieland Catharina W; Florquin Sandrine; Roord John J; van der Poll Tom; van Furth A Marceline
A new murine model to study the pathogenesis of tuberculous meningitis.
The Journal of infectious diseases 2007;195(5):694-7.
2007: Dessing Mark C; Knapp Sylvia; Florquin Sandrine; de Vos Alex F; van der Poll Tom
CD14 facilitates invasive respiratory tract infection by Streptococcus pneumoniae.
American journal of respiratory and critical care medicine 2007;175(6):604-11.
2007: de Kruif Martijn D; Lemaire Lucienne C; Giebelen Ida A; van Zoelen Marieke A D; Pater Jennie M; van den Pangaart Petra S; Groot Angelique P; de Vos Alex F; Elliott Peter J; Meijers Joost C M; Levi Marcel; van der Poll Tom
Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1845-51.
2007: Wieland Catharina W; Koppel Estella A; den Dunnen Jeroen; Florquin Sandrine; McKenzie Andrew N J; van Kooyk Yvette; van der Poll Tom; Geijtenbeek Teunis B H
Mice lacking SIGNR1 have stronger T helper 1 responses to Mycobacterium tuberculosis.
Microbes and infection / Institut Pasteur 2007;9(2):134-41.
2007: Renckens Rosemarijn; Roelofs Joris J T H; Bonta Peter I; Florquin Sandrine; de Vries Carlie J M; Levi Marcel; Carmeliet Peter; van't Veer Cornelis; van der Poll Tom
Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia.
Blood 2007;109(4):1593-601.
2007: Knapp Sylvia; Matt Ulrich; Leitinger Norbert; van der Poll Tom
Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):993-1001.
2007: Maris Nico A; de Vos Alex F; Bresser Paul; van der Zee Jaring S; Jansen Henk M; Levi Marcel; van der Poll Tom
Salmeterol enhances pulmonary fibrinolysis in healthy volunteers.
Critical care medicine 2007;35(1):57-63.
2007: Levi Marcel; van der Poll Tom
Recombinant human activated protein C: current insights into its mechanism of action.
Critical care (London, England) 2007;11 Suppl 5():S3.
2006: van Zoelen Marieke A D; Bakhtiari Kamran; Dessing Mark C; van't Veer Cornelis; Spek C Arnold; Tanck Michael; Meijers Joost C; van der Poll Tom
Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells.
Thrombosis and haemostasis 2006;96(6):789-93.
2006: Renckens Rosemarijn; Pater Jennie M; van der Poll Tom
Plasminogen activator inhibitor type-1-deficient mice have an enhanced IFN-gamma response to lipopolysaccharide and staphylococcal enterotoxin B.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):8171-6.
2006: Roelofs J J T H; Rouschop K M A; Teske G J D; Claessen N; Weening J J; van der Poll T; Florquin S
The urokinase plasminogen activator receptor is crucially involved in host defense during acute pyelonephritis.
Kidney international 2006;70(11):1942-7.
2006: Dessing Mark C; de Vos Alex F; Florquin Sandrine; van der Poll Tom
Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia.
Infection and immunity 2006;74(12):7021-3.
2006: Rouschop Kasper M A; Sylva Marc; Teske Gwendoline J D; Hoedemaeker Inge; Pals Steven T; Weening Jan J; van der Poll Tom; Florquin Sandrine
Urothelial CD44 facilitates Escherichia coli infection of the murine urinary tract.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7225-32.
2006: Keller Tymen T; van der Sluijs Koen F; de Kruif Martijn D; Gerdes Victor E A; Meijers Joost C M; Florquin Sandrine; van der Poll Tom; van Gorp Eric C M; Brandjes Dees P M; Büller Harry R; Levi Marcel
Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen activator inhibitor type 1.
Circulation research 2006;99(11):1261-9.
2006: Wieland Catharina W; Kerver Marjolein E; Florquin Sandrine; Nolte Martijn A; Borst Jannie; van Lier Rene; van Oers Marinus H J; van der Poll Tom
CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome.
International immunology 2006;18(11):1531-9.
2006: Choi Goda; Wolthuis Esther K; Bresser Paul; Levi Marcel; van der Poll Tom; Dzoljic Misa; Vroom Margreeth B; Schultz Marcus J
Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents alveolar coagulation in patients without lung injury.
Anesthesiology 2006;105(4):689-95.
2006: Bonta Peter I; van Tiel Claudia M; Vos Mariska; Pols Thijs W H; van Thienen Johannes V; Ferreira Valérie; Arkenbout E Karin; Seppen Jurgen; Spek C Arnold; van der Poll Tom; Pannekoek Hans; de Vries Carlie J M
Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2288-94.
2006: Maris N A; Dessing M C; de Vos A F; Bresser P; van der Zee J S; Jansen H M; Spek C A; van der Poll T
Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;28(3):622-6.
2006: van Westerloo D J; Giebelen I A J; Meijers J C M; Daalhuisen J; de Vos A F; Levi M; van der Poll T
Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats.
Journal of thrombosis and haemostasis : JTH 2006;4(9):1997-2002.
2006: Wieland Catharina W; Florquin Sandrine; Pater Jennie M; Weijer Sebastiaan; van der Poll Tom
Interleukin-1 contributes to an effective clearance of Mycobacterium kansasii from the respiratory tract.
Microbes and infection / Institut Pasteur 2006;8(9-10):2409-13.
2006: Renckens Rosemarijn; Roelofs Joris J T H; Florquin Sandrine; de Vos Alex F; Pater Jennie M; Lijnen H Roger; Carmeliet Peter; van 't Veer Cornelis; van der Poll Tom
Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1189-96.
2006: Stegenga Michiel E; van der Crabben Saskia N; Levi Marcel; de Vos Alex F; Tanck Michael W; Sauerwein Hans P; van der Poll Tom
Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans.
Diabetes 2006;55(6):1807-12.
2006: Rijneveld Anita W; Weijer Sebastiaan; Bresser Paul; Florquin Sandrine; Vlasuk George P; Rote William E; Spek C Arnold; Reitsma Pieter H; van der Zee Jaring S; Levi Marcel; van der Poll Tom
Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia.
Critical care medicine 2006;34(6):1725-30.
2006: van der Sluijs Koenraad F; van Elden Leontine J R; Xiao Yanling; Arens Ramon; Nijhuis Monique; Schuurman Rob; Florquin Sandrine; Jansen Henk M; Lutter René; van der Poll Tom
IL-12 deficiency transiently improves viral clearance during the late phase of respiratory tract infection with influenza A virus in mice.
Antiviral research 2006;70(2):75-84.
2006: van Westerloo David J; Giebelen Ilona A; Florquin Sandrine; Bruno Marco J; Larosa Gregory J; Ulloa Luis; Tracey Kevin J; van der Poll T
The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice.
Gastroenterology 2006;130(6):1822-30.
2006: Lemaire Lucienne C; de Kruif Martijn D; Giebelen Ida A; Levi Marcel; van der Poll Tom; Heesen Michael
Dobutamine does not influence inflammatory pathways during human endotoxemia.
Critical care medicine 2006;34(5):1365-71.
2006: Wieland Catharina W; Stegenga Michiel E; Florquin Sandrine; Fantuzzi Giamila; van der Poll Tom
Leptin and host defense against Gram-positive and Gram-negative pneumonia in mice.
Shock (Augusta, Ga.) 2006;25(4):414-9.
2006: Weisfelt Martijn; de Gans Jan; van der Poll Tom; van de Beek Diederik
Pneumococcal meningitis in adults: new approaches to management and prevention.
Lancet neurology 2006;5(4):332-42.
2006: Wiersinga W Joost; van der Poll Tom; White Nicholas J; Day Nicholas P; Peacock Sharon J
Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei.
Nature reviews. Microbiology 2006;4(4):272-82.
2006: Choi Goda; Schultz Marcus J; Levi Marcel; van der Poll Tom
The relationship between inflammation and the coagulation system.
Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology 2006;136(9-10):139-44.
2006: Renckens Rosemarijn; Roelofs Joris J T H; Florquin Sandrine; de Vos Alex F; Lijnen H Roger; van't Veer Cornelis; van der Poll Tom
Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3735-41.
2006: Zwijnenburg Petra J G; van der Poll Tom; Roord John J; van Furth A Marceline
Chemotactic factors in cerebrospinal fluid during bacterial meningitis.
Infection and immunity 2006;74(3):1445-51.
2006: Knapp Sylvia; Florquin Sandrine; Golenbock Douglas T; van der Poll Tom
Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3189-95.
2006: Leemans Jaklien C; Wieland Catharina W; Florquin Sandrine; van der Poll Tom; Vervoordeldonk Margriet J B M
Mice overexpressing p40 in lungs have reduced leucocyte influx and slightly impaired resistance during tuberculosis.
Immunology 2006;117(3):409-18.
2006: Levi Marcel; van der Poll Tom; ten Cate Hugo
Tissue factor in infection and severe inflammation.
Seminars in thrombosis and hemostasis 2006;32(1):33-9.
2006: Renckens Rosemarijn; Roelofs Joris J T H; Florquin Sandrine; van der Poll Tom
Urokinase-type plasminogen activator receptor plays a role in neutrophil migration during lipopolysaccharide-induced peritoneal inflammation but not during Escherichia coli-induced peritonitis.
The Journal of infectious diseases 2006;193(4):522-30.
2006: Wieland Catharina W; Florquin Sandrine; Pater Jennie M; Weijer Sebastiaan; van der Poll Tom
CD4+ cells play a limited role in murine lung infection with Mycobacterium kansasii.
American journal of respiratory cell and molecular biology 2006;34(2):167-73.
2006: Heesen Michael; Renckens Rosemarijn; de Vos Alex F; Kunz Dagmar; van der Poll Tom
Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2.
Clinical and vaccine immunology : CVI 2006;13(1):156-9.
2006: van der Sluijs Koenraad F; Nijhuis Monique; Levels Johannes H M; Florquin Sandrine; Mellor Andrew L; Jansen Henk M; van der Poll Tom; Lutter René
Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia.
The Journal of infectious diseases 2006;193(2):214-22.
2006: Renckens Rosemarijn; Roelofs Joris J T H; Knapp Sylvia; de Vos Alex F; Florquin Sandrine; van der Poll Tom
The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia.
The Journal of infectious diseases 2006;193(2):187-95.
2006: Knapp Sylvia; Wieland Catharina W; Florquin Sandrine; Pantophlet Ralph; Dijkshoorn Lenie; Tshimbalanga Ntambua; Akira Shizuo; van der Poll Tom
Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia.
American journal of respiratory and critical care medicine 2006;173(1):122-9.
2006: van der Sluijs Koenraad F; van Elden Leontine J R; Nijhuis Monique; Schuurman Rob; Florquin Sandrine; Shimizu Takao; Ishii Satoshi; Jansen Henk M; Lutter René; van der Poll Tom
Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia.
American journal of physiology. Lung cellular and molecular physiology 2006;290(1):L194-9.
2006: Maris Nico A; Florquin Sandrine; van't Veer Cornelis; de Vos Alex F; Buurman Wim; Jansen Henk M; van der Poll Tom
Inhalation of beta 2 agonists impairs the clearance of nontypable Haemophilus influenzae from the murine respiratory tract.
Respiratory research 2006;7():57.
2006: van Till J W O; Lamme B; van Esch T J H; van der Poll T; van Gulik T M; Boermeester M A
Surgical therapy attenuates abdominal and extra-abdominal inflammation in experimental peritonitis.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2006;38(2):76-82.
2006: Levi Marcel; de Jonge Evert; van der Poll Tom
Plasma and plasma components in the management of disseminated intravascular coagulation.
Best practice & research. Clinical haematology 2006;19(1):127-42.
2005: Knapp Sylvia; Schultz Marcus J; van der Poll Tom
Pneumonia models and innate immunity to respiratory bacterial pathogens.
Shock (Augusta, Ga.) 2005;24 Suppl 1():12-8.
2005: Renckens Rosemarijn; Roelofs Joris J T H; ter Horst Simone A J; van 't Veer Cornelis; Havik Stefan R; Florquin Sandrine; Wagenaar Gerry T M; Meijers Joost C M; van der Poll Tom
Absence of thrombin-activatable fibrinolysis inhibitor protects against sepsis-induced liver injury in mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6764-71.
2005: Wieland Catharina W; Florquin Sandrine; Maris Nico A; Hoebe Kasper; Beutler Bruce; Takeda Kiyoshi; Akira Shizuo; van der Poll Tom
The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):6042-9.
2005: Determann Rogier M; Millo Julian L; Gibot Sébastien; Korevaar Johanna C; Vroom Margreeth B; van der Poll Tom; Garrard Christopher S; Schultz Marcus J
Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia.
Intensive care medicine 2005;31(11):1495-500.
2005: Wieland Catharina W; Florquin Sandrine; Chan Edward D; Leemans Jaklien C; Weijer Sebastiaan; Verbon Annelies; Fantuzzi Giamila; van der Poll Tom
Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice.
International immunology 2005;17(11):1399-408.
2005: Levi Marcel; van der Poll Tom
Two-way interactions between inflammation and coagulation.
Trends in cardiovascular medicine 2005;15(7):254-9.
2005: Leemans Jaklien C; Stokman Geurt; Claessen Nike; Rouschop Kasper M; Teske Gwendoline J D; Kirschning Carsten J; Akira Shizuo; van der Poll Tom; Weening Jan J; Florquin Sandrine
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.
The Journal of clinical investigation 2005;115(10):2894-903.
2005: Rouschop Kasper M A; Roelofs Joris J T H; Rowshani Ajda T; Leemans Jaklien C; van der Poll Tom; Ten Berge Ineke J M; Weening Jan J; Florquin Sandrine
Pre-transplant plasma and cellular levels of CD44 correlate with acute renal allograft rejection.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005;20(10):2248-54.
2005: Koppel Estella A; Wieland Catharina W; van den Berg Venice C M; Litjens Manja; Florquin Sandrine; van Kooyk Yvette; van der Poll Tom; Geijtenbeek Teunis B H
Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection.
European journal of immunology 2005;35(10):2962-9.
2005: Weijer Sebastiaan; Wieland Catharina W; Florquin Sandrine; van der Poll Tom
A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis.
Blood 2005;106(8):2761-8.
2005: Maris Nico A; de Vos Alex F; Dessing Mark C; Spek C Arnold; Lutter Rene; Jansen Henk M; van der Zee Jaring S; Bresser Paul; van der Poll Tom
Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers.
American journal of respiratory and critical care medicine 2005;172(7):878-84.
2005: van Westerloo David J; Knapp Sylvia; van't Veer Cornelis; Buurman Wim A; de Vos Alex F; Florquin Sandrine; van der Poll Tom
Aspiration pneumonitis primes the host for an exaggerated inflammatory response during pneumonia.
Critical care medicine 2005;33(8):1770-8.
2005: Choi G; Schultz M J; Levi M; van der Poll T; Millo J L; Garrard C S
Protein C in pneumonia.
Thorax 2005;60(8):705-6.
2005: Branger Judith; Leemans Jaklien C; Florquin Sandrine; Speelman Peter; Golenbock Douglas T; van der Poll Tom
Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection.
Clinical immunology (Orlando, Fla.) 2005;116(2):174-81.
2005: Maris Nico A; de Vos Alex F; Bresser Paul; van der Zee Jaring S; Meijers Joost C; Lijnen H Roger; Levi Marcel; Jansen Henk M; van der Poll Tom
Activation of coagulation and inhibition of fibrinolysis in the lung after inhalation of lipopolysaccharide by healthy volunteers.
Thrombosis and haemostasis 2005;93(6):1036-40.
2005: van Westerloo David J; Giebelen Ilona A J; Florquin Sandrine; Daalhuisen Joost; Bruno Marco J; de Vos Alex F; Tracey Kevin J; van der Poll Tom
The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis.
The Journal of infectious diseases 2005;191(12):2138-48.
2005: van Westerloo David J; Weijer Sebastiaan; Bruno Marco J; de Vos Alex F; Van't Veer Cornelis; van der Poll Tom
Toll-like receptor 4 deficiency and acute pancreatitis act similarly in reducing host defense during murine Escherichia coli peritonitis.
Critical care medicine 2005;33(5):1036-43.
2005: Renckens R; Roelofs J J T H; de Waard V; Florquin S; Lijnen H R; Carmeliet P; van der Poll T
The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury.
Journal of thrombosis and haemostasis : JTH 2005;3(5):1018-25.
2005: Rijneveld Anita W; de Vos Alex F; Florquin Sandrine; Verbeek J Sjef; van der Poll Tom
CD11b limits bacterial outgrowth and dissemination during murine pneumococcal pneumonia.
The Journal of infectious diseases 2005;191(10):1755-60.
2005: van der Poll Tom; Levi Marcel; Nick Jerry A; Abraham Edward
Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans.
American journal of respiratory and critical care medicine 2005;171(10):1125-8.
2005: de Fost Maaike; Chierakul Wirongrong; Pimda Kriangsak; Dondorp Arjen M; White Nicholas J; Van der Poll Tom
Activation of cytotoxic lymphocytes in patients with scrub typhus.
The American journal of tropical medicine and hygiene 2005;72(4):465-7.
2005: van Westerloo David J; Florquin Sandrine; de Boer Anita M; Daalhuisen Joost; de Vos Alex F; Bruno Marco J; van der Poll Tom
Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice.
The American journal of pathology 2005;166(3):721-8.
2005: van Westerloo David; van der Poll Tom
Acute vagotomy activates the cholinergic anti-inflammatory pathway.
American journal of physiology. Heart and circulatory physiology 2005;288(2):H977-8; author reply H978-9.
2005: Weijer Sebastiaan; Florquin Sandrine; van der Poll Tom
Endogenous interleukin-12 improves the early antimicrobial host response to murine Escherichia coli peritonitis.
Shock (Augusta, Ga.) 2005;23(1):54-8.
2005: Leemans Jaklien C; Thepen Theo; Weijer Sebastiaan; Florquin Sandrine; van Rooijen Nico; van de Winkel Jan G; van der Poll Tom
Macrophages play a dual role during pulmonary tuberculosis in mice.
The Journal of infectious diseases 2005;191(1):65-74.
2004: Knapp Sylvia; Gibot Sébastien; de Vos Alex; Versteeg Henri H; Colonna Marco; van der Poll Tom
Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7131-4.
2004: Branger Judith; Wieland Catharina W; Florquin Sandrine; Maris Nico A; Pater Jennie M; Speelman Peter; Shimizu Takao; Ishii Satoshi; van der Poll Tom
Platelet-activating factor receptor-deficient mice show an unaltered clearance of nontypeable Haemophilus influenzae from their respiratory tract.
Shock (Augusta, Ga.) 2004;22(6):543-7.
2004: Wieland Catharina W; Knapp Sylvia; Florquin Sandrine; de Vos Alex F; Takeda Kiyoshi; Akira Shizuo; Golenbock Douglas T; Verbon Annelies; van der Poll Tom
Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2.
American journal of respiratory and critical care medicine 2004;170(12):1367-74.
2004: Hailu Asrat; van der Poll Tom; Berhe Nega; Kager Piet A
Elevated plasma levels of interferon (IFN)-gamma, IFN-gamma inducing cytokines, and IFN-gamma inducible CXC chemokines in visceral leishmaniasis.
The American journal of tropical medicine and hygiene 2004;71(5):561-7.
2004: Choi G; Schultz M J; van Till J W O; Bresser P; van der Zee J S; Boermeester M A; Levi M; van der Poll T
Disturbed alveolar fibrin turnover during pneumonia is restricted to the site of infection.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(5):786-9.
2004: Branger Judith; Florquin Sandrine; Knapp Sylvia; Leemans Jaklien C; Pater Jennie M; Speelman Peter; Golenbock Douglas T; van der Poll Tom
LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia.
International immunology 2004;16(11):1605-11.
2004: Chierakul Wirongrong; de Fost Maaike; Suputtamongkol Yupin; Limpaiboon Roongreung; Dondorp Arjen; White Nicholas J; van der Poll Tom
Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis.
Clinical immunology (Orlando, Fla.) 2004;113(2):140-4.
2004: van Westerloo David J; Schultz Marcus J; Bruno Marco J; de Vos Alex F; Florquin Sandrine; van der Poll Tom
Acute pancreatitis in mice impairs bacterial clearance from the lungs, whereas concurrent pneumonia prolongs the course of pancreatitis.
Critical care medicine 2004;32(10):1997-2001.
2004: van der Sluijs Koenraad F; van Elden Leontine J R; Nijhuis Monique; Schuurman Rob; Pater Jennie M; Florquin Sandrine; Goldman Michel; Jansen Henk M; Lutter René; van der Poll Tom
IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7603-9.
2004: Levi Marcel; van der Poll Tom; Büller Harry R
Bidirectional relation between inflammation and coagulation.
Circulation 2004;109(22):2698-704.
2004: Weijer Sebastian; Schoenmakers Saskia H H F; Florquin Sandrine; Levi Marcel; Vlasuk George P; Rote William E; Reitsma Pieter H; Spek C Arnold; van der Poll Tom
Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice.
The Journal of infectious diseases 2004;189(12):2308-17.
2004: Maris Nico A; van der Sluijs Koenraad F; Florquin Sandrine; de Vos Alex F; Pater Jennie M; Jansen Henk M; van der Poll Tom
Salmeterol, a beta2-receptor agonist, attenuates lipopolysaccharide-induced lung inflammation in mice.
American journal of physiology. Lung cellular and molecular physiology 2004;286(6):L1122-8.
2004: Levi Marcel; Choi Goda; Schoots Ivo; Schultz Marcus; van der Poll Tom
Beyond sepsis: activated protein C and ischemia-reperfusion injury.
Critical care medicine 2004;32(5 Suppl):S309-12.
2004: Knapp Sylvia; Hareng Lars; Rijneveld Anita W; Bresser Paul; van der Zee Jaring S; Florquin Sandrine; Hartung Thomas; van der Poll Tom
Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumonia.
The Journal of infectious diseases 2004;189(8):1506-15.
2004: van der Poll Tom; Levi Marcel
Mechanisms of action of activated protein C: an evolving story.
Critical care medicine 2004;32(4):1086-7.
2004: Levi Marcel; van der Poll Tom
Coagulation in sepsis: all bugs bite equally.
Critical care (London, England) 2004;8(2):99-100.
2004: Schultz Marcus J; van der Poll Tom
Modulation of innate immune responses in the treatment of sepsis and pneumonia.
Current drug targets. Inflammation and allergy 2004;3(1):11-7.
2004: Knapp Sylvia; Wieland Catharina W; van 't Veer Cornelis; Takeuchi Osamu; Akira Shizuo; Florquin Sandrine; van der Poll Tom
Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):3132-8.
2004: Branger Judith; Leemans Jaklien C; Florquin Sandrine; Weijer Sebastiaan; Speelman Peter; Van Der Poll Tom
Toll-like receptor 4 plays a protective role in pulmonary tuberculosis in mice.
International immunology 2004;16(3):509-16.
2004: Renckens Rosemarijn; Weijer Sebastiaan; de Vos Alex F; Pater Jennie M; Meijers Joost C; Hack C Erik; Levi Marcel; van der Poll Tom
Inhibition of plasmin activity by tranexamic acid does not influence inflammatory pathways during human endotoxemia.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(3):483-8.
2004: Rijneveld Anita W; Weijer Sebastiaan; Florquin Sandrine; Esmon Charles T; Meijers Joost C M; Speelman Peter; Reitsma Pieter H; Ten Cate Hugo; van der Poll Tom
Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide.
Blood 2004;103(5):1702-9.
2004: Rijneveld Anita W; Weijer Sebastiaan; Florquin Sandrine; Speelman Peter; Shimizu Takao; Ishii Satosh; van der Poll Tom
Improved host defense against pneumococcal pneumonia in platelet-activating factor receptor-deficient mice.
The Journal of infectious diseases 2004;189(4):711-6.
2004: Schultz M J; Millo J; Levi M; Hack C E; Weverling G J; Garrard C S; van der Poll T
Local activation of coagulation and inhibition of fibrinolysis in the lung during ventilator associated pneumonia.
Thorax 2004;59(2):130-5.
2004: Branger Judith; Knapp Sylvia; Weijer Sebastiaan; Leemans Jaklien C; Pater Jennie M; Speelman Peter; Florquin Sandrine; van der Poll Tom
Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice.
Infection and immunity 2004;72(2):788-94.
2004: Sewnath Miguel E; van der Poll Tom; van Noorden Cornelis J F; ten Kate Fiebo J W; Gouma Dirk J
Cholestatic interleukin-6-deficient mice succumb to endotoxin-induced liver injury and pulmonary inflammation.
American journal of respiratory and critical care medicine 2004;169(3):413-20.
2004: van den Blink Bernt; Branger Judith; Weijer Sebastiaan; Gupta Abhya; van Deventer Sander J H; Peppelenbosch Maikel P; van der Poll Tom
P38 mitogen activated protein kinase is involved in the downregulation of granulocyte CXC chemokine receptors 1 and 2 during human endotoxemia.
Journal of clinical immunology 2004;24(1):37-41.
2004: de Pont A C J M; Moons A H M; de Jonge E; Meijers J C M; Vlasuk G P; Rote W E; Büller H R; van der Poll T; Levi M
Recombinant nematode anticoagulant protein c2, an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the interleukin-10 response in human endotoxemia.
Journal of thrombosis and haemostasis : JTH 2004;2(1):65-70.
2004: Heesen Michael; Kunz Dagmar; Wessiepe Martina; van der Poll Tom; Zwinderman Aeilko H; Blomeke Brunhilde
Rapid genotyping for tumor necrosis factor-alpha (TNF-alpha)-863C/A promoter polymorphism that determines TNF-alpha response.
Clinical chemistry 2004;50(1):226-8.
2004: Leemans Jaklien C; te Velde Anje A; Florquin Sandrine; Bennink Roelof J; de Bruin Kora; van Lier René A W; van der Poll Tom; Hamann Jörg
The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):1125-31.
2004: Millo Julian L; Schultz Marcus J; Williams Conrad; Weverling Gerrit J; Ringrose Timothy; Mackinlay Carolyn I; van der Poll Tom; Garrard Christopher S
Compartmentalisation of cytokines and cytokine inhibitors in ventilator-associated pneumonia.
Intensive care medicine 2004;30(1):68-74.
2004: Hailu Asrat; Pater Jennie M; Kager Piet A; van der Poll Tom
Increased expression of HIV co-receptor CXCR4 on CD4+ T-cells in patients with active visceral leishmaniasis.
Scandinavian journal of infectious diseases 2004;36(1):56-8.
2004: Levi Marcel; de Jonge Evert; van der Poll Tom
New treatment strategies for disseminated intravascular coagulation based on current understanding of the pathophysiology.
Annals of medicine 2004;36(1):41-9.
2003: Zwijnenburg Petra J G; de Bie Henrica M A; Roord John J; van der Poll Tom; van Furth A Marceline
Chemotactic activity of CXCL5 in cerebrospinal fluid of children with bacterial meningitis.
Journal of neuroimmunology 2003;145(1-2):148-53.
2003: Knapp Sylvia; de Vos Alex F; Florquin Sandrine; Golenbock Douglas T; van der Poll Tom
Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice.
Infection and immunity 2003;71(12):6747-53.
2003: Rijneveld Anita W; Florquin Sandrine; Speelman Peter; Edwards Carl K; Dinarello Charles A; van der Poll Tom
Interleukin-1 receptor antagonist transiently impairs antibacterial defense but not survival in murine pneumococcal pneumonia.
European cytokine network 2003;14(4):242-5.
2003: van der Sluijs Koenraad F; van Elden Leontine; Nijhuis Monique; Schuurman Rob; Florquin Sandrine; Jansen Henk M; Lutter René; van der Poll Tom
Toll-like receptor 4 is not involved in host defense against respiratory tract infection with Sendai virus.
Immunology letters 2003;89(2-3):201-6.
2003: Weijer Sebastiaan; Sewnath Miguel E; de Vos Alex F; Florquin Sandrine; van der Sluis Koen; Gouma Dirk J; Takeda Kiyoshi; Akira Shizuo; van der Poll Tom
Interleukin-18 facilitates the early antimicrobial host response to Escherichia coli peritonitis.
Infection and immunity 2003;71(10):5488-97.
2003: Leemans Jaklien C; Heikens Mirjam; van Kessel Kok P M; Florquin Sandrine; van der Poll Tom
Lipoteichoic acid and peptidoglycan from Staphylococcus aureus synergistically induce neutrophil influx into the lungs of mice.
Clinical and diagnostic laboratory immunology 2003;10(5):950-3.
2003: Levi Marcel; de Jonge Evert; van der Poll Tom
Sepsis and disseminated intravascular coagulation.
Journal of thrombosis and thrombolysis 2003;16(1-2):43-7.
2003: Weijer Sebastiaan; Leemans Jaklien C; Florquin Sandrine; Shimizu Takao; Ishii Satoshi; van der Poll Tom
Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis.
Immunology 2003;109(4):552-6.
2003: Rijneveld Anita W; Florquin Sandrine; Bresser Paul; Levi Marcel; De Waard Vivian; Lijnen Roger; Van Der Zee Jaring S; Speelman Peter; Carmeliet Peter; Van Der Poll Tom
Plasminogen activator inhibitor type-1 deficiency does not influence the outcome of murine pneumococcal pneumonia.
Blood 2003;102(3):934-9.
2003: Olszyna Dariusz P; Verbon Annelies; Pribble John P; Turner Terence; Axtelle Tim; van Deventer Sander J H; van der Poll Tom
Effect of IC14, an anti-CD14 antibody, on plasma and cell-associated chemokines during human endotoxemia.
European cytokine network 2003;14(3):158-62.
2003: Rijneveld Anita W; Florquin Sandrine; Hartung Thomas; Speelman Peter; van der Poll Tom
Anti-tumor necrosis factor antibody impairs the therapeutic effect of ceftriaxone in murine pneumococcal pneumonia.
The Journal of infectious diseases 2003;188(2):282-5.
2003: Levi Marcel; Dörffler-Melly Janine; Reitsma Pieter; Buller Harry; Florquin Sandrine; van der Poll Tom; Carmeliet Peter
Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice.
Blood 2003;101(12):4823-7.
2003: Branger Judith; van den Blink Bernt; Weijer Sebastiaan; Gupta Abhya; van Deventer Sander J H; Hack C Erik; Peppelenbosch Maikel P; van der Poll Tom
Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia.
Blood 2003;101(11):4446-8.
2003: Reitsma P H; Branger J; Van Den Blink B; Weijer S; Van Der Poll T; Meijers J C M
Procoagulant protein levels are differentially increased during human endotoxemia.
Journal of thrombosis and haemostasis : JTH 2003;1(5):1019-23.
2003: Zwijnenburg Petra J G; van der Poll Tom; Florquin Sandrine; Akira Shizuo; Takeda Kiyoshi; Roord John J; van Furth A Marceline
Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis.
Journal of neuroimmunology 2003;138(1-2):31-7.
2003: de Jonge Evert; Friederich Philip W; Vlasuk George P; Rote William E; Vroom Margaretha B; Levi Marcel; van der Poll Tom
Activation of coagulation by administration of recombinant factor VIIa elicits interleukin 6 (IL-6) and IL-8 release in healthy human subjects.
Clinical and diagnostic laboratory immunology 2003;10(3):495-7.
2003: Stordeur Patrick; Zhou Ling; Byl Baudouin; Brohet Fabian; Burny Wivine; de Groote Donat; van der Poll Tom; Goldman Michel
Immune monitoring in whole blood using real-time PCR.
Journal of immunological methods 2003;276(1-2):69-77.
2003: Zwijnenburg Petra J G; van der Poll Tom; Florquin Sandrine; Roord John J; Van Furth A Marceline
IL-1 receptor type 1 gene-deficient mice demonstrate an impaired host defense against pneumococcal meningitis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4724-30.
2003: Schultz Marcus J; Levi Marcel; van der Poll Tom
Anticoagulant therapy for acute lung injury or pneumonia.
Current drug targets 2003;4(4):315-21.
2003: Levi Marcel; Schultz Marcus J; Rijneveld Anita W; van der Poll Tom
Bronchoalveolar coagulation and fibrinolysis in endotoxemia and pneumonia.
Critical care medicine 2003;31(4 Suppl):S238-42.
2003: Zwijnenburg Petra J G; van der Poll Tom; Florquin Sandrine; Roord John J; van Furth A Marceline
Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.
Infection and immunity 2003;71(4):2276-9.
2003: Schultz Marc J; Knapp Sylvia; Florquin Sandrine; Pater Jennie; Takeda Kiyoshi; Akira Shizuo; van der Poll Tom
Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa.
Infection and immunity 2003;71(4):1630-4.
2003: Spek C Arnold; Verbon Annelies; Aberson Hella; Pribble John P; McElgunn Cathal J; Turner Terence; Axtelle Tim; Schouten Jan; Van Der Poll Tom; Reitsma Pieter H
Treatment with an anti-CD14 monoclonal antibody delays and inhibits lipopolysaccharide-induced gene expression in humans in vivo.
Journal of clinical immunology 2003;23(2):132-40.
2003: de Fost Maaike; Hartskeerl Rudy A; Groenendijk Martijn R; van der Poll Tom
Interleukin 12 in part regulates gamma interferon release in human whole blood stimulated with Leptospira interrogans.
Clinical and diagnostic laboratory immunology 2003;10(2):332-5.
2003: Leemans Jaklien C; Florquin Sandrine; Heikens Mirjam; Pals Steven T; van der Neut Ronald; Van Der Poll Tom
CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis.
The Journal of clinical investigation 2003;111(5):681-9.
2003: van Westerloo D J; Maris N A; Bruno M J; van der Poll T
Caerulein induced pancreatitis.
Gut 2003;52(3):452-3; author reply 453.
2003: Lettinga K D; Weijer S; Speelman P; Prins J M; Van Der Poll T; Verbon A
Reduced interferon-gamma release in patients recovered from Legionnaires' disease.
Thorax 2003;58(1):63-7.
2003: Verbon Annelies; Meijers Joost C M; Spek C Arnold; Hack C Erik; Pribble John P; Turner Terence; Dekkers Pascale E P; Axtelle Tim; Levi Marcel; van Deventer Sander J H; Reitsma Pieter H; van der Poll Tom
Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans.
The Journal of infectious diseases 2003;187(1):55-61.
2003: Zwijnenburg Petra J G; Polfliet Machteld M J; Florquin Sandrine; van den Berg Timo K; Dijkstra Christine D; van Deventer Sander J H; Roord John J; van der Poll Tom; van Furth A Marceline
CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats.
Immunology letters 2003;85(1):1-4.
2003: Knapp Sylvia; Leemans Jaklien C; Florquin Sandrine; Branger Judith; Maris Nico A; Pater Jennie; van Rooijen Nico; van der Poll Tom
Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia.
American journal of respiratory and critical care medicine 2003;167(2):171-9.
2002: Levi Marcel; de Jonge Evert; van der Poll Tom
Therapeutic intervention in disseminated intravascular coagulation: have we made any progress in the last millennium?
Blood reviews 2002;16 Suppl 1():S29-34.
2002: Sewnath Miguel E; Van Der Poll Tom; Van Noorden Cornelis J F; Ten Kate Fiebo J W; Gouma Dirk J
Endogenous interferon gamma protects against cholestatic liver injury in mice.
Hepatology (Baltimore, Md.) 2002;36(6):1466-77.
2002: Weijer Sebastiaan; Lauw Fanny N; Branger Judith; van den Blink Bernt; van der Poll Tom
Diminished interferon-gamma production and responsiveness after endotoxin administration to healthy humans.
The Journal of infectious diseases 2002;186(12):1748-53.
2002: Verbon A; Leemans J C; Weijer S; Florquin S; Van Der Poll T
Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis.
Clinical and experimental immunology 2002;130(1):32-6.
2002: Levi M; De Jonge E; van der Poll T
Recombinant human activated protein C (Xigris).
International journal of clinical practice 2002;56(7):542-5.
2002: Lettinga Kamilla D; Florquin Sandrine; Speelman Peter; van Ketel Ruud; van der Poll Tom; Verbon Annelies
Toll-like receptor 4 is not involved in host defense against pulmonary Legionella pneumophila infection in a mouse model.
The Journal of infectious diseases 2002;186(4):570-3.
2002: Leemans Jaklien C; Vervoordeldonk Margriet J B M; Florquin Sandrine; van Kessel Kok P; van der Poll Tom
Differential role of interleukin-6 in lung inflammation induced by lipoteichoic acid and peptidoglycan from Staphylococcus aureus.
American journal of respiratory and critical care medicine 2002;165(10):1445-50.
2002: Levi Marcel; ten Cate Hugo; van der Poll Tom
Endothelium: interface between coagulation and inflammation.
Critical care medicine 2002;30(5 Suppl):S220-4.
2002: Branger Judith; van den Blink Bernt; Weijer Sebastiaan; Madwed Jeffrey; Bos Carina L; Gupta Abhya; Yong Chan-Loi; Polmar Stephen H; Olszyna Dariusz P; Hack C Erik; van Deventer Sander J H; Peppelenbosch Maikel P; van der Poll Tom
Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):4070-7.
2002: Juffermans Nicole P; Weijer Sebastiaan; Verbon Annelies; Speelman Peter; van der Poll Tom
Expression of human immunodeficiency virus coreceptors CXC chemokine receptor 4 and CC chemokine receptor 5 on monocytes is down-regulated during human endotoxemia.
The Journal of infectious diseases 2002;185(7):986-9.
2002: Rijneveld Anita W; Levi Marcel; Florquin Sandrine; Speelman Peter; Carmeliet Peter; van Der Poll Tom
Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3507-11.
2002: Schultz Marc J; Rijneveld Anita W; Florquin Sandrine; Edwards Carl K; Dinarello Charles A; van der Poll Tom
Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia.
American journal of physiology. Lung cellular and molecular physiology 2002;282(2):L285-90.
2002: Sewnath Miguel E; Van Der Poll Tom; Ten Kate Fiebo J W; Van Noorden Cornelis J F; Gouma Dirk J
Interleukin-1 receptor type I gene-deficient bile duct-ligated mice are partially protected against endotoxin.
Hepatology (Baltimore, Md.) 2002;35(1):149-58.
2002: Rijneveld Anita W; van den Dobbelsteen Germie P; Florquin Sandrine; Standiford Theodore J; Speelman Peter; van Alphen Loek; van der Poll Tom
Roles of interleukin-6 and macrophage inflammatory protein-2 in pneumolysin-induced lung inflammation in mice.
The Journal of infectious diseases 2002;185(1):123-6.
2002: Rijneveld Anita W; Lauw Fanny N; Schultz Marc J; Florquin Sandrine; Te Velde Anje A; Speelman Peter; Van Deventer Sander J H; Van Der Poll Tom
The role of interferon-gamma in murine pneumococcal pneumonia.
The Journal of infectious diseases 2002;185(1):91-7.
2002: Lauw Fanny N; Branger Judith; Florquin Sandrine; Speelman Peter; van Deventer Sander J H; Akira Shizuo; van der Poll Tom
IL-18 improves the early antimicrobial host response to pneumococcal pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):372-8.
2002: Juffermans Nicole P; Leemans Jaklien C; Florquin Sandrine; Verbon Annelies; Kolk Arend H; Speelman Peter; van Deventer Sander J H; van der Poll Tom
CpG oligodeoxynucleotides enhance host defense during murine tuberculosis.
Infection and immunity 2002;70(1):147-52.
2002: Schultz Marc J; van der Poll Tom
Animal and human models for sepsis.
Annals of medicine 2002;34(7-8):573-81.
2002: Knapp Sylvia; Branger Judith; van der Poll T
Advances in research of the inflammatory response: the importance of toll-like receptors.
Wiener medizinische Wochenschrift (1946) 2002;152(21-22):552-4.
2002: Schultz Marcus J; van der Poll Tom
Modulation of pulmonary innate immunity during bacterial infection: animal studies.
Archivum immunologiae et therapiae experimentalis 2002;50(3):159-67.
2002: Juffermans Nicole P; Verbon Annelies; Van der Poll Tom
Diabetes insipidus as a complication of cryptococcal meningitis in an HIV-infected patient.
Scandinavian journal of infectious diseases 2002;34(5):397-8.
2001: Guchelaar H J; Schultz M J; van der Poll T; Koopmans R P
Pharmacokinetic-pharmacodynamic modeling of the inhibitory effect of erythromycin on tumour necrosis factor-alpha and interleukin-6 production.
Fundamental & clinical pharmacology 2001;15(6):419-24.
2001: de Jonge E; van der Poll T; Kesecioglu J; Levi M
Anticoagulant factor concentrates in disseminated intravascular coagulation: rationale for use and clinical experience.
Seminars in thrombosis and hemostasis 2001;27(6):667-74.
2001: van der Poll T; de Jonge E; Levi M
Regulatory role of cytokines in disseminated intravascular coagulation.
Seminars in thrombosis and hemostasis 2001;27(6):639-51.
2001: Levi M; de Jonge E; van der Poll T; ten Cate H
Advances in the understanding of the pathogenetic pathways of disseminated intravascular coagulation result in more insight in the clinical picture and better management strategies.
Seminars in thrombosis and hemostasis 2001;27(6):569-75.
2001: van den Blink B; Branger J; Weijer S; Deventer S H; van der Poll T; Peppelenbosch M P
Human endotoxemia activates p38 MAP kinase and p42/44 MAP kinase, but not c-Jun N-terminal kinase.
Molecular medicine (Cambridge, Mass.) 2001;7(11):755-60.
2001: Rijneveld A W; Florquin S; Branger J; Speelman P; Van Deventer S J; van der Poll T
TNF-alpha compensates for the impaired host defense of IL-1 type I receptor-deficient mice during pneumococcal pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5240-6.
2001: van der Poll T
Immunotherapy of sepsis.
The Lancet infectious diseases 2001;1(3):165-74.
2001: Olszyna D P; Vermeulen H; Baan A H; Speelman P; van Deventer S J; Gouma D J; van der Poll T
Urine interleukin-8 is a marker for urinary tract infection in postoperative patients.
Infection 2001;29(5):274-7.
2001: Polfliet M M; Zwijnenburg P J; van Furth A M; van der Poll T; Döpp E A; Renardel de Lavalette C; van Kesteren-Hendrikx E M; van Rooijen N; Dijkstra C D; van den Berg T K
Meningeal and perivascular macrophages of the central nervous system play a protective role during bacterial meningitis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4644-50.
2001: Schultz M J; Rijneveld A W; Florquin S; Speelman P; Van Deventer S J; van der Poll T
Impairment of host defence by exotoxin A in Pseudomonas aeruginosa pneumonia in mice.
Journal of medical microbiology 2001;50(9):822-7.
2001: Lauw F N; Florquin S; Speelman P; van Deventer S J; van der Poll T
Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice.
Infection and immunity 2001;69(9):5949-52.
2001: Schultz M J; Speelman P; van der Poll T
Erythromycin inhibits Pseudomonas aeruginosa-induced tumour necrosis factor-alpha production in human whole blood.
The Journal of antimicrobial chemotherapy 2001;48(2):275-8.
2001: Olszyna D P; Pajkrt D; van Deventer S J; van der Poll T
Effect of interleukin 10 on the release of the CXC chemokines growth related oncogene GRO-alpha and epithelial cell-derived neutrophil activating peptide (ENA)-78 during human endotoxemia.
Immunology letters 2001;78(1):41-4.
2001: Juffermans N P; Dekkers P E; Verbon A; Speelman P; van Deventer S J; van der Poll T
Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia.
Infection and immunity 2001;69(8):5182-5.
2001: Olszyna D P; Florquin S; Sewnath M; Branger J; Speelman P; van Deventer S J; Strieter R M; van der Poll T
CXC chemokine receptor 2 contributes to host defense in murine urinary tract infection.
The Journal of infectious diseases 2001;184(3):301-7.
2001: Levi M; de Jonge E; van der Poll T
Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation.
Critical care medicine 2001;29(7 Suppl):S90-4.
2001: Florquin S; van den Berg J G; Olszyna D P; Claessen N; Opal S M; Weening J J; van der Poll T
Release of urokinase plasminogen activator receptor during urosepsis and endotoxemia.
Kidney international 2001;59(6):2054-61.
2001: de Jonge E; Dekkers P E; Creasey A A; Hack C E; Paulson S K; Karim A; Kesecioglu J; Levi M; van Deventer S J; van der Poll T
Tissue factor pathway inhibitor does not influence inflammatory pathways during human endotoxemia.
The Journal of infectious diseases 2001;183(12):1815-8.
2001: Sewnath M E; Olszyna D P; Birjmohun R; ten Kate F J; Gouma D J; van Der Poll T
IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6323-31.
2001: Juffermans N P; Verbon A; Schultz M J; Hack C E; van Deventer S J; Speelman P; van der Poll T
Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens.
Antimicrobial agents and chemotherapy 2001;45(5):1547-9.
2001: Leemans J C; Juffermans N P; Florquin S; van Rooijen N; Vervoordeldonk M J; Verbon A; van Deventer S J; van der Poll T
Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4604-11.
2001: Olszyna D P; De Jonge E; Dekkers P E; van Deventer S J; van der Poll T
Induction of cell-associated chemokines after endotoxin administration to healthy humans.
Infection and immunity 2001;69(4):2736-8.
2001: Zwijnenburg P J; van der Poll T; Florquin S; van Deventer S J; Roord J J; van Furth A M
Experimental pneumococcal meningitis in mice: a model of intranasal infection.
The Journal of infectious diseases 2001;183(7):1143-6.
2001: Schultz M J; Rijneveld A W; Speelman P; van Deventer S J; van der Poll T
Endogenous interferon-gamma impairs bacterial clearance from lungs during Pseudomonas aeruginosa pneumonia.
European cytokine network 2001;12(1):39-44.
2001: Schultz M J; Wijnholds J; Peppelenbosch M P; Vervoordeldonk M J; Speelman P; van Deventer S J; Borst P; van der Poll T
Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):4059-64.
2001: Verbon A; Dekkers P E; ten Hove T; Hack C E; Pribble J P; Turner T; Souza S; Axtelle T; Hoek F J; van Deventer S J; van der Poll T
IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3599-605.
2001: Lauw F N; van Der Meer J T; de Metz J; Danner S A; van Der Poll T
No beneficial effect of interferon-gamma treatment in 2 human immunodeficiency virus-infected patients with Mycobacterium avium complex infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;32(4):e81-2.
2001: Juffermans N P; Speelman P; Verbon A; Veenstra J; Jie C; van Deventer S J; van Der Poll T
Patients with active tuberculosis have increased expression of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;32(4):650-2.
2001: van den Blink B; Juffermans N P; ten Hove T; Schultz M J; van Deventer S J; van der Poll T; Peppelenbosch M P
p38 mitogen-activated protein kinase inhibition increases cytokine release by macrophages in vitro and during infection in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):582-7.
2000: Boelens J J; van der Poll T; Zaat S A; Murk J L; Weening J J; Dankert J
Interleukin-1 receptor type I gene-deficient mice are less susceptible to Staphylococcus epidermidis biomaterial-associated infection than are wild-type mice.
Infection and immunity 2000;68(12):6924-31.
2000: Olszyna D P; Opal S M; Prins J M; Horn D L; Speelman P; van Deventer S J; van der Poll T
Chemotactic activity of CXC chemokines interleukin-8, growth-related oncogene-alpha, and epithelial cell-derived neutrophil-activating protein-78 in urine of patients with urosepsis.
The Journal of infectious diseases 2000;182(6):1731-7.
2000: Schultz M J; Speelman P; Zaat S A; Hack C E; van Deventer S J; van der Poll T
The effect of pseudomonas exotoxin A on cytokine production in whole blood exposed to Pseudomonas aeruginosa.
FEMS immunology and medical microbiology 2000;29(3):227-32.
2000: Juffermans N P; Paxton W A; Dekkers P E; Verbon A; de Jonge E; Speelman P; van Deventer S J; van der Poll T
Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines.
Blood 2000;96(8):2649-54.
2000: Schultz M J; Olszyna D P; de Jonge E; Verbon A; van Deventer S J; van der Poll T
Reduced ex vivo chemokine production by polymorphonuclear cells after in vivo exposure of normal humans to endotoxin.
The Journal of infectious diseases 2000;182(4):1264-7.
2000: Levi M; de Jonge E; van der Poll T; ten Cate H
Novel approaches to the management of disseminated intravascular coagulation.
Critical care medicine 2000;28(9 Suppl):S20-4.
2000: Verbon A; Juffermans N P; Speelman P; van Deventer S J; ten Berge I J; Guchelaar H J; van der Poll T
A single oral dose of thalidomide enhances the capacity of lymphocytes to secrete gamma interferon in healthy humans.
Antimicrobial agents and chemotherapy 2000;44(9):2286-90.
2000: Juffermans N P; Florquin S; Camoglio L; Verbon A; Kolk A H; Speelman P; van Deventer S J; van Der Poll T
Interleukin-1 signaling is essential for host defense during murine pulmonary tuberculosis.
The Journal of infectious diseases 2000;182(3):902-8.
2000: Juffermans N P; Dekkers P E; Peppelenbosch M P; Speelman P; van Deventer S J; van Der Poll T
Expression of the chemokine receptors CXCR1 and CXCR2 on granulocytes in human endotoxemia and tuberculosis: involvement of the p38 mitogen-activated protein kinase pathway.
The Journal of infectious diseases 2000;182(3):888-94.
2000: Lauw F N; Pajkrt D; Hack C E; Kurimoto M; van Deventer S J; van der Poll T
Proinflammatory effects of IL-10 during human endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2783-9.
2000: Juffermans N P; Verbon A; Belisle J T; Hill P J; Speelman P; van Deventer S J; van der Poll T
Mycobacterial lipoarabinomannan induces an inflammatory response in the mouse lung. A role for interleukin-1.
American journal of respiratory and critical care medicine 2000;162(2 Pt 1):486-9.
2000: Schultz M J; Speelman P; Hack C E; Buurman W A; van Deventer S J; van Der Poll T
Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniae.
The Journal of antimicrobial chemotherapy 2000;46(2):235-40.
2000: Franco R F; de Jonge E; Dekkers P E; Timmerman J J; Spek C A; van Deventer S J; van Deursen P; van Kerkhoff L; van Gemen B; ten Cate H; van der Poll T; Reitsma P H
The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation.
Blood 2000;96(2):554-9.
2000: Lauw F N; Simpson A J; Hack C E; Prins J M; Wolbink A M; van Deventer S J; Chaowagul W; White N J; van Der Poll T
Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria.
The Journal of infectious diseases 2000;182(1):206-13.
2000: Lauw F N; Simpson A J; Prins J M; van Deventer S J; Chaowagul W; White N J; van der Poll T
The CXC chemokines gamma interferon (IFN-gamma)-inducible protein 10 and monokine induced by IFN-gamma are released during severe melioidosis.
Infection and immunity 2000;68(7):3888-93.
2000: Dekkers P E; Juffermans N P; Hove T t; de Jonge E; van Deventer S J; van Der Poll T
Granulocyte colony-stimulating factor receptors on granulocytes are down-regulated after endotoxin administration to healthy humans.
The Journal of infectious diseases 2000;181(6):2067-70.
2000: Juffermans N P; Verbon A; Olszyna D P; van Deventer S J; Speelman P; van Der Poll T
Thalidomide suppresses Up-regulation of human immunodeficiency virus coreceptors CXCR4 and CCR5 on CD4+ T cells in humans.
The Journal of infectious diseases 2000;181(5):1813-6.
2000: Dekkers P E; ten Hove T; Lauw F N; Koene H R; Lumley P; van Deventer S J; van der Poll T
The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans.
Infection and immunity 2000;68(5):3036-9.
2000: Boelens J J; Dankert J; Murk J L; Weening J J; van der Poll T; Dingemans K P; Koole L; Laman J D; Zaat S A
Biomaterial-associated persistence of Staphylococcus epidermidis in pericatheter macrophages.
The Journal of infectious diseases 2000;181(4):1337-49.
2000: Dekkers P E; ten Hove T; te Velde A A; van Deventer S J; van Der Poll T
Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia.
Infection and immunity 2000;68(4):2156-60.
2000: Boelens J J; van der Poll T; Dankert J; Zaat S A
Interferon-gamma protects against biomaterial-associated Staphylococcus epidermidis infection in mice.
The Journal of infectious diseases 2000;181(3):1167-71.
2000: Dekkers P E; Juffermans N P; ten Hove T; de Jonge E; van Deventer S J; van der Poll T
Endotoxin down-regulates monocyte and granulocyte interleukin-6 receptors without influencing gp130 expression in humans.
The Journal of infectious diseases 2000;181(3):1055-61.
2000: Boelens J J; Zaat S A; Murk J L; Weening J J; van Der Poll T; Dankert J
Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1beta levels.
Infection and immunity 2000;68(3):1692-5.
2000: Lauw F N; ten Hove T; Dekkers P E; de Jonge E; van Deventer S J; van Der Poll T
Reduced Th1, but not Th2, cytokine production by lymphocytes after in vivo exposure of healthy subjects to endotoxin.
Infection and immunity 2000;68(3):1014-8.
2000: Olszyna D P; Pajkrt D; Lauw F N; van Deventer S J; van Der Poll T
Interleukin 10 inhibits the release of CC chemokines during human endotoxemia.
The Journal of infectious diseases 2000;181(2):613-20.
2000: de Jonge E; Dekkers P E; Creasey A A; Hack C E; Paulson S K; Karim A; Kesecioglu J; Levi M; van Deventer S J; van Der Poll T
Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia.
Blood 2000;95(4):1124-9.
2000: Enting R H; Foudraine N A; Lange J M; Jurriaans S; van der Poll T; Weverling G J; Portegies P
Cerebrospinal fluid beta2-microglobulin, monocyte chemotactic protein-1, and soluble tumour necrosis factor alpha receptors before and after treatment with lamivudine plus zidovudine or stavudine.
Journal of neuroimmunology 2000;102(2):216-21.
1999: Lauw F N; Simpson A J; Prins J M; Smith M D; Kurimoto M; van Deventer S J; Speelman P; Chaowagul W; White N J; van der Poll T
Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis.
The Journal of infectious diseases 1999;180(6):1878-85.
1999: Olszyna D P; Prins J M; Dekkers P E; De Jonge E; Speelman P; Van Deventer S J; Van Der Poll T
Sequential measurements of chemokines in urosepsis and experimental endotoxemia.
Journal of clinical immunology 1999;19(6):399-405.
1999: Dekkers P E; Lauw F N; ten Hove T; te Velde A A; Lumley P; Becherer D; van Deventer S J; van der Poll T
The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors during human endotoxemia.
Blood 1999;94(7):2252-8.
1999: Dekkers P E; Levi M; van Deventer S J; van der Poll T
Divergent roles of tumor necrosis factor and platelet-activating factor in endotoxin-induced release of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta in chimpanzees.
Infection and immunity 1999;67(10):5480-2.
1999: Levi M; de Jonge E; van der Poll T; ten Cate H
Disseminated intravascular coagulation.
Thrombosis and haemostasis 1999;82(2):695-705.
1999: Juffermans N P; Verbon A; van Deventer S J; van Deutekom H; Belisle J T; Ellis M E; Speelman P; van der Poll T
Elevated chemokine concentrations in sera of human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients with tuberculosis: a possible role for mycobacterial lipoarabinomannan.
Infection and immunity 1999;67(8):4295-7.
1999: Lauw F N; te Velde A A; Dekkers P E; Speelman P; Aerts J M; Hack C E; van Deventer S J; van der Poll T
Activation of mononuclear cells by interleukin-12: an in vivo study in chimpanzees.
Journal of clinical immunology 1999;19(4):231-8.
1999: van der Poll T; van Deventer S J
Cytokines and anticytokines in the pathogenesis of sepsis.
Infectious disease clinics of North America 1999;13(2):413-26, ix.
1999: Lauw F N; Dekkers P E; te Velde A A; Speelman P; Levi M; Kurimoto M; Hack C E; van Deventer S J; van der Poll T
Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees.
The Journal of infectious diseases 1999;179(3):646-52.
1999: Verbon A; Juffermans N; Van Deventer S J; Speelman P; Van Deutekom H; Van Der Poll T
Serum concentrations of cytokines in patients with active tuberculosis (TB) and after treatment.
Clinical and experimental immunology 1999;115(1):110-3.
1998: Juffermans N P; Verbon A; van Deventer S J; Buurman W A; van Deutekom H; Speelman P; van der Poll T
Serum concentrations of lipopolysaccharide activity-modulating proteins during tuberculosis.
The Journal of infectious diseases 1998;178(6):1839-42.
1998: Lemaire L C; van der Poll T; van Lanschot J J; Endert E; Buurman W A; van Deventer S J; Gouma D J
Minimally invasive surgery induces endotoxin-tolerance in the absence of detectable endotoxemia.
Journal of clinical immunology 1998;18(6):414-20.
1998: Lemaire L C; van Lanschot J J; van der Poll T; Buurman W A; van Deventer S J; Gouma D J
Lymph of patients with a systemic inflammatory response syndrome inhibits lipopolysaccharide-induced cytokine production.
The Journal of infectious diseases 1998;178(3):883-6.
1998: Olszyna D P; Prins J M; Buis B; van Deventer S J; Speelman P; van der Poll T
Levels of inhibitors of tumor necrosis factor alpha and interleukin 1beta in urine and sera of patients with urosepsis.
Infection and immunity 1998;66(8):3527-34.
1998: Schultz M J; Speelman P; Zaat S; van Deventer S J; van der Poll T
Erythromycin inhibits tumor necrosis factor alpha and interleukin 6 production induced by heat-killed Streptococcus pneumoniae in whole blood.
Antimicrobial agents and chemotherapy 1998;42(7):1605-9.
1998: Levi M; van Der POLL T; ten CATE H; Kuipers B; Biemond B J; Jansen H M; ten CATE J W
Differential effects of anti-cytokine treatment on bronchoalveolar hemostasis in endotoxemic chimpanzees.
American journal of respiratory and critical care medicine 1998;158(1):92-8.
1998: van Berge Henegouwen M I; van der Poll T; van Deventer S J; Gouma D J
Peritoneal cytokine release after elective gastrointestinal surgery and postoperative complications.
American journal of surgery 1998;175(4):311-6.
1998: Juffermans N P; Verbon A; van Deventer S J; van Deutekom H; Speelman P; van der Poll T
Tumor necrosis factor and interleukin-1 inhibitors as markers of disease activity of tuberculosis.
American journal of respiratory and critical care medicine 1998;157(4 Pt 1):1328-31.
1998: van der Poll T; van Deventer S J
The role of interleukin 6 in endotoxin-induced inflammatory responses.
Progress in clinical and biological research 1998;397():365-77.
1997: Pajkrt D; Manten A; van der Poll T; Tiel-van Buul M M; Jansen J; Wouter ten Cate J; van Deventer S J
Modulation of cytokine release and neutrophil function by granulocyte colony-stimulating factor during endotoxemia in humans.
Blood 1997;90(4):1415-24.
1997: ten Cate J W; van der Poll T; Levi M; ten Cate H; van Deventer S J
Cytokines: triggers of clinical thrombotic disease.
Thrombosis and haemostasis 1997;78(1):415-9.
1997: Pajkrt D; van der Poll T; Levi M; Cutler D L; Affrime M B; van den Ende A; ten Cate J W; van Deventer S J
Interleukin-10 inhibits activation of coagulation and fibrinolysis during human endotoxemia.
Blood 1997;89(8):2701-5.
1997: Pajkrt D; Camoglio L; Tiel-van Buul M C; de Bruin K; Cutler D L; Affrime M B; Rikken G; van der Poll T; ten Cate J W; van Deventer S J
Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: effect of timing of recombinant human IL-10 administration.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3971-7.
1997: Pajkrt D; Lerch P G; van der Poll T; Levi M; Illi M; Doran J E; Arnet B; van den Ende A; ten Cate J W; van Deventer S J
Differential effects of reconstituted high-density lipoprotein on coagulation, fibrinolysis and platelet activation during human endotoxemia.
Thrombosis and haemostasis 1997;77(2):303-7.
1997: Levi M; van der Poll T; ten Cate H; van Deventer S J
The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia.
European journal of clinical investigation 1997;27(1):3-9.
1996: Stouthard J M; Levi M; Hack C E; Veenhof C H; Romijn H A; Sauerwein H P; van der Poll T
Interleukin-6 stimulates coagulation, not fibrinolysis, in humans.
Thrombosis and haemostasis 1996;76(5):738-42.
1996: Pajkrt D; Doran J E; Koster F; Lerch P G; Arnet B; van der Poll T; ten Cate J W; van Deventer S J
Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia.
The Journal of experimental medicine 1996;184(5):1601-8.
1996: von der Möhlen M A; van der Poll T; Jansen J; Levi M; van Deventer S J
Release of bactericidal/permeability-increasing protein in experimental endotoxemia and clinical sepsis. Role of tumor necrosis factor.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4969-73.
1996: van der Poll T; Jansen J; Levi M; ten Cate H; Hack C E; Aarden L A; ten Cate J W; van Deventer S J
Interleukin 10 release during endotoxaemia in chimpanzees: role of platelet-activating factor and interleukin 6.
Scandinavian journal of immunology 1996;43(1):122-5.
1995: Godfried M H; Romijn J A; van der Poll T; Weverling G J; Corssmit E P; Endert E; Eeftinck Schattenkerk J K; Sauerwein H P
Soluble receptors for tumor necrosis factor are markers for clinical course but not for major metabolic changes in human immunodeficiency virus infection.
Metabolism: clinical and experimental 1995;44(12):1564-9.
1995: Godfried M H; van der Poll T; Mulder J W; Weverling G J; Endert E; Lange J M; Sauerwein H P
Soluble tumor necrosis factor receptors as surrogate markers for the assessment of zidovudine treatment in asymptomatic HIV-1 infection.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1995;10(5):531-9.
1995: van der Poll T; Zijlstra E E; Mevissen M
Interleukin 6 during active visceral leishmaniasis and after treatment.
Clinical immunology and immunopathology 1995;77(1):111-4.
1995: Stouthard J M; Romijn J A; Van der Poll T; Endert E; Klein S; Bakker P J; Veenhof C H; Sauerwein H P
Endocrinologic and metabolic effects of interleukin-6 in humans.
The American journal of physiology 1995;268(5 Pt 1):E813-9.
1995: Biemond B J; Levi M; Ten Cate H; Van der Poll T; Büller H R; Hack C E; Ten Cate J W
Plasminogen activator and plasminogen activator inhibitor I release during experimental endotoxaemia in chimpanzees: effect of interventions in the cytokine and coagulation cascades.
Clinical science (London, England : 1979) 1995;88(5):587-94.
1995: van der Poll T; Levi M; ten Cate H; Jansen J; Biemond B J; Haagmans B L; Eerenberg A; van Deventer S J; Hack C E; ten Cate J W
Effect of postponed treatment with an anti-tumour necrosis factor (TNF) F(ab')2 fragment on endotoxin-induced cytokine and neutrophil responses in chimpanzees.
Clinical and experimental immunology 1995;100(1):21-5.
1995: Zijlstra E E; van der Poll T; Mevissen M
Soluble receptors for tumor necrosis factor as markers of disease activity in visceral leishmaniasis.
The Journal of infectious diseases 1995;171(2):498-501.
1995: Biemond B J; Levi M; ten Cate H; Soule H R; Morris L D; Foster D L; Bogowitz C A; van der Poll T; Büller H R; ten Cate J W
Complete inhibition of endotoxin-induced coagulation activation in chimpanzees with a monoclonal Fab fragment against factor VII/VIIa.
Thrombosis and haemostasis 1995;73(2):223-30.
1995: Jansen J; van der Poll T; Levi M; ten Cate H; Gallati H; ten Cate J W; van Deventer S J
Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-alpha antibody.
Journal of clinical immunology 1995;15(1):45-50.
1994: van der Poll T; Jansen J; Levi M; ten Cate H; ten Cate J W; van Deventer S J
Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees.
The Journal of experimental medicine 1994;180(5):1985-8.
1994: Stouthard J M; van der Poll T; Endert E; Bakker P J; Veenhof C H; Sauerwein H P; Romijn J A
Effects of acute and chronic interleukin-6 administration on thyroid hormone metabolism in humans.
The Journal of clinical endocrinology and metabolism 1994;79(5):1342-6.
1994: Koopmans R; Hoek F J; van Deventer S J; van der Poll T
Model for whole body production of tumour necrosis factor-alpha in experimental endotoxaemia in healthy subjects.
Clinical science (London, England : 1979) 1994;87(4):459-65.
1994: ten Cate H; Schenk B E; Biemond B J; Levi M; van der Poll T; Buller H R; ten Cate J W
A review of studies of the activation of the blood coagulation mechanism in chimpanzees (Pan troglodytes).
Journal of medical primatology 1994;23(5):280-4.
1994: van der Poll T; Jansen J; Endert E; Sauerwein H P; van Deventer S J
Noradrenaline inhibits lipopolysaccharide-induced tumor necrosis factor and interleukin 6 production in human whole blood.
Infection and immunity 1994;62(5):2046-50.
1994: van der Poll T; Levi M; Hack C E; ten Cate H; van Deventer S J; Eerenberg A J; de Groot E R; Jansen J; Gallati H; Büller H R
Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees.
The Journal of experimental medicine 1994;179(4):1253-9.
1994: Godfried M H; van der Poll T; Weverling G J; Mulder J W; Jansen J; van Deventer S J; Sauerwein H P
Soluble receptors for tumor necrosis factor as predictors of progression to AIDS in asymptomatic human immunodeficiency virus type 1 infection.
The Journal of infectious diseases 1994;169(4):739-45.
1994: van der Poll T; van Deventer S J; ten Cate H; Levi M; ten Cate J W
Tumor necrosis factor is involved in the appearance of interleukin-1 receptor antagonist in endotoxemia.
The Journal of infectious diseases 1994;169(3):665-7.
1994: Kuipers B; van der Poll T; Levi M; van Deventer S J; ten Cate H; Imai Y; Hack C E; ten Cate J W
Platelet-activating factor antagonist TCV-309 attenuates the induction of the cytokine network in experimental endotoxemia in chimpanzees.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2438-46.
1994: van der Poll T; Levi M; van Deventer S J; ten Cate H; Haagmans B L; Biemond B J; Büller H R; Hack C E; ten Cate J W
Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees.
Blood 1994;83(2):446-51.
1994: Levi M; ten Cate H; Bauer K A; van der Poll T; Edgington T S; Büller H R; van Deventer S J; Hack C E; ten Cate J W; Rosenberg R D
Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees.
The Journal of clinical investigation 1994;93(1):114-20.
1994: van der Poll T; Levi M; ten Cate H; van Deventer S J
The role of tumor necrosis factor in systemic inflammatory responses in primate endotoxemia.
Progress in clinical and biological research 1994;388():425-33.
1994: Jansen J; van der Poll T; van Deventer S J
Endotoxin and the release of tumor necrosis factor receptors.
Progress in clinical and biological research 1994;388():383-97.
1994: ten Cate H; Levi M; van der Poll T; Biemond B J; van Deventer S J; Buller H R; ten Cate J W
Inhibition of extrinsic coagulation activation in endotoxemia; therapeutic implications.
Progress in clinical and biological research 1994;388():215-9.
1993: Portegies P; Godfried M H; Hintzen R Q; Stam J; van der Poll T; Bakker M; van Deventer S J; van Lier R A; Goudsmit J
Low levels of specific T cell activation marker CD27 accompanied by elevated levels of markers for non-specific immune activation in the cerebrospinal fluid of patients with AIDS dementia complex.
Journal of neuroimmunology 1993;48(2):241-7.
1993: van der Poll T; Jansen J; van Leenen D; von der Möhlen M; Levi M; ten Cate H; Gallati H; ten Cate J W; van Deventer S J
Release of soluble receptors for tumor necrosis factor in clinical sepsis and experimental endotoxemia.
The Journal of infectious diseases 1993;168(4):955-60.
1993: van Leenen D; van der Poll T; Levi M; ten Cate H; van Deventer S J; Hack C E; Aarden L A; ten Cate J W
Pentoxifylline attenuates neutrophil activation in experimental endotoxemia in chimpanzees.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(4):2318-25.
1993: van der Poll T; Romijn J A; Endert E; Sauerwein H P
Effects of tumor necrosis factor on the hypothalamic-pituitary-testicular axis in healthy men.
Metabolism: clinical and experimental 1993;42(3):303-7.
1993: van Deventer S J; Hart M; van der Poll T; Hack C E; Aarden L A
Endotoxin and tumor necrosis factor-alpha-induced interleukin-8 release in humans.
The Journal of infectious diseases 1993;167(2):461-54.
1993: Godfried M H; van der Poll T; Jansen J; Romijin J A; Schattenkerk J K; Endert E; van Deventer S J; Sauerwein H P
Soluble receptors for tumour necrosis factor: a putative marker of disease progression in HIV infection.
AIDS (London, England) 1993;7(1):33-6.
1992: van der Poll T; van Deventer S J; Pasterkamp G; van Mourik J A; Büller H R; ten Cate J W
Tumor necrosis factor induces von Willebrand factor release in healthy humans.
Thrombosis and haemostasis 1992;67(6):623-6.
1992: van der Poll T; van Deventer S J; Hack C E; Wolbink G J; Aarden L A; Büller H R; ten Cate J W
Effects on leukocytes after injection of tumor necrosis factor into healthy humans.
Blood 1992;79(3):693-8.
1991: Van der Poll T; Romijn J A; Endert E; Borm J J; Büller H R; Sauerwein H P
Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans.
The American journal of physiology 1991;261(4 Pt 1):E457-65.
1991: van der Poll T; van Deventer S J; Büller H R; Sturk A; ten Cate J W
Comparison of the early dynamics of systemic prostacyclin release after administration of tumor necrosis factor and endotoxin to healthy humans.
The Journal of infectious diseases 1991;164(3):599-601.
1991: van der Poll T; Levi M; Büller H R; van Deventer S J; de Boer J P; Hack C E; ten Cate J W
Fibrinolytic response to tumor necrosis factor in healthy subjects.
The Journal of experimental medicine 1991;174(3):729-32.
1991: van der Poll T; van Deventer S J; Büller H R; Sturk A; ten Cate J W
Comparison of the early dynamics of coagulation activation after injection of endotoxin and tumor necrosis factor in healthy humans.
Progress in clinical and biological research 1991;367():55-60.
1990: van der Poll T; Romijn J A; Wiersinga W M; Sauerwein H P
Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man.
The Journal of clinical endocrinology and metabolism 1990;71(6):1567-72.
1990: van der Poll T; Büller H R; ten Cate H; Wortel C H; Bauer K A; van Deventer S J; Hack C E; Sauerwein H P; Rosenberg R D; ten Cate J W
Activation of coagulation after administration of tumor necrosis factor to normal subjects.
The New England journal of medicine 1990;322(23):1622-7.

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