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Aarnoud van der Spoel

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Publications

TOP 3
Frances M Platt; Barry Boland; Aarnoud C van der Spoel
The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction.
Richard Oko; Andrew Donald; Wei Xu; Aarnoud C van der Spoel
Fusion failure of dense-cored proacrosomal vesicles in an inducible mouse model of male infertility.
Aarnoud C van der Spoel; Richard Mott; Frances M Platt
Differential sensitivity of mouse strains to an N-alkylated imino sugar: glycosphingolipid metabolism and acrosome formation.

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All Publications

2012: Frances M Platt; Barry Boland; Aarnoud C van der Spoel
The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction.
The Journal of cell biology 2012;199(5):723-34.
2011: Richard Oko; Andrew Donald; Wei Xu; Aarnoud C van der Spoel
Fusion failure of dense-cored proacrosomal vesicles in an inducible mouse model of male infertility.
Cell and tissue research 2011;346(1):119-34.
2008: Aarnoud C van der Spoel; Richard Mott; Frances M Platt
Differential sensitivity of mouse strains to an N-alkylated imino sugar: glycosphingolipid metabolism and acrosome formation.
Pharmacogenomics 2008;9(6):717-31.
2008: Elena Elliot-Smith; Anneliese O Speak; Emyr Lloyd-Evans; David A Smith; Aarnoud C van der Spoel; Mylvaganam Jeyakumar; Terry D Butters; Raymond A Dwek; Alessandra d'Azzo; Frances M Platt
Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.
Molecular genetics and metabolism 2008;94(2):204-11.
2008: Mariona Rabionet; Aarnoud C van der Spoel; Chia-Chen Chuang; Benita von Tümpling-Radosta; Manja Litjens; Diane Bouwmeester; Christina C Hellbusch; Christian Körner; Herbert Wiegandt; Karin Gorgas; Frances M Platt; Hermann-Josef Gröne; Roger Sandhoff
Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3.
The Journal of biological chemistry 2008;283(19):13357-69.
2008: David A Priestman; Aarnoud C van der Spoel; Terry D Butters; Raymond A Dwek; Frances M Platt
N-butyldeoxynojirimycin causes weight loss as a result of appetite suppression in lean and obese mice.
Diabetes, obesity & metabolism 2008;10(2):159-66.
2007: Alexander T H Wu; Peter Sutovsky; Wei Xu; Aarnoud C van der Spoel; Frances M Platt; Richard Oko
The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport.
Developmental biology 2007;312(2):471-83.
2007: Charlotte M Walden; Roger Sandhoff; Chia-Chen Chuang; Yildiz Yildiz; Terry D Butters; Raymond A Dwek; Frances M Platt; Aarnoud C van der Spoel
Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.
The Journal of biological chemistry 2007;282(45):32655-64.
2007: Giovanni D'Angelo; Elena V Polishchuk; Giuseppe Di Tullio; Michele Santoro; Antonella Di Campli; Anna Godi; Gun West; Jacek Bielawski; Chia-Chen Chuang; Aarnoud C van der Spoel; Frances M Platt; Yusuf A Hannun; Roman S Polishchuk; Peter Mattjus; Maria Antonietta De Matteis
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.
Nature 2007;449(7158):62-7.
2007: Wilhelm Bone; Charlotte M Walden; Martin Fritsch; Ulrike Voigtmann; Eckhard Leifke; Ulrich Gottwald; Stephanie Boomkamp; Frances M Platt; Aarnoud C van der Spoel
The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study.
Reproductive biology and endocrinology : RB&E 2007;5():1.
2006: Charlotte M Walden; Terry D Butters; Raymond A Dwek; Frances M Platt; Aarnoud C van der Spoel
Long-term non-hormonal male contraception in mice using N-butyldeoxynojirimycin.
Human reproduction (Oxford, England) 2006;21(5):1309-15.
2005: Ryota Suganuma; Charlotte M Walden; Terry D Butters; Frances M Platt; Raymond A Dwek; Ryuzo Yanagimachi; Aarnoud C van der Spoel
Alkylated imino sugars, reversible male infertility-inducing agents, do not affect the genetic integrity of male mouse germ cells during short-term treatment despite induction of sperm deformities.
Biology of reproduction 2005;72(4):805-13.
2003: Mylvaganam Jeyakumar; R Thomas; E Elliot-Smith; D A Smith; Aarnoud C van der Spoel; Alessandra d'Azzo; V Hugh Perry; Terry D Butters; Raymond A Dwek; Frances M Platt
Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis.
Brain : a journal of neurology 2003;126(Pt 4):974-87.
2002: Aarnoud C van der Spoel; Mylvaganam Jeyakumar; Terry D Butters; Harry M Charlton; Harry D Moore; Raymond A Dwek; Frances M Platt
Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):17173-8.
2000: Aarnoud C van der Spoel; Erik J Bonten; Alessandra d'Azzo
Processing of lysosomal beta-galactosidase. The C-terminal precursor fragment is an essential domain of the mature enzyme.
The Journal of biological chemistry 2000;275(14):10035-40.
1998: Aarnoud C van der Spoel; Erik J Bonten; Alessandra d'Azzo
Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A.
The EMBO journal 1998;17(6):1588-97.