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Leo van der Ven

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Marja Driessen; Anne S Kienhuis; Jeroen L A Pennings; Tessa E Pronk; Marianne Roodbergen; Herman P Spaink; Evert-Jan van de Brandhof; Bob van de Water; Leo T M van der Ven
Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling.
Sanne A B Hermsen; Tessa E Pronk; Evert-Jan Van den Brandhof; Leo T M van der Ven; Aldert H Piersma
Triazole-induced gene expression changes in the zebrafish embryo.
Sanne A B Hermsen; Tessa E Pronk; Evert-Jan Van den Brandhof; Leo T M van der Ven; Aldert H Piersma
Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure.

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All Publications

2013: Marja Driessen; Anne S Kienhuis; Jeroen L A Pennings; Tessa E Pronk; Marianne Roodbergen; Herman P Spaink; Evert-Jan van de Brandhof; Bob van de Water; Leo T M van der Ven
Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling.
Archives of toxicology 2013;87(5):807-23.
2012: Sanne A B Hermsen; Tessa E Pronk; Evert-Jan Van den Brandhof; Leo T M van der Ven; Aldert H Piersma
Triazole-induced gene expression changes in the zebrafish embryo.
Reproductive toxicology (Elmsford, N.Y.) 2012;34(2):216-24.
2012: Sanne A B Hermsen; Tessa E Pronk; Evert-Jan Van den Brandhof; Leo T M van der Ven; Aldert H Piersma
Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(1):303-12.
2011: Juliette Legler; Greet Schoeters; Leo T M van der Ven; Margot van Eck van der Sluijs-van de Bor; Merete Eggesbo; Max Feinberg; Timo Hamers; Janna Koppe; Tomas Trnovec
The OBELIX project: early life exposure to endocrine disruptors and obesity.
The American journal of clinical nutrition 2011;94(6 Suppl):1933S-1938S.
2011: Hellmuth Lilienthal; Leo T M van der Ven; Patrik L Andersson; Päivi Heikkinen; Matti Viluksela
Auditory effects of developmental exposure to purity-controlled polychlorinated biphenyls (PCB52 and PCB180) in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(1):100-11.
2011: Robert Roos; Satu Sankari; Hans-Joachim Schmitz; Leo T M van der Ven; Matti Viluksela; Emma Westerholm; Patrik L Andersson; Helen Håkansson; Krister Halldin; Timo Hamers; Gerd Hamscher; Päivi Heikkinen; Merja Korkalainen; Heather A Leslie; Marjo Niittynen; Dieter Schrenk
Hepatic effects of a highly purified 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in male and female rats.
Toxicology 2011;284(1-3):42-53.
2011: Sanne A B Hermsen; Evert-Jan Van den Brandhof; Leo T M van der Ven; Aldert H Piersma
Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies.
Toxicology in vitro : an international journal published in association with BIBRA 2011;25(3):745-53.
2011: Anne S Kienhuis; Jos G M Bessems; Jeroen L A Pennings; Marja Driessen; Mirjam Luijten; Joost H M van Delft; Ad Peijnenburg; Leo T M van der Ven
Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study.
Toxicology and applied pharmacology 2011;250(2):96-107.
2009: Sicco H Brandsma; Leo T M van der Ven; Jacob de Boer; P E G Leonards
Identification of hydroxylated metabolites of hexabromocyclododecane in wildlife and 28-days exposed Wistar rats.
Environmental science & technology 2009;43(15):6058-63.
2009: Leo T M van der Ven; Ton van de Kuil; P E G Leonards; Wout Slob; Hellmuth Lilienthal; Sabina Litens; Maria Herlin; Helen Håkansson; Rocío F Cantón; Martin van den Berg; Theo J Visser; Henk Van Loveren; Joseph G Vos; Aldert H Piersma
Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats.
Toxicology letters 2009;185(1):51-62.
2009: Hellmuth Lilienthal; Leo T M van der Ven; Aldert H Piersma; Joseph G Vos
Effects of the brominated flame retardant hexabromocyclododecane (HBCD) on dopamine-dependent behavior and brainstem auditory evoked potentials in a one-generation reproduction study in Wistar rats.
Toxicology letters 2009;185(1):63-72.
2008: Rocío F Cantón; Ad Peijnenburg; Ron L A P Hoogenboom; Aldert H Piersma; Leo T M van der Ven; Martin van den Berg; Marjoke Heneweer
Subacute effects of hexabromocyclododecane (HBCD) on hepatic gene expression profiles in rats.
Toxicology and applied pharmacology 2008;231(2):267-72.
2008: Leo T M van der Ven; Ton van de Kuil; P E G Leonards; Wout Slob; Rocío F Cantón; Silke Germer; Theo J Visser; Sabina Litens; Helen Håkansson; Dieter Schrenk; Martin van den Berg; Aldert H Piersma; Joseph G Vos; Antoon Opperhuizen
A 28-day oral dose toxicity study in Wistar rats enhanced to detect endocrine effects of decabromodiphenyl ether (decaBDE).
Toxicology letters 2008;179(1):6-14.
2008: Hellmuth Lilienthal; Cynthia M Verwer; Leo T M van der Ven; Aldert H Piersma; Joseph G Vos
Exposure to tetrabromobisphenol A (TBBPA) in Wistar rats: neurobehavioral effects in offspring from a one-generation reproduction study.
Toxicology 2008;246(1):45-54.
2008: Leo T M van der Ven; Ton van de Kuil; Aart Verhoef; Cynthia M Verwer; Hellmuth Lilienthal; P E G Leonards; Ute M D Schauer; Rocío F Cantón; Sabina Litens; Frank de Jong; Theo J Visser; Wolfgang Dekant; Natalia Stern; Helen Håkansson; Wout Slob; Martin van den Berg; Joseph G Vos; Aldert H Piersma
Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study.
Toxicology 2008;245(1-2):76-89.
2008: Leo T M van der Ven; Ton van de Kuil; Aart Verhoef; P E G Leonards; Wout Slob; Rocío F Cantón; Silke Germer; Timo Hamers; Theo J Visser; Sabina Litens; Helen Håkansson; Yvonne Fery; Dieter Schrenk; Martin van den Berg; Aldert H Piersma; Joseph G Vos
A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats.
Toxicology 2008;245(1-2):109-22.
2007: Isabel Morgado; Timo Hamers; Leo T M van der Ven; Deborah M Power
Disruption of thyroid hormone binding to sea bream recombinant transthyretin by ioxinyl and polybrominated diphenyl ethers.
Chemosphere 2007;69(1):155-63.
2007: Cynthia M Verwer; Leo T M van der Ven; Ruud van den Bos; Coenraad F M Hendriksen
Effects of housing condition on experimental outcome in a reproduction toxicity study.
Regulatory toxicology and pharmacology : RTP 2007;48(2):184-93.
2007: Leo T M van der Ven; Evert-Jan Van den Brandhof; José H Vos; Piet W Wester
Effects of the estrogen agonist 17beta-estradiol and antagonist tamoxifen in a partial life-cycle assay with zebrafish (Danio rerio).
Environmental toxicology and chemistry / SETAC 2007;26(1):92-9.
2007: Raoul V Kuiper; Evert-Jan Van den Brandhof; P E G Leonards; Leo T M van der Ven; Piet W Wester; Joseph G Vos
Toxicity of tetrabromobisphenol A (TBBPA) in zebrafish (Danio rerio) in a partial life-cycle test.
Archives of toxicology 2007;81(1):1-9.
2006: Leo T M van der Ven; Aart Verhoef; Ton van de Kuil; Wout Slob; P E G Leonards; Theo J Visser; Timo Hamers; Maria Herlin; Helen Håkansson; Hanna Olausson; Aldert H Piersma; Joseph G Vos
A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(2):281-92.
2006: Silke Germer; Aldert H Piersma; Leo T M van der Ven; Andreas Kamyschnikow; Yvonne Fery; Hans-Joachim Schmitz; Dieter Schrenk
Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P450 levels in rats.
Toxicology 2006;218(2-3):229-36.
2006: Leo T M van der Ven; Evert-Jan Van den Brandhof; José H Vos; Deborah M Power; Piet W Wester
Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish.
Environmental science & technology 2006;40(1):74-81.
2004: Jon P Nash; David E Kime; Leo T M van der Ven; Piet W Wester; François Brion; Gerd Maack; Petra Stahlschmidt-Allner; Charles R Tyler
Long-term exposure to environmental concentrations of the pharmaceutical ethynylestradiol causes reproductive failure in fish.
Environmental health perspectives 2004;112(17):1725-33.
2004: Piet W Wester; Leo T M van der Ven; Joseph G Vos
Comparative toxicological pathology in mammals and fish: some examples with endocrine disrupters.
Toxicology 2004;205(1-2):27-32.
2003: Leo T M van der Ven; Henrik Holbech; Martina Fenske; Evert-Jan Van den Brandhof; Francijntje K Gielis-Proper; Piet W Wester
Vitellogenin expression in zebrafish Danio rerio: evaluation by histochemistry, immunohistochemistry, and in situ mRNA hybridisation.
Aquatic toxicology (Amsterdam, Netherlands) 2003;65(1):1-11.
2003: Leo T M van der Ven; Piet W Wester; Joseph G Vos
Histopathology as a tool for the evaluation of endocrine disruption in zebrafish (Danio rerio).
Environmental toxicology and chemistry / SETAC 2003;22(4):908-13.
2002: Tina H Rasmussen; Thomas K Andreassen; Søren N Pedersen; Leo T M van der Ven; Poul Bjerregaard; Bodil Korsgaard
Effects of waterborne exposure of octylphenol and oestrogen on pregnant viviparous eelpout (Zoarces viviparus) and her embryos in ovario.
The Journal of experimental biology 2002;205(Pt 24):3857-76.
2002: P W Wester; G C M Grinwis; Leo T M van der Ven; A Dick Vethaak; J G Vos
Aquatic toxicology: opportunities for enhancement through histopathology.
Environmental toxicology and pharmacology 2002;11(3-4):289-95.
2002: Kris Van den Belt; Piet W Wester; Leo T M van der Ven; Rudi Verheyen; Hilda Witters
Effects of ethynylestradiol on the reproductive physiology in zebrafish (Danio rerio): time dependency and reversibility.
Environmental toxicology and chemistry / SETAC 2002;21(4):767-75.
1999: Leo T M van der Ven; Germie van den Dobbelsteen; B Nagarajah; Harry van Dijken; PM Dortant; Joseph G Vos; Paul Roholl
A new rat model of otitis media caused by Streptococcus pneumoniae: conditions and application in immunization protocols.
Infection and immunity 1999;67(11):6098-103.
1997: Leo T M van der Ven; Paul Roholl; M G Reijnen-Gresnigt; Ruud J Bloemen; Sylvia C van Buul-Offers
Expression of insulin-like growth factor II (IGF-II) and histological changes in the thymus and spleen of transgenic mice overexpressing IGF-II.
Histochemistry and cell biology 1997;107(3):193-203.
1997: Leo T M van der Ven; Paul Roholl; T Gloudemans; Sylvia C van Buul-Offers; M J Welters; BA Bladergroen; J A J Faber; John S Sussenbach; Willem Den Otter
Expression of insulin-like growth factors (IGFs), their receptors and IGF binding protein-3 in normal, benign and malignant smooth muscle tissues.
British journal of cancer 1997;75(11):1631-40.
1997: Leo T M van der Ven; Sylvia C van Buul-Offers; T Gloudemans; Paul Roholl; John S Sussenbach; Willem Den Otter
Histamine-stimulated expression of insulin-like growth factors in human glioma cells.
British journal of cancer 1997;75(8):1091-7.
1996: Leo T M van der Ven; Sylvia C van Buul-Offers; T Gloudemans; R J Bloemen; Paul Roholl; John S Sussenbach; Willem Den Otter
Modulation of insulin-like growth factor (IGF) action by IGF-binding proteins in normal, benign, and malignant smooth muscle tissues.
The Journal of clinical endocrinology and metabolism 1996;81(10):3629-35.
1995: Willem Den Otter; FW Hill; Wim R Klein; Linda A Everse; E J Ruitenberg; Leo T M van der Ven; Jan-Willem Koten; Peter A Steerenberg; J A J Faber; V P M G Rutten
Ocular squamous cell carcinoma in Simmental cattle in Zimbabwe.
American journal of veterinary research 1995;56(11):1440-4.
1994: Leo T M van der Ven; T Gloudemans; Paul Roholl; Sylvia C van Buul-Offers; BA Bladergroen; M J Welters; John S Sussenbach; Willem Den Otter
Growth advantage of human leiomyoma cells compared to normal smooth-muscle cells due to enhanced sensitivity toward insulin-like growth factor I.
International journal of cancer. Journal international du cancer 1994;59(3):427-34.
1993: T Gloudemans; I Pospiech; Leo T M van der Ven; Cornelis J M Lips; Willem Den Otter; John S Sussenbach
An avaII restriction fragment length polymorphism in the insulin-like growth factor II gene and the occurrence of smooth muscle tumors.
Cancer research 1993;53(23):5754-8.
1993: Leo T M van der Ven; I M Prinsen; G H Jansen; Paul Roholl; R Defferrari; R Slater; Willem Den Otter
Growth of cultured human glioma tumour cells can be regulated with histamine and histamine antagonists.
British journal of cancer 1993;68(3):475-83.
1992: T Gloudemans; I Pospiech; Leo T M van der Ven; Cornelis J M Lips; H Schneid; Willem Den Otter; John S Sussenbach
Expression and CpG methylation of the insulin-like growth factor II gene in human smooth muscle tumors.
Cancer research 1992;52(23):6516-21.