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Theo van Dinther

Research Profile

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TOP 3
G M T Vogel; Dirk G Meuleman; Theo van Dinther; Rogier C Buijsman; A W M Princen; Martine J Smit
Antithrombotic properties of a direct thrombin inhibitor with a prolonged half-life and AT-mediated factor Xa inhibitory activity.
Francis Paolucci; Helma Frasa; Frank Van Aarle; Anna Capdevla; Marie-Christine Clavies; Theo van Dinther; François Donat; Yvonne Hendriks; Michiel van den Heuvel; Teresa Nadal; Fabrice Lagrange; José Necciari; Yolanda Perez
Two sensitive and rapid chromogenic assays of fondaparinux sodium (Arixtra) in human plasma and other biological matrices.
Anton E P Adang; Adrianus P A de Man; Gerard M T Vogel; Peter D J Grootenhuis; Martine J Smit; Co A M Peters; Arie Visser; Jos B M Rewinkel; Theo van Dinther; Hans Lucas; Jan Kelder; Sjoerd van Aelst; Dick G Meuleman; Constant van Boeckel
Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics.

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All Publications

2003: G M T Vogel; Dirk G Meuleman; Theo van Dinther; Rogier C Buijsman; A W M Princen; Martine J Smit
Antithrombotic properties of a direct thrombin inhibitor with a prolonged half-life and AT-mediated factor Xa inhibitory activity.
Journal of thrombosis and haemostasis : JTH 2003;1(9):1945-54.
2003: Francis Paolucci; Helma Frasa; Frank Van Aarle; Anna Capdevla; Marie-Christine Clavies; Theo van Dinther; François Donat; Yvonne Hendriks; Michiel van den Heuvel; Teresa Nadal; Fabrice Lagrange; José Necciari; Yolanda Perez
Two sensitive and rapid chromogenic assays of fondaparinux sodium (Arixtra) in human plasma and other biological matrices.
Clinical laboratory 2003;49(9-10):451-60.
2002: Anton E P Adang; Adrianus P A de Man; Gerard M T Vogel; Peter D J Grootenhuis; Martine J Smit; Co A M Peters; Arie Visser; Jos B M Rewinkel; Theo van Dinther; Hans Lucas; Jan Kelder; Sjoerd van Aelst; Dick G Meuleman; Constant van Boeckel
Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics.
Journal of medicinal chemistry 2002;45(20):4419-32.
2000: G M T Vogel; RG van Amsterdam; Theo van Dinther; M Tromp; Dirk G Meuleman
Pre-clinical pharmacological profile of the novel glycoconjugate Org 36764 with both factor Xa and thrombin (IIa) inhibitory activities.
Thrombosis and haemostasis 2000;84(4):611-20.
1999: Jos B M Rewinkel; Hans Lucas; Martine J Smit; A B Noach; Theo van Dinther; A M Rood; A J Jenneboer; Constant van Boeckel
Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(19):2837-42.
1999: Rogier C Buijsman; JE Basten; Theo van Dinther; Gijsbert A van der Marel; Constant van Boeckel; Jacques H van Boom
Design and synthesis of a novel synthetic NAPAP-penta-saccharide conjugate displaying a dual antithrombotic action.
Bioorganic & medicinal chemistry letters 1999;9(14):2013-8.
1999: Jos B M Rewinkel; Hans Lucas; P J van Galen; A B Noach; Theo van Dinther; A M Rood; A J Jenneboer; Constant van Boeckel
1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(5):685-90.
1998: CM Dreef-Tromp; JE Basten; M A Broekhoven; Theo van Dinther; Maurice Petitou; Constant van Boeckel
Biological properties of synthetic glycoconjugate mimics of heparin comprising different molecular spacers.
Bioorganic & medicinal chemistry letters 1998;8(16):2081-6.
1994: P Westerduin; Constant van Boeckel; JE Basten; M A Broekhoven; Hans Lucas; A Rood; H van der Heijden; R G van Amsterdam; Theo van Dinther; Dirk G Meuleman
Feasible synthesis and biological properties of six 'non-glycosamino' glycan analogues of the antithrombin III binding heparin pentasaccharide.
Bioorganic & medicinal chemistry 1994;2(11):1267-80.
1993: J C Stiekema; J M Van Griensven; Theo van Dinther; Adam Cohen
A cross-over comparison of the anti-clotting effects of three low molecular weight heparins and glycosaminoglycuronan.
British journal of clinical pharmacology 1993;36(1):51-6.
1991: A de Boer; J C Stiekema; Meindert Danhof; Theo van Dinther; J K Boeijinga; Adam Cohen; Douwe D Breimer
Studies of interaction of a low-molecular-weight heparinoid (Org 10172) with cloxacillin and ticarcillin in healthy male volunteers.
Antimicrobial agents and chemotherapy 1991;35(10):2110-5.
1991: J C Stiekema; H P Wijnand; H ten Cate; J W ten Cate; J Harenberg; J F Egberts; Theo van Dinther
Partial in vivo neutralisation of plasma anticoagulant effects of Lomoparan (Org 10172) by protamine chloride.
Thrombosis research 1991;63(1):157-67.
1991: Dirk G Meuleman; P M Hobbelen; Theo van Dinther; G M Vogel; Constant van Boeckel; H C Moelker
Antifactor Xa activity and antithrombotic activity in rats of structural analogues of the minimum antithrombin III binding sequence: discovery of compounds with a longer duration of action than of the natural pentasaccharide.
Seminars in thrombosis and hemostasis 1991;17 Suppl 1():112-7.
1990: P M Hobbelen; Theo van Dinther; G M Vogel; Constant van Boeckel; H C Moelker; Dirk G Meuleman
Pharmacological profile of the chemically synthesized antithrombin III binding fragment of heparin (pentasaccharide) in rats.
Thrombosis and haemostasis 1990;63(2):265-70.
1990: J C Stiekema; A de Boer; Meindert Danhof; C Kroon; A W Broekmans; Theo van Dinther; J Voerman; Douwe D Breimer
Interaction of the combined medication with the new low-molecular-weight heparinoid Lomoparan (Org 10172) and acenocoumarol.
Haemostasis 1990;20(3):136-46.
1989: J C Stiekema; H P Wijnand; Theo van Dinther; H C Moelker; J Dawes; A Vinchenzo; H Toeberich
Safety and pharmacokinetics of the low molecular weight heparinoid Org 10172 administered to healthy elderly volunteers.
British journal of clinical pharmacology 1989;27(1):39-48.
1987: I D Bradbrook; H N Magnani; H C Moelker; P J Morrison; J Robinson; H J Rogers; R G Spector; Theo van Dinther; H Wijnand
ORG 10172: a low molecular weight heparinoid anticoagulant with a long half-life in man.
British journal of clinical pharmacology 1987;23(6):667-75.