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Willem van Eden

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Nguyen Thi Kim Anh; Koets Ad P; Santema Wiebren J; van Eden Willem; Rutten Victor P M G; Van Rhijn Ildiko
The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle.
Looringh van Beeck Frank A; Reinink Peter; Hermsen Roel; Zajonc Dirk M; Laven Marielle J; Fun Axel; Troskie Milana; Schoemaker Nico J; Morar Darshana; Lenstra Johannes A; Vervelde Lonneke; Rutten Victor P M G; van Eden Willem; Van Rhijn Ildiko
Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant and guinea pig, but not in ruminants.
Wieten Lotte; Berlo Suzanne E; Ten Brink Corlinda B; van Kooten Peter J; Singh Mahavir; van der Zee Ruurd; Glant Tibor T; Broere Femke; van Eden Willem
IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis.

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2009: Nguyen Thi Kim Anh; Koets Ad P; Santema Wiebren J; van Eden Willem; Rutten Victor P M G; Van Rhijn Ildiko
The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle.
Vaccine 2009;27(35):4818-25.
2009: Looringh van Beeck Frank A; Reinink Peter; Hermsen Roel; Zajonc Dirk M; Laven Marielle J; Fun Axel; Troskie Milana; Schoemaker Nico J; Morar Darshana; Lenstra Johannes A; Vervelde Lonneke; Rutten Victor P M G; van Eden Willem; Van Rhijn Ildiko
Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant and guinea pig, but not in ruminants.
Molecular immunology 2009;46(7):1424-31.
2009: Wieten Lotte; Berlo Suzanne E; Ten Brink Corlinda B; van Kooten Peter J; Singh Mahavir; van der Zee Ruurd; Glant Tibor T; Broere Femke; van Eden Willem
IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis.
PloS one 2009;4(1):e4186.
2008: Guichelaar Teun; ten Brink Corlinda B; van Kooten Peter J; Berlo Suzanne E; Lafeber Floris P; Broeren Chris P; van Eden Willem; Broere Femke
Cartilage proteoglycan-specific T cells as vectors of immunomodulatory biologicals in chronic proteoglycan-induced arthritis.
Molecular immunology 2008;45(13):3526-35.
2008: Broere Femke; Wieten Lotte; Klein Koerkamp Elles I; van Roon Joel A G; Guichelaar Teun; Lafeber Floris P J G; van Eden Willem
Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):899-906.
2008: van Eden Willem
XToll, a recombinant chaperonin 10 as an anti-inflammatory immunomodulator.
Current opinion in investigational drugs (London, England : 2000) 2008;9(5):523-33.
2008: Guichelaar Teun; ten Brink Corlinda B; van Kooten Peter J; Berlo Suzanne E; Broeren Chris P; van Eden Willem; Broere Femke
Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1373-81.
2008: Nolte-'t Hoen Esther N M; Boot Elmieke P J; Wagenaar-Hilbers Josée P A; van Bilsen Jolanda H M; Arkesteijn Ger J A; Storm Gert; Everse Linda A; van Eden Willem; Wauben Marca H M
Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134.
Journal of leukocyte biology 2008;83(1):112-21.
2008: Ariaans M P; van de Haar P M; Lowenthal J W; van Eden W; Hensen E J; Vervelde L
ELISPOT and intracellular cytokine staining: novel assays for quantifying T cell responses in the chicken.
Developmental and comparative immunology 2008;32(11):1398-404.
2007: Claassen Erwin A W; van Bleek Grada M; Rychnavska Zuzana S; de Groot Raoul J; Hensen Evert J; Tijhaar Edwin J; van Eden Willem; van der Most Robbert G
Identification of a CD4 T cell epitope in the pneumonia virus of mice glycoprotein and characterization of its role in protective immunity.
Virology 2007;368(1):17-25.
2007: van Eden Willem
[Natural immunity: objective and measurable]
Tijdschrift voor diergeneeskunde 2007;132(19):767-8.
2007: Van Eden Willem; Wick George; Albani Salvatore; Cohen Irun
Stress, heat shock proteins, and autoimmunity: how immune responses to heat shock proteins are to be used for the control of chronic inflammatory diseases.
Annals of the New York Academy of Sciences 2007;1113():217-37.
2007: Wieten Lotte; Broere Femke; van der Zee Ruurd; Koerkamp Elles Klein; Wagenaar Josée; van Eden Willem
Cell stress induced HSP are targets of regulatory T cells: a role for HSP inducing compounds as anti-inflammatory immuno-modulators?
FEBS letters 2007;581(19):3716-22.
2007: van Aubel Rémon A M H; Keestra A Marijke; Krooshoop Daniëlle J E B; van Eden Willem; van Putten Jos P M
Ligand-induced differential cross-regulation of Toll-like receptors 2, 4 and 5 in intestinal epithelial cells.
Molecular immunology 2007;44(15):3702-14.
2007: Van Rhijn Ildiko; Spiering Rachel; Smits Mieke; van Blokland Marja T M; de Weger Roel; van Eden Willem; Rutten Victor P M G; Koets Ad P
Highly diverse TCR delta chain repertoire in bovine tissues due to the use of up to four D segments per delta chain.
Molecular immunology 2007;44(12):3155-61.
2007: Van Rhijn Ildiko; Rutten Victor P M G; Charleston Bryan; Smits Mieke; van Eden Willem; Koets Ad P
Massive, sustained gammadelta T cell migration from the bovine skin in vivo.
Journal of leukocyte biology 2007;81(4):968-73.
2006: Hauet-Broere F; Wieten L; Guichelaar T; Berlo S; van der Zee R; Van Eden W
Heat shock proteins induce T cell regulation of chronic inflammation.
Annals of the rheumatic diseases 2006;65 Suppl 3():iii65-8.
2006: Berlo Suzanne E; Guichelaar Teun; Ten Brink Corlinda B; van Kooten Peter J; Hauet-Broeren Femke; Ludanyi Katalin; van Eden Willem; Broeren Chris P; Glant Tibor T
Increased arthritis susceptibility in cartilage proteoglycan-specific T cell receptor-transgenic mice.
Arthritis and rheumatism 2006;54(8):2423-33.
2006: van Eden Willem
Immunoregulation of autoimmune diseases.
Human immunology 2006;67(6):446-53.
2006: Guarner Francisco; Bourdet-Sicard Raphaëlle; Brandtzaeg Per; Gill Harsharnjit S; McGuirk Peter; van Eden Willem; Versalovic James; Weinstock Joel V; Rook Graham A W
Mechanisms of disease: the hygiene hypothesis revisited.
Nature clinical practice. Gastroenterology & hepatology 2006;3(5):275-84.
2006: Van Rhijn Ildiko; Koets Ad P; Im Jin Seon; Piebes Diewertje; Reddington Faye; Besra Gurdyal S; Porcelli Steven A; van Eden Willem; Rutten Victor P M G
The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4888-93.
2005: Berlo Suzanne E; van Kooten Peter J; Ten Brink Corlinda B; Hauet-Broere Femke; Oosterwegel Mariëtte A; Glant Tibor T; Van Eden W; Broeren Chris P
Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis upon in vivo activation.
Journal of autoimmunity 2005;25(3):172-80.
2005: van Eden Willem; Hauet-Broere Femke; Berlo Suzanne; Paul Liesbeth; van der Zee Ruurd; de Kleer Isme; Prakken Berent; Taams Leonie
Stress proteins as inducers and targets of regulatory T cells in arthritis.
International reviews of immunology 2005;24(3-4):181-97.
2005: van Eden Willem
[Life in a clean environment: risky if we have to believe the 'hygiene hypothesis']
Tijdschrift voor diergeneeskunde 2005;130(7):209-13.
2005: van Eden Willem; van der Zee Ruurd; Prakken Berent
Heat-shock proteins induce T-cell regulation of chronic inflammation.
Nature reviews. Immunology 2005;5(4):318-30.
2005: Langelaar M F M; Hope J C; Rutten V P M G; Noordhuizen J P T M; van Eden W; Koets A P
Mycobacterium avium ssp. paratuberculosis recombinant heat shock protein 70 interaction with different bovine antigen-presenting cells.
Scandinavian journal of immunology 2005;61(3):242-50.
2005: Boot Elmieke P J; Koning Gerben A; Storm Gert; Wagenaar-Hilbers Josée P A; van Eden Willem; Everse Linda A; Wauben Marca H M
CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis.
Arthritis research & therapy 2005;7(3):R604-15.
2004: Nolte-'t Hoen Esther N M; Amoroso Maria Grazia; Veenstra Jetty; Grosfeld-Stulemeyer Mayken C; van Eden Willem; Broeren Chris P M; Wauben Marca H M
Effector and regulatory T cells derived from the same T cell clone differ in MHC class II-peptide multimer binding.
European journal of immunology 2004;34(12):3359-69.
2004: Nolte-'t Hoen Esther N M; Wagenaar-Hilbers Josée P A; Peters Peter J; Gadella Bart M; van Eden Willem; Wauben Marca H M
Uptake of membrane molecules from T cells endows antigen-presenting cells with novel functional properties.
European journal of immunology 2004;34(11):3115-25.
2004: Nolte-'t Hoen Esther N M; Wagenaar-Hilbers Josée P A; Boot Elmieke P J; Lin Chia-Huey; Arkesteijn Ger J A; van Eden Willem; Taams Leonie S; Wauben Marca H M
Identification of a CD4+CD25+ T cell subset committed in vivo to suppress antigen-specific T cell responses without additional stimulation.
European journal of immunology 2004;34(11):3016-27.
2004: van Bilsen Jolanda H M; Wagenaar-Hilbers Josée P A; Grosfeld-Stulemeijer Mayken C J T; van der Cammen Maarten J F; van Dijk Mariska E A; van Eden Willem; Wauben Marca H M
Matrix metalloproteinases as targets for the immune system during experimental arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):5063-8.
2003: Prakken Berent J; Roord Sarah; Ronaghy Arash; Wauben Marca; Albani Salvatore; van Eden Willem
Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis.
Springer seminars in immunopathology 2003;25(1):47-63.
2003: de Kleer I M; Kamphuis S M; Rijkers G T; Scholtens L; Gordon G; De Jager W; Häfner R; van de Zee R; van Eden W; Kuis W; Prakken B J
The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10.
Arthritis and rheumatism 2003;48(7):2001-10.
2003: Van Eden Willem; Waksman Byron H
Immune regulation in adjuvant-induced arthritis: possible implications for innovative therapeutic strategies in arthritis.
Arthritis and rheumatism 2003;48(7):1788-96.
2003: van Eden Willem; Koets Ad; van Kooten Peter; Prakken Berent; van der Zee Ruurd
Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity.
Vaccine 2003;21(9-10):897-901.
2003: Ghoreschi Kamran; Thomas Peter; Breit Susanne; Dugas Martin; Mailhammer Reinhard; van Eden Willem; van der Zee Ruurd; Biedermann Tilo; Prinz Jörg; Mack Matthias; Mrowietz Ulrich; Christophers Enno; Schlöndorff Detlef; Plewig Gerd; Sander Christian A; Röcken Martin
Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease.
Nature medicine 2003;9(1):40-6.
2002: Prakken Berent; Kuis Wietse; van Eden Willem; Albani Salvatore
Heat shock proteins in juvenile idiopathic arthritis: keys for understanding remitting arthritis and candidate antigens for immune therapy.
Current rheumatology reports 2002;4(6):466-73.
2002: Cobelens Pieter M; Kavelaars Annemieke; Vroon Anne; Ringeling Marion; van der Zee Ruurd; van Eden Willem; Heijnen Cobi J
The beta 2-adrenergic agonist salbutamol potentiates oral induction of tolerance, suppressing adjuvant arthritis and antigen-specific immunity.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5028-35.
2002: Van Eden W; Van Der Zee R; Van Kooten P; Berlo S E; Cobelens P M; Kavelaars A; Heijnen C J; Prakken B; Roord S; Albani S
Balancing the immune system: Th1 and Th2.
Annals of the rheumatic diseases 2002;61 Suppl 2():ii25-8.
2002: Langelaar M; Koets A; Müller K; van Eden W; Noordhuizen J; Howard C; Hope J; Rutten V
Mycobacterium paratuberculosis heat shock protein 70 as a tool in control of paratuberculosis.
Veterinary immunology and immunopathology 2002;87(3-4):239-44.
2002: Janssen Edith M; Wauben Marca H M; Nijkamp Frans P; van Eden Willem; van Oosterhout Antoon J M
Immunomodulatory effects of antigen-pulsed macrophages in a murine model of allergic asthma.
American journal of respiratory cell and molecular biology 2002;27(2):257-64.
2002: Prakken Berent J; Roord Sarah; van Kooten Peter J S; Wagenaar Josée P A; van Eden Willem; Albani Salvatore; Wauben Marca H M
Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope.
Arthritis and rheumatism 2002;46(7):1937-46.
2002: Cobelens P M; Kavelaars A; van der Zee R; van Eden W; Heijnen C J
Dynamics of mycobacterial HSP65-induced T-cell cytokine expression during oral tolerance induction in adjuvant arthritis.
Rheumatology (Oxford, England) 2002;41(7):775-9.
2002: Koets Ad; Rutten Victor; Hoek Aad; van Mil Frans; Müller Kerstin; Bakker Douwe; Gruys Erik; van Eden Willem
Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function.
Infection and immunity 2002;70(7):3856-64.
2002: Van Bilsen Jolanda H M; Wagenaar-Hilbers Josée P A; Boot Elmieke P J; van Eden Willem; Wauben Marca H M
Searching for the cartilage-associated mimicry epitope in adjuvant arthritis.
Autoimmunity 2002;35(3):201-10.
2002: van Halteren Astrid G S; Roep Bart O; Gregori Silvia; Cooke Anne; van Eden Willem; Kraal Georg; Wauben Marca H M
Cross-reactive mycobacterial and self hsp60 epitope recognition in I-A(g7) expressing NOD, NOD-asp and Biozzi AB/H mice.
Journal of autoimmunity 2002;18(2):139-47.
2002: van Bilsen Jolanda H M; Wagenaar-Hilbers Josée P A; van der Cammen Maarten J F; van Dijk Mariska E A; van Eden Willem; Wauben Marca H M
Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration.
Arthritis research 2002;4(4):R2.
2001: Prakken B J; Wendling U; van der Zee R; Rutten V P; Kuis W; van Eden W
Induction of IL-10 and inhibition of experimental arthritis are specific features of microbial heat shock proteins that are absent for other evolutionarily conserved immunodominant proteins.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4147-53.
2001: van Eden W; Wagenaar-Hilbers J P; Wauben M H
Adjuvant arthritis in the rat.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 15():Unit 15.4.
2001: Koets A P; Rutten V P; de Boer M; Bakker D; Valentin-Weigand P; van Eden W
Differential changes in heat shock protein-, lipoarabinomannan-, and purified protein derivative-specific immunoglobulin G1 and G2 isotype responses during bovine Mycobacterium avium subsp. paratuberculosis infection.
Infection and immunity 2001;69(3):1492-8.
2001: Corrigall V M; Bodman-Smith M D; Fife M S; Canas B; Myers L K; Wooley P; Soh C; Staines N A; Pappin D J; Berlo S E; van Eden W; van Der Zee R; Lanchbury J S; Panayi G S
The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1492-8.
2001: van Tienhoven E A; ten Brink C T; van Bergen J; Koning F; van Eden W; Broeren C P
Induction of antigen specific CD4+ T cell responses by invariant chain based DNA vaccines.
Vaccine 2001;19(11-12):1515-9.
2000: Cobelens P M; Heijnen C J; Nieuwenhuis E E; Kramer P P; van der Zee R; van Eden W; Kavelaars A
Treatment of adjuvant-induced arthritis by oral administration of mycobacterial Hsp65 during disease.
Arthritis and rheumatism 2000;43(12):2694-702.
2000: Paul A G; van Kooten P J; van Eden W; van der Zee R
Highly autoproliferative T cells specific for 60-kDa heat shock protein produce IL-4/IL-10 and IFN-gamma and are protective in adjuvant arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7270-7.
2000: Janssen E M; van Oosterhout A J; Nijkamp F P; van Eden W; Wauben M H
The efficacy of immunotherapy in an experimental murine model of allergic asthma is related to the strength and site of T cell activation during immunotherapy.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7207-14.
2000: Koets A P; Rutten V P; Bakker D; van der Hage M H; van Eden W
Lewis rats are not susceptible to oral infection with Mycobacterium avium subsp. paratuberculosis.
Veterinary microbiology 2000;77(3-4):487-95.
2000: van Tienhoven E A; Broeren C P; Noordzij A; Wagenaar J P; van Eden W; Wauben M H
Nasal application of a naturally processed and presented T cell epitope derived from TCR AV11 protects against adjuvant arthritis.
International immunology 2000;12(12):1715-21.
2000: van Eden W; Wendling U; Paul L; Prakken B; van Kooten P; van der Zee R
Arthritis protective regulatory potential of self-heat shock protein cross-reactive T cells.
Cell stress & chaperones 2000;5(5):452-7.
2000: van Halteren A G; Mosselman B; Roep B O; van Eden W; Cooke A; Kraal G; Wauben M H
T cell reactivity to heat shock protein 60 in diabetes-susceptible and genetically protected nonobese diabetic mice is associated with a protective cytokine profile.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5544-51.
2000: van Tienhoven E A; van Kooten P J; Veenstra J G; van der Hage M H; van Eden W; Broeren C P
Induction of experimental autoimmune arthritis by a public epitope of the T cell receptor variable alpha domain of an arthritogenic T cell clone.
European journal of immunology 2000;30(8):2164-71.
2000: van Tienhoven E A; Steenbakkers P G; Veenstra J G; van Kooten P J; van der Cammen M J; Broeren C P; van Eden W
Generation and characterization of a clonotypic antibody specific for the T cell receptor of an arthritogenic T cell clone--studies in adjuvant arthritis.
Journal of autoimmunity 2000;15(1):1-8.
2000: Paul A G; van Der Zee R; Taams L S; van Eden W
A self-hsp60 peptide acts as a partial agonist inducing expression of B7-2 on mycobacterial hsp60-specific T cells: a possible mechanism for inhibitory T cell regulation of adjuvant arthritis?
International immunology 2000;12(7):1041-50.
2000: van Rensen A J; Taams L S; Grosfeld-Stulemeyer M C; van Eden W; Crommelin D J; Wauben M H
Induction of T cell anergy by liposomes with incorporated major histocompatibility complex (MHC) II/peptide complexes.
Pharmaceutical research 2000;17(6):720-6.
2000: Taams L S; Boot E P; van Eden W; Wauben M H
'Anergic' T cells modulate the T-cell activating capacity of antigen-presenting cells.
Journal of autoimmunity 2000;14(4):335-41.
2000: Wendling U; Paul L; van der Zee R; Prakken B; Singh M; van Eden W
A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2711-7.
2000: Janssen E M; van Oosterhout A J; van Rensen A J; van Eden W; Nijkamp F P; Wauben M H
Modulation of Th2 responses by peptide analogues in a murine model of allergic asthma: amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):580-8.
1999: Koets A P; Rutten V P; Hoek A; Bakker D; van Zijderveld F; Müller K E; van Eden W
Heat-shock protein-specific T-cell responses in various stages of bovine paratuberculosis.
Veterinary immunology and immunopathology 1999;70(1-2):105-15.
1999: Janssen E M; Wauben M H; Jonker E H; Hofman G; Van Eden W; Nijkamp F P; Van Oosterhout A J
Opposite effects of immunotherapy with ovalbumin and the immunodominant T-cell epitope on airway eosinophilia and hyperresponsiveness in a murine model of allergic asthma.
American journal of respiratory cell and molecular biology 1999;21(1):21-9.
1999: Taams L S; van Eden W; Wauben M H
Antigen presentation by T cells versus professional antigen-presenting cells (APC): differential consequences for T cell activation and subsequent T cell-APC interactions.
European journal of immunology 1999;29(5):1543-50.
1999: van Rensen A J; Wauben M H; Grosfeld-Stulemeyer M C; van Eden W; Crommelin D J
Liposomes with incorporated MHC class II/peptide complexes as antigen presenting vesicles for specific T cell activation.
Pharmaceutical research 1999;16(2):198-204.
1999: Taams L S; van Eden W; Wauben M H
Dose-dependent induction of distinct anergic phenotypes: multiple levels of T cell anergy.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):1974-81.
1999: van Eden W
Immunity to heat shock proteins and arthritic disorders.
Infectious diseases in obstetrics and gynecology 1999;7(1-2):49-54.
1998: Taams L S; van Rensen A J; Poelen M C; van Els C A; Besseling A C; Wagenaar J P; van Eden W; Wauben M H
Anergic T cells actively suppress T cell responses via the antigen-presenting cell.
European journal of immunology 1998;28(9):2902-12.
1998: van Eden W; van der Zee R; Taams L S; Prakken A B; van Roon J; Wauben M H
Heat-shock protein T-cell epitopes trigger a spreading regulatory control in a diversified arthritogenic T-cell response.
Immunological reviews 1998;164():169-74.
1998: van Eden W; van der Zee R; Paul A G; Prakken B J; Wendling U; Anderton S M; Wauben M H
Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases?
Immunology today 1998;19(7):303-7.
1998: Wauben M H; Hoedemaekers A C; Graus Y M; Wagenaar J P; Van Eden W; De Baets M H
Coimmunization of MHC class II competitor peptides during experimental autoimmune myasthenia gravis induction resulted not only in a suppressed, but also in an altered immune response.
Annals of the New York Academy of Sciences 1998;841():338-41.
1998: van der Zee R; Anderton S M; Prakken A B; Liesbeth Paul A G; van Eden W
T cell responses to conserved bacterial heat-shock-protein epitopes induce resistance in experimental autoimmunity.
Seminars in immunology 1998;10(1):35-41.
1998: Prakken B; Wauben M; van Kooten P; Anderton S; van der Zee R; Kuis W; van Eden W
Nasal administration of arthritis-related T cell epitopes of heat shock protein 60 as a promising way for immunotherapy in chronic arthritis.
Biotherapy (Dordrecht, Netherlands) 1998;10(3):205-11.
1997: Bloemendal A; Van der Zee R; Rutten V P; van Kooten P J; Farine J C; van Eden W
Experimental immunization with anti-rheumatic bacterial extract OM-89 induces T cell responses to heat shock protein (hsp)60 and hsp70; modulation of peripheral immunological tolerance as its possible mode of action in the treatment of rheumatoid arthritis (RA).
Clinical and experimental immunology 1997;110(1):72-8.
1997: Wendling U; Bloemendal A; Van Der Zee R; Rutten V P; Van Kooten P J; Farine J C; Van Eden W
Antirheumatic E. coli extract OM-89 induces T cell responses to HSP60 and 70.
International journal of immunopharmacology 1997;19(9-10):565-8.
1997: Prakken A B; van Hoeij M J; Kuis W; Kavelaars A; Heynen C J; Scholtens E; de Kleer I M; Rijkers G T; van Eden W
T-cell reactivity to human HSP60 in oligo-articular juvenile chronic arthritis is associated with a favorable prognosis and the generation of regulatory cytokines in the inflamed joint.
Immunology letters 1997;57(1-3):139-42.
1997: Prakken B J; van der Zee R; Anderton S M; van Kooten P J; Kuis W; van Eden W
Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3284-9.
1996: Wauben M H; Hoedemaekers A C; Graus Y M; Wagenaar J P; van Eden W; de Baets M H
Inhibition of experimental autoimmune myasthenia gravis by major histocompatibility complex class II competitor peptides results not only in a suppressed but also in an altered immune response.
European journal of immunology 1996;26(12):2866-75.
1996: Prakken A B; van Eden W; Rijkers G T; Kuis W; Toebes E A; de Graeff-Meeder E R; van der Zee R; Zegers B J
Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis.
Arthritis and rheumatism 1996;39(11):1826-32.
1996: Van Eden W; Anderton S M; Van Der Zee R; Prakken B J; Broeren C P; Wauben M H
(Altered) self peptides and the regulation of self reactivity in the peripheral T cell pool.
Immunological reviews 1996;149():55-73.
1996: Prakken B J; van der Zee R; Anderton S M; van Kooten P; Kuis W; van Eden W
Tolerance to an arthritogenic T-cell epitope of HSP65 and the regulation of experimental arthritis.
Annals of the New York Academy of Sciences 1996;778():425-6.
1995: Broeren C P; Lucassen M A; van der Zee R; Boog C J; Kusters J G; van Eden W
Anti-T-cell receptor peptide specific T-cells and adjuvant arthritis.
Annals of the New York Academy of Sciences 1995;756():227-8.
1995: de Graeff-Meeder E R; van Eden W; Rijkers G T; Prakken B J; Kuis W; Voorhorst-Ogink M M; van der Zee R; Schuurman H J; Helders P J; Zegers B J
Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis.
The Journal of clinical investigation 1995;95(3):934-40.
1995: Anderton S M; van der Zee R; Prakken B; Noordzij A; van Eden W
Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis.
The Journal of experimental medicine 1995;181(3):943-52.
1995: de Velasco E A; Merkus D; Anderton S; Verheul A F; Lizzio E F; Van der Zee R; Van Eden W; Hoffman T; Verhoef J; Snippe H
Synthetic peptides representing T-cell epitopes act as carriers in pneumococcal polysaccharide conjugate vaccines.
Infection and immunity 1995;63(3):961-8.
1995: Broeren C P; Wauben M H; Lucassen M A; Van Meurs M; Van Kooten P J; Boog C J; Claassen E; Van Eden W
Activated rat T cells synthesize and express functional major histocompatibility class II antigens.
Immunology 1995;84(2):193-201.
1995: van Eden W; Anderton S M; van der Zee R; Prakken A B; Rijkers G T
Specific immunity as a critical factor in the control of autoimmune arthritis: the example of hsp60 as an ancillary and protective autoantigen.
Scandinavian journal of rheumatology. Supplement 1995;101():141-5.
1994: Broeren C P; Lucassen M A; van Stipdonk M J; van der Zee R; Boog C J; Kusters J G; van Eden W
CDR1 T-cell receptor beta-chain peptide induces major histocompatibility complex class II-restricted T-T cell interactions.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):5997-6001.
1994: Joosten I; Wauben M H; Holewijn M C; Reske K; Pedersen L O; Roosenboom C F; Hensen E J; van Eden W; Buus S
Direct binding of autoimmune disease related T cell epitopes to purified Lewis rat MHC class II molecules.
International immunology 1994;6(5):751-9.
1994: Wauben M H; Kozhich A; Joosten I; Schlief A; Boog C J; van Eden W
Inhibition of entire myelin basic protein-induced experimental autoimmune encephalomyelitis in Lewis rats by major histocompatibility complex class II-binding competitor peptides.
European journal of immunology 1994;24(5):1053-60.
1994: Anderton S M; van der Zee R; Noordzij A; van Eden W
Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3656-64.
1994: Wauben M H; Joosten I; Schlief A; van der Zee R; Boog C J; van Eden W
Inhibition of experimental autoimmune encephalomyelitis by MHC class II binding competitor peptides depends on the relative MHC binding affinity of the disease-inducing peptide.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):4211-20.
1993: de Graeff-Meeder E R; Rijkers G T; Voorhorst-Ogink M M; Kuis W; van der Zee R; van Eden W; Zegers B J
Antibodies to human HSP60 in patients with juvenile chronic arthritis, diabetes mellitus, and cystic fibrosis.
Pediatric research 1993;34(4):424-8.
1993: Wauben M H; Joosten I; van der Zee R; Schlief A; Boog C J; van Eden W
Inhibition of experimental autoimmune diseases by MHC-binding competitor peptides: the competitor-modulator concept.
Transplantation proceedings 1993;25(5):2844-5.
1993: Joosten I; Wauben M H; Holewijn M C; van Kooten P J; van der Zee R; Hensen E J; van Eden W; Buus S
MHC class II (RT1.Bl) binding capacity of autoimmune disease-related T-cell determinants and their sequence analogues in the Lewis rat.
Transplantation proceedings 1993;25(5):2842-3.
1993: Wauben M H; van der Zee R; Joosten I; Boog C J; van Dijk A M; Holewijn M C; Meloen R H; van Eden W
A peptide variant of an arthritis-related T cell epitope induces T cells that recognize this epitope as a synthetic peptide but not in its naturally processed form.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(12):5722-30.
1993: de Graeff-Meeder E R; van Eden W; Rijkers G T; Prakken B J; Zegers B J; Kuis W
Heat-shock proteins and juvenile chronic arthritis.
Clinical and experimental rheumatology 1993;11 Suppl 9():S25-8.
1993: Wilbrink B; Holewijn M; Bijlsma J W; van Roy J L; den Otter W; van Eden W
Suppression of human cartilage proteoglycan synthesis by rheumatoid synovial fluid mononuclear cells activated with mycobacterial 60-kd heat-shock protein.
Arthritis and rheumatism 1993;36(4):514-8.
1992: Wilbrink B; Holewijn M; Bijlsma J W; Van Roy J L; van der Zee R; Boog C J; Den Otter W; Van Eden W
Antigen-activated T cells inhibit cartilage proteoglycan synthesis independently of T-cell proliferation.
Scandinavian journal of immunology 1992;36(5):733-43.
1992: Wauben M H; Boog C J; van der Zee R; Joosten I; Schlief A; van Eden W
Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: more than blocking alone.
The Journal of experimental medicine 1992;176(3):667-77.
1992: Hogervorst E J; Wagenaar J P; Boog C J; van der Zee R; van Embden J D; van Eden W
Adjuvant arthritis and immunity to the mycobacterial 65 kDa heat shock protein.
International immunology 1992;4(7):719-27.
1992: Boog C J; de Graeff-Meeder E R; Lucassen M A; van der Zee R; Voorhorst-Ogink M M; van Kooten P J; Geuze H J; van Eden W
Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritis.
The Journal of experimental medicine 1992;175(6):1805-10.
1992: Wauben M H; Boog C J; van der Zee R; van Eden W
Towards peptide immunotherapy in rheumatoid arthritis: competitor-modulator concept.
Journal of autoimmunity 1992;5 Suppl A():205-8.
1991: Boots A M; van Lierop M J; Wauben M H; van Kooten P J; Hensen E J; van Eden W
CD4 rat x rat and mouse x rat T cell hybridomas produced by fusion of established T cell lines and clones to W/Fu (C58NT)D.
Journal of immunological methods 1991;144(1):1-10.
1991: Rijkers G T; de Graeff-Meeder E; Voorhorst-Ogink M; Zegers B J; van Eden W
[Heat-shock proteins and arthritis]
Tijdschrift voor kindergeneeskunde 1991;59(5):178-82.
1991: van Eden W
Heat-shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis.
Immunological reviews 1991;121():5-28.
1991: Hogervorst E J; Schouls L; Wagenaar J P; Boog C J; Spaan W J; van Embden J D; van Eden W
Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus.
Infection and immunity 1991;59(6):2029-35.
1991: De Graeff-Meeder E R; van der Zee R; Rijkers G T; Schuurman H J; Kuis W; Bijlsma J W; Zegers B J; van Eden W
Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis.
Lancet 1991;337(8754):1368-72.
1991: Hogervorst E J; Boog C J; Wagenaar J P; Wauben M H; Van der Zee R; Van Eden W
T cell reactivity to an epitope of the mycobacterial 65-kDa heat-shock protein (hsp 65) corresponds with arthritis susceptibility in rats and is regulated by hsp 65-specific cellular responses.
European journal of immunology 1991;21(5):1289-96.
1991: Broeren C P; Verjans G M; Van Eden W; Kusters J G; Lenstra J A; Logtenberg T
Conserved nucleotide sequences at the 5' end of T cell receptor variable genes facilitate polymerase chain reaction amplification.
European journal of immunology 1991;21(3):569-75.
1991: van Eden W; Hogervorst E J; Wauben M H; van der Zee R; Boog C J
Heat-shock proteins as antigens in autoimmunity.
Biochemical Society transactions 1991;19(1):171-5.
1990: Hogervorst E J; Agterberg M; Wagenaar J P; Adriaanse H; Boog C J; Van De Zee R; Van Embden J D; Van Eden W; Tommassen J
Efficient recognition by rat T cell clones of an epitope of mycobacterial hsp 65 inserted in Escherichia coli outer membrane protein PhoE.
European journal of immunology 1990;20(12):2763-8.
1990: de Graeff-Meeder E R; Voorhorst M; van Eden W; Schuurman H J; Huber J; Barkley D; Maini R N; Kuis W; Rijkers G T; Zegers B J
Antibodies to the mycobacterial 65-kd heat-shock protein are reactive with synovial tissue of adjuvant arthritic rats and patients with rheumatoid arthritis and osteoarthritis.
The American journal of pathology 1990;137(5):1013-7.
1990: Van Eden W
Heat-shock proteins in autoimmune arthritis: a critical contribution based on the adjuvant arthritis model.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1990;98(5):383-94.
1990: Wilbrink B; Bijlsma J W; Huber-Bruning O; Van Roy J L; Den Otter W; Van Eden W
Mycobacterial antigens stimulate rheumatoid mononuclear cells to cartilage proteoglycan depletion.
The Journal of rheumatology 1990;17(4):532-7.
1990: van Eden W
T cell regulation in autoimmune arthritis: possibilities for immunological intervention.
Immunologic research 1990;9(3):157-63.
1989: van den Broek M F; Hogervorst E J; Van Bruggen M C; Van Eden W; van der Zee R; van den Berg W B
Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein.
The Journal of experimental medicine 1989;170(2):449-66.
1989: Kaeffer B; van Kooten P; Ederveen J; van Eden W; Horzinek M C
Properties of monoclonal antibodies against Berne virus (Toroviridae).
American journal of veterinary research 1989;50(7):1131-7.
1989: Van der Zee R; Van Eden W; Meloen R H; Noordzij A; Van Embden J D
Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides.
European journal of immunology 1989;19(1):43-7.
1989: van Eden W; de Vries R R
The immunopathogenesis and immunogenetics of rheumatoid arthritis.
British journal of rheumatology 1989;28 Suppl 1():51-3; discussion 69-71.
1989: van Eden W; Hogervorst E J; Hensen E J; van der Zee R; van Embden J D; Cohen I R
A cartilage-mimicking T-cell epitope on a 65K mycobacterial heat-shock protein: adjuvant arthritis as a model for human rheumatoid arthritis.
Current topics in microbiology and immunology 1989;145():27-43.
1989: van Eden W; Hogervorst E J; van der Zee R; van Embden J D; Hensen E J; Cohen I R
The mycobacterial 65 kD heat-shock protein and autoimmune arthritis.
Rheumatology international 1989;9(3-5):187-91.
1988: van Eden W; Thole J E; van der Zee R; Noordzij A; van Embden J D; Hensen E J; Cohen I R
Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis.
Nature 1988;331(6152):171-3.
1987: van de Water C; Haagsma N; van Kooten P J; van Eden W
An enzyme-linked immunosorbent assay for the determination of chloramphenicol using a monoclonal antibody. Application to residues in swine muscle tissue.
Zeitschrift für Lebensmittel-Untersuchung und -Forschung 1987;185(3):202-7.

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