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Paul van Helden

Research Profile

Living Beings

Mycobacterium tuberculosis

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South Africa

Chemicals & Drugs

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TOP 3
Léanie Kleynhans; Paul D van Helden; Gerhard Walzl; Nasiema Allie; Nelita Du Plessis; Muazzam Jacobs; Martin Kidd; Katharina Ronacher
The contraceptive depot medroxyprogesterone acetate impairs mycobacterial control and inhibits cytokine secretion in mice infected with Mycobacterium tuberculosis.
Ralf Baumann; Chris T Bolliger; Novel N Chegou; Susanne Kaempfer; Pauline T Lukey; Nonhlanhla F Nene; Mahavir Singh; Ralf Spallek; Paul D van Helden; Hanne Veenstra; Gerhard Walzl
Serodiagnostic markers for the prediction of the outcome of intensive phase tuberculosis therapy.
Violet Chihota; Gavin Churchyard; Katherine Fielding; Alison D Grant; C L van Halsema; Paul D van Helden; Nicolaas C Gey van Pittius
Spectrum of non-tuberculous mycobacteria identified using standard biochemical testing vs. 16S sequencing.

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All Publications

2013: Léanie Kleynhans; Paul D van Helden; Gerhard Walzl; Nasiema Allie; Nelita Du Plessis; Muazzam Jacobs; Martin Kidd; Katharina Ronacher
The contraceptive depot medroxyprogesterone acetate impairs mycobacterial control and inhibits cytokine secretion in mice infected with Mycobacterium tuberculosis.
Infection and immunity 2013;81(4):1234-44.
2013: Ralf Baumann; Chris T Bolliger; Novel N Chegou; Susanne Kaempfer; Pauline T Lukey; Nonhlanhla F Nene; Mahavir Singh; Ralf Spallek; Paul D van Helden; Hanne Veenstra; Gerhard Walzl
Serodiagnostic markers for the prediction of the outcome of intensive phase tuberculosis therapy.
Tuberculosis (Edinburgh, Scotland) 2013;93(2):239-45.
2013: Violet Chihota; Gavin Churchyard; Katherine Fielding; Alison D Grant; C L van Halsema; Paul D van Helden; Nicolaas C Gey van Pittius
Spectrum of non-tuberculous mycobacteria identified using standard biochemical testing vs. 16S sequencing.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2013;17(2):267-9.
2013: M de Vos; Sebastien Gagneux; B Müller; Paul D van Helden; P A Black; S Borrell; Robin M Warren; Thomas C Victor
Putative compensatory mutations in the rpoC gene of rifampin-resistant Mycobacterium tuberculosis are associated with ongoing transmission.
Antimicrobial agents and chemotherapy 2013;57(2):827-32.
2013: Frik A Sirgel; Erik C Böttger; Marisa Klopper; Thomas C Victor; Robin M Warren; Paul D van Helden
The rationale for using rifabutin in the treatment of MDR and XDR tuberculosis outbreaks.
PloS one 2013;8(3):e59414.
2013: Jacqueline M Cliff; Nicholas Constantinou; Jang-Eun Cho; Taane G Clark; Ken Duncan; Elizabeth C King; Ji-Sook Lee; Pauline T Lukey; Katharina Ronacher; Paul D van Helden; Gerhard Walzl; Hazel M Dockrell
Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response.
The Journal of infectious diseases 2013;207(1):18-29.
2012: M Barnard; M Bosman; G Coetzee; Nicolaas C Gey van Pittius; Paul D van Helden; Robin M Warren
The diagnostic performance of the GenoType MTBDRplus version 2 line probe assay is equivalent to that of the Xpert MTB/RIF assay.
Journal of clinical microbiology 2012;50(11):3712-6.
2012: Nicolaas C Gey van Pittius; Tiny Hlokwe; Dewald F Keet; Anita L Michel; Keith D Perrett; Elizabeth M Streicher; Robin M Warren; Paul D van Helden
Infection of African buffalo (Syncerus caffer) by oryx bacillus, a rare member of the antelope clade of the Mycobacterium tuberculosis complex.
Journal of wildlife diseases 2012;48(4):849-57.
2012: Sven D C Parsons; David Cooper; Angela M Menezes; Gerhard Walzl; Robin M Warren; Paul D van Helden
Development of a diagnostic gene expression assay for tuberculosis and its use under field conditions in African buffaloes (Syncerus caffer).
Veterinary immunology and immunopathology 2012;148(3-4):337-42.
2012: Elizabeth M Streicher; Marisa Tait; Andre Trollip; Paul D van Helden; Thomas C Victor; Violet Chihota; Nicolaas C Gey van Pittius; Kim G P Hoek; Charmaine Mlambo; Borna Müller; Manormoney Pillay; Frik A Sirgel; Robin M Warren
Emergence and treatment of multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in South Africa.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2012;12(4):686-94.
2012: S D C Parsons; Robin M Warren; Nicolaas C Gey van Pittius; T H M Ottenhoff; Paul D van Helden
Detection of Mycobacterium tuberculosis infection in dogs in a high-risk setting.
Research in veterinary science 2012;92(3):414-9.
2012: Frik A Sirgel; Elizabeth M Streicher; Paul D van Helden; Thomas C Victor; Robin M Warren; Erik C Böttger
gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis.
The Journal of antimicrobial chemotherapy 2012;67(5):1088-93.
2012: E M Streicher; Paul D van Helden; Thomas C Victor; R M Anthony; I Bergval; M Bosman; E C Böttger; G Coetzee; K Dheda; N C Gey van Pittius; Robin M Warren
Mycobacterium tuberculosis population structure determines the outcome of genetics-based second-line drug resistance testing.
Antimicrobial agents and chemotherapy 2012;56(5):2420-7.
2012: Violet N Chihota; Gerrit Coetzee; Nicolaas C Gey van Pittius; Madeleine Hanekom; Cindy Hayes; Elsé Marais; Charmaine K Mlambo; Borna Müller; Manormoney Pillay; Elizabeth M Streicher; Marisa Tait; Andre Trollip; Gian D van der Spuy; Paul D van Helden; Tommie C Victor; M Bosman; Robin M Warren
Population structure of multi- and extensively drug-resistant Mycobacterium tuberculosis strains in South Africa.
Journal of clinical microbiology 2012;50(3):995-1002.
2012: Frik A Sirgel; Elizabeth M Streicher; Paul D van Helden; Thomas C Victor; Robin M Warren; Erik C Böttger
embB306 mutations as molecular indicators to predict ethambutol susceptibility in Mycobacterium tuberculosis.
Chemotherapy 2012;58(5):358-63.
2012: Nikki le Roex; Harry Noyes; Paul D van Helden; Daniel G Bradley; Andrew Brass; Suzanne Kay; Steven J Kemp; Eileen G Hoal
Novel SNP Discovery in African Buffalo, Syncerus caffer, using high-throughput Sequencing.
PloS one 2012;7(11):e48792.
2012: Novel N Chegou; Paulin N Essone; Kees L M C Franken; Stefan H E Kaufmann; Michel R Klein; Andre G Loxton; Tom H M Ottenhoff; Shreemanta K Parida; Kim Stanley; Gian D van der Spuy; Paul D van Helden; Gillian F Black; Gerhard Walzl
Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area.
PloS one 2012;7(6):e38501.
2012: A Müller; L A Adams; Eileen G Hoal; Marlo Möller; Robin M Warren; Paul D van Helden
Comparative analysis of a putative tuberculosis-susceptibility gene, MC3R, and pseudogene sequences in cattle, African buffalo, hyena, rhinoceros and other African bovids and ruminants.
Cytogenetic and genome research 2012;136(2):117-22.
2011: Isobella Honeyborne; Timothy D McHugh; Felicity M Perrin; Patrick P J Phillips; Katharina Ronacher; Paul D van Helden; Gerhard Walzl; Laura Wright; Selina Bannoo; Anna Bateson; Nora Carroll; Stephen H Gillespie
Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment.
Journal of clinical microbiology 2011;49(11):3905-11.
2011: M Hanekom; C R E McEvoy; Paul D van Helden; Thomas C Victor; Nicolaas C Gey van Pittius; Robin M Warren
Mycobacterium tuberculosis Beijing genotype: a template for success.
Tuberculosis (Edinburgh, Scotland) 2011;91(6):510-23.
2011: Kim G P Hoek; Paul D van Helden; Annelies van Rie; Robin M Warren; Thomas C Victor
Detecting drug-resistant tuberculosis: the importance of rapid testing.
Molecular diagnosis & therapy 2011;15(4):189-94.
2011: Sven D C Parsons; David Cooper; Alicia J McCall; Warren A McCall; Elizabeth M Streicher; Nicholas C le Maitre; Annélle Müller; Robin M Warren; Nicolaas C Gey van Pittius; Paul D van Helden
Modification of the QuantiFERON-TB Gold (In-Tube) assay for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).
Veterinary immunology and immunopathology 2011;142(1-2):113-8.
2011: Gail E Louw; C R E McEvoy; Megan Murray; Paul D van Helden; Nicolaas C Gey van Pittius; Melanie Grobbelaar; Rogelio Hernandez-Pando; Adelina Jimenez; Rosalba Leon; Robin M Warren; Thomas C Victor
Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux.
American journal of respiratory and critical care medicine 2011;184(2):269-76.
2011: Lindsey A Adams; Marlo Möller; Almut Nebel; Stefan Schreiber; Lize van der Merwe; Paul D van Helden; Eileen G Hoal
Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility.
European journal of human genetics : EJHG 2011;19(6):676-81.
2011: B Müller; Elizabeth M Streicher; K G P Hoek; M Tait; A Trollip; M Bosman; G J Coetzee; E M Chabula-Nxiweni; E Hoosain; Nicolaas C Gey van Pittius; Thomas C Victor; Paul D van Helden; Robin M Warren
inhA promoter mutations: a gateway to extensively drug-resistant tuberculosis in South Africa?
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2011;15(3):344-51.
2011: Erika de Wit; Lize van der Merwe; Paul D van Helden; Eileen G Hoal
Gene-gene interaction between tuberculosis candidate genes in a South African population.
Mammalian genome : official journal of the International Mammalian Genome Society 2011;22(1-2):100-10.
2011: Borna Müller; Lin-Mari de Klerk-Lorist; Marijke M Henton; Emily Lane; Sven Parsons; Antoinette Kotze; Paul D van Helden; Nicolaas C Gey van Pittius; Manfred Tanner
Mixed infections of Corynebacterium pseudotuberculosis and non-tuberculous mycobacteria in South African antelopes presenting with tuberculosis-like lesions.
Veterinary microbiology 2011;147(3-4):340-5.
2011: Léanie Kleynhans; André G Loxton; Gillian F Black; Nelita Du Plessis; Martin Kidd; Paul D van Helden; Gerhard Walzl; Katharina Ronacher
Medroxyprogesterone acetate alters Mycobacterium bovis BCG-induced cytokine production in peripheral blood mononuclear cells of contraceptive users.
PloS one 2011;6(9):e24639.
2010: Andreas H Diacon; J S Maritz; A Venter; Paul D van Helden; K Andries; D F McNeeley; Peter R Donald
Time to detection of the growth of Mycobacterium tuberculosis in MGIT 960 for determining the early bactericidal activity of antituberculosis agents.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2010;29(12):1561-5.
2010: Sven D C Parsons; CJ de Villiers; Nicolaas C Gey van Pittius; Robin M Warren; Paul D van Helden
Detection of Mycobacterium kansasii infection in a rhesus macaque (Macaca mulatta) using a modified QuantiFERON-TB Gold assay.
Veterinary immunology and immunopathology 2010;136(3-4):330-4.
2010: Kathleen A Alexander; Pete N Laver; Anita L Michel; Mark Williams; Paul D van Helden; Robin M Warren; Nicolaas C Gey van Pittius
Novel Mycobacterium tuberculosis complex pathogen, M. mungi.
Emerging infectious diseases 2010;16(8):1296-9.
2010: Erika de Wit; Wayne Delport; Chimusa E Rugamika; Ayton Meintjes; Marlo Möller; Paul D van Helden; Cathal Seoighe; Eileen G Hoal
Genome-wide analysis of the structure of the South African Coloured Population in the Western Cape.
Human genetics 2010;128(2):145-53.
2010: Ben J Marais; Paul D van Helden; Peter R Donald
Adequacy of 6-month follow-up in chemotherapy trials.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2010;14(7):927; author reply 928.
2010: Keertan Dheda; Karen Shean; Alimuddin Zumla; Motasim Badri; Elizabeth M Streicher; Liesl Page-Shipp; Paul A Willcox; Melanie-Anne John; Gary Reubenson; Darshini Govindasamy; Michelle Wong; Xavier Padanilam; Alicia Dziwiecki; Paul D van Helden; Sweetness Siwendu; Julie Jarand; Colin Nigel Menezes; Avril Burns; Thomas Victor; Robin Warren; Martin P Grobusch; Martie van der Walt; Charlotte Kvasnovsky
Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study.
Lancet 2010;375(9728):1798-807.
2010: Lluis Quintana-Murci; Christine Harmant; Hélène Quach; Oleg Balanovsky; Valery Zaporozhchenko; Connie Bormans; Paul D van Helden; Eileen G Hoal; Doron M Behar
Strong maternal Khoisan contribution to the South African coloured population: a case of gender-biased admixture.
American journal of human genetics 2010;86(4):611-20.
2010: Marlo Möller; Friederike Flachsbart; Andreas Till; Thorsten Thye; Rolf D Horstmann; Christian G Meyer; Ivy Osei; Paul D van Helden; Eileen G Hoal; Stefan Schreiber; Almut Nebel; Andre Franke
A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.
American journal of respiratory and critical care medicine 2010;181(4):388-93.
2010: Marlo Möller; Almut Nebel; Paul D van Helden; Stefan Schreiber; Eileen G Hoal
Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.
BMC infectious diseases 2010;10():154.
2010: R Johnson; Robin M Warren; Gian D van der Spuy; Nicolaas C Gey van Pittius; D Theron; Elizabeth M Streicher; M Bosman; G J Coetzee; Paul D van Helden; Thomas C Victor
Drug-resistant tuberculosis epidemic in the Western Cape driven by a virulent Beijing genotype strain.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2010;14(1):119-21.
2009: Paul D van Helden; S D C Parsons; Nicolaas C Gey van Pittius
'Emerging' mycobacteria in South Africa.
Journal of the South African Veterinary Association 2009;80(4):210-4.
2009: Sven D C Parsons; Tertius A Gous; Robin M Warren; Charon de Villiers; Jürgen V Seier; Paul D van Helden
Detection of Mycobacterium tuberculosis infection in chacma baboons (Papio ursinus) using the QuantiFERON-TB gold (in-tube) assay.
Journal of medical primatology 2009;38(6):411-7.
2009: K G P Hoek; H Simon Schaaf; Nicolaas C Gey van Pittius; Paul D van Helden; R M Warren
Resistance to pyrazinamide and ethambutol compromises MDR/XDR-TB treatment.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2009;99(11):785-7.
2009: H Simon Schaaf; Thomas C Victor; A Venter; W Brittle; Annemarie M Jordaan; Anneke C Hesseling; Ben J Marais; Paul D van Helden; Peter R Donald
Ethionamide cross- and co-resistance in children with isoniazid-resistant tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2009;13(11):1355-9.
2009: C R E McEvoy; Robin M Warren; Paul D van Helden; Nicolaas C Gey van Pittius
Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes.
Tuberculosis (Edinburgh, Scotland) 2009;89(6):439-42.
2009: Oluseye K Onajole; Karnishree Govender; PV Govender; Paul D van Helden; Hendrik G Kruger; Glenn E M Maguire; Karen Muthusamy; Manormoney Pillay; Ian Wiid; Thavendran Govender
Pentacyclo-undecane derived cyclic tetra-amines: synthesis and evaluation as potent anti-tuberculosis agents.
European journal of medicinal chemistry 2009;44(11):4297-305.
2009: Ian W Espie; Tiny M Hlokwe; Nicolaas C Gey van Pittius; Emily Lane; Adrian S W Tordiffe; Anita L Michel; Annélle Müller; Antoinette Kotze; Paul D van Helden
Pulmonary infection due to Mycobacterium bovis in a black rhinoceros (Diceros bicornis minor) in South Africa.
Journal of wildlife diseases 2009;45(4):1187-93.
2009: G E Louw; Robin M Warren; N C Gey van Pittius; C R E McEvoy; Paul D van Helden; Thomas C Victor
A balancing act: efflux/influx in mycobacterial drug resistance.
Antimicrobial agents and chemotherapy 2009;53(8):3181-9.
2009: Peter R Donald; Paul D van Helden
The global burden of tuberculosis--combating drug resistance in difficult times.
The New England journal of medicine 2009;360(23):2393-5.
2009: Robin M Warren; Elizabeth M Streicher; N C Gey van Pittius; Ben J Marais; Gian D van der Spuy; Thomas C Victor; Frik A Sirgel; Peter R Donald; Paul D van Helden
The clinical relevance of Mycobacterial pharmacogenetics.
Tuberculosis (Edinburgh, Scotland) 2009;89(3):199-202.
2009: Pieter Uys; Robin Warren; Paul D van Helden; Megan Murray; Thomas C Victor
Potential of rapid diagnosis for controlling drug-susceptible and drug-resistant tuberculosis in communities where Mycobacterium tuberculosis infections are highly prevalent.
Journal of clinical microbiology 2009;47(5):1484-90.
2009: Ben J Marais; Anneke C Hesseling; H Simon Schaaf; Robert P Gie; Paul D van Helden; Robin M Warren
Mycobacterium tuberculosis transmission is not related to household genotype in a setting of high endemicity.
Journal of clinical microbiology 2009;47(5):1338-43.
2009: Gian D van der Spuy; Paul D van Helden; Robin M Warren
Effect of study duration on the interpretation of tuberculosis molecular epidemiology investigations.
Tuberculosis (Edinburgh, Scotland) 2009;89(3):238-42.
2009: Gian D van der Spuy; Robin M Warren; Paul D van Helden
The role of molecular epidemiology in low-income, high-burden countries.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2009;13(4):419-20.
2009: Marlo Möller; Almut Nebel; Ruta Valentonyte; Paul D van Helden; Stefan Schreiber; Eileen G Hoal
Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population.
Tuberculosis (Edinburgh, Scotland) 2009;89(2):189-94.
2009: Gian D van der Spuy; K Kremer; S L Ndabambi; Nulda Beyers; R Dunbar; Ben J Marais; Paul D van Helden; Robin M Warren
Changing Mycobacterium tuberculosis population highlights clade-specific pathogenic characteristics.
Tuberculosis (Edinburgh, Scotland) 2009;89(2):120-5.
2009: Pieter W Uys; Paul D van Helden; John W Hargrove
Tuberculosis reinfection rate as a proportion of total infection rate correlates with the logarithm of the incidence rate: a mathematical model.
Journal of the Royal Society, Interface / the Royal Society 2009;6(30):11-5.
2009: Frik A Sirgel; Ian Wiid; Paul D van Helden
Measuring minimum inhibitory concentrations in mycobacteria.
Methods in molecular biology (Clifton, N.J.) 2009;465():173-86.
2009: Robin M Warren; Paul D van Helden; Nicolaas C Gey van Pittius
Insertion element IS6110-based restriction fragment length polymorphism genotyping of Mycobacterium tuberculosis.
Methods in molecular biology (Clifton, N.J.) 2009;465():353-70.
2009: C R E McEvoy; Paul D van Helden; Robin M Warren; Nicolaas C Gey van Pittius
Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region.
BMC evolutionary biology 2009;9():237.
2009: Novel N Chegou; Gillian F Black; Martin Kidd; Paul D van Helden; Gerhard Walzl
Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report.
BMC pulmonary medicine 2009;9():21.
2009: Don Hayward; Paul D van Helden; Ian Wiid
Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for Actinobacteria speciation.
BMC evolutionary biology 2009;9():48.
2008: Nora Carroll; Pieter Uys; Anneke C Hesseling; K Lawrence; Carmen Pheiffer; F Salker; K Duncan; Nulda Beyers; Paul D van Helden
Prediction of delayed treatment response in pulmonary tuberculosis: use of time to positivity values of Bactec cultures.
Tuberculosis (Edinburgh, Scotland) 2008;88(6):624-30.
2008: M Hanekom; Gian D van der Spuy; Nicolaas C Gey van Pittius; C R E McEvoy; K G P Hoek; S L Ndabambi; Annemarie M Jordaan; Thomas C Victor; Paul D van Helden; Robin M Warren
Discordance between mycobacterial interspersed repetitive-unit-variable-number tandem-repeat typing and IS6110 restriction fragment length polymorphism genotyping for analysis of Mycobacterium tuberculosis Beijing strains in a setting of high incidence of tuberculosis.
Journal of clinical microbiology 2008;46(10):3338-45.
2008: S D C Parsons; T A Gous; Robin M Warren; Paul D van Helden
Pulmonary Mycobacterium tuberculosis (Beijing strain) infection in a stray dog.
Journal of the South African Veterinary Association 2008;79(2):95-8.
2008: K G P Hoek; Nicolaas C Gey van Pittius; H Moolman-Smook; K Carelse-Tofa; Annemarie M Jordaan; Gian D van der Spuy; Elizabeth M Streicher; Thomas C Victor; Paul D van Helden; Robin M Warren
Fluorometric assay for testing rifampin susceptibility of Mycobacterium tuberculosis complex.
Journal of clinical microbiology 2008;46(4):1369-73.
2008: O J Strauss; Robin M Warren; Annemarie M Jordaan; Elizabeth M Streicher; M Hanekom; A A Falmer; H Albert; A Trollip; E Hoosain; Paul D van Helden; Thomas C Victor
Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence.
Journal of clinical microbiology 2008;46(4):1514-6.
2008: Andrea L Gibson; Richard C Huard; Nicolaas C Gey van Pittius; Luiz Claudio Oliveira Lazzarini; Jeffrey Driscoll; Natalia Kurepina; Thierry Zozio; Christophe Sola; Silvana Miranda Spindola; Afrânio L Kritski; Daniel Fitzgerald; Kristin Kremer; Helmi Mardassi; Poonam Chitale; Jessica Brinkworth; Dario Garcia de Viedma; Brigitte Gicquel; Jean W Pape; Dick Van Soolingen; Barry N Kreiswirth; Robin M Warren; Paul D van Helden; Nalin Rastogi; Philip N Suffys; Jose Lapa e Silva; John L Ho
Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family.
Journal of clinical microbiology 2008;46(4):1259-67.
2008: Rabia Johnson; Annemarie M Jordaan; Rob Warren; M Bosman; Douglas Young; Judit N Nagy; John R Wain; Paul D van Helden; Thomas C Victor
Drug susceptibility testing using molecular techniques can enhance tuberculosis diagnosis.
Journal of infection in developing countries 2008;2(1):40-5.
2008: Stephen J Millen; Pieter Uys; John Hargrove; Paul D van Helden; Brian Williams
The effect of diagnostic delays on the drop-out rate and the total delay to diagnosis of tuberculosis.
PloS one 2008;3(4):e1933.
2008: Paul D van Helden; Nicolaas C Gey van Pittius; Robin M Warren; Anita Michel; Tiny Hlokwe; Darshana Morar; Jacques Godfroid; Elizabeth C du Plessis; Roy Bengis
Pulmonary infection due to Mycobacterium goodii in a spotted hyena (Crocuta crocuta) from South Africa.
Journal of wildlife diseases 2008;44(1):151-4.
2008: Paul D van Helden; Robin M Warren; Pieter Uys
Predicting reinfection in tuberculosis.
The Journal of infectious diseases 2008;197(1):172-3; author reply 173-4.
2008: Hanne Veenstra; Ralf Baumann; Pauline T Lukey; Nulda Beyers; Paul D van Helden; Gerhard Walzl
High levels of intracellular IL-4 are expressed in circulating apoptotic T cells in patients with tuberculosis and in community controls.
Tuberculosis (Edinburgh, Scotland) 2008;88(1):21-30.
2008: Sven Parsons; Sarah G D Smith; Quinton Martins; William Horsnell; Tertius A Gous; Elizabeth M Streicher; Robin M Warren; Paul D van Helden; Nicolaas C Gey van Pittius
Pulmonary infection due to the dassie bacillus (Mycobacterium tuberculosis complex sp.) in a free-living dassie (rock hyrax-Procavia capensis) from South Africa.
Tuberculosis (Edinburgh, Scotland) 2008;88(1):80-3.
2007: William Bourn; Yvette Jansen; Helen Stutz; Robin M Warren; Anna-Lise Williamson; Paul D van Helden
Creation and characterisation of a high-copy-number version of the pAL5000 mycobacterial replicon.
Tuberculosis (Edinburgh, Scotland) 2007;87(6):481-8.
2007: C R E McEvoy; Alecia A Falmer; Nicolaas C Gey van Pittius; Thomas C Victor; Paul D van Helden; Robin M Warren
The role of IS6110 in the evolution of Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2007;87(5):393-404.
2007: Hanne Veenstra; Ilse Crous; Shweta Brahmbhatt; Pauline T Lukey; Nulda Beyers; Paul D van Helden; Gerhard Walzl
Changes in the kinetics of intracellular IFN-gamma production in TB patients during treatment.
Clinical immunology (Orlando, Fla.) 2007;124(3):336-44.
2007: A H Diacon; R F Patientia; A Venter; Paul D van Helden; Peter J Smith; Helen McIlleron; J Stefan Maritz; Peter R Donald
Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears.
Antimicrobial agents and chemotherapy 2007;51(8):2994-6.
2007: Peter R Donald; Donald P Parkin; Heine I Seifart; H Simon Schaaf; Paul D van Helden; Cedric J Werely; Frik A Sirgel; A Venter; J Stefan Maritz
The influence of dose and N-acetyltransferase-2 (NAT2) genotype and phenotype on the pharmacokinetics and pharmacodynamics of isoniazid.
European journal of clinical pharmacology 2007;63(7):633-9.
2007: M Hanekom; Gian D van der Spuy; Nicolaas C Gey van Pittius; C R E McEvoy; S L Ndabambi; Thomas C Victor; Eileen G Hoal; Paul D van Helden; Robin M Warren
Evidence that the spread of Mycobacterium tuberculosis strains with the Beijing genotype is human population dependent.
Journal of clinical microbiology 2007;45(7):2263-6.
2007: M Hanekom; Gian D van der Spuy; Elizabeth M Streicher; S L Ndabambi; C R E McEvoy; M Kidd; Nulda Beyers; Thomas C Victor; Paul D van Helden; Robin M Warren
A recently evolved sublineage of the Mycobacterium tuberculosis Beijing strain family is associated with an increased ability to spread and cause disease.
Journal of clinical microbiology 2007;45(5):1483-90.
2007: Chantal L Babb; E Hanekom Keet; Paul D van Helden; Eileen G Hoal
SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population.
Human genetics 2007;121(3-4):521-2.
2007: Marlo Möller; Ruta Kwiatkowski; Almut Nebel; Paul D van Helden; Eileen G Hoal; Stefan Schreiber
Allelic variation in BTNL2 and susceptibility to tuberculosis in a South African population.
Microbes and infection / Institut Pasteur 2007;9(4):522-8.
2007: Marlo Möller; Almut Nebel; Ruta Kwiatkowski; Paul D van Helden; Eileen G Hoal; Stefan Schreiber
Host susceptibility to tuberculosis: CARD15 polymorphisms in a South African population.
Molecular and cellular probes 2007;21(2):148-51.
2007: H S Schaaf; Thomas C Victor; Erica Engelke; W Brittle; Ben J Marais; Anneke C Hesseling; Paul D van Helden; Peter R Donald
Minimal inhibitory concentration of isoniazid in isoniazid-resistant Mycobacterium tuberculosis isolates from children.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2007;26(3):203-5.
2007: Luis B Barreiro; Olivier Neyrolles; Chantal L Babb; Paul D van Helden; Brigitte Gicquel; Eileen G Hoal; Lluis Quintana-Murci
Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility.
Human immunology 2007;68(2):106-12.
2007: Thomas C Victor; Elizabeth M Streicher; C Kewley; Annemarie M Jordaan; Gian D van der Spuy; M Bosman; H Louw; M Murray; D Young; Paul D van Helden; Robin M Warren
Spread of an emerging Mycobacterium tuberculosis drug-resistant strain in the western Cape of South Africa.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2007;11(2):195-201.
2007: Rohit Mistry; Jacqueline Cliff; Christopher L Clayton; Nulda Beyers; Yasmin S Mohamed; Paul A Wilson; Hazel M Dockrell; Don M Wallace; Paul D van Helden; Ken Duncan; Pauline T Lukey
Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis.
The Journal of infectious diseases 2007;195(3):357-65.
2007: Pieter Uys; Robin M Warren; Paul D van Helden
A threshold value for the time delay to TB diagnosis.
PloS one 2007;2(8):e757.
2007: Elizabeth M Streicher; Thomas C Victor; Gian D van der Spuy; C Sola; N Rastogi; Paul D van Helden; Robin M Warren
Spoligotype signatures in the Mycobacterium tuberculosis complex.
Journal of clinical microbiology 2007;45(1):237-40.
2006: R Johnson; Robin Warren; O J Strauss; Annemarie M Jordaan; A A Falmer; Nulda Beyers; H Simon Schaaf; M Murray; K Cloete; Paul D van Helden; Thomas C Victor
An outbreak of drug-resistant tuberculosis caused by a Beijing strain in the western Cape, South Africa.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2006;10(12):1412-4.
2006: Paul D van Helden; Peter R Donald; Thomas C Victor; H Simon Schaaf; Eileen G Hoal; Gerhard Walzl; Robin M Warren
Antimicrobial resistance in tuberculosis: an international perspective.
Expert review of anti-infective therapy 2006;4(5):759-66.
2006: Ben J Marais; Thomas C Victor; Anneke C Hesseling; Madeleine Barnard; Annemarie M Jordaan; Wendy Brittle; Helmuth Reuter; Nulda Beyers; Paul D van Helden; Robin M Warren; H Simon Schaaf
Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape Province of South Africa.
Journal of clinical microbiology 2006;44(10):3539-43.
2006: H Veenstra; R Baumann; Nora Carroll; Pauline T Lukey; M Kidd; Nulda Beyers; Chris T Bolliger; Paul D van Helden; Gerhard Walzl
Changes in leucocyte and lymphocyte subsets during tuberculosis treatment; prominence of CD3dimCD56+ natural killer T cells in fast treatment responders.
Clinical and experimental immunology 2006;145(2):252-60.
2006: Rabia Johnson; Elizabeth M Streicher; Gail E Louw; Robin M Warren; Paul D van Helden; Thomas C Victor
Drug resistance in Mycobacterium tuberculosis.
Current issues in molecular biology 2006;8(2):97-111.
2006: Robin M Warren; Nicolaas C Gey van Pittius; M Barnard; Anneke C Hesseling; Erica Engelke; Marianna de Kock; M Cristina Gutierrez; G K Chege; Thomas C Victor; Eileen G Hoal; Paul D van Helden
Differentiation of Mycobacterium tuberculosis complex by PCR amplification of genomic regions of difference.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2006;10(7):818-22.
2006: G E Louw; Robin M Warren; P R Donald; M B Murray; M Bosman; Paul D van Helden; D B Young; Thomas C Victor
Frequency and implications of pyrazinamide resistance in managing previously treated tuberculosis patients.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2006;10(7):802-7.
2006: Z Lombard; A E Brune; Eileen G Hoal; Chantal L Babb; Paul D van Helden; J T Epplen; Liza Bornman
HLA class II disease associations in southern Africa.
Tissue antigens 2006;67(2):97-110.
2006: Paul D van Helden; Marlo Möller; Chantal L Babb; Robin Warren; Gerhard Walzl; Pieter Uys; Eileen G Hoal
TB epidemiology and human genetics.
Novartis Foundation symposium 2006;279():17-31; discussion 31-41, 216-9.
2006: Nicolaas C Gey van Pittius; Samantha L Sampson; Hyeyoung Lee; Yeun Kim; Paul D van Helden; Robin M Warren
Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions.
BMC evolutionary biology 2006;6():95.
2006: R Johnson; Annemarie M Jordaan; L Pretorius; Erica Engelke; Gian D van der Spuy; C Kewley; M Bosman; Paul D van Helden; Robin Warren; Thomas C Victor
Ethambutol resistance testing by mutation detection.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2006;10(1):68-73.
2005: Annelies van Rie; Thomas C Victor; Madalene Richardson; Rabia Johnson; Gian D van der Spuy; Emma J Murray; Nulda Beyers; Nicolaas C Gey van Pittius; Paul D van Helden; Robin M Warren
Reinfection and mixed infection cause changing Mycobacterium tuberculosis drug-resistance patterns.
American journal of respiratory and critical care medicine 2005;172(5):636-42.
2005: Suzanne Verver; Robin M Warren; Nulda Beyers; Madalene Richardson; Gian D van der Spuy; Martien Borgdorff; Donald A Enarson; Marcel A Behr; Paul D van Helden
Rate of reinfection tuberculosis after successful treatment is higher than rate of new tuberculosis.
American journal of respiratory and critical care medicine 2005;171(12):1430-5.
2005: H Simon Schaaf; Donald P Parkin; Heine I Seifart; Cedric J Werely; Peter B Hesseling; Paul D van Helden; J Stefan Maritz; Peter R Donald
Isoniazid pharmacokinetics in children treated for respiratory tuberculosis.
Archives of disease in childhood 2005;90(6):614-8.
2005: Du Toit Loots; Ian Wiid; Benedict J Page; Lodewyk J Mienie; Paul D van Helden
Melatonin prevents the free radical and MADD metabolic profiles induced by antituberculosis drugs in an animal model.
Journal of pineal research 2005;38(2):100-6.
2004: Eileen G Hoal; L A Lewis; Sarra E Jamieson; F Tanzer; Manda Rossouw; Thomas C Victor; R Hillerman; Nulda Beyers; Jenefer M Blackwell; Paul D van Helden
SLC11A1 (NRAMP1) but not SLC11A2 (NRAMP2) polymorphisms are associated with susceptibility to tuberculosis in a high-incidence community in South Africa.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2004;8(12):1464-71.
2004: Robin M Warren; Thomas C Victor; Elizabeth M Streicher; Madalene Richardson; Gian D van der Spuy; R Johnson; Violet Chihota; C Locht; Philip Supply; Paul D van Helden
Clonal expansion of a globally disseminated lineage of Mycobacterium tuberculosis with low IS6110 copy numbers.
Journal of clinical microbiology 2004;42(12):5774-82.
2004: Peter R Donald; Frik A Sirgel; A Venter; Donald P Parkin; Heine I Seifart; BW Van de Wal; Cedric J Werely; Paul D van Helden; J Stefan Maritz
The influence of human N-acetyltransferase genotype on the early bactericidal activity of isoniazid.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39(10):1425-30.
2004: Suzanne Verver; Robin M Warren; Zahn Munch; Emilia Vynnycky; Paul D van Helden; Madalene Richardson; Gian D van der Spuy; Donald A Enarson; Martien Borgdorff; Marcel A Behr; Nulda Beyers
Transmission of tuberculosis in a high incidence urban community in South Africa.
International journal of epidemiology 2004;33(2):351-7.
2004: Willie Githui; Annemarie M Jordaan; Ernest Juma; P Kinyanjui; FG Karimi; J Kimwomi; HK Meme; P Mumbi; Elizabeth M Streicher; Robin Warren; Paul D van Helden; Thomas C Victor
Identification of MDR-TB Beijing/W and other Mycobacterium tuberculosis genotypes in Nairobi, Kenya.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2004;8(3):352-60.
2004: Madalene Richardson; Gian D van der Spuy; Samantha L Sampson; Nulda Beyers; Paul D van Helden; Robin M Warren
Stability of polymorphic GC-rich repeat sequence-containing regions of Mycobacterium tuberculosis.
Journal of clinical microbiology 2004;42(3):1302-4.
2004: Robin M Warren; Thomas C Victor; Elizabeth M Streicher; Madalene Richardson; Nulda Beyers; Nicolaas C Gey van Pittius; Paul D van Helden
Patients with active tuberculosis often have different strains in the same sputum specimen.
American journal of respiratory and critical care medicine 2004;169(5):610-4.
2004: Ian Wiid; T Seaman; Eileen G Hoal; A J S Benade; Paul D van Helden
Total antioxidant levels are low during active TB and rise with anti-tuberculosis therapy.
IUBMB life 2004;56(2):101-6.
2004: Elizabeth M Streicher; Robin M Warren; C Kewley; J Simpson; N Rastogi; C Sola; Gian D van der Spuy; Paul D van Helden; Thomas C Victor
Genotypic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from rural districts of the Western Cape Province of South Africa.
Journal of clinical microbiology 2004;42(2):891-4.
2004: Thomas C Victor; Petra E W De Haas; Annemarie M Jordaan; Gian D van der Spuy; Madalene Richardson; Dick Van Soolingen; Paul D van Helden; Robin Warren
Molecular characteristics and global spread of Mycobacterium tuberculosis with a western cape F11 genotype.
Journal of clinical microbiology 2004;42(2):769-72.
2004: Suzanne Verver; Robin M Warren; Zahn Munch; Madalene Richardson; Gian D van der Spuy; Martien Borgdorff; Marcel A Behr; Nulda Beyers; Paul D van Helden
Proportion of tuberculosis transmission that takes place in households in a high-incidence area.
Lancet 2004;363(9404):212-4.
2003: Gian D van der Spuy; Robin M Warren; Madalene Richardson; Nulda Beyers; MA Behr; Paul D van Helden
Use of genetic distance as a measure of ongoing transmission of Mycobacterium tuberculosis.
Journal of clinical microbiology 2003;41(12):5640-4.
2003: Desiré Barnard; Karen Lehmann; Eileen G Hoal; Paul D van Helden; Thomas C Victor
The spectrum of mutations in TP53 in laryngeal cancer patients from a high-incidence population shows similarities to many of the known mutational hotspots.
Cancer genetics and cytogenetics 2003;145(2):126-32.
2003: Paul D van Helden
The economic divide and tuberculosis. Tuberculosis is not just a medical problem, but also a problem of social inequality and poverty.
EMBO reports 2003;4 Spec No():S24-8.
2003: Manda Rossouw; Hendrik J Nel; Graham S Cooke; Paul D van Helden; Eileen G Hoal
Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene.
Lancet 2003;361(9372):1871-2.
2003: H Simon Schaaf; I A Michaelis; Madalene Richardson; CN Booysen; Robert P Gie; R Warren; Paul D van Helden; Nulda Beyers
Adult-to-child transmission of tuberculosis: household or community contact?
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2003;7(5):426-31.
2003: David Meyer; Donald P Parkin; Heine I Seifart; J Stefan Maritz; Albertus H Engelbrecht; Cedric J Werely; Paul D van Helden
NAT2 slow acetylator function as a risk indicator for age-related cataract formation.
Pharmacogenetics 2003;13(5):285-9.
2003: S L Sampson; Robin M Warren; Madalene Richardson; Thomas C Victor; Annemarie M Jordaan; Gian D van der Spuy; Paul D van Helden
IS6110-mediated deletion polymorphism in the direct repeat region of clinical isolates of Mycobacterium tuberculosis.
Journal of bacteriology 2003;185(9):2856-66.
2003: Craig H Adams; Cedric J Werely; Thomas C Victor; Eileen G Hoal; Gawie Rossouw; Paul D van Helden
Allele frequencies for glutathione S-transferase and N-acetyltransferase 2 differ in African population groups and may be associated with oesophageal cancer or tuberculosis incidence.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2003;41(4):600-5.
2003: Pieter Uys; Paul D van Helden
On the nature of genetic changes required for the development of esophageal cancer.
Molecular carcinogenesis 2003;36(2):82-9.
2002: Robin M Warren; Elizabeth M Streicher; S L Sampson; Gian D van der Spuy; Madalene Richardson; D Nguyen; MA Behr; Thomas C Victor; Paul D van Helden
Microevolution of the direct repeat region of Mycobacterium tuberculosis: implications for interpretation of spoligotyping data.
Journal of clinical microbiology 2002;40(12):4457-65.
2002: Madalene Richardson; S W P van Lill; Gian D van der Spuy; Zahn Munch; CN Booysen; Nulda Beyers; Paul D van Helden; Robin M Warren
Historic and recent events contribute to the disease dynamics of Beijing-like Mycobacterium tuberculosis isolates in a high incidence region.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2002;6(11):1001-11.
2002: Nicolaas C Gey van Pittius; Robin M Warren; Paul D van Helden
ESAT-6 and CFP-10: what is the diagnosis?
Infection and immunity 2002;70(11):6509-10; author reply 6511.
2002: Robin M Warren; Elizabeth M Streicher; Salome Charalambous; Gavin Churchyard; Gian D van der Spuy; A D Grant; Paul D van Helden; Thomas C Victor
Use of spoligotyping for accurate classification of recurrent tuberculosis.
Journal of clinical microbiology 2002;40(10):3851-3.
2002: Nora Carroll; Madalene Richardson; Erica Engelke; Marianna de Kock; Carl Lombard; Paul D van Helden
Reduction of the rate of false-positive cultures of Mycobacterium tuberculosis in a laboratory with a high culture positivity rate.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2002;40(9):888-92.
2002: Thomas C Victor; Hyeyoung Lee; Sang-Nae Cho; Annemarie M Jordaan; Gian D van der Spuy; Paul D van Helden; Robin Warren
Molecular detection of early appearance of drug resistance during Mycobacterium tuberculosis infection.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2002;40(9):876-81.
2002: Madalene Richardson; Nora Carroll; Erica Engelke; Gian D van der Spuy; Faeeza Salker; Zahn Munch; Robert P Gie; Robin M Warren; Nulda Beyers; Paul D van Helden
Multiple Mycobacterium tuberculosis strains in early cultures from patients in a high-incidence community setting.
Journal of clinical microbiology 2002;40(8):2750-4.
2002: G S Sharaf-Eldin; Nageeb S Saeed; Mohammed E Hamid; Annemarie M Jordaan; Gian D van der Spuy; R M Warren; Paul D van Helden; T C Victor
Molecular analysis of clinical isolates of Mycobacterium tuberculosis collected from patients with persistent disease in the Khartoum region of Sudan.
The Journal of infection 2002;44(4):244-51.
2002: Robin M Warren; Gian D van der Spuy; Madalene Richardson; Nulda Beyers; Martien Borgdorff; MA Behr; Paul D van Helden
Calculation of the stability of the IS6110 banding pattern in patients with persistent Mycobacterium tuberculosis disease.
Journal of clinical microbiology 2002;40(5):1705-8.
2002: Thomas C Victor; Paul D van Helden; Robin Warren
Prediction of drug resistance in M. tuberculosis: molecular mechanisms, tools, and applications.
IUBMB life 2002;53(4-5):231-7.
2002: Robin M Warren; Gian D van der Spuy; Madalene Richardson; Nulda Beyers; CN Booysen; MA Behr; Paul D van Helden
Evolution of the IS6110-based restriction fragment length polymorphism pattern during the transmission of Mycobacterium tuberculosis.
Journal of clinical microbiology 2002;40(4):1277-82.
2002: Paul D van Helden; Robin M Warren; Thomas C Victor; Gian D van der Spuy; Madalene Richardson; Eileen Hoal-van Helden
Strain families of Mycobacterium tuberculosis.
Trends in microbiology 2002;10(4):167-8; author reply 168.
2001: S N van Helden; Eileen Hoal-van Helden; Paul D van Helden
Factors influencing peak expiratory flow in teenage boys.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2001;91(11):996-1000.
2001: Thomas C Victor; Annelies van Rie; Annemarie M Jordaan; Madalene Richardson; Gian D van der Spuy; Nulda Beyers; Paul D van Helden; Robin Warren
Sequence polymorphism in the rrs gene of Mycobacterium tuberculosis is deeply rooted within an evolutionary clade and is not associated with streptomycin resistance.
Journal of clinical microbiology 2001;39(11):4184-6.
2001: Annelies van Rie; Robin Warren; I Mshanga; Annemarie M Jordaan; Gian D van der Spuy; Madalene Richardson; J Simpson; Robert P Gie; D A Enarson; Nulda Beyers; Paul D van Helden; Thomas C Victor
Analysis for a limited number of gene codons can predict drug resistance of Mycobacterium tuberculosis in a high-incidence community.
Journal of clinical microbiology 2001;39(2):636-41.
2001: S L Sampson; Pauline T Lukey; R M Warren; Paul D van Helden; M Richardson; M J Everett
Expression, characterization and subcellular localization of the Mycobacterium tuberculosis PPE gene Rv1917c.
Tuberculosis (Edinburgh, Scotland) 2001;81(5-6):305-17.
2001: Robin M Warren; M Richardson; S L Sampson; Gian D van der Spuy; William Bourn; JH Hauman; H Heersma; Winston Hide; Nulda Beyers; Paul D van Helden
Molecular evolution of Mycobacterium tuberculosis: phylogenetic reconstruction of clonal expansion.
Tuberculosis (Edinburgh, Scotland) 2001;81(4):291-302.
2001: Eileen Hoal-van Helden; L A Stanton; R Warren; Madalene Richardson; Paul D van Helden
Diversity of in vitro cytokine responses by human macrophages to infection by mycobacterium tuberculosis strains.
Cell biology international 2001;25(1):83-90.
2001: Eileen Hoal-van Helden; D Hon; L A Lewis; Nulda Beyers; Paul D van Helden
Mycobacterial growth in human macrophages: variation according to donor, inoculum and bacterial strain.
Cell biology international 2001;25(1):71-81.
2000: Paul D van Helden; Eileen Hoal-van Helden
Molecular answers to tuberculous questions.
Lancet 2000;356 Suppl():s61.
2000: Robin M Warren; S L Sampson; Madalene Richardson; Gian D van der Spuy; Carl Lombard; Thomas C Victor; Paul D van Helden
Mapping of IS6110 flanking regions in clinical isolates of Mycobacterium tuberculosis demonstrates genome plasticity.
Molecular microbiology 2000;37(6):1405-16.
2000: H Simon Schaaf; Annelies van Rie; Robert P Gie; Nulda Beyers; Thomas C Victor; Paul D van Helden; Peter R Donald
Transmission of multidrug-resistant tuberculosis.
The Pediatric infectious disease journal 2000;19(8):695-9.
2000: H Simon Schaaf; Robert P Gie; Annelies van Rie; Heine I Seifart; Paul D van Helden; Mark F Cotton
Second episode of tuberculosis in an HIV-infected child: relapse or reinfection?
The Journal of infection 2000;41(1):100-3.
2000: Annelies van Rie; R Warren; M Richardson; Robert P Gie; Donald A Enarson; Nulda Beyers; Paul D van Helden
Classification of drug-resistant tuberculosis in an epidemic area.
Lancet 2000;356(9223):22-5.
1999: Annelies van Rie; Robin M Warren; Nulda Beyers; Robert P Gie; C N Classen; M Richardson; S L Sampson; Thomas C Victor; Paul D van Helden
Transmission of a multidrug-resistant Mycobacterium tuberculosis strain resembling "strain W" among noninstitutionalized, human immunodeficiency virus-seronegative patients.
The Journal of infectious diseases 1999;180(5):1608-15.
1999: Annelies van Rie; Robin Warren; Madalene Richardson; Thomas C Victor; Robert P Gie; D A Enarson; Nulda Beyers; Paul D van Helden
Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment.
The New England journal of medicine 1999;341(16):1174-9.
1999: M Vos; Robin M Warren; C J van Rensburg; JH Hauman; J T Epplen; Paul D van Helden
Rapid genomic diversification of Helicobacter pylori.
Electrophoresis 1999;20(7):1476-85.
1999: Eileen Hoal-van Helden; J Epstein; Thomas C Victor; D Hon; L A Lewis; Nulda Beyers; D Zurakowski; A B Ezekowitz; Paul D van Helden
Mannose-binding protein B allele confers protection against tuberculous meningitis.
Pediatric research 1999;45(4 Pt 1):459-64.
1999: C N Classen; R Warren; M Richardson; JH Hauman; R P Gie; J H Ellis; Paul D van Helden; Nulda Beyers
Impact of social interactions in the community on the transmission of tuberculosis in a high incidence area.
Thorax 1999;54(2):136-40.
1999: S L Sampson; R M Warren; Madalene Richardson; Gian D van der Spuy; Paul D van Helden
Disruption of coding regions by IS6110 insertion in Mycobacterium tuberculosis.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1999;79(6):349-59.
1999: Thomas C Victor; Annemarie M Jordaan; Annelies van Rie; Gian D van der Spuy; Madalene Richardson; Paul D van Helden; Robin Warren
Detection of mutations in drug resistance genes of Mycobacterium tuberculosis by a dot-blot hybridization strategy.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1999;79(6):343-8.
1998: Paul R Meyers; William Bourn; Lafras M Steyn; Paul D van Helden; Albert D Beyers; Gordon D Brown
Novel method for rapid measurement of growth of mycobacteria in detergent-free media.
Journal of clinical microbiology 1998;36(9):2752-4.
1998: Johan F Schoeman; A Morkel; Heine I Seifart; Donald P Parkin; Paul D van Helden; Richard H Hewlett; Peter R Donald
Massive posterior fossa tuberculous abscess developing in a young child treated for miliary tuberculosis. Possible role of very rapid acetylation of isoniazid.
Pediatric neurosurgery 1998;29(2):64-8.
1997: Thomas C Victor; R Warren; J L Butt; Annemarie M Jordaan; J V Felix; A Venter; Frik A Sirgel; H Simon Schaaf; Peter R Donald; M Richardson; Michael Cynamon; Paul D van Helden
Genome and MIC stability in Mycobacterium tuberculosis and indications for continuation of use of isoniazid in multidrug-resistant tuberculosis.
Journal of medical microbiology 1997;46(10):847-57.
1997: F J Cilliers; Robin M Warren; JH Hauman; Ian Wiid; Paul D van Helden
Oligonucleotide (GTG)5 as an epidemiological tool in the study of nontuberculous mycobacteria.
Journal of clinical microbiology 1997;35(6):1545-9.
1997: Donald P Parkin; S Vandenplas; FJ Botha; M L Vandenplas; Heine I Seifart; Paul D van Helden; B J van der Walt; Peter R Donald; Pieter van Jaarsveld
Trimodality of isoniazid elimination: phenotype and genotype in patients with tuberculosis.
American journal of respiratory and critical care medicine 1997;155(5):1717-22.
1988: Paul D van Helden
Use of (35)s nucleotides for DNA sequencing.
Methods in molecular biology (Clifton, N.J.) 1988;4():81-8.
1988: Paul D van Helden; Eileen G Hoal
Plasmid preparation on sephacryl s1000.
Methods in molecular biology (Clifton, N.J.) 1988;4():69-74.
1988: Paul D van Helden
Use of elutips to purify DNA.
Methods in molecular biology (Clifton, N.J.) 1988;4():61-7.