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Luc Van Kaer

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Vrajesh V Parekh; Kelli L Boyd; Timothy L Cover; Jennifer A Gaddy; Danyvid Olivares-Villagómez; Janice A Williams; Lan Wu; Jianhua Zhang; Wei-Xing Zong; Luc Van Kaer
Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of vps34.
Charles T Spencer; Luc Van Kaer; Mu Zheng; Stephanie B Conant; Srdjan M Dragovic; Jennifer J Gray; Andrew J Link; Magdalini Moutaftsi; Xinnan Niu; Parimal Samir; Alessandro Sette; Sebastian Joyce
Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses.
Yasuhiro Andoh; Koji Eshima; Satoshi Fujii; Naoki Ishimori; Yukihito Nakai; Hisako Ogura; Hironori Okuno; Kazunori Onoé; Tatsuro Otani; Masashi Satoh; Kentaro Shimano; Hidekazu Tamauchi; Hiroyuki Tsutsui; Luc Van Kaer; Kazuya Iwabuchi
Natural killer T cells are required for lipopolysaccharide-mediated enhancement of atherosclerosis in apolipoprotein E-deficient mice.

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2013: Vrajesh V Parekh; Kelli L Boyd; Timothy L Cover; Jennifer A Gaddy; Danyvid Olivares-Villagómez; Janice A Williams; Lan Wu; Jianhua Zhang; Wei-Xing Zong; Luc Van Kaer
Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of vps34.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(10):5086-101.
2013: Charles T Spencer; Luc Van Kaer; Mu Zheng; Stephanie B Conant; Srdjan M Dragovic; Jennifer J Gray; Andrew J Link; Magdalini Moutaftsi; Xinnan Niu; Parimal Samir; Alessandro Sette; Sebastian Joyce
Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses.
European journal of immunology 2013;43(5):1162-72.
2013: Yasuhiro Andoh; Koji Eshima; Satoshi Fujii; Naoki Ishimori; Yukihito Nakai; Hisako Ogura; Hironori Okuno; Kazunori Onoé; Tatsuro Otani; Masashi Satoh; Kentaro Shimano; Hidekazu Tamauchi; Hiroyuki Tsutsui; Luc Van Kaer; Kazuya Iwabuchi
Natural killer T cells are required for lipopolysaccharide-mediated enhancement of atherosclerosis in apolipoprotein E-deficient mice.
Immunobiology 2013;218(4):561-9.
2013: Vrajesh V Parekh; Keith T Wilson; Lan Wu; Danyvid Olivares-Villagómez; Luc Van Kaer
Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):1948-60.
2013: Michael J Rosen; Amar B Singh; Luc Van Kaer; M Kay Washington; Jörn-Hendrik Weitkamp; Christopher S Williams; Rupesh Chaturvedi; Lori A Coburn; Scott S Coggeshall; Lindsay A Kuhnhein; Elizabeth M McDonough; Preston D Moore; R Stokes Peebles; Fang Yan; Keith T Wilson
STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(4):1849-58.
2013: Yogesh Singh; Mrutyunjay Suar; Sultan Tousif; Luc Van Kaer; William R Bishai; Samit Chatterjee; Ved Prakash Dwivedi; Vandana Kaul; Alka Mehra; Gobardhan Das
Mycobacterium tuberculosis controls microRNA-99b (miR-99b) expression in infected murine dendritic cells to modulate host immunity.
The Journal of biological chemistry 2013;288(7):5056-61.
2013: Luc Van Kaer; Vrajesh V Parekh; Lan Wu
Invariant natural killer T cells as sensors and managers of inflammation.
Trends in immunology 2013;34(2):50-8.
2012: Vandana Kaul; Marc Peters-Golden; Yogesh Singh; Luc Van Kaer; Debapriya Bhattacharya; William R Bishai; Gobardhan Das
An important role of prostanoid receptor EP2 in host resistance to Mycobacterium tuberculosis infection in mice.
The Journal of infectious diseases 2012;206(12):1816-25.
2012: Ved Prakash Dwivedi; Durbaka Vijay Raghva Prasad; Luc Van Kaer; Debapriya Bhattacharya; William R Bishai; Samit Chatterjee; Debprasad Chattopadhyay; Gobardhan Das
Mycobacterium tuberculosis directs T helper 2 cell differentiation by inducing interleukin-1β production in dendritic cells.
The Journal of biological chemistry 2012;287(40):33656-63.
2012: Vandana Kaul; Luc Van Kaer; Gobardhan Das; Jyoti Das
Prostanoid receptor 2 signaling protects T helper 2 cells from BALB/c mice against activation-induced cell death.
The Journal of biological chemistry 2012;287(30):25434-9.
2012: Lan Wu; David H Wasserman; Brandon Williams; Gurdyal S Besra; Deanna P Bracy; Curtis L Gabriel; Sungjune Kim; Jefferson P Lomenick; Pamela A Marks-Shulman; Yanice V Mendez-Fernandez; Vrajesh V Parekh; Robyn A Tamboli; Luc Van Kaer
Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):E1143-52.
2012: Ved Prakash Dwivedi; Durbaka Vijay Raghva Prasad; Sultan Tousif; Luc Van Kaer; Debapriya Bhattacharya; Jyoti Das; Gobardhan Das
Transforming growth factor-β protein inversely regulates in vivo differentiation of interleukin-17 (IL-17)-producing CD4+ and CD8+ T cells.
The Journal of biological chemistry 2012;287(5):2943-7.
2012: Mohd Moin Khan; Nishant Kumar Pandey; Yogesh Singh; Sultan Tousif; Luc Van Kaer; Neel Sarovar Bhavesh; Samit Chatterjee; Jyoti Das; Ved Prakash Dwivedi; Gobardhan Das
CD4+ T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4+ T cells to direct T helper 2 cell differentiation.
The Journal of biological chemistry 2012;287(4):2830-5.
2011: Samit Chatterjee; Debprasad Chattopadhyay; Ved Prakash Dwivedi; Pawan Sharma; Imran Siddiqui; Yogesh Singh; Luc Van Kaer; Gobardhan Das
Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner.
PLoS pathogens 2011;7(11):e1002378.
2011: Yujun Huang; Mitchell Kronenberg; Alexandre Larange; Danyvid Olivares-Villagómez; Yunji Park; Stephen P Schoenberger; Michael A Teitell; Luc Van Kaer; Yiran Wang-Zhu; Ninan Abraham; Ramon Arens; Iván Bernardo; Beatrix Grubeck-Loebenstein; Dietmar Herndler-Brandstetter; Hilde Cheroutre
Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.
Nature immunology 2011;12(11):1086-95.
2011: James K Oeser; Vrajesh V Parekh; Lynley D Pound; Suparna A Sarkar; Luc Van Kaer; Yingda Wang; Randall Wong; John C Hutton; Naresh K Jegadeesh; Catherine E Lee; Richard M O'Brien
Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice.
Diabetes 2011;60(11):2922-7.
2011: Danyvid Olivares-Villagómez; Vrajesh V Parekh; M Blanca Piazuelo; Kaitlyn E Ryan; Kshipra Singh; Holly M Scott Algood; Keith T Wilson; Luc Van Kaer
Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(8):4051-60.
2011: Fu-Dong Shi; Antonio La Cava; Hans-Gustaf Ljunggren; Luc Van Kaer
Organ-specific features of natural killer cells.
Nature reviews. Immunology 2011;11(10):658-71.
2011: Srdjan M Dragovic; Tim Elliott; Timothy Hill; Sungjune Kim; Derry C Roopenian; Diane Scott; Luc Van Kaer; Gregory J Christianson; Sebastian JOYCE
Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(12):6683-92.
2011: Junwei Hao; Denise Campagnolo; Ruolan Liu; Wenhua Piao; Samuel Shi; Baoyang Hu; Rong Xiang; Qinghua Zhou; Timothy Vollmer; Luc Van Kaer; Antonio La Cava; Fu-Dong Shi
Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation.
Annals of neurology 2011;69(4):721-34.
2011: Lisa A Mannik; Ian Chin-Yee; Shayan Sharif; Luc Van Kaer; Terry L Delovitch; S M Mansour Haeryfar
Engagement of glycosylphosphatidylinositol-anchored proteins results in enhanced mouse and human invariant natural killer T cell responses.
Immunology 2011;132(3):361-75.
2011: Marianne J van den Heuvel; Nitan Garg; Luc Van Kaer; S M Mansour Haeryfar
NKT cell costimulation: experimental progress and therapeutic promise.
Trends in molecular medicine 2011;17(2):65-77.
2011: Lan Wu; Luc Van Kaer
Natural killer T cells in health and disease.
Frontiers in bioscience (Scholar edition) 2011;3():236-51.
2011: Luc Van Kaer; Vrajesh V Parekh; Lan Wu
Invariant NK T cells: potential for immunotherapeutic targeting with glycolipid antigens.
Immunotherapy 2011;3(1):59-75.
2011: Luc Van Kaer
Glatiramer acetate for treatment of MS: regulatory B cells join the cast of players.
Experimental neurology 2011;227(1):19-23.
2011: Jeremy Goettel; Holly M Scott Algood; Danyvid Olivares-Villagómez; M Kay Washington; Rupesh Chaturvedi; Keith T Wilson; Luc Van Kaer; D Brent Polk
KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production.
Gastroenterology 2011;140(1):265-74.
2011: Luc Van Kaer; Vrajesh V Parekh; Lan Wu
Invariant natural killer T cells: bridging innate and adaptive immunity.
Cell and tissue research 2011;343(1):43-55.
2010: Shilpa Raghuvanshi; Pawan Sharma; Sarman Singh; Luc Van Kaer; Gobardhan Das
Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21653-8.
2010: Danyvid Olivares-Villagómez; Luc Van Kaer
TL and CD8αα: Enigmatic partners in mucosal immunity.
Immunology letters 2010;134(1):1-6.
2010: Luc Van Kaer
Comeback kids: CD8(+) suppressor T cells are back in the game.
The Journal of clinical investigation 2010;120(10):3432-4.
2010: Nicole A Braun; Yanice V Mendez-Fernandez; Roman Covarrubias; Steven A Porcelli; Paul B Savage; Hideo Yagita; Luc Van Kaer; Amy S Major
Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(9):1758-65.
2010: Junwei Hao; Ruolan Liu; Wenhua Piao; Qinghua Zhou; Timothy L Vollmer; Denise I Campagnolo; Rong Xiang; Antonio La Cava; Luc Van Kaer; Fu-Dong Shi
Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology.
The Journal of experimental medicine 2010;207(9):1907-21.
2010: Luc Van Kaer; Sebastian JOYCE
The hunt for iNKT cell antigens: alpha-galactosidase-deficient mice to the rescue?
Immunity 2010;33(2):143-5.
2010: Kristen L Hoek; Laura E Gordy; Patrick L Collins; Vrajesh V Parekh; Thomas M Aune; Sebastian JOYCE; James W Thomas; Luc Van Kaer; Eric Sebzda
Follicular B cell trafficking within the spleen actively restricts humoral immune responses.
Immunity 2010;33(2):254-65.
2010: Lingyun Zu; Djahida Bedja; Karen Fox-Talbot; Kathleen L Gabrielson; Luc Van Kaer; Lewis C Becker; Zheqing Cai
Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice.
Journal of molecular and cellular cardiology 2010;49(1):5-15.
2010: Ruolan Liu; Qinghua Zhou; Antonio La Cava; Denise I Campagnolo; Luc Van Kaer; Fu-Dong Shi
Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia.
European journal of immunology 2010;40(6):1577-89.
2009: Jyoti Das; Guangwen Ren; Liying Zhang; Arthur I Roberts; Xin Zhao; Alfred L M Bothwell; Luc Van Kaer; Yufang Shi; Gobardhan Das
Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation.
The Journal of experimental medicine 2009;206(11):2407-16.
2009: Martin L Moore; Dawn C Newcomb; Vrajesh V Parekh; Luc Van Kaer; Robert D Collins; Weisong Zhou; Kasia Goleniewska; Michael H Chi; Daphne Mitchell; Joshua A Boyce; Joan E Durbin; Carla Sturkie; R Stokes Peebles
STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):2016-26.
2009: Lan Wu; Curtis Gabriel; Vrajesh V Parekh; Luc Van Kaer
Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities.
Tissue antigens 2009;73(6):535-45.
2009: Leen Moens; Axel Jeurissen; Stefan Nierkens; Louis Boon; Luc Van Kaer; Ahmad Kasran; Greet Wuyts; Jan L Ceuppens; Xavier Bossuyt
Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice.
Infection and immunity 2009;77(5):1976-80.
2009: Lan Wu; Luc Van Kaer
Natural killer T cells and autoimmune disease.
Current molecular medicine 2009;9(1):4-14.
2009: Shanmugalakshmi Sadagopal; Miriam Braunstein; Cynthia C Hager; Jie Wei; Alexandria K Daniel; Markian R Bochan; Ian Crozier; Nathaniel E Smith; Hiriam O Gates; Louise Barnett; Luc Van Kaer; James O Price; Timothy S Blackwell; Spyros A Kalams; Douglas S Kernodle
Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG.
PloS one 2009;4(5):e5531.
2008: Sungjune Kim; Saif Lalani; Vrajesh V Parekh; Lan Wu; Luc Van Kaer
Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants.
Expert review of vaccines 2008;7(10):1519-32.
2008: Zheqing Cai; Zhenyun Shen; Luc Van Kaer; Lewis C Becker
Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(12):4248-57.
2008: Danyvid Olivares-Villagómez; Yanice V Mendez-Fernandez; Vrajesh V Parekh; Saif Lalani; Tiffaney L Vincent; Hilde Cheroutre; Luc Van Kaer
Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17931-6.
2008: Hongyan Diao; Kazuya Iwabuchi; Lanjuan Li; Kazunori Onoe; Luc Van Kaer; Shigeyuki Kon; Yoshinari Saito; Junko Morimoto; David T Denhardt; Susan Rittling; Toshimitsu Uede
Osteopontin regulates development and function of invariant natural killer T cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(41):15884-9.
2008: Eric Adeeku; Prathyusha Gudapati; Yanice V Mendez-Fernandez; Luc Van Kaer; Mark Boothby
Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(27):9307-12.
2008: Sebastian Joyce; Luc Van Kaer
Lung NKT cell commotion takes your breath away.
Nature medicine 2008;14(6):609-10.
2008: Chang-Yuan Ni; Zhao-Hui Wu; William Florence; Vrajesh V Parekh; Maria Pia Arrate; Steven Pierce; Brock Schweitzer; Luc Van Kaer; Sebastian JOYCE; shigeki miyamoto; Dean W Ballard; Eugene M Oltz
Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7107-11.
2008: Sungjune Kim; Saif Lalani; Vrajesh V Parekh; Tiffaney L Vincent; Lan Wu; Luc Van Kaer
Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice.
The Journal of clinical investigation 2008;118(6):2301-15.
2008: Sebastian JOYCE; Luc Van Kaer
Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile.
Cell host & microbe 2008;3(5):275-7.
2008: Ayako Yamaura; Chie Hotta; Masatoshi Nakazawa; Luc Van Kaer; Mutsuhiko Minami
Human invariant Valpha24+ natural killer T cells acquire regulatory functions by interacting with IL-10-treated dendritic cells.
Blood 2008;111(8):4254-63.
2008: Luc Van Kaer
Pillars article: antigen presentation: discovery of the peptide TAP.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2723-4.
2008: Yukie Matsumoto; Nobuhiro Yuki; Luc Van Kaer; Koichi Furukawa; Koichi Hirata; Masahiko Sugita
Cutting edge: Guillain-Barre syndrome-associated IgG responses to gangliosides are generated independently of CD1 function in mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):39-43.
2007: Lan Wu; Luc Van Kaer
Role of NKT cells in the digestive system. II. NKT cells and diabetes.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(5):G919-22.
2007: Monica M Medeiros; Jaqueline R Peixoto; Ana-Carolina Oliveira; Larissa Cardilo-Reis; Vera Lucia G Koatz; Luc Van Kaer; José O Previato; Lucia Mendonça-Previato; Alberto Nobrega; Maria Bellio
Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi.
Journal of leukocyte biology 2007;82(3):488-96.
2007: Krishna Puttaparthi; Luc Van Kaer; Jeffrey L Elliott
Assessing the role of immuno-proteasomes in a mouse model of familial ALS.
Experimental neurology 2007;206(1):53-8.
2007: Luc Van Kaer
NKT cells: T lymphocytes with innate effector functions.
Current opinion in immunology 2007;19(3):354-64.
2007: Jun-Qi Yang; Xiangshu Wen; Hongzhu Liu; Gbolahan Folayan; Xin Dong; Min Zhou; Luc Van Kaer; Ram Raj Singh
Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model.
Arthritis and rheumatism 2007;56(4):1219-33.
2007: Vrajesh V Parekh; Saif Lalani; Luc Van Kaer
The in vivo response of invariant natural killer T cells to glycolipid antigens.
International reviews of immunology 2007;26(1-2):31-48.
2006: Jyoti Das; PAUL EYNOTT; Ray Jupp; Alfred L M Bothwell; Luc Van Kaer; Yufang Shi; Gobardhan Das
Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation.
Nature medicine 2006;12(12):1345-6; author reply 1347.
2006: Gobardhan Das; Jyoti Das; PAUL EYNOTT; Yingyu Zhang; Alfred L M Bothwell; Luc Van Kaer; Yufang Shi
Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases.
The Journal of experimental medicine 2006;203(12):2603-11.
2006: Dai Takagi; Kazuya Iwabuchi; Masanori Maeda; Yuji Nakamaru; Yasushi Furuta; Satoshi Fukuda; Luc Van Kaer; Jun Nishihira; Kazunori Onoé
Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice.
International journal of molecular medicine 2006;18(5):829-36.
2006: Fu-Dong Shi; Luc Van Kaer
Reciprocal regulation between natural killer cells and autoreactive T cells.
Nature reviews. Immunology 2006;6(10):751-60.
2006: Luc Van Kaer
Role of invariant natural killer T cells in immune regulation and as potential therapeutic targets in autoimmune disease.
Expert review of clinical immunology 2006;2(5):745-57.
2006: Jelena S Bezbradica; Laura E Gordy; Aleksandar Stanic; Srdjan Dragovic; Timothy Hill; Jacek Hawiger; Derya Unutmaz; Luc Van Kaer; Sebastian JOYCE
Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny.
Immunity 2006;25(3):487-97.
2006: Luc Van Kaer; Sebastian Joyce
Viral evasion of antigen presentation: not just for peptides anymore.
Nature immunology 2006;7(8):795-7.
2006: Antonio La Cava; Luc Van Kaer
CD4+CD25+ Tregs and NKT cells: regulators regulating regulators.
Trends in immunology 2006;27(7):322-7.
2006: Gourapura J Renukaradhya; Venkataraman Sriram; Wenjun Du; Jacquelyn Gervay-Hague; Luc Van Kaer; Randy R Brutkiewicz
Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo.
International journal of cancer. Journal international du cancer 2006;118(12):3045-53.
2006: Amy S Major; Sebastian JOYCE; Luc Van Kaer
Lipid metabolism, atherogenesis and CD1-restricted antigen presentation.
Trends in molecular medicine 2006;12(6):270-8.
2006: Ruolan Liu; Luc Van Kaer; Antonio La Cava; Mary Price; Denise I Campagnolo; Mary Collins; Deborah A Young; Timothy L Vollmer; Fu-Dong Shi
Autoreactive T cells mediate NK cell degeneration in autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5247-54.
2006: Jingbo Yan; Vrajesh V Parekh; Yanice V Mendez-Fernandez; Danyvid Olivares-Villagómez; Srdjan Dragovic; Timothy Hill; Derry C Roopenian; Sebastian JOYCE; Luc Van Kaer
In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules.
The Journal of experimental medicine 2006;203(3):647-59.
2006: Karla A Eger; Mark S Sundrud; Alison A Motsinger; Michelle Tseng; Luc Van Kaer; Derya Unutmaz
Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions.
PloS one 2006;1():e50.
2006: Amy S Major; Ram R Singh; Sebastian JOYCE; Luc Van Kaer
The role of invariant natural killer T cells in lupus and atherogenesis.
Immunologic research 2006;34(1):49-66.
2005: Ruolan Liu; Antonio La Cava; Xue-Feng Bai; Youngheun Jee; Mary Price; Denise I Campagnolo; Premkumar Christadoss; Timothy L Vollmer; Luc Van Kaer; Fu-Dong Shi
Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):7898-904.
2005: Joshua Beilke; Nathan R Kuhl; Luc Van Kaer; Ronald G Gill
NK cells promote islet allograft tolerance via a perforin-dependent mechanism.
Nature medicine 2005;11(10):1059-65.
2005: Vrajesh V Parekh; Michael T Wilson; Danyvid Olivares-Villagómez; Avneesh K Singh; Lan Wu; Chyung-Ru Wang; Sebastian JOYCE; Luc Van Kaer
Glycolipid antigen induces long-term natural killer T cell anergy in mice.
The Journal of clinical investigation 2005;115(9):2572-83.
2005: Ming Chen; Piotr Tabaczewski; Steven M Truscott; Luc Van Kaer; Iwona Stroynowski
Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):1047-55.
2005: Luc Van Kaer; Sebastian JOYCE
Innate immunity: NKT cells in the spotlight.
Current biology : CB 2005;15(11):R429-31.
2005: Jelena S Bezbradica; Aleksandar Stanic; Naoto Matsuki; Helene Bour-Jordan; Jeffrey A Bluestone; James W Thomas; Derya Unutmaz; Luc Van Kaer; Sebastian JOYCE
Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4696-705.
2005: Jelena S Bezbradica; Timothy Hill; Aleksandar Stanic; Luc Van Kaer; Sebastian JOYCE
Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):5114-9.
2005: Avneesh K Singh; Jun-Qi Yang; Vrajesh V Parekh; Jie Wei; Chyung-Ru Wang; Sebastian JOYCE; Ram R Singh; Luc Van Kaer
The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in mice.
European journal of immunology 2005;35(4):1143-54.
2005: Scott H Robbins; Marlowe S Tessmer; Luc Van Kaer; Laurent Brossay
Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation.
European journal of immunology 2005;35(3):757-65.
2005: Vrajesh V Parekh; Michael T Wilson; Luc Van Kaer
iNKT-cell responses to glycolipids.
Critical reviews in immunology 2005;25(3):183-213.
2005: Luc Van Kaer
alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles.
Nature reviews. Immunology 2005;5(1):31-42.
2005: Daigo Hashimoto; Shoji Asakura; Sachiko Miyake; Takashi Yamamura; Luc Van Kaer; Chen Liu; Mitsune Tanimoto; Takanori Teshima
Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):551-6.
2004: Amy S Major; Michael T Wilson; Jennifer L McCaleb; Yan Ru Su; Aleksandar Stanic; Sebastian JOYCE; Luc Van Kaer; Sergio Fazio; MacRae F Linton
Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(12):2351-7.
2004: Hongyan Diao; Shigeyuki Kon; Kazuya Iwabuchi; Chiemi Kimura; Junko Morimoto; Daisuke Ito; Tatsuya Segawa; Masahiro Maeda; Junji Hamuro; Toshinori Nakayama; Masaru Taniguchi; Hideo Yagita; Luc Van Kaer; Kazunori Onóe; David T Denhardt; Susan R Rittling; Toshimitsu Uede
Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.
Immunity 2004;21(4):539-50.
2004: Yukihito Nakai; Kazuya Iwabuchi; Satoshi Fujii; Naoki Ishimori; Nyambayar Dashtsoodol; Keiko Watano; Tetsuya Mishima; Chikako Iwabuchi; Shinya Tanaka; Jelena S Bezbradica; Toshinori Nakayama; Masaru Taniguchi; Sachiko Miyake; Takashi Yamamura; Akira Kitabatake; Sebastian JOYCE; Luc Van Kaer; Kazunori Onoé
Natural killer T cells accelerate atherogenesis in mice.
Blood 2004;104(7):2051-9.
2004: LiQi Li; Barbara A Sullivan; Carla J Aldrich; Mark J Soloski; James Forman; Andres G Grandea; Peter E Jensen; Luc Van Kaer
Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3707-15.
2004: Vrajesh V Parekh; Avneesh K Singh; Michael T Wilson; Danyvid Olivares-Villagómez; Jelena S Bezbradica; Hiroko Inazawa; Hiromi Ehara; Teruyuki Sakai; Isao Serizawa; Lan Wu; Chyung-Ru Wang; Sebastian JOYCE; Luc Van Kaer
Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3693-706.
2004: Luc Van Kaer
Natural killer T cells as targets for immunotherapy of autoimmune diseases.
Immunology and cell biology 2004;82(3):315-22.
2004: Jun-Qi Yang; Taehoon Chun; Hongzhu Liu; Seokmann Hong; Hai Bui; Luc Van Kaer; Chyung-Ru Wang; Ram Raj Singh
CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice.
European journal of immunology 2004;34(6):1723-32.
2004: Keishi Adachi; Hiroko Tsutsui; Ekihiro Seki; Hiroki Nakano; Kazuyoshi Takeda; Ko Okumura; Luc Van Kaer; Kenji Nakanishi
Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice.
International immunology 2004;16(6):787-98.
2004: Aleksandar Stanic; Jelena S Bezbradica; Jang-June Park; Luc Van Kaer; Mark Boothby; Sebastian JOYCE
Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4667-71.
2004: Tonya J Webb; Yinling Lin; Philip M Spence; Luc Van Kaer; Randy R Brutkiewicz
CD1d1-dependent control of the magnitude of an acute antiviral immune response.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3454-61.
2004: Dale I Godfrey; H Robson MacDonald; Mitchell Kronenberg; Mark J Smyth; Luc Van Kaer
NKT cells: what's in a name?
Nature reviews. Immunology 2004;4(3):231-7.
2004: Katrin A Mühlen; Jens Schümann; Frederick Wittke; Steffen Stenger; Nico van Rooijen; Luc Van Kaer; Gisa Tiegs
NK cells, but not NKT cells, are involved in Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):3034-41.
2004: Heth R Turnquist; Jason L Petersen; Shanna E Vargas; Mary M McIlhaney; Elliott Bedows; Werner E Mayer; Andres G Grandea; Luc Van Kaer; Joyce C Solheim
The Ig-like domain of tapasin influences intermolecular interactions.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):2976-84.
2004: Aleksandar Stanic; Jelena S Bezbradica; Jang-June Park; Naoto Matsuki; Ana L Mora; Luc Van Kaer; Mark Boothby; Sebastian JOYCE
NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2265-73.
2004: Luc Van Kaer
Regulation of immune responses by CD1d-restricted natural killer T cells.
Immunologic research 2004;30(2):139-53.
2003: Jianhua Zhang; Mei Dong; Lily Li; Yunxia Fan; Purnima Pathre; Jin Dong; Danwen Lou; James M Wells; Danyvid Olivares-Villagómez; Luc Van Kaer; Xiaodong Wang; Mingli Xu
Endonuclease G is required for early embryogenesis and normal apoptosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15782-7.
2003: Haobo Liang; Clint VanValkenburgh; Xuemin Chen; Chris Mullins; Luc Van Kaer; Neil Green; Hong Fang
Genetic complementation in yeast reveals functional similarities between the catalytic subunits of mammalian signal peptidase complex.
The Journal of biological chemistry 2003;278(51):50932-9.
2003: Feng Zhang; Zhiyan Liang; Naoto Matsuki; Luc Van Kaer; Sebastian JOYCE; Edward K Wakeland; Thomas M Aune
A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4613-20.
2003: Aleksandar Stanic; R Shashidharamurthy; Jelena S Bezbradica; Naoto Matsuki; Yoshitaka Yoshimura; Sachiko Miyake; Eun Young Choi; Todd D Schell; Luc Van Kaer; Satvir S Tevethia; Derry C Roopenian; Takashi Yamamura; Sebastian JOYCE
Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected].
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4539-51.
2003: Jun-Qi Yang; Vijay Saxena; Honglin Xu; Luc Van Kaer; Chyung-Ru Wang; Ram Raj Singh
Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4439-46.
2003: Michael T Wilson; Cecilia Johansson; Danyvid Olivares-Villagómez; Avneesh K Singh; Aleksandar Stanic; Chyung-Ru Wang; Sebastian JOYCE; Mary Jo Wick; Luc Van Kaer
The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10913-8.
2003: Jun-Qi Yang; Avneesh K Singh; Michael T Wilson; Minoru Satoh; Aleksandar Stanic; Jang-June Park; Seokmann Hong; Stephan D Gadola; Akiei Mizutani; Srinivasa R Kakumanu; Westley H Reeves; Vincenzo Cerundolo; Sebastian JOYCE; Luc Van Kaer; Ram Raj Singh
Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):2142-53.
2003: Hui Shao; Luc Van Kaer; Sheher L Sun; Henry J Kaplan; Deming Sun
Infiltration of the inflamed eye by NKT cells in a rat model of experimental autoimmune uveitis.
Journal of autoimmunity 2003;21(1):37-45.
2003: Alison A Motsinger; Agnes M Azimzadeh; Aleksandar Stanic; R Paul Johnson; Luc Van Kaer; Sebastian JOYCE; Derya Unutmaz
Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells.
Journal of virology 2003;77(14):8153-8.
2003: Peter Chefalo; Andres G Grandea; Luc Van Kaer; Clifford V Harding
Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(12):5825-33.
2003: Naoto Matsuki; Aleksandar Stanic; Monica E Embers; Luc Van Kaer; Laurence Morel; Sebastian JOYCE
Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5429-37.
2003: Tomohiro Yoshimoto; Booki Min; Takaaki Sugimoto; Nobuki Hayashi; Yuriko Ishikawa; Yuki Sasaki; Hitomi Hata; Kazuyoshi Takeda; Ko Okumura; Luc Van Kaer; William Paul; Kenji Nakanishi
Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice.
The Journal of experimental medicine 2003;197(8):997-1005.
2003: Aleksandar Stanic; A Dharshan De Silva; Jang-June Park; Venkataraman Sriram; Shinichi Ichikawa; Yoshio Hirabyashi; Kyoko Hayakawa; Luc Van Kaer; Randy R Brutkiewicz; Sebastian JOYCE
Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1849-54.
2003: Sebastian JOYCE; Luc Van Kaer
CD1-restricted antigen presentation: an oily matter.
Current opinion in immunology 2003;15(1):95-104.
2002: Yoshihiro Hayakawa; Kazuyoshi Takeda; Hideo Yagita; Mark J Smyth; Luc Van Kaer; Ko Okumura; Ikuo Saiki
IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide.
Blood 2002;100(5):1728-33.
2002: Christelle Faveeuw; Véronique Angeli; Josette Fontaine; Charles R Maliszewski; André Capron; Luc Van Kaer; Muriel Moser; Monique Capron; François Trottein
Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):906-12.
2002: Lennart T Mars; VERONIQUE LALOUX; Karine Goude; Sabine Desbois; Abdelhadi Saoudi; Luc Van Kaer; Hans Lassmann; André Herbelin; Agnès Lehuen; Roland S Liblau
Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6007-11.
2002: Idania Marrero Suárez; Luiz Alberto Benvenutti; Irene Noronh; Luc Van Kaer; Jorge Kalil; Verônica Coelho
Rejection of grafts with no H-2 disparity in TAP1 mutant mice: CD4 T cells are important effector cells and self H-2b class I molecules are target.
Transplant immunology 2002;9(2-4):101-10.
2002: Michael T Wilson; Avneesh K Singh; Luc Van Kaer
Immunotherapy with ligands of natural killer T cells.
Trends in molecular medicine 2002;8(5):225-31.
2002: Teresa Johnson; Seokmann Hong; Luc Van Kaer; Yasuhiko Koezuka; Barney S Graham
NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus.
Journal of virology 2002;76(9):4294-303.
2002: Stephen M Tompkins; Josette Padilla; Mauro C Dal Canto; Jenny P-Y Ting; Luc Van Kaer; Stephen D Miller
De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):4173-83.
2002: Alison A Motsinger; David W Haas; Aleksandar Stanic; Luc Van Kaer; Sebastian JOYCE; Derya Unutmaz
CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection.
The Journal of experimental medicine 2002;195(7):869-79.
2002: Gloria Gonzalez-Aseguinolaza; Luc Van Kaer; Cornelia C Bergmann; James M Wilson; John Schmieg; Mitchell Kronenberg; Toshinori Nakayama; Masaru Taniguchi; Yasuhiko Koezuka; Moriya Tsuji
Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines.
The Journal of experimental medicine 2002;195(5):617-24.
2002: Martin Mempel; Catherine Ronet; Felipe Suarez; Martine GILLERON; Germain Puzo; Luc Van Kaer; Agnès Lehuen; Philippe Kourilsky; Gabriel Gachelin
Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):365-71.
2001: Avneesh K Singh; Michael T Wilson; Seokmann Hong; Danyvid Olivares-Villagómez; Caigan Du; Aleksandar Stanic; Sebastian JOYCE; Subramaniam Sriram; Yasuhiko Koezuka; Luc Van Kaer
Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2001;194(12):1801-11.
2001: K Adachi; Hiroko Tsutsui; S Kashiwamura; Ekihiro Seki; Hiroki Nakano; Osamu Takeuchi; Kazuyoshi Takeda; Ko Okumura; Luc Van Kaer; H Okamura; S Akira; Kenji Nakanishi
Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5928-34.
2001: Luc Van Kaer
Drugs from the sea: a marine sponge-derived compound prevents Type 1 diabetes.
TheScientificWorldJournal 2001;1():630-2.
2001: Philip M Spence; Venkataraman Sriram; Luc Van Kaer; J A Hobbs; Randy R Brutkiewicz
Generation of cellular immunity to lymphocytic choriomeningitis virus is independent of CD1d1 expression.
Immunology 2001;104(2):168-74.
2001: Seokmann Hong; Michael T Wilson; Isao Serizawa; Lan Wu; Nagendra Singh; Olga V Naidenko; T Miura; T Haba; DC Scherer; J Wei; Mitchell Kronenberg; Yasuhiko Koezuka; Luc Van Kaer
The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice.
Nature medicine 2001;7(9):1052-6.
2001: Lonnie Lybarger; Yik Y L Yu; Taehoon Chun; Chyung-Ru Wang; Andres G Grandea; Luc Van Kaer; Ted H Hansen
Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2097-105.
2001: Taehoon Chun; Andres G Grandea; Lonnie Lybarger; James Forman; Luc Van Kaer; Chyung-Ru Wang
Functional roles of TAP and tapasin in the assembly of M3-N-formylated peptide complexes.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1507-14.
2001: Yoshihiro Hayakawa; Kazuyoshi Takeda; Hideo Yagita; S Kakuta; Y Iwakura; Luc Van Kaer; Ikuo Saiki; Ko Okumura
Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide.
European journal of immunology 2001;31(6):1720-7.
2001: Yoshihiro Hayakawa; Kazuyoshi Takeda; Hideo Yagita; Luc Van Kaer; Ikuo Saiki; Ko Okumura
Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6012-8.
2001: Andres G Grandea; Luc Van Kaer
Tapasin: an ER chaperone that controls MHC class I assembly with peptide.
Trends in immunology 2001;22(4):194-9.
2001: Maria C Leite-de-Moraes; A Hameg; M Pacilio; Yasuhiko Koezuka; M Taniguchi; Luc Van Kaer; Elke Schneider; Michel Dy; André Herbelin
IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):945-51.
2001: Luc Van Kaer
Accessory proteins that control the assembly of MHC molecules with peptides.
Immunologic research 2001;23(2-3):205-14.
2000: Gobardhan Das; DS Gould; M M Augustine; G Fragoso; E Sciutto; I Stroynowski; Luc Van Kaer; Daniel J Schust; Hidde L Ploegh; Charles A Janeway; E Scitto
Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes.
The Journal of experimental medicine 2000;192(10):1521-8.
2000: Andres G Grandea; Tatiana N Golovina; Sara E Hamilton; Venkataraman Sriram; Thomas Spies; Randy R Brutkiewicz; J T Harty; Laurence C Eisenlohr; Luc Van Kaer
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice.
Immunity 2000;13(2):213-22.
2000: J P Kovalik; Nagendra Singh; SK Mendiratta; WD Martin; Leszek Ignatowicz; Luc Van Kaer
The alloreactive and self-restricted CD4+ T cell response directed against a single MHC class II/peptide combination.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1285-93.
2000: Gloria Gonzalez-Aseguinolaza; C de Oliveira; M Tomaska; S Hong; Oscar Bruna-Romero; T Nakayama; M Taniguchi; Albert Bendelac; Luc Van Kaer; Yasuhiko Koezuka; Moriya Tsuji
alpha -galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8461-6.
2000: Alexandra O Sousa; RJ Mazzaccaro; Robert G Russell; Francis K Lee; O C Turner; S Hong; Luc Van Kaer; Barry R Bloom
Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4204-8.
1999: Seokmann Hong; Luc Van Kaer
Immune privilege: keeping an eye on natural killer T cells.
The Journal of experimental medicine 1999;190(9):1197-200.
1999: Nagendra Singh; Luc Van Kaer
Unexpected reactivities of T cells selected by a single MHC-peptide ligand.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3583-91.
1999: Nagendra Singh; Seokmann Hong; DC Scherer; Isao Serizawa; N Burdin; Mitchell Kronenberg; Yasuhiko Koezuka; Luc Van Kaer
Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2373-7.
1999: A Hameg; Christine Gouarin; Jean-Marc Gombert; S Hong; Luc Van Kaer; Jean-François Bach; André Herbelin
IL-7 up-regulates IL-4 production by splenic NK1.1+ and NK1.1- MHC class I-like/CD1-dependent CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7067-74.
1999: Seokmann Hong; DC Scherer; Nagendra Singh; SK Mendiratta; Isao Serizawa; Yasuhiko Koezuka; Luc Van Kaer
Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice.
Immunological reviews 1999;169():31-44.
1999: SK Mendiratta; J P Kovalik; Seokmann Hong; Nagendra Singh; WD Martin; Luc Van Kaer
Peptide dependency of alloreactive CD4+ T cell responses.
International immunology 1999;11(3):351-60.
1998: VM Dabhi; R Hovik; Luc Van Kaer; Kirsten Fischer Lindahl
The alloreactive T cell response against the class Ib molecule H2-M3 is specific for high affinity peptides.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5171-8.
1998: Jianhua Zhang; X Liu; D C Scherer; Luc Van Kaer; X Wang; Mingli Xu
Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12480-5.
1998: Kevin Swier; DR Brown; J J Bird; W D Martin; Luc Van Kaer; Steven L Reiner
A critical, invariant chain-independent role for H2-M in antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):540-4.
1997: Derek B Sant'Angelo; PG Waterbury; B E Cohen; W D Martin; Luc Van Kaer; Adrian C Hayday; Charles A Janeway
The imprint of intrathymic self-peptides on the mature T cell receptor repertoire.
Immunity 1997;7(4):517-24.
1997: SK Mendiratta; WD Martin; Seokmann Hong; Alina Boesteanu; Sebastian JOYCE; Luc Van Kaer
CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.
Immunity 1997;6(4):469-77.