Luc Van Kaer

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Das Jyoti; Ren Guangwen; Zhang Liying; Roberts Arthur I; Zhao Xin; Bothwell Alfred L M; Van Kaer Luc; Shi Yufang; Das Gobardhan
Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation.
Moore Martin L; Newcomb Dawn C; Parekh Vrajesh V; Van Kaer Luc; Collins Robert D; Zhou Weisong; Goleniewska Kasia; Chi Michael H; Mitchell Daphne; Boyce Joshua A; Durbin Joan E; Sturkie Carla; Peebles R Stokes
STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection.
Wu L; Gabriel C L; Parekh V V; Van Kaer L
Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities.

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All Publications

2009: Das Jyoti; Ren Guangwen; Zhang Liying; Roberts Arthur I; Zhao Xin; Bothwell Alfred L M; Van Kaer Luc; Shi Yufang; Das Gobardhan
Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation.
The Journal of experimental medicine 2009;206(11):2407-16.
2009: Moore Martin L; Newcomb Dawn C; Parekh Vrajesh V; Van Kaer Luc; Collins Robert D; Zhou Weisong; Goleniewska Kasia; Chi Michael H; Mitchell Daphne; Boyce Joshua A; Durbin Joan E; Sturkie Carla; Peebles R Stokes
STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):2016-26.
2009: Wu L; Gabriel C L; Parekh V V; Van Kaer L
Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities.
Tissue antigens 2009;73(6):535-45.
2009: Moens Leen; Jeurissen Axel; Nierkens Stefan; Boon Louis; Van Kaer Luc; Kasran Ahmad; Wuyts Greet; Ceuppens Jan L; Bossuyt Xavier
Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice.
Infection and immunity 2009;77(5):1976-80.
2009: Parekh Vrajesh V; Lalani Saif; Kim Sungjune; Halder Ramesh; Azuma Miyuki; Yagita Hideo; Kumar Vipin; Wu Lan; Kaer Luc Van
PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2816-26.
2009: Wu Lan; Van Kaer Luc
Natural killer T cells and autoimmune disease.
Current molecular medicine 2009;9(1):4-14.
2009: Sadagopal Shanmugalakshmi; Braunstein Miriam; Hager Cynthia C; Wei Jie; Daniel Alexandria K; Bochan Markian R; Crozier Ian; Smith Nathaniel E; Gates Hiriam O; Barnett Louise; Van Kaer Luc; Price James O; Blackwell Timothy S; Kalams Spyros A; Kernodle Douglas S
Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG.
PloS one 2009;4(5):e5531.
2008: Kim Sungjune; Lalani Saif; Parekh Vrajesh V; Wu Lan; Van Kaer Luc
Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants.
Expert review of vaccines 2008;7(10):1519-32.
2008: Cai Zheqing P; Shen Zhenyun; Van Kaer Luc; Becker Lewis C
Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(12):4248-57.
2008: Olivares-Villagómez Danyvid; Mendez-Fernandez Yanice V; Parekh Vrajesh V; Lalani Saif; Vincent Tiffaney L; Cheroutre Hilde; Van Kaer Luc
Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17931-6.
2008: Diao Hongyan; Iwabuchi Kazuya; Li Lanjuan; Onoe Kazunori; Van Kaer Luc; Kon Shigeyuki; Saito Yoshinari; Morimoto Junko; Denhardt David T; Rittling Susan; Uede Toshimitsu
Osteopontin regulates development and function of invariant natural killer T cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(41):15884-9.
2008: Adeeku Eric; Gudapati Prathyusha; Mendez-Fernandez Yanice; Van Kaer Luc; Boothby Mark
Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(27):9307-12.
2008: Joyce Sebastian; Van Kaer Luc
Lung NKT cell commotion takes your breath away.
Nature medicine 2008;14(6):609-10.
2008: Ni Chang-Yuan; Wu Zhao-Hui; Florence William C; Parekh Vrajesh V; Arrate Maria Pia; Pierce Steven; Schweitzer Brock; Van Kaer Luc; Joyce Sebastian; Miyamoto Shigeki; Ballard Dean W; Oltz Eugene M
Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7107-11.
2008: Kim Sungjune; Lalani Saif; Parekh Vrajesh V; Vincent Tiffaney L; Wu Lan; Van Kaer Luc
Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice.
The Journal of clinical investigation 2008;118(6):2301-15.
2008: Joyce Sebastian; Van Kaer Luc
Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile.
Cell host & microbe 2008;3(5):275-7.
2008: Yamaura Ayako; Hotta Chie; Nakazawa Masatoshi; Van Kaer Luc; Minami Mutsuhiko
Human invariant Valpha24+ natural killer T cells acquire regulatory functions by interacting with IL-10-treated dendritic cells.
Blood 2008;111(8):4254-63.
2008: Van Kaer Luc
Pillars article: antigen presentation: discovery of the peptide TAP.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2723-4.
2008: Matsumoto Yukie; Yuki Nobuhiro; Van Kaer Luc; Furukawa Koichi; Hirata Koichi; Sugita Masahiko
Cutting edge: Guillain-Barre syndrome-associated IgG responses to gangliosides are generated independently of CD1 function in mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):39-43.
2007: Wu Lan; Van Kaer Luc
Role of NKT cells in the digestive system. II. NKT cells and diabetes.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(5):G919-22.
2007: Medeiros Monica M; Peixoto Jaqueline R; Oliveira Ana-Carolina; Cardilo-Reis Larissa; Koatz Vera L G; Van Kaer Luc; Previato José O; Mendonça-Previato Lúcia; Nobrega Alberto; Bellio Maria
Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi.
Journal of leukocyte biology 2007;82(3):488-96.
2007: Puttaparthi Krishna; Van Kaer Luc; Elliott Jeffrey L
Assessing the role of immuno-proteasomes in a mouse model of familial ALS.
Experimental neurology 2007;206(1):53-8.
2007: Van Kaer Luc
NKT cells: T lymphocytes with innate effector functions.
Current opinion in immunology 2007;19(3):354-64.
2007: Yang Jun-Qi; Wen Xiangshu; Liu Hongzhu; Folayan Gbolahan; Dong Xin; Zhou Min; Van Kaer Luc; Singh Ram Raj
Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model.
Arthritis and rheumatism 2007;56(4):1219-33.
2007: Parekh Vrajesh V; Lalani Saif; Van Kaer Luc
The in vivo response of invariant natural killer T cells to glycolipid antigens.
International reviews of immunology 2007;26(1-2):31-48.
2006: Das Jyoti; Eynott Paul; Jupp Ray; Bothwell Alfred; Van Kaer Luc; Shi Yufang; Das Gobardhan
Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation.
Nature medicine 2006;12(12):1345-6; author reply 1347.
2006: Das Gobardhan; Das Jyoti; Eynott Paul; Zhang Yingyu; Bothwell Alfred L M; Van Kaer Luc; Shi Yufang
Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases.
The Journal of experimental medicine 2006;203(12):2603-11.
2006: Takagi Dai; Iwabuchi Kazuya; Maeda Masanori; Nakamaru Yuji; Furuta Yasushi; Fukuda Satoshi; Van Kaer Luc; Nishihira Jun; Onoé Kazunori
Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice.
International journal of molecular medicine 2006;18(5):829-36.
2006: Shi Fu-Dong; Van Kaer Luc
Reciprocal regulation between natural killer cells and autoreactive T cells.
Nature reviews. Immunology 2006;6(10):751-60.
2006: Bezbradica Jelena S; Gordy Laura E; Stanic Aleksandar K; Dragovic Srdjan; Hill Timothy; Hawiger Jacek; Unutmaz Derya; Van Kaer Luc; Joyce Sebastian
Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny.
Immunity 2006;25(3):487-97.
2006: Van Kaer Luc; Joyce Sebastian
Viral evasion of antigen presentation: not just for peptides anymore.
Nature immunology 2006;7(8):795-7.
2006: La Cava Antonio; Van Kaer Luc; Fu-Dong-Shi
CD4+CD25+ Tregs and NKT cells: regulators regulating regulators.
Trends in immunology 2006;27(7):322-7.
2006: Major Amy S; Joyce Sebastian; Van Kaer Luc
Lipid metabolism, atherogenesis and CD1-restricted antigen presentation.
Trends in molecular medicine 2006;12(6):270-8.
2006: Renukaradhya Gourapura J; Sriram Venkataraman; Du Wenjun; Gervay-Hague Jacquelyn; Van Kaer Luc; Brutkiewicz Randy R
Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo.
International journal of cancer. Journal international du cancer 2006;118(12):3045-53.
2006: Liu Ruolan; Van Kaer Luc; La Cava Antonio; Price Mary; Campagnolo Denise I; Collins Mary; Young Deborah A; Vollmer Timothy L; Shi Fu-Dong
Autoreactive T cells mediate NK cell degeneration in autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5247-54.
2006: Yan Jingbo; Parekh Vrajesh V; Mendez-Fernandez Yanice; Olivares-Villagómez Danyvid; Dragovic Srdjan; Hill Timothy; Roopenian Derry C; Joyce Sebastian; Van Kaer Luc
In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules.
The Journal of experimental medicine 2006;203(3):647-59.
2006: Eger Karla A; Sundrud Mark S; Motsinger Alison A; Tseng Michelle; Van Kaer Luc; Unutmaz Derya
Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions.
PloS one 2006;1():e50.
2006: Major Amy S; Singh Ram R; Joyce Sebastian; Van Kaer Luc
The role of invariant natural killer T cells in lupus and atherogenesis.
Immunologic research 2006;34(1):49-66.
2005: Liu Ruolan; La Cava Antonio; Bai Xue-Feng; Jee Youngheun; Price Mary; Campagnolo Denise I; Christadoss Premkumar; Vollmer Timothy L; Van Kaer Luc; Shi Fu-Dong
Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):7898-904.
2005: Beilke Joshua N; Kuhl Nathan R; Van Kaer Luc; Gill Ronald G
NK cells promote islet allograft tolerance via a perforin-dependent mechanism.
Nature medicine 2005;11(10):1059-65.
2005: Parekh Vrajesh V; Wilson Michael T; Olivares-Villagómez Danyvid; Singh Avneesh K; Wu Lan; Wang Chyung-Ru; Joyce Sebastian; Van Kaer Luc
Glycolipid antigen induces long-term natural killer T cell anergy in mice.
The Journal of clinical investigation 2005;115(9):2572-83.
2005: Chen Ming; Tabaczewski Piotr; Truscott Steven M; Van Kaer Luc; Stroynowski Iwona
Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):1047-55.
2005: Van Kaer Luc; Joyce Sebastian
Innate immunity: NKT cells in the spotlight.
Current biology : CB 2005;15(11):R429-31.
2005: Bezbradica Jelena S; Stanic Aleksandar K; Matsuki Naoto; Bour-Jordan Helene; Bluestone Jeffrey A; Thomas James W; Unutmaz Derya; Van Kaer Luc; Joyce Sebastian
Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4696-705.
2005: Bezbradica Jelena S; Hill Timothy; Stanic Aleksandar K; Van Kaer Luc; Joyce Sebastian
Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):5114-9.
2005: Singh Avneesh K; Yang Jun-Qi; Parekh Vrajesh V; Wei Jie; Wang Chyung-Ru; Joyce Sebastian; Singh Ram R; Van Kaer Luc
The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in mice.
European journal of immunology 2005;35(4):1143-54.
2005: Robbins Scott H; Tessmer Marlowe S; Van Kaer Luc; Brossay Laurent
Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation.
European journal of immunology 2005;35(3):757-65.
2005: Van Kaer Luc
alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles.
Nature reviews. Immunology 2005;5(1):31-42.
2005: Hashimoto Daigo; Asakura Shoji; Miyake Sachiko; Yamamura Takashi; Van Kaer Luc; Liu Chen; Tanimoto Mitsune; Teshima Takanori
Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):551-6.
2005: Parekh Vrajesh V; Wilson Michael T; Van Kaer Luc
iNKT-cell responses to glycolipids.
Critical reviews in immunology 2005;25(3):183-213.
2004: Major Amy S; Wilson Michael T; McCaleb Jennifer L; Ru Su Yan; Stanic Aleksandar K; Joyce Sebastian; Van Kaer Luc; Fazio Sergio; Linton Macrae F
Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(12):2351-7.
2004: Diao Hongyan; Kon Shigeyuki; Iwabuchi Kazuya; Kimura Chiemi; Morimoto Junko; Ito Daisuke; Segawa Tatsuya; Maeda Masahiro; Hamuro Junji; Nakayama Toshinori; Taniguchi Masaru; Yagita Hideo; Van Kaer Luc; Onóe Kazunori; Denhardt David; Rittling Susan; Uede Toshimitsu
Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.
Immunity 2004;21(4):539-50.
2004: Nakai Yukihito; Iwabuchi Kazuya; Fujii Satoshi; Ishimori Naoki; Dashtsoodol Nyambayar; Watano Keiko; Mishima Tetsuya; Iwabuchi Chikako; Tanaka Shinya; Bezbradica Jelena S; Nakayama Toshinori; Taniguchi Masaru; Miyake Sachiko; Yamamura Takashi; Kitabatake Akira; Joyce Sebastian; Van Kaer Luc; Onoé Kazunori
Natural killer T cells accelerate atherogenesis in mice.
Blood 2004;104(7):2051-9.
2004: Li LiQi; Sullivan Barbara A; Aldrich Carla J; Soloski Mark J; Forman James; Grandea Andres G; Jensen Peter E; Van Kaer Luc
Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3707-15.
2004: Parekh Vrajesh V; Singh Avneesh K; Wilson Michael T; Olivares-Villagómez Danyvid; Bezbradica Jelena S; Inazawa Hiroko; Ehara Hiromi; Sakai Teruyuki; Serizawa Isao; Wu Lan; Wang Chyung-Ru; Joyce Sebastian; Van Kaer Luc
Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3693-706.
2004: Van Kaer Luc
Natural killer T cells as targets for immunotherapy of autoimmune diseases.
Immunology and cell biology 2004;82(3):315-22.
2004: Yang Jun-Qi; Chun Taehoon; Liu Hongzhu; Hong Seokmann; Bui Hai; Van Kaer Luc; Wang Chyung-Ru; Singh Ram Raj
CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice.
European journal of immunology 2004;34(6):1723-32.
2004: Adachi Keishi; Tsutsui Hiroko; Seki Ekihiro; Nakano Hiroki; Takeda Kazuyoshi; Okumura Ko; Van Kaer Luc; Nakanishi Kenji
Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice.
International immunology 2004;16(6):787-98.
2004: Stanic Aleksandar K; Bezbradica Jelena S; Park Jang-June; Van Kaer Luc; Boothby Mark R; Joyce Sebastian
Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4667-71.
2004: Godfrey Dale I; MacDonald H Robson; Kronenberg Mitchell; Smyth Mark J; Van Kaer Luc
NKT cells: what's in a name?
Nature reviews. Immunology 2004;4(3):231-7.
2004: Roberts Tonya J; Lin Yinling; Spence Philip M; Van Kaer Luc; Brutkiewicz Randy R
CD1d1-dependent control of the magnitude of an acute antiviral immune response.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3454-61.
2004: Mühlen Katrin A; Schümann Jens; Wittke Frederick; Stenger Steffen; Van Rooijen Nico; Van Kaer Luc; Tiegs Gisa
NK cells, but not NKT cells, are involved in Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):3034-41.
2004: Turnquist Heth R; Petersen Jason L; Vargas Shanna E; McIlhaney Mary M; Bedows Elliott; Mayer Werner E; Grandea Andres G; Van Kaer Luc; Solheim Joyce C
The Ig-like domain of tapasin influences intermolecular interactions.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):2976-84.
2004: Stanic Aleksandar K; Bezbradica Jelena S; Park Jang-June; Matsuki Naoto; Mora Ana L; Van Kaer Luc; Boothby Mark R; Joyce Sebastian
NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2265-73.
2004: Van Kaer Luc
Regulation of immune responses by CD1d-restricted natural killer T cells.
Immunologic research 2004;30(2):139-53.
2003: Zhang Jianhua; Dong Mei; Li Lily; Fan Yunxia; Pathre Purnima; Dong Jin; Lou Danwen; Wells James M; Olivares-Villagómez Danyvid; Van Kaer Luc; Wang Xiaodong; Xu Ming
Endonuclease G is required for early embryogenesis and normal apoptosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15782-7.
2003: Liang Haobo; VanValkenburgh Clint; Chen Xuemin; Mullins Chris; Van Kaer Luc; Green Neil; Fang Hong
Genetic complementation in yeast reveals functional similarities between the catalytic subunits of mammalian signal peptidase complex.
The Journal of biological chemistry 2003;278(51):50932-9.
2003: Zhang Feng; Liang Zhiyan; Matsuki Naoto; Van Kaer Luc; Joyce Sebastian; Wakeland Edward K; Aune Thomas M
A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4613-20.
2003: Stanic Aleksandar K; Shashidharamurthy R; Bezbradica Jelena S; Matsuki Naoto; Yoshimura Yoshitaka; Miyake Sachiko; Choi Eun Young; Schell Todd D; Van Kaer Luc; Tevethia Satvir S; Roopenian Derry C; Yamamura Takashi; Joyce Sebastian
Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected].
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4539-51.
2003: Yang Jun-Qi; Saxena Vijay; Xu Honglin; Van Kaer Luc; Wang Chyung-Ru; Singh Ram Raj
Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4439-46.
2003: Wilson Michael T; Johansson Cecilia; Olivares-Villagómez Danyvid; Singh Avneesh K; Stanic Aleksandar K; Wang Chyung-Ru; Joyce Sebastian; Wick Mary Jo; Van Kaer Luc
The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10913-8.
2003: Yang Jun-Qi; Singh Avneesh K; Wilson Michael T; Satoh Minoru; Stanic Aleksandar K; Park Jang-June; Hong Seokmann; Gadola Stephan D; Mizutani Akiei; Kakumanu Srinivasa R; Reeves Westley H; Cerundolo Vincenzo; Joyce Sebastian; Van Kaer Luc; Singh Ram Raj
Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):2142-53.
2003: Shao Hui; Van Kaer Luc; Sun Sheher L; Kaplan Henry J; Sun Deming
Infiltration of the inflamed eye by NKT cells in a rat model of experimental autoimmune uveitis.
Journal of autoimmunity 2003;21(1):37-45.
2003: Motsinger Alison; Azimzadeh Agnes; Stanic Aleksandar K; Johnson R Paul; Van Kaer Luc; Joyce Sebastian; Unutmaz Derya
Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells.
Journal of virology 2003;77(14):8153-8.
2003: Chefalo Peter J; Grandea Andres G; Van Kaer Luc; Harding Clifford V
Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(12):5825-33.
2003: Matsuki Naoto; Stanic Aleksandar K; Embers Monica E; Van Kaer Luc; Morel Laurence; Joyce Sebastian
Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5429-37.
2003: Yoshimoto Tomohiro; Min Booki; Sugimoto Takaaki; Hayashi Nobuki; Ishikawa Yuriko; Sasaki Yuki; Hata Hitomi; Takeda Kazuyoshi; Okumura Ko; Van Kaer Luc; Paul William E; Nakanishi Kenji
Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice.
The Journal of experimental medicine 2003;197(8):997-1005.
2003: Stanic Aleksandar K; De Silva A Dharshan; Park Jang-June; Sriram Venkataraman; Ichikawa Shinichi; Hirabyashi Yoshio; Hayakawa Kyoko; Van Kaer Luc; Brutkiewicz Randy R; Joyce Sebastian
Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1849-54.
2003: Joyce Sebastian; Van Kaer Luc
CD1-restricted antigen presentation: an oily matter.
Current opinion in immunology 2003;15(1):95-104.
2002: Hayakawa Yoshihiro; Takeda Kazuyoshi; Yagita Hideo; Smyth Mark J; Van Kaer Luc; Okumura Ko; Saiki Ikuo
IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide.
Blood 2002;100(5):1728-33.
2002: Faveeuw Christelle; Angeli Véronique; Fontaine Josette; Maliszewski Charles; Capron André; Van Kaer Luc; Moser Muriel; Capron Monique; Trottein François
Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):906-12.
2002: Mars Lennart T; Laloux Véronique; Goude Karine; Desbois Sabine; Saoudi Abdelhadi; Van Kaer Luc; Lassmann Hans; Herbelin André; Lehuen Agnès; Liblau Roland S
Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6007-11.
2002: Suárez Idania Marrero; Benvenutti Luiz Alberto; Noronh Irene; Van Kaer Luc; Kalil Jorge; Coelho Veronica
Rejection of grafts with no H-2 disparity in TAP1 mutant mice: CD4 T cells are important effector cells and self H-2b class I molecules are target.
Transplant immunology 2002;9(2-4):101-10.
2002: Wilson Michael T; Singh Avneesh K; Van Kaer Luc
Immunotherapy with ligands of natural killer T cells.
Trends in molecular medicine 2002;8(5):225-31.
2002: Johnson Teresa R; Hong Seokmann; Van Kaer Luc; Koezuka Yasuhiko; Graham Barney S
NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus.
Journal of virology 2002;76(9):4294-303.
2002: Tompkins Stephen Mark; Padilla Josette; Dal Canto Mauro C; Ting Jenny P-Y; Van Kaer Luc; Miller Stephen D
De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):4173-83.
2002: Motsinger Alison; Haas David W; Stanic Aleksandar K; Van Kaer Luc; Joyce Sebastian; Unutmaz Derya
CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection.
The Journal of experimental medicine 2002;195(7):869-79.
2002: Gonzalez-Aseguinolaza Gloria; Van Kaer Luc; Bergmann Cornelia C; Wilson James M; Schmieg John; Kronenberg Mitchell; Nakayama Toshinori; Taniguchi Masaru; Koezuka Yasuhiko; Tsuji Moriya
Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines.
The Journal of experimental medicine 2002;195(5):617-24.
2002: Mempel Martin; Ronet Catherine; Suarez Felipe; Gilleron Martine; Puzo Germain; Van Kaer Luc; Lehuen Agnès; Kourilsky Philippe; Gachelin Gabriel
Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):365-71.
2001: Singh A K; Wilson M T; Hong S; Olivares-Villagómez D; Du C; Stanic A K; Joyce S; Sriram S; Koezuka Y; Van Kaer L
Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2001;194(12):1801-11.
2001: Van Kaer L
Drugs from the sea: a marine sponge-derived compound prevents Type 1 diabetes.
TheScientificWorldJournal 2001;1():630-2.
2001: Adachi K; Tsutsui H; Kashiwamura S; Seki E; Nakano H; Takeuchi O; Takeda K; Okumura K; Van Kaer L; Okamura H; Akira S; Nakanishi K
Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5928-34.
2001: Spence P M; Sriram V; Van Kaer L; Hobbs J A; Brutkiewicz R R
Generation of cellular immunity to lymphocytic choriomeningitis virus is independent of CD1d1 expression.
Immunology 2001;104(2):168-74.
2001: Hong S; Wilson M T; Serizawa I; Wu L; Singh N; Naidenko O V; Miura T; Haba T; Scherer D C; Wei J; Kronenberg M; Koezuka Y; Van Kaer L
The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice.
Nature medicine 2001;7(9):1052-6.
2001: Lybarger L; Yu Y Y; Chun T; Wang C R; Grandea A G; Van Kaer L; Hansen T H
Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2097-105.
2001: Chun T; Grandea A G; Lybarger L; Forman J; Van Kaer L; Wang C R
Functional roles of TAP and tapasin in the assembly of M3-N-formylated peptide complexes.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1507-14.
2001: Hayakawa Y; Takeda K; Yagita H; Kakuta S; Iwakura Y; Van Kaer L; Saiki I; Okumura K
Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide.
European journal of immunology 2001;31(6):1720-7.
2001: Hayakawa Y; Takeda K; Yagita H; Van Kaer L; Saiki I; Okumura K
Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6012-8.
2001: Grandea A G; Van Kaer L
Tapasin: an ER chaperone that controls MHC class I assembly with peptide.
Trends in immunology 2001;22(4):194-9.
2001: Leite-De-Moraes M C; Hameg A; Pacilio M; Koezuka Y; Taniguchi M; Van Kaer L; Schneider E; Dy M; Herbelin A
IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):945-51.
2001: Van Kaer L
Accessory proteins that control the assembly of MHC molecules with peptides.
Immunologic research 2001;23(2-3):205-14.
2000: Das G; Gould D S; Augustine M M; Fragoso G; Sciutto E; Stroynowski I; Van Kaer L; Schust D J; Ploegh H; Janeway C A;
Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes.
The Journal of experimental medicine 2000;192(10):1521-8.
2000: Grandea A G; Golovina T N; Hamilton S E; Sriram V; Spies T; Brutkiewicz R R; Harty J T; Eisenlohr L C; Van Kaer L
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice.
Immunity 2000;13(2):213-22.
2000: Kovalik J P; Singh N; Mendiratta S K; Martin W D; Ignatowicz L; Van Kaer L
The alloreactive and self-restricted CD4+ T cell response directed against a single MHC class II/peptide combination.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1285-93.
2000: Gonzalez-Aseguinolaza G; de Oliveira C; Tomaska M; Hong S; Bruna-Romero O; Nakayama T; Taniguchi M; Bendelac A; Van Kaer L; Koezuka Y; Tsuji M
alpha -galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8461-6.
2000: Sousa A O; Mazzaccaro R J; Russell R G; Lee F K; Turner O C; Hong S; Van Kaer L; Bloom B R
Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4204-8.
1999: Hong S; Van Kaer L
Immune privilege: keeping an eye on natural killer T cells.
The Journal of experimental medicine 1999;190(9):1197-200.
1999: Singh N; Van Kaer L
Unexpected reactivities of T cells selected by a single MHC-peptide ligand.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3583-91.
1999: Singh N; Hong S; Scherer D C; Serizawa I; Burdin N; Kronenberg M; Koezuka Y; Van Kaer L
Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2373-7.
1999: Hong S; Scherer D C; Singh N; Mendiratta S K; Serizawa I; Koezuka Y; Van Kaer L
Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice.
Immunological reviews 1999;169():31-44.
1999: Hameg A; Gouarin C; Gombert J M; Hong S; Van Kaer L; Bach J F; Herbelin A
IL-7 up-regulates IL-4 production by splenic NK1.1+ and NK1.1- MHC class I-like/CD1-dependent CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7067-74.
1999: Mendiratta S K; Kovalik J P; Hong S; Singh N; Martin W D; Van Kaer L
Peptide dependency of alloreactive CD4+ T cell responses.
International immunology 1999;11(3):351-60.
1998: Dabhi V M; Hovik R; Van Kaer L; Lindahl K F
The alloreactive T cell response against the class Ib molecule H2-M3 is specific for high affinity peptides.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5171-8.
1998: Zhang J; Liu X; Scherer D C; van Kaer L; Wang X; Xu M
Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12480-5.
1998: Swier K; Brown D R; Bird J J; Martin W D; Van Kaer L; Reiner S L
A critical, invariant chain-independent role for H2-M in antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):540-4.
1997: Sant'Angelo D B; Waterbury P G; Cohen B E; Martin W D; Van Kaer L; Hayday A C; Janeway C A
The imprint of intrathymic self-peptides on the mature T cell receptor repertoire.
Immunity 1997;7(4):517-24.
1997: Mendiratta S K; Martin W D; Hong S; Boesteanu A; Joyce S; Van Kaer L
CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.
Immunity 1997;6(4):469-77.

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