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Vassiliki Boussiotis

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Nikolaos Patsoukis; Duygu Sari; Vassiliki A Boussiotis
PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A.
Joseph P Wynne; Wenjuan Su; Jinhua Wu; Vassiliki A Boussiotis; Stevan R Hubbard; Adam Mor; Nikolaos Patsoukis; Mark R Philips
Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector.
Nikolaos Patsoukis; Victoria Petkova; Julia Brown; Lequn Li; Fang Liu; Vassiliki A Boussiotis
Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation.

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All Publications

2012: Nikolaos Patsoukis; Duygu Sari; Vassiliki A Boussiotis
PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A.
Cell cycle (Georgetown, Tex.) 2012;11(23):4305-9.
2012: Joseph P Wynne; Wenjuan Su; Jinhua Wu; Vassiliki A Boussiotis; Stevan R Hubbard; Adam Mor; Nikolaos Patsoukis; Mark R Philips
Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector.
The Journal of cell biology 2012;199(2):317-30.
2012: Nikolaos Patsoukis; Victoria Petkova; Julia Brown; Lequn Li; Fang Liu; Vassiliki A Boussiotis
Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation.
Science signaling 2012;5(230):ra46.
2012: Lequn Li; Nikolaos Patsoukis; Victoria Petkova; Vassiliki A Boussiotis
Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells.
PloS one 2012;7(9):e45115.
2011: Lequn Li; Vassiliki A Boussiotis
Molecular and functional heterogeneity of T regulatory cells.
Clinical immunology (Orlando, Fla.) 2011;141(3):244-52.
2011: Pablo Hernández-Varas; Georgina P Coló; Rubén A Bartolomé; Andrew Paterson; Iria Medraño-Fernández; Nohemí Arellano-Sánchez; Carlos Cabañas; Paloma Sánchez-Mateos; Esther M Lafuente; Vassiliki A Boussiotis; Staffan Strömblad; Joaquin Teixidó
Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells.
The Journal of biological chemistry 2011;286(21):18492-504.
2011: Corey Cutler; K Stevenson; Haesook T Kim; J Brown; S McDonough; M Herrera; C Reynolds; Deborah Liney; Grace S Kao; Vincent T Ho; Philippe Armand; John Koreth; Edwin P Alyea; Bimalangshu R Dey; Eyal C Attar; Thomas R Spitzer; Vassiliki A Boussiotis; Jerome Ritz; Robert J Soiffer; Joseph H Antin; Karen K Ballen
Double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis.
Bone marrow transplantation 2011;46(5):659-67.
2010: Lequn Li; Jin Kim; Vassiliki A Boussiotis
IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):4148-53.
2010: Jacalyn Rosenblatt; A Bissonnette; R Ahmad; Zekui Wu; Baldev Vasir; K Stevenson; C Zarwan; W Keefe; B Glotzbecker; H Mills; Robin M Joyce; J D Levine; Dimitrios Tzachanis; Vassiliki A Boussiotis; Donald Kufe; David Avigan
Immunomodulatory effects of vitamin D: implications for GVHD.
Bone marrow transplantation 2010;45(9):1463-8.
2010: Julia A Brown; Kristen Stevenson; Haesook T Kim; Corey Cutler; Karen Ballen; Sean McDonough; Carol Reynolds; Maria Herrera; Deborah Liney; Vincent T Ho; Grace Kao; Philippe Armand; John Koreth; Edwin P Alyea; Steve McAfee; Eyal Attar; Bimalangshu R Dey; Thomas Spitzer; Robert J Soiffer; Jerome Ritz; Joseph H Antin; Vassiliki A Boussiotis
Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis.
Blood 2010;115(20):4111-9.
2010: Jacalyn Rosenblatt; Zekui Wu; Baldev Vasir; Corrine Zarwan; Richard Stone; Heidi Mills; Thea Friedman; Panagiotis A Konstantinopoulos; Dimitrios Spentzos; Musie Ghebremichael; Kristen Stevenson; Donna Neuberg; James D Levine; Robin Joyce; Dimitrios Tzachanis; Vassiliki A Boussiotis; Donald Kufe; David Avigan
Generation of tumor-specific T lymphocytes using dendritic cell/tumor fusions and anti-CD3/CD28.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2010;33(2):155-66.
2010: Lequn Li; Jin sub Kim; Vassiliki A Boussiotis
Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms.
Cellular immunology 2010;266(1):7-13.
2009: Lequn Li; Hui Wang; Jin sub Kim; German Pihan; Vassiliki A Boussiotis
The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD.
Cell cycle (Georgetown, Tex.) 2009;8(11):1794 - 1802.
2009: Dimitrios Tzachanis; Vassiliki A Boussiotis
Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression.
Cell cycle (Georgetown, Tex.) 2009;8(7):1019-25.
2009: Nikolaos Patsoukis; Esther M Lafuente; Paul Meraner; Jin sub Kim; David Dombkowski; Lequn Li; Vassiliki A Boussiotis
RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells.
Science signaling 2009;2(99):ra79.
2008: Dawang Zhou; Benjamin D Medoff; Lanfen Chen; Lequn Li; Xian-feng Zhang; Maria Praskova; Matthew Liu; Aimee Landry; Richard S Blumberg; Vassiliki A Boussiotis; Ramnik Xavier; Joseph Avruch
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(51):20321-6.
2008: Naohide Watanabe; Laurent Bodin; Manjula Pandey; Matthias Krause; Shaun Coughlin; Vassiliki A Boussiotis; Mark H Ginsberg; Sanford J Shattil
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3.
The Journal of cell biology 2008;181(7):1211-22.
2008: Julia A Brown; Vassiliki A Boussiotis
Umbilical cord blood transplantation: basic biology and clinical challenges to immune reconstitution.
Clinical immunology (Orlando, Fla.) 2008;127(3):286-97.
2008: Xupeng Ge; Julia Brown; Megan Sykes; Vassiliki A Boussiotis
CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008;14(5):518-30.
2008: Lequn Li; Vassiliki A Boussiotis
Control and regulation of peripheral tolerance in allergic inflammatory disease: therapeutic consequences.
Chemical immunology and allergy 2008;94():178-88.
2007: Esther M Lafuente; Yoshiko Iwamoto; Christopher V Carman; Andre A F L van Puijenbroek; Erica Constantine; Lequn Li; Vassiliki A Boussiotis
Active Rap1, a small GTPase that induces malignant transformation of hematopoietic progenitors, localizes in the nucleus and regulates protein expression.
Leukemia & lymphoma 2007;48(5):987-1002.
2007: Matthew J O'Shaughnessy; Zong-Ming Chen; Irene Gramaglia; Patricia A Taylor; Angela Panoskaltsis-Mortari; Christine Vogtenhuber; Ed Palmer; Thomas Grader-Beck; Vassiliki A Boussiotis; Bruce R Blazar
Elevation of intracellular cyclic AMP in alloreactive CD4(+) T Cells induces alloantigen-specific tolerance that can prevent GVHD lethality in vivo.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(5):530-42.
2007: Dimitrios Tzachanis; Lequn Li; Esther M Lafuente; Alla Berezovskaya; Gordon J Freeman; Vassiliki A Boussiotis
Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes.
Blood 2007;109(7):2944-52.
2006: Lequn Li; Yoshiko Iwamoto; Alla Berezovskaya; Vassiliki A Boussiotis
A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance.
Nature immunology 2006;7(11):1157-65.
2006: Lequn Li; Vassiliki A Boussiotis
Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications.
Journal of molecular medicine (Berlin, Germany) 2006;84(11):887-99.
2006: Jaewon Han; Chinten James Lim; Naohide Watanabe; Alessandra Soriani; Boris Ratnikov; David A Calderwood; Wilma Puzon-McLaughlin; Esther M Lafuente; Vassiliki A Boussiotis; Sanford J Shattil; Mark H Ginsberg
Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.
Current biology : CB 2006;16(18):1796-806.
2006: Leonard J Appleman; Irina Chernova; Lequn Li; Vassiliki A Boussiotis
CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFSkp2 ubiquitin ligase that leads p27kip1 to degradation.
Cell cycle (Georgetown, Tex.) 2006;5(18):2123-9.
2006: Esther Lafuente; Vassiliki A Boussiotis
Rap1 regulation of RIAM and cell adhesion.
Methods in enzymology 2006;407():345-58.
2005: Lequn Li; Wayne Godfrey; Stephen B Porter; Ying Ge; Carle H June; Bruce R Blazar; Vassiliki A Boussiotis
CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy.
Blood 2005;106(9):3068-73.
2005: Lequn Li; Rebecca J Greenwald; Esther M Lafuente; Dimitrios Tzachanis; Alla Berezovskaya; Gordon J Freeman; Arlene H Sharpe; Vassiliki A Boussiotis
Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3133-9.
2005: Joao T Barata; Angelo A Cardoso; Vassiliki A Boussiotis
Interleukin-7 in T-cell acute lymphoblastic leukemia: an extrinsic factor supporting leukemogenesis?
Leukemia & lymphoma 2005;46(4):483-95.
2005: Leonard J Appleman; Vassiliki A Boussiotis
In vitro models of human T cell anergy.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2005;Chapter 7():Unit 7.36.
2005: Theodoros P Vassilakopoulos; Maria K Angelopoulou; Nikos Constantinou; Themis Karmiris; Panagiotis Repoussis; Paraskevi Roussou; Marina P Siakantaris; Penelope Korkolopoulou; Marie-Christine Kyrtsonis; Styliani Kokoris; Maria N Dimopoulou; Eleni Variamis; Nora Viniou; Kostas Konstantopoulos; Evangelia M Dimitriadou; Athina Androulaki; Efstratios Patsouris; Ipatia Doussis-Anagnostopoulou; Panayiotis Panayiotidis; Vassiliki A Boussiotis; Christos Kittas; Gerassimos A Pangalis
Development and validation of a clinical prediction rule for bone marrow involvement in patients with Hodgkin lymphoma.
Blood 2005;105(5):1875-80.
2004: Joao T Barata; Thomas D Keenan; Ana Silva; Lee M Nadler; Vassiliki A Boussiotis; Angelo A Cardoso
Common gamma chain-signaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia.
Haematologica 2004;89(12):1459-67.
2004: Esther M Lafuente; Andre A F L van Puijenbroek; Matthias Krause; Christopher V Carman; Gordon J Freeman; Alla Berezovskaya; Erica Constantine; Timothy A Springer; Frank B Gertler; Vassiliki A Boussiotis
RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.
Developmental cell 2004;7(4):585-95.
2004: Matthias Krause; Jonathan D Leslie; Mary Stewart; Esther M Lafuente; Ferran Valderrama; Radhika Jagannathan; Geraldine A Strasser; Douglas A Rubinson; Hui Liu; Michael Way; Michael B Yaffe; Vassiliki A Boussiotis; Frank B Gertler
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.
Developmental cell 2004;7(4):571-83.
2004: Dimitrios Tzachanis; Esther M Lafuente; Lequn Li; Vassiliki A Boussiotis
Intrinsic and extrinsic regulation of T lymphocyte quiescence.
Leukemia & lymphoma 2004;45(10):1959-67.
2004: Joao T Barata; Ana Silva; Joana G Brandao; Lee M Nadler; Angelo A Cardoso; Vassiliki A Boussiotis
Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells.
The Journal of experimental medicine 2004;200(5):659-69.
2004: Theodoros P Vassilakopoulos; Maria K Angelopoulou; Marina P Siakantaris; Flora N Kontopidou; Maria N Dimopoulou; Styliani Kokoris; Marie-Christine Kyrtsonis; Panayiotis Tsaftaridis; Christos Karkantaris; Konstantinos Anargyrou; Dimitrios E Boutsis; Eleni Variamis; Thymios Michalopoulos; Vassiliki A Boussiotis; Panayiotis Panayiotidis; Constantinos Papavassiliou; Gerassimos A Pangalis
Combination chemotherapy plus low-dose involved-field radiotherapy for early clinical stage Hodgkin's lymphoma.
International journal of radiation oncology, biology, physics 2004;59(3):765-81.
2004: Joao T Barata; Vassiliki A Boussiotis; Jose A Yunes; Adolfo Ferrando; Lisa A Moreau; J Pedro Veiga; Stephen E Sallan; A Thomas Look; Lee M Nadler; Angelo A Cardoso
IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.
Blood 2004;103(5):1891-900.
2003: Dimitrios Tzachanis; Leonard J Appleman; Andre A F L van Puijenbroek; Alla Berezovskaya; Lee M Nadler; Vassiliki A Boussiotis
Differential localization and function of ADP-ribosylation factor-6 in anergic human T cells: a potential marker for their identification.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1691-6.
2003: Leonard J Appleman; Vassiliki A Boussiotis
T cell anergy and costimulation.
Immunological reviews 2003;192():161-80.
2003: Thomas Grader-Beck; Andre A F L van Puijenbroek; Lee M Nadler; Vassiliki A Boussiotis
cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression.
Blood 2003;101(3):998-1006.
2002: Leonard J Appleman; Dimitrios Tzachanis; Thomas Grader-Beck; Andre A F L van Puijenbroek; Vassiliki A Boussiotis
Induction of immunologic tolerance for allogeneic hematopoietic cell transplantation.
Leukemia & lymphoma 2002;43(6):1159-67.
2002: Julio C Delgado; Eunice Y Tsai; Sok Thim; Andres Baena; Vassiliki A Boussiotis; Jean-Marc Reynes; Sun Sath; Pierre Grosjean; Edmond J Yunis; Anne E Goldfeld
Antigen-specific and persistent tuberculin anergy in a cohort of pulmonary tuberculosis patients from rural Cambodia.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7576-81.
2002: Leonard J Appleman; Andre A F L van Puijenbroek; Kirstin M Shu; Lee M Nadler; Vassiliki A Boussiotis
CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2729-36.
2002: Dimitrios Tzachanis; Alla Berezovskaya; Lee M Nadler; Vassiliki A Boussiotis
Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses.
Blood 2002;99(4):1465-73.
2002: Rebecca J Greenwald; Mariette A Oosterwegel; Diane Van der Woude; Anup Kubal; Didier A Mandelbrot; Vassiliki A Boussiotis; Arlene H Sharpe
CTLA-4 regulates cell cycle progression during a primary immune response.
European journal of immunology 2002;32(2):366-73.
2001: Marie-Christine Kyrtsonis; Theodoros P Vassilakopoulos; Maria K Angelopoulou; P Siakantaris; Flora N Kontopidou; Maria N Dimopoulou; Vassiliki A Boussiotis; A Gribabis; Kostas Konstantopoulos; George Vaiopoulos; Phaedon Fessas; Christos Kittas; Gerassimos A Pangalis
Waldenström's macroglobulinemia: clinical course and prognostic factors in 60 patients. Experience from a single hematology unit.
Annals of hematology 2001;80(12):722-7.
2001: Dimitrios Tzachanis; Gordon J Freeman; Naoto Hirano; Andre A F L van Puijenbroek; M W Delfs; Alla Berezovskaya; Lee M Nadler; Vassiliki A Boussiotis
Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells.
Nature immunology 2001;2(12):1174-82.
2001: Theodoros P Vassilakopoulos; Maria K Angelopoulou; Marina P Siakantaris; Flora N Kontopidou; Maria N Dimopoulou; A Barbounis; V Grigorakis; Christos Karkantaris; Konstantinos Anargyrou; M Chatziioannou; John Rombos; Vassiliki A Boussiotis; George Vaiopoulos; Christos Kittas; Gerassimos A Pangalis
Prognostic factors in advanced stage Hodgkin's lymphoma: the significance of the number of involved anatomic sites.
European journal of haematology 2001;67(5-6):279-88.
2001: Joao T Barata; Angelo A Cardoso; Lee M Nadler; Vassiliki A Boussiotis
Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).
Blood 2001;98(5):1524-31.
2001: Yvette E Latchman; Clive R Wood; Tatyana Chernova; Divya Chaudhary; M Borde; Irina Chernova; Yoshiko Iwai; AJ Long; Julia A Brown; R Nunes; Edward Greenfield; K Bourque; Vassiliki A Boussiotis; Laura L Carter; Beatriz M Carreno; N Malenkovich; H Nishimura; T Okazaki; Tasuku Honjo; Arlene H Sharpe; Gordon J Freeman
PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
Nature immunology 2001;2(3):261-8.
2001: Rebecca J Greenwald; Vassiliki A Boussiotis; RB Lorsbach; Abul K Abbas; Arlene H Sharpe
CTLA-4 regulates induction of anergy in vivo.
Immunity 2001;14(2):145-55.
2001: Vassiliki A Boussiotis; Z M Chen; J C Zeller; William Murphy; Alla Berezovskaya; S Narula; M G Roncarolo; B R Blazar
Altered T-cell receptor + CD28-mediated signaling and blocked cell cycle progression in interleukin 10 and transforming growth factor-beta-treated alloreactive T cells that do not induce graft-versus-host disease.
Blood 2001;97(2):565-71.
2001: Leonard J Appleman; Dimitrios Tzachanis; Thomas Grader-Beck; Andre A F L van Puijenbroek; Vassiliki A Boussiotis
Helper T cell anergy: from biochemistry to cancer pathophysiology and therapeutics.
Journal of molecular medicine (Berlin, Germany) 2001;78(12):673-83.
2000: Alexander J McAdam; Tammy T Chang; A E Lumelsky; Edward Greenfield; Vassiliki A Boussiotis; Jonathan S Duke-Cohan; Tatyana Chernova; N Malenkovich; Claudia Jabs; Vijay K Kuchroo; Vincent Ling; Mary Collins; Arlene H Sharpe; Gordon J Freeman
Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5035-40.
2000: Vassiliki A Boussiotis; Eunice Y Tsai; Edmond J Yunis; Sok Thim; Julio C Delgado; Christopher Dascher; Alla Berezovskaya; Dominique Rousset; Jean-Marc Reynes; Anne E Goldfeld
IL-10-producing T cells suppress immune responses in anergic tuberculosis patients.
The Journal of clinical investigation 2000;105(9):1317-25.
2000: Maria K Angelopoulou; Theodoros P Vassilakopoulos; Marina P Siakantaris; Flora N Kontopidou; Vassiliki A Boussiotis; C Papavassiliou; Christos Kittas; Gerassimos A Pangalis
EBVD combination chemotherapy plus low dose involved field radiation is a highly effective treatment modality for early stage Hodgkin's disease.
Leukemia & lymphoma 2000;37(1-2):131-43.
2000: Vassiliki A Boussiotis; Gordon J Freeman; Patricia A Taylor; Alla Berezovskaya; I Grass; B R Blazar; Lee M Nadler
p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes.
Nature medicine 2000;6(3):290-7.
2000: Leonard J Appleman; Alla Berezovskaya; I Grass; Vassiliki A Boussiotis
CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):144-51.
1999: Vassiliki A Boussiotis; Arnold S Freedman; Lee M Nadler
Bone marrow transplantation for low-grade lymphoma and chronic lymphocytic leukemia.
Seminars in hematology 1999;36(2):209-16.
1998: Gordon J Freeman; Angelo A Cardoso; Vassiliki A Boussiotis; Anukanth Anumanthan; Richard W Groves; Thomas S Kupper; E A Clark; Lee M Nadler
The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):2708-15.
1998: Paolo Ghia; Vassiliki A Boussiotis; Joachim L Schultze; Angelo A Cardoso; D M Dorfman; John G Gribben; Arnold S Freedman; Lee M Nadler
Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival.
Blood 1998;91(1):244-51.
1997: Vassiliki A Boussiotis; Gordon J Freeman; Alla Berezovskaya; Dwayne Barber; Lee M Nadler
Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1.
Science (New York, N.Y.) 1997;278(5335):124-8.
1997: Vassiliki A Boussiotis; B J Lee; Gordon J Freeman; John G Gribben; Lee M Nadler
Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3156-67.
1997: Angelo A Cardoso; MJ Seamon; H M Afonso; Paolo Ghia; Vassiliki A Boussiotis; Gordon J Freeman; John G Gribben; Stephen E Sallan; Lee M Nadler
Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells.
Blood 1997;90(2):549-61.
1996: C D Gimmi; B W Morrison; B A Mainprice; John G Gribben; Vassiliki A Boussiotis; Gordon J Freeman; S Y Park; M Watanabe; J Gong; Daniel F Hayes; Donald Kufe; Lee M Nadler
Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells.
Nature medicine 1996;2(12):1367-70.
1996: K T Hall; Laurence Boumsell; Joachim L Schultze; Vassiliki A Boussiotis; David M Dorfman; Angelo A Cardoso; Armand Bensussan; Lee M Nadler; Gordon J Freeman
Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11780-5.
1996: Vassiliki A Boussiotis; Gordon J Freeman; John G Gribben; Lee M Nadler
The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response.
Immunological reviews 1996;153():5-26.
1996: Vassiliki A Boussiotis; N A Pardo; H Collins; Alan N Houghton; Jerome Ritz; Lee M Nadler; Robert J Soiffer
R24 anti-GD3 ganglioside antibody can induce costimulation and prevent the induction of alloantigen-specific T cell clonal anergy.
European journal of immunology 1996;26(9):2149-54.
1996: Vassiliki A Boussiotis; Dwayne Barber; B J Lee; John G Gribben; Gordon J Freeman; Lee M Nadler
Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.
The Journal of experimental medicine 1996;184(2):365-76.
1996: Angelo A Cardoso; Joachim L Schultze; Vassiliki A Boussiotis; Gordon J Freeman; M J Seamon; S Laszlo; A Billet; Stephen E Sallan; John G Gribben; Lee M Nadler
Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen.
Blood 1996;88(1):41-8.
1996: John G Gribben; Eva C Guinan; Vassiliki A Boussiotis; X Y Ke; L Linsley; Colin A Sieff; GS Gray; Gordon J Freeman; Lee M Nadler
Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool.
Blood 1996;87(11):4887-93.
1995: Gordon J Freeman; Vassiliki A Boussiotis; Anukanth Anumanthan; G M Bernstein; X Y Ke; P D Rennert; GS Gray; John G Gribben; Lee M Nadler
B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.
Immunity 1995;2(5):523-32.
1995: Vassiliki A Boussiotis; Gordon J Freeman; John G Gribben; Lee M Nadler
The critical role of CD28 signalling in the prevention of human T-cell anergy.
Research in immunology 1995;146(3):140-9.
1995: John G Gribben; Gordon J Freeman; Vassiliki A Boussiotis; P Rennert; C L Jellis; E Greenfield; M Barber; V A Restivo; X Ke; GS Gray
CTLA4 mediates antigen-specific apoptosis of human T cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(3):811-5.
1994: Eva C Guinan; John G Gribben; Vassiliki A Boussiotis; Gordon J Freeman; Lee M Nadler
Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity.
Blood 1994;84(10):3261-82.
1994: Vassiliki A Boussiotis; Dwayne Barber; T Nakarai; Gordon J Freeman; John G Gribben; G M Bernstein; Alan D D'Andrea; Jerome Ritz; Lee M Nadler
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.
Science (New York, N.Y.) 1994;266(5187):1039-42.
1994: Vassiliki A Boussiotis; Gordon J Freeman; James D Griffin; GS Gray; John G Gribben; Lee M Nadler
CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy.
The Journal of experimental medicine 1994;180(5):1665-73.
1994: Vassiliki A Boussiotis; John G Gribben; Gordon J Freeman; Lee M Nadler
Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance.
Current opinion in immunology 1994;6(5):797-807.
1994: Vassiliki A Boussiotis; Lee M Nadler; Jack L Strominger; Anne E Goldfeld
Tumor necrosis factor alpha is an autocrine growth factor for normal human B cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7007-11.
1993: G Salles; M Zain; W M Jiang; Vassiliki A Boussiotis; Margaret A Shipp
Alternatively spliced CD44 transcripts in diffuse large-cell lymphomas: characterization and comparison with normal activated B cells and epithelial malignancies.
Blood 1993;82(12):3539-47.
1993: Vassiliki A Boussiotis; Gordon J Freeman; John G Gribben; J Daley; G Gray; Lee M Nadler
Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11059-63.
1993: Gordon J Freeman; John G Gribben; Vassiliki A Boussiotis; J W Ng; V A Restivo; L A Lombard; GS Gray; Lee M Nadler
Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation.
Science (New York, N.Y.) 1993;262(5135):909-11.
1993: Vassiliki A Boussiotis; Gordon J Freeman; G Gray; John G Gribben; Lee M Nadler
B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.
The Journal of experimental medicine 1993;178(5):1753-63.
1992: Anne E Goldfeld; EK Flemington; Vassiliki A Boussiotis; C M Theodos; Richard G Titus; Jack L Strominger; Samuel H Speck
Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):12198-201.