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André van Kuilenburg

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André B P van Kuilenburg; Jan Gerard Maring
Evaluation of 5-fluorouracil pharmacokinetic models and therapeutic drug monitoring in cancer patients.
Jaap J Kloek; Willem Kulik; X Maréchal; Rémi Nevière; Jeroen Roelofsen; Thomas M van Gulik; André B P van Kuilenburg; Rick Bezemer; Riekelt H Houtkooper; Michal Heger
Cholestasis is associated with hepatic microvascular dysfunction and aberrant energy metabolism before and during ischemia-reperfusion.
Jan Balzarini; Federico Gago; Anna Karlsson; Wim Kulik; Matt A Peterson; André B P van Kuilenburg; Morris J Robins
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.

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2013: André B P van Kuilenburg; Jan Gerard Maring
Evaluation of 5-fluorouracil pharmacokinetic models and therapeutic drug monitoring in cancer patients.
Pharmacogenomics 2013;14(7):799-811.
2012: Jaap J Kloek; Willem Kulik; X Maréchal; Rémi Nevière; Jeroen Roelofsen; Thomas M van Gulik; André B P van Kuilenburg; Rick Bezemer; Riekelt H Houtkooper; Michal Heger
Cholestasis is associated with hepatic microvascular dysfunction and aberrant energy metabolism before and during ischemia-reperfusion.
Antioxidants & redox signaling 2012;17(8):1109-23.
2012: Jan Balzarini; Federico Gago; Anna Karlsson; Wim Kulik; Matt A Peterson; André B P van Kuilenburg; Morris J Robins
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
The Journal of biological chemistry 2012;287(36):30444-54.
2012: André B P van Kuilenburg; Wang Xu; Chunhua Zhang; Lida Zoetekouw; N G G M Abeling; Birgit Assmann; Doreen Dobritzsch; Martin Engvall; Kaoru Eto; Tetsuya Ito; Michael Krumpel; Bernhard Lohkamp; Judith Meijer; Rutger Meinsma; Mohamed S Rashed; Kayoko Saito; Laila A Selim; Martin Smitka; Raoul C M Hennekam
ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients.
Biochimica et biophysica acta 2012;1822(7):1096-108.
2012: Odette G Besançon; Huib N Caron; Jerry Hoebink; Ulrich Jaehde; Ganna V Kalayda; René Leen; Rutger Meinsma; Godelieve A M Tytgat; André B P van Kuilenburg
Synergistic interaction between cisplatin and gemcitabine in neuroblastoma cell lines and multicellular tumor spheroids.
Cancer letters 2012;319(1):23-30.
2012: André B P van Kuilenburg; Detlev Behnke; Peter Häusler; Kati Jabschinsky; Johannes H Proost; Andreas Schalhorn; Wolfgang Schwabe; Michael W T Tanck; Christoph Terborg; Jan Gerard Maring
Evaluation of 5-fluorouracil pharmacokinetics in cancer patients with a c.1905+1G>A mutation in DPYD by means of a Bayesian limited sampling strategy.
Clinical pharmacokinetics 2012;51(3):163-74.
2012: Charlotte J P Beurskens; Janneke Horn; Hamid Aslami; Maria T Kuipers; Joris J T H Roelofs; Marcus J Schultz; André B P van Kuilenburg; Margreeth B Vroom; Nicole P Juffermans
Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover*.
Critical care medicine 2012;40(3):919-26.
2011: Maurice C van Staveren; Henk-Jan Guchelaar; Barbara Theeuwes-Oonk; André B P van Kuilenburg; Jan Gerard Maring
Pharmacokinetics of orally administered uracil in healthy volunteers and in DPD-deficient patients, a possible tool for screening of DPD deficiency.
Cancer chemotherapy and pharmacology 2011;68(6):1611-7.
2011: Roos Cuperus; René Leen; Johannes Bras; Huib N Caron; André B P van Kuilenburg; Godelieve A M Tytgat
Promising effects of the 4HPR-BSO combination in neuroblastoma monolayers and spheroids.
Free radical biology & medicine 2011;51(6):1213-20.
2011: André B P van Kuilenburg; Carlo R Largiadèr
SNPs and Haplotypes in DPYD and Outcome of Capecitabine-Letter.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(17):5837; author reply 5835-6.
2011: Sabine Weidensee; Peter Goettig; Marko Bertone; Dorothea Haas; Viktor Magdolen; Marion Kiechle; Alfons Meindl; André B P van Kuilenburg; Eva Gross
A mild phenotype of dihydropyrimidine dehydrogenase deficiency and developmental retardation associated with a missense mutation affecting cofactor binding.
Clinical biochemistry 2011;44(8-9):722-4.
2011: A Rosen; André B P van Kuilenburg; Birgit Assmann; M Kuhlen; A Borkhardt
Severe encephalopathy, lactic acidosis, vegetative instability and neuropathy with 5-Fluorouracil treatment - pyrimidine degradation defect or beriberi?
Case reports in oncology 2011;4(2):371-6.
2010: André B P van Kuilenburg; Judith Meijer; Adri N P M Mul; Rutger Meinsma; Veronika Schmid; Doreen Dobritzsch; Raoul C M Hennekam; Marcel M A M Mannens; Marion Kiechle; Marie-Christine Etienne-Grimaldi; Heinz-Josef Klümpen; Jan Gerard Maring; Veerle A Derleyn; Ed Maartense; Gérard Milano; Raymon Vijzelaar; Eva Gross
Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity.
Human genetics 2010;128(5):529-38.
2010: Thijs W H Pols; Peter I Bonta; Nuno M M Pires; Iker Otermin; Mariska Vos; Margreet R De Vries; Marco van Eijk; Jeroen Roelofsen; Louis M Havekes; Paul H A Quax; André B P van Kuilenburg; Vivian de Waard; Hans Pannekoek; Carlie J M de Vries
6-mercaptopurine inhibits atherosclerosis in apolipoprotein e*3-leiden transgenic mice through atheroprotective actions on monocytes and macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(8):1591-7.
2010: André B P van Kuilenburg; Doreen Dobritzsch; Judith Meijer; Rutger Meinsma; Jean-François Benoist; Birgit Assmann; Susanne Schubert; Georg F Hoffmann; Marinus Duran; Maaike C de Vries; Gerd Kurlemann; François J M Eyskens; Lawrence Greed; Jörn Oliver Sass; K Otfried Schwab; Adrian C Sewell; John Walter; Andreas Hahn; Lida Zoetekouw; Antonia Ribes; Suzanne Lind; Raoul C M Hennekam
Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients.
Biochimica et biophysica acta 2010;1802(7-8):639-48.
2010: E Uzer; F Dilmec; Feridun Akkafa; O Boduroglu; André B P van Kuilenburg
Investigation of CTLA-4 and CD28 gene polymorphisms in patients with diabetes mellitus type 2 using PCR-RFLP in a Turkish population.
The West Indian medical journal 2010;59(3):235-40.
2010: André B P van Kuilenburg; J Meijer; G Gökcay; T Baykal; M E Rubio-Gozalbo; A N P M Mul; C E M de Die-Smulders; P Weber; A Capone Mori; J Bierau; B Fowler; K Macke; Jörn Oliver Sass; Rutger Meinsma; J B Hennermann; Peter Miny; Lida Zoetekouw; J Roelofsen; Raymon Vijzelaar; J Nicolai; R C M Hennekam
Dihydropyrimidine dehydrogenase deficiency caused by a novel genomic deletion c.505_513del of DPYD.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):509-14.
2010: André B P van Kuilenburg; Lida Zoetekouw; J Meijer; Taco W Kuijpers
Identification of purine nucleoside phosphorylase deficiency in dried blood spots by a non-radiochemical assay using reversed-phase high-performance liquid chromatography.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):466-70.
2010: André B P van Kuilenburg; Lida Zoetekouw; J Meijer; Taco W Kuijpers
Determination of adenosine deaminase activity in dried blood spots by a nonradiochemical assay using reversed-phase high-performance liquid chromatography.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):461-5.
2010: Fuat Dilmec; Elmas Uzer; Feridun Akkafa; Elif Kose; André B P van Kuilenburg
Detection of VDR gene ApaI and TaqI polymorphisms in patients with type 2 diabetes mellitus using PCR-RFLP method in a Turkish population.
Journal of diabetes and its complications 2010;24(3):186-91.
2010: Roos Cuperus; René Leen; Godelieve A M Tytgat; Huib N Caron; André B P van Kuilenburg
Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma.
Cellular and molecular life sciences : CMLS 2010;67(5):807-16.
2009: André B P van Kuilenburg; Judith Meijer; Adri N P M Mul; Raoul Hennekam; Jan M N Hoovers; Christine E M de Die-Smulders; Peter Weber; Andrea Capone Mori; Jörgen Bierau; Brian Fowler; Klaus Macke; Jörn Oliver Sass; Rutger Meinsma; Julia B Hennermann; Peter Miny; Lida Zoetekouw; Raymon Vijzelaar; Joost Nicolai; Bauke Ylstra; M Estela Rubio-Gozalbo
Analysis of severely affected patients with dihydropyrimidine dehydrogenase deficiency reveals large intragenic rearrangements of DPYD and a de novo interstitial deletion del(1)(p13.3p21.3).
Human genetics 2009;125(5-6):581-90.
2009: Chris Van Bree; Angeliqué D Barten-Van Rijbroek; René Leen; Hans M Rodermond; André B P van Kuilenburg; Henk B Kal
Cyclopentenyl cytosine has biological and anti-tumour activity, but does not enhance the efficacy of gemcitabine and radiation in two animal tumour models.
International journal of oncology 2009;34(3):813-9.
2008: Sanjay U C Sankatsing; Jan M Prins; Si-La Yong; Jeroen Roelofsen; André B P van Kuilenburg; Steve Kewn; David J Back; Frederike J Bemelman; Ineke J M ten Berge
Mycophenolate mofetil inhibits T-cell proliferation in kidney transplant recipients without lowering intracellular dGTP and GTP.
Transplant international : official journal of the European Society for Organ Transplantation 2008;21(11):1066-71.
2008: André B P van Kuilenburg; A E M Stroomer; A M Bosch; M Duran
Beta-alanine and beta-aminoisobutyric acid levels in two siblings with dihydropyrimidinase deficiency.
Nucleosides, nucleotides & nucleic acids 2008;27(6):825-9.
2008: André B P van Kuilenburg; J Meijer; D Dobritzsch; B Lohkamp; W Ruitenbeek; J Roelofsen; N G G M Abeling; M Duran; C Buzing
Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria.
Nucleosides, nucleotides & nucleic acids 2008;27(6):809-15.
2008: André B P van Kuilenburg; Heinz-Josef Klumpen; Anneke M Westermann; Lida Zoetekouw; Piet J M Bakker; Henk-Jan Guchelaar; Dick J Richel
Altered dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil containing chemotherapy.
Nucleosides, nucleotides & nucleic acids 2008;27(6):726-32.
2008: André B P van Kuilenburg; J G Maring; A Schalhorn; Christoph Terborg; H Schmalenberg; D Behnke; W Schwabe; K Jabschinsky; P Hausler
Pharmacokinetics of 5-fluorouracil in patients heterozygous for the IVS14+1G > A mutation in the dihydropyrimidine dehydrogenase gene.
Nucleosides, nucleotides & nucleic acids 2008;27(6):692-8.
2008: Nanne K H De Boer; Ad van Bodegraven; Peer de Graaf; Rene W M van der Hulst; Lida Zoetekouw; André B P van Kuilenburg
Paradoxical elevated thiopurine S-methyltransferase activity after pancytopenia during azathioprine therapy: potential influence of red blood cell age.
Therapeutic drug monitoring 2008;30(3):390-3.
2008: Roos Cuperus; Godelieve A M Tytgat; René Leen; Pedro Brites; Johannes Bras; Huib N Caron; André B P van Kuilenburg
Pleiotropic effects of fenretinide in neuroblastoma cell lines and multicellular tumor spheroids.
International journal of oncology 2008;32(5):1011-9.
2008: Chris van Bree; André B P van Kuilenburg
Will cyclopentenyl cytosine (CPEC) ever have a future in the clinic?
Leukemia research 2008;32(2):201-2.
2008: Artur Mazur; Szymon Figurski; Anna Płoskoń; Judith Meijer; Lida Zoetekouw; Stanisława Watróbska; Jolanta Sykut-Cegielska; Wanda Gradowska; André B P van Kuilenburg
Dihydropyrimidine dehydrogenase deficiency presenting with psychomotor retardation in the first Polish patient.
Acta biochimica Polonica 2008;55(4):787-90.
2007: Arjan de Brouwer; Kelly L Williams; John A Duley; André B P van Kuilenburg; Sander B Nabuurs; Michael Egmont-Petersen; Dorien Lugtenberg; Lida Zoetekouw; Martijn J G Banning; Melissa Roeffen; Ben C J Hamel; Linda S Weaving; Robert Ouvrier; Jennifer A Donald; Ron A Wevers; John Christodoulou; Hans van Bokhoven
Arts syndrome is caused by loss-of-function mutations in PRPS1.
American journal of human genetics 2007;81(3):507-18.
2007: André B P van Kuilenburg; Judith Meijer; Doreen Dobritzsch; Rutger Meinsma; Marinus Duran; Bernhard Lohkamp; Lida Zoetekouw; N G G M Abeling; Herman L G van Tinteren; Annet M Bosch
Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency.
Molecular genetics and metabolism 2007;91(2):157-64.
2007: André B P van Kuilenburg; Henk Van Lenthe; Lida Zoetekouw; Willem Kulik
HPLC-electrospray tandem mass spectrometry for rapid determination of dihydropyrimidine dehydrogenase activity.
Clinical chemistry 2007;53(3):528-30.
2007: André B P van Kuilenburg; Heinz-Josef Klumpen; Anneke M Westermann; Lida Zoetekouw; Henk Van Lenthe; P J M Bakker; Dick J Richel; Henk-Jan Guchelaar
Increased dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil and leucovorin.
European journal of cancer (Oxford, England : 1990) 2007;43(2):459-65.
2006: André B P van Kuilenburg
Screening for dihydropyrimidine dehydrogenase deficiency: to do or not to do, that's the question.
Cancer investigation 2006;24(2):215-7.
2006: Annemieke J M de Ruijter; René Leen; Jerry Hoebink; Huib N Caron; André B P van Kuilenburg
Antagonistic effects of sequential administration of BL1521, a histone deacetylase inhibitor, and gemcitabine to neuroblastoma cells.
Cancer letters 2006;233(2):240-6.
2006: Birgit Assmann; G Göhlich; M Baethmann; Ron A Wevers; Albert H van Gennip; André B P van Kuilenburg; C Dietrich; L Wagner; J J Rotteveel; Jörg Schaper; Ertan Mayatepek; Georg F Hoffmann; Thomas Voit
Clinical findings and a therapeutic trial in the first patient with beta-ureidopropionase deficiency.
Neuropediatrics 2006;37(1):20-5.
2006: André B P van Kuilenburg; Lida Zoetekouw
Determination of thymidine phosphorylase activity in human blood cells and fibroblasts by a nonradiochemical assay using reversed-phase high-performance liquid chromatography.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1261-4.
2006: André B P van Kuilenburg; Henk Van Lenthe; Jan Gerard Maring; Albert H van Gennip
Determination of 5-fluorouracil in plasma with HPLC-tandem mass spectrometry.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1257-60.
2006: André B P van Kuilenburg; Bianca T van Maldegem; N G G M Abeling; Frits A Wijburg; Marinus Duran
Analysis of pyrimidine synthesis de novo intermediates in urine during crisis of a patient with ornithine transcarbamylase deficiency.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1251-5.
2006: André B P van Kuilenburg; Henk Van Lenthe; Albert H van Gennip
Activity of pyrimidine degradation enzymes in normal tissues.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1211-4.
2006: André B P van Kuilenburg; Alida E M Stroomer; N G G M Abeling; Albert H van Gennip
A pivotal role for beta-aminoisobutyric acid and oxidative stress in dihydropyrimidine dehydrogenase deficiency?
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1103-6.
2006: W Brussel; André B P van Kuilenburg; P M W Janssens
A neonate with recurrent vomiting and generalized hypotonia diagnosed with a deficiency of dihydropyrimidine dehydrogenase.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1099-102.
2006: André B P van Kuilenburg; Rutger Meinsma; B Assman; G F Hoffman; Thomas Voit; Antonia Ribes; Isabel Lorente; R Busch; Ertan Mayatepek; N G G M Abeling; Ron A Wevers; F Rutsch; Albert H van Gennip
Genetic analysis of the first 4 patients with beta-ureidopropionase deficiency.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1093-8.
2006: Birgit Assmann; André B P van Kuilenburg; Felix Distelmaier; N G G M Abeling; Thorsten Rosenbaum; Jörg Schaper; Marinus Duran; Ertan Mayatepek
Beta-ureidopropionase deficiency presenting with febrile status epilepticus.
Epilepsia 2006;47(1):215-7.
2006: Jörgen Bierau; Albert H van Gennip; René Leen; Rutger Meinsma; Huib N Caron; André B P van Kuilenburg
Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma.
Cancer chemotherapy and pharmacology 2006;57(1):105-13.
2005: Ramon Martí; Jan J Verschuuren; Alan Buchman; Ikuo Hirano; Saba Tadesse; André B P van Kuilenburg; Albert H van Gennip; B J H M Poorthuis; Michio Hirano
Late-onset MNGIE due to partial loss of thymidine phosphorylase activity.
Annals of neurology 2005;58(4):649-52.
2005: Annemieke J M de Ruijter; Rutger J Meinsma; Peter Bosma; Stephan Kemp; Huib N Caron; André B P van Kuilenburg
Gene expression profiling in response to the histone deacetylase inhibitor BL1521 in neuroblastoma.
Experimental cell research 2005;309(2):451-67.
2005: André B P van Kuilenburg; Lida Zoetekouw
Determination of thymidine phosphorylase activity by a non-radiochemical assay using reversed-phase high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;820(2):271-275.
2005: Giovanni Codacci-Pisanelli; HERBERT PINEDO; Jan Lankelma; Cees J van Groeningen; André B P van Kuilenburg; A H Van Gennip; Godefridus J Peters
Pharmacokinetics of bolus 5-fluorouracil: relationship between dose, plasma concentrations, area-under-the-curve and toxicity.
Journal of chemotherapy (Florence, Italy) 2005;17(3):315-20.
2005: Kirsten J M Schimmel; Roelof J Bennink; Kora de Bruin; Rene Leen; Karsten Sand; Maurice J B Van Den Hoff; André B P van Kuilenburg; Jean-Luc Vanderheyden; Neil Steinmetz; Martin Pfaffendorf; Arnauld C Verschuur; Henk-Jan Guchelaar
Absence of cardiotoxicity of the experimental cytotoxic drug cyclopentenyl cytosine (CPEC) in rats.
Archives of toxicology 2005;79(5):268-76.
2005: André B P van Kuilenburg; Rutger Meinsma; Eva Beke; Barbara Bobba; Patrizia Boffi; Gregory M Enns; David R Witt; Doreen Dobritzsch
Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function.
Biological chemistry 2005;386(4):319-24.
2005: Krista Ouwehand; Annemieke J M de Ruijter; Chris van Bree; Huib N Caron; André B P van Kuilenburg
Histone deacetylase inhibitor BL1521 induces a G1-phase arrest in neuroblastoma cells through altered expression of cell cycle proteins.
FEBS letters 2005;579(6):1523-8.
2005: N A Al-Sanna'a; André B P van Kuilenburg; T M Atrak; M A Abdul-Jabbar; A H Van Gennip
Dihydropyrimidine dehydrogenase deficiency presenting at birth.
Journal of inherited metabolic disease 2005;28(5):793-6.
2004: André B P van Kuilenburg; Rutger Meinsma; Eva Beke; Birgit Assmann; Antonia Ribes; Isabel Lorente; Rebekka Busch; Ertan Mayatepek; N G G M Abeling; Arno van Cruchten; Alida E M Stroomer; Henk Van Lenthe; Lida Zoetekouw; Willem Kulik; Georg F Hoffmann; Thomas Voit; Ron A Wevers; Frank Rutsch; Albert H van Gennip
beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities.
Human molecular genetics 2004;13(22):2793-801.
2004: André B P van Kuilenburg; Henk Van Lenthe; Monika Löffler; Albert H van Gennip
Analysis of pyrimidine synthesis "de novo" intermediates in urine and dried urine filter- paper strips with HPLC-electrospray tandem mass spectrometry.
Clinical chemistry 2004;50(11):2117-24.
2004: Arnauld C Verschuur; Albert H van Gennip; René Leen; André B P van Kuilenburg
Increased cytotoxicity of 2',2'-difluoro-2'-deoxycytidine in human leukemic cell-lines after a preincubation with cyclopentenyl cytosine.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1517-21.
2004: André B P van Kuilenburg; Rutger Meinsma; Albert H van Gennip
Pyrimidine degradation defects and severe 5-fluorouracil toxicity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1371-5.
2004: Godefridus J Peters; André B P van Kuilenburg; R A de Abreu
Purine and pyrimidine metabolism: new challenges.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1077-9.
2004: Annemieke J M de Ruijter; Stephan Kemp; Gertjan Kramer; Rutger J Meinsma; Judith O Kaufmann; Huib N Caron; André B P van Kuilenburg
The novel histone deacetylase inhibitor BL1521 inhibits proliferation and induces apoptosis in neuroblastoma cells.
Biochemical pharmacology 2004;68(7):1279-88.
2004: André B P van Kuilenburg
Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil.
European journal of cancer (Oxford, England : 1990) 2004;40(7):939-50.
2004: André B P van Kuilenburg; Alida E M Stroomer; Henk Van Lenthe; N G G M Abeling; Albert H van Gennip
New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?
The Biochemical journal 2004;379(Pt 1):119-24.
2004: Gregory M Enns; A James Barkovich; André B P van Kuilenburg; M Manning; T Sanger; D R Witt; A H van Gennip
Head imaging abnormalities in dihydropyrimidine dehydrogenase deficiency.
Journal of inherited metabolic disease 2004;27(4):513-22.
2004: André B P van Kuilenburg; Henk Van Lenthe; Arno van Cruchten; Willem Kulik
Quantification of 5,6-dihydrouracil by HPLC-electrospray tandem mass spectrometry.
Clinical chemistry 2004;50(1):236-8.
2003: Marjolijn M van der Eb; Sacha Geutskens; André B P van Kuilenburg; Henk van Lenthe; Jan Hein van Dierendonck; Peter Kuppen; Hans van Ormondt; Cornelis J H van de Velde; Ronald J A Wanders; Albert H van Gennip; Rob Hoeben
Ganciclovir nucleotides accumulate in mitochondria of rat liver cells expressing the herpes simplex virus thymidine kinase gene.
The journal of gene medicine 2003;5(12):1018-27.
2003: André B P van Kuilenburg; Rutger Meinsma; Bernard A Zonnenberg; Lida Zoetekouw; Frank Baas; Koichi Matsuda; Nanaya Tamaki; Albert H van Gennip
Dihydropyrimidinase deficiency and severe 5-fluorouracil toxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(12):4363-7.
2003: Tomiko Kuhara; Chie Ohdoi; Morimasa Ohse; André B P van Kuilenburg; Albert H van Gennip; Satoshi Sumi; Tetsuya Ito; Yoshiro Wada; Isamu Matsumoto
Rapid gas chromatographic-mass spectrometric diagnosis of dihydropyrimidine dehydrogenase deficiency and dihydropyrimidinase deficiency.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;792(1):107-15.
2003: Godefridus J Peters; Paul Noordhuis; André B P van Kuilenburg; Jan H Schornagel; Helen Gall; S L Turner; M S Swart; Daphne Voorn; A H Van Gennip; J Wanders; Ulbe Holwerda; Kees Smid; Giuseppe Giaccone; Pierre Fumoleau; Cees J van Groeningen
Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors.
Cancer chemotherapy and pharmacology 2003;52(1):1-12.
2003: Rebecca Sienaert; Lieve Naesens; Andrea Brancale; Antonella Carangio; Graciela Andrei; Robert Snoeck; André B P van Kuilenburg; Erik De Clercq; Christopher McGuigan; Jan Balzarini
Metabolic and pharmacological characteristics of the bicyclic nucleoside analogues (BCNAs) as highly selective inhibitors of varicella-zoster virus (VZV).
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):995-7.
2003: Annemieke J M de Ruijter; Albert H van Gennip; Huib N Caron; Stephan Kemp; André B P van Kuilenburg
Histone deacetylases (HDACs): characterization of the classical HDAC family.
The Biochemical journal 2003;370(Pt 3):737-49.
2003: André B P van Kuilenburg; J W Baars; R Meinsma; A H van Gennip
Lethal 5-fluorouracil toxicity associated with a novel mutation in the dihydropyrimidine dehydrogenase gene.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2003;14(2):341-2.
2003: Jörgen Bierau; Albert H van Gennip; René Leen; Jozien Helleman; Huib N Caron; André B P van Kuilenburg
Cyclopentenyl cytosine primes SK-N-BE(2)c neuroblastoma cells for cytarabine toxicity.
International journal of cancer. Journal international du cancer 2003;103(3):387-92.
2003: Agata Fiumara; André B P van Kuilenburg; U Caruso; C Nucifora; E Marzullo; Rita Barone; Concetta Meli; A H van Gennip
Dihydropyrimidine dehydrogenase deficiency and acute neurological presentation.
Journal of inherited metabolic disease 2003;26(4):407-9.
2003: Ronney A De Abreu; Robert C Trueworthy; André B P van Kuilenburg; Trude M Vogels-Mentink; Lambert H J Lambooy; Albert H van Gennip
Combination therapy in childhood leukaemia: in vitro studies of thiopurines and inhibitors of purine metabolism on apoptosis.
Annals of clinical biochemistry 2003;40(Pt 1):70-4.
2003: André B P van Kuilenburg; Ronney A De Abreu; Albert H van Gennip
Pharmacogenetic and clinical aspects of dihydropyrimidine dehydrogenase deficiency.
Annals of clinical biochemistry 2003;40(Pt 1):41-5.
2002: André B P van Kuilenburg; Rutger Meinsma; Lida Zoetekouw; Albert H van Gennip
High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity.
Pharmacogenetics 2002;12(7):555-8.
2002: André B P van Kuilenburg; Rutger Meinsma; Lida Zoetekouw; Albert H van Gennip
Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: high prevalence of the IVS14+1g>a mutation.
International journal of cancer. Journal international du cancer 2002;101(3):253-8.
2002: Jörgen Bierau; Albert H van Gennip; René Leen; Huib N Caron; André B P van Kuilenburg
Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells.
FEBS letters 2002;527(1-3):229-33.
2002: André B P van Kuilenburg; Doreen Dobritzsch; Rutger Meinsma; Janet Haasjes; Hans R Waterham; Malgorzata J M Nowaczyk; George D Maropoulos; Guido Hein; Hermann Kalhoff; Jean M Kirk; Holger Baaske; Anne Aukett; John A Duley; Kate P Ward; Ylva Lindqvist; Albert H van Gennip
Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure.
The Biochemical journal 2002;364(Pt 1):157-63.
2002: Jan Balzarini; Rebecca Sienaert; Sandra Liekens; André B P van Kuilenburg; Antonella Carangio; Robert M Esnouf; Erik De Clercq; Christopher McGuigan
Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase.
Molecular pharmacology 2002;61(5):1140-5.
2002: Jan Gerard Maring; André B P van Kuilenburg; Janet Haasjes; H Piersma; Harry J M Groen; D R A Uges; Albert H van Gennip; E G E de Vries
Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene.
British journal of cancer 2002;86(7):1028-33.
2002: Arnauld C Verschuur; Albert H van Gennip; René Leen; Paul A Voûte; Josanne Brinkman; André B P van Kuilenburg
Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-beta-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell line.
International journal of cancer. Journal international du cancer 2002;98(4):616-23.
2002: András Vermes; Henk-Jan Guchelaar; André B P van Kuilenburg; Jacob Dankert
5-fluorocytosine-related bone-marrow depression and conversion to fluorouracil: a pilot study.
Fundamental & clinical pharmacology 2002;16(1):39-47.
2001: André B P van Kuilenburg; Henk Van Lenthe; Birgit Assmann; G Göhlich-Ratmann; Georg F Hoffmann; Christa Bräutigam; Ron A Wevers; Albert H van Gennip
Detection of beta-ureidopropionase deficiency with HPLC-electrospray tandem mass spectrometry and confirmation of the defect at the enzyme level.
Journal of inherited metabolic disease 2001;24(7):725-32.
2001: Sytske H Moolenaar; G Göhlich-Ratmann; Udo F H Engelke; Manfred Spraul; Eberhard Humpfer; Peter Dvortsak; T Voit; Georg F Hoffmann; Christa Bräutigam; André B P van Kuilenburg; Albert H van Gennip; Peter Vreken; Ron A Wevers
beta-Ureidopropionase deficiency: a novel inborn error of metabolism discovered using NMR spectroscopy on urine.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(5):1014-7.
2001: Jörgen Bierau; Albert H van Gennip; Jozien Helleman; André B P van Kuilenburg
The cytostatic- and differentiation-inducing effects of cyclopentenyl cytosine on neuroblastoma cell lines.
Biochemical pharmacology 2001;62(8):1099-105.
2001: Arnauld C Verschuur; Josanne Brinkman; Albert H van Gennip; René Leen; R J Vet; L M Evers; Paul A Voûte; André B P van Kuilenburg
Cyclopentenyl cytosine induces apoptosis and increases cytarabine-induced apoptosis in a T-lymphoblastic leukemic cell-line.
Leukemia research 2001;25(10):891-900.
2001: André B P van Kuilenburg; Alida E M Stroomer; Godefridus J Peters; Albert H van Gennip
Simultaneous determination of F-beta-alanine and beta-alanine in plasma and urine with dual-column reversed-phase high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2001;759(1):51-61.
2001: André B P van Kuilenburg; E W Muller; Janet Haasjes; Rutger Meinsma; Lida Zoetekouw; Hans R Waterham; Frank Baas; Dick J Richel; Albert H van Gennip
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1149-53.
2000: André B P van Kuilenburg; Janet Haasjes; Dick J Richel; Lida Zoetekouw; Henk Van Lenthe; Ronney A De Abreu; Jan Gerard Maring; Peter Vreken; Albert H van Gennip
Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(12):4705-12.
2000: Henk Van Lenthe; André B P van Kuilenburg; T Ito; Albert H Bootsma; Arno van Cruchten; Y Wada; Albert H van Gennip
Defects in pyrimidine degradation identified by HPLC-electrospray tandem mass spectrometry of urine specimens or urine-soaked filter paper strips.
Clinical chemistry 2000;46(12):1916-22.
2000: André B P van Kuilenburg; Rutger Meinsma; Peter Vreken; Hans R Waterham; Albert H van Gennip
Identification of a cDNA encoding an isoform of human CTP synthetase.
Biochimica et biophysica acta 2000;1492(2-3):548-52.
2000: Arnauld C Verschuur; Albert H van Gennip; René Leen; Rutger Meinsma; P A Voute; André B P van Kuilenburg
In vitro inhibition of cytidine triphosphate synthetase activity by cyclopentenyl cytosine in paediatric acute lymphocytic leukaemia.
British journal of haematology 2000;110(1):161-9.
2000: T Ito; André B P van Kuilenburg; Albert H Bootsma; A J Haasnoot; Arno van Cruchten; Y Wada; Albert H van Gennip
The application of HPLC/ESI tandem mass spectrometry on urine-soaked filter-paper strips for the screening of disorders of purine and pyrimidine metabolism.
Journal of inherited metabolic disease 2000;23(4):434-7.
2000: T Ito; André B P van Kuilenburg; Albert H Bootsma; A J Haasnoot; Arno van Cruchten; Y Wada; Albert H van Gennip
Rapid screening of high-risk patients for disorders of purine and pyrimidine metabolism using HPLC-electrospray tandem mass spectrometry of liquid urine or urine-soaked filter paper strips.
Clinical chemistry 2000;46(4):445-52.
2000: Arnauld C Verschuur; Albert H van Gennip; René Leen; EJ Muller; L Elzinga; Paul A Voûte; André B P van Kuilenburg
Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy.
European journal of cancer (Oxford, England : 1990) 2000;36(5):627-35.
2000: Albert H van Gennip; Henk Van Lenthe; T Ito; Albert H Bootsma; A C Van Cruchten; Y Wada; André B P van Kuilenburg
HPLC/ESI tandem-MS of liquid urine or urine soaked filter-paper strips for the detection of thymine-uraciluria and dihydropyrimidinuria.
Advances in experimental medicine and biology 2000;486():377-82.
2000: Arnauld C Verschuur; Albert H van Gennip; Josanne Brinkman; Paul A Voûte; André B P van Kuilenburg
Cyclopentenyl cytosine induces apoptosis and secondary necrosis in a T-lymphoblastic leukemic cell-line.
Advances in experimental medicine and biology 2000;486():319-25.
2000: Arnauld C Verschuur; Albert H van Gennip; René Leen; Paul A Voûte; André B P van Kuilenburg
Cyclopentenyl cytosine increases the phosphorylation and incorporation into dna of arabinofu-ranosyl cytosine in a myeloid leukemic cell-line.
Advances in experimental medicine and biology 2000;486():311-7.
2000: Jörgen Bierau; Albert H van Gennip; André B P van Kuilenburg
Recovery of SK-N-BE(2)c cells from treatment with cyclopentenyl cytosine.
Advances in experimental medicine and biology 2000;486():277-80.
2000: André B P van Kuilenburg; Rutger Meinsma; Peter Vreken; Hans R Waterham; Albert H van Gennip
Isoforms of human CTP synthetase.
Advances in experimental medicine and biology 2000;486():257-61.
2000: André B P van Kuilenburg; Janet Haasjes; Henk Van Lenthe; Lida Zoetekouw; Hans R Waterham; Peter Vreken; Albert H van Gennip
Dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil associated toxicity.
Advances in experimental medicine and biology 2000;486():251-5.
2000: André B P van Kuilenburg; Janet Haasjes; Rutger Meinsma; Hans R Waterham; Peter Vreken; Albert H van Gennip
Dihydropyrimidine dehydrogenase (DPD) deficiency: novel mutations in the DPD gene.
Advances in experimental medicine and biology 2000;486():247-50.
2000: André B P van Kuilenburg; Henk Van Lenthe; G G Ratmann; Birgit Assmann; Georg F Hoffmann; C Brautigam; Albert H van Gennip
Confirmation of the enzyme defect in the first case of beta-ureidopropionase deficiency. Beta-alanine deficiency.
Advances in experimental medicine and biology 2000;486():243-6.
2000: Albert H van Gennip; André B P van Kuilenburg
Defects of pyrimidine degradation: clinical, molecular and diagnostic aspects.
Advances in experimental medicine and biology 2000;486():233-41.
1999: Peter Vreken; André B P van Kuilenburg; N Hamajima; Rutger Meinsma; Henk Van Lenthe; G Göhlich-Ratmann; Birgit Assmann; Ron A Wevers; Albert H van Gennip
cDNA cloning, genomic structure and chromosomal localization of the human BUP-1 gene encoding beta-ureidopropionase.
Biochimica et biophysica acta 1999;1447(2-3):251-7.
1999: André B P van Kuilenburg; Henk Van Lenthe; Albert H van Gennip
A radiochemical assay for beta-ureidopropionase using radiolabeled N-carbamyl-beta-alanine obtained via hydrolysis of [2-(14)C]5, 6-dihydrouracil.
Analytical biochemistry 1999;272(2):250-3.
1999: André B P van Kuilenburg; Henk Van Lenthe; A H Van Gennip
Radiochemical assay for determination of dihydropyrimidinase activity using reversed-phase high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1999;729(1-2):307-14.
1999: André B P van Kuilenburg; Peter Vreken; D Riva; G Botteon; N G G M Abeling; Henk D Bakker; Albert H van Gennip
Clinical and biochemical abnormalities in a patient with dihydropyrimidine dehydrogenase deficiency due to homozygosity for the C29R mutation.
Journal of inherited metabolic disease 1999;22(2):191-2.
1999: André B P van Kuilenburg; Henk Van Lenthe; MJ Blom; EP Mul; Albert H van Gennip
Profound variation in dihydropyrimidine dehydrogenase activity in human blood cells: major implications for the detection of partly deficient patients.
British journal of cancer 1999;79(3-4):620-6.
1999: André B P van Kuilenburg; Peter Vreken; N G G M Abeling; Henk D Bakker; Rutger Meinsma; Henk Van Lenthe; Ronney A De Abreu; Jan A M Smeitink; Hulya Kayserili; Memnune Y Apak; E Christensen; Irma E Holopainen; Kari Pulkki; D Riva; G Botteon; Elisabeth Holme; Már Tulinius; Wim J Kleijer; Frits A Beemer; Marinus Duran; Klary E Niezen-Koning; G Peter A Smit; Cornelis Jakobs; L M Smit; Albert H van Gennip
Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency.
Human genetics 1999;104(1):1-9.
1999: Arnauld C Verschuur; Albert H van Gennip; EJ Muller; Paul A Voûte; P Vreken; André B P van Kuilenburg
Cytidine triphosphate synthase activity and mRNA expression in normal human blood cells.
Biological chemistry 1999;380(1):41-6.
1998: RJ Slingerland; André B P van Kuilenburg; J M Bodlaender; Henk Overmars; Paul A Voûte; Albert H van Gennip
High-performance liquid chromatographic analysis of biogenic amines in cells and in culture media using on-line dialysis and trace enrichment.
Journal of chromatography. B, Biomedical sciences and applications 1998;716(1-2):65-75.
1998: André B P van Kuilenburg; Peter Vreken; LV Beex; Ronney A De Abreu; Albert H van Gennip
Severe 5-fluorouracil toxicity caused by reduced dihydropyrimidine dehydrogenase activity due to heterozygosity for a G-->A point mutation.
Journal of inherited metabolic disease 1998;21(3):280-4.
1998: Peter Vreken; André B P van Kuilenburg; Rutger Meinsma; Frits A Beemer; Marinus Duran; Albert H van Gennip
Dihydropyrimidine dehydrogenase deficiency: a novel mutation and expression of missense mutations in E. coli.
Journal of inherited metabolic disease 1998;21(3):276-9.
1998: André B P van Kuilenburg; Henk Van Lenthe; MJ Blom; EP Mul; Albert H van Gennip
The activity of dihydropyrimidine dehydrogenase in human blood cells.
Advances in experimental medicine and biology 1998;431():823-6.
1998: André B P van Kuilenburg; Henk Van Lenthe; Ronald J A Wanders; Albert H van Gennip
Subcellular localization of dihydropyrimidine dehydrogenase.
Advances in experimental medicine and biology 1998;431():817-21.
1998: André B P van Kuilenburg; Robert Poorter; Godefridus J Peters; Albert H van Gennip; Henk Van Lenthe; Alida E M Stroomer; Kees Smid; Paul Noordhuis; P J M Bakker; Cindy Veenhof
No circadian variation of dihydropyrimidine dehydrogenase, uridine phosphorylase, beta-alanine, and 5-fluorouracil during continuous infusion of 5-fluorouracil.
Advances in experimental medicine and biology 1998;431():811-6.
1998: Arnauld C Verschuur; Albert H van Gennip; EJ Muller; Paul A Voûte; André B P van Kuilenburg
Increased activity of cytidine Triphosphate synthetase in pediatric acute lymphoblastic leukemia.
Advances in experimental medicine and biology 1998;431():667-71.
1998: Peter Vreken; André B P van Kuilenburg; Rutger Meinsma; Albert H van Gennip
Dihydropyrimidine dehydrogenase deficiency. Identification of two novel mutations and expression of missense mutations in E. coli.
Advances in experimental medicine and biology 1998;431():341-6.
1998: André B P van Kuilenburg; Peter Vreken; LV Beex; Rutger Meinsma; Henk Van Lenthe; Ronney A De Abreu; Albert H van Gennip
Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity.
Advances in experimental medicine and biology 1998;431():293-8.
1998: André B P van Kuilenburg; L Elzinga; Albert H van Gennip
Kinetic properties of CTP synthetase from HL-60 cells.
Advances in experimental medicine and biology 1998;431():255-8.
1998: Albert H van Gennip; Ronney A De Abreu; Peter Vreken; André B P van Kuilenburg
Clinical and biochemical aspects of dihydropyrimidinase deficiency.
Advances in experimental medicine and biology 1998;431():125-8.
1997: Peter Vreken; André B P van Kuilenburg; Rutger Meinsma; Albert H van Gennip
Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W.
Human genetics 1997;101(3):333-8.
1997: André B P van Kuilenburg; Peter Vreken; LV Beex; Rutger Meinsma; Henk Van Lenthe; Ronney A De Abreu; Albert H van Gennip
Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity.
European journal of cancer (Oxford, England : 1990) 1997;33(13):2258-64.
1997: André B P van Kuilenburg; Henk Van Lenthe; Ronald J A Wanders; Albert H van Gennip
Subcellular localization of dihydropyrimidine dehydrogenase.
Biological chemistry 1997;378(9):1047-53.
1997: Birgit Assmann; Georg F Hoffmann; L Wagner; Christa Bräutigam; H W Seyberth; M Duran; André B P van Kuilenburg; Ron A Wevers; Albert H van Gennip
Dihydropyrimidinase deficiency and congenital microvillous atrophy: coincidence or genetic relation?
Journal of inherited metabolic disease 1997;20(5):681-8.
1997: Peter Vreken; André B P van Kuilenburg; Rutger Meinsma; Ronney A De Abreu; Albert H van Gennip
Identification of a four-base deletion (delTCAT296-299) in the dihydropyrimidine dehydrogenase gene with variable clinical expression.
Human genetics 1997;100(2):263-5.
1997: J Cornelissen; André B P van Kuilenburg; Paul A Voûte; Albert H van Gennip
MIBG causes oxidative stress and up-regulation of anti-oxidant enzymes in the human neuroblastoma cell line SK-N-BE(2c).
International journal of cancer. Journal international du cancer 1997;72(3):486-90.
1997: Albert H van Gennip; Henk Van Lenthe; N G G M Abeling; E G Scholten; André B P van Kuilenburg
Inhibition of beta-ureidopropionase by propionate may contribute to the neurological complications in patients with propionic acidaemia.
Journal of inherited metabolic disease 1997;20(3):379-82.
1997: Albert H van Gennip; Ronney A De Abreu; Henk Van Lenthe; J Bakkeren; Jan J Rotteveel; Peter Vreken; André B P van Kuilenburg
Dihydropyrimidinase deficiency: confirmation of the enzyme defect in dihydropyrimidinuria.
Journal of inherited metabolic disease 1997;20(3):339-42.
1997: Peter Vreken; André B P van Kuilenburg; Rutger Meinsma; Albert H van Gennip
Identification of novel point mutations in the dihydropyrimidine dehydrogenase gene.
Journal of inherited metabolic disease 1997;20(3):335-8.
1997: André B P van Kuilenburg; MJ Blom; Henk Van Lenthe; EP Mul; Albert H van Gennip
The activity of dihydropyrimidine dehydrogenase in human blood cells.
Journal of inherited metabolic disease 1997;20(3):331-4.
1997: André B P van Kuilenburg; L Elzinga; Arnauld C Verschuur; AA Van den Berg; RJ Slingerland; Albert H van Gennip
Determination of CTP synthetase activity in crude cell homogenates by a fast and sensitive non-radiochemical assay using anion-exchange high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1997;693(2):287-95.
1997: Albert H van Gennip; N G G M Abeling; Peter Vreken; André B P van Kuilenburg
Inborn errors of pyrimidine degradation: clinical, biochemical and molecular aspects.
Journal of inherited metabolic disease 1997;20(2):203-13.
1997: J Cornelissen; André B P van Kuilenburg; Paul A Voûte; Albert H van Gennip
The effect of the neuroblastoma-seeking agent meta-iodobenzylguanidine (MIBG) on NADH-driven superoxide formation and NADH-driven lipid peroxidation in beef heart submitochondrial particles.
European journal of cancer (Oxford, England : 1990) 1997;33(3):421-4.
1997: Godelieve A M Tytgat; J Cornelissen; Marieke Dekker van den Brug; André B P van Kuilenburg; P A Voute; A J Van der Kleij; Albert H van Gennip
HBO and the uptake and retention of [125I] MIBG in human platelets and two neuroendocrine cell lines.
Anticancer research 1997;17(2A):1209-12.
1997: Lori A Gustafson; M N Jumelle-Laclau; George M Van Woerkom; André B P van Kuilenburg; Alfred J Meijer
Cell swelling and glycogen metabolism in hepatocytes from fasted rats.
Biochimica et biophysica acta 1997;1318(1-2):184-90.
1997: RJ Slingerland; Albert H van Gennip; J M Bodlaender; Paul A Voûte; André B P van Kuilenburg
In-situ cytidine-deaminase activity and chromosome 1P deletion in human neuroblastoma cells.
Anticancer research 1997;17(1A):457-9.
1997: J Cornelissen; R Van Belzen; Albert H van Gennip; Paul A Voûte; André B P van Kuilenburg
Specification of the inhibitory action of MIBG on the respiratory chain by EPR scanning.
Anticancer research 1997;17(1A):265-8.
1997: J Cornelissen; André B P van Kuilenburg; L Elzinga; A D Van der Kleij; Paul A Voûte; Albert H van Gennip
Hyperbaric oxygen enhances the effects of meta-iodobenzylguanidine (MIBG) on energy metabolism and lipid peroxidation in the human neuroblastoma cell line SK-N-BE(2C).
Anticancer research 1997;17(1A):259-64.
1997: J Cornelissen; Godelieve A M Tytgat; Marieke Dekker van den Brug; André B P van Kuilenburg; Paul A Voûte; Albert H van Gennip
Menadione inhibits MIBG uptake in two neuroendocrine cell lines.
Journal of neuro-oncology 1997;31(1-2):147-51.
1996: Peter Vreken; André B P van Kuilenburg; Rutger Meinsma; G Peter A Smit; Henk D Bakker; Ronney A De Abreu; Albert H van Gennip
A point mutation in an invariant splice donor site leads to exon skipping in two unrelated Dutch patients with dihydropyrimidine dehydrogenase deficiency.
Journal of inherited metabolic disease 1996;19(5):645-54.
1996: André B P van Kuilenburg; Henk Van Lenthe; Albert H van Gennip
Identification and tissue-specific expression of a NADH-dependent activity of dihydropyrimidine dehydrogenase in man.
Anticancer research 1996;16(1):389-94.
1995: R J Slingerland; Albert H van Gennip; J M Bodlaender; Paul A Voûte; André B P van Kuilenburg
Quantitative analysis of the pyrimidine metabolism in pheochromocytoma PC-12 cells.
European journal of biochemistry / FEBS 1995;233(2):538-43.
1995: A A van Berg; P A Mooyer; Henk Van Lenthe; E H Stet; Ronney A De Abreu; André B P van Kuilenburg; Albert H van Gennip
The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate.
Biochemical pharmacology 1995;50(7):1095-8.
1995: R J Slingerland; Albert H van Gennip; J M Bodlaender; Paul A Voûte; André B P van Kuilenburg
The effect of cyclopentenyl cytosine on human SK-N-BE(2)-C neuroblastoma cells.
Biochemical pharmacology 1995;50(2):277-9.
1995: J Cornelissen; R J Wanders; Albert H van Gennip; C Van den Bogert; Paul A Voûte; André B P van Kuilenburg
Meta-iodobenzylguanidine inhibits complex I and III of the respiratory chain in the human cell line Molt-4.
Biochemical pharmacology 1995;49(4):471-7.
1995: Rutger Meinsma; Pedro Fernandez-Salguero; André B P van Kuilenburg; Albert H van Gennip; Frank J Gonzalez
Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea.
DNA and cell biology 1995;14(1):1-6.
1995: A A van den Berg; Henk Van Lenthe; J B Kipp; D de Korte; André B P van Kuilenburg; Albert H van Gennip
Cytidine triphosphate (CTP) synthetase activity during cell cycle progression in normal and malignant T-lymphocytic cells.
European journal of cancer (Oxford, England : 1990) 1995;31A(1):108-12.
1995: R J Slingerland; Albert H van Gennip; J M Bodlaender; Paul A Voûte; André B P van Kuilenburg
Cyclopentenyl cytosine and neuroblastoma SK-N-BE(2)-C cell line cells.
European journal of cancer (Oxford, England : 1990) 1995;31A(4):627-31.
1995: J Cornelissen; R J Wanders; C Van den Bogert; André B P van Kuilenburg; L Elzinga; Paul A Voûte; Albert H van Gennip
Meta-iodobenzylguanidine (MIBG) inhibits malate and succinate driven mitochondrial ATP synthesis in the human neuroblastoma cell line SK-N-BE(2c).
European journal of cancer (Oxford, England : 1990) 1995;31A(4):582-6.
1995: A H van Gennip; Henk Van Lenthe; N G G M Abeling; Henk D Bakker; André B P van Kuilenburg
Combined deficiencies of NADPH- and NADH-dependent dihydropyrimidine dehydrogenases, a new finding in a family with thymine-uraciluria.
Journal of inherited metabolic disease 1995;18(2):185-8.
1994: A A van den Berg; Henk Van Lenthe; S Busch; D de Korte; André B P van Kuilenburg; Albert H van Gennip
The roles of uridine-cytidine kinase and CTP synthetase in the synthesis of CTP in malignant human T-lymphocytic cells.
Leukemia 1994;8(8):1375-8.
1994: André B P van Kuilenburg; L Elzinga; A A Van den Berg; R J Slingerland; Albert H van Gennip
A fast and novel assay of CTP synthetase. Evidence for hysteretic properties of the mammalian enzyme.
Anticancer research 1994;14(2A):411-5.
1994: André B P van Kuilenburg; A A Van den Berg; J R Meinsma; R J Slingerland; Albert H van Gennip
Inhibition of CTP synthetase induces differentiation of HL-60 cells and down-regulation of the c-myc oncogene.
Advances in experimental medicine and biology 1994;370():761-4.
1994: Robert B Diasio; André B P van Kuilenburg; Z Lu; Ruiwen Zhang; Henk Van Lenthe; Henk D Bakker; A H Van Gennip
Determination of dihydropyrimidine dehydrogenase (DPD) in fibroblasts of a DPD deficient pediatric patient and family members using a polyclonal antibody to human DPD.
Advances in experimental medicine and biology 1994;370():7-10.
1994: R J Slingerland; André B P van Kuilenburg; J Bodlaender; Henk Van Lenthe; E Kreuk; Paul A Voûte; Albert H van Gennip
Compartmentation of ribonucleotides in PC-12 cells: free and protein bound ribonucleotides.
Advances in experimental medicine and biology 1994;370():283-6.
1994: R J Slingerland; André B P van Kuilenburg; J Bodlaender; Henk Van Lenthe; E Kreuk; Paul A Voûte; Albert H van Gennip
Imbalance between the pyrimidine ribonucleotide pools in rat rhabdomyosarcoma R1 cells.
Advances in experimental medicine and biology 1994;370():279-82.
1994: A A van den Berg; Henk Van Lenthe; André B P van Kuilenburg; Albert H van Gennip
The roles of uridine-cytidine kinase and CTP synthetase in the synthesis of CTP in malignant human T-lymphocytic cells.
Advances in experimental medicine and biology 1994;370():261-4.
1993: A A van den Berg; Henk Van Lenthe; S Busch; D de Korte; D Roos; André B P van Kuilenburg; Albert H van Gennip
Evidence for transformation-related increase in CTP synthetase activity in situ in human lymphoblastic leukemia.
European journal of biochemistry / FEBS 1993;216(1):161-7.
1992: André B P van Kuilenburg; A C Gorren; Henk L Dekker; P Nieboer; B F Van Gelder; Anton O Muijsers
Presteady-state and steady-state kinetic properties of human cytochrome c oxidase. Identification of rate-limiting steps in mammalian cytochrome c oxidase.
European journal of biochemistry / FEBS 1992;205(3):1145-54.
1992: André B P van Kuilenburg; J J Van Beeumen; H Demol; C Van den Bogert; I Schouten; Anton O Muijsers
Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform.
Biochimica et biophysica acta 1992;1119(2):218-24.
1992: C Van den Bogert; Henk L Dekker; J C Cornelissen; André B P van Kuilenburg; PA Bolhuis; Anton O Muijsers
Isoforms of cytochrome c oxidase in tissues and cell lines of the mouse.
Biochimica et biophysica acta 1992;1099(2):118-22.
1992: André B P van Kuilenburg; J J Van Beeumen; N M Van der Meer; Anton O Muijsers
Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.
European journal of biochemistry / FEBS 1992;203(1-2):193-9.
1991: André B P van Kuilenburg; Henk L Dekker; C Van den Bogert; P Nieboer; B F Van Gelder; Anton O Muijsers
Isoforms of human cytochrome-c oxidase. Subunit composition and steady-state kinetic properties.
European journal of biochemistry / FEBS 1991;199(3):615-22.
1990: J J Van Beeumen; André B P van Kuilenburg; S Van Bun; C Van den Bogert; J M Tager; Anton O Muijsers
Demonstration of two isoforms of subunit VIIa of cytochrome c oxidase from human skeletal muscle. Implications for mitochondrial myopathies.
FEBS letters 1990;263(2):213-6.
1988: André B P van Kuilenburg; Anton O Muijsers; H Demol; Henk L Dekker; J J Van Beeumen
Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence.
FEBS letters 1988;240(1-2):127-32.
1988: H Hoogland; Henk L Dekker; C van Riel; André B P van Kuilenburg; Anton O Muijsers; Ron Wever
A steady-state study on the formation of Compounds II and III of myeloperoxidase.
Biochimica et biophysica acta 1988;955(3):337-45.
1987: H Hoogland; André B P van Kuilenburg; C van Riel; Anton O Muijsers; Ron Wever
Spectral properties of myeloperoxidase compounds II and III.
Biochimica et biophysica acta 1987;916(1):76-82.