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Toin van Kuppevelt

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Katrien M Brouwer; Willeke F Daamen; Daphne Reijnen; Nicole van Lochem; R M H Wijnen; Toin H van Kuppevelt
Construction and in vivo evaluation of a dual layered collagenous scaffold with a radial pore structure for repair of the diaphragm.
Yinghui Zhang; Jacob A Irwin; Inchan Kwon; Robert L McKown; Ronald W Raab; Toin H van Kuppevelt; Ningning Wang; Gordon W Laurie
Targeting of Heparanase-modified Syndecan-1 by Prosecretory Mitogen Lacritin Requires Conserved Core GAGAL plus Heparan and Chondroitin Sulfate as a Novel Hybrid Binding Site That Enhances Selectivity.
L A J Roelofs; Paul P van den Berg; Toin H van Kuppevelt; AJ Crevels; Willeke F Daamen; AJ Eggink; W F J Feitz; Paul J Geutjes; Christina A Hulsbergen-van de Kaa; R M H Wijnen
Prenatal coverage of experimental gastroschisis with a collagen scaffold to protect the bowel.

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2013: Katrien M Brouwer; Willeke F Daamen; Daphne Reijnen; Nicole van Lochem; R M H Wijnen; Toin H van Kuppevelt
Construction and in vivo evaluation of a dual layered collagenous scaffold with a radial pore structure for repair of the diaphragm.
Acta biomaterialia 2013;9(6):6844-51.
2013: Yinghui Zhang; Jacob A Irwin; Inchan Kwon; Robert L McKown; Ronald W Raab; Toin H van Kuppevelt; Ningning Wang; Gordon W Laurie
Targeting of Heparanase-modified Syndecan-1 by Prosecretory Mitogen Lacritin Requires Conserved Core GAGAL plus Heparan and Chondroitin Sulfate as a Novel Hybrid Binding Site That Enhances Selectivity.
The Journal of biological chemistry 2013;288(17):12090-101.
2013: L A J Roelofs; Paul P van den Berg; Toin H van Kuppevelt; AJ Crevels; Willeke F Daamen; AJ Eggink; W F J Feitz; Paul J Geutjes; Christina A Hulsbergen-van de Kaa; R M H Wijnen
Prenatal coverage of experimental gastroschisis with a collagen scaffold to protect the bowel.
Journal of pediatric surgery 2013;48(3):516-24.
2013: Hong-Peng Li; Toin H van Kuppevelt; Junko Kimura-Kuroda; Yukari Komuta; Hitoshi Kawano
Roles of chondroitin sulfate and dermatan sulfate in the formation of a lesion scar and axonal regeneration after traumatic injury of the mouse brain.
Journal of neurotrauma 2013;30(5):413-25.
2013: Katrien M Brouwer; Willeke F Daamen; Henk R Hoogenkamp; Toin H van Kuppevelt
Regenerative medicine for the respiratory system: distant future or tomorrow's treatment?
American journal of respiratory and critical care medicine 2013;187(5):468-75.
2013: Kate A Meade; Anthony J Day; Rebecca J Holley; Andrew Marson; Claire E Pickford; Donna Tillotson; Toin H van Kuppevelt; Kathryn J White; Jason D Whittle; Catherine L R Merry
Immobilization of heparan sulfate on electrospun meshes to support embryonic stem cell culture and differentiation.
The Journal of biological chemistry 2013;288(8):5530-8.
2013: Kazumi Hirano; Toin H van Kuppevelt; Shoko Nishihara
The transition of mouse pluripotent stem cells from the naïve to the primed state requires Fas signaling through 3-O sulfated heparan sulfate structures recognized by the HS4C3 antibody.
Biochemical and biophysical research communications 2013;430(3):1175-81.
2013: Anna J S Houben; Alexander Fish; Jens Hausmann; Anastassis Perraks; Els M A van de Westerlo; Toin H van Kuppevelt; Laurens van Meeteren; Xander M R van Wijk; Leonie van Zeijl; Wouter H Moolenaar
The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans.
The Journal of biological chemistry 2013;288(1):510-9.
2013: Dick A W Janssen; John P F A Heesakkers; Kees C F J Jansen; Toin H van Kuppevelt; Xander M R van Wijk; Jack A Schalken
The distribution and function of chondroitin sulfate and other sulfated glycosaminoglycans in the human bladder and their contribution to the protective bladder barrier.
The Journal of urology 2013;189(1):336-42.
2012: Etienne van Bracht; Toin H van Kuppevelt; Wouter P R Verdurmen; Ronnie G P Wismans; Roland E Brock; Paul J Geutjes; Egbert Oosterwijk; René Raavé; Willeke F Daamen
Lyophilisomes as a new generation of drug delivery capsules.
International journal of pharmaceutics 2012;439(1-2):127-35.
2012: Rita A Buresh-Stiemke; Kimberly P Keil; Rita L Malinowski; Arie Oosterhof; Toin H van Kuppevelt; Chad M Vezina; Paul C Marker
Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.
Developmental dynamics : an official publication of the American Association of Anatomists 2012;241(12):2005-13.
2012: Xander M R van Wijk; Elly M Versteeg; Ronnie G Wismans; Henry B P M Dijkman; Wensi Hao; Arie Oosterhof; Julius Raben; Joost Schalkwijk; Toon F C M Smetsers; Myrtille J Vallen; Els M van de Westerlo; Toin H van Kuppevelt
Extraction and structural analysis of glycosaminoglycans from formalin-fixed, paraffin-embedded tissues.
Glycobiology 2012;22(12):1666-72.
2012: Theo G M F Gorgels; Johannes D Meeldijk; Suzan T M Nillesen; Peter Teeling; Allard C van der Wal; Toin H van Kuppevelt; Arthur A B Bergen
Abcc6 deficiency in the mouse leads to calcification of collagen fibers in Bruch's membrane.
Experimental eye research 2012;104():59-64.
2012: Nicol C Voermans; Toin H van Kuppevelt; Gaetano Vattemi; Gea Drost; F Gualandi; V Guglielmi; Erik-Jan Kamsteeg; A E Laan; Martin Lammens; Arie Oosterhof; C Scotton; L van den Heuvel; B G M van Engelen
Brody syndrome: a clinically heterogeneous entity distinct from Brody disease: a review of literature and a cross-sectional clinical study in 17 patients.
Neuromuscular disorders : NMD 2012;22(11):944-54.
2012: Cristina Ferreras; John M Gardiner; Gordon C Jayson; Graham Rushton; Brian A Telfer; Toin H van Kuppevelt; Kaye J Williams; Muhammad Babur; Claire L Cole; Egle Avizienyte
Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor.
The Journal of biological chemistry 2012;287(43):36132-46.
2012: Myrtille J E Vallen; Johan Bulten; Leon F A G Massuger; Gerdy B ten Dam; Toin H van Kuppevelt
Highly sulfated chondroitin sulfates, a novel class of prognostic biomarkers in ovarian cancer tissue.
Gynecologic oncology 2012;127(1):202-9.
2012: Weilun Sun; Dorien M Tiemessen; Toin H van Kuppevelt; Marije Sloff; Willeke F Daamen; Eric L W de Mulder; W F J Feitz; Paul J Geutjes; Bhuvanesh Gupta; Jöns Hilborn; Rianne J Lammers; Egbert Oosterwijk
Improving the cell distribution in collagen-coated poly-caprolactone knittings.
Tissue engineering. Part C, Methods 2012;18(10):731-9.
2012: Matthew Attreed; Muriel Desbois; Toin H van Kuppevelt; Hannes E Bülow
Direct visualization of specifically modified extracellular glycans in living animals.
Nature methods 2012;9(5):477-9.
2012: Tomomi Hosono-Fukao; Md Motarab Hossain; Koji Kimata; Makoto Michikawa; Kazuchika Nishitsuji; Shiori Ohtake-Niimi; Hiroyasu Akatsu; Markus Britschgi; Hitomi Hoshino; Toin H van Kuppevelt; Tony Wyss-Coray; Kenji Uchimura
Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid ß plaques of Alzheimer's disease: evidence from mouse models and patients.
The American journal of pathology 2012;180(5):2056-67.
2012: Gerwen Lammers; Ehab Ismail El=-Hallous; Günter Roth; Joost Schalkwijk; G Sandra Tjabringa; Roland Brock; Willeke F Daamen; Theo Hafmans; Mathias Heck; Elly M M Versteeg; Eugene T P Verwiel; Ronnie G P Wismans; Patrick L J M Zeeuwen; Roland Zengerle; Toin H van Kuppevelt
Construction of a microstructured collagen membrane mimicking the papillary dermis architecture and guiding keratinocyte morphology and gene expression.
Macromolecular bioscience 2012;12(5):675-91.
2012: Martin A Thelin; Toin H van Kuppevelt; Joseph Zaia; Mef Nilbert; Xiaofeng Shi; Katrin J Svensson; Jakob Axelsson; Mariam Bagher; Mattias Belting; Anna Isinger-Ekstrand; Jan Johansson; Marco Maccarana; Anders Malmström
Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma.
Cancer research 2012;72(8):1943-52.
2012: Minh Bao Huynh; Isabelle Martelly; Christophe Morin; Patricia Albanese; Véronique Barbier-Chassefière; Gilles Carpentier; Stephanie Garcia-Filipe; Sofia Talhas-Perret; Toin H van Kuppevelt; Dulce Papy-Garcia
Age-related changes in rat myocardium involve altered capacities of glycosaminoglycans to potentiate growth factor functions and heparan sulfate-altered sulfation.
The Journal of biological chemistry 2012;287(14):11363-73.
2012: Satoshi Nagamine; Tatsuyuki Ohto; Takuya Okada; Kensuke Shiomi; Satoru Takahashi; Michiko Tamba; Toin H van Kuppevelt; Ronnie G P Wismans; Kota Araki; Hisako Ishimine; Satoshi Kunita; Masayuki Masu; Kazuko Keino-Masu
Organ-specific sulfation patterns of heparan sulfate generated by extracellular sulfatases Sulf1 and Sulf2 in mice.
The Journal of biological chemistry 2012;287(12):9579-90.
2012: Helena C Christianson; Toin H van Kuppevelt; Mattias Belting
ScFv anti-heparan sulfate antibodies unexpectedly activate endothelial and cancer cells through p38 MAPK: implications for antibody-based targeting of heparan sulfate proteoglycans in cancer.
PloS one 2012;7(11):e49092.
2012: Kazumi Hirano; Tomomi Ichimiya; Taichi Miura; Norihiko Sasaki; Toin H van Kuppevelt; Shoko Nishihara
3-O-sulfated heparan sulfate recognized by the antibody HS4C3 contribute to the differentiation of mouse embryonic stem cells via Fas signaling.
PloS one 2012;7(8):e43440.
2012: Simon A W G Dello; Steven W M Olde Damink; Martijn Poeze; Kostan W Reisinger; Ronald M van Dam; Maartje A J van den Broek; Toin H van Kuppevelt; Marc H A Bemelmans; Wim A Buurman; Cornelis H C Dejong
Total intermittent Pringle maneuver during liver resection can induce intestinal epithelial cell damage and endotoxemia.
PloS one 2012;7(1):e30539.
2012: Mohamed Attia; Gilles Carpentier; José Courty; Arlette Duchesnay; Camille Gossard; Minh Bao Huynh; Alexander Scott; Louis J Soslowsky; Marie-Claude Tassoni; Toin H van Kuppevelt; Isabelle Martelly
Alterations of overused supraspinatus tendon: a possible role of glycosaminoglycans and HARP/pleiotrophin in early tendon pathology.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012;30(1):61-71.
2011: Tomomi Hosono-Fukao; Md Motarab Hossain; Makoto Michikawa; Kazuchika Nishitsuji; Shiori Ohtake-Niimi; Toin H van Kuppevelt; Kenji Uchimura
RB4CD12 epitope expression and heparan sulfate disaccharide composition in brain vasculature.
Journal of neuroscience research 2011;89(11):1840-8.
2011: Jennifer S Armistead; Toin H van Kuppevelt; Iain Wilson; Rhoel R Dinglasan
A role for heparan sulfate proteoglycans in Plasmodium falciparum sporozoite invasion of anopheline mosquito salivary glands.
The Biochemical journal 2011;438(3):475-83.
2011: Wouter P R Verdurmen; Parvesh Wadhwani; Petra H Bovee-Geurts; Mattias Hällbrink; Anne S Ulrich; Toin H van Kuppevelt; Roland Brock
Preferential uptake of L- versus D-amino acid cell-penetrating peptides in a cell type-dependent manner.
Chemistry & biology 2011;18(8):1000-10.
2011: Paul J Geutjes; Willeke F Daamen; kaeuis faraj; Toin H van Kuppevelt
Preparation of differently sized injectable collagen micro-scaffolds.
Journal of tissue engineering and regenerative medicine 2011;5(8):665-7.
2011: Simon J Clark; Lisa J Collinson; Anthony J Day; Helen L Fielder; Rebecca J Holley; Tiarnan D L Keenan; Catherine L R Merry; Toin H van Kuppevelt; Paul N Bishop
Mapping the differential distribution of glycosaminoglycans in the adult human retina, choroid, and sclera.
Investigative ophthalmology & visual science 2011;52(9):6511-21.
2011: Bart Smeets; Toin H van Kuppevelt; Jack F M Wetzels; Eva-Maria Sicking; Karlhans Endlich; Jürgen Floege; Astrid Fuss; Hermann-Josef Gröne; Peggy Jirak; Christoph Kuppe; Marcus J Moeller
Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis.
Journal of the American Society of Nephrology : JASN 2011;22(7):1262-74.
2011: Rogier M Reijmers; Marcel Spaargaren; Toin H van Kuppevelt; Kees Weijer; Richard W J Groen; Fiona C Kimberley; Annemieke Kuil; Jin-Ping Li; Jan Paul Medema; Steven T Pals
Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.
Blood 2011;117(23):6162-71.
2011: Katrien M Brouwer; Paul van Rensch; Veroniek E M Harbers; Paul J Geutjes; Martin J W Koens; René M H Wijnen; Willeke F Daamen; Toin H van Kuppevelt
Evaluation of methods for the construction of collagenous scaffolds with a radial pore structure for tissue engineering.
Journal of tissue engineering and regenerative medicine 2011;5(6):501-4.
2011: Gerwen Lammers; Els M van de Westerlo; Elly M Versteeg; Toin H van Kuppevelt; Willeke F Daamen
A comparison of seven methods to analyze heparin in biomaterials: quantification, location, and anticoagulant activity.
Tissue engineering. Part C, Methods 2011;17(6):669-76.
2011: Xiuxia Qu; Christian Carbe; Chenqi Tao; Andrea Powers; Roger Lawrence; Toin H van Kuppevelt; Wellington V Cardoso; Kay Grobe; Jeffrey D Esko; Xin Zhang
Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate.
The Journal of biological chemistry 2011;286(16):14435-44.
2011: Douglass Mccarty; Julianne DiRosario; Kadra Gulaid; Smruti Killedar; Arie Oosterhof; Toin H van Kuppevelt; Paul T Martin; Haiyan Fu
Differential distribution of heparan sulfate glycoforms and elevated expression of heparan sulfate biosynthetic enzyme genes in the brain of mucopolysaccharidosis IIIB mice.
Metabolic brain disease 2011;26(1):9-19.
2011: S T M Nillesen; G Lammers; Ronnie G P Wismans; Magda M W Ulrich; Esther Middelkoop; Paul H M Spauwen; kaeuis faraj; Joost Schalkwijk; Willeke F Daamen; Toin H van Kuppevelt
Design and in vivo evaluation of a molecularly defined acellular skin construct: reduction of early contraction and increase in early blood vessel formation.
Acta biomaterialia 2011;7(3):1063-71.
2011: Gerwen Lammers; Pauline D H M Verhaegen; Magda M W Ulrich; Joost Schalkwijk; Esther Middelkoop; Daniela Weiland; S T M Nillesen; Toin H van Kuppevelt; Willeke F Daamen
An overview of methods for the in vivo evaluation of tissue-engineered skin constructs.
Tissue engineering. Part B, Reviews 2011;17(1):33-55.
2011: Richard G Jansen; Toin H van Kuppevelt; Willeke F Daamen; Anne M Kuijpers-Jagtman; Johannes W Von Den Hoff
Interferon-γ-loaded collagen scaffolds reduce myofibroblast numbers in rat palatal mucosa.
European journal of orthodontics 2011;33(1):1-8.
2011: Sophie M Thompson; Jeremy E Turnbull; Toin H van Kuppevelt; Ruoyan Xu; Marilyn G Connell; David G Fernig; Paul D Losty; Edwin C Jesudason
Structure and epitope distribution of heparan sulfate is disrupted in experimental lung hypoplasia: a glycobiological epigenetic cause for malformation?
BMC developmental biology 2011;11():38.
2010: Nicole C Smits; Sindhulakshmi Kurup; Angelique L W M M Rops; Gerdy B ten Dam; Leon F Massuger; Theo Hafmans; Jeremy E Turnbull; Dorothe Spillmann; Jin-ping Li; Stephen J Kennel; Jonathan S Wall; Nicholas W Shworak; P N Richard Dekhuijzen; Johan Van der Vlag; Toin H van Kuppevelt
The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease.
The Journal of biological chemistry 2010;285(52):41143-51.
2010: M J W Koens; kaeuis faraj; Ronnie G P Wismans; J Adam van der Vliet; A G Krasznai; V M J I Cuijpers; John A Jansen; Willeke F Daamen; Toin H van Kuppevelt
Controlled fabrication of triple layered and molecularly defined collagen/elastin vascular grafts resembling the native blood vessel.
Acta biomaterialia 2010;6(12):4666-74.
2010: Shoujun Chen; Deborah Wassenhove-McCarthy; Yu Yamaguchi; Lawrence B Holzman; Toin H van Kuppevelt; A Wayne Orr; Steven Funk; Ann Woods; Kevin McCarthy
Podocytes require the engagement of cell surface heparan sulfate proteoglycans for adhesion to extracellular matrices.
Kidney international 2010;78(11):1088-99.
2010: E van Bracht; Paul J Geutjes; R Woestenenk; Ronnie G P Wismans; Egbert Oosterwijk; Toin H van Kuppevelt; Willeke F Daamen
Lyophilisomes: Potential carriers for tumor targeting.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):e7-8.
2010: Gerwen Lammers; Christian Gilissen; S T M Nillesen; Peter J E Uijtdewilligen; Ronnie G P Wismans; Joris A Veltman; Willeke F Daamen; Toin H van Kuppevelt
High density gene expression microarrays and gene ontology analysis for identifying processes in implanted tissue engineering constructs.
Biomaterials 2010;31(32):8299-312.
2010: Paul J Geutjes; J Adam van der Vliet; kaeuis faraj; Noes de Vries; Herman T B van Moerkerk; Ronnie G Wismans; Thijs Hendriks; Willeke F Daamen; Toin H van Kuppevelt
Preparation and characterization of injectable fibrillar type I collagen and evaluation for pseudoaneurysm treatment in a pig model.
Journal of vascular surgery 2010;52(5):1330-8.
2010: Jody E Nuininga; Martin J W Koens; Dorien M Tiemessen; Egbert Oosterwijk; Willeke F Daamen; Paul J Geutjes; Toin H van Kuppevelt; W F J Feitz
Urethral reconstruction of critical defects in rabbits using molecularly defined tubular type I collagen biomatrices: key issues in growth factor addition.
Tissue engineering. Part A 2010;16(11):3319-28.
2010: Xander M R van Wijk; Arie Oosterhof; Sebastiaan A M W van den Broek; Arjan W Griffioen; Gerdy B ten Dam; Floris P J T Rutjes; Floris L van Delft; Toin H van Kuppevelt
A 4-deoxy analogue of N-acetyl-D-glucosamine inhibits heparan sulphate expression and growth factor binding in vitro.
Experimental cell research 2010;316(15):2504-12.
2010: Paul J Geutjes; J Adam van der Vliet; kaeuis faraj; Noes de Vries; Herman T B van Moerkerk; Ronnie G Wismans; Thijs Hendriks; Willeke F Daamen; Toin H van Kuppevelt
An animal model for femoral artery pseudoaneurysms.
Journal of vascular and interventional radiology : JVIR 2010;21(7):1078-83.
2010: Nicole C Smits; Nicholas W Shworak; P N Richard Dekhuijzen; Toin H van Kuppevelt
Heparan sulfates in the lung: structure, diversity, and role in pulmonary emphysema.
Anatomical record (Hoboken, N.J. : 2007) 2010;293(6):955-67.
2010: Nynke A Hosper; Alex J Eggink; Luc A J Roelofs; Rene M H Wijnen; Marja J A van Luyn; Ruud A Bank; Martin C Harmsen; Paul J Geutjes; Willeke F Daamen; Toin H van Kuppevelt; Dorien M Tiemessen; Egbert Oosterwijk; Jane J Crevels; Willeke A M Blokx; Fred K Lotgering; Paul P van den Berg; Wout F J Feitz
Intra-uterine tissue engineering of full-thickness skin defects in a fetal sheep model.
Biomaterials 2010;31(14):3910-9.
2010: Nienke M Timmer; Tom J J Schirris; Ilona B Bruinsma; Irene Otte-Höller; Toin H van Kuppevelt; Robert M W de Waal; Marcel M Verbeek
Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Abeta40 (DAbeta(1-40)) are modulated by sulfate moieties of heparin.
Neuroscience research 2010;66(4):380-9.
2010: Gaetano Vattemi; Francesca Gualandi; Arie Oosterhof; Matteo Marini; Paola Tonin; Paola Rimessi; Marcella Neri; Valeria Guglielmi; Anna Russignan; Consuelo Poli; Toin H van Kuppevelt; Alessandra Ferlini; Giuliano Tomelleri
Brody disease: insights into biochemical features of SERCA1 and identification of a novel mutation.
Journal of neuropathology and experimental neurology 2010;69(3):246-52.
2010: Md Motarab Hossain; Tomomi Hosono-Fukao; Renhong Tang; Noriko Sugaya; Toin H van Kuppevelt; Guido J Jenniskens; Koji Kimata; Steven D Rosen; Kenji Uchimura
Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88.
Glycobiology 2010;20(2):175-86.
2010: Ilona B Bruinsma; Luuk te Riet; Tom Gevers; Gerdy B ten Dam; Toin H van Kuppevelt; Guido David; Benno Küsters; Robert M W de Waal; Marcel M Verbeek
Sulfation of heparan sulfate associated with amyloid-beta plaques in patients with Alzheimer's disease.
Acta neuropathologica 2010;119(2):211-20.
2010: Audrey Deligny; Agnès Denys; Adeline Marcant; Aurélie Melchior; Joel Mazurier; Toin H van Kuppevelt; Fabrice Allain
Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases.
The Journal of biological chemistry 2010;285(3):1701-15.
2010: Kenji Uchimura; Hassan Lemjabbar-Alaoui; Toin H van Kuppevelt; Steven D Rosen
Use of a phage display antibody to measure the enzymatic activity of the Sulfs.
Methods in enzymology 2010;480():51-64.
2010: Paul J Geutjes; S T M Nillesen; Gerwen Lammers; Willeke F Daamen; Toin H van Kuppevelt
Cloning, large-scale production, and purification of active dimeric rat vascular endothelial growth factor (rrVEGF-164).
Protein expression and purification 2010;69(1):76-82.
2009: Sophie M Thompson; David G Fernig; Edwin C Jesudason; Paul D Losty; Els M A van de Westerlo; Toin H van Kuppevelt; Jeremy E Turnbull
Heparan sulfate phage display antibodies identify distinct epitopes with complex binding characteristics: insights into protein binding specificities.
The Journal of biological chemistry 2009;284(51):35621-31.
2009: Anders Wittrup; Si-He Zhang; Gerdy B ten Dam; Toin H van Kuppevelt; Per Bengtson; Maria Johansson; Johanna Welch; Matthias Mörgelin; Mattias Belting
ScFv antibody-induced translocation of cell-surface heparan sulfate proteoglycan to endocytic vesicles: evidence for heparan sulfate epitope specificity and role of both syndecan and glypican.
The Journal of biological chemistry 2009;284(47):32959-67.
2009: G Lammers; G S Tjabringa; Joost Schalkwijk; Willeke F Daamen; Toin H van Kuppevelt
A molecularly defined array based on native fibrillar collagen for the assessment of skin tissue engineering biomaterials.
Biomaterials 2009;30(31):6213-20.
2009: kaeuis faraj; Vincent M J I Cuijpers; Ronnie G Wismans; X Frank Walboomers; John A Jansen; Toin H van Kuppevelt; Willeke F Daamen
Micro-computed tomographical imaging of soft biological materials using contrast techniques.
Tissue engineering. Part C, Methods 2009;15(3):493-9.
2009: Richard G Jansen; Toin H van Kuppevelt; Willeke F Daamen; Anne Marie Kuijpers-Jagtman; Johannes W Von Den Hoff
FGF-2-loaded collagen scaffolds attract cells and blood vessels in rat oral mucosa.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2009;38(8):630-8.
2009: Mieke M J F Koenders; Ronnie G Wismans; Barry Starcher; Ben C J Hamel; Richard P N Dekhuijzen; Toin H van Kuppevelt
Fibrillin-1 staining anomalies are associated with increased staining for TGF-beta and elastic fibre degradation; new clues to the pathogenesis of emphysema.
The Journal of pathology 2009;218(4):446-57.
2009: Gerdy B ten Dam; Shuhei Yamada; Fumi Kobayashi; Anurag Purushothaman; Els M A van de Westerlo; Johan Bulten; Anders Malmström; Kazuyuki Sugahara; L F A G Massuger; Toin H van Kuppevelt
Dermatan sulfate domains defined by the novel antibody GD3A12, in normal tissues and ovarian adenocarcinomas.
Histochemistry and cell biology 2009;132(1):117-27.
2009: Sengottuvelan Murugan; Kazuki N Sugahara; Chun Man Lee; Gerdy B ten Dam; Toin H van Kuppevelt; Masayuki Miyasaka; Shuhei Yamada; Kazuyuki Sugahara
Involvement of chondroitin sulfate E in the liver tumor focal formation of murine osteosarcoma cells.
Glycobiology 2009;19(7):735-42.
2009: Bellinda A Bladergroen; Bas Siebum; Kim G C Siebers-Vermeulen; Toin H van Kuppevelt; André A Poot; Jan Feijen; Carl G Figdor; Ruurd Torensma
In vivo recruitment of hematopoietic cells using stromal cell-derived factor 1 alpha-loaded heparinized three-dimensional collagen scaffolds.
Tissue engineering. Part A 2009;15(7):1591-9.
2009: Mieke M J F Koenders; Lanti Yang; Ronnie G Wismans; Kees O van der Werf; Ehab Ismail El=-Hallous; Willeke Daamen; Martin L Bennink; Pieter J Dijkstra; Toin H van Kuppevelt; Jan Feijen
Microscale mechanical properties of single elastic fibers: the role of fibrillin-microfibrils.
Biomaterials 2009;30(13):2425-32.
2009: Behzad Kharabi Masouleh; Gerdy B ten Dam; Martin K Wild; Ruth Seelige; Johan Van der Vlag; Angelique L Rops; Frank Echtermeyer; Dietmar Vestweber; Toin H van Kuppevelt; Ludwig Kiesel; Martin Götte
Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4985-93.
2009: Misha D P Luyer; Joep P M Derikx; Rudi Beyaert; M'hamed Hadfoune; Toin H van Kuppevelt; Cornelis H C Dejong; Erik Heineman; Wim A Buurman; Jan Willem M Greve
High-fat nutrition reduces hepatic damage following exposure to bacterial DNA and hemorrhagic shock.
Journal of hepatology 2009;50(2):342-50.
2008: Hannes Buelow; Nartono Tjoe; Robert A Townley; Dominic Didiano; Toin H van Kuppevelt; Oliver Hobert
Extracellular sugar modifications provide instructive and cell-specific information for axon-guidance choices.
Current biology : CB 2008;18(24):1978-85.
2008: Fuchuan Li; Gerdy B ten Dam; Sengottuvelan Murugan; Shuhei Yamada; Taishi Hashiguchi; Shuji Mizumoto; Kayoko Oguri; Minoru Okayama; Toin H van Kuppevelt; Kazuyuki Sugahara
Involvement of highly sulfated chondroitin sulfate in the metastasis of the Lewis lung carcinoma cells.
The Journal of biological chemistry 2008;283(49):34294-304.
2008: Nicol C Voermans; C G Bönnemann; P A Huijing; Ben C J Hamel; Toin H van Kuppevelt; Arnold De Haan; Joost Schalkwijk; B G M van Engelen; Guido J Jenniskens
Clinical and molecular overlap between myopathies and inherited connective tissue diseases.
Neuromuscular disorders : NMD 2008;18(11):843-56.
2008: Evelyn C Krenn; Iris Wille; Bernd Gesslbauer; Michael Poteser; Toin H van Kuppevelt; Andreas J Kungl
Glycanogenomics: a qPCR-approach to investigate biological glycan function.
Biochemical and biophysical research communications 2008;375(3):297-302.
2008: Paul O'Callaghan; Elina Sandwall; Jin-Ping Li; Hong Yu; Rivka Ravid; Zhi-Zhong Guan; Toin H van Kuppevelt; Lars N G Nilsson; Martin Ingelsson; Bradley T Hyman; Hannu Kalimo; Ulf Lindahl; Lars Lannfelt; Xiao Zhang
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.
Brain pathology (Zurich, Switzerland) 2008;18(4):548-61.
2008: Kazuki N Sugahara; Takako Hirata; Toshiyuki Tanaka; Shinji Ogino; Mitsuhiro Takeda; Hiroaki Terasawa; Ichio Shimada; Jun-ichi Tamura; Gerdy B ten Dam; Toin H van Kuppevelt; Masayuki Miyasaka
Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells.
Cancer research 2008;68(17):7191-9.
2008: Shoujun Chen; Deborah J Wassenhove-McCarthy; Yu Yamaguchi; Lawrence B Holzman; Toin H van Kuppevelt; Guido J Jenniskens; Tessa J Wijnhoven; Ann C Woods; Kevin J Mccarthy
Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria.
Kidney international 2008;74(3):289-99.
2008: Richard G Jansen; Anne Marie Kuijpers-Jagtman; Toin H van Kuppevelt; Johannes W Von Den Hoff
Collagen scaffolds implanted in the palatal mucosa.
The Journal of craniofacial surgery 2008;19(3):599-608.
2008: Johanna E Welch; Per Bengtson; Katrin Svensson; Anders Wittrup; Guido J Jenniskens; Gerdy B ten Dam; Toin H van Kuppevelt; Mattias Belting
Single chain fragment anti-heparan sulfate antibody targets the polyamine transport system and attenuates polyamine-dependent cell proliferation.
International journal of oncology 2008;32(4):749-56.
2008: Martin Götte; Dorothe Spillmann; George W Yip; Elly Versteeg; Frank Echtermeyer; Toin H van Kuppevelt; Ludwig Kiesel
Changes in heparan sulfate are associated with delayed wound repair, altered cell migration, adhesion and contractility in the galactosyltransferase I (beta4GalT-7) deficient form of Ehlers-Danlos syndrome.
Human molecular genetics 2008;17(7):996-1009.
2008: Richard G Jansen; Toin H van Kuppevelt; Willeke F Daamen; Anne Marie Kuijpers-Jagtman; Johannes W Von Den Hoff
Tissue reactions to collagen scaffolds in the oral mucosa and skin of rats: environmental and mechanical factors.
Archives of oral biology 2008;53(4):376-87.
2008: Els den Dekker; Sander Grefte; Tonnie Huijs; Gerdy B ten Dam; Elly M M Versteeg; Lieke van den Berk; Bellinda A Bladergroen; Toin H van Kuppevelt; Carl G Figdor; Ruurd Torensma
Monocyte cell surface glycosaminoglycans positively modulate IL-4-induced differentiation toward dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):3680-8.
2008: Weibo Zhang; X Frank Walboomers; Toin H van Kuppevelt; Willeke F Daamen; Philippe A Van Damme; Zhuan Bian; John A Jansen
In vivo evaluation of human dental pulp stem cells differentiated towards multiple lineages.
Journal of tissue engineering and regenerative medicine 2008;2(2-3):117-25.
2008: Willeke F Daamen; S T M Nillesen; Ronnie G P Wismans; Ehab Ismail El=-Hallous; Theo Hafmans; Jacques H Veerkamp; Toin H van Kuppevelt
A biomaterial composed of collagen and solubilized elastin enhances angiogenesis and elastic fiber formation without calcification.
Tissue engineering. Part A 2008;14(3):349-60.
2008: Antoine A Robbesom; Mieke M J F Koenders; Nicole Smits; Theo Hafmans; Elly M M Versteeg; Johan Bulten; Jacques H Veerkamp; P N R Dekhuijzen; Toin H van Kuppevelt
Aberrant fibrillin-1 expression in early emphysematous human lung: a proposed predisposition for emphysema.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008;21(3):297-307.
2008: Francesca Properzi; Rachel Lin; Jessica Kwok; Murali Naidu; Toin H van Kuppevelt; Gerdy B ten Dam; Luiz M Camargo; Ruma Raha-Chowdhury; Yoko Furukawa; Tadahisa Mikami; Kazuyuki Sugahara; James W Fawcett
Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation.
The European journal of neuroscience 2008;27(3):593-604.
2008: Tessa J M Wijnhoven; Mabel van den Hoven; H Ding; Toin H van Kuppevelt; Johan Van der Vlag; Jo H M Berden; R A Prinz; E J Lewis; M Schwartz; X Xu
Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy.
Diabetologia 2008;51(2):372-82.
2008: Mabel van den Hoven; Tessa J M Wijnhoven; J-P Li; E Zcharia; Henry B P M Dijkman; Ronnie G P Wismans; Angelique L W M M Rops; Joost Lensen; Lambert P van den Heuvel; Toin H van Kuppevelt; Israel Vlodavsky; Jo H M Berden; Johan Van der Vlag
Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria.
Kidney international 2008;73(3):278-87.
2008: Tessa J M Wijnhoven; Els M A van de Westerlo; Nicole Smits; Joost Lensen; Angelique L W M M Rops; Johan Van der Vlag; Jo H M Berden; Lambert P van den Heuvel; Toin H van Kuppevelt
Characterization of anticoagulant heparinoids by immunoprofiling.
Glycoconjugate journal 2008;25(2):177-85.
2008: L A J Roelofs; AJ Eggink; Christina A Hulsbergen-van de Kaa; R M H Wijnen; Toin H van Kuppevelt; H T B van Moerkerk; AJ Crevels; A Hanssen; Fred K Lotgering; Paul P van den Berg; W F J Feitz
Fetal bladder wall regeneration with a collagen biomatrix and histological evaluation of bladder exstrophy in a fetal sheep model.
Fetal diagnosis and therapy 2008;24(1):7-14.
2008: AJ Eggink; L A J Roelofs; W F J Feitz; R M H Wijnen; Martin Lammens; Reinier A Mullaart; H T B van Moerkerk; Toin H van Kuppevelt; AJ Crevels; Kiek Verrijp; Fred K Lotgering; Paul P van den Berg
Delayed intrauterine repair of an experimental spina bifida with a collagen biomatrix.
Pediatric neurosurgery 2008;44(1):29-35.
2008: Angelique L W M M Rops; Mabel van den Hoven; M M Baselmans; Joost Lensen; Tessa J M Wijnhoven; Lambert P van den Heuvel; Toin H van Kuppevelt; Jo H M Berden; Johan Van der Vlag
Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking.
Kidney international 2008;73(1):52-62.
2007: Tessa J M Wijnhoven; Joost Lensen; Ronnie G P Wismans; Dirk J Lefeber; Angelique L W M M Rops; Johan Van der Vlag; Jo H M Berden; Lambert P van den Heuvel; Toin H van Kuppevelt
Removal of heparan sulfate from the glomerular basement membrane blocks protein passage.
Journal of the American Society of Nephrology : JASN 2007;18(12):3119-27.
2007: Martha L Escobar Galvis; Juan Jia; Xiao Zhang; Nadja Jastrebova; Dorothe Spillmann; Eva Gottfridsson; Toin H van Kuppevelt; Eyal Zcharia; Israel Vlodavsky; Ulf Lindahl; Jin-Ping Li
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate.
Nature chemical biology 2007;3(12):773-8.
2007: Angelique L W M M Rops; Martin Götte; M H Baselmans; Mabel van den Hoven; Eric J Steenbergen; Joost Lensen; Tessa J M Wijnhoven; F Cevikbas; Lambert P van den Heuvel; Toin H van Kuppevelt; Jo H M Berden; Johan Van der Vlag
Syndecan-1 deficiency aggravates anti-glomerular basement membrane nephritis.
Kidney international 2007;72(10):1204-15.
2007: Rhoel R Dinglasan; Aditi Alaganan; Anil Ghosh; Akio Saito; Toin H van Kuppevelt; Marcelo Jacobs-Lorena
Plasmodium falciparum ookinetes require mosquito midgut chondroitin sulfate proteoglycans for cell invasion.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15882-7.
2007: Gerdy B ten Dam; Els M A van de Westerlo; Anurag Purushothaman; Radu V Stan; Johan Bulten; Fred C G J Sweep; L F A G Massuger; Kazuyuki Sugahara; Toin H van Kuppevelt
Antibody GD3G7 selected against embryonic glycosaminoglycans defines chondroitin sulfate-E domains highly up-regulated in ovarian cancer and involved in vascular endothelial growth factor binding.
The American journal of pathology 2007;171(4):1324-33.
2007: Willeke F Daamen; Jacques H Veerkamp; J C M van Hest; Toin H van Kuppevelt
Elastin as a biomaterial for tissue engineering.
Biomaterials 2007;28(30):4378-98.
2007: kaeuis faraj; Toin H van Kuppevelt; Willeke F Daamen
Construction of collagen scaffolds that mimic the three-dimensional architecture of specific tissues.
Tissue engineering 2007;13(10):2387-94.
2007: Tessa J M Wijnhoven; Joyce M Geelen; Marinka Bakker; Joost Lensen; Angelique L W M M Rops; Andrea B Kramer; gerjan navis; Mabel van den Hoven; Johan Van der Vlag; Jo H M Berden; Jack F M Wetzels; Lambert P van den Heuvel; Leo A H Monnens; Toin H van Kuppevelt
Adult and paediatric patients with minimal change nephrotic syndrome show no major alterations in glomerular expression of sulphated heparan sulphate domains.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(10):2886-93.
2007: Vaibhav Tiwari; Gerdy B ten Dam; Beatrice Y J T Yue; Toin H van Kuppevelt; Deepak Shukla
Role of 3-O-sulfated heparan sulfate in virus-induced polykaryocyte formation.
FEBS letters 2007;581(23):4468-72.
2007: Tessa J M Wijnhoven; Joost Lensen; Angelique L W M M Rops; Kevin J Mccarthy; Johan Van der Vlag; Jo H M Berden; Lambert P van den Heuvel; Toin H van Kuppevelt
Anti-proteinuric effects of glycosaminoglycan-based drugs.
Current opinion in molecular therapeutics 2007;9(4):364-77.
2007: Claire E Johnson; Brett E Crawford; Marios Stavridis; Gerdy B ten Dam; Annie L Wat; Graham Rushton; Christopher M Ward; Valerie Wilson; Toin H van Kuppevelt; Jeffrey D Esko; Austin Smith; John T Gallagher; Catherine L R Merry
Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells.
Stem cells (Dayton, Ohio) 2007;25(8):1913-23.
2007: Sindhulakshmi Kurup; Tessa J M Wijnhoven; Guido J Jenniskens; Koji Kimata; Hiroko Habuchi; Jin-Ping Li; Ulf Lindahl; Toin H van Kuppevelt; Dorothe Spillmann
Characterization of anti-heparan sulfate phage display antibodies AO4B08 and HS4E4.
The Journal of biological chemistry 2007;282(29):21032-42.
2007: Anurag Purushothaman; Junko Fukuda; Shuji Mizumoto; Gerdy B ten Dam; Toin H van Kuppevelt; Hiroshi Kitagawa; Tadahisa Mikami; Kazuyuki Sugahara
Functions of chondroitin sulfate/dermatan sulfate chains in brain development. Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7.
The Journal of biological chemistry 2007;282(27):19442-52.
2007: Angelique L W M M Rops; Mabel van den Hoven; Marinka A H Bakker; Joost Lensen; Tessa J M Wijnhoven; Lambert P van den Heuvel; Toin H van Kuppevelt; Johan Van der Vlag; Jo H M Berden
Expression of glomerular heparan sulphate domains in murine and human lupus nephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(7):1891-902.
2007: Coen A C Ottenheijm; Guido J Jenniskens; Maartje C P Geraedts; Theo Hafmans; Leo M A Heunks; Toin H van Kuppevelt; P N R Dekhuijzen
Diaphragm dysfunction in chronic obstructive pulmonary disease: a role for heparan sulphate?
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;30(1):80-9.
2007: Oren Hershkovitz; Sergey Jivov; Noga Bloushtain; Alon Zilka; Guy Landau; Ahuva Bar-Ilan; Rachel G Lichtenstein; Kerry S Campbell; Toin H van Kuppevelt; Angel Porgador
Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44.
Biochemistry 2007;46(25):7426-36.
2007: S M Thompson; Marilyn G Connell; David G Fernig; Gerdy B ten Dam; Toin H van Kuppevelt; Jeremy E Turnbull; Edwin C Jesudason; Paul D Losty
Novel 'phage display antibodies identify distinct heparan sulfate domains in developing mammalian lung.
Pediatric surgery international 2007;23(5):411-7.
2007: J J J P van den Beucken; X Frank Walboomers; S T M Nillesen; Matthijn R J Vos; Nico Sommerdijk; Toin H van Kuppevelt; Roeland J M Nolte; John A Jansen
In vitro and in vivo effects of deoxyribonucleic acid-based coatings funtionalized with vascular endothelial growth factor.
Tissue engineering 2007;13(4):711-20.
2007: Angelique L W M M Rops; Cor W Jacobs; Peter C Linssen; Jan B M Boezeman; Joost Lensen; Tessa J M Wijnhoven; Lambert P van den Heuvel; Toin H van Kuppevelt; Johan Van der Vlag; Jo H M Berden
Heparan sulfate on activated glomerular endothelial cells and exogenous heparinoids influence the rolling and adhesion of leucocytes.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(4):1070-7.
2007: Tessa J M Wijnhoven; Joost Lensen; Ronnie G P Wismans; Mohammed Lamrani; Leo A H Monnens; Ron A Wevers; Angelique L W M M Rops; Johan Van der Vlag; Jo H M Berden; Lambert P van den Heuvel; Toin H van Kuppevelt
In vivo degradation of heparan sulfates in the glomerular basement membrane does not result in proteinuria.
Journal of the American Society of Nephrology : JASN 2007;18(3):823-32.
2007: S T M Nillesen; Paul J Geutjes; Ronnie G P Wismans; Joost Schalkwijk; Willeke F Daamen; Toin H van Kuppevelt
Increased angiogenesis and blood vessel maturation in acellular collagen-heparin scaffolds containing both FGF2 and VEGF.
Biomaterials 2007;28(6):1123-31.
2006: Ronald R Gomes; Toin H van Kuppevelt; Mary C Farach-Carson; Daniel D Carson
Spatiotemporal distribution of heparan sulfate epitopes during murine cartilage growth plate development.
Histochemistry and cell biology 2006;126(6):713-22.
2006: S T M Nillesen; Paul J Geutjes; Ronnie G P Wismans; Joost Schalkwijk; Willeke F Daamen; Toin H van Kuppevelt
Increased angiogenesis in acellular scaffolds by combined release of FGF2 and VEGF.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e88-90.
2006: H T B van Moerkerk; P J E Uijtdewilligen; P Smits; Willeke F Daamen; Toin H van Kuppevelt
Preparation of a growth factor gradient in porous collagen scaffolds and its effect on cell growth proliferation.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e87-8.
2006: Willeke F Daamen; S T M Nillesen; Ronnie G P Wismans; D Reinhardt; Theo Hafmans; Jacques H Veerkamp; Toin H van Kuppevelt
Depots of solubilised elastin promote the formation of blood vessels and elastic fibres in rat.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e84-5.
2006: William C Lamanna; Rebecca J Baldwin; Michael Padva; Ina Kalus; Gerdy B ten Dam; Toin H van Kuppevelt; John T Gallagher; Kurt von Figura; Thomas Dierks; Catherine L R Merry
Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity.
The Biochemical journal 2006;400(1):63-73.
2006: Weibo Zhang; X Frank Walboomers; Toin H van Kuppevelt; Willeke F Daamen; Zhuan Bian; John A Jansen
The performance of human dental pulp stem cells on different three-dimensional scaffold materials.
Biomaterials 2006;27(33):5658-68.
2006: Joost Lensen; Tessa J M Wijnhoven; Leon H Kuik; Elly M M Versteeg; Theo Hafmans; Angelique L W M M Rops; M S G Pavao; Johan Van der Vlag; Lambert P van den Heuvel; Jo H M Berden; Toin H van Kuppevelt
Selection and characterization of a unique phage display-derived antibody against dermatan sulfate.
Matrix biology : journal of the International Society for Matrix Biology 2006;25(7):457-61.
2006: Andrea Kramer; Mabel van den Hoven; Angelique L W M M Rops; Tessa J M Wijnhoven; Lambert van Den Heuvel; Joost Lensen; Toin H van Kuppevelt; Harry van Goor; Johan Van der Vlag; gerjan navis; Jo H M Berden
Induction of glomerular heparanase expression in rats with adriamycin nephropathy is regulated by reactive oxygen species and the renin-angiotensin system.
Journal of the American Society of Nephrology : JASN 2006;17(9):2513-20.
2006: Tessa J M Wijnhoven; Joost Lensen; Angelique L W M M Rops; Johan Van der Vlag; Svein Olav Kolset; Hans-Jacob Bangstad; Per Pfeffer; Mabel van den Hoven; Jo H M Berden; Lambert P van den Heuvel; Toin H van Kuppevelt
Aberrant heparan sulfate profile in the human diabetic kidney offers new clues for therapeutic glycomimetics.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2006;48(2):250-61.
2006: Henry B P M Dijkman; J J Weening; Bart Smeets; Kiek Verrijp; Toin H van Kuppevelt; K K J M Assmann; Eric J Steenbergen; Jack F M Wetzels
Proliferating cells in HIV and pamidronate-associated collapsing focal segmental glomerulosclerosis are parietal epithelial cells.
Kidney international 2006;70(2):338-44.
2006: J H Wijnhoven; Antoon J M Janssen; Toin H van Kuppevelt; Richard J T Rodenburg; P N R Dekhuijzen
Metabolic capacity of the diaphragm in patients with COPD.
Respiratory medicine 2006;100(6):1064-71.
2006: Laura Buttafoco; Paula Engbers-Buijtenhuijs; Andre A Poot; Pieter J Dijkstra; Willeke F Daamen; Toin H van Kuppevelt; Istvan Vermes; Jan Feijen
First steps towards tissue engineering of small-diameter blood vessels: preparation of flat scaffolds of collagen and elastin by means of freeze drying.
Journal of biomedical materials research. Part B, Applied biomaterials 2006;77(2):357-68.
2006: Gerdy B ten Dam; Sindhulakshmi Kurup; Els M A van de Westerlo; Elly M M Versteeg; Ulf Lindahl; Dorothe Spillmann; Toin H van Kuppevelt
3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.
The Journal of biological chemistry 2006;281(8):4654-62.
2006: Edith L G M Tonnaer; Theo Hafmans; Toin H van Kuppevelt; Elisabeth A M Sanders; Paul E Verweij; Jo H A J Curfs
Involvement of glycosaminoglycans in the attachment of pneumococci to nasopharyngeal epithelial cells.
Microbes and infection / Institut Pasteur 2006;8(2):316-22.
2006: Guido J Jenniskens; Jacques H Veerkamp; Toin H van Kuppevelt
Heparan sulfates in skeletal muscle development and physiology.
Journal of cellular physiology 2006;206(2):283-94.
2006: Paul J Geutjes; Willeke F Daamen; Pieter Buma; Wout F Feitz; kaeuis faraj; Toin H van Kuppevelt
From molecules to matrix: construction and evaluation of molecularly defined bioscaffolds.
Advances in experimental medicine and biology 2006;585():279-95.
2006: Nicole Smits; Joost Lensen; Tessa J M Wijnhoven; Gerdy B ten Dam; Guido J Jenniskens; Toin H van Kuppevelt
Phage display-derived human antibodies against specific glycosaminoglycan epitopes.
Methods in enzymology 2006;416():61-87.
2006: AJ Eggink; L A J Roelofs; Martin Lammens; W F J Feitz; R M H Wijnen; Reinier A Mullaart; H T B van Moerkerk; Toin H van Kuppevelt; AJ Crevels; A Hanssen; Fred K Lotgering; Paul P van den Berg
Histological evaluation of acute covering of an experimental neural tube defect with biomatrices in fetal sheep.
Fetal diagnosis and therapy 2006;21(2):210-6.
2005: Alon Zilka; Guy Landau; Oren Hershkovitz; Noga Bloushtain; Ahuva Bar-Ilan; Fabrice Benchetrit; Eyal Fima; Toin H van Kuppevelt; John T Gallagher; Sharona Elgavish; Angel Porgador
Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46.
Biochemistry 2005;44(44):14477-85.
2005: AJ Eggink; L A J Roelofs; W F J Feitz; R M H Wijnen; Reinier A Mullaart; André Grotenhuis; Toin H van Kuppevelt; Martin Lammens; AJ Crevels; A Hanssen; Paul P van den Berg
In utero repair of an experimental neural tube defect in a chronic sheep model using biomatrices.
Fetal diagnosis and therapy 2005;20(5):335-40.
2005: Werner J H Koopman; Peter H G M Willems; Arie Oosterhof; Toin H van Kuppevelt; Stan C A M Gielen
Amplitude modulation of nuclear Ca2+ signals in human skeletal myotubes: a possible role for nuclear Ca2+ buffering.
Cell calcium 2005;38(2):141-52.
2005: Willeke F Daamen; Theo Hafmans; Jacques H Veerkamp; Toin H van Kuppevelt
Isolation of intact elastin fibers devoid of microfibrils.
Tissue engineering 2005;11(7-8):1168-76.
2005: Theo G M F Gorgels; Xiaofeng Hu; George L Scheffer; Allard C van der Wal; Johan Toonstra; Paulus T V M de Jong; Toin H van Kuppevelt; Christiaan N Levelt; Anneke de Wolf; Willem J P Loves; Rik J Scheper; Ron Peek; Arthur A B Bergen
Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum.
Human molecular genetics 2005;14(13):1763-73.
2005: Joost Lensen; Angelique L W M M Rops; Tessa J M Wijnhoven; Theo Hafmans; W F J Feitz; Egbert Oosterwijk; Bernhard Banas; René J M Bindels; Lambert P van den Heuvel; Johan Van der Vlag; Jo H M Berden; Toin H van Kuppevelt
Localization and functional characterization of glycosaminoglycan domains in the normal human kidney as revealed by phage display-derived single chain antibodies.
Journal of the American Society of Nephrology : JASN 2005;16(5):1279-88.
2005: Manon C Zweers; Willow B Dean; Toin H van Kuppevelt; James Bristow; Joost Schalkwijk
Elastic fiber abnormalities in hypermobility type Ehlers-Danlos syndrome patients with tenascin-X mutations.
Clinical genetics 2005;67(4):330-4.
2005: Manon C Zweers; Joost Schalkwijk; Toin H van Kuppevelt; Ivonne M J J van Vlijmen-Willems; Mieke Bergers; Claire Lethias; Evert Lamme
Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components.
Cell and tissue research 2005;319(2):279-87.
2005: Jan Stolk; Barbara Veldhuisen; Laura Annovazzi; Chiara Zanone; Elly M M Versteeg; Toin H van Kuppevelt; Jo H M Berden; Willem Nieuwenhuizen; Paolo Iadarola; Maurizio Luisetti
Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency.
Respiratory research 2005;6():47.
2005: Francesca Properzi; Daniela Carulli; Richard A Asher; Elizabeth M Muir; Luiz M Camargo; Toin H van Kuppevelt; Gerdy B ten Dam; Yoko Furukawa; Tadishima Mikami; Kazuyuki Sugahara; Toshihiko Toida; Herbert Geller; James W Fawcett
Chondroitin 6-sulphate synthesis is up-regulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia.
The European journal of neuroscience 2005;21(2):378-90.
2005: Isabelle Barbosa; Christophe Morin; Stéphanie Garcia; Arlette Duchesnay; Mustapha Oudghir; Guido Jenniskens; Hua-Quan Miao; Scott E Guimond; Gilles Carpentier; José Cebrian; Jean-Pierre Caruelle; Toin H van Kuppevelt; Jeremy Turnbull; Isabelle Martelly; Dulce Papy-Garcia
A synthetic glycosaminoglycan mimetic (RGTA) modifies natural glycosaminoglycan species during myogenesis.
Journal of cell science 2005;118(Pt 1):253-64.
2005: Xiaoping Zhu; Leo M A Heunks; Elly M M Versteeg; Henricus F M van der Heijden; Leo Ennen; Toin H van Kuppevelt; Jose Vina; P N R Dekhuijzen
Hypoxia-induced dysfunction of rat diaphragm: role of peroxynitrite.
American journal of physiology. Lung cellular and molecular physiology 2005;288(1):L16-26.
2005: Eun Ji Joo; Gerdy B ten Dam; Toin H van Kuppevelt; Toshihiko Toida; Robert J Linhardt; Yeong Shik Kim
Nucleolin: acharan sulfate-binding protein on the surface of cancer cells.
Glycobiology 2005;15(1):1-9.
2005: Willeke F Daamen; S T M Nillesen; Theo Hafmans; Jacques H Veerkamp; Marja J A van Luyn; Toin H van Kuppevelt
Tissue response of defined collagen-elastin scaffolds in young and adult rats with special attention to calcification.
Biomaterials 2005;26(1):81-92.
2004: Angelique L W M M Rops; Johan Van der Vlag; Cor W Jacobs; Henry B P M Dijkman; Joost Lensen; Tessa J M Wijnhoven; Lambert P van den Heuvel; Toin H van Kuppevelt; Jo H M Berden
Isolation and characterization of conditionally immortalized mouse glomerular endothelial cell lines.
Kidney international 2004;66(6):2193-201.
2004: Gerdy B ten Dam; Els M A van de Westerlo; Toon F C M Smetsers; Marieke P Willemse; Goos N P van Muijen; Catherine L R Merry; John T Gallagher; Yeong S Kim; Toin H van Kuppevelt
Detection of 2-O-sulfated iduronate and N-acetylglucosamine units in heparan sulfate by an antibody selected against acharan sulfate (IdoA2S-GlcNAc)n.
The Journal of biological chemistry 2004;279(37):38346-52.
2004: Manon C Zweers; Ivonne M J J van Vlijmen-Willems; Toin H van Kuppevelt; Robert P Mecham; Peter M Steijlen; James Bristow; Joost Schalkwijk
Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology.
The Journal of investigative dermatology 2004;122(4):885-91.
2004: Bart Smeets; Nathalie A J M te Loeke; Henry B P M Dijkman; Mark L M Steenbergen; Joost Lensen; Mark P V Begieneman; Toin H van Kuppevelt; Jack F M Wetzels; Eric J Steenbergen
The parietal epithelial cell: a key player in the pathogenesis of focal segmental glomerulosclerosis in Thy-1.1 transgenic mice.
Journal of the American Society of Nephrology : JASN 2004;15(4):928-39.
2004: Paula Buijtenhuijs; Laura Buttafoco; Andre A Poot; Willeke F Daamen; Toin H van Kuppevelt; Pieter J Dijkstra; Rob A I de Vos; Lotus M Th Sterk; Bob R H Geelkerken; Jan Feijen; Istvan Vermes
Tissue engineering of blood vessels: characterization of smooth-muscle cells for culturing on collagen-and-elastin-based scaffolds.
Biotechnology and applied biochemistry 2004;39(Pt 2):141-9.
2004: Jody E Nuininga; H T B van Moerkerk; A Hanssen; CA Hulsbergen; Jeannette C Oosterwijk-Wakka; Egbert Oosterwijk; R P E de Gier; Jack A Schalken; Toin H van Kuppevelt; W F J Feitz
A rabbit model to tissue engineer the bladder.
Biomaterials 2004;25(9):1657-61.
2004: Toon F C M Smetsers; Els M A van de Westerlo; Gerdy B ten Dam; Ingrid M Overes; Joost Schalkwijk; Goos N P van Muijen; Toin H van Kuppevelt
Human single-chain antibodies reactive with native chondroitin sulfate detect chondroitin sulfate alterations in melanoma and psoriasis.
The Journal of investigative dermatology 2004;122(3):707-16.
2004: Angelique L W M M Rops; Johan Van der Vlag; Joost Lensen; Tessa J M Wijnhoven; Lambert P van den Heuvel; Toin H van Kuppevelt; Jo H M Berden
Heparan sulfate proteoglycans in glomerular inflammation.
Kidney international 2004;65(3):768-85.
2004: Nicole Smits; Antoine A Robbesom; Elly M M Versteeg; Els M A van de Westerlo; P N R Dekhuijzen; Toin H van Kuppevelt
Heterogeneity of heparan sulfates in human lung.
American journal of respiratory cell and molecular biology 2004;30(2):166-73.
2003: Monique R Bernsen; Toon F C M Smetsers; Els M A van de Westerlo; Dirk J Ruiter; Leif Håkansson; Bertil Gustafsson; Toin H van Kuppevelt; Lennart Krysander; Björn Rettrup; Annika Håkansson
Heparan sulphate epitope-expression is associated with the inflammatory response in metastatic malignant melanoma.
Cancer immunology, immunotherapy : CII 2003;52(12):780-3.
2003: Werner J H Koopman; Michel Renders; Arie Oosterhof; Toin H van Kuppevelt; B G M van Engelen; Peter H G M Willems
Upregulation of Ca2+ removal in human skeletal muscle: a possible role for Ca2+-dependent priming of mitochondrial ATP synthesis.
American journal of physiology. Cell physiology 2003;285(5):C1263-9.
2003: Heidi Barth; Christiane Schafer; Mohammed I Adah; Fuming Zhang; Robert J Linhardt; Hidenao Toyoda; Akiko Kinoshita-Toyoda; Toshihiko Toida; Toin H van Kuppevelt; Erik Depla; Fritz Von Weizsacker; Hubert E Blum; Thomas F Baumert
Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate.
The Journal of biological chemistry 2003;278(42):41003-12.
2003: Willeke F Daamen; H T B van Moerkerk; Theo Hafmans; Laura Buttafoco; Andre A Poot; Jacques H Veerkamp; Toin H van Kuppevelt
Preparation and evaluation of molecularly-defined collagen-elastin-glycosaminoglycan scaffolds for tissue engineering.
Biomaterials 2003;24(22):4001-9.
2003: Jody E Nuininga; H T B van Moerkerk; A Hanssen; CA Hulsbergen; Jeannette C Oosterwijk-Wakka; Egbert Oosterwijk; R P E de Gier; Jack A Schalken; Toin H van Kuppevelt; W F J Feitz
Rabbit urethra replacement with a defined biomatrix or small intestinal submucosa.
European urology 2003;44(2):266-71.
2003: Pieter Buma; Jeroen S Pieper; Tony G van Tienen; Job L C van Susante; Peter van der Kraan; Jacques H Veerkamp; Wim B van den Berg; R P H Veth; Toin H van Kuppevelt
Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects--a study in rabbits.
Biomaterials 2003;24(19):3255-63.
2003: Toon F C M Smetsers; Els M A van de Westerlo; Gerdy B ten Dam; Ruud Clarijs; Elly M M Versteeg; Winny L Van Geloof; Jacques H Veerkamp; Goos N P van Muijen; Toin H van Kuppevelt
Localization and characterization of melanoma-associated glycosaminoglycans: differential expression of chondroitin and heparan sulfate epitopes in melanoma.
Cancer research 2003;63(11):2965-70.
2003: Gerdy B ten Dam; Theo Hafmans; Jacques H Veerkamp; Toin H van Kuppevelt
Differential expression of heparan sulfate domains in rat spleen.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003;51(6):727-39.
2003: Guido J Jenniskens; Maria Ringvall; Werner J H Koopman; Johan Ledin; Lena Kjellén; Peter H G M Willems; Erik Forsberg; Jacques H Veerkamp; Toin H van Kuppevelt
Disturbed Ca2+ kinetics in N-deacetylase/N-sulfotransferase-1 defective myotubes.
Journal of cell science 2003;116(Pt 11):2187-93.
2003: Guido J Jenniskens; Werner J H Koopman; Peter H G M Willems; Iris Pecker; Jacques H Veerkamp; Toin H van Kuppevelt
Phenotypic knock out of heparan sulfates in myotubes impairs excitation-induced calcium spiking.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(8):878-80.
2003: Antoine A Robbesom; Elly M M Versteeg; Jacques H Veerkamp; J H J M van Krieken; Hans J Bulten; Hans T J Smits; Luuk N A Willems; Cees van Herwaarden; P N R Dekhuijzen; Toin H van Kuppevelt
Morphological quantification of emphysema in small human lung specimens: comparison of methods and relation with clinical data.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2003;16(1):1-7.
2002: Jeroen S Pieper; Theo Hafmans; Pauline B van Wachem; Marja J A van Luyn; Linda A Brouwer; Jacques H Veerkamp; Toin H van Kuppevelt
Loading of collagen-heparan sulfate matrices with bFGF promotes angiogenesis and tissue generation in rats.
Journal of biomedical materials research 2002;62(2):185-94.
2002: Guido J Jenniskens; Theo Hafmans; Jacques H Veerkamp; Toin H van Kuppevelt
Spatiotemporal distribution of heparan sulfate epitopes during myogenesis and synaptogenesis: a study in developing mouse intercostal muscle.
Developmental dynamics : an official publication of the American Association of Anatomists 2002;225(1):70-9.
2002: Jeroen S Pieper; Peter van der Kraan; Theo Hafmans; J Kamp; Pieter Buma; Job L C van Susante; Wim B van den Berg; Jacques H Veerkamp; Toin H van Kuppevelt
Crosslinked type II collagen matrices: preparation, characterization, and potential for cartilage engineering.
Biomaterials 2002;23(15):3183-92.
2002: Els M A van de Westerlo; Toon F C M Smetsers; Michel A B A Dennissen; Robert J Linhardt; Jacques H Veerkamp; Goos N P van Muijen; Toin H van Kuppevelt
Human single chain antibodies against heparin: selection, characterization, and effect on coagulation.
Blood 2002;99(7):2427-33.
2002: Michel A B A Dennissen; Guido J Jenniskens; Martijn Pieffers; Elly M M Versteeg; Maurice Petitou; Jacques H Veerkamp; Toin H van Kuppevelt
Large, tissue-regulated domain diversity of heparan sulfates demonstrated by phage display antibodies.
The Journal of biological chemistry 2002;277(13):10982-6.
2001: Jeroen S Pieper; Pieter Buma; Toin H van Kuppevelt; Henk M van Beuningen; Peter van der Kraan; J H Veerkamp; Wim B van den Berg
Linkage of chondroitin-sulfate to type I collagen scaffolds stimulates the bioactivity of seeded chondrocytes in vitro.
Biomaterials 2001;22(17):2359-69.
2001: Willeke F Daamen; Theo Hafmans; Jacques H Veerkamp; Toin H van Kuppevelt
Comparison of five procedures for the purification of insoluble elastin.
Biomaterials 2001;22(14):1997-2005.
2001: Toin H van Kuppevelt; Guido J Jenniskens; Jacques H Veerkamp; Gerdy B ten Dam; Michel A B A Dennissen
Phage display technology to obtain antiheparan sulfate antibodies.
Methods in molecular biology (Clifton, N.J.) 2001;171():519-34.
2000: Maria Ringvall; Johan Ledin; Katarina Holmborn; Toin H van Kuppevelt; F Ellin; Inger Eriksson; A M Olofsson; Lena Kjellen; Erik Forsberg
Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1.
The Journal of biological chemistry 2000;275(34):25926-30.
2000: Jeroen S Pieper; Pauline B van Wachem; Linda A Brouwer; Theo Hafmans; Jacques H Veerkamp; Toin H van Kuppevelt
Attachment of glycosaminoglycans to collagenous matrices modulates the tissue response in rats.
Biomaterials 2000;21(16):1689-99.
2000: Guido J Jenniskens; Arie Oosterhof; R Brandwijk; Jacques H Veerkamp; Toin H van Kuppevelt
Heparan sulfate heterogeneity in skeletal muscle basal lamina: demonstration by phage display-derived antibodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(11):4099-111.
2000: Toin H van Kuppevelt; Antoine A Robbesom; Elly M M Versteeg; J E Veerkamp; Cees van Herwaarden; P N R Dekhuijzen
Restoration by vacuum inflation of original alveolar dimensions in small human lung specimens.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;15(4):771-7.
2000: Jeroen S Pieper; Theo Hafmans; Jacques H Veerkamp; Toin H van Kuppevelt
Development of tailor-made collagen-glycosaminoglycan matrices: EDC/NHS crosslinking, and ultrastructural aspects.
Biomaterials 2000;21(6):581-93.
1999: Jeroen S Pieper; Arie Oosterhof; P J Dijkstra; Jacques H Veerkamp; Toin H van Kuppevelt
Preparation and characterization of porous crosslinked collagenous matrices containing bioavailable chondroitin sulphate.
Biomaterials 1999;20(9):847-58.
1999: G L Portiér; A G Benders; Arie Oosterhof; Jacques H Veerkamp; Toin H van Kuppevelt
Differentiation markers of mouse C2C12 and rat L6 myogenic cell lines and the effect of the differentiation medium.
In vitro cellular & developmental biology. Animal 1999;35(4):219-27.
1999: Jacques H Veerkamp; H T B van Moerkerk; CF Prinsen; Toin H van Kuppevelt
Structural and functional studies on different human FABP types.
Molecular and cellular biochemistry 1999;192(1-2):137-42.
1998: Toin H van Kuppevelt; Michel A B A Dennissen; Walther J van Venrooij; René M A Hoet; Jacques H Veerkamp
Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidney.
The Journal of biological chemistry 1998;273(21):12960-6.
1998: Sander Groffen; C A Buskens; Toin H van Kuppevelt; Jacques H Veerkamp; Leo A H Monnens; Lambert P van den Heuvel
Primary structure and high expression of human agrin in basement membranes of adult lung and kidney.
European journal of biochemistry / FEBS 1998;254(1):123-8.
1997: Toin H van Kuppevelt; C H van de Lest; Elly M M Versteeg; P N R Dekhuijzen; Jacques H Veerkamp
Induction of emphysematous lesions in rat lung by beta-D-xyloside, an inhibitor of proteoglycan synthesis.
American journal of respiratory cell and molecular biology 1997;16(1):75-84.