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Vincent van Laak

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

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RNA Interference

Disorders

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Reverse Transcriptase Polymerase Chain Reaction

Physiology

Signal Transduction

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Publications

TOP 3
Philipp Mergenthaler; Lars Neeb; Josef Priller; Ingo Przesdzing; Katharina Stohlmann; Susanne Thomsen; Vincent van Laak; David W Andrews; Tony J Collins; Ulrich Dirnagl; Dorette Freyer; Anja Kahl; Anne Kamitz; Heiko Klawitter; Dirk Megow; Andreas Meisel
Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state.
Bastian Opitz; Vincent van Laak; Julia Eitel; Norbert Suttorp
Innate immune recognition in infectious and noninfectious diseases of the lung.
Claudia Buss; Bastian Opitz; Andreas C Hocke; Juliane Lippmann; Vincent van Laak; Stefan Hippenstiel; Matthias Krüll; Norbert Suttorp; Julia Eitel
Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells.

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All Publications

2012: Philipp Mergenthaler; Lars Neeb; Josef Priller; Ingo Przesdzing; Katharina Stohlmann; Susanne Thomsen; Vincent van Laak; David W Andrews; Tony J Collins; Ulrich Dirnagl; Dorette Freyer; Anja Kahl; Anne Kamitz; Heiko Klawitter; Dirk Megow; Andreas Meisel
Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(5):1518-23.
2010: Bastian Opitz; Vincent van Laak; Julia Eitel; Norbert Suttorp
Innate immune recognition in infectious and noninfectious diseases of the lung.
American journal of respiratory and critical care medicine 2010;181(12):1294-309.
2010: Claudia Buss; Bastian Opitz; Andreas C Hocke; Juliane Lippmann; Vincent van Laak; Stefan Hippenstiel; Matthias Krüll; Norbert Suttorp; Julia Eitel
Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(6):3072-8.
2009: Katrin Reppe; Thomas Tschernig; Anke Lührmann; Vincent van Laak; Karsten Grote; Maren V Zemlin; Birgitt Gutbier; Holger C Müller; Mischo Kursar; Hartwig Schütte; Simone Rosseau; Reinhard Pabst; Norbert Suttorp; Martin Witzenrath
Immunostimulation with macrophage-activating lipopeptide-2 increased survival in murine pneumonia.
American journal of respiratory cell and molecular biology 2009;40(4):474-81.
2009: Martin Witzenrath; Birgitt Gutbier; Bernd Schmeck; Herrmann Tenor; Joachim Seybold; Raimund Kuelzer; Guido Grentzmann; Armin Hatzelmann; Vincent van Laak; Thomas Tschernig; Tim Mitchell; Christian Schudt; Simone Rosseau; Norbert Suttorp; Hartwig Schütte
Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia.
Critical care medicine 2009;37(2):584-90.
2008: Juliane Lippmann; Stefan Rothenburg; Nikolaus Deigendesch; Julia Eitel; Karolin Meixenberger; Vincent van Laak; Hortense Slevogt; Philippe Dje N'Guessan; Stefan Hippenstiel; Trinad Chakraborty; Antje Flieger; Norbert Suttorp; Bastian Opitz
IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI).
Cellular microbiology 2008;10(12):2579-88.
2008: Bernd Schmeck; Janina Lorenz; Philippe Dje N'Guessan; Bastian Opitz; Vincent van Laak; Janine Zahlten; Hortense Slevogt; Martin Witzenrath; Antje Flieger; Norbert Suttorp; Stefan Hippenstiel
Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):940-7.
2006: Bernd Schmeck; Wiebke Beermann; Vincent van Laak; Bastian Opitz; Andreas C Hocke; Karolin Meixenberger; Julia Eitel; Trinad Chakraborty; Gudula Schmidt; Holger Barth; Norbert Suttorp; Stefan Hippenstiel
Listeria monocytogenes induced Rac1-dependent signal transduction in endothelial cells.
Biochemical pharmacology 2006;72(11):1367-74.
2006: Bastian Opitz; Maya Vinzing; Vincent van Laak; Bernd Schmeck; Guido Heine; Stefan Günther; Robert Preissner; Hortense Slevogt; Philippe Dje N'Guessan; Julia Eitel; Torsten Goldmann; Antje Flieger; Norbert Suttorp; Stefan Hippenstiel
Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication.
The Journal of biological chemistry 2006;281(47):36173-9.
2006: Hortense Slevogt; Bernd Schmeck; Carola Jonatat; Janine Zahlten; Wiebke Beermann; Vincent van Laak; Bastian Opitz; Solveig Dietel; Philippe Dje N'Guessan; Stefan Hippenstiel; Norbert Suttorp; Joachim Seybold
Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reduction.
American journal of physiology. Lung cellular and molecular physiology 2006;290(5):L818-26.
2006: Bernd Schmeck; Kerstin Moog; Janine Zahlten; Vincent van Laak; Philippe Dje N'Guessan; Bastian Opitz; Simone Rosseau; Norbert Suttorp; Stefan Hippenstiel
Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells.
Respiratory research 2006;7():98.
2006: Bastian Opitz; Andreas W Püschel; Wiebke Beermann; Andreas C Hocke; Stefanie Förster; Bernd Schmeck; Vincent van Laak; Trinad Chakraborty; Norbert Suttorp; Stefan Hippenstiel
Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):484-90.
2005: Bernd Schmeck; Wiebke Beermann; Vincent van Laak; Janine Zahlten; Bastian Opitz; Martin Witzenrath; Andreas C Hocke; Trinad Chakraborty; Michael Kracht; Simone Rosseau; Norbert Suttorp; Stefan Hippenstiel
Intracellular bacteria differentially regulated endothelial cytokine release by MAPK-dependent histone modification.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):2843-50.
2004: Bernd Schmeck; Janine Zahlten; Kerstin Moog; Vincent van Laak; Sylvia Huber; Andreas C Hocke; Bastian Opitz; Elke Hoffmann; Michael Kracht; Jens Zerrahn; Sven Hammerschmidt; Simone Rosseau; Norbert Suttorp; Stefan Hippenstiel
Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor.
The Journal of biological chemistry 2004;279(51):53241-7.