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Irene van Langen

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Karin Y van Spaendonck-Zwarts; Arthur A M Wilde; Folkert W Asselbergs; Imke Christiaans; Rudolf A de Boer; Jan D H Jongbloed; Ronald H Lekanne Deprez; Yigal M Pinto; Jan G Post; Maarten P van den Berg; Irene M van Langen; Anneke M van Mil; Ingrid A W van Rijsingen; J Peter van Tintelen
Genetic analysis in 418 index patients with idiopathic dilated cardiomyopathy: overview of 10 years' experience.
Jan J J Aalberts; Agnes G Schuurman; Chris H L Thio; Bert A E van der Pol; Irene M van Langen; J Peter van Tintelen; Maarten P van den Berg
Diagnostic yield in adults screened at the Marfan outpatient clinic using the 1996 and 2010 Ghent nosologies.
Abdennasser Bardai; Jocelyn Berdowski; Christian van der Werf; Marieke T Blom; Manon Ceelen; Irene M van Langen; Jan G P Tijssen; Arthur A M Wilde; Rudolph W Koster; Hanno L Tan
Incidence, causes, and outcomes of out-of-hospital cardiac arrest in children. A comprehensive, prospective, population-based study in the Netherlands.

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All Publications

2013: Karin Y van Spaendonck-Zwarts; Arthur A M Wilde; Folkert W Asselbergs; Imke Christiaans; Rudolf A de Boer; Jan D H Jongbloed; Ronald H Lekanne Deprez; Yigal M Pinto; Jan G Post; Maarten P van den Berg; Irene M van Langen; Anneke M van Mil; Ingrid A W van Rijsingen; J Peter van Tintelen
Genetic analysis in 418 index patients with idiopathic dilated cardiomyopathy: overview of 10 years' experience.
European journal of heart failure 2013;15(6):628-36.
2012: Jan J J Aalberts; Agnes G Schuurman; Chris H L Thio; Bert A E van der Pol; Irene M van Langen; J Peter van Tintelen; Maarten P van den Berg
Diagnostic yield in adults screened at the Marfan outpatient clinic using the 1996 and 2010 Ghent nosologies.
American journal of medical genetics. Part A 2012;158A(5):982-8.
2011: Abdennasser Bardai; Jocelyn Berdowski; Christian van der Werf; Marieke T Blom; Manon Ceelen; Irene M van Langen; Jan G P Tijssen; Arthur A M Wilde; Rudolph W Koster; Hanno L Tan
Incidence, causes, and outcomes of out-of-hospital cardiac arrest in children. A comprehensive, prospective, population-based study in the Netherlands.
Journal of the American College of Cardiology 2011;57(18):1822-8.
2011: Imke Christiaans; Erwin Birnie; Gouke J Bonsel; marcel mannens; Michelle Michels; Daniëlle Majoor-Krakauer; Dennis Dooijes; J Peter van Tintelen; Maarten P van den Berg; Paul G A Volders; Yvonne H Arens; Arthur van den Wijngaard; Douwe E Atsma; Apollonia T J M Helderman-van den Enden; Arjan C Houweling; Karin de Boer; Jasper J van der Smagt; Richard N W Hauer; Carlo L M Marcelis; Janneke Timmermans; Irene M van Langen; Arthur A M Wilde
Manifest disease, risk factors for sudden cardiac death, and cardiac events in a large nationwide cohort of predictively tested hypertrophic cardiomyopathy mutation carriers: determining the best cardiological screening strategy.
European heart journal 2011;32(9):1161-70.
2011: Anneke Hendrix; C Jan Willem Borleffs; Aryan Vink; Pieter A Doevendans; Arthur A Wilde; Irene M van Langen; Jasper J van der Smagt; Michiel L Bots; Arend Mosterd
Cardiogenetic screening of first-degree relatives after sudden cardiac death in the young: a population-based approach.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2011;13(5):716-22.
2010: Christian van der Werf; Nynke Hofman; Hanno L Tan; Pascal F H M van Dessel; Marielle Alders; Allard C van der Wal; Irene M van Langen; Arthur A M Wilde
Diagnostic yield in sudden unexplained death and aborted cardiac arrest in the young: the experience of a tertiary referral center in The Netherlands.
Heart rhythm : the official journal of the Heart Rhythm Society 2010;7(10):1383-9.
2010: Ellen Otten; Angeliki Asimaki; Alexander Maass; Irene M van Langen; Allard van der Wal; Nicolaas de Jonge; Maarten P van den Berg; Jeffrey E Saffitz; Arthur A M Wilde; Jan D H Jongbloed; J Peter van Tintelen
Desmin mutations as a cause of right ventricular heart failure affect the intercalated disks.
Heart rhythm : the official journal of the Heart Rhythm Society 2010;7(8):1058-64.
2010: Nynke Hofman; Hanno L Tan; Marielle Alders; Irene M van Langen; Arthur A M Wilde
Active cascade screening in primary inherited arrhythmia syndromes: does it lead to prophylactic treatment?
Journal of the American College of Cardiology 2010;55(23):2570-6.
2010: A Hendrix; C van der Werf; Michiel Bots; E Birnie; Jasper J van der Smagt; C J W Borleffs; Aryan Vink; H C van Weert; P A F M Doevendans; A A M Wilde; Arend Mosterd; Irene M van Langen
Rationale and design of the CAREFUL study : The yield of CARdiogenetic scrEening in First degree relatives of sudden cardiac and UnexpLained death victims <45 years.
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 2010;18(6):286-90.
2010: I Christiaans; E A Nannenberg; Dennis Dooijes; R J E Jongbloed; M Michels; P G Postema; D Majoor-Krakauer; A van den Wijngaard; M M A M Mannens; J Peter van Tintelen; Irene M van Langen; A A M Wilde
Founder mutations in hypertrophic cardiomyopathy patients in the Netherlands.
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 2010;18(5):248-54.
2010: Imke Christiaans; Erwin Birnie; Irene M van Langen; Karin Y van Spaendonck-Zwarts; J Peter van Tintelen; Maarten P van den Berg; Douwe E Atsma; Apollonia T J M Helderman-van den Enden; Yigal M Pinto; J F Hermans-van Ast; Gouke J Bonsel; Arthur A M Wilde
The yield of risk stratification for sudden cardiac death in hypertrophic cardiomyopathy myosin-binding protein C gene mutation carriers: focus on predictive screening.
European heart journal 2010;31(7):842-8.
2010: Christian van der Werf; Irene M van Langen; Arthur A M Wilde
Sudden death in the young: what do we know about it and how to prevent?
Circulation. Arrhythmia and electrophysiology 2010;3(1):96-104.
2010: Imke Christiaans; Tjitske M Kok; Irene M van Langen; Erwin Birnie; Gouke J Bonsel; Arthur A M Wilde; Ellen M A Smets
Obtaining insurance after DNA diagnostics: a survey among hypertrophic cardiomyopathy mutation carriers.
European journal of human genetics : EJHG 2010;18(2):251-3.
2009: J T Vehmeijer; I Christiaans; Irene M van Langen; Erwin Birnie; G J Bonsel; E M A Smets; A A M Wilde
Risk stratification for sudden cardiac death in hypertrophic cardiomyopathy: Dutch cardiologists and the care of mutation carriers.
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 2009;17(12):464-9.
2009: Imke Christiaans; Ronald H Lekanne dit Deprez; Irene M van Langen; Arthur A M Wilde
Ventricular fibrillation in MYH7-related hypertrophic cardiomyopathy before onset of ventricular hypertrophy.
Heart rhythm : the official journal of the Heart Rhythm Society 2009;6(9):1366-9.
2009: Imke Christiaans; Irene M van Langen; Erwin Birnie; Gouke J Bonsel; Arthur A M Wilde; Ellen M A Smets
Genetic counseling and cardiac care in predictively tested hypertrophic cardiomyopathy mutation carriers: the patients' perspective.
American journal of medical genetics. Part A 2009;149A(7):1444-51.
2009: Imke Christiaans; Irene M van Langen; Erwin Birnie; Gouke J Bonsel; Arthur A M Wilde; Ellen M A Smets
Quality of life and psychological distress in hypertrophic cardiomyopathy mutation carriers: a cross-sectional cohort study.
American journal of medical genetics. Part A 2009;149A(4):602-12.
2008: Tineke M Meulenkamp; Aad Tibben; Eline D Mollema; Irene M van Langen; Albert Wiegman; Guido M de Wert; Inez D de Beaufort; Arthur A M Wilde; Ellen M A Smets
Predictive genetic testing for cardiovascular diseases: impact on carrier children.
American journal of medical genetics. Part A 2008;146A(24):3136-46.
2008: Imke Christiaans; Erwin Birnie; Gouke J Bonsel; Arthur A M Wilde; Irene M van Langen
Uptake of genetic counselling and predictive DNA testing in hypertrophic cardiomyopathy.
European journal of human genetics : EJHG 2008;16(10):1201-7.
2008: Sam de la Fuente; Irene M van Langen; Alex V Postma; Henni Bikker; Albert Meijer
A case of catecholaminergic polymorphic ventricular tachycardia caused by two calsequestrin 2 mutations.
Pacing and clinical electrophysiology : PACE 2008;31(7):916-9.
2008: Karin S W H Hendriks; Margriet M W B Hendriks; Erwin Birnie; F J M Grosfeld; Arthur A M Wilde; Jan van den Bout; Ellen M A Smets; J Peter van Tintelen; Herman F J ten Kroode; Irene M van Langen
Familial disease with a risk of sudden death: a longitudinal study of the psychological consequences of predictive testing for long QT syndrome.
Heart rhythm : the official journal of the Heart Rhythm Society 2008;5(5):719-24.
2008: Ellen M A Smets; Marinka M H Stam; Tineke M Meulenkamp; Irene M van Langen; Arthur A M Wilde; Albert Wiegman; Guido M de Wert; Aad Tibben
Health-related quality of life of children with a positive carrier status for inherited cardiovascular diseases.
American journal of medical genetics. Part A 2008;146A(6):700-7.
2007: J Kodde; Nynke Hofman; C L A Reichert; Irene M van Langen; A A M Wilde
Cardiogenetic counselling in a non-university hospital.
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 2007;15(12):412-4.
2007: J Peter van Tintelen; Robert M W Hofstra; Hilga katerberg; Tom Rossenbacker; Ans C P Wiesfeld; Gideon J Du Marchie Sarvaas; Arthur A M Wilde; Irene M van Langen; Eline A Nannenberg; Anneke J van der Kooi; Marian Kraak; Isabelle C Van Gelder; Dirk Jan van Veldhuisen; Yvonne J Vos; Maarten P van den Berg
High yield of LMNA mutations in patients with dilated cardiomyopathy and/or conduction disease referred to cardiogenetics outpatient clinics.
American heart journal 2007;154(6):1130-9.
2007: Zahurul A Bhuiyan; Maarten P van den Berg; J Peter van Tintelen; Margreet Th E Bink-Boelkens; Ans C P Wiesfeld; Marielle Alders; Alex V Postma; Irene M van Langen; marcel mannens; Arthur A M Wilde
Expanding spectrum of human RYR2-related disease: new electrocardiographic, structural, and genetic features.
Circulation 2007;116(14):1569-76.
2007: Nynke Hofman; Hanno L Tan; Sally-Ann Barker Clur; Marielle Alders; Irene M van Langen; Arthur A M Wilde
Contribution of inherited heart disease to sudden cardiac death in childhood.
Pediatrics 2007;120(4):e967-73.
2007: Nynke Hofman; P G Postema; Irene M van Langen; E A Nannenberg; Marielle Alders; Roselie J Jongbloed; H J M Smeets; Arthur A M Wilde
[Genetic identification of patients and families with a long-QT syndrome: large regional differences in the result of 10 years].
Nederlands tijdschrift voor geneeskunde 2007;151(11):644-8.
2007: Nynke Hofman; Arthur A M Wilde; Stefan Kääb; Irene M van Langen; Michael W T Tanck; marcel mannens; Martin Hinterseer; britt beckmann; Hanno L Tan
Diagnostic criteria for congenital long QT syndrome in the era of molecular genetics: do we need a scoring system?
European heart journal 2007;28(5):575-80.
2006: Irene M van Langen; Arthur A M Wilde
Con: Newborn screening to prevent sudden cardiac death?
Heart rhythm : the official journal of the Heart Rhythm Society 2006;3(11):1356-9.
2006: J Peter van Tintelen; Mark M Entius; Zahurul A Bhuiyan; Roselie J Jongbloed; Ans C P Wiesfeld; Arthur A M Wilde; Jasper van der Smagt; Ludolf G Boven; marcel mannens; Irene M van Langen; Robert M W Hofstra; Luuk C Otterspoor; Pieter A Doevendans; Luz-Maria Rodriguez; Isabelle C Van Gelder; Richard N W Hauer
Plakophilin-2 mutations are the major determinant of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Circulation 2006;113(13):1650-8.
2005: Karin S W H Hendriks; F J M Grosfeld; J Peter van Tintelen; Irene M van Langen; Arthur A M Wilde; Jan van den Bout; Herman F J ten Kroode
Can parents adjust to the idea that their child is at risk for a sudden death?: Psychological impact of risk for long QT syndrome.
American journal of medical genetics. Part A 2005;138A(2):107-12.
2005: Irene M van Langen; Erwin Birnie; E Schuurman; Hanno L Tan; Nynke Hofman; Gouke J Bonsel; Arthur A M Wilde
Preferences of cardiologists and clinical geneticists for the future organization of genetic care in hypertrophic cardiomyopathy: a survey.
Clinical genetics 2005;68(4):360-8.
2005: Arthur A M Wilde; Irene M van Langen; marcel mannens; Reinier A Waalewijn; A Maes
[Sudden death at young age and the importance of molecular-pathologic investigation].
Nederlands tijdschrift voor geneeskunde 2005;149(29):1601-4.
2005: Hanno L Tan; Nynke Hofman; Irene M van Langen; Allard C van der Wal; Arthur A M Wilde
Sudden unexplained death: heritability and diagnostic yield of cardiological and genetic examination in surviving relatives.
Circulation 2005;112(2):207-13.
2005: Karin S W H Hendriks; F J M Grosfeld; Arthur A M Wilde; Jan van den Bout; Irene M van Langen; J Peter van Tintelen; Herman F J ten Kroode
High distress in parents whose children undergo predictive testing for long QT syndrome.
Community genetics 2005;8(2):103-13.
2004: Irene M van Langen; Nynke Hofman; Hanno L Tan; Arthur A M Wilde
Family and population strategies for screening and counselling of inherited cardiac arrhythmias.
Annals of medicine 2004;36 Suppl 1():116-24.
2003: Marielle Alders; Roselie J Jongbloed; Wout Deelen; Arthur van den Wijngaard; Pieter A Doevendans; Folkert J Ten Cate; Vera Regitz-Zagrosek; Hans-Peter Vosberg; Irene M van Langen; Arthur Wilde; Dennis Dooijes; marcel mannens
The 2373insG mutation in the MYBPC3 gene is a founder mutation, which accounts for nearly one-fourth of the HCM cases in the Netherlands.
European heart journal 2003;24(20):1848-53.
2003: Irene M van Langen; Erwin Birnie; Nico J Leschot; Gouke J Bonsel; Arthur A M Wilde
Genetic knowledge and counselling skills of Dutch cardiologists: sufficient for the genomics era?
European heart journal 2003;24(6):560-6.
2003: Irene M van Langen; Erwin Birnie; Marielle Alders; Roselie J Jongbloed; H Le Marec; Arthur A M Wilde
The use of genotype-phenotype correlations in mutation analysis for the long QT syndrome.
Journal of medical genetics 2003;40(2):141-5.
2003: W Antoinette Groenewegen; Mehran Firouzi; Connie R Bezzina; Saskia Vliex; Irene M van Langen; Lodewijk A Sandkuijl; Jeroen P P Smits; Miriam Hulsbeek; Martin B Rook; Habo J Jongsma; Arthur A M Wilde
A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill.
Circulation research 2003;92(1):14-22.
2002: Chantal E Conrath; Arthur A M Wilde; Roselie J Jongbloed; Marielle Alders; Irene M van Langen; J Peter van Tintelen; Pieter A Doevendans; Tobias Opthof
Gender differences in the long QT syndrome: effects of beta-adrenoceptor blockade.
Cardiovascular research 2002;53(3):770-6.
2001: Maarten P van den Berg; Arthur A M Wilde; Jan Brouwer; Jaap Haaksma; Annemarie H Van Der Hout; I Stolte-Dijkstra; Irene M van Langen; Gertie C M Beaufort-Krol; Jan Hein Cornel; Harry J G M Crijns
Possible bradycardic mode of death and successful pacemaker treatment in a large family with features of long QT syndrome type 3 and Brugada syndrome.
Journal of cardiovascular electrophysiology 2001;12(6):630-6.
2000: Herman F J ten Kroode; Irene M van Langen; Karin S W H Hendriks; J Peter van Tintelen; F J M Grosfeld; Arthur A M Wilde
[Long QT-interval syndrome and investigation of heritability: psychological reactions in three generations in one family].
Nederlands tijdschrift voor geneeskunde 2000;144(21):995-9.
1999: Connie R Bezzina; Marieke W Veldkamp; Maarten P van den Berg; Alex V Postma; Martin B Rook; J W Viersma; Irene M van Langen; G Tan-Sindhunata; Margreet Th E Bink-Boelkens; Annemarie H Van Der Hout; marcel mannens; Arthur A M Wilde
A single Na(+) channel mutation causing both long-QT and Brugada syndromes.
Circulation research 1999;85(12):1206-13.
1999: Arthur A M Wilde; Irene M van Langen; J Peter van Tintelen; R N Hauer
[Presymptomatic screening after a sudden cardiac death in the family].
Nederlands tijdschrift voor geneeskunde 1999;143(32):1643-8.
1999: Arthur A M Wilde; Roselie J Jongbloed; Pieter A Doevendans; D R Düren; Richard N W Hauer; Irene M van Langen; J Peter van Tintelen; H J M Smeets; H Meyer; JL Geelen
Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1).
Journal of the American College of Cardiology 1999;33(2):327-32.
1999: Roselie J Jongbloed; Arthur A M Wilde; JL Geelen; Pieter A Doevendans; C Schaap; Irene M van Langen; J Peter van Tintelen; JM Cobben; Gertie C M Beaufort-Krol; Joep P M Geraedts; H J M Smeets
Novel KCNQ1 and HERG missense mutations in Dutch long-QT families.
Human mutation 1999;13(4):301-10.
1998: Irene M van Langen; Arthur A M Wilde; marcel mannens
[Sudden death in young men due to arrhythmogenic right ventricular dysplasia].
Nederlands tijdschrift voor geneeskunde 1998;142(13):739-40.
1997: Irene M van Langen; Cora M Aalfs; E M Smets; J C de Haes; M C Jansweijer; Nico J Leschot
[Genetic counseling: should side issues become main issues?].
Nederlands tijdschrift voor geneeskunde 1997;141(38):1801-4.