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Fijs van Leeuwen

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Nynke S van den Berg; Henk G van der Poel; Renato A Valdés Olmos; Fijs W B van Leeuwen
Sentinel lymph node biopsy for prostate cancer: a hybrid approach.
Patrick T K Chin; Celso de Mello Donega; Albert J R Heck; Abraham Koster; Marcus T M Rood; Marte van der Linden; Elleke J van Harten; Fijs W B van Leeuwen; Arjan Barendregt; Andries Meijerink
Enhanced luminescence of Ag nanoclusters via surface modification.
Tessa Buckle; Anton Bunschoten; Jos Jonkers; Lee Josephson; Joeri Kuil; Hildo J Lamb; Nynke S van den Berg; Alexander D Borowsky; Hushan Yuan; Fijs W B van Leeuwen
Use of a single hybrid imaging agent for integration of target validation with in vivo and ex vivo imaging of mouse tumor lesions resembling human DCIS.

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2013: Nynke S van den Berg; Henk G van der Poel; Renato A Valdés Olmos; Fijs W B van Leeuwen
Sentinel lymph node biopsy for prostate cancer: a hybrid approach.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013;54(4):493-6.
2013: Patrick T K Chin; Celso de Mello Donega; Albert J R Heck; Abraham Koster; Marcus T M Rood; Marte van der Linden; Elleke J van Harten; Fijs W B van Leeuwen; Arjan Barendregt; Andries Meijerink
Enhanced luminescence of Ag nanoclusters via surface modification.
Nanotechnology 2013;24(7):075703.
2013: Tessa Buckle; Anton Bunschoten; Jos Jonkers; Lee Josephson; Joeri Kuil; Hildo J Lamb; Nynke S van den Berg; Alexander D Borowsky; Hushan Yuan; Fijs W B van Leeuwen
Use of a single hybrid imaging agent for integration of target validation with in vivo and ex vivo imaging of mouse tumor lesions resembling human DCIS.
PloS one 2013;8(1):e48324.
2012: Floris P R Verbeek; Cornelis J H van de Velde; Joost R van der Vorst; Fijs W B van Leeuwen; BA Bonsing; John V Frangioni; Merlijn Hutteman; Boudewijn E Schaafsma; Rutger-Jan Swijnenburg; Alexander L Vahrmeijer
Image-guided hepatopancreatobiliary surgery using near-infrared fluorescent light.
Journal of hepato-biliary-pancreatic sciences 2012;19(6):626-37.
2012: Paula van Tijn; Frank J A Dennissen; Romina J G Gentier; Denise Hermes; Barbara Hobo; Harry W M Steinbusch; Fijs W B van Leeuwen; David F Fischer
Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer's disease.
Neurochemistry international 2012;61(5):739-48.
2012: Joeri Kuil; Tessa Buckle; Fijs W B van Leeuwen
Imaging agents for the chemokine receptor 4 (CXCR4).
Chemical Society reviews 2012;41(15):5239-61.
2012: Oscar R Brouwer; Tessa Buckle; Simon Horenblas; W Martin C Klop; Omgo E Nieweg; Henk G van der Poel; Fijs W B van Leeuwen; Bas W van Rhijn; Lenka Vermeeren; Alfons J M Balm; Renato A Valdés Olmos
Comparing the hybrid fluorescent-radioactive tracer indocyanine green-99mTc-nanocolloid with 99mTc-nanocolloid for sentinel node identification: a validation study using lymphoscintigraphy and SPECT/CT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012;53(7):1034-40.
2012: Tessa Buckle; Renato A Valdés Olmos; Henk G van der Poel; Oscar R Brouwer; Fijs W B van Leeuwen
Relationship between intraprostatic tracer deposits and sentinel lymph node mapping in prostate cancer patients.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012;53(7):1026-33.
2012: Nynke S van den Berg; Michiel W M van den Brekel; Charlotte L Zuur; Alfons J M Balm; Oscar R Brouwer; Bariş Karakullukcu; W Martin C Klop; I Bing Tan; Renato A Valdés Olmos; Fijs W B van Leeuwen
Concomitant radio- and fluorescence-guided sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity using ICG-(99m)Tc-nanocolloid.
European journal of nuclear medicine and molecular imaging 2012;39(7):1128-36.
2012: Oscar R Brouwer; Tessa Buckle; W Martin C Klop; Omgo E Nieweg; Renato A Valdés Olmos; Michiel W M van den Brekel; Alfons J M Balm; Lenka Vermeeren; Fijs W B van Leeuwen
Feasibility of sentinel node biopsy in head and neck melanoma using a hybrid radioactive and fluorescent tracer.
Annals of surgical oncology 2012;19(6):1988-94.
2012: Oscar R Brouwer; Tessa Buckle; Anton Bunschoten; Joeri Kuil; Alexander L Vahrmeijer; Renato A Valdés Olmos; Henk G van der Poel; Thomas Wendler; Fijs W B van Leeuwen
Image navigation as a means to expand the boundaries of fluorescence-guided surgery.
Physics in medicine and biology 2012;57(10):3123-36.
2012: Anton Bunschoten; Lee Josephson; Joeri Kuil; Alexander L Vahrmeijer; Nils L Visser; Hushan Yuan; Tessa Buckle; Fijs W B van Leeuwen
Multimodal interventional molecular imaging of tumor margins and distant metastases by targeting αvβ3 integrin.
Chembiochem : a European journal of chemical biology 2012;13(7):1039-45.
2012: Nynke S van den Berg; Fijs W B van Leeuwen; Henk G van der Poel
Fluorescence guidance in urologic surgery.
Current opinion in urology 2012;22(2):109-20.
2012: Peter Steunenberg; Nynke S van den Berg; Fijs W B van Leeuwen; Tessa Buckle; Joeri Kuil; Albert Ruggi; Aldrik H Velders
Phosphorescence imaging of living cells with amino acid-functionalized tris(2-phenylpyridine)iridium(III) complexes.
Inorganic chemistry 2012;51(4):2105-14.
2012: Anton Bunschoten; Joeri Kuil; Gary D Luker; Kathryn E Luker; Omgo E Nieweg; Tessa Buckle; Fijs W B van Leeuwen
Targeted non-covalent self-assembled nanoparticles based on human serum albumin.
Biomaterials 2012;33(3):867-75.
2011: Joeri Kuil; Joppe Oldenburg; Alexander D Borowsky; Tessa Buckle; Lee Josephson; Hushan Yuan; Fijs W B van Leeuwen
Hybrid peptide dendrimers for imaging of chemokine receptor 4 (CXCR4) expression.
Molecular pharmaceutics 2011;8(6):2444-53.
2011: Henk G van der Poel; Oscar R Brouwer; Tessa Buckle; Renato A Valdés Olmos; Fijs W B van Leeuwen
Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer.
European urology 2011;60(4):826-33.
2011: Joeri Kuil; Joppe Oldenburg; Peter Steunenberg; Patrick T K Chin; Kees Jalink; Aldrik H Velders; Fijs W B van Leeuwen
Peptide-functionalized luminescent iridium complexes for lifetime imaging of CXCR4 expression.
Chembiochem : a European journal of chemical biology 2011;12(12):1897-903.
2011: Joeri Kuil; Tessa Buckle; Hushan Yuan; Nynke S van den Berg; Shinya Oishi; Nobutaka Fujii; Lee Josephson; Fijs W B van Leeuwen
Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide.
Bioconjugate chemistry 2011;22(5):859-64.
2011: Constantin Ungureanu; Rene Kroes; Wilma Petersen; Tom A M Groothuis; Felicia Ungureanu; Hans Janssen; Fijs W B van Leeuwen; Rob P H Kooyman; Srirang Manohar; Ton G van Leeuwen
Light interactions with gold nanorods and cells: implications for photothermal nanotherapeutics.
Nano letters 2011;11(5):1887-94.
2011: Chantal A C Beekman; Tessa Buckle; Anne C van Leeuwen; Renato A Valdés Olmos; Marcel Verheij; Sven Rottenberg; Fijs W B van Leeuwen
Questioning the value of (99m)Tc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2011;69(4):656-62.
2011: Albert Ruggi; Chantal Beekman; Dorothee Wasserberg; Vinod Subramaniam; David N Reinhoudt; Fijs W B van Leeuwen; Aldrik H Velders
Dendritic ruthenium(II)-based dyes tuneable for diagnostic or therapeutic applications.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(2):464-7.
2011: Anne C van Leeuwen; Tessa Buckle; Gavin Bendle; Lenka Vermeeren; Renato Valdés Olmos; Henk G van de Poel; Fijs W B van Leeuwen
Tracer-cocktail injections for combined pre- and intraoperative multimodal imaging of lymph nodes in a spontaneous mouse prostate tumor model.
Journal of biomedical optics 2011;16(1):016004.
2010: Tessa Buckle; Patrick T K Chin; Fijs W B van Leeuwen
(Non-targeted) radioactive/fluorescent nanoparticles and their potential in combined pre- and intraoperative imaging during sentinel lymph node resection.
Nanotechnology 2010;21(48):482001.
2010: Fijs W B van Leeuwen; Tessa Buckle; Lukas Batteau; Bert Pool; Michiel Sinaasappel; Jos Jonkers; Kenneth G A Gilhuijs
Potential value of color-coded dynamic breast-specific gamma-imaging; comparing (99m)Tc-(V)-DMSA, (99m)Tc-MIBI, and (99m)Tc-HDP in a mouse mammary tumor model.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2010;68(12):2117-24.
2010: Joeri Kuil; Aldrik H Velders; Fijs W B van Leeuwen
Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label.
Bioconjugate chemistry 2010;21(10):1709-19.
2010: Tessa Buckle; Anne C van Leeuwen; Patrick T K Chin; Hans Janssen; Sara H Muller; Jos Jonkers; Fijs W B van Leeuwen
A self-assembled multimodal complex for combined pre- and intraoperative imaging of the sentinel lymph node.
Nanotechnology 2010;21(35):355101.
2010: Tessa Buckle; Patrick T K Chin; Nynke S van den Berg; Claudette E Loo; Wim Koops; Kenneth G A Gilhuijs; Fijs W B van Leeuwen
Tumor bracketing and safety margin estimation using multimodal marker seeds: a proof of concept.
Journal of biomedical optics 2010;15(5):056021.
2010: Patrick T K Chin; Tessa Buckle; Arantxa Aguirre de Miguel; Stefan C J Meskers; René A J Janssen; Fijs W B van Leeuwen
Dual-emissive quantum dots for multispectral intraoperative fluorescence imaging.
Biomaterials 2010;31(26):6823-32.
2010: Raja G Rayavarapu; Wilma Petersen; Liesbeth Hartsuiker; Patrick Chin; Hans Janssen; Fijs W B van Leeuwen; Cees Otto; Srirang Manohar; Ton G van Leeuwen
In vitro toxicity studies of polymer-coated gold nanorods.
Nanotechnology 2010;21(14):145101.
2010: Remko de Pril; Barbara Hobo; Paula van Tijn; Raymund A C Roos; Fijs W B van Leeuwen; David F Fischer
Modest proteasomal inhibition by aberrant ubiquitin exacerbates aggregate formation in a Huntington disease mouse model.
Molecular and cellular neurosciences 2010;43(3):281-6.
2010: Tessa Buckle; Fijs W B van Leeuwen
Validation of intratracheal instillation of lung tumour cells in mice using single photon emission computed tomography/computed tomography imaging.
Laboratory animals 2010;44(1):40-5.
2009: Fijs W B van Leeuwen; Tessa Buckle; Ariena Kersbergen; Sven Rottenberg; Kenneth G A Gilhuijs
Noninvasive functional imaging of P-glycoprotein-mediated doxorubicin resistance in a mouse model of hereditary breast cancer to predict response, and assign P-gp inhibitor sensitivity.
European journal of nuclear medicine and molecular imaging 2009;36(3):406-12.
2007: Deborah J. Kuhn; Qing Chen; Peter M Voorhees; John S Strader; Kevin D Shenk; Congcong M Sun; Susan D Demo; Mark K Bennett; Fijs W B van Leeuwen; Asher Chanan-Khan; Robert Z Orlowski
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma.
Blood 2007;110(9):3281-90.
2007: Celia R Berkers; Fijs W B van Leeuwen; Tom A M Groothuis; Victor Peperzak; Erica W van Tilburg; Jannie Borst; Jacques Neefjes; Huib Ovaa
Profiling proteasome activity in tissue with fluorescent probes.
Molecular pharmaceutics 2007;4(5):739-48.
2007: Sven Rottenberg; Anders O H Nygren; Marina Pajic; Fijs W B van Leeuwen; Ingrid van der Heijden; Koen van de Wetering; Xiaoling Liu; Karin E de Visser; Kenneth G Gilhuijs; Olaf van Tellingen; Jan P Schouten; Jos Jonkers; Piet Borst
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12117-22.
2007: Paula van Tijn; Femke De Vrij; Karianne G Schuurman; Nico P Dantuma; David F Fischer; Fijs W B van Leeuwen; Elly M Hol
Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease.
Journal of cell science 2007;120(Pt 9):1615-23.
2007: Mark Kristiansen; Pelagia Deriziotis; Derek E Dimcheff; Graham S Jackson; Huib Ovaa; Heike Naumann; Anthony R Clarke; Fijs W B van Leeuwen; Victoria Menéndez-Benito; Nico P Dantuma; John L Portis; John Collinge; Sarah J Tabrizi
Disease-associated prion protein oligomers inhibit the 26S proteasome.
Molecular cell 2007;26(2):175-88.
2007: Tamar Evan-Salem; Limor Frish; Fijs W B van Leeuwen; David N Reinhoudt; Willem Verboom; Mark S Kaucher; Jeffery T Davis; Yoram Cohen
Self-assembled ionophores from isoguanosine: diffusion NMR spectroscopy clarifies cation's and anion's influence on supramolecular structure.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(7):1969-77.
2007: Remko de Pril; David F Fischer; Raymund A C Roos; Fijs W B van Leeuwen
Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases.
Molecular and cellular neurosciences 2007;34(1):10-9.
2006: Martijn Verdoes; Bogdan I Florea; Victoria Menendez-Benito; Christa Maynard; Martin D Witte; Wouter A van der Linden; Adrianus M C H van den Nieuwendijk; Tanja Hofmann; Celia R Berkers; Fijs W B van Leeuwen; Tom A M Groothuis; Michiel A Leeuwenburgh; Huib Ovaa; Jacques Neefjes; Dmitri V Filippov; Gijsbert A van der Marel; Nico P Dantuma; Herman S Overkleeft
A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.
Chemistry & biology 2006;13(11):1217-26.
2006: Fijs W B van Leeuwen; J M Kros; W Kamphorst; C van Schravendijk; Rob A I de Vos
Molecular misreading: the occurrence of frameshift proteins in different diseases.
Biochemical Society transactions 2006;34(Pt 5):738-42.
2006: David F Fischer; Elly M Hol; Barbara Hobo; Fijs W B van Leeuwen
Alzheimer-associated APP+1 transgenic mice: frameshift beta-amyloid precursor protein is secreted in cerebrospinal fluid without inducing neuropathology.
Neurobiology of aging 2006;27(10):1445-50.
2006: Remko de Pril; David F Fischer; Fijs W B van Leeuwen
Conformational diseases: an umbrella for various neurological disorders with an impaired ubiquitin-proteasome system.
Neurobiology of aging 2006;27(4):515-23.
2006: Fijs W B van Leeuwen; P van Tijn; M A F Sonnemans; Barbara Hobo; D M A Mann; Christine Van Broeckhoven; Samir Kumar-Singh; Patrick Cras; Geneviève Leuba; Armand Savioz; Marion L C Maat-Schieman; Haruyasu Yamaguchi; J M Kros; Wouter Kamphorst; Elly M Hol; Rob A I de Vos; David F Fischer
Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies.
Neurology 2006;66(2 Suppl 1):S86-92.
2006: Fijs W B van Leeuwen; Elly M Hol; David F Fischer
Frameshift proteins in Alzheimer's disease and in other conformational disorders: time for the ubiquitin-proteasome system.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):319-25.
2005: Reinko F Roelofs; David F Fischer; Simone H Houtman; Jacqueline A Sluijs; Wendy Van Haren; Fijs W B van Leeuwen; Elly M Hol
Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton.
Glia 2005;52(4):289-300.
2005: Elly M Hol; Fijs W B van Leeuwen; David F Fischer
The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1.
Trends in molecular medicine 2005;11(11):488-95.
2005: Jessica M C A Kerckhoffs; Mattijs G J ten Cate; Miguel A Mateos-Timoneda; Fijs W B van Leeuwen; Bianca Snellink-Ruël; Anthony L Spek; Huub Kooijman; Mercedes Crego-Calama; David N Reinhoudt
Selective self-organization of guest molecules in self-assembled molecular boxes.
Journal of the American Chemical Society 2005;127(36):12697-708.
2005: David F Fischer; Renske van Dijk; Jacqueline A Sluijs; Suresh M Nair; Marco Racchi; Christiaan N Levelt; Fijs W B van Leeuwen; Elly M Hol
Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(11):1451-8.
2005: Fijs W B van Leeuwen; Willem Verboom; David N Reinhoudt
Selective extraction of naturally occurring radioactive Ra2+.
Chemical Society reviews 2005;34(9):753-61.
2005: Fijs W B van Leeuwen; Cornelis J H Miermans; Hans Beijleveld; Tanja Tomasberger; Jeffery T Davis; Willem Verboom; David N Reinhoudt
Selective removal of 226Ra2+ from gas-field-produced waters.
Environmental science & technology 2005;39(14):5455-9.
2005: Fijs W B van Leeuwen; Hans Beijleveld; Cornelis J H Miermans; Jurriaan Huskens; Willem Verboom; David N Reinhoudt
Ionizable (Thia)calix[4]crowns as highly selective 226Ra2+ ionophores.
Analytical chemistry 2005;77(14):4611-7.
2005: Fijs W B van Leeuwen; Hans Beijleveld; Aldrik H Velders; Jurriaan Huskens; Willem Verboom; David N Reinhoudt
Thiacalix[4]arene derivatives as radium ionophores: a study on the requirements for Ra2+ extraction.
Organic & biomolecular chemistry 2005;3(10):1993-2001.
2005: Lisya Gerez; Annett de Haan; Elly M Hol; David F Fischer; Fijs W B van Leeuwen; Harry van Steeg; Rob Benne
Molecular misreading: the frequency of dinucleotide deletions in neuronal mRNAs for beta-amyloid precursor protein and ubiquitin B.
Neurobiology of aging 2005;26(2):145-55.
2004: Fijs W B van Leeuwen; Willem Verboom; Xiaodong Shi; Jeffery T Davis; David N Reinhoudt
Selective 226Ra2+ ionophores provided by self-assembly of guanosine and isoguanosine derivatives.
Journal of the American Chemical Society 2004;126(50):16575-81.
2004: Femke De Vrij; David F Fischer; Fijs W B van Leeuwen; Elly M Hol
Protein quality control in Alzheimer's disease by the ubiquitin proteasome system.
Progress in neurobiology 2004;74(5):249-70.
2004: P Fratta; W King Engel; Fijs W B van Leeuwen; Elly M Hol; Gaetano Vattemi; Valerie Askanas
Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers.
Neurology 2004;63(6):1114-7.
2004: Remko de Pril; David F Fischer; Marion L C Maat-Schieman; Barbara Hobo; Rob A I de Vos; Ewout R Brunt; Elly M Hol; Raymund A C Roos; Fijs W B van Leeuwen
Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases.
Human molecular genetics 2004;13(16):1803-13.
2004: Renske van Dijk; David F Fischer; Jacqueline A Sluijs; M A F Sonnemans; Barbara Hobo; L Mercken; D M A Mann; Elly M Hol; Fijs W B van Leeuwen
Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta40.
Journal of neurochemistry 2004;90(3):712-23.
2004: Fijs W B van Leeuwen; Hans Beijleveld; Huub Kooijman; Anthony L Spek; Willem Verboom; David N Reinhoudt
Synthesis and conformational evaluation of p-tert-butylthiacalix[4]arene-crowns.
The Journal of organic chemistry 2004;69(11):3928-36.
2004: Fijs W B van Leeuwen
Neuropeptide research discloses part of the secrets of Alzheimer's disease neuropathogenesis: state of the art 2004.
Neuroscience letters 2004;361(1-3):124-7.
2004: Alart Mulder; Amela Juković; Fijs W B van Leeuwen; Huub Kooijman; Anthony L Spek; Jurriaan Huskens; David N Reinhoudt
Photocontrolled release and uptake of a porphyrin guest by dithienylethene-tethered beta-cyclodextrin host dimers.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(5):1114-23.
2003: Jessica M C A Kerckhoffs; Fijs W B van Leeuwen; Anthony L Spek; Huub Kooijman; Mercedes Crego-Calama; David N Reinhoudt
Regulatory strategies in the complexation and release of a noncovalent guest trimer by a self-assembled molecular cage.
Angewandte Chemie (International ed. in English) 2003;42(46):5717-22.
2003: David F Fischer; Rob A I de Vos; Renske van Dijk; Femke De Vrij; Evelien A Proper; M A F Sonnemans; Marian C Verhage; Jacqueline A Sluijs; Barbara Hobo; Mohamed Zouambia; Ernst N H Jansen Steur; Wouter Kamphorst; Elly M Hol; Fijs W B van Leeuwen
Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2014-24.
2003: Elly M Hol; Renske van Dijk; Lisya Gerez; Jacqueline A Sluijs; Barbara Hobo; Martijn T Tonk; Annett de Haan; Wouter Kamphorst; David F Fischer; Rob Benne; Fijs W B van Leeuwen
Frameshifted beta-amyloid precursor protein (APP+1) is a secretory protein, and the level of APP+1 in cerebrospinal fluid is linked to Alzheimer pathology.
The Journal of biological chemistry 2003;278(41):39637-43.
2003: Elly M Hol; R F Roelofs; E Moraal; M A F Sonnemans; Jacqueline A Sluijs; Evelien A Proper; P N E De Graan; David F Fischer; Fijs W B van Leeuwen
Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms.
Molecular psychiatry 2003;8(9):786-96.
2003: Andrew D Hope; Rohan de Silva; David F Fischer; Elly M Hol; Fijs W B van Leeuwen; Andrew J Lees
Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression.
Journal of neurochemistry 2003;86(2):394-404.
2003: Fawzia Bardag-Gorce; Nora E Riley; Victoria Nguyen; Rosalyn O Montgomery; Barbara A French; Jun Li; Fijs W B van Leeuwen; W Lungo; Laron McPhaul; Samuel W French
The mechanism of cytokeratin aggresome formation: the role of mutant ubiquitin (UBB+1).
Experimental and molecular pathology 2003;74(2):160-7.
2002: Fijs W B van Leeuwen; Lisya Gerez; Rob Benne; Elly M Hol
+1 Proteins and aging.
The international journal of biochemistry & cell biology 2002;34(11):1502-5.
2002: Fawzia Bardag-Gorce; Fijs W B van Leeuwen; Victoria Nguyen; Barbara A French; Jun Li; Nora E Riley; Laron McPhaul; Yanhe Lue; Samuel W French
The role of the ubiquitin-proteasome pathway in the formation of mallory bodies.
Experimental and molecular pathology 2002;73(2):75-83.
2002: Laron McPhaul; Jun Wang; Elly M Hol; M A F Sonnemans; Nora E Riley; Victoria Nguyen; Qi X Yuan; Yanhe Lue; Fijs W B van Leeuwen; Samuel W French
Molecular misreading of the ubiquitin B gene and hepatic mallory body formation.
Gastroenterology 2002;122(7):1878-85.
2002: Sandy S Wu; Jean-Pierre de Chadarevian; Laron McPhaul; Nora E Riley; Fijs W B van Leeuwen; Samuel W French
Coexpression and accumulation of ubiquitin +1 and ZZ proteins in livers of children with alpha(1)-antitrypsin deficiency.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2002;5(3):293-8.
2002: Kristina Lindsten; Femke De Vrij; Lisette G G C Verhoef; David F Fischer; Fijs W B van Leeuwen; Elly M Hol; Maria Masucci; Nico P Dantuma
Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation.
The Journal of cell biology 2002;157(3):417-27.
2002: Z A Erkut; B A Th F Gabreëls; J Eikelenboom; Fijs W B van Leeuwen; Dick F Swaab
Glucocorticoid treatment is associated with decreased expression of processed AVP but not of proAVP, neurophysin or oxytocin in the human hypothalamus: are PC1 and PC2 involved?
Neuro endocrinology letters 2002;23(1):33-44.
2002: Nora E Riley; Jun Li; Simon Worrall; J A Rothnagel; C Swagell; Fijs W B van Leeuwen; Samuel W French
The Mallory body as an aggresome: in vitro studies.
Experimental and molecular pathology 2002;72(1):17-23.
2001: Femke De Vrij; Jacqueline A Sluijs; Luisa Gregori; David F Fischer; Wim T Hermens; Dmitry Goldgaber; Joost Verhaagen; Fijs W B van Leeuwen; Elly M Hol
Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2680-8.
2000: Fijs W B van Leeuwen; David F Fischer; D Kamel; Jacqueline A Sluijs; M A F Sonnemans; Rob Benne; Dick F Swaab; Ahmad Salehi; Elly M Hol
Molecular misreading: a new type of transcript mutation expressed during aging.
Neurobiology of aging 2000;21(6):879-91.
2000: Fijs W B van Leeuwen; Elly M Hol; R W Hermanussen; M A F Sonnemans; E Moraal; David F Fischer; D A Evans; K F Chooi; J Peter H Burbach; David Murphy
Molecular misreading in non-neuronal cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(11):1595-602.
2000: Fijs W B van Leeuwen; David F Fischer; Rob Benne; Elly M Hol
Molecular misreading. A new type of transcript mutation in gerontology.
Annals of the New York Academy of Sciences 2000;908():267-81.
1999: Fijs W B van Leeuwen; Elly M Hol
Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration.
Journal of neural transmission. Supplementum 1999;57():137-59.
1998: B A Th F Gabreëls; Dick F Swaab; D P de Kleijn; A Dean; N G Seidah; JW van de Loo; Wim J M Van De Ven; G J Martens; Fijs W B van Leeuwen
The vasopressin precursor is not processed in the hypothalamus of Wolfram syndrome patients with diabetes insipidus: evidence for the involvement of PC2 and 7B2.
The Journal of clinical endocrinology and metabolism 1998;83(11):4026-33.
1998: Fijs W B van Leeuwen; J P Burbach; Elly M Hol
Mutations in RNA: a first example of molecular misreading in Alzheimer's disease.
Trends in neurosciences 1998;21(8):331-5.
1998: B A Th F Gabreëls; Dick F Swaab; D P de Kleijn; N G Seidah; JW van de Loo; Wim J M Van De Ven; G J Martens; Fijs W B van Leeuwen
Attenuation of the polypeptide 7B2, prohormone convertase PC2, and vasopressin in the hypothalamus of some Prader-Willi patients: indications for a processing defect.
The Journal of clinical endocrinology and metabolism 1998;83(2):591-9.
1998: Fijs W B van Leeuwen; D P de Kleijn; H H van den Hurk; A Neubauer; M A F Sonnemans; Jacqueline A Sluijs; S Köycü; R D Ramdjielal; Ahmad Salehi; G J Martens; F G Grosveld; J Peter; H Burbach; Elly M Hol
Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients.
Science (New York, N.Y.) 1998;279(5348):242-7.
1998: Fijs W B van Leeuwen; R W H Verwer; H Spence; D A Evans; J P Burbach
The magnocellular neurons of the hypothalamo-neurohypophyseal system display remarkable neuropeptidergic phenotypes leading to novel insights in neuronal cell biology.
Progress in brain research 1998;119():115-26.
1998: Elly M Hol; A Neubauer; D P de Kleijn; Jacqueline A Sluijs; R D Ramdjielal; M A F Sonnemans; Fijs W B van Leeuwen
Dinucleotide deletions in neuronal transcripts: a novel type of mutation in non-familial Alzheimer's disease and Down syndrome patients.
Progress in brain research 1998;117():379-95.
1997: B A Th F Gabreëls; R W H Verwer; M A F Sonnemans; Arja A Sluiter; C W Ang; Fijs W B van Leeuwen
Lack of translation of normal 7B2 mRNA levels in hypothalamic mutant vasopressin cells of the homozygous Brattleboro rat.
Neuroscience letters 1997;239(1):5-8.
1997: Anthony J G D Holtmaat; Wim T Hermens; M A F Sonnemans; Roman J Giger; Fijs W B van Leeuwen; Michael Gordon Kaplitt; AB Oestreicher; Willem Hendrik Gispen; Joost Verhaagen
Adenoviral vector-mediated expression of B-50/GAP-43 induces alterations in the membrane organization of olfactory axon terminals in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(17):6575-86.
1997: C W Ang; C H Dotman; H Winkler; R Fischer-Colbrie; M A F Sonnemans; Fijs W B van Leeuwen
Specific expression of secretogranin II in magnocellular vasopressin neurons of the rat supraoptic and paraventricular nucleus in response to osmotic stimulation.
Brain research 1997;765(1):13-20.
1996: D A Evans; J P Burbach; Dick F Swaab; Fijs W B van Leeuwen
Mutant vasopressin precursors in the human hypothalamus: evidence for neuronal somatic mutations in man.
Neuroscience 1996;71(4):1025-30.
1995: L P Pu; Fijs W B van Leeuwen; H L Tracer; M A F Sonnemans; Y Peng Loh
Localization of vasopressin mRNA and immunoreactivity in pituicytes of pituitary stalk-transected rats after osmotic stimulation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10653-7.
1995: J Peter; H Burbach; Roger A H Adan; S J Lolait; Fijs W B van Leeuwen; E Mezey; Miklós Palkovits; Claude Barberis
Molecular neurobiology and pharmacology of the vasopressin/oxytocin receptor family.
Cellular and molecular neurobiology 1995;15(5):573-95.
1995: Roger A H Adan; Fijs W B van Leeuwen; M A F Sonnemans; M Brouns; Gloria E Hoffman; Joseph G Verbalis; J Peter H Burbach
Rat oxytocin receptor in brain, pituitary, mammary gland, and uterus: partial sequence and immunocytochemical localization.
Endocrinology 1995;136(9):4022-8.
1995: Roger A H Adan; Fijs W B van Leeuwen; M A F Sonnemans; Gloria E Hoffman; Joseph G Verbalis; J Peter H Burbach
The rat oxytocin receptor. cDNA cloning and immunocytochemical localization in brain, pituitary, mammary gland and uterus.
Advances in experimental medicine and biology 1995;395():345-6.
1995: Fijs W B van Leeuwen; S Chouham; J F Axelson; Dick F Swaab; F J Van Eerdenburg
Sex differences in the distribution of estrogen receptors in the septal area and hypothalamus of the domestic pig (Sus scrofa).
Neuroscience 1995;64(1):261-75.
1994: C J Boersma; Fijs W B van Leeuwen
Neuron-glia interactions in the release of oxytocin and vasopressin from the rat neural lobe: the role of opioids, other neuropeptides and their receptors.
Neuroscience 1994;62(4):1003-20.
1994: B A Th F Gabreëls; Dick F Swaab; N G Seidah; H L van Duijnhoven; Gerard J M Martens; Fijs W B van Leeuwen
Differential expression of the neuroendocrine polypeptide 7B2 in hypothalami of Prader-(Labhart)-Willi syndrome patients.
Brain research 1994;657(1-2):281-93.
1994: D A Evans; A A M Van Der Kleij; M A F Sonnemans; J Peter H Burbach; Fijs W B van Leeuwen
Frameshift mutations at two hotspots in vasopressin transcripts in post-mitotic neurons.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6059-63.
1994: C J Boersma; Fijs W B van Leeuwen
Technical aspects of opioid receptor localization: detection of opioid receptor proteins by immunocytochemistry or with a biotinylated dynorphin analog.
Journal of neuroscience methods 1994;51(2):217-27.
1994: C J Boersma; Chris W Pool; Joop J Van Heerikhuize; Fijs W B van Leeuwen
Characterization of opioid binding sites in the neural and intermediate lobe of the rat pituitary gland by quantitative receptor autoradiography.
Journal of neuroendocrinology 1994;6(1):47-56.
1994: Fijs W B van Leeuwen; D A Evans; R Meloen; M A F Sonnemans
Differential neurophysin immunoreactivities in solitary magnocellular neurons of the homozygous Brattleboro rat indicate an altered neurophysin moiety.
Brain research 1994;635(1-2):328-30.
1993: C J Boersma; M A F Sonnemans; Fijs W B van Leeuwen
Immunocytochemical localization of neuropeptide FF (FMRF amide-like peptide) in the hypothalamo-neurohypophyseal system of Wistar and Brattleboro rats by light and electron microscopy.
The Journal of comparative neurology 1993;336(4):555-70.
1993: C J Boersma; Fijs W B van Leeuwen; W G O'Brien; G J Law; W T Mason; R J Bicknell
Dynorphin 1-17 delays the vasopressin induced mobilization of intracellular calcium in cultured astrocytes from the rat neural lobe.
Journal of neuroendocrinology 1993;5(5):583-90.
1993: R J Bicknell; C J Boersma; Fijs W B van Leeuwen; W T Mason
Calcium signaling in neurosecretory terminals and pituicytes.
Annals of the New York Academy of Sciences 1993;689():177-82.
1993: C J Boersma; M A F Sonnemans; Fijs W B van Leeuwen
Immunoelectron microscopic demonstration of oxytocin and vasopressin in pituicytes and in nerve terminals forming synaptoid contacts with pituicytes in the rat neural lobe.
Brain research 1993;611(1):117-29.
1992: B A Th F Gabreëls; M A F Sonnemans; N G Seidah; M Chrétien; Fijs W B van Leeuwen
Dynamics of 7B2 and galanin expression in solitary magnocellular hypothalamic vasopressin neurons of the homozygous Brattleboro rat.
Brain research 1992;585(1-2):275-82.
1992: F J van Eerdenburg; Dick F Swaab; Fijs W B van Leeuwen
Distribution of vasopressin and oxytocin cells and fibres in the hypothalamus of the domestic pig (Sus scrofa).
The Journal of comparative neurology 1992;318(2):138-46.
1992: J F Axelson; W Shannon; Fijs W B van Leeuwen
Immunocytochemical localization of estrogen receptors within neurotensin cells in the rostral preoptic area of the rat hypothalamus.
Neuroscience letters 1992;136(1):5-9.
1992: Fijs W B van Leeuwen
Animal models for osmoregulatory disturbances.
Progress in brain research 1992;93():273-82.
1992: Fijs W B van Leeuwen
Mutant vasopressin precursor producing cells of the homozygous Brattleboro rat as a model for co-expression of neuropeptides.
Progress in brain research 1992;92():149-55.
1991: Fijs W B van Leeuwen; E M vd Beek; Joop J Van Heerikhuize; Arja A Sluiter; Dominik Felix; Hans Imboden
Vasopressin and angiotensin II are absent but spontaneously reappear in solitary hypothalamic neurons of the homozygous Brattleboro rat.
Neuroscience letters 1991;127(2):207-11.
1991: Fijs W B van Leeuwen; E M van der Beek
The amount of mutant vasopressin precursor in the supraoptic and paraventricular nucleus of Brattleboro rats increases with age.
Brain research 1991;542(1):163-6.
1991: G J Ramakers; AB Oestreicher; P S Wolters; Fijs W B van Leeuwen; P N De Graan; Willem Hendrik Gispen
Developmental changes in B-50 (GAP-43) in primary cultures of cerebral cortex: B-50 immunolocalization, axonal elongation rate and growth cone morphology.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1991;9(3):215-30.
1991: A R Caffé; Jan C Holstege; Fijs W B van Leeuwen
Vasopressin immunoreactive fibers and neurons in the dorsal pontine tegmentum of the rat, monkey and human.
Progress in brain research 1991;88():227-40.
1990: F J van Eerdenburg; P Poot; G J Molenaar; Fijs W B van Leeuwen; Dick F Swaab
A vasopressin and oxytocin containing nucleus in the pig hypothalamus that shows neuronal changes during puberty.
The Journal of comparative neurology 1990;301(1):138-46.
1989: A R Caffé; P C Van Ryen; T P Van der Woude; Fijs W B van Leeuwen
Vasopressin and oxytocin systems in the brain and upper spinal cord of Macaca fascicularis.
The Journal of comparative neurology 1989;287(3):302-25.
1989: F G Snijdewint; Fijs W B van Leeuwen; G J Boer
Ontogeny of vasopressin and oxytocin binding sites in the brain of Wistar and Brattleboro rats as demonstrated by lightmicroscopical autoradiography.
Journal of chemical neuroanatomy 1989;2(1):3-17.
1988: A R Caffé; Fijs W B van Leeuwen; Ruud M Buijs; J van der Gugten
Vasopressin and noradrenaline coexistence in the rat locus ceruleus: differential decreases of their levels in distant brain areas after thermal and neurotoxic lesions.
Brain research 1988;459(2):386-90.
1987: Fijs W B van Leeuwen; E M van der Beek; Joop J Van Heerikhuize; P Wolters; G van der Meulen; Y P Wan
Quantitative light microscopic autoradiographic localization of binding sites labelled with [3H]vasopressin antagonist d(CH2)5Tyr(Me)VP in the rat brain, pituitary and kidney.
Neuroscience letters 1987;80(2):121-6.
1987: A R Caffé; Fijs W B van Leeuwen; P G Luiten
Vasopressin cells in the medial amygdala of the rat project to the lateral septum and ventral hippocampus.
The Journal of comparative neurology 1987;261(2):237-52.
1986: Fijs W B van Leeuwen; R Caffé; P J van der Sluis; Arja A Sluiter; T P van der Woude; N G Seidah; M Chrétien
Propressophysin is present in neurones at multiple sites in Wistar and homozygous Brattleboro rat brain.
Brain research 1986;379(1):171-5.
1985: Fijs W B van Leeuwen; Joop J Van Heerikhuize; G van der Meulen; P Wolters
Light microscopic autoradiographic localization of [3H]oxytocin binding sites in the rat brain, pituitary and mammary gland.
Brain research 1985;359(1-2):320-5.
1985: A R Caffé; Fijs W B van Leeuwen; Ruud M Buijs; G J de Vries; M Geffard
Coexistence of vasopressin, neurophysin and noradrenaline immunoreactivity in medium-sized cells of the locus coeruleus and subcoeruleus in the rat.
Brain research 1985;338(1):160-4.
1985: G J DeVries; Ruud M Buijs; Fijs W B van Leeuwen; A R Caffé; Dick F Swaab
The vasopressinergic innervation of the brain in normal and castrated rats.
The Journal of comparative neurology 1985;233(2):236-54.
1985: Fijs W B van Leeuwen; A R Caffe; G J De Vries
Vasopressin cells in the bed nucleus of the stria terminalis of the rat: sex differences and the influence of androgens.
Brain research 1985;325(1-2):391-4.
1984: G J De Vries; Ruud M Buijs; Fijs W B van Leeuwen
Sex differences in vasopressin and other neurotransmitter systems in the brain.
Progress in brain research 1984;61():185-203.
1983: Fijs W B van Leeuwen; P Wolters
Light microscopic autoradiographic localization of [3H]arginine-vasopressin binding sites in the rat brain and kidney.
Neuroscience letters 1983;41(1-2):61-6.
1983: Fijs W B van Leeuwen; G J De Vries
Enkephalin-glial interaction and its consequence for vasopressin and oxytocin release from the rat neural lobe.
Progress in brain research 1983;60():343-51.
1983: Ruud M Buijs; G J De Vries; Fijs W B van Leeuwen; Dick F Swaab
Vasopressin and oxytocin: distribution and putative functions in the brain.
Progress in brain research 1983;60():115-22.
1983: A R Caffé; Fijs W B van Leeuwen
Vasopressin-immunoreactive cells in the dorsomedial hypothalamic region, medial amygdaloid nucleus and locus coeruleus of the rat.
Cell and tissue research 1983;233(1):23-33.
1983: Fijs W B van Leeuwen; Chris W Pool; Arja A Sluiter
Enkephalin immunoreactivity in synaptoid elements on glial cells in the rat neural lobe.
Neuroscience 1983;8(2):229-41.