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René van Lier

Research Profile

Physiology

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Cytomegalovirus Infections

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Olga N Karpus; M Edward Medof; Kris A Reedquist; Jaap D van Buul; René A W van Lier; Ed vanBavel; Corianne C Vandenakker; Henrike Veninga; Dennis Flierman; Robert M Hoek; Jörg Hamann
Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.
Felix M Wensveen; Durdica Cekinovic; Niek de Vries; Ingrid A M Derks; Stipan Jonjic; Paul L Klarenbeek; Maria F Pascutti; Anja ten Brinke; Klaas P J M van Gisbergen; René A W van Lier; Barbera D C van Schaik; Eric Eldering
Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology.
Simone H C Havenith; Ineke J M ten Berge; Karlijn A M I van Donselaar-van der Pant; René A W van Lier; Si-La Yong; Frederike J Bemelman
Everolimus-treated renal transplant recipients have a more robust CMV-specific CD8+ T-cell response compared with cyclosporine- or mycophenolate-treated patients.

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All Publications

2013: Olga N Karpus; M Edward Medof; Kris A Reedquist; Jaap D van Buul; René A W van Lier; Ed vanBavel; Corianne C Vandenakker; Henrike Veninga; Dennis Flierman; Robert M Hoek; Jörg Hamann
Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(7):3740-8.
2013: Felix M Wensveen; Durdica Cekinovic; Niek de Vries; Ingrid A M Derks; Stipan Jonjic; Paul L Klarenbeek; Maria F Pascutti; Anja ten Brinke; Klaas P J M van Gisbergen; René A W van Lier; Barbera D C van Schaik; Eric Eldering
Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(3):1180-91.
2013: Simone H C Havenith; Ineke J M ten Berge; Karlijn A M I van Donselaar-van der Pant; René A W van Lier; Si-La Yong; Frederike J Bemelman
Everolimus-treated renal transplant recipients have a more robust CMV-specific CD8+ T-cell response compared with cyclosporine- or mycophenolate-treated patients.
Transplantation 2013;95(1):184-91.
2012: Simone H C Havenith; Sian M Henson; Mirza M Idu; René E Jonkers; Sven D Koch; Natasja A M Kragten; Berber Piet; René A W van Lier; Si-La Yong; Arne N Akbar; Ineke J M ten Berge
Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells.
International immunology 2012;24(10):625-36.
2012: Kirstin M Heutinck; Jorien Kassies; Ajda T Rowshani; Ineke J M ten Berge; Karlijn A M I van Donselaar-van der Pant; René A W van Lier; Frederike J Bemelman; Nike Claessen; Eric Eldering; Sandrine Florquin; Jörg Hamann
Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cells.
Kidney international 2012;82(6):664-75.
2012: Sanne H Tonino; Pablo J van de Berg; René A W van Lier; Marinus H van Oers; Si-La Yong; Marie José Kersten; Ineke J ten Berge; Arnon P Kater
Expansion of effector T cells associated with decreased PD-1 expression in patients with indolent B cell lymphomas and chronic lymphocytic leukemia.
Leukemia & lymphoma 2012;53(9):1785-94.
2012: Pablo J E J van de Berg; Karlijn A M I van Donselaar-van der Pant; René A W van Lier; Anne van Tellingen; Si-La Yong; Frederike J Bemelman; Sandrine Florquin; Eveline C Hoevenaars; Ineke J M ten Berge
Circulating lymphocyte subsets in different clinical situations after renal transplantation.
Immunology 2012;136(2):198-207.
2012: Pablo J E J van de Berg; René A W van Lier; Si-La Yong; Ester B M Remmerswaal; Ineke J M ten Berge
Cytomegalovirus-induced effector T cells cause endothelial cell damage.
Clinical and vaccine immunology : CVI 2012;19(5):772-9.
2012: Ester B M Remmerswaal; Fréderike J Bemelman; Simone H C Havenith; Mirza M Idu; Anja Ten Brinke; Nelly van der Bom-Baylon; Karlijn A M I van Donselaar; Ester M M van Leeuwen; René A W van Lier; Ineke J M ten Berge
Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes.
Blood 2012;119(7):1702-12.
2012: Felix M Wensveen; HaciAli Yigittop; Alex M de Bruin; Ingrid A M Derks; Eric Eldering; Joost C M Meijers; Martijn A Nolte; Klaas P J M van Gisbergen; René A W van Lier
BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation.
Blood 2012;119(6):1440-9.
2011: Angelic M G van der Aar; René A W van Lier; Rosa de Groot; Esther C de Jong; Marta Sanchez-Hernandez; Esther W M Taanman; Marcel B M Teunissen; Martien L Kapsenberg
Cutting edge: virus selectively primes human langerhans cells for CD70 expression promoting CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3488-92.
2011: Yen-Ming Peng; Ester B M Remmerswaal; Martijn D B van de Garde; René A W van Lier; Paul A Baars; Kai-Fong Cheng; Hsi-Hsien Lin; Charles R Mackay; Jörg Hamann
Specific expression of GPR56 by human cytotoxic lymphocytes.
Journal of leukocyte biology 2011;90(4):735-40.
2011: Berber Piet; Godelieve J De Bree; Barbara S Smids-Dierdorp; Chris M van der Loos; Ester B M Remmerswaal; Jan H von der Thüsen; Jan M W van Haarst; Jan P Eerenberg; Anja ten Brinke; Wim van der Bij; Wim Timens; René A W van Lier; René E Jonkers
CD8⁺ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung.
The Journal of clinical investigation 2011;121(6):2254-63.
2011: Henrike Veninga; Feng-Qi An; Alex M de Bruin; Alex F de Vos; Robert M Hoek; M Edward Medof; Tom van der Poll; René A W van Lier; Jörg Hamann
A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense.
PloS one 2011;6(10):e24431.
2010: Kirsten M L Hertoghs; Perry Moerland; Amber van Stijn; Ester B M Remmerswaal; Si-La Yong; Pablo J E J van de Berg; S Marieke Van Ham; Frank Baas; Ineke J M ten Berge; René A W van Lier
Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation.
The Journal of clinical investigation 2010;120(11):4077-90.
2010: Nacer-Eddine Serriari; Françoise Gondois-Rey; Yves Guillaume; Ester B M Remmerswaal; Sonia Pastor; Nassima Messal; Alemseged Truneh; Ivan Hirsch; René A W van Lier; Daniel Olive
B and T lymphocyte attenuator is highly expressed on CMV-specific T cells during infection and regulates their function.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3140-8.
2010: Paul L Klarenbeek; Paul P Tak; Barbera D C van Schaik; Aeilko H Zwinderman; Marja E Jakobs; Zhuoli Zhang; Antoine H C van Kampen; René A W van Lier; Frank Baas; Niek de Vries
Human T-cell memory consists mainly of unexpanded clones.
Immunology letters 2010;133(1):42-8.
2010: Felix M Wensveen; Klaas P J M van Gisbergen; Ingrid A M Derks; Carmen Gerlach; Ton N Schumacher; René A W van Lier; Eric Eldering
Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones.
Immunity 2010;32(6):754-65.
2010: Pablo J E J van de Berg; Stephen J Griffiths; Si-La Yong; Richard Macaulay; Frederike J Bemelman; Sarah Jackson; Sian M Henson; Ineke J M ten Berge; Arne N Akbar; René A W van Lier
Cytomegalovirus infection reduces telomere length of the circulating T cell pool.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3417-23.
2010: Ronald W van Olffen; Alex M de Bruin; Mariska Vos; Anna D Staniszewska; Jörg Hamann; René A W van Lier; Carlie J M de Vries; Martijn A Nolte
CD70-driven chronic immune activation is protective against atherosclerosis.
Journal of innate immunity 2010;2(4):344-52.
2010: Taco W Kuijpers; Richard Bende; Paul A Baars; Annette Grummels; Ingrid A M Derks; Koert M Dolman; Tim Beaumont; Thomas F Tedder; Carel J M van Noesel; Eric Eldering; René A W van Lier
CD20 deficiency in humans results in impaired T cell-independent antibody responses.
The Journal of clinical investigation 2010;120(1):214-22.
2009: Martijn A Nolte; Ronald W van Olffen; Klaas P J M van Gisbergen; René A W van Lier
Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology.
Immunological reviews 2009;229(1):216-31.
2009: Eleanor Barnes; Huub Gelderblom; Isla Humphreys; Nasser Semmo; Henk W Reesink; Marcel G H M Beld; René A W van Lier; Paul Klenerman
Cellular immune responses during high-dose interferon-alpha induction therapy for hepatitis C virus infection.
The Journal of infectious diseases 2009;199(6):819-28.
2008: Henrike Veninga; Susann Becker; Robert M Hoek; Manja Wobus; Elke Wandel; Jos van der Kaa; Martin van der Valk; Alex F de Vos; Hannelore Haase; Bronwyn Owens; Tom van der Poll; René A W van Lier; Sjef Verbeek; Gabriela Aust; Jörg Hamann
Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6574-83.
2008: Sven D Koch; Elena Uss; René A W van Lier; Ineke J M ten Berge
Alloantigen-induced regulatory CD8+CD103+ T cells.
Human immunology 2008;69(11):737-44.
2008: Nuno L Alves; Ester M M van Leeuwen; Ingrid A M Derks; René A W van Lier
Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5201-10.
2008: Amber van Stijn; Ajda T Rowshani; Si-La Yong; Frank Baas; Eddy Roosnek; Ineke J M ten Berge; René A W van Lier
Human cytomegalovirus infection induces a rapid and sustained change in the expression of NK cell receptors on CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4550-60.
2008: Mireille T M Vossen; Mourad Matmati; Kirsten M L Hertoghs; Paul A Baars; Mi-Ran Gent; Georges Leclercq; Jörg Hamann; Taco W Kuijpers; René A W van Lier
CD27 defines phenotypically and functionally different human NK cell subsets.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):3739-45.
2008: Pablo J E J van de Berg; Amber van Stijn; Ineke J M ten Berge; René A W van Lier
A fingerprint left by cytomegalovirus infection in the human T cell compartment.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2008;41(3):213-7.
2008: N Nikolaeva; Frederike J Bemelman; Si-La Yong; A Verschuur; René A W van Lier; Ineke J M ten Berge
The pyrimidin analogue cyclopentenyl cytosine induces alloantigen-specific non-responsiveness of human T lymphocytes.
Clinical and experimental immunology 2008;151(2):348-58.
2007: G Johan A Offerhaus; M E I Schipper; Audrey J Lazenby; Elizabeth Montgomery; Folkert H M Morsink; Richard Bende; Alex R Musler; René A W van Lier; Carel J M van Noesel
Graft-versus-host-like disease complicating thymoma: lack of AIRE expression as a cause of non-hereditary autoimmunity?
Immunology letters 2007;114(1):31-7.
2007: Nuno L Alves; Ester M M van Leeuwen; Ester B M Remmerswaal; Nienke Vrisekoop; kiki tesselaar; Eddy Roosnek; Ineke J M ten Berge; René A W van Lier
A new subset of human naive CD8+ T cells defined by low expression of IL-7R alpha.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):221-8.
2007: Michiel F van Oosterwijk; Hedi Juwana; Ramon Arens; kiki tesselaar; Marinus H J van Oers; Eric Eldering; René A W van Lier
CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development.
International immunology 2007;19(6):713-8.
2007: Godelieve J De Bree; Hans Daniels; Muriel van Schilfgaarde; Henk M Jansen; Theo A Out; René A W van Lier; René E Jonkers
Characterization of CD4+ memory T cell responses directed against common respiratory pathogens in peripheral blood and lung.
The Journal of infectious diseases 2007;195(11):1718-25.
2007: Elena Uss; Si-La Yong; Berend Hooibrink; René A W van Lier; Ineke J M ten Berge
Rapamycin enhances the number of alloantigen-induced human CD103+CD8+ regulatory T cells in vitro.
Transplantation 2007;83(8):1098-106.
2007: Nuno L Alves; Fernando A. Arosa; René A W van Lier
Common gamma chain cytokines: dissidence in the details.
Immunology letters 2007;108(2):113-20.
2007: Amale Laouar; Monika Manocha; Meimei Wan; Hideo Yagita; René A W van Lier; N Manjunath
Cutting Edge: Distinct NK receptor profiles are imprinted on CD8 T cells in the mucosa and periphery during the same antigen challenge: role of tissue-specific factors.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):652-6.
2007: Ester M M van Leeuwen; Ineke J M ten Berge; René A W van Lier
Induction and maintenance of CD8+ T cells specific for persistent viruses.
Advances in experimental medicine and biology 2007;590():121-37.
2007: Nuno L Alves; René A W van Lier; Eric Eldering
Withdrawal symptoms on display: Bcl-2 members under investigation.
Trends in immunology 2007;28(1):26-32.
2006: Catharina W Wieland; Marjolein E Kerver; Sandrine Florquin; Martijn A Nolte; Jannie Borst; René A W van Lier; Marinus H J van Oers; Tom van der Poll
CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome.
International immunology 2006;18(11):1531-9.
2006: Ester M M van Leeuwen; Ester B M Remmerswaal; Mirjam H M Heemskerk; Ineke J M ten Berge; René A W van Lier
Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection.
Blood 2006;108(9):3121-7.
2006: Martijn A Nolte; René A W van Lier
The price of the CD27-CD70 costimulatory axis: you can't have it all.
The Journal of experimental medicine 2006;203(11):2405-8.
2006: Ester M M van Leeuwen; Jasper J Koning; Ester B M Remmerswaal; Debbie Van Baarle; René A W van Lier; Ineke J M ten Berge
Differential usage of cellular niches by cytomegalovirus versus EBV- and influenza virus-specific CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):4998-5005.
2006: René A W van Lier; René Lutter
The bug in MyD88 dependency.
Immunity 2006;25(4):527-9.
2006: Elena Uss; Ajda T Rowshani; Berend Hooibrink; Neubury M Lardy; René A W van Lier; Ineke J M ten Berge
CD103 is a marker for alloantigen-induced regulatory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):2775-83.
2006: Ester M M van Leeuwen; Godelieve J De Bree; Ineke J M ten Berge; René A W van Lier
Human virus-specific CD8+ T cells: diversity specialists.
Immunological reviews 2006;211():225-35.
2006: Nuno L Alves; Ingrid A M Derks; Erik Berk; rene spijker; René A W van Lier; Eric Eldering
The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells.
Immunity 2006;24(6):703-16.
2006: R Mous; P Savage; Ester B M Remmerswaal; René A W van Lier; Eric Eldering; Marinus H J van Oers
Redirection of CMV-specific CTL towards B-CLL via CD20-targeted HLA/CMV complexes.
Leukemia 2006;20(6):1096-102.
2006: Natalia Nikolaeva; Frederike J Bemelman; Si-La Yong; René A W van Lier; Ineke J M ten Berge
Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cells.
Transplantation 2006;81(3):445-54.
2006: Wendy S Bril; Pauline M W van Helden; Christina Hausl; Marleen G Zuurveld; Rafi U Ahmad; Martine J Hollestelle; Pieter H Reitsma; Karin Fijnvandraat; René A W van Lier; Hans Peter Schwarz; Koen Mertens; Birgit M Reipert; Jan Voorberg
Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg(593) to Cys substitution.
Thrombosis and haemostasis 2006;95(2):341-7.
2006: Hendrik P J Bonarius; Frank Baas; Ester B M Remmerswaal; René A W van Lier; Ineke J M ten Berge; Paul P Tak; Niek de Vries
Monitoring the T-cell receptor repertoire at single-clone resolution.
PloS one 2006;1():e55.
2006: Else N Kop; Janik Adriaansen; Tom J M Smeets; Margriet J Vervoordeldonk; René A W van Lier; Jörg Hamann; Paul P Tak
CD97 neutralisation increases resistance to collagen-induced arthritis in mice.
Arthritis research & therapy 2006;8(5):R155.
2006: Yves Chalandon; Sylvie Degermann; Jean Villard; Lionel Arlettaz; Laurent Kaiser; Solange Vischer; Steffen Walter; Mirjam H M Heemskerk; René A W van Lier; Claudine Helg; Bernard Chapuis; Eddy Roosnek
Pretransplantation CMV-specific T cells protect recipients of T-cell-depleted grafts against CMV-related complications.
Blood 2006;107(1):389-96.
2005: Godelieve J De Bree; Ester M M van Leeuwen; Theo A Out; Henk M Jansen; René E Jonkers; René A W van Lier
Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung.
The Journal of experimental medicine 2005;202(10):1433-42.
2005: Mireille T M Vossen; Mi-Ran Gent; Karla M C Peters; Pauline M E Wertheim-van Dillen; Koert M Dolman; Alex Van Breda; René A W van Lier; Taco W Kuijpers
Persistent detection of varicella-zoster virus DNA in a previously healthy child after severe chickenpox.
Journal of clinical microbiology 2005;43(11):5614-21.
2005: Paul A Baars; Sophie Sierro; Ramon Arens; kiki tesselaar; Berend Hooibrink; Paul Klenerman; René A W van Lier
Properties of murine (CD8+)CD27- T cells.
European journal of immunology 2005;35(11):3131-41.
2005: Ester M M van Leeuwen; Godelieve J De Bree; Ester B M Remmerswaal; Si-La Yong; kiki tesselaar; Ineke J M ten Berge; René A W van Lier
IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells.
Blood 2005;106(6):2091-8.
2005: Nuno L Alves; Fernando A. Arosa; René A W van Lier
IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):755-62.
2005: Amale Laouar; Viraga Haridas; Dorothy Vargas; Xia Zhinan; David Chaplin; René A W van Lier; N Manjunath
CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa.
Nature immunology 2005;6(7):698-706.
2005: Ester M M van Leeuwen; Jaap D van Buul; Ester B M Remmerswaal; Peter L Hordijk; Ineke J M ten Berge; René A W van Lier
Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation.
International immunology 2005;17(6):713-9.
2005: Ramon Arens; Paul A Baars; Margot Jak; kiki tesselaar; Martin van der Valk; Marinus H J van Oers; René A W van Lier
Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):5915-20.
2005: Godelieve J De Bree; Jojanneke Heidema; Ester M M van Leeuwen; Grada M van Bleek; René E Jonkers; Henk M Jansen; René A W van Lier; Theo A Out
Respiratory syncytial virus-specific CD8+ memory T cell responses in elderly persons.
The Journal of infectious diseases 2005;191(10):1710-8.
2005: Martijn A Nolte; Ramon Arens; Ronald van Os; Michiel F van Oosterwijk; Berend Hooibrink; René A W van Lier; Marinus H J van Oers
Immune activation modulates hematopoiesis through interactions between CD27 and CD70.
Nature immunology 2005;6(4):412-8.
2005: Wendelina J M Mackus; Arnon P Kater; Annette Grummels; Ludo M Evers; B Hooijbrink; Mark H H Kramer; Januario E Castro; Thomas Kipps; René A W van Lier; Marinus H J van Oers; Eric Eldering
Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation.
Leukemia 2005;19(3):427-34.
2005: Ajda T Rowshani; Frederike J Bemelman; Ester M M van Leeuwen; René A W van Lier; Ineke J M ten Berge
Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients.
Transplantation 2005;79(4):381-6.
2005: Mireille T M Vossen; Maarten H Biezeveld; Menno D De Jong; Mi-Ran Gent; Paul A Baars; Ines A Von Rosenstiel; René A W van Lier; Taco W Kuijpers
Absence of circulating natural killer and primed CD8+ cells in life-threatening varicella.
The Journal of infectious diseases 2005;191(2):198-206.
2005: M Judith Eikelenboom; Joep Killestein; Thijs Izeboud; Nynke F Kalkers; Paul A Baars; René A W van Lier; Frederik Barkhof; Bernard Uitdehaag; Chris H Polman
Expression of adhesion molecules on peripheral lymphocytes predicts future lesion development in MS.
Journal of neuroimmunology 2005;158(1-2):222-30.
2005: Mark J Kwakkenbos; Walter Pouwels; Mourad Matmati; Martin Stacey; Hsi-Hsien Lin; Siamon Gordon; René A W van Lier; Jörg Hamann
Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells.
Journal of leukocyte biology 2005;77(1):112-9.
2004: Arnon P Kater; Ludo M Evers; Ester B M Remmerswaal; Annelieke Jaspers; Michiel F Oosterwijk; René A W van Lier; Marinus H J van Oers; Eric Eldering
CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack.
British journal of haematology 2004;127(4):404-15.
2004: Natalia Nikolaeva; Elena Uss; Ester M M van Leeuwen; René A W van Lier; Ineke J M ten Berge
Differentiation of human alloreactive CD4+ and CD8+ T cells in vitro.
Transplantation 2004;78(6):815-24.
2004: Ramon Arens; Martijn A Nolte; kiki tesselaar; Bianca Heemskerk; Kris A Reedquist; René A W van Lier; Marinus H J van Oers
Signaling through CD70 regulates B cell activation and IgG production.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3901-8.
2004: A H M Bouts; Jean-Claude Davin; R T Krediet; Leo A H Monnens; Jeroen Nauta; C H Schröder; René A W van Lier; Theo A Out
Children with chronic renal failure have reduced numbers of memory B cells.
Clinical and experimental immunology 2004;137(3):589-94.
2004: Arnon P Kater; Ester B M Remmerswaal; Martijn A Nolte; Eric Eldering; Marinus H J van Oers; René A W van Lier
Autologous cytomegalovirus-specific T cells as effector cells in immunotherapy of B cell chronic lymphocytic leukaemia.
British journal of haematology 2004;126(4):512-6.
2004: Ester M M van Leeuwen; Ester B M Remmerswaal; Mireille T M Vossen; Ajda T Rowshani; Pauline M E Wertheim-van Dillen; René A W van Lier; Ineke J M ten Berge
Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1834-41.
2004: Eric Eldering; Wendelina J M Mackus; Ingrid A M Derks; Ludo M Evers; Esther Beuling; Peter Teeling; Susanne M A Lens; Marinus H J van Oers; René A W van Lier
Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome C release, and caspase-9 activation.
European journal of immunology 2004;34(7):1950-60.
2004: Mireille T M Vossen; Mi-Ran Gent; Jan F L Weel; Menno D De Jong; René A W van Lier; Taco W Kuijpers
Development of virus-specific CD4+ T cells on reexposure to Varicella-Zoster virus.
The Journal of infectious diseases 2004;190(1):72-82.
2004: Laila E Gamadia; Ester B M Remmerswaal; Sugianto Surachno; Neubury M Lardy; Pauline M E Wertheim-van Dillen; René A W van Lier; Ineke J M ten Berge
Cross-reactivity of cytomegalovirus-specific CD8+ T cells to allo-major histocompatibility complex class I molecules.
Transplantation 2004;77(12):1879-85.
2004: Ramon Arens; Koen Schepers; Martijn A Nolte; Michiel F van Oosterwijk; René A W van Lier; Schumacher Ton; Marinus H J van Oers
Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formation.
The Journal of experimental medicine 2004;199(11):1595-605.
2004: Laila E Gamadia; Ester M M van Leeuwen; Ester B M Remmerswaal; Si-La Yong; Sugianto Surachno; Pauline M E Wertheim-van Dillen; Ineke J M ten Berge; René A W van Lier
The size and phenotype of virus-specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6107-14.
2004: Laila E Gamadia; Rob J Rentenaar; René A W van Lier; Ineke J M ten Berge
Properties of CD4(+) T cells in human cytomegalovirus infection.
Human immunology 2004;65(5):486-92.
2004: Martijn A Nolte; Ramon Arens; Manfred Kraus; Marinus H J van Oers; Georg Kraal; René A W van Lier; Reina E Mebius
B cells are crucial for both development and maintenance of the splenic marginal zone.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3620-7.
2004: Ajda T Rowshani; Alena Uss; Si-La Yong; René A W van Lier; Ineke J M ten Berge
Effects of CD25 monoclonal antibody on proliferative and effector functions of alloactivated human T cells in vitro.
European journal of immunology 2004;34(3):882-99.
2004: Mireille T M Vossen; Mi-Ran Gent; Jean-Claude Davin; Paul A Baars; Pauline M E Wertheim-van Dillen; Jan F L Weel; Marijke Th L Roos; Debbie Van Baarle; Jaap W Groothoff; René A W van Lier; Taco W Kuijpers
Spontaneous outgrowth of EBV-transformed B-cells reflects EBV-specific immunity in vivo; a useful tool in the follow-up of EBV-driven immunoproliferative disorders in allograft recipients.
Transplant international : official journal of the European Society for Organ Transplantation 2004;17(2):89-96.
2004: Jaklien C Leemans; Anje A Te Velde; Sandrine Florquin; Roelof J Bennink; Kora de Bruin; René A W van Lier; Tom van der Poll; Jörg Hamann
The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):1125-31.
2003: René A W van Lier; Ineke J M ten Berge; Laila E Gamadia
Human CD8(+) T-cell differentiation in response to viruses.
Nature reviews. Immunology 2003;3(12):931-9.
2003: Nuno L Alves; Berend Hooibrink; Fernando A. Arosa; René A W van Lier
IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro.
Blood 2003;102(7):2541-6.
2003: Joep Killestein; M Judith Eikelenboom; Thijs Izeboud; Nynke F Kalkers; Herman J Adèr; Frederik Barkhof; René A W van Lier; Bernard Uitdehaag; Chris H Polman
Cytokine producing CD8+ T cells are correlated to MRI features of tissue destruction in MS.
Journal of neuroimmunology 2003;142(1-2):141-8.
2003: Wendelina J M Mackus; Florine N J Frakking; Annette Grummels; Laila E Gamadia; Godelieve J De Bree; Dörte Hamann; René A W van Lier; Marinus H J van Oers
Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia.
Blood 2003;102(3):1057-63.
2003: Heleen C Heystek; Bianca den Drijver; Martien L Kapsenberg; René A W van Lier; Esther C de Jong
Type I IFNs differentially modulate IL-12p70 production by human dendritic cells depending on the maturation status of the cells and counteract IFN-gamma-mediated signaling.
Clinical immunology (Orlando, Fla.) 2003;107(3):170-7.
2003: Jörg Hamann; Mark J Kwakkenbos; Esther C de Jong; Henk Heus; Anne S Olsen; René A W van Lier
Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence.
European journal of immunology 2003;33(5):1365-71.
2003: Taco W Kuijpers; Mireille T M Vossen; Mi-Ran Gent; Jean-Claude Davin; Marijke Th L Roos; Pauline M E Wertheim-van Dillen; Jan F L Weel; Paul A Baars; René A W van Lier
Frequencies of circulating cytolytic, CD45RA+CD27-, CD8+ T lymphocytes depend on infection with CMV.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4342-8.
2003: Laila E Gamadia; Ester B M Remmerswaal; Jan F L Weel; Frederike J Bemelman; René A W van Lier; Ineke J M ten Berge
Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease.
Blood 2003;101(7):2686-92.
2003: kiki tesselaar; Yanling Xiao; Ramon Arens; Gijs M W van Schijndel; Danita Schuurhuis; Reina E Mebius; Jannie Borst; René A W van Lier
Expression of the murine CD27 ligand CD70 in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):33-40.
2003: kiki tesselaar; Ramon Arens; Gijs M W van Schijndel; Paul A Baars; Martin A van der Valk; Jannie Borst; Marinus H J van Oers; René A W van Lier
Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions.
Nature immunology 2003;4(1):49-54.
2002: M Judith Eikelenboom; Joep Killestein; Thijs Izeboud; Nynke F Kalkers; René A W van Lier; Frederik Barkhof; Bernard Uitdehaag; Chris H Polman
Chemokine receptor expression on T cells is related to new lesion development in multiple sclerosis.
Journal of neuroimmunology 2002;133(1-2):225-32.
2002: Joep Killestein; Rogier Q Hintzen; Bernard Uitdehaag; Paul A Baars; Marijke Th L Roos; René A W van Lier; Chris H Polman
Baseline T cell reactivity in multiple sclerosis is correlated to efficacy of interferon-beta.
Journal of neuroimmunology 2002;133(1-2):217-24.
2002: Ester M M van Leeuwen; Laila E Gamadia; Paul A Baars; Ester B M Remmerswaal; Ineke J M ten Berge; René A W van Lier
Proliferation requirements of cytomegalovirus-specific, effector-type human CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5838-43.
2002: Lizette Visser; Alex F de Vos; Jörg Hamann; Marie-José Melief; Marjan van Meurs; René A W van Lier; Jon D Laman; Rogier Q Hintzen
Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis.
Journal of neuroimmunology 2002;132(1-2):156-63.
2002: Lizet E van der Kolk; Ludo M Evers; CO Omene; Susanne M A Lens; S Lederman; René A W van Lier; Marinus H J van Oers; Eric Eldering
CD20-induced B cell death can bypass mitochondria and caspase activation.
Leukemia 2002;16(9):1735-44.
2002: Rob J Rentenaar; Frank N J van Diepen; René T Meijer; Sugianto Surachno; Joep M Wilmink; P T A Schellekens; Steven T Pals; René A W van Lier; Ineke J M ten Berge
Immune responsiveness in renal transplant recipients: mycophenolic acid severely depresses humoral immunity in vivo.
Kidney international 2002;62(1):319-28.
2002: Mark J Kwakkenbos; Gin-Wen Chang; Hsi-Hsien Lin; Walter Pouwels; Esther C de Jong; René A W van Lier; Siamon Gordon; Jörg Hamann
The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells.
Journal of leukocyte biology 2002;71(5):854-62.
2002: Joep Killestein; Martijn Rep; Jan F Meilof; Herman J Adèr; Bernard Uitdehaag; Frederik Barkhof; René A W van Lier; Chris H Polman
Seasonal variation in immune measurements and MRI markers of disease activity in MS.
Neurology 2002;58(7):1077-80.
2002: Rob J Rentenaar; Jelle L G Vosters; Frank N J van Diepen; Ester B M Remmerswaal; René A W van Lier; Ineke J M ten Berge
Differentiation of human alloreactive CD8(+) T cells in vitro.
Immunology 2002;105(3):278-85.
2002: Laila E Gamadia; Ineke J M ten Berge; Louis J Picker; René A W van Lier
Skewed maturation of virus-specific CTLs?
Nature immunology 2002;3(3):203.
2001: Ineke J M ten Berge; Laila E Gamadia; Ester B M Remmerswaal; Sugianto Surachno; Jan F L Weel; Mireille Toebes; Schumacher Ton; René A W van Lier
Differentiation of CMV-specific CD8(POS) T lymphocytes in primary CMV infection after renal transplantation.
Transplantation proceedings 2001;33(7-8):3630.
2001: Ramon Arens; kiki tesselaar; Paul A Baars; Gijs M W van Schijndel; Jenny Hendriks; Steven T Pals; Paul Krimpenfort; Jannie Borst; Marinus H J van Oers; René A W van Lier
Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion.
Immunity 2001;15(5):801-12.
2001: Joep Killestein; Nynke F Kalkers; Jan F Meilof; Frederik Barkhof; René A W van Lier; Chris H Polman
TNFalpha production by CD4(+) T cells predicts long-term increase in lesion load on MRI in MS.
Neurology 2001;57(6):1129-31.
2001: Rob J Rentenaar; Jesse de Metz; M Bunders; Pauline M E Wertheim-van Dillen; Dirk J Gouma; Johannes A Romijn; Hans P Sauerwein; Ineke J M ten Berge; René A W van Lier
Interferon-gamma administration after abdominal surgery rescues antigen-specific helper T cell immune reactivity.
Clinical and experimental immunology 2001;125(3):401-8.
2001: Joep Killestein; Martijn Rep; Frederik Barkhof; Marijke Th L Roos; Herman J Adèr; René A W van Lier; Chris H Polman
Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells.
Journal of neuroimmunology 2001;118(2):286-94.
2001: Laila E Gamadia; Rob J Rentenaar; Paul A Baars; Ester B M Remmerswaal; Sugianto Surachno; Jan F L Weel; Mireille Toebes; Schumacher Ton; Ineke J M ten Berge; René A W van Lier
Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers.
Blood 2001;98(3):754-61.
2001: Joep Killestein; B F Den Drijver; W L Van der Graaff; Bernard Uitdehaag; Chris H Polman; René A W van Lier
Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease.
Multiple sclerosis (Houndmills, Basingstoke, England) 2001;7(3):145-50.
2001: Rob J Rentenaar; Laila E Gamadia; N van der Hoek; Frank N J van Diepen; Rene Boom; Jan F L Weel; René A W van Lier; Ineke J M ten Berge
CD4(+) T-cell dynamics in primary cytomegalovirus infection.
Transplantation proceedings 2001;33(3):2313-4.
2001: Lies H Jaspars; Wim Vos; G Aust; René A W van Lier; Jörg Hamann
Tissue distribution of the human CD97 EGF-TM7 receptor.
Tissue antigens 2001;57(4):325-31.
2001: René T Meijer; Si-La Yong; Ineke J M ten Berge; René A W van Lier; P T A Schellekens
Non FcR-binding murine antihuman CD3 monoclonal antibody is capable of productive TCR signalling and induces proliferation in the presence of costimulation.
Clinical and experimental immunology 2001;123(3):511-9.
2001: Rob J Rentenaar; Laila E Gamadia; N van der Hoek; Frank N J van Diepen; Pauline M E Wertheim-van Dillen; Jan F L Weel; Sugianto Surachno; René A W van Lier; Ineke J M ten Berge
CD8(POS) lymphocyte dynamics in primary CMV infection.
Transplantation proceedings 2001;33(1-2):1867-9.
2001: Laila E Gamadia; Rob J Rentenaar; Ester B M Remmerswaal; Sugianto Surachno; Jan F L Weel; Mireille Toebes; Schumacher Ton; René A W van Lier; Ineke J M ten Berge
CMV-specific CD8(pos) T lymphocyte differentiation in latent CMV infection.
Transplantation proceedings 2001;33(1-2):1802-3.
2001: Rob J Rentenaar; J L Vosters; René A W van Lier; Ineke J M ten Berge
Detection of allospecific T cells by intracellular cytokine staining and flowcytometry.
Transplantation proceedings 2001;33(1-2):426-7.
2000: Jenny Hendriks; LA Gravestein; kiki tesselaar; René A W van Lier; Schumacher Ton; Jannie Borst
CD27 is required for generation and long-term maintenance of T cell immunity.
Nature immunology 2000;1(5):433-40.
2000: Paul A Baars; Laura M Ribeiro-do-Couto; Jeanette Leusen; Berend Hooibrink; Taco W Kuijpers; SM Lens; René A W van Lier
Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8+CD45RA+CD27- human T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1910-7.
2000: Marijke Th L Roos; René A W van Lier; Dörte Hamann; Gerlinde J Knol; I Verhoofstad; Debbie Van Baarle; Frank Miedema; P T A Schellekens
Changes in the composition of circulating CD8+ T cell subsets during acute epstein-barr and human immunodeficiency virus infections in humans.
The Journal of infectious diseases 2000;182(2):451-8.
2000: Jörg Hamann; C van Zeventer; A Bijl; C Molenaar; kiki tesselaar; René A W van Lier
Molecular cloning and characterization of mouse CD97.
International immunology 2000;12(4):439-48.
2000: Rob J Rentenaar; Laila E Gamadia; N van DerHoek; Frank N J van Diepen; Rene Boom; Jan F L Weel; Pauline M E Wertheim-van Dillen; René A W van Lier; Ineke J M ten Berge
Development of virus-specific CD4(+) T cells during primary cytomegalovirus infection.
The Journal of clinical investigation 2000;105(4):541-8.
1999: René A W van Lier; Paul A Baars
Assessing the replicative history of human T cells.
Mutation research 1999;431(2):177-80.
1999: Taco W Kuijpers; A Wiegman; René A W van Lier; Marijke Th L Roos; Pauline M E Wertheim-van Dillen; S Pinedo; Jaap Ottenkamp
Kawasaki disease: a maturational defect in immune responsiveness.
The Journal of infectious diseases 1999;180(6):1869-77.
1999: SM Lens; Paul Drillenburg; Bianca den Drijver; Gijs M W van Schijndel; Steven T Pals; René A W van Lier; Marinus H J van Oers
Aberrant expression and reverse signalling of CD70 on malignant B cells.
British journal of haematology 1999;106(2):491-503.
1999: Dörte Hamann; Stefan Kostense; Katja C Wolthers; Sigrid A Otto; Paul A Baars; Frank Miedema; René A W van Lier
Evidence that human CD8+CD45RA+CD27- cells are induced by antigen and evolve through extensive rounds of division.
International immunology 1999;11(7):1027-33.
1999: Martijn Rep; H M Schrijver; T van Lopik; Rogier Q Hintzen; Marijke Th L Roos; Herman J Adèr; Chris H Polman; René A W van Lier
Interferon (IFN)-beta treatment enhances CD95 and interleukin 10 expression but reduces interferon-gamma producing T cells in MS patients.
Journal of neuroimmunology 1999;96(1):92-100.
1999: Jörg Hamann; J O Wishaupt; René A W van Lier; Tom J M Smeets; Ferdinand C Breedveld; Paul P Tak
Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue.
Arthritis and rheumatism 1999;42(4):650-8.
1999: Dörte Hamann; Marijke Th L Roos; René A W van Lier
Faces and phases of human CD8 T-cell development.
Immunology today 1999;20(4):177-80.
1998: SM Lens; kiki tesselaar; Marinus H J van Oers; René A W van Lier
Control of lymphocyte function through CD27-CD70 interactions.
Seminars in immunology 1998;10(6):491-9.
1998: SM Lens; Bianca den Drijver; A J Pötgens; kiki tesselaar; Marinus H J van Oers; René A W van Lier
Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):6083-92.
1998: Jörg Hamann; Catelijne Stortelers; E Kiss-Toth; Björn Vogel; Wolfram Eichler; René A W van Lier
Characterization of the CD55 (DAF)-binding site on the seven-span transmembrane receptor CD97.
European journal of immunology 1998;28(5):1701-7.
1997: kiki tesselaar; LA Gravestein; Gijs M W van Schijndel; Jannie Borst; René A W van Lier
Characterization of murine CD70, the ligand of the TNF receptor family member CD27.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4959-65.
1997: Dörte Hamann; Paul A Baars; Martijn Rep; Berend Hooibrink; SR Kerkhof-Garde; Michel Klein; René A W van Lier
Phenotypic and functional separation of memory and effector human CD8+ T cells.
The Journal of experimental medicine 1997;186(9):1407-18.
1997: Taco W Kuijpers; René A W van Lier; Dörte Hamann; Martin de Boer; L Y Thung; Ron S Weening; Arthur J Verhoeven; Mustafa Yavuz Köker
Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins.
The Journal of clinical investigation 1997;100(7):1725-33.
1997: Katja C Wolthers; Sigrid A Otto; SM Lens; René A W van Lier; Frank Miedema; L Meyaard
Functional B cell abnormalities in HIV type 1 infection: role of CD40L and CD70.
AIDS research and human retroviruses 1997;13(12):1023-9.
1997: Martijn Rep; Bob W van Oosten; Marijke Th L Roos; Herman J Adèr; Chris H Polman; René A W van Lier
Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-gamma secreting TH1 cells in humans.
The Journal of clinical investigation 1997;99(9):2225-31.
1997: SM Lens; Paul A Baars; Berend Hooibrink; Marinus H J van Oers; René A W van Lier
Antigen-presenting cell-derived signals determine expression levels of CD70 on primed T cells.
Immunology 1997;90(1):38-45.
1997: Jörg Hamann; K T Montgomery; S Lau; R Kucherlapati; René A W van Lier
AICL: a new activation-induced antigen encoded by the human NK gene complex.
Immunogenetics 1997;45(5):295-300.
1996: René A W van Lier; Wolfram Eichler; Jörg Hamann
Sevenspan transmembrane molecules: novel receptors involved in leukocyte adhesion.
Immunology letters 1996;54(2-3):185-7.
1996: A C Lankester; G M Schijndel; Nadine Pakker; R H Van Oers; René A W van Lier
Antigen receptor function in chronic lymphocytic leukemia B cells.
Leukemia & lymphoma 1996;24(1-2):27-33.
1996: SM Lens; R de Jong; Berend Hooibrink; Gerrit Koopman; Steven T Pals; Marinus H J van Oers; René A W van Lier
Phenotype and function of human B cells expressing CD70 (CD27 ligand).
European journal of immunology 1996;26(12):2964-71.
1996: A C Lankester; P M Rood; G M van Schijndel; Berend Hooibrink; Arthur J Verhoeven; René A W van Lier
Alteration of B-cell antigen receptor signaling by CD19 co-ligation. A study with bispecific antibodies.
The Journal of biological chemistry 1996;271(37):22326-30.
1996: Jörg Hamann; B Vogel; G M van Schijndel; René A W van Lier
The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF).
The Journal of experimental medicine 1996;184(3):1185-9.
1996: Menno A de Rie; I M Zonneveld; leonard witkamp; René A W van Lier; Theo A Out; Jan D Bos
Soluble interleukin-2 receptor (sIL-2R) is a marker of disease activity in psoriasis: a comparison of sIL-2R, sCD27, sCD4, sCD8 and sICAM-1.
Acta dermato-venereologica 1996;76(5):357-60.
1996: Katja C Wolthers; Sigrid A Otto; SM Lens; D N Kolbach; René A W van Lier; Frank Miedema; L Meyaard
Increased expression of CD80, CD86 and CD70 on T cells from HIV-infected individuals upon activation in vitro: regulation by CD4+ T cells.
European journal of immunology 1996;26(8):1700-6.
1996: Paul P Tak; R Q Hintzen; J J Teunissen; Tom J M Smeets; Mohamed R Daha; René A W van Lier; P M Kluin; A E Meinders; A J Swaak; Ferdinand C Breedveld
Expression of the activation antigen CD27 in rheumatoid arthritis.
Clinical immunology and immunopathology 1996;80(2):129-38.
1996: Martijn Rep; R Q Hintzen; Chris H Polman; René A W van Lier
Recombinant interferon-beta blocks proliferation but enhances interleukin-10 secretion by activated human T-cells.
Journal of neuroimmunology 1996;67(2):111-8.
1996: A C Lankester; René A W van Lier
Compartmentalization of B-cell antigen receptor functions.
Molecular immunology 1996;33(9):769-75.
1996: Bob W van Oosten; Martijn Rep; René A W van Lier; P E Scholten; B M von Blomberg; K W Pflughaupt; H P Hartung; H J Adèr; Chris H Polman
A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis.
Journal of neuroimmunology 1996;66(1-2):49-55.
1996: SM Lens; Robert M J Keehnen; Marinus H J van Oers; René A W van Lier; Steven T Pals; Gerrit Koopman
Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70.
European journal of immunology 1996;26(5):1007-11.
1996: Menno A de Rie; I Cairo; René A W van Lier; Jan D Bos
Expression of the T-cell activation antigens CD27 and CD28 in normal and psoriatic skin.
Clinical and experimental dermatology 1996;21(2):104-11.
1996: Marie José Kersten; Ludo M Evers; P L Dellemijn; H van den Berg; Peter Portegies; R Q Hintzen; René A W van Lier; Albert E G Kr von dem Borne; R H van Oers
Elevation of cerebrospinal fluid soluble CD27 levels in patients with meningeal localization of lymphoid malignancies.
Blood 1996;87(5):1985-9.
1996: Jörg Hamann; E Hartmann; René A W van Lier
Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily.
Genomics 1996;32(1):144-7.
1996: Dörte Hamann; Catharien M U Hilkens; Jane Grogan; SM Lens; Martien L Kapsenberg; Maria Yazdanbakhsh; René A W van Lier
CD30 expression does not discriminate between human Th1- and Th2-type T cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(4):1387-91.
1996: Dörte Hamann; Wolfram Eichler; H Fiebig; René A W van Lier
Conformational changes in CD45 upon monoclonal antibody crosslinking.
Hybridoma 1996;15(1):11-6.
1996: SM Lens; kiki tesselaar; B F den Drijver; Marinus H J van Oers; René A W van Lier
A dual role for both CD40-ligand and TNF-alpha in controlling human B cell death.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):507-14.
1995: A C Lankester; G M van Schijndel; René A W van Lier
Hematopoietic cell phosphatase is recruited to CD22 following B cell antigen receptor ligation.
The Journal of biological chemistry 1995;270(35):20305-8.
1995: Jörg Hamann; Wolfram Eichler; Dörte Hamann; H M Kerstens; P J Poddighe; J M Hoovers; E Hartmann; M Strauss; René A W van Lier
Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1942-50.
1995: H M Kuiper; Mieke C Brouwer; Peter Linsley; René A W van Lier
Activated T cells can induce high levels of CTLA-4 expression on B cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1776-83.
1995: A C Lankester; G M van Schijndel; C. Ellen van der Schoot; M H van Oers; Carel J M van Noesel; René A W van Lier
Antigen receptor nonresponsiveness in chronic lymphocytic leukemia B cells.
Blood 1995;86(3):1090-7.
1995: SM Lens; R de Jong; R Q Hintzen; Gerrit Koopman; René A W van Lier; R H van Oers
CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth.
Leukemia & lymphoma 1995;18(1-2):51-9.
1995: P Kaliński; Catharien M U Hilkens; Eddy A Wierenga; Tineke C T M van der Pouw Kraan; René A W van Lier; Jan D Bos; Martien L Kapsenberg; F G Snijdewint
Functional maturation of human naive T helper cells in the absence of accessory cells. Generation of IL-4-producing T helper cells does not require exogenous IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):3753-60.
1995: R Q Hintzen; SM Lens; Karen Lammers; H Kuiper; M P Beckmann; René A W van Lier
Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(6):2612-23.
1995: H M Kuiper; SM Lens; R Q Hintzen; René A W van Lier
Lymphocyte costimulation: multiple pathways, multiple functions?
Research in immunology 1995;146(3):180-3.
1995: Paul A Baars; M M Maurice; Martijn Rep; Berend Hooibrink; René A W van Lier
Heterogeneity of the circulating human CD4+ T cell population. Further evidence that the CD4+CD45RA-CD27- T cell subset contains specialized primed T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(1):17-25.
1995: R Q Hintzen; Urszula Fiszer; Sten Fredrikson; Martijn Rep; Chris H Polman; René A W van Lier; H Link
Analysis of CD27 surface expression on T cell subsets in MS patients and control individuals.
Journal of neuroimmunology 1995;56(1):99-105.
1995: L Meyaard; H Kuiper; Sigrid A Otto; Katja C Wolthers; René A W van Lier; Frank Miedema
Evidence for intact costimulation via CD28 and CD27 molecules in hyporesponsive T cells from human immunodeficiency virus-infected individuals.
European journal of immunology 1995;25(1):232-7.
1994: L Meyaard; Sigrid A Otto; IP Keet; René A W van Lier; Frank Miedema
Changes in cytokine secretion patterns of CD4+ T-cell clones in human immunodeficiency virus infection.
Blood 1994;84(12):4262-8.
1994: A C Lankester; G M van Schijndel; P M Rood; Arthur J Verhoeven; René A W van Lier
B cell antigen receptor cross-linking induces tyrosine phosphorylation and membrane translocation of a multimeric Shc complex that is augmented by CD19 co-ligation.
European journal of immunology 1994;24(11):2818-25.
1994: H M Kuiper; R de Jong; Mieke C Brouwer; Karen Lammers; J Wijdenes; René A W van Lier
Influence of CD28 co-stimulation on cytokine production is mainly regulated via interleukin-2.
Immunology 1994;83(1):38-44.
1994: H Kuiper; Mieke C Brouwer; M de Boer; P Parren; René A W van Lier
Differences in responsiveness to CD3 stimulation between naive and memory CD4+ T cells cannot be overcome by CD28 costimulation.
European journal of immunology 1994;24(9):1956-60.
1994: R Q Hintzen; R de Jong; SM Lens; René A W van Lier
CD27: marker and mediator of T-cell activation?
Immunology today 1994;15(7):307-11.
1994: Martijn Rep; R Q Hintzen; Chris H Polman; René A W van Lier
Functional defects in peripheral blood T cells of multiple sclerosis patients. Diminished in vitro responsiveness in accessory cell dependent activation systems.
Journal of neuroimmunology 1994;52(2):139-46.
1994: F J van Kemenade; E Tellegen; MM Maurice; A C Lankester; Taco W Kuijpers; Mieke C Brouwer; R de Jong; Frank Miedema; René A W van Lier
Simultaneous regulation of CD2 adhesion and signaling functions by a novel CD2 monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4425-32.
1994: A C Lankester; G M van Schijndel; J L Cordell; Carel J M van Noesel; René A W van Lier
CD5 is associated with the human B cell antigen receptor complex.
European journal of immunology 1994;24(4):812-6.
1994: R Q Hintzen; SM Lens; Gerrit Koopman; Steven T Pals; H Spits; René A W van Lier
CD70 represents the human ligand for CD27.
International immunology 1994;6(3):477-80.
1994: A C Lankester; G M van Schijndel; J Frommé; J L Cordell; René A W van Lier; Carel J M van Noesel
Evidence for a direct physical interaction of membrane IgM, IgD, and IgG with the B29 gene product.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2157-62.
1994: R Q Hintzen; SM Lens; M P Beckmann; RG Goodwin; D Lynch; René A W van Lier
Characterization of the human CD27 ligand, a novel member of the TNF gene family.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1762-73.
1993: Marinus H J van Oers; Steven T Pals; Ludo M Evers; C Ellen van der Schoot; Gerrit Koopman; J M Bonfrer; R Q Hintzen; Albert E G Kr von dem Borne; René A W van Lier
Expression and release of CD27 in human B-cell malignancies.
Blood 1993;82(11):3430-6.
1993: Maria Yazdanbakhsh; Erliyani Sartono; Yvonne C M Kruize; A Kurniawan; T van der Pouw-Kraan; P H van der Meide; Murray E Selkirk; F Partono; R Q Hintzen; René A W van Lier
Elevated levels of T cell activation antigen CD27 and increased interleukin-4 production in human lymphatic filariasis.
European journal of immunology 1993;23(12):3312-7.
1993: Peter Portegies; M H Godfried; R Q Hintzen; J Stam; Tom van der Poll; Margreet Bakker; Sander J H van Deventer; René A W van Lier; Jaap Goudsmit
Low levels of specific T cell activation marker CD27 accompanied by elevated levels of markers for non-specific immune activation in the cerebrospinal fluid of patients with AIDS dementia complex.
Journal of neuroimmunology 1993;48(2):241-7.
1993: M J Flens; W M Mulder; H Bril; M B von Blomberg van de Flier; R J Scheper; René A W van Lier
Efficient expansion of tumor-infiltrating lymphocytes from solid tumors by stimulation with combined CD3 and CD28 monoclonal antibodies.
Cancer immunology, immunotherapy : CII 1993;37(5):323-8.
1993: B E Hol; R Q Hintzen; René A W van Lier; C Alberts; Theo A Out; Henk M Jansen
Soluble and cellular markers of T cell activation in patients with pulmonary sarcoidosis.
The American review of respiratory disease 1993;148(3):643-9.
1993: A C Lankester; Carel J M van Noesel; G M van Schijndel; René A W van Lier
Surface expression of immunoglobulin isotypes on primary human B cells: no evidence for glycosyl-phosphatidylinositol linkage.
Immunology 1993;80(1):45-50.
1993: R Q Hintzen; R de Jong; SM Lens; M Brouwer; Paul A Baars; René A W van Lier
Regulation of CD27 expression on subsets of mature T-lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2426-35.
1993: Carel J M van Noesel; René A W van Lier
Architecture of the human B-cell antigen receptors.
Blood 1993;82(2):363-73.
1993: G J Jochems; Richard Bende; Michel Klein; W P Zeijlemaker; René A W van Lier
Expression of the IL-6 gene induces differentiation of a human monoclonal EBV-transformed B cell line.
Human antibodies and hybridomas 1993;4(3):124-33.
1993: Carel J M van Noesel; A C Lankester; G M van Schijndel; René A W van Lier
The CR2/CD19 complex on human B cells contains the src-family kinase Lyn.
International immunology 1993;5(7):699-705.
1993: Gaby Brouns; Evert de Vries; Carel J M van Noesel; David Y Mason; René A W van Lier; Jannie Borst
The structure of the mu/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction.
European journal of immunology 1993;23(5):1088-97.
1993: F J van Kemenade; K C Kuijpers; R de Waal-Malefijt; René A W van Lier; Frank Miedema
Skewing to the LFA-3 adhesion pathway by influenza infection of antigen-presenting cells.
European journal of immunology 1993;23(3):635-9.
1993: Carel J M van Noesel; A C Lankester; René A W van Lier
Dual antigen recognition by B cells.
Immunology today 1993;14(1):8-11.
1992: K C Kuijpers; Jacques J M van Dongen; P van der Burg; Marijke Th L Roos; J Vonk; Ronney A De Abreu; D de Korte; Carel J M van Noesel; Ron S Weening; René A W van Lier
A combined immunodeficiency with oligoclonal CD8+, V beta 3-expressing, cytotoxic T lymphocytes in the peripheral blood.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3403-10.
1992: M E Chamuleau; Ineke J M ten Berge; P T A Schellekens; J M Wilmink; R Q Hintzen; René A W van Lier
Serum levels of soluble CD27 in renal transplant recipients.
Transplantation 1992;54(5):932-6.
1992: R de Jong; Mieke C Brouwer; H M Kuiper; Berend Hooibrink; Frank Miedema; René A W van Lier
Maturation- and differentiation-dependent responsiveness of human CD4+ T helper subsets.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2795-802.
1992: David Y Mason; Carel J M van Noesel; J L Cordell; W Marieke Comans-Bitter; K Micklem; A G Tse; René A W van Lier; Jacques J M van Dongen
The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation.
European journal of immunology 1992;22(10):2753-6.
1992: G J Jochems; Michel Klein; W P Zeijlemaker; René A W van Lier
Protein kinase C regulates secretion of lymphotoxin (LT/TNF beta) and TNF alpha by human EBV-transformed B cells.
Human antibodies and hybridomas 1992;3(4):162-7.
1992: K C Kuijpers; F J van Kemenade; Berend Hooibrink; Jacques Neefjes; C J Lucas; René A W van Lier; Frank Miedema
HLA class I and II molecules present influenza virus antigens with different kinetics.
European journal of immunology 1992;22(9):2339-45.
1992: Richard Bende; G J Jochems; T H Frame; Michel Klein; R V van Eijk; René A W van Lier; W P Zeijlemaker
Effects of IL-4, IL-5, and IL-6 on growth and immunoglobulin production of Epstein-Barr virus-infected human B cells.
Cellular immunology 1992;143(2):310-23.
1992: R Q Hintzen; Chris H Polman; C J Lucas; René A W van Lier
Multiple sclerosis: immunological findings and possible implications for therapy.
Journal of neuroimmunology 1992;39(1-2):1-10.
1992: Carel J M van Noesel; Gaby Brouns; G M van Schijndel; Richard Bende; David Y Mason; Jannie Borst; René A W van Lier
Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers.
The Journal of experimental medicine 1992;175(6):1511-9.
1992: R De Jong; Mieke C Brouwer; Berend Hooibrink; T Van der Pouw-Kraan; Frank Miedema; René A W van Lier
The CD27- subset of peripheral blood memory CD4+ lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo.
European journal of immunology 1992;22(4):993-9.
1992: W A Loenen; Evert de Vries; LA Gravestein; R Q Hintzen; René A W van Lier; Jannie Borst
The CD27 membrane receptor, a lymphocyte-specific member of the nerve growth factor receptor family, gives rise to a soluble form by protein processing that does not involve receptor endocytosis.
European journal of immunology 1992;22(2):447-55.
1991: R Q Hintzen; René A W van Lier; K C Kuijpers; Paul A Baars; Wim Schaasberg; C J Lucas; Chris H Polman
Elevated levels of a soluble form of the T cell activation antigen CD27 in cerebrospinal fluid of multiple sclerosis patients.
Journal of neuroimmunology 1991;35(1-3):211-7.
1991: Eddy A Wierenga; M Snoek; Henk M Jansen; Jan D Bos; René A W van Lier; Martien L Kapsenberg
Human atopen-specific types 1 and 2 T helper cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):2942-9.
1991: S S Weinreich; Albert E G Kr von dem Borne; René A W van Lier; C A Feltkamp; R M Slater; M R Wester; W P Zeijlemaker
Characterization of a human plasmacytoma line.
British journal of haematology 1991;79(2):226-34.
1991: R de Jong; P Stokkers; Evert Lamme; J M Kool; F Borst; Mieke C Brouwer; Frank Miedema; René A W van Lier
Regulation of T-cell differentiation by CD2 and CD28 accessory molecules.
Immunology 1991;74(2):175-82.
1991: Rob A Gruters; F G Terpstra; R E De Goede; J W Mulder; Frank de Wolf; P T A Schellekens; René A W van Lier; M Tersmette; Frank Miedema
Immunological and virological markers in individuals progressing from seroconversion to AIDS.
AIDS (London, England) 1991;5(7):837-44.
1991: René A W van Lier; Mieke C Brouwer; E D De Groot; I Kramer; Lucien A Aarden; Arthur J Verhoeven
T cell receptor/CD3 and CD28 use distinct intracellular signaling pathways.
European journal of immunology 1991;21(7):1775-8.
1991: R Q Hintzen; R de Jong; C Erik Hack; M Chamuleau; E F de Vries; Ineke J M ten Berge; Jannie Borst; René A W van Lier
A soluble form of the human T cell differentiation antigen CD27 is released after triggering of the TCR/CD3 complex.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(1):29-35.
1991: Carel J M van Noesel; René A W van Lier; J L Cordell; A G Tse; G M van Schijndel; E F de Vries; David Y Mason; Jannie Borst
The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(11):3881-8.
1991: R de Jong; W A Loenen; Mieke C Brouwer; L van Emmerik; E F de Vries; Jannie Borst; René A W van Lier
Regulation of expression of CD27, a T cell-specific member of a novel family of membrane receptors.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(8):2488-94.
1991: R de Jong; Mieke C Brouwer; Frank Miedema; René A W van Lier
Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2088-94.
1991: G J Jochems; Michel Klein; R Jordens; D Pascual-Salcedo; F van Boxtel-Oosterhof; René A W van Lier; W P Zeijlemaker
Heterogeneity in both cytokine production and responsiveness of a panel of monoclonal human Epstein-Barr virus-transformed B-cell lines.
Human antibodies and hybridomas 1991;2(2):57-64.
1991: Rob A Gruters; S A Otto; B J Al; Arthur J Verhoeven; Cornelis L Verweij; René A W van Lier; Frank Miedema
Non-mitogenic T cell activation signals are sufficient for induction of human immunodeficiency virus transcription.
European journal of immunology 1991;21(1):167-72.
1991: Menno A de Rie; FF Hamerlinck; R Q Hintzen; Jan D Bos; René A W van Lier
Quantitation of soluble CD27, a T-cell activation antigen, and soluble interleukin-2 receptor in serum from patients with psoriasis.
Archives of dermatological research 1991;283(8):533-4.
1990: Carel J M van Noesel; Jannie Borst; E F De Vries; René A W van Lier
Identification of two distinct phosphoproteins as components of the human B cell antigen receptor complex.
European journal of immunology 1990;20(12):2789-93.
1990: R De Jong; Mieke C Brouwer; Vivienne Rebel; Gijs A van Seventer; Frank Miedema; René A W van Lier
Generation of alloreactive cytolytic T lymphocytes by immobilized anti-CD3 monoclonal antibodies. Analysis of requirements for human cytolytic T-lymphocyte differentiation.
Immunology 1990;70(3):357-64.
1990: Carel J M van Noesel; Rob A Gruters; F G Terpstra; P T A Schellekens; René A W van Lier; Frank Miedema
Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men.
The Journal of clinical investigation 1990;86(1):293-9.
1990: Rob A Gruters; F G Terpstra; R De Jong; Carel J M van Noesel; René A W van Lier; Frank Miedema
Selective loss of T cell functions in different stages of HIV infection. Early loss of anti-CD3-induced T cell proliferation followed by decreased anti-CD3-induced cytotoxic T lymphocyte generation in AIDS-related complex and AIDS.
European journal of immunology 1990;20(5):1039-44.
1990: K C Kuijpers; Taco W Kuijpers; W P Zeijlemaker; C J Lucas; René A W van Lier; Frank Miedema
Analysis of the role of leukocyte function-associated antigen-1 in activation of human influenza virus-specific T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3281-7.
1990: E W Nijhuis; E vd Wiel-van Kemenade; Carl Figdor; René A W van Lier
Activation and expansion of tumour-infiltrating lymphocytes by anti-CD3 and anti-CD28 monoclonal antibodies.
Cancer immunology, immunotherapy : CII 1990;32(4):245-50.
1990: G J Jochems; R Jordens; René A W van Lier; W P Zeijlemaker
Effect of IL-6 on proliferation and IG production of human EBV-transformed cell lines in serum free culture media.
Developments in biological standardization 1990;71():57-63.
1989: René A W van Lier; Mieke C Brouwer; Vivienne Rebel; Carel J M van Noesel; Lucien A Aarden
Immobilized anti-CD3 monoclonal antibodies induce accessory cell-independent lymphokine production, proliferation and helper activity in human T lymphocytes.
Immunology 1989;68(1):45-50.
1989: René A W van Lier; E Bloemena; Mieke C Brouwer; J Van Heijst; S Weinreich; L Aarden
Studies on the monocyte dependence of T-cell proliferation induced by monoclonal antibodies directed against regions I and II of the CD2 antigen.
Immunology 1989;67(3):333-8.
1989: E Bloemena; R H Van Oers; S Weinreich; A P Stilma-Meinesz; P T A Schellekens; René A W van Lier
The influence of cyclosporin A on the alternative pathways of human T cell activation in vitro.
European journal of immunology 1989;19(5):943-6.
1989: E Bloemena; René A W van Lier; Marinus H J van Oers; S Weinreich; A P Stilma-Meinesz; P T A Schellekens
The effects of prednisolone and cyclosporin A on monocyte-dependent and -independent human T-cell proliferation in vitro.
Transplantation proceedings 1989;21(1 Pt 1):861-5.
1989: Jannie Borst; C Sluyser; Evert de Vries; H Klein; Cornelis J M Melief; René A W van Lier
Alternative molecular form of human T cell-specific antigen CD27 expressed upon T cell activation.
European journal of immunology 1989;19(2):357-64.
1988: Gijs A van Seventer; René A W van Lier; K C Kuijpers; H Spits; Cornelis J M Melief
Regulatory role of the CD8 antigen in both CD3 and CD2 monoclonal antibody-induced nonspecific cytotoxicity of class I- and class II-allospecific cytotoxic T cell clones.
European journal of immunology 1988;18(12):1973-8.
1988: F T Rotteveel; I Kokkelink; René A W van Lier; B Kuenen; A Meager; Frank Miedema; C J Lucas
Clonal analysis of functionally distinct human CD4+ T cell subsets.
The Journal of experimental medicine 1988;168(5):1659-73.
1988: Carel J M van Noesel; Frank Miedema; Mieke C Brouwer; Menno A de Rie; Lucien A Aarden; René A W van Lier
Regulatory properties of LFA-1 alpha and beta chains in human T-lymphocyte activation.
Nature 1988;333(6176):850-2.
1988: René A W van Lier; M O Pool; P Kabel; S Mous; F Terpstra; Menno A de Rie; Cornelis J M Melief; Frank Miedema
Anti-CD27 monoclonal antibodies identify two functionally distinct subpopulations within the CD4+ T cell subset.
European journal of immunology 1988;18(5):811-6.
1988: A J Petit; M Tersmette; F G Terpstra; R E de Goede; René A W van Lier; Frank Miedema
Decreased accessory cell function by human monocytic cells after infection with HIV.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1485-9.
1987: René A W van Lier; J H Boot; Arthur J Verhoeven; Els R de Groot; Mieke C Brouwer; Lucien A Aarden
Functional studies with anti-CD3 heavy chain isotype switch-variant monoclonal antibodies. Accessory cell-independent induction of interleukin 2 responsiveness in T cells by epsilon-anti-CD3.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(9):2873-9.
1987: René A W van Lier; J H Boot; Els R de Groot; Lucien A Aarden
Induction of T cell proliferation with anti-CD3 switch-variant monoclonal antibodies: effects of heavy chain isotype in monocyte-dependent systems.
European journal of immunology 1987;17(11):1599-604.
1987: Gijs A van Seventer; K C Kuijpers; René A W van Lier; Els R de Groot; Lucien A Aarden; Cornelis J M Melief
Mechanism of inhibition and induction of cytolytic activity in cytotoxic T lymphocytes by CD3 monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2545-50.