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Maarten van Lohuizen

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Cell Transformation, Neoplastic

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Shihori Yokobayashi; Tim C Roloff; Maarten van Lohuizen; Miguel Vidal; Hubertus Kohler; Ching-Yeu Liang; Zichuan Liu; Peter Nestorov; Antoine H F M Peters
PRC1 coordinates timing of sexual differentiation of female primordial germ cells.
Dusan Zencak; Rod Bremner; Danian Chen; Per Ekström; Karine Schouwey; Ellen Tanger; Maarten van Lohuizen; Yvan Arsenijevic
Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins.
Bas Tolhuis; Marleen Blom; Maarten van Lohuizen
Chromosome conformation capture on chip in single Drosophila melanogaster tissues.

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2013: Shihori Yokobayashi; Tim C Roloff; Maarten van Lohuizen; Miguel Vidal; Hubertus Kohler; Ching-Yeu Liang; Zichuan Liu; Peter Nestorov; Antoine H F M Peters
PRC1 coordinates timing of sexual differentiation of female primordial germ cells.
Nature 2013;495(7440):236-40.
2013: Dusan Zencak; Rod Bremner; Danian Chen; Per Ekström; Karine Schouwey; Ellen Tanger; Maarten van Lohuizen; Yvan Arsenijevic
Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(7):E593-601.
2012: Bas Tolhuis; Marleen Blom; Maarten van Lohuizen
Chromosome conformation capture on chip in single Drosophila melanogaster tissues.
Methods (San Diego, Calif.) 2012;58(3):231-42.
2012: Joseph H A Vissers; Maarten van Lohuizen; Elisabetta Citterio
The emerging role of Polycomb repressors in the response to DNA damage.
Journal of cell science 2012;125(Pt 17):3939-48.
2012: Yme U van der Velden; Maarten van Lohuizen; Liqin Wang; Anna-Pavlina G Haramis
The Polycomb group protein Ring1b is essential for pectoral fin development.
Development (Cambridge, England) 2012;139(12):2210-20.
2012: Alireza Baradaran-Heravi; Kimberly Beirnes; Arend Bokenkamp; Darren Bridgewater; Kyoung Sang Cho; Kunho Choi; Kira Y Dionis; Leah I Elizondo; Hok Khim Fam; Yan Huang; Kory Keller; Danny Leung; David B Lewis; Joanna Lubieniecka; Thomas Lücke; Marco A Marra; Christy Mayfield; Marie Morimoto; Olena Morozova; Clara Myung; Mrinmoy Sanyal; Chad Shaw; Peter Stenzel; Bas Tolhuis; Maarten van Lohuizen; Jonathan Zonana; Cornelius F Boerkoel
Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression.
Human molecular genetics 2012;21(11):2572-87.
2012: Karim Nacerddine; Olga Balagué Ponz; Colin Pritchard; Titia K Sixma; Ji-Ying Song; Ellen Tanger; Henk van der Poel; Jean-Bernard Beaudry; Paulien Cornelissen-Steijger; Shridar Ganesan; Vasudeva Ginjala; Francesca Mattiroli; Bart Westerman; John Zevenhoven; Maarten van Lohuizen
Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.
The Journal of clinical investigation 2012;122(5):1920-32.
2012: Eszter Posfai; Tim C Roloff; Juliette Salvaing; Mathieu Tardat; Maarten van Lohuizen; Miguel Vidal; Nathalie Beaujean; Vincent Brochard; Erik Cabuy; Rico Kunzmann; Zichuan Liu; Antoine H F M Peters
Polycomb function during oogenesis is required for mouse embryonic development.
Genes & development 2012;26(9):920-32.
2012: Bart A Westerman; John Zevenhoven; Marije van Santen; Eleonora Aronica; Marleen Blom; Paulien Cornelissen-Steijger; Jules Gadiot; Haydn M Prosser; Ji-Ying Song; Ellen Tanger; Anthony Uren; Martin van der Valk; Maarten van Lohuizen
GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors.
PloS one 2012;7(5):e35943.
2011: Johann de Jong; Jeroen de Ridder; Jos Jonkers; Ning Sun; Louise van der Weyden; Maarten van Lohuizen; Miranda van Uitert; David J Adams; Anton Berns; Lodewyk F A Wessels
Computational identification of insertional mutagenesis targets for cancer gene discovery.
Nucleic acids research 2011;39(15):e105.
2011: Lan-Lan Smith; Jenny Yeung; Bernd B Zeisig; Nikolay Popov; Ivo Huijbers; Josephine Barnes; Amanda J Wilson; Erdogan Taskesen; Ruud Delwel; Jesús Gil; Maarten van Lohuizen; Chi Wai Eric So
Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells.
Cell stem cell 2011;8(6):649-62.
2011: Vasudeva Ginjala; Karim Nacerddine; Atul Kulkarni; Jay Oza; Sarah J Hill; Ming Yao; Elisabetta Citterio; Maarten van Lohuizen; Shridar Ganesan
BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair.
Molecular and cellular biology 2011;31(10):1972-82.
2011: Yme U van der Velden; Liqin Wang; John Zevenhoven; Ellen van Rooijen; Maarten van Lohuizen; Rachel H Giles; Hans Clevers; Anna-Pavlina G Haramis
The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(11):4358-63.
2011: Bas Tolhuis; Marleen Blom; Ron Kerkhoven; Ludo Pagie; Hans Teunissen; Marja Nieuwland; Marieke Simonis; Wouter de Laat; Maarten van Lohuizen; Bas van Steensel
Interactions among Polycomb domains are guided by chromosome architecture.
PLoS genetics 2011;7(3):e1001343.
2010: Nienke A de Vries; Sophia W Bruggeman; Danielle Hulsman; Hilda I de Vries; John Zevenhoven; Tessa Buckle; Bob C Hamans; William P Leenders; Jos H Beijnen; Maarten van Lohuizen; Anton J M Berns; Olaf van Tellingen
Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(13):3431-41.
2010: Daan Peric-Hupkes; Wouter Meuleman; Ludo Pagie; Sophia W M Bruggeman; Irina Solovei; Wim Brugman; Stefan Gräf; Paul Flicek; Ron Kerkhoven; Maarten van Lohuizen; Marcel J T Reinders; Lodewyk Wessels; Bas van Steensel
Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation.
Molecular cell 2010;38(4):603-13.
2010: Jenny Mattison; Jaap Kool; Anthony G Uren; Jeroen de Ridder; Lodewyk Wessels; Jos Jonkers; Graham R Bignell; Adam Butler; Alistair G Rust; Markus Brosch; Catherine H Wilson; Louise van der Weyden; David A Largaespada; Michael R Stratton; P Andrew Futreal; Maarten van Lohuizen; Anton Berns; Lara S Collier; Tim Hubbard; David J Adams
Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach.
Cancer research 2010;70(3):883-95.
2010: Jaap Kool; Anthony Uren; Carla P Martins; Daoud Sie; Jeroen de Ridder; Geoffrey Turner; Miranda van Uitert; Konstantin Matentzoglu; Wendy Lagcher; Paul Krimpenfort; Jules Gadiot; Colin Pritchard; Jack Lenz; Anders H Lund; Jos Jonkers; Jane Rogers; David J Adams; Lodewyk Wessels; Anton Berns; Maarten van Lohuizen
Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.
Cancer research 2010;70(2):520-31.
2009: Jie Liu; Liu Cao; Jichun Chen; Shiwei Song; In Hye Lee; Celia Quijano; Hongjun Liu; Keyvan Keyvanfar; Haoqian Chen; Long-Yue Cao; Bong-Hyun Ahn; Neil G Kumar; Ilsa I Rovira; Xiao-Ling Xu; Maarten van Lohuizen; Noboru Motoyama; Chu-Xia Deng; TOREN FINKEL
Bmi1 regulates mitochondrial function and the DNA damage response pathway.
Nature 2009;459(7245):387-92.
2009: Hanane Boukarabila; Andrew J Saurin; Eric Batsché; Noushine Mossadegh; Maarten van Lohuizen; Arie P Otte; Jacques Pradel; Christian Muchardt; Michael Sieweke; Estelle Duprez
The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation.
Genes & development 2009;23(10):1195-206.
2009: Sophia W M Bruggeman; Danielle Hulsman; Maarten van Lohuizen
Bmi1 deficient neural stem cells have increased integrin dependent adhesion to self-secreted matrix.
Biochimica et biophysica acta 2009;1790(5):351-60.
2009: Bernd Schuettengruber; Mythily Ganapathi; Benjamin Leblanc; Manuela Portoso; Rami Jaschek; Bas Tolhuis; Maarten van Lohuizen; Amos Tanay; Giacomo Cavalli
Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos.
PLoS biology 2009;7(1):e13.
2009: Julian Puppe; Rinske Drost; Xiaoling Liu; Simon A Joosse; Bastiaan Evers; Paulien Cornelissen-Steijger; petra nederlof; Qiang Yu; Jos Jonkers; Maarten van Lohuizen; Alexandra M Pietersen
BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.
Breast cancer research : BCR 2009;11(4):R63.
2009: Anthony Uren; Harald Mikkers; Jaap Kool; Louise van der Weyden; Anders H Lund; Catherine H Wilson; Richard Rance; Jos Jonkers; Maarten van Lohuizen; Anton Berns; David J Adams
A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites.
Nature protocols 2009;4(5):789-98.
2009: Alexandre Prieur; Karim Nacerddine; Maarten van Lohuizen; Daniel S Peeper
SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes.
PloS one 2009;4(5):e5542.
2008: Lowell Evan Michael; Bart A Westerman; Alexandre N Ermilov; Aiqin Wang; Jennifer Ferris; Jianhong Liu; Marleen Blom; David W Ellison; Maarten van Lohuizen; Andrzej Dlugosz
Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion.
Neoplasia (New York, N.Y.) 2008;10(12):1343-9, 5p following 1349.
2008: Panthea Taghavi; Els Verhoeven; Jacqueline J L Jacobs; J P Lambooij; Catelijne Stortelers; Ellen Tanger; Wouter H Moolenaar; Maarten van Lohuizen
In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.
Oncogene 2008;27(54):6806-16.
2008: Rémi Terranova; Shihori Yokobayashi; Michael B Stadler; Arie P Otte; Maarten van Lohuizen; Stuart H Orkin; Antoine H F M Peters
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos.
Developmental cell 2008;15(5):668-79.
2008: Alexandra M Pietersen; Bastiaan Evers; Asheeta A Prasad; Ellen Tanger; Paulien Cornelissen-Steijger; Jos Jonkers; Maarten van Lohuizen
Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium.
Current biology : CB 2008;18(14):1094-9.
2008: Anthony Uren; Jaap Kool; Konstantin Matentzoglu; Jeroen de Ridder; Jenny Mattison; Miranda van Uitert; Wendy Lagcher; Daoud Sie; Ellen Tanger; Tony Cox; Marcel J T Reinders; Tim Hubbard; Jane Rogers; Jos Jonkers; Lodewyk F A Wessels; David J Adams; Maarten van Lohuizen; Anton Berns
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.
Cell 2008;133(4):727-41.
2008: Mareike Puschendorf; Rémi Terranova; Erwin Boutsma; Xiaohong Mao; Kyo-ichi Isono; Urszula Brykczynska; Carolin Kolb; Arie P Otte; Haruhiko Koseki; Stuart H Orkin; Maarten van Lohuizen; Antoine H F M Peters
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.
Nature genetics 2008;40(4):411-20.
2008: Alexandra M Pietersen; Maarten van Lohuizen
Stem cell regulation by polycomb repressors: postponing commitment.
Current opinion in cell biology 2008;20(2):201-7.
2008: Masaki Miyazaki; Kazuko Miyazaki; Manami Itoi; Yuko Katoh; Yun Guo; Rieko Kanno; Yuko Katoh-Fukui; Hiroaki Honda; Takashi Amagai; Maarten van Lohuizen; Hiroshi Kawamoto; Masamoto Kanno
Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression.
Immunity 2008;28(2):231-45.
2008: Alexandra M Pietersen; Hugo M Horlings; Michael Hauptmann; Anita Langerød; Abderrahim Ajouaou; Paulien Cornelissen-Steijger; Lodewyk F A Wessels; Jos Jonkers; Marc J van de Vijver; Maarten van Lohuizen
EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer.
Breast cancer research : BCR 2008;10(6):R109.
2008: Erwin Boutsma; Sonja Noback; Maarten van Lohuizen
The Polycomb protein and E3 ubiquitin ligase Ring1B harbors an IRES in its highly conserved 5' UTR.
PloS one 2008;3(6):e2322.
2008: Petra van der Stoop; Erwin A Boutsma; Danielle Hulsman; Sonja Noback; Mike Heimerikx; Ron Kerkhoven; J Willem Voncken; Lodewyk F A Wessels; Maarten van Lohuizen
Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.
PloS one 2008;3(5):e2235.
2008: Joseph Ha Vissers; francesco nicassio; Maarten van Lohuizen; Pier Paolo Di Fiore; Elisabetta Citterio
The many faces of ubiquitinated histone H2A: insights from the DUBs.
Cell division 2008;3():8.
2007: Sophia W M Bruggeman; Danielle Hulsman; Ellen Tanger; Tessa Buckle; Marleen Blom; John Zevenhoven; Olaf van Tellingen; Maarten van Lohuizen
Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.
Cancer cell 2007;12(4):328-41.
2006: Hiroyuki Hosokawa; Motoko Y Kimura; Ryo Shinnakasu; Akane Suzuki; Takako Miki; Haruhiko Koseki; Maarten van Lohuizen; Masakatsu Yamashita; Toshinori Nakayama
Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7656-64.
2006: Anke Sparmann; Maarten van Lohuizen
Polycomb silencers control cell fate, development and cancer.
Nature reviews. Cancer 2006;6(11):846-56.
2006: Hideyuki Oguro; Atsushi Iwama; Yohei Morita; Takehiko Kamijo; Maarten van Lohuizen; Hiromitsu Nakauchi
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice.
The Journal of experimental medicine 2006;203(10):2247-53.
2006: Vincenzo Pirrotta; Maarten van Lohuizen
Differentiation and gene regulation. Genomic programs and differentiation: editorial overview.
Current opinion in genetics & development 2006;16(5):443-6.
2006: Gretel Buchwald; Petra van der Stoop; Oliver Weichenrieder; Anastassis Perraks; Maarten van Lohuizen; Titia K Sixma
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.
The EMBO journal 2006;25(11):2465-74.
2006: Sophia W M Bruggeman; Maarten van Lohuizen
Controlling stem cell proliferation: CKIs at work.
Cell cycle (Georgetown, Tex.) 2006;5(12):1281-5.
2006: Yu-ichi Fujimura; Kyo-ichi Isono; Miguel Vidal; Mitsuhiro Endoh; Hiroshi Kajita; Yoko Mizutani-Koseki; Yoshihiro Takihara; Maarten van Lohuizen; Arie Otte; Thomas Jenuwein; Jacqueline Deschamps; Haruhiko Koseki
Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8.
Development (Cambridge, England) 2006;133(12):2371-81.
2006: Bas Tolhuis; Elzo de Wit; Inhua Muijrers; Hans Teunissen; Wendy Talhout; Bas van Steensel; Maarten van Lohuizen
Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster.
Nature genetics 2006;38(6):694-9.
2006: Panthea Taghavi; Maarten van Lohuizen
Developmental biology: two paths to silence merge.
Nature 2006;439(7078):794-5.
2006: Dusan Zencak; Sylvain V Crippa; Meriem Tekaya; Ellen Tanger; Daniel E Schorderet; Francis L Munier; Maarten van Lohuizen; Yvan Arsenijevic
BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice.
Advances in experimental medicine and biology 2006;572():209-15.
2005: Inmaculada Hernández-Muñoz; Panthea Taghavi; Coenraad Kuijl; Jacques Neefjes; Maarten van Lohuizen
Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1.
Molecular and cellular biology 2005;25(24):11047-58.
2005: Anthony Uren; J Kool; Anton Berns; Maarten van Lohuizen
Retroviral insertional mutagenesis: past, present and future.
Oncogene 2005;24(52):7656-72.
2005: Sophia W M Bruggeman; Merel E Valk-Lingbeek; Petra van der Stoop; Jacqueline J L Jacobs; Karin Kieboom; Ellen Tanger; Danielle Hulsman; Carly Leung; Yvan Arsenijevic; Silvia Marino; Maarten van Lohuizen
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.
Genes & development 2005;19(12):1438-43.
2005: Dusan Zencak; Merel Lingbeek; Corinne Kostic; Meriem Tekaya; Ellen Tanger; Dana Hornfeld; Muriel Jaquet; Francis L Munier; Daniel F Schorderet; Maarten van Lohuizen; Yvan Arsenijevic
Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(24):5774-83.
2005: Inmaculada Hernández-Muñoz; Anders H Lund; Petra van der Stoop; Erwin Boutsma; Inhua Muijrers; Els Verhoeven; Dmitri A Nusinow; Barbara Panning; York Marahrens; Maarten van Lohuizen
Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7635-40.
2004: Atsushi Iwama; Hideyuki Oguro; Masamitsu Negishi; Yuko Kato; Youhei Morita; Hiroko Tsukui; Hideo Ema; Takehiko Kamijo; Yuko Katoh-Fukui; Haruhiko Koseki; Maarten van Lohuizen; Hiromitsu Nakauchi
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1.
Immunity 2004;21(6):843-51.
2004: Anders H Lund; Maarten van Lohuizen
Epigenetics and cancer.
Genes & development 2004;18(19):2315-35.
2004: Merel E Valk-Lingbeek; Sophia W M Bruggeman; Maarten van Lohuizen
Stem cells and cancer; the polycomb connection.
Cell 2004;118(4):409-18.
2004: Marissa J Carstens; Andrea Krempler; Aleata A Triplett; Maarten van Lohuizen; Kay-Uwe Wagner
Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells.
The Journal of biological chemistry 2004;279(34):35984-94.
2004: Anders H Lund; Maarten van Lohuizen
Polycomb complexes and silencing mechanisms.
Current opinion in cell biology 2004;16(3):239-46.
2004: Carly Leung; Merel Lingbeek; Olga Shakhova; James Liu; Ellen Tanger; Parvin Saremaslani; Maarten van Lohuizen; Silvia Marino
Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas.
Nature 2004;428(6980):337-41.
2004: I Muyrers-Chen; Inmaculada Hernández-Muñoz; Anders H Lund; Merel E Valk-Lingbeek; Petra van der Stoop; E Boutsma; Bas Tolhuis; Sophia W M Bruggeman; Panthea Taghavi; Els Verhoeven; Danielle Hulsman; S Noback; Ellen Tanger; H Theunissen; Maarten van Lohuizen
Emerging roles of Polycomb silencing in X-inactivation and stem cell maintenance.
Cold Spring Harbor symposia on quantitative biology 2004;69():319-26.
2003: Kamil R Kranc; Simon D Bamforth; Jose Bragança; Chris Norbury; Maarten van Lohuizen; Shoumo Bhattacharya
Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.
Molecular and cellular biology 2003;23(21):7658-66.
2003: Kevin S Smith; Sumit K Chanda; Merel Lingbeek; Douglas T Ross; David Botstein; Maarten van Lohuizen; Michael L Cleary
Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1.
Molecular cell 2003;12(2):393-400.
2003: Jan Willem Voncken; Bernard A J Roelen; Mieke Roefs; Stijn de Vries; Els Verhoeven; Silvia Marino; Jacqueline Deschamps; Maarten van Lohuizen
Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2468-73.
2003: Koji Itahana; Ying Zou; Yoko Itahana; Jose-Luis Martinez; Christian M Beausejour; Jacqueline J L Jacobs; Maarten van Lohuizen; Vimla Band; Judith Campisi; Goberdhan P Dimri
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.
Molecular and cellular biology 2003;23(1):389-401.
2002: Anders H Lund; Geoffrey Turner; Alla Trubetskoy; Els Verhoeven; Ellen Wientjens; Danielle Hulsman; Robert Russell; Ronald A DePinho; Jack Lenz; Maarten van Lohuizen
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice.
Nature genetics 2002;32(1):160-5.
2002: Goberdhan P Dimri; Jose-Luis Martinez; Jacqueline J L Jacobs; Petra Keblusek; Koji Itahana; Maarten van Lohuizen; Judith Campisi; David E Wazer; Vimla Band
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells.
Cancer research 2002;62(16):4736-45.
2002: Merel Lingbeek; Jacqueline J L Jacobs; Maarten van Lohuizen
The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator.
The Journal of biological chemistry 2002;277(29):26120-7.
2002: Jacqueline J L Jacobs; Maarten van Lohuizen
Polycomb repression: from cellular memory to cellular proliferation and cancer.
Biochimica et biophysica acta 2002;1602(2):151-61.
2002: Petra E M H Habets; Antoon F M Moorman; Danielle E W Clout; Marian A van Roon; Merel Lingbeek; Maarten van Lohuizen; Marina Campione; Vincent M Christoffels
Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation.
Genes & development 2002;16(10):1234-46.
2002: Anders H Lund; Maarten van Lohuizen
RUNX: a trilogy of cancer genes.
Cancer cell 2002;1(3):213-5.
2002: Thijn R Brummelkamp; Roderik M Kortlever; Merel Lingbeek; Flavia Trettel; Marcy E MacDonald; Maarten van Lohuizen; René Bernards
TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.
The Journal of biological chemistry 2002;277(8):6567-72.
2001: Takeshi Akasaka; Maarten van Lohuizen; NM Van der Lugt; Yoko Mizutani-Koseki; M Kanno; Masaru Taniguchi; Miguel Vidal; MJ Alkema; Anton Berns; Haruhiko Koseki
Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression.
Development (Cambridge, England) 2001;128(9):1587-97.
2000: Jacqueline J L Jacobs; P Keblusek; Els C Robanus-Maandag; Petra M P Kristel; Merel Lingbeek; petra nederlof; Tibor van Welsem; Marc J van de Vijver; Eugene Koh; George Q Daley; Maarten van Lohuizen
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.
Nature genetics 2000;26(3):291-9.
2000: Tara McMorrow; A van den Wijngaard; A Wollenschlaeger; Mariette van de Corput; K Monkhorst; T Trimborn; P Fraser; Maarten van Lohuizen; T Jenuwein; Malek Djabali; Sjaak Philipsen; Frank Grosveld; E Milot
Activation of the beta globin locus by transcription factors and chromatin modifiers.
The EMBO journal 2000;19(18):4986-96.
1999: Jan Willem Voncken; Dieter Schweizer; L Aagaard; L Sattler; Michael F Jantsch; Maarten van Lohuizen
Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status.
Journal of cell science 1999;112 ( Pt 24)():4627-39.
1999: Julie Lessard; A Schumacher; Unnur Thorsteinsdottir; Maarten van Lohuizen; Terry Magnuson; Guy Sauvageau
Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation.
Genes & development 1999;13(20):2691-703.
1999: Jacqueline J L Jacobs; Blanca Scheijen; Jan Willem Voncken; Karin Kieboom; Anton Berns; Maarten van Lohuizen
Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.
Genes & development 1999;13(20):2678-90.
1999: Maarten van Lohuizen
The trithorax-group and polycomb-group chromatin modifiers: implications for disease.
Current opinion in genetics & development 1999;9(3):355-61.
1999: J J Jacobs; Maarten van Lohuizen
Cellular memory of transcriptional states by Polycomb-group proteins.
Seminars in cell & developmental biology 1999;10(2):227-35.
1999: Jacqueline J L Jacobs; Karin Kieboom; Silvia Marino; Ronald A DePinho; Maarten van Lohuizen
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.
Nature 1999;397(6715):164-8.
1998: S Bel; Nathalie Coré; Malek Djabali; Karin Kieboom; NM Van der Lugt; MJ Alkema; Maarten van Lohuizen
Genetic interactions and dosage effects of Polycomb group genes in mice.
Development (Cambridge, England) 1998;125(18):3543-51.
1998: Maarten van Lohuizen; M Tijms; Jan Willem Voncken; A Schumacher; Terry Magnuson; Ellen Wientjens
Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.
Molecular and cellular biology 1998;18(6):3572-9.
1998: Maarten van Lohuizen
Functional analysis of mouse Polycomb group genes.
Cellular and molecular life sciences : CMLS 1998;54(1):71-9.
1997: MJ Alkema; J Jacobs; Jan Willem Voncken; N A Jenkins; N G Copeland; David P E Satijn; A P Otte; A Berns; Maarten van Lohuizen
MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex.
Journal of molecular biology 1997;273(5):993-1003.
1997: MJ Alkema; Heinz Jacobs; Maarten van Lohuizen; Anton Berns
Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger.
Oncogene 1997;15(8):899-910.
1997: MJ Gunster; David P E Satijn; Karien M Hamer; Jan L den Blaauwen; Diederik R H de Bruijn; MJ Alkema; Maarten van Lohuizen; Roel Van Driel; Arie P Otte
Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.
Molecular and cellular biology 1997;17(4):2326-35.
1997: MJ Alkema; Marieke Bronk; Els Verhoeven; A Otte; Laura J van 't Veer; Anton Berns; Maarten van Lohuizen
Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.
Genes & development 1997;11(2):226-40.
1995: MJ Alkema; N M van der Lugt; R C Bobeldijk; Anton Berns; Maarten van Lohuizen
Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice.
Nature 1995;374(6524):724-7.
1994: N M van der Lugt; J Domen; K Linders; M van Roon; Els C Robanus-Maandag; Hein te Riele; Martin van der Valk; J Deschamps; M Sofroniew; Maarten van Lohuizen
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.
Genes & development 1994;8(7):757-69.
1994: Anton Berns; N van der Lugt; MJ Alkema; Maarten van Lohuizen; J Domen; D Acton; J Allen; P W Laird; Jos Jonkers
Mouse model systems to study multistep tumorigenesis.
Cold Spring Harbor symposia on quantitative biology 1994;59():435-47.
1993: MJ Alkema; J Wiegant; A K Raap; Anton Berns; Maarten van Lohuizen
Characterization and chromosomal localization of the human proto-oncogene BMI-1.
Human molecular genetics 1993;2(10):1597-603.
1991: Maarten van Lohuizen; Manfred Frasch; E Wientjens; Anton Berns
Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2.
Nature 1991;353(6342):353-5.
1991: Maarten van Lohuizen; S Verbeek; Blanca Scheijen; E Wientjens; H van der Gulden; Anton Berns
Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging.
Cell 1991;65(5):737-52.
1991: S Verbeek; Maarten van Lohuizen; Martin van der Valk; J Domen; G Kraal; Anton Berns
Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.
Molecular and cellular biology 1991;11(2):1176-9.
1990: Maarten van Lohuizen; Anton Berns
Tumorigenesis by slow-transforming retroviruses--an update.
Biochimica et biophysica acta 1990;1032(2-3):213-35.
1989: M Breuer; RJ Slebos; S Verbeek; Maarten van Lohuizen; E Wientjens; Anton Berns
Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice.
Nature 1989;340(6228):61-3.
1989: Maarten van Lohuizen; S Verbeek; Paul Krimpenfort; J Domen; C Saris; T Radaszkiewicz; Anton Berns
Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors.
Cell 1989;56(4):673-82.
1989: Anton Berns; M Breuer; S Verbeek; Maarten van Lohuizen
Transgenic mice as a means to study synergism between oncogenes.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1989;4():22-5.
1989: Maarten van Lohuizen; M Breuer; Anton Berns
N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas.
The EMBO journal 1989;8(1):133-6.