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S A P van Luxemburg-Heijs

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Caroline E Rutten; Cornelis A M van Bergen; S A P van Luxemburg-Heijs; Marieke Griffioen; Constantijn J M Halkes; Erik W A Marijt; Machteld Oudshoorn; J H Frederik Falkenburg
Patient HLA-DP-specific CD4+ T cells from HLA-DPB1-mismatched donor lymphocyte infusion can induce graft-versus-leukemia reactivity in the presence or absence of graft-versus-host disease.
Marieke Griffioen; M Willy Honders; Michel Kester; Ellie G A Lurvink; Cornelis A M van Bergen; Els van der Meijden; S A P van Luxemburg-Heijs; J H Frederik Falkenburg
Identification of 4 novel HLA-B*40:01 restricted minor histocompatibility antigens and their potential as targets for graft-versus-leukemia reactivity.
Cornelis A M van Bergen; Caroline E Rutten; Els van der Meijden; S A P van Luxemburg-Heijs; Ellie G A Lurvink; Jeanine J Houwing-Duistermaat; Michel Kester; Arend Mulder; Roel Willemze; J H Frederik Falkenburg; Marieke Griffioen
High-throughput characterization of 10 new minor histocompatibility antigens by whole genome association scanning.

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All Publications

2013: Caroline E Rutten; Cornelis A M van Bergen; S A P van Luxemburg-Heijs; Marieke Griffioen; Constantijn J M Halkes; Erik W A Marijt; Machteld Oudshoorn; J H Frederik Falkenburg
Patient HLA-DP-specific CD4+ T cells from HLA-DPB1-mismatched donor lymphocyte infusion can induce graft-versus-leukemia reactivity in the presence or absence of graft-versus-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2013;19(1):40-8.
2012: Marieke Griffioen; M Willy Honders; Michel Kester; Ellie G A Lurvink; Cornelis A M van Bergen; Els van der Meijden; S A P van Luxemburg-Heijs; J H Frederik Falkenburg
Identification of 4 novel HLA-B*40:01 restricted minor histocompatibility antigens and their potential as targets for graft-versus-leukemia reactivity.
Haematologica 2012;97(8):1196-204.
2010: Cornelis A M van Bergen; Caroline E Rutten; Els van der Meijden; S A P van Luxemburg-Heijs; Ellie G A Lurvink; Jeanine J Houwing-Duistermaat; Michel Kester; Arend Mulder; Roel Willemze; J H Frederik Falkenburg; Marieke Griffioen
High-throughput characterization of 10 new minor histocompatibility antigens by whole genome association scanning.
Cancer research 2010;70(22):9073-83.
2010: Caroline E Rutten; S A P van Luxemburg-Heijs; Edith D van der Meijden; Marieke Griffioen; Machteld Oudshoorn; Roel Willemze; J H Frederik Falkenburg
HLA-DPB1 mismatching results in the generation of a full repertoire of HLA-DPB1-specific CD4+ T cell responses showing immunogenicity of all HLA-DPB1 alleles.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010;16(9):1282-92.
2010: Caroline E Rutten; S A P van Luxemburg-Heijs; Edith D van der Meijden; Marieke Griffioen; Machteld Oudshoorn; Roel Willemze; J H Frederik Falkenburg
Both permissive and nonpermissive HLA-DPB1 mismatches can induce polyclonal HLA-DPB1 specific immune responses in vivo and in vitro.
Blood 2010;115(1):151-3.
2008: C E Rutten; S A P van Luxemburg-Heijs; Marieke Griffioen; Erik W A Marijt; Inge Jedema; Mirjam H M Heemskerk; Eduardus F M Posthuma; Rein Willemze; J H Frederik Falkenburg
HLA-DP as specific target for cellular immunotherapy in HLA class II-expressing B-cell leukemia.
Leukemia 2008;22(7):1387-94.
2008: Marieke Griffioen; Edith D van der Meijden; Elisabeth H Slager; M Willy Honders; Caroline E Rutten; S A P van Luxemburg-Heijs; Peter A von dem Borne; Jon van Rood; Roel Willemze; J H Frederik Falkenburg
Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3837-42.
2007: Jeltje F de Vries; Peter A von dem Borne; S A P van Luxemburg-Heijs; Mirjam H M Heemskerk; Rein Willemze; J H Frederik Falkenburg; Renée M Y Barge
Differential activation of the death receptor pathway in human target cells induced by cytotoxic T lymphocytes showing different kinetics of killing.
Haematologica 2007;92(12):1671-8.
2007: Mels Hoogendoorn; Inge Jedema; Renée M Y Barge; S A P van Luxemburg-Heijs; F Beaumont; Erik W A Marijt; Rein Willemze; J H Frederik Falkenburg
Characterization of graft-versus-leukemia responses in patients treated for advanced chronic lymphocytic leukemia with donor lymphocyte infusions after in vitro T-cell depleted allogeneic stem cell transplantation following reduced-intensity conditioning.
Leukemia 2007;21(12):2569-74.
2007: Cornelis A M van Bergen; Michel Kester; Inge Jedema; Mirjam H M Heemskerk; S A P van Luxemburg-Heijs; Freke M Kloosterboer; W A Erik Marijt; Arnoud de Ru; M Ronald Schaafsma; Rein Willemze; Peter van Veelen; J H Frederik Falkenburg
Multiple myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene.
Blood 2007;109(9):4089-96.
2007: Inge Jedema; Pauline Meij; Esther Steeneveld; Mels Hoogendoorn; Bart A Nijmeijer; Marian van de Meent; S A P van Luxemburg-Heijs; Rein Willemze; J H Frederik Falkenburg
Early detection and rapid isolation of leukemia-reactive donor T cells for adoptive transfer using the IFN-gamma secretion assay.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(2 Pt 1):636-43.
2007: Erik Marijt; Amon R Wafelman; Menno A W G van der Hoorn; Cornelis A M van Bergen; Rian Bongaerts; S A P van Luxemburg-Heijs; Joost van den Muijsenberg; Judith Olde Wolbers; Nicole van der Werff; Rein Willemze; Frederik Falkenburg
Phase I/II feasibility study evaluating the generation of leukemia-reactive cytotoxic T lymphocyte lines for treatment of patients with relapsed leukemia after allogeneic stem cell transplantation.
Haematologica 2007;92(1):72-80.
2006: Freke M Kloosterboer; S A P van Luxemburg-Heijs; Rein Willemze; J H Frederik Falkenburg
Similar potential to become activated and proliferate but differential kinetics and profiles of cytokine production of umbilical cord blood T cells and adult blood naive and memory T cells.
Human immunology 2006;67(11):874-83.
2006: Elisabeth H Slager; M Willy Honders; Els van der Meijden; S A P van Luxemburg-Heijs; Freke M Kloosterboer; Michel Kester; Inge Jedema; W A Erik Marijt; M Ronald Schaafsma; Rein Willemze; J H Frederik Falkenburg
Identification of the angiogenic endothelial-cell growth factor-1/thymidine phosphorylase as a potential target for immunotherapy of cancer.
Blood 2006;107(12):4954-60.
2006: Peter A von dem Borne; S A P van Luxemburg-Heijs; Mirjam H M Heemskerk; Inge Jedema; Arend Mulder; Rein Willemze; J H Frederik Falkenburg
Molecular persistence of chronic myeloid leukemia caused by donor T cells specific for lineage-restricted maturation antigens not recognizing immature progenitor-cells.
Leukemia 2006;20(6):1040-6.
2005: Freke M Kloosterboer; S A P van Luxemburg-Heijs; Ronald A van Soest; H M Esther van Egmond; Rein Willemze; J H Frederik Falkenburg
Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia.
Blood 2005;106(12):3955-7.
2005: Freke M Kloosterboer; S A P van Luxemburg-Heijs; Ronald A van Soest; H M Esther van Egmond; A M Barbui; M P W Strijbosch; Rein Willemze; J H Frederik Falkenburg
Minor histocompatibility antigen-specific T cells with multiple distinct specificities can be isolated by direct cloning of IFNgamma-secreting T cells from patients with relapsed leukemia responding to donor lymphocyte infusion.
Leukemia 2005;19(1):83-90.
2004: Freke M Kloosterboer; S A P van Luxemburg-Heijs; Rein Willemze; J H Frederik Falkenburg
Umbilical cord blood-naive T cells but not adult blood-naive T cells require HLA class II on antigen-presenting cells for allo-immune activation.
Human immunology 2004;65(4):328-39.
2004: Freke M Kloosterboer; S A P van Luxemburg-Heijs; Ronald A van Soest; A M Barbui; H M Esther van Egmond; M P W Strijbosch; Michel Kester; W A Erik Marijt; Els Goulmy; Rein Willemze; J H Frederik Falkenburg
Direct cloning of leukemia-reactive T cells from patients treated with donor lymphocyte infusion shows a relative dominance of hematopoiesis-restricted minor histocompatibility antigen HA-1 and HA-2 specific T cells.
Leukemia 2004;18(4):798-808.
2003: Menno A W G van der Hoorn; S A P van Luxemburg-Heijs; Cornelis A M van Bergen; Rian Bongaerts; Rein Willemze; J H Frederik Falkenburg
The progenitor cell inhibition assay to measure the anti-leukemic reactivity of T cell clones against acute and chronic myeloid leukemia.
Methods (San Diego, Calif.) 2003;31(2):113-9.
2001: Willy A Noort; Jannine Wilpshaar; C D Hertogh; M Rad; Ellie G A Lurvink; S A P van Luxemburg-Heijs; Koos H Zwinderman; R A Verwey; Rein Willemze; J H Frederik Falkenburg
Similar myeloid recovery despite superior overall engraftment in NOD/SCID mice after transplantation of human CD34(+) cells from umbilical cord blood as compared to adult sources.
Bone marrow transplantation 2001;28(2):163-71.
2000: RE Brouwer; Koos H Zwinderman; Hanneke C Kluin-Nelemans; S A P van Luxemburg-Heijs; Rein Willemze; J H Frederik Falkenburg
Expression and induction of costimulatory and adhesion molecules on acute myeloid leukemic cells: implications for adoptive immunotherapy.
Experimental hematology 2000;28(2):161-8.
1999: JJ Melenhorst; S A P van Luxemburg-Heijs; JE Landegent; Rein Willemze; Willem E Fibbe; J H Frederik Falkenburg
Aplastic anaemia in donor cells 14 years after bone-marrow transplant.
Lancet 1999;353(9169):2037-8.
1997: Tuna Mutis; Ellen Schrama; S A P van Luxemburg-Heijs; J H Frederik Falkenburg; Cornelis J M Melief; Els Goulmy
HLA class II restricted T-cell reactivity to a developmentally regulated antigen shared by leukemic cells and CD34+ early progenitor cells.
Blood 1997;90(3):1083-90.
1996: J H Frederik Falkenburg; S A P van Luxemburg-Heijs; F T Lim; H H Kanhai; Rein Willemze
Umbilical cord blood contains normal frequencies of cytotoxic T-lymphocyte precursors (ctlp) and helper T-lymphocyte precursors against noninherited maternal antigens and noninherited paternal antigens.
Annals of hematology 1996;72(4):260-4.
1996: L M Faber; S A P van Luxemburg-Heijs; M Rijnbeek; Rein Willemze; J H Frederik Falkenburg
Minor histocompatibility antigen-specific, leukemia-reactive cytotoxic T cell clones can be generated in vitro without in vivo priming using chronic myeloid leukemia cells as stimulators in the presence of alpha-interferon.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1996;2(1):31-6.
1995: L M Faber; S A P van Luxemburg-Heijs; W F Veenhof; Rein Willemze; J H Frederik Falkenburg
Generation of CD4+ cytotoxic T-lymphocyte clones from a patient with severe graft-versus-host disease after allogeneic bone marrow transplantation: implications for graft-versus-leukemia reactivity.
Blood 1995;86(7):2821-8.
1995: L M Faber; J van der Hoeven; Els Goulmy; A L Hooftman-den Otter; S A P van Luxemburg-Heijs; Rein Willemze; J H Frederik Falkenburg
Recognition of clonogenic leukemic cells, remission bone marrow and HLA-identical donor bone marrow by CD8+ or CD4+ minor histocompatibility antigen-specific cytotoxic T lymphocytes.
The Journal of clinical investigation 1995;96(2):877-83.
1994: D van der Harst; Els Goulmy; J H Frederik Falkenburg; Y M Kooij-Winkelaar; S A P van Luxemburg-Heijs; H M Goselink; Anneke Brand
Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T-cell clones.
Blood 1994;83(4):1060-6.
1993: J H Frederik Falkenburg; L M Faber; M van den Elshout; S A P van Luxemburg-Heijs; A Hooftman-den Otter; W M Smit; P J Voogt; Rein Willemze
Generation of donor-derived antileukemic cytotoxic T-lymphocyte responses for treatment of relapsed leukemia after allogeneic HLA-identical bone marrow transplantation.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(4):305-9.
1993: J H Frederik Falkenburg; S A P van Luxemburg-Heijs; J M Zijlmans; Willem E Fibbe; Johanna C Kluin-Nelemans; H H Kanhai; Rein Willemze
Separation, enrichment, and characterization of human hematopoietic progenitor cells from umbilical cord blood.
Annals of hematology 1993;67(5):231-6.
1992: L M Faber; S A P van Luxemburg-Heijs; Rein Willemze; J H Frederik Falkenburg
Generation of leukemia-reactive cytotoxic T lymphocyte clones from the HLA-identical bone marrow donor of a patient with leukemia.
The Journal of experimental medicine 1992;176(5):1283-9.
1991: D van der Harst; Anneke Brand; S A P van Luxemburg-Heijs; Y M Kooij-Winkelaar; F E Zwaan; Frits Koning
Selective outgrowth of CD45RO+ V gamma 9+/V delta 2+ T-cell receptor gamma/delta T cells early after bone marrow transplantation.
Blood 1991;78(7):1875-81.
1991: J H Frederik Falkenburg; H M Goselink; D van der Harst; S A P van Luxemburg-Heijs; Y M Kooy-Winkelaar; L M Faber; J de Kroon; Anneke Brand; Willem E Fibbe; Rein Willemze
Growth inhibition of clonogenic leukemic precursor cells by minor histocompatibility antigen-specific cytotoxic T lymphocytes.
The Journal of experimental medicine 1991;174(1):27-33.