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Rob van Montfort

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Publications

TOP 3
Sarah R Langdon; Rob L M van Montfort; Isaac M Westwood; Nathan Brown; Julian Blagg
Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors.
Yvette M Newbatt; Jade A Strover; Rosemary Burke; Ian Collins; Faith E Davies; Anthea Hardcastle; P Craig McAndrew; Amin Mirza; Gareth J Morgan; Rob L M van Montfort
Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.
Cornelis Matijssen; Peter Sheldrake; Samerene Siddique; M Cris Silva-Santisteban; Rob L M van Montfort; Isaac M Westwood; Vanessa Choi; Julian Blagg
Benzimidazole inhibitors of the protein kinase CHK2: clarification of the binding mode by flexible side chain docking and protein-ligand crystallography.

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All Publications

2013: Sarah R Langdon; Rob L M van Montfort; Isaac M Westwood; Nathan Brown; Julian Blagg
Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors.
Journal of chemical information and modeling 2013;53(5):1100-12.
2013: Yvette M Newbatt; Jade A Strover; Rosemary Burke; Ian Collins; Faith E Davies; Anthea Hardcastle; P Craig McAndrew; Amin Mirza; Gareth J Morgan; Rob L M van Montfort
Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.
Journal of biomolecular screening 2013;18(3):298-308.
2012: Cornelis Matijssen; Peter Sheldrake; Samerene Siddique; M Cris Silva-Santisteban; Rob L M van Montfort; Isaac M Westwood; Vanessa Choi; Julian Blagg
Benzimidazole inhibitors of the protein kinase CHK2: clarification of the binding mode by flexible side chain docking and protein-ligand crystallography.
Bioorganic & medicinal chemistry 2012;20(22):6630-9.
2011: Caterina Barillari; Julian Blagg; Anna L Duncan; Isaac M Westwood; Rob L M van Montfort
Analysis of water patterns in protein kinase binding sites.
Proteins 2011;79(7):2109-21.
2011: Savade Solanki; Paolo Innocenti; Corine Mas-Droux; Kathy Boxall; Caterina Barillari; Rob L M van Montfort; G Wynne Aherne; Richard Bayliss; Swen Hoelder
Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship.
Journal of medicinal chemistry 2011;54(6):1626-39.
2010: Daniel K Whelligan; Savade Solanki; Dawn Taylor; Douglas W Thomson; Kwai-Ming J Cheung; Kathy Boxall; Corine Mas-Droux; Caterina Barillari; Samantha Burns; Charles G Grummitt; Ian Collins; Rob L M van Montfort; G Wynne Aherne; Richard Bayliss; Swen Hoelder
Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization.
Journal of medicinal chemistry 2010;53(21):7682-98.
2010: Thomas P Matthews; Tatiana McHardy; Suki Klair; Kathy Boxall; Martin Fisher; Michael Cherry; Charlotte E Allen; Glynn J Addison; John Ellard; G Wynne Aherne; Isaac M Westwood; Rob L M van Montfort; Michelle D Garrett; John C Reader; Ian Collins
Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases.
Bioorganic & medicinal chemistry letters 2010;20(14):4045-9.
2010: Paul Workman; Rob L M van Montfort
Unveiling the secrets of the ancestral PI3 kinase Vps34.
Cancer cell 2010;17(5):421-3.
2010: Paul Workman; Paul A Clarke; Florence I Raynaud; Rob L M van Montfort
Drugging the PI3 kinome: from chemical tools to drugs in the clinic.
Cancer research 2010;70(6):2146-57.
2010: Paul Workman; Rob L M van Montfort
PI(3) kinases: revealing the delta lady.
Nature chemical biology 2010;6(2):82-3.
2009: Thomas P Matthews; Suki Klair; Samantha Burns; Kathy Boxall; Michael Cherry; Martin Fisher; Isaac M Westwood; Michael I Walton; Tatiana McHardy; Kwai-Ming J Cheung; Rob L M van Montfort; David Williams; G Wynne Aherne; Michelle D Garrett; John Reader; Ian Collins
Identification of inhibitors of checkpoint kinase 1 through template screening.
Journal of medicinal chemistry 2009;52(15):4810-9.
2009: Rob L M van Montfort; Paul Workman
Structure-based design of molecular cancer therapeutics.
Trends in biotechnology 2009;27(5):315-28.
2009: Isaac Westwood; Donna-Marie Cheary; Joanne E Baxter; Mark W Richards; Rob L M van Montfort; Andrew M Fry; Bayliss Richard
Insights into the conformational variability and regulation of human Nek2 kinase.
Journal of molecular biology 2009;386(2):476-85.
2009: Rob L M van Montfort; Ian Collins
Fragment-based methods in drug discovery: it's the small things that matter.
Current topics in medicinal chemistry 2009;9(18):1676-7.
2006: Nigel Howard; Chris Abell; Wendy Blakemore; Gianni Chessari; Miles Congreve; Steven Howard; Harren Jhoti; Christopher W Murray; Lisa C A Seavers; Rob L M van Montfort
Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.
Journal of medicinal chemistry 2006;49(4):1346-55.
2003: Rob L M van Montfort; Orval A Bateman; Nicolette H Lubsen; Christine Slingsby
Crystal structure of truncated human betaB1-crystallin.
Protein science : a publication of the Protein Society 2003;12(11):2606-12.
2003: Rob L M van Montfort; Miles Congreve; Dominic Tisi; Robin Carr; Harren Jhoti
Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B.
Nature 2003;423(6941):773-7.
2003: Orval A Bateman; Andrew G Purkiss; Rob L M van Montfort; Christine Slingsby; C Graham; Graeme Wistow
Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens.
Biochemistry 2003;42(15):4349-56.
2001: Rob L M van Montfort; Eman Basha; K L Friedrich; Christine Slingsby; Elizabeth Vierling
Crystal structure and assembly of a eukaryotic small heat shock protein.
Nature structural biology 2001;8(12):1025-30.
2001: Rob L M van Montfort; Christine Slingsby; Elizabeth Vierling
Structure and function of the small heat shock protein/alpha-crystallin family of molecular chaperones.
Advances in protein chemistry 2001;59():105-56.