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Emmanuel Van Obberghen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
48
Le Marchand-Brustel, Yannick
30
Ballotti, Robert
28
Tanti, Jean-François
22
Filloux, Chantal
19
Grémeaux, Thierry
15
Cormont, Mireille
14
Tartare-Deckert, Sophie
13
Candito, Mirande
11
Filippa, Nathalie
10
Sawka-Verhelle, Dominique
9
Giorgetti-Peraldi, Sophie
9
Mothe-Satney, Isabelle
9
Murdaca, Joseph
7
Pirola, Luciano
7
Rocchi, Stéphane

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Publications

TOP 3
Lebrun P; Cognard E; Bellon-Paul R; Gontard P; Filloux C; Jehl-Pietri C; Grimaldi P; Samson M; Pénicaud L; Ruberte J; Ferre T; Pujol A; Bosch F; Van Obberghen E
Constitutive expression of suppressor of cytokine signalling-3 in skeletal muscle leads to reduced mobility and overweight in mice.
Cursio Raffaele; Miele Claudia; Filippa Nathalie; Colosetti Pascal; Auberger Patrick; Van Obberghen Emmanuel; Gugenheim Jean
Tyrosine phosphorylation of insulin receptor substrates during ischemia/reperfusion-induced apoptosis in rat liver.
Cassese Angela; Esposito Iolanda; Fiory Francesca; Barbagallo Alessia P M; Paturzo Flora; Mirra Paola; Ulianich Luca; Giacco Ferdinando; Iadicicco Claudia; Lombardi Angela; Oriente Francesco; Van Obberghen Emmanuel; Beguinot Francesco; Formisano Pietro; Miele Claudia
In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.

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All Publications

2009: Lebrun P; Cognard E; Bellon-Paul R; Gontard P; Filloux C; Jehl-Pietri C; Grimaldi P; Samson M; Pénicaud L; Ruberte J; Ferre T; Pujol A; Bosch F; Van Obberghen E
Constitutive expression of suppressor of cytokine signalling-3 in skeletal muscle leads to reduced mobility and overweight in mice.
Diabetologia 2009;52(10):2201-12.
2009: Cursio Raffaele; Miele Claudia; Filippa Nathalie; Colosetti Pascal; Auberger Patrick; Van Obberghen Emmanuel; Gugenheim Jean
Tyrosine phosphorylation of insulin receptor substrates during ischemia/reperfusion-induced apoptosis in rat liver.
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie 2009;394(1):123-31.
2008: Cassese Angela; Esposito Iolanda; Fiory Francesca; Barbagallo Alessia P M; Paturzo Flora; Mirra Paola; Ulianich Luca; Giacco Ferdinando; Iadicicco Claudia; Lombardi Angela; Oriente Francesco; Van Obberghen Emmanuel; Beguinot Francesco; Formisano Pietro; Miele Claudia
In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.
The Journal of biological chemistry 2008;283(52):36088-99.
2008: Schneider Stéphane M; Al-Jaouni Rima; Caruba Céline; Giudicelli Jean; Arab Kamel; Suavet Florence; Ferrari Patricia; Mothe-Satney Isabelle; Van Obberghen Emmanuel; Hébuterne Xavier
Effects of age, malnutrition and refeeding on the expression and secretion of ghrelin.
Clinical nutrition (Edinburgh, Scotland) 2008;27(5):724-31.
2008: El Ouaamari Abdelfattah; Baroukh Nadine; Martens Geert A; Lebrun Patricia; Pipeleers Daniel; van Obberghen Emmanuel
miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells.
Diabetes 2008;57(10):2708-17.
2008: Cursio R; Miele C; Filippa N; Van Obberghen E; Gugenheim J
Liver HIF-1 alpha induction precedes apoptosis following normothermic ischemia-reperfusion in rats.
Transplantation proceedings 2008;40(6):2042-5.
2008: Naïmi Mourad; Van Obberghen Emmanuel
[Nuclear FoxO1 as a bridge between metabolism and mitogenesis]
Médecine sciences : M/S 2008;24(6-7):635-9.
2008: Candito Mirande; Rivet Romain; Herbeth Bernard; Boisson Catherine; Rudigoz René-Charles; Luton Dominique; Journel Hubert; Oury Jean-François; Roux François; Saura Robert; Vernhet Isabelle; Gaucherand Pascal; Muller Françoise; Guidicelli Béatrice; Heckenroth Hélène; Poulain Patrice; Blayau Martine; Francannet Christine; Roszyk Laurence; Brustié Cécile; Staccini Pascal; Gérard Philippe; Fillion-Emery Nathalie; Guéant-Rodriguez Rosa-Maria; Van Obberghen Emmanuel; Guéant Jean-Louis
Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study.
American journal of medical genetics. Part A 2008;146A(9):1128-33.
2008: Demozay Damien; Mas Jean-Christophe; Rocchi Stephane; Van Obberghen Emmanuel
FALDH reverses the deleterious action of oxidative stress induced by lipid peroxidation product 4-hydroxynonenal on insulin signaling in 3T3-L1 adipocytes.
Diabetes 2008;57(5):1216-26.
2008: Ségalen Coralie; Longnus Sarah L; Baetz Delphine; Counillon Laurent; Van Obberghen Emmanuel
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside reduces glucose uptake via the inhibition of Na+/H+ exchanger 1 in isolated rat ventricular cardiomyocytes.
Endocrinology 2008;149(4):1490-8.
2007: Baroukh Nadine; Ravier Magalie A; Loder Merewyn K; Hill Elaine V; Bounacer Ali; Scharfmann Raphaël; Rutter Guy A; Van Obberghen Emmanuel
MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines.
The Journal of biological chemistry 2007;282(27):19575-88.
2007: Hasseine Larbi Kamal; Murdaca Joseph; Suavet Florence; Longnus Sarah; Giorgetti-Peraldi Sophie; Van Obberghen Emmanuel
Hrs is a positive regulator of VEGF and insulin signaling.
Experimental cell research 2007;313(9):1927-42.
2007: Naïmi Mourad; Gautier Nadine; Chaussade Claire; Valverde Angela M; Accili Domenico; Van Obberghen Emmanuel
Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes.
Endocrinology 2007;148(5):2424-34.
2007: Candito Mirande; Naimi Mourad; Boisson Catherine; Rudigoz Jean-Charles; Gaucherand Pascal; Guéant Jean-Louis; Luton Dominique; Van Obberghen Emmanuel
Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect.
Birth defects research. Part A, Clinical and molecular teratology 2007;79(1):62-4.
2006: Bortolotti D; Mothe-Satney I; Ferrari P; Gautier N; Sonke J; Pallé S; Bernard G; Badetti J L; Fredenrich A; Van Obberghen E; Canivet B
Spontaneous hypoglycaemia in the presence of both anti-insulin antibody and anti-insulin receptor antibody.
Diabetes & metabolism 2006;32(6):598-603.
2006: Cursio R; Miele C; Filippa N; Van Obberghen E; Gugenheim J
Alterations in protein tyrosine kinase pathways in rat liver following normothermic ischemia-reperfusion.
Transplantation proceedings 2006;38(10):3362-5.
2006: Chavey Carine; Boucher Jérémie; Monthouël-Kartmann Marie-Noëlle; Sage E Helene; Castan-Laurell Isabelle; Valet Philippe; Tartare-Deckert Sophie; Van Obberghen Emmanuel
Regulation of secreted protein acidic and rich in cysteine during adipose conversion and adipose tissue hyperplasia.
Obesity (Silver Spring, Md.) 2006;14(11):1890-7.
2006: Candito M; Candito E; Chatel M; van Obberghen E; Dunac A
[Homocysteinemia and thrombophilic factors in unexplained decompression sickness]
Revue neurologique 2006;162(8-9):840-4.
2006: Cursio R; Filippa N; Miele C; Van Obberghen E; Gugenheim J
Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury.
The British journal of surgery 2006;93(6):752-61.
2006: Hinault Charlotte; Van Obberghen Emmanuel; Mothe-Satney Isabelle
Role of amino acids in insulin signaling in adipocytes and their potential to decrease insulin resistance of adipose tissue.
The Journal of nutritional biochemistry 2006;17(6):374-8.
2006: Riboulet-Chavey Audrey; Pierron Anne; Durand Isabelle; Murdaca Joseph; Giudicelli Jean; Van Obberghen Emmanuel
Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species.
Diabetes 2006;55(5):1289-99.
2006: Hinault C; Mothe-Satney I; Gautier N; Van Obberghen E
Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes.
Diabetologia 2006;49(5):1017-26.
2006: Candito Mirande; Guéant Jean-Louis; Naimi Mourad; Bongain Alain; Van Obberghen Emmanuel
Antiepileptic drugs: a case report in a pregnancy with a neural tube defect.
Pediatric neurology 2006;34(4):323-4.
2006: Candito M; Chatel M; Candito E; Lapoussiere M; Mengual R; Van Obberghen E; Dunac A
[Thrombophilic factors in divers with undeserved decompression sickness]
Pathologie-biologie 2006;54(3):155-8.
2006: Treins Caroline; Murdaca Joseph; Van Obberghen Emmanuel; Giorgetti-Peraldi Sophie
AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1.
Biochemical and biophysical research communications 2006;342(4):1197-202.
2005: Longnus S L; Ségalen C; Giudicelli J; Sajan M P; Farese R V; Van Obberghen E
Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo.
Diabetologia 2005;48(12):2591-601.
2005: Lebrun Patricia; Montminy Marc R; Van Obberghen Emmanuel
Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase.
The Journal of biological chemistry 2005;280(46):38203-10.
2005: Guéant-Rodriguez Rosa-Maria; Juilliére Yves; Candito Mirande; Adjalla Charles E; Gibelin Pierre; Herbeth Bernard; Van Obberghen Emmanuel; Gueánt Jean-Louis
Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.
Thrombosis and haemostasis 2005;94(3):510-5.
2005: Cursio Raffaele; Filippa Nathalie; Miele Claudia; Colosetti Pascal; Auberger Patrick; Van Obberghen Emmanuel; Gugenheim Jean
Fas ligand expression following normothermic liver ischemia-reperfusion.
The Journal of surgical research 2005;125(1):30-6.
2005: Treins Caroline; Giorgetti-Peraldi Sophie; Murdaca Joseph; Monthouël-Kartmann Marie-Noëlle; Van Obberghen Emmanuel
Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I.
Molecular endocrinology (Baltimore, Md.) 2005;19(5):1304-17.
2004: Emanuelli Brice; Glondu Murielle; Filloux Chantal; Peraldi Pascal; Van Obberghen Emmanuel
The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells.
Diabetes 2004;53 Suppl 3():S97-S103.
2004: Hinault Charlotte; Mothe-Satney Isabelle; Gautier Nadine; Lawrence John C; Van Obberghen Emmanuel
Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(15):1894-6.
2004: Guéant Jean-Louis; Candito Mirande; Andres Emmanuel; Van Obberghen Emmanuel; Nicolas Jean-Pierre
Familial pernicious anaemia with hyperhomocysteinaemia in recurrent early pregnancy loss.
Thrombosis and haemostasis 2004;92(5):1147-9.
2004: Mothe-Satney Isabelle; Gautier Nadine; Hinault Charlotte; Lawrence John C; Van Obberghen Emmanuel
In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids.
The Journal of biological chemistry 2004;279(41):42628-37.
2004: Schneider Stéphane M; Veyres Patricia; Pivot Xavier; Soummer Anne-Marie; Jambou Patrick; Filippi Jérôme; van Obberghen Emmanuel; Hébuterne Xavier
Malnutrition is an independent factor associated with nosocomial infections.
The British journal of nutrition 2004;92(1):105-11.
2004: Murdaca Joseph; Treins Caroline; Monthouël-Kartmann Marie-Noëlle; Pontier-Bres Rodolphe; Kumar Sharad; Van Obberghen Emmanuel; Giorgetti-Peraldi Sophie
Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation.
The Journal of biological chemistry 2004;279(25):26754-61.
2004: Candito M; Houcher B; Boisson C; Abellard J; Demarcq M-J; Guéant J-L; Benhacine K; Gérard P; Van Obberghen E
[Neural tube defects and vitamin B12: a report of three cases]
Annales de biologie clinique 2004;62(2):235-8.
2004: Pirola L; Johnston A M; Van Obberghen E
Modulation of insulin action.
Diabetologia 2004;47(2):170-84.
2004: Demozay Damien; Rocchi Stéphane; Mas Jean-Christophe; Grillo Sophie; Pirola Luciano; Chavey Carine; Van Obberghen Emmanuel
Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin.
The Journal of biological chemistry 2004;279(8):6261-70.
2003: Pirola L; Johnston A M; Van Obberghen E
Modulators of insulin action and their role in insulin resistance.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27 Suppl 3():S61-4.
2003: Chaussade Claire; Pirola Luciano; Bonnafous Stéphanie; Blondeau François; Brenz-Verca Stefano; Tronchère Hélène; Portis Fiorella; Rusconi Sandro; Payrastre Bernard; Laporte Jocelyn; Van Obberghen E
Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport.
Molecular endocrinology (Baltimore, Md.) 2003;17(12):2448-60.
2003: Miele Claudia; Riboulet Audrey; Maitan Maria Alessandra; Oriente Francesco; Romano Chiara; Formisano Pietro; Giudicelli Jean; Beguinot Francesco; Van Obberghen Emmanuel
Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.
The Journal of biological chemistry 2003;278(48):47376-87.
2003: Rezzonico Roger; Cayatte Corinne; Bourget-Ponzio Isabelle; Romey Georges; Belhacene Nathalie; Loubat Agnès; Rocchi Stéphane; Van Obberghen Emmanuel; Girault Jean-Antoine; Rossi Bernard; Schmid-Antomarchi Heidy
Focal adhesion kinase pp125FAK interacts with the large conductance calcium-activated hSlo potassium channel in human osteoblasts: potential role in mechanotransduction.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(10):1863-71.
2003: Candito M; Boisson C; Gaucherand P; Luton D; Oury J F; Burc L; Journel H; Rudigoz R C; Van Obberghen E
[Call for researchers associated with a biological study of neural tube defects: prospective study of the role of homocysteine in neural tube defects in France]
Annales de biologie clinique 2003;61(5):615-6.
2003: Candito Mirande; Magnaldo Sarah; Bayle Jacques; Dor Jean-François; Gillet Yves; Bongain André; Van Obberghen Emmanuel
Clinical B12 deficiency in one case of recurrent spontaneous pregnancy loss.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2003;41(8):1026-7.
2003: Johnston Anne M; Pirola Luciano; Van Obberghen Emmanuel
Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling.
FEBS letters 2003;546(1):32-6.
2003: Pirola Luciano; Bonnafous Stephanie; Johnston Anne M; Chaussade Claire; Portis Fiorella; Van Obberghen Emmanuel
Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells.
The Journal of biological chemistry 2003;278(18):15641-51.
2003: Chavey Carine; Mari Bernard; Monthouel Marie-Noëlle; Bonnafous Stéphanie; Anglard Patrick; Van Obberghen Emmanuel; Tartare-Deckert Sophie
Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation.
The Journal of biological chemistry 2003;278(14):11888-96.
2002: Benmerabet S; Fredenrich A; Robillon J F; Canivet B; Candito M; Van Obberghen E
[Clinical relevance of homocysteine monitoring in the diabetic patient]
Diabetes & metabolism 2002;28(6 Pt 1):510-5.
2002: Hiéronimus Sylvie; Bastard Stéphanie; Gillet Jean-Yves; Giudicelli Jean; Brucker-Davis Françoise; Berthier Frédéric; Van Obberghen Emmanuel; Fénichel Patrick
Significance of cord-blood leptin in newborns of diabetic mothers.
Diabetes care 2002;25(10):1886-7.
2002: Treins Caroline; Giorgetti-Peraldi Sophie; Murdaca Joseph; Semenza Gregg L; Van Obberghen Emmanuel
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway.
The Journal of biological chemistry 2002;277(31):27975-81.
2002: Almind Katrine; Delahaye Laurent; Hansen Torben; Van Obberghen Emmanuel; Pedersen Oluf; Kahn C Ronald
Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2124-8.
2001: Emanuelli B; Peraldi P; Filloux C; Chavey C; Freidinger K; Hilton D J; Hotamisligil G S; Van Obberghen E
SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice.
The Journal of biological chemistry 2001;276(51):47944-9.
2001: Van Obberghen E; Baron V; Delahaye L; Emanuelli B; Filippa N; Giorgetti-Peraldi S; Lebrun P; Mothe-Satney I; Peraldi P; Rocchi S; Sawka-Verhelle D; Tartare-Deckert S; Giudicelli J
Surfing the insulin signaling web.
European journal of clinical investigation 2001;31(11):966-77.
2001: Treins C; Giorgetti-Peraldi S; Murdaca J; Van Obberghen E
Regulation of vascular endothelial growth factor expression by advanced glycation end products.
The Journal of biological chemistry 2001;276(47):43836-41.
2001: Oriente F; Formisano P; Miele C; Fiory F; Maitan M A; Vigliotta G; Trencia A; Santopietro S; Caruso M; Van Obberghen E; Beguinot F
Insulin receptor substrate-2 phosphorylation is necessary for protein kinase C zeta activation by insulin in L6hIR cells.
The Journal of biological chemistry 2001;276(40):37109-19.
2001: Giorgetti-Peraldi S; Murdaca J; Mas J C; Van Obberghen E
The adapter protein, Grb10, is a positive regulator of vascular endothelial growth factor signaling.
Oncogene 2001;20(30):3959-68.
2001: Peraldi P; Filloux C; Emanuelli B; Hilton D J; Van Obberghen E
Insulin induces suppressor of cytokine signaling-3 tyrosine phosphorylation through janus-activated kinase.
The Journal of biological chemistry 2001;276(27):24614-20.
2001: Tartare-Deckert S; Chavey C; Monthouel M N; Gautier N; Van Obberghen E
The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity.
The Journal of biological chemistry 2001;276(25):22231-7.
2001: Pirola L; Zvelebil M J; Bulgarelli-Leva G; Van Obberghen E; Waterfield M D; Wymann M P
Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.
The Journal of biological chemistry 2001;276(24):21544-54.
2001: Tartare-Deckert S; Monthouel M N; Charvet C; Foucault I; Van Obberghen E; Bernard A; Altman A; Deckert M
Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte.
The Journal of biological chemistry 2001;276(24):20849-57.
2000: Rocchi S; Gaillard I; van Obberghen E; Chambaz E M; Vilgrain I
Adrenocorticotrophic hormone stimulates phosphotyrosine phosphatase SHP2 in bovine adrenocortical cells: phosphorylation and activation by cAMP-dependent protein kinase.
The Biochemical journal 2000;352 Pt 2():483-90.
2000: Lebrun P; Baron V; Hauck C R; Schlaepfer D D; Van Obberghen E
Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression.
The Journal of biological chemistry 2000;275(49):38371-7.
2000: Filippa N; Sable C L; Hemmings B A; Van Obberghen E
Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation.
Molecular and cellular biology 2000;20(15):5712-21.
2000: Miele C; Rochford J J; Filippa N; Giorgetti-Peraldi S; Van Obberghen E
Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways.
The Journal of biological chemistry 2000;275(28):21695-702.
2000: Sawka-Verhelle D; Tartare-Deckert S; Decaux J F; Girard J; Van Obberghen E
Stat 5B, activated by insulin in a Jak-independent fashion, plays a role in glucokinase gene transcription.
Endocrinology 2000;141(6):1977-88.
2000: Emanuelli B; Peraldi P; Filloux C; Sawka-Verhelle D; Hilton D; Van Obberghen E
SOCS-3 is an insulin-induced negative regulator of insulin signaling.
The Journal of biological chemistry 2000;275(21):15985-91.
2000: Gual P; Giordano S; Williams T A; Rocchi S; Van Obberghen E; Comoglio P M
Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.
Oncogene 2000;19(12):1509-18.
2000: Delahaye L; Rocchi S; Van Obberghen E
Potential involvement of FRS2 in insulin signaling.
Endocrinology 2000;141(2):621-8.
1999: Almind K; Frederiksen S K; Bernal D; Hansen T; Ambye L; Urhammer S; Ekstrøm C T; Berglund L; Reneland R; Lithell H; White M F; Van Obberghen E; Pedersen O
Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.
Diabetologia 1999;42(10):1244-9.
1999: Filippa N; Sable C L; Filloux C; Hemmings B; Van Obberghen E
Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase.
Molecular and cellular biology 1999;19(7):4989-5000.
1999: Candito M; Bedoucha P; Gibelin P; Jambou D; de Franchis R; Sadoul J L; Chatel M; Van Obberghen E
Fasting, postprandial, and post-methionine-load homocysteinaemia and methylenetetrahydrofolate reductase polymorphism in vascular disease.
Journal of inherited metabolic disease 1999;22(5):588-92.
1999: Miele C; Caruso M; Calleja V; Auricchio R; Oriente F; Formisano P; Condorelli G; Cafieri A; Sawka-Verhelle D; Van Obberghen E; Beguinot F
Differential role of insulin receptor substrate (IRS)-1 and IRS-2 in L6 skeletal muscle cells expressing the Arg1152 --> Gln insulin receptor.
The Journal of biological chemistry 1999;274(5):3094-102.
1998: Delahaye L; Mothe-Satney I; Myers M G; White M F; Van Obberghen E
Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites.
Endocrinology 1998;139(12):4911-9.
1998: Lebrun P; Mothe-Satney I; Delahaye L; Van Obberghen E; Baron V
Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src).
The Journal of biological chemistry 1998;273(48):32244-53.
1998: Sable C L; Filippa N; Filloux C; Hemmings B A; Van Obberghen E
Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.
The Journal of biological chemistry 1998;273(45):29600-6.
1998: Kasus-Jacobi A; Perdereau D; Auzan C; Clauser E; Van Obberghen E; Mauvais-Jarvis F; Girard J; Burnol A F
Identification of the rat adapter Grb14 as an inhibitor of insulin actions.
The Journal of biological chemistry 1998;273(40):26026-35.
1998: Rocchi S; Tartare-Deckert S; Murdaca J; Holgado-Madruga M; Wong A J; Van Obberghen E
Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules.
Molecular endocrinology (Baltimore, Md.) 1998;12(7):914-23.
1998: Baron V; Alengrin F; Van Obberghen E
Dynamin associates with Src-Homology Collagen (Shc) and becomes tyrosine phosphorylated in response to insulin.
Endocrinology 1998;139(6):3034-7.
1998: Némoz-Gaillard E; Cordier-Bussat M; Filloux C; Cuber J C; Van Obberghen E; Chayvialle J A; Abello J
Bombesin stimulates cholecystokinin secretion through mitogen-activated protein-kinase-dependent and -independent mechanisms in the enteroendocrine STC-1 cell line.
The Biochemical journal 1998;331 ( Pt 1)():129-35.
1998: Baron V; Calléja V; Ferrari P; Alengrin F; Van Obberghen E
p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors.
The Journal of biological chemistry 1998;273(12):7162-8.
1998: Gual P; Baron V; Lequoy V; Van Obberghen E
Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor.
Endocrinology 1998;139(3):884-93.
1997: Sawka-Verhelle D; Filloux C; Tartare-Deckert S; Mothe I; Van Obberghen E
Identification of Stat 5B as a substrate of the insulin receptor.
European journal of biochemistry / FEBS 1997;250(2):411-7.
1997: Mothe I; Delahaye L; Filloux C; Pons S; White M F; Van Obberghen E
Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins.
Molecular endocrinology (Baltimore, Md.) 1997;11(13):1911-23.
1997: Gibelin P; Candito M; Houenassi M; Van Obberghen E; Morand P; Baudouy M
[Blood levels of homocysteine in patients under 55 years of age with acute coronary insufficiency]
Presse médicale (Paris, France : 1983) 1997;26(30):1425-8.
1997: Candito M; Bedoucha P; Jambou D; Appert-Flory A; Fisher F; Parrot-Roulaud F; Bayle J; Van Obberghen E; Chatel M
[Cerebral vascular complication of hyperhomocysteinemia. Controlling thromboembolic complications with folates]
Presse médicale (Paris, France : 1983) 1997;26(27):1289-91.
1997: Ricort J M; Tanti J F; Van Obberghen E; Le Marchand-Brustel Y
Cross-talk between the platelet-derived growth factor and the insulin signaling pathways in 3T3-L1 adipocytes.
The Journal of biological chemistry 1997;272(32):19814-8.
1997: Kasus-Jacobi A; Perdereau D; Tartare-Deckert S; Van Obberghen E; Girard J; Burnol A F
Evidence for a direct interaction between insulin receptor substrate-1 and Shc.
The Journal of biological chemistry 1997;272(27):17166-70.
1997: Sable C L; Filippa N; Hemmings B; Van Obberghen E
cAMP stimulates protein kinase B in a Wortmannin-insensitive manner.
FEBS letters 1997;409(2):253-7.
1997: Sawka-Verhelle D; Baron V; Mothe I; Filloux C; White M F; Van Obberghen E
Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor.
The Journal of biological chemistry 1997;272(26):16414-20.
1997: Tanti J F; Grillo S; Grémeaux T; Coffer P J; Van Obberghen E; Le Marchand-Brustel Y
Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes.
Endocrinology 1997;138(5):2005-10.
1997: Calleja V; Ruiz Enríquez P; Filloux C; Peraldi P; Baron V; Van Obberghen E
The effect of cyclic adenosine monophosphate on the mitogen-activated protein kinase pathway depends on both the cell type and the type of tyrosine kinase-receptor.
Endocrinology 1997;138(3):1111-20.
1997: Henry C; Tanti J F; Grémeaux T; Morin C; Van Obberghen E; Comet M; Le Marchand-Brustel Y
Characterization of 6-deoxy-6-iodo-D-glucose: a potential new tool to assess glucose transport.
Nuclear medicine and biology 1997;24(1):99-104.
1996: Cormont M; Bortoluzzi M N; Gautier N; Mari M; van Obberghen E; Le Marchand-Brustel Y
Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes.
Molecular and cellular biology 1996;16(12):6879-86.
1996: Rocchi S; Tartare-Deckert S; Sawka-Verhelle D; Gamha A; van Obberghen E
Interaction of SH2-containing protein tyrosine phosphatase 2 with the insulin receptor and the insulin-like growth factor-I receptor: studies of the domains involved using the yeast two-hybrid system.
Endocrinology 1996;137(11):4944-52.
1996: Baron V; Gual P; Alengrin F; Van Obberghen E
Role of the insulin receptor C-terminal acidic domain in the modulation of the receptor kinase by polybasic effectors.
European journal of biochemistry / FEBS 1996;241(1):186-92.
1996: Tanti J F; Grémeaux T; Grillo S; Calleja V; Klippel A; Williams L T; Van Obberghen E; Le Marchand-Brustel Y
Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes.
The Journal of biological chemistry 1996;271(41):25227-32.
1996: Bortoluzzi M N; Cormont M; Gautier N; Van Obberghen E; Le Marchand-Brustel Y
GTPase activating protein activity for Rab4 is enriched in the plasma membrane of 3T3-L1 adipocytes. Possible involvement in the regulation of Rab4 subcellular localization.
Diabetologia 1996;39(8):899-906.
1996: Gual P; Baron V; Alengrin F; Mothe I; Van Obberghen E
Insulin receptor-induced phosphorylation of cellular and synthetic substrates is regulated by the receptor beta-subunit C-terminus.
Endocrinology 1996;137(8):3416-23.
1996: Cormont M; Van Obberghen E; Zerial M; Le Marchand-Brustel Y
Insulin induces a change in Rab5 subcellular localization in adipocytes independently of phosphatidylinositol 3-kinase activation.
Endocrinology 1996;137(8):3408-15.
1996: Ricort J M; Tanti J F; Van Obberghen E; Le Marchand-Brustel Y
Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport.
European journal of biochemistry / FEBS 1996;239(1):17-22.
1996: Jullien D; Heydrick S J; Gautier N; Van Obberghen E; Le Marchand-Brustel Y
Effect of IGF-I on phosphatidylinositol 3-kinase in soleus muscle of lean and insulin-resistant obese mice.
Diabetes 1996;45(7):869-75.
1996: Sawka-Verhelle D; Tartare-Deckert S; White M F; Van Obberghen E
Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786.
The Journal of biological chemistry 1996;271(11):5980-3.
1996: Tartare-Deckert S; Murdaca J; Sawka-Verhelle D; Holt K H; Pessin J E; Van Obberghen E
Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF- I) receptor: comparative study using the yeast two-hybrid system.
Endocrinology 1996;137(3):1019-24.
1995: Giorgetti-Peraldi S; Peyrade F; Baron V; Van Obberghen E
Involvement of Janus kinases in the insulin signaling pathway.
European journal of biochemistry / FEBS 1995;234(2):656-60.
1995: Gual P; Baron V; Alengrin F; Van Obberghen E
A conformational change in the beta-subunit of the insulin-like growth factor I receptor identified by antipeptide antibodies.
Endocrinology 1995;136(12):5298-304.
1995: Rocchi S; Tartare-Deckert S; Mothe I; Van Obberghen E
Identification by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and phosphatidylinositol 3-kinase.
Endocrinology 1995;136(12):5291-7.
1995: Ricort J M; Tanti J F; Van Obberghen E; Le Marchand-Brustel Y
Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes.
Diabetologia 1995;38(10):1148-56.
1995: Tartare-Deckert S; Sawka-Verhelle D; Murdaca J; Van Obberghen E
Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system.
The Journal of biological chemistry 1995;270(40):23456-60.
1995: Le Marchand-Brustel Y; Heydrick S J; Jullien D; Gautier N; Van Obberghen E
Effected of insulin and insulin-like growth factor-I on glucose transport and its transporters in soleus muscle of lean and obese mice.
Metabolism: clinical and experimental 1995;44(10 Suppl 4):18-23.
1995: Le Marchand-Brustel Y; Gautier N; Cormont M; Van Obberghen E
Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells.
Endocrinology 1995;136(8):3564-70.
1995: Baron V; Kaliman P; Alengrin F; Van Obberghen E
Interaction of the C-terminal acidic domain of the insulin receptor with histone modulates the receptor kinase activity.
European journal of biochemistry / FEBS 1995;229(1):27-34.
1995: Heydrick S J; Gautier N; Olichon-Berthe C; Van Obberghen E; Le Marchand-Brustel Y
Early alteration of insulin stimulation of PI 3-kinase in muscle and adipocyte from gold thioglucose obese mice.
The American journal of physiology 1995;268(4 Pt 1):E604-12.
1995: Frödin M; Sekine N; Roche E; Filloux C; Prentki M; Wollheim C B; Van Obberghen E
Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.
The Journal of biological chemistry 1995;270(14):7882-9.
1995: Mothe I; Tartare S; Kowalski-Chauvel A; Kaliman P; Van Obberghen E; Ballotti R
Tyrosine kinase activity of a chimeric insulin-like-growth-factor-1 receptor containing the insulin receptor C-terminal domain. Comparison with the tyrosine kinase activities of the insulin and insulin-like-growth-factor-1 receptors using a cell-free system.
European journal of biochemistry / FEBS 1995;228(3):842-8.
1995: Peraldi P; Frödin M; Barnier J V; Calleja V; Scimeca J C; Filloux C; Calothy G; Van Obberghen E
Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP.
FEBS letters 1995;357(3):290-6.
1995: Hauguel-de-Mouzon S; Mrejen C; Alengrin F; Van Obberghen E
Glucose-induced stimulation of human insulin-receptor mRNA and tyrosine kinase activity in cultured cells.
The Biochemical journal 1995;305 ( Pt 1)():119-24.
1995: Baron V; Van Obberghen E
[Mechanism of insulin action]
Comptes rendus des séances de la Société de biologie et de ses filiales 1995;189(1):25-41.
1995: Le Marchand-Brustel Y; Heydrick S; Gautier N; Olichon-Berthe C; Van Obberghen E
[Development of insulin resistance in muscle and adipose tissue during obesity in the mouse. Role of phosphatidylinositol 3-kinase]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1995;():121-8.
1995: Baron V; Van Obberghen E
[Signal transduction by the insulin receptor]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1995;():1-13.
1994: Tanti J F; Grémeaux T; Van Obberghen E; Le Marchand-Brustel Y
Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase.
The Biochemical journal 1994;304 ( Pt 1)():17-21.
1994: Van Obberghen E
Signalling through the insulin receptor and the insulin-like growth factor-I receptor.
Diabetologia 1994;37 Suppl 2():S125-34.
1994: Giorgetti S; Pelicci P G; Pelicci G; Van Obberghen E
Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor.
European journal of biochemistry / FEBS 1994;223(1):195-202.
1994: Ricort J M; Tanti J F; Cormont M; Van Obberghen E; Le Marchand-Brustel Y
Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states.
FEBS letters 1994;347(1):42-4.
1994: Peraldi P; Zhao Z; Filloux C; Fischer E H; Van Obberghen E
Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):5002-6.
1994: Tartare S; Mothe I; Kowalski-Chauvel A; Breittmayer J P; Ballotti R; Van Obberghen E
Signal transduction by a chimeric insulin-like growth factor-1 (IGF-1) receptor having the carboxyl-terminal domain of the insulin receptor.
The Journal of biological chemistry 1994;269(15):11449-55.
1994: Cormont M; Tanti J F; Van Obberghen E; Le Marchand-Brustel Y
Expression of guanine-nucleotide-binding proteins in lean and obese insulin-resistant mice.
Molecular and cellular endocrinology 1994;99(2):169-76.
1994: Tanti J F; Grémeaux T; van Obberghen E; Le Marchand-Brustel Y
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
The Journal of biological chemistry 1994;269(8):6051-7.
1994: Cormont M; Tanti J F; Zahraoui A; Van Obberghen E; Le Marchand-Brustel Y
Rab4 is phosphorylated by the insulin-activated extracellular-signal-regulated kinase ERK1.
European journal of biochemistry / FEBS 1994;219(3):1081-5.
1994: Frödin M; Peraldi P; Van Obberghen E
Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.
The Journal of biological chemistry 1994;269(8):6207-14.
1994: Olichon-Berthe C; Hauguel-De Mouzon S; Péraldi P; Van Obberghen E; Le Marchand-Brustel Y
Insulin receptor dephosphorylation by phosphotyrosine phosphatases obtained from insulin-resistant obese mice.
Diabetologia 1994;37(1):56-60.
1993: Peraldi P; Van Obberghen E
Insulin and tumor-promoting agent regulate an inhibitor of the 44-kDa mitogen-activated protein kinase/extracellular signal-regulated protein kinase 1 in fibroblasts.
European journal of biochemistry / FEBS 1993;218(3):815-21.
1993: Cormont M; Tanti J F; Zahraoui A; Van Obberghen E; Tavitian A; Le Marchand-Brustel Y
Insulin and okadaic acid induce Rab4 redistribution in adipocytes.
The Journal of biological chemistry 1993;268(26):19491-7.
1993: Kaliman P; Baron V; Alengrin F; Takata Y; Webster N J; Olefsky J M; Van Obberghen E
The insulin receptor C-terminus is involved in regulation of the receptor kinase activity.
Biochemistry 1993;32(37):9539-44.
1993: Mothe I; Ballotti R; Tartare S; Kowalski-Chauvel A; Van Obberghen E
Cross talk among tyrosine kinase receptors in PC12 cells: desensitization of mitogenic epidermal growth factor receptors by the neurotrophic factors, nerve growth factor and basic fibroblast growth factor.
Molecular biology of the cell 1993;4(7):737-46.
1993: Jullien D; Tanti J F; Heydrick S J; Gautier N; Grémeaux T; Van Obberghen E; Le Marchand-Brustel Y
Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity.
The Journal of biological chemistry 1993;268(20):15246-51.
1993: Tanti J F; Grémeaux T; Cormont M; Van Obberghen E; Le Marchand-Brustel Y
Okadaic acid stimulates IGF-II receptor translocation and inhibits insulin action in adipocytes.
The American journal of physiology 1993;264(6 Pt 1):E868-73.
1993: Peraldi P; Scimeca J C; Filloux C; Van Obberghen E
Regulation of extracellular signal-regulated protein kinase-1 (ERK-1; pp44/mitogen-activated protein kinase) by epidermal growth factor and nerve growth factor in PC12 cells: implication of ERK1 inhibitory activities.
Endocrinology 1993;132(6):2578-85.
1993: Lebrun C; Baron V; Kaliman P; Gautier N; Dolais-Kitabgi J; Taylor S; Accili D; Van Obberghen E
Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the mutant insulin receptor valine 382.
The Journal of biological chemistry 1993;268(15):11272-7.
1993: Nguyen T T; Scimeca J C; Filloux C; Peraldi P; Carpentier J L; Van Obberghen E
Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor.
The Journal of biological chemistry 1993;268(13):9803-10.
1993: Olichon-Berthe C; Gautier N; Van Obberghen E; Le Marchand-Brustel Y
Expression of the glucose transporter GLUT4 in the muscular dystrophic mdx mouse.
The Biochemical journal 1993;291 ( Pt 1)():257-61.
1993: Heydrick S J; Jullien D; Gautier N; Tanti J F; Giorgetti S; Van Obberghen E; Le Marchand-Brustel Y
Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.
The Journal of clinical investigation 1993;91(4):1358-66.
1993: Giorgetti S; Ballotti R; Kowalski-Chauvel A; Tartare S; Van Obberghen E
The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro.
The Journal of biological chemistry 1993;268(10):7358-64.
1993: Hauguel-de Mouzon S; Peraldi P; Alengrin F; Van Obberghen E
Alteration of phosphotyrosine phosphatase activity in tissues from diabetic and pregnant rats.
Endocrinology 1993;132(1):67-74.
1993: Van Obberghen E; Baron V; Scimeca J C; Kaliman P
Insulin receptor: receptor activation and signal transduction.
Advances in second messenger and phosphoprotein research 1993;28():195-201.
1993: Baron V; Ballotti R; Van Obberghen E
[Insulin receptors: activators and signalling]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1993;():1-10.
1992: Tanti J F; Gautier N; Cormont M; Baron V; Van Obberghen E; Le Marchand-Brustel Y
Potential involvement of the carboxy-terminus of the Glut 1 transporter in glucose transport.
Endocrinology 1992;131(5):2319-24.
1992: Baron V; Kaliman P; Gautier N; Van Obberghen E
The insulin receptor activation process involves localized conformational changes.
The Journal of biological chemistry 1992;267(32):23290-4.
1992: Olichon-Berthe C; Van Obberghen E; Le Marchand-Brustel Y
Effect of cold acclimation on the expression of glucose transporter Glut 4.
Molecular and cellular endocrinology 1992;89(1-2):11-8.
1992: Ballotti R; Tartare S; Van Obberghen E
[The insulin receptor: mechanism of activation and message transmission]
Pathologie-biologie 1992;40(8):754-62.
1992: Scimeca J C; Nguyen T T; Filloux C; Van Obberghen E
Nerve growth factor-induced phosphorylation cascade in PC12 pheochromocytoma cells. Association of S6 kinase II with the microtubule-associated protein kinase, ERK1.
The Journal of biological chemistry 1992;267(24):17369-74.
1992: Peraldi P; Hauguel-de Mouzon S; Alengrin F; Van Obberghen E
Dephosphorylation of human insulin-like growth factor I (IGF-I) receptors by membrane-associated tyrosine phosphatases.
The Biochemical journal 1992;285 ( Pt 1)():71-8.
1992: Giorgetti S; Ballotti R; Kowalski-Chauvel A; Cormont M; Van Obberghen E
Insulin stimulates phosphatidylinositol-3-kinase activity in rat adipocytes.
European journal of biochemistry / FEBS 1992;207(2):599-606.
1992: Cormont M; Gremeaux T; Tanti J F; Van Obberghen E; Le Marchand-Brustel Y
Polymyxin B inhibits insulin-induced glucose transporter and IGF II receptor translocation in isolated adipocytes.
European journal of biochemistry / FEBS 1992;207(1):185-93.
1992: Kaliman P; Baron V; Gautier N; Van Obberghen E
Antipeptide antibody to the insulin-like growth factor-I receptor sequence 1232-1246 inhibits the receptor kinase activity.
The Journal of biological chemistry 1992;267(15):10645-51.
1992: Scimeca J C; Ballotti R; Filloux C; Van Obberghen E
Insulin and orthovanadate stimulate multiple phosphotyrosine-containing serine kinases.
Molecular and cellular biochemistry 1992;109(2):139-47.
1992: Tartare S; Ballotti R; Lammers R; Filloux C; Chauvel A; Schlessinger J; Ullrich A; Van Obberghen E
Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity.
The Journal of cell biology 1992;116(3):627-33.
1992: Ballotti R; Baron V; Gautier N; Hainaut P; Scimeca J C; Dolais-Kitabgi J; Lammers R; Schlessinger J; Ullrich A; Van Obberghen E
Activation and regulation of the insulin receptor kinase.
Diabète & métabolisme 1992;18(1 Pt 2):98-103.
1991: Cormont M; Tanti J F; Grémeaux T; Van Obberghen E; Le Marchand-Brustel Y
Subcellular distribution of low molecular weight guanosine triphosphate-binding proteins in adipocytes: colocalization with the glucose transporter Glut 4.
Endocrinology 1991;129(6):3343-50.
1991: Tartare S; Ballotti R; Van Obberghen E
Interaction between heterologous receptor tyrosine kinases. Hormone-stimulated insulin receptors activate unoccupied IGF-I receptors.
FEBS letters 1991;295(1-3):219-22.
1991: Ballotti R; Tartare S; Chauvel A; Scimeca J C; Alengrin F; Filloux C; Van Obberghen E
Phenylarsine oxide stimulates a cytosolic tyrosine kinase activity and glucose transport in mouse fibroblasts.
Experimental cell research 1991;197(2):300-6.
1991: Cormont M; Le Marchand-Brustel Y; Van Obberghen E; Spiegel A M; Sharp G W
Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor.
Diabetes 1991;40(9):1170-6.
1991: Scimeca J C; Ballotti R; Nguyen T T; Filloux C; Van Obberghen E
Tyrosine and threonine phosphorylation of an immunoaffinity-purified 44-kDa MAP kinase.
Biochemistry 1991;30(38):9313-9.
1991: Baron V; Gautier N; Kaliman P; Dolais-Kitabgi J; Van Obberghen E
The carboxyl-terminal domain of the insulin receptor: its potential role in growth-promoting effects.
Biochemistry 1991;30(38):9365-70.
1991: Hainaut P; Giorgetti S; Kowalski A; Ballotti R; Van Obberghen E
Antibodies to phosphotyrosine injected in Xenopus laevis oocytes modulate maturation induced by insulin/IGF-I.
Experimental cell research 1991;195(1):129-36.
1991: Tartare S; Ballotti R; Lammers R; Alengrin F; Dull T; Schlessinger J; Ullrich A; Van Obberghen E
Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors.
The Journal of biological chemistry 1991;266(15):9900-6.
1991: Hainaut P; Giorgetti S; Kowalski A; Van Obberghen E
Insulin-like effects of vanadate on glucose uptake and on maturation in Xenopus laevis oocytes.
Cell regulation 1991;2(4):317-27.
1991: Hainaut P; Kowalski A; Le Marchand-Brustel Y; Giorgetti S; Gautier N; Van Obberghen E
Effects of insulin, insulin-like growth factor-I (IGF-I) and progesterone on glucose and amino acid uptake in Xenopus laevis oocytes.
Molecular and cellular endocrinology 1991;75(2):133-9.
1991: Baron-Van Evercooren A; Olichon-Berthe C; Kowalski A; Visciano G; Van Obberghen E
Expression of IGF-I and insulin receptor genes in the rat central nervous system: a developmental, regional, and cellular analysis.
Journal of neuroscience research 1991;28(2):244-53.
1991: Hainaut P; Kowalski A; Giorgetti S; Baron V; Van Obberghen E
Insulin and insulin-like-growth-factor-I (IGF-I) receptors in Xenopus laevis oocytes. Comparison with insulin receptors from liver and muscle.
The Biochemical journal 1991;273 ( Pt 3)():673-8.
1991: Tanti J F; Grémeaux T; Van Obberghen E; Le Marchand-Brustel Y
Effects of okadaic acid, an inhibitor of protein phosphatases-1 and -2A, on glucose transport and metabolism in skeletal muscle.
The Journal of biological chemistry 1991;266(4):2099-103.
1990: Le Marchand-Brustel Y; Olichon-Berthe C; Grémeaux T; Tanti J F; Rochet N; Van Obberghen E
Glucose transporter in insulin sensitive tissues of lean and obese mice. Effect of the thermogenic agent BRL 26830A.
Endocrinology 1990;127(6):2687-95.
1990: Rochet N; Sadoul J L; Ferrua B; Kubar J; Tanti J F; Bougnères P; Vialettes B; Van Obberghen E; Le Marchand-Brustel Y; Freychet P
Autoantibodies to the insulin receptor are infrequent findings in type 1 (insulin-dependent) diabetes mellitus of recent onset.
Diabetologia 1990;33(7):411-6.
1990: Baron V; Gautier N; Komoriya A; Hainaut P; Scimeca J C; Mervic M; Lavielle S; Dolais-Kitabgi J; Van Obberghen E
Insulin binding to its receptor induces a conformational change in the receptor C-terminus.
Biochemistry 1990;29(19):4634-41.
1990: Le Marchand-Brustel Y; Rochet N; Grémeaux T; Marot I; Van Obberghen E
Effect of an alpha-glycosidase inhibitor on experimentally-induced obesity in mice.
Diabetologia 1990;33(1):24-30.
1989: Le Marchand-Brustel Y; Ballotti R; Grémeaux T; Tanti J F; Brandenburg D; Van Obberghen E
Functional labeling of insulin receptor subunits in live cells. Alpha 2 beta 2 species is the major autophosphorylated form.
The Journal of biological chemistry 1989;264(35):21316-21.
1989: Ballotti R; Lammers R; Scimeca J C; Dull T; Schlessinger J; Ullrich A; Van Obberghen E
Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae.
The EMBO journal 1989;8(11):3303-9.
1989: Baron V; Gautier N; Rochet N; Ballotti R; Rossi B; Saint-Pierre S; Van Obberghen E; Dolais-Kitabgi J
Antibodies to insulin receptor tyrosine kinase stimulate its activity towards exogenous substrates without inducing receptor autophosphorylation.
The Biochemical journal 1989;260(3):749-56.
1989: Sharp G W; Le Marchand-Brustel Y; Yada T; Russo L L; Bliss C R; Cormont M; Monge L; Van Obberghen E
Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase.
The Journal of biological chemistry 1989;264(13):7302-9.
1989: Rochet N; Blanche S; Carel J C; Fischer A; Deist F L; Griscelli C; Van Obberghen E; Le Marchand-Brustel Y
Hypoglycaemia induced by antibodies to insulin receptor following a bone marrow transplantation in an immunodeficient child.
Diabetologia 1989;32(3):167-72.
1989: Kubar J; Van Obberghen E
Oligomeric states of the insulin receptor: binding and autophosphorylation properties.
Biochemistry 1989;28(3):1086-93.
1989: Tanti J F; Rochet N; Grémeaux T; Van Obberghen E; Le Marchand-Brustel Y
Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice.
The Biochemical journal 1989;258(1):141-6.
1989: Le Marchand-Brustel Y; Tanti J F; Rochet N; Grémeaux T; Van Obberghen E
[Mechanisms of insulin resistance]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1989;():175-84.
1989: Ballotti R; Le Marchand-Brustel Y; Gammeltoft S; Van Obberghen E
Insulin receptor: tyrosine kinase activity and insulin action.
Reproduction, nutrition, development 1989;29(6):653-61.
1989: Van Obberghen E; Scimeca J C; Ballotti R
[Insulin receptor and action mechanism of the hormone]
Annales d'endocrinologie 1989;50(5):434-9.
1989: Ballotti R; Scimeca J C; Kowalski A; Van Obberghen E
Antiphosphotyrosine antibodies modulate insulin receptor kinase activity and insulin action.
Cellular signalling 1989;1(2):195-204.
1988: Rochet N; Tanti J F; Grémeaux T; Van Obberghen E; Le Marchand-Brustel Y
Effect of a thermogenic agent, BRL 26830A, on insulin receptors in obese mice.
The American journal of physiology 1988;255(2 Pt 1):E101-9.
1988: Gammeltoft S; Ballotti R; Nielsen F C; Kowalski A; Van Obberghen E
Receptors for insulin-like growth factors in the central nervous system: structure and function.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1988;20(7):436-42.
1988: Gammeltoft S; Ballotti R; Kowalski A; Westermark B; Van Obberghen E
Expression of two types of receptor for insulin-like growth factors in human malignant glioma.
Cancer research 1988;48(5):1233-7.
1987: Ballotti R; Nielsen F C; Pringle N; Kowalski A; Richardson W D; Van Obberghen E; Gammeltoft S
Insulin-like growth factor I in cultured rat astrocytes: expression of the gene, and receptor tyrosine kinase.
The EMBO journal 1987;6(12):3633-9.
1987: Tanti J F; Grémeaux T; Rochet N; Van Obberghen E; Le Marchand-Brustel Y
Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity.
The Biochemical journal 1987;245(1):19-26.
1987: Debant A; Guerre-Millo M; Le Marchand-Brustel Y; Freychet P; Lavau M; Van Obberghen E
Insulin receptor kinase is hyperresponsive in adipocytes of young obese Zucker rats.
The American journal of physiology 1987;252(2 Pt 1):E273-8.
1987: Grémeaux T; Tanti J F; Van Obberghen E; Le Marchand-Brustel Y
Polymyxin B selectively inhibits insulin effects on transport in isolated muscle.
The American journal of physiology 1987;252(2 Pt 1):E248-54.
1987: Ballotti R; Kowalski A; White M F; Le Marchand-Brustel Y; Van Obberghen E
Insulin stimulates tyrosine phosphorylation of its receptor beta-subunit in intact rat hepatocytes.
The Biochemical journal 1987;241(1):99-104.
1986: Tanti J F; Grémeaux T; Brandenburg D; Van Obberghen E; Le Marchand-Brustel Y
Brown adipose tissue in lean and obese mice. Insulin-receptor binding and tyrosine kinase activity.
Diabetes 1986;35(11):1243-8.
1986: Carpentier J L; Gazzano H; Van Obberghen E; Fehlmann M; Freychet P; Orci L
Internalization and recycling of 125I-photoreactive insulin-receptor complexes in hepatocytes in primary culture.
Molecular and cellular endocrinology 1986;47(3):243-55.
1986: Ballotti R; Kowalski A; Le Marchand-Brustel Y; Van Obberghen E
Presence of an insulin-stimulated serine kinase in cell extracts from IM-9 cells.
Biochemical and biophysical research communications 1986;139(1):179-85.
1986: Carpentier J L; Gazzano H; Van Obberghen E; Fehlmann M; Freychet P; Orci L
Intracellular pathway followed by the insulin receptor covalently coupled to 125I-photoreactive insulin during internalization and recycling.
The Journal of cell biology 1986;102(3):989-96.
1985: Fehlmann M; Peyron J F; Samson M; Van Obberghen E; Brandenburg D; Brossette N
Molecular association between major histocompatibility complex class I antigens and insulin receptors in mouse liver membranes.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8634-7.
1985: Van Obberghen E; Ballotti R; Gazzano H; Fehlmann M; Rossi B; Gammeltoft S; Debant A; Le Marchand-Brustel Y; Kowalski A
The insulin receptor kinase.
Biochimie 1985;67(10-11):1119-24.
1985: Fehlmann M; Chvatchko Y; Brandenburg D; Van Obberghen E; Brossette N
The subunit structure of the insulin receptor and molecular interactions with major histocompatibility complex antigens.
Biochimie 1985;67(10-11):1155-9.
1985: Le Marchand-Brustel Y; Grémeaux T; Ballotti R; Van Obberghen E
Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice.
Nature 1985;315(6021):676-9.
1985: Sadoul J L; Peyron J F; Ballotti R; Debant A; Fehlmann M; Van Obberghen E
Identification of a cellular 110 000-Da protein substrate for the insulin-receptor kinase.
The Biochemical journal 1985;227(3):887-92.
1985: Gazzano H; Halban P; Prentki M; Ballotti R; Brandenburg D; Fehlmann M; Van Obberghen E
Identification of functional insulin receptors on membranes from an insulin-producing cell line (RINm5F).
The Biochemical journal 1985;226(3):867-72.
1984: Van Obberghen E; Gazzano H; Kowalski A; Fehlmann M; Rossi B; Ponzio G
The insulin receptor-kinase complex: an integrated system for transmembrane hormone signalling.
Biochemical Society transactions 1984;12(5):762-6.
1984: Chvatchko Y; Van Obberghen E; Fehlmann M
Internalization and recycling of insulin receptors in hepatoma cells. Absence of regulation by receptor occupancy.
The Biochemical journal 1984;222(1):111-7.
1984: Brossette N; Van Obberghen E; Fehlmann M
Interaction between insulin receptors and major histocompatibility complex antigens in mouse liver membranes.
Diabetologia 1984;27 Suppl():74-6.
1984: Chvatchko Y; Gazzano H; Van Obberghen E; Fehlmann M
Subunit arrangement of insulin receptors in hepatoma cells.
Molecular and cellular endocrinology 1984;36(1-2):59-65.
1984: van Obberghen E; Gazzano H; Kowalski A
[The insulin receptor: an autonomous system for membrane transmission of the hormonal message]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1984;():29-37.
1983: Kowalski A; Gazzano H; Fehlmann M; Van Obberghen E
Dephosphorylation of the hepatic insulin receptor: absence of intrinsic phosphatase activity in purified receptors.
Biochemical and biophysical research communications 1983;117(3):885-93.
1983: Gazzano H; Kowalski A; Fehlmann M; Van Obberghen E
Two different protein kinase activities are associated with the insulin receptor.
The Biochemical journal 1983;216(3):575-82.
1983: Chvatchko Y; Van Obberghen E; Kiger N; Fehlmann M
Immunoprecipitation of insulin receptors by antibodies against Class 1 antigens of the murine H-2 major histocompatibility complex.
FEBS letters 1983;163(2):207-11.
1983: Van Obberghen E; Rossi B; Kowalski A; Gazzano H; Ponzio G
Receptor-mediated phosphorylation of the hepatic insulin receptor: evidence that the Mr 95,000 receptor subunit is its own kinase.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(4):945-9.

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