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Harold van Rijen

Research Profile

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Patch-Clamp Techniques

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Maartje Noorman; Jeffrey E Saffitz; Michiel van der Heyden; Jasper J van der Smagt; Harold V M van Rijen; Leonie van Stuijvenberg; Andras Varro; Aryan Vink; Marc A Vos; Angeliki Asimaki; Halina Chkourko; Moniek G P J Cox; Jacques M T de Bakker; Nicolaas de Jonge; Roel A de Weger; Mario Delmar; Dennis Dooijes; Judith A Groeneweg; Sara Hakim; Richard N W Hauer; Thomas J Hund; Elise Kessler; Peter J Mohler; Toon A B van Veen
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.
Marina Cerrone; Halina Chkourko; Walter Birchmeier; Thomas Hund; Feng-Xia Liang; Xianming Lin; Peter Mohler; Maartje Noorman; Roel van der Nagel; Harold V M van Rijen; Toon A van Veen; Mario Delmar
Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.
Sevasti-Maria Chaldoupi; Jacques M T de Bakker; Richard N W Hauer; Lisette E G Hubens; Peter Loh; Marcel Nelen; Daan A Smit Duijzentkunst; Egidius E H L van Aarnhem; Harold V M van Rijen; Leonie van Stuijvenberg; Marti F A Bierhuizen; Toon A B van Veen
Reduced connexin40 protein expression in the right atrial appendage of patients bearing the minor connexin40 allele (-44 G --> A).

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All Publications

2013: Maartje Noorman; Jeffrey E Saffitz; Michiel van der Heyden; Jasper J van der Smagt; Harold V M van Rijen; Leonie van Stuijvenberg; Andras Varro; Aryan Vink; Marc A Vos; Angeliki Asimaki; Halina Chkourko; Moniek G P J Cox; Jacques M T de Bakker; Nicolaas de Jonge; Roel A de Weger; Mario Delmar; Dennis Dooijes; Judith A Groeneweg; Sara Hakim; Richard N W Hauer; Thomas J Hund; Elise Kessler; Peter J Mohler; Toon A B van Veen
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.
Heart rhythm : the official journal of the Heart Rhythm Society 2013;10(3):412-9.
2012: Marina Cerrone; Halina Chkourko; Walter Birchmeier; Thomas Hund; Feng-Xia Liang; Xianming Lin; Peter Mohler; Maartje Noorman; Roel van der Nagel; Harold V M van Rijen; Toon A van Veen; Mario Delmar
Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.
Cardiovascular research 2012;95(4):460-8.
2012: Sevasti-Maria Chaldoupi; Jacques M T de Bakker; Richard N W Hauer; Lisette E G Hubens; Peter Loh; Marcel Nelen; Daan A Smit Duijzentkunst; Egidius E H L van Aarnhem; Harold V M van Rijen; Leonie van Stuijvenberg; Marti F A Bierhuizen; Toon A B van Veen
Reduced connexin40 protein expression in the right atrial appendage of patients bearing the minor connexin40 allele (-44 G --> A).
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2012;14(8):1199-205.
2012: Magda S C Fontes; Jacques M T de Bakker; Toon A B van Veen; Harold V M van Rijen
Functional consequences of abnormal Cx43 expression in the heart.
Biochimica et biophysica acta 2012;1818(8):2020-9.
2012: John A Jansen; Ronald Labzowski; Tri Q Nguyen; Carolin M Oefner; Roel van der Nagel; Astrid A Bosch; Jacques M T de Bakker; Sanne de Jong; Helen Driessen; roel goldschmeding; Leonie van Stuijvenberg; Toon A B van Veen; Marc A Vos; Harold V M van Rijen
Reduced Cx43 expression triggers increased fibrosis due to enhanced fibroblast activity.
Circulation. Arrhythmia and electrophysiology 2012;5(2):380-90.
2012: John A Jansen; Peter J Mohler; Hassan Musa; Maartje Noorman; Mèra Stein; Roel van der Nagel; Jacques M T de Bakker; Sanne de Jong; Mario Delmar; Thomas J Hund; Toon A van Veen; Marc A Vos; Harold V M van Rijen
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(4):600-7.
2011: Sanne de Jong; Roel van der Nagel; Jacques M de Bakker; Harold V M van Rijen; Fredy Visser; Marc A Vos; Jaco J Zwanenburg; Peter R Luijten
Direct detection of myocardial fibrosis by MRI.
Journal of molecular and cellular cardiology 2011;51(6):974-9.
2011: Mohamed Boulaksil; Jacques M T de Bakker; Teun P de Boer; Marien J C Houtman; Jerome G Jungschleger; Jos G Maessen; Michiel van der Heyden; Ferenc F van der Hulst; Harold V M van Rijen; Toon A B van Veen; Gudrun Antoons; Jet D M Beekman; Ronald Wilders; Marc A Vos
Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.
Circulation. Arrhythmia and electrophysiology 2011;4(4):566-76.
2011: Sanne de Jong; Toon A B van Veen; Harold V M van Rijen; Jacques M T de Bakker
Fibrosis and cardiac arrhythmias.
Journal of cardiovascular pharmacology 2011;57(6):630-8.
2011: Sanne de Jong; Toon A B van Veen; Jacques M T de Bakker; Marc A Vos; Harold V M van Rijen
Biomarkers of myocardial fibrosis.
Journal of cardiovascular pharmacology 2011;57(5):522-35.
2011: Mèra Stein; Jacques M T de Bakker; Richard N W Hauer; Toon A B van Veen; Harold V M van Rijen
A 50% reduction of excitability but not of intercellular coupling affects conduction velocity restitution and activation delay in the mouse heart.
PloS one 2011;6(6):e20310.
2011: Harold V M van Rijen; Jacques M T de Bakker; Toon A B van Veen
Exciting treatment of reentrant arrhythmias.
Cardiovascular research 2011;89(1):4-5.
2010: Peter Oosterhoff; Morten B Thomsen; Joep N Maas; Nico J M Atteveld; Jet D M Beekman; Harold V M van Rijen; Michiel van der Heyden; Marc A Vos
High-rate pacing reduces variability of repolarization and prevents repolarization-dependent arrhythmias in dogs with chronic AV block.
Journal of cardiovascular electrophysiology 2010;21(12):1384-91.
2010: M Boulaksil; M Noorman; M A Engelen; Toon A B van Veen; Marc A Vos; J M T de Bakker; Harold V M van Rijen
Longitudinal arrhythmogenic remodelling in a mouse model of longstanding pressure overload.
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 2010;18(10):509-15.
2010: Mohamed Boulaksil; Stephan K G Winckels; Markus A Engelen; Mèra Stein; Toon A B van Veen; John A Jansen; André C Linnenbank; Marti F A Bierhuizen; W Antoinette Groenewegen; Matthijs F M van Oosterhout; Johannes H Kirkels; Nicolaas de Jonge; András Varró; Marc A Vos; Jacques M T de Bakker; Harold V M van Rijen
Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmias.
European journal of heart failure 2010;12(9):913-21.
2010: Mera Stein; Mohamed Boulaksil; John A Jansen; Eva Herold; Maartje Noorman; Jaap A Joles; Toon A B van Veen; Marien J C Houtman; Markus A Engelen; Richard N W Hauer; Jacques M T de Bakker; Harold V M van Rijen
Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone system inhibitors in an aged mouse model.
American journal of physiology. Heart and circulatory physiology 2010;299(2):H310-21.
2010: Toon A B van Veen; Jacques M T de Bakker; Lisette E G Hubens; Harold V M van Rijen
Differences in the pattern of ventricular activation in small rodents determined by morphological organization of the cardiac ventricular conduction system.
The Chinese journal of physiology 2010;53(1):52-61.
2010: John A Jansen; Toon A B van Veen; Jacques M T de Bakker; Harold V M van Rijen
Cardiac connexins and impulse propagation.
Journal of molecular and cellular cardiology 2010;48(1):76-82.
2009: Sevasti-Maria Chaldoupi; Peter Loh; Richard N W Hauer; Jacques M T de Bakker; Harold V M van Rijen
The role of connexin40 in atrial fibrillation.
Cardiovascular research 2009;84(1):15-23.
2009: Mèra Stein; Toon A B van Veen; Carol Ann Remme; Mohamed Boulaksil; Maartje Noorman; Leonie van Stuijvenberg; Roel van der Nagel; Connie R Bezzina; Richard N W Hauer; Jacques M T de Bakker; Harold V M van Rijen
Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction.
Cardiovascular research 2009;83(1):52-60.
2009: Maartje Noorman; Marcel A G van der Heyden; Toon A B van Veen; Moniek G P J Cox; Richard N W Hauer; Jacques M T de Bakker; Harold V M van Rijen
Cardiac cell-cell junctions in health and disease: Electrical versus mechanical coupling.
Journal of molecular and cellular cardiology 2009;47(1):23-31.
2008: Toon A B van Veen; Michiel van der Heyden; Harold V M van Rijen
The secrets of hibernators' cardiac conduction reserve.
Heart rhythm : the official journal of the Heart Rhythm Society 2008;5(11):1597-8.
2008: M Noorman; Harold V M van Rijen; Toon A B van Veen; J M T de Bakker; M Stein
Differences in distribution of fibrosis in the ventricles underlie dominant arrhythmia vulnerability of the right ventricle in senescent mice.
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 2008;16(10):356-8.
2008: Marti F A Bierhuizen; Mohamed Boulaksil; Leonie van Stuijvenberg; Roel van der Nagel; Anita T Jansen; Nancy A M Mutsaers; Cansu Yildirim; Toon A B van Veen; Leon J De Windt; Marc A Vos; Harold V M van Rijen
In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms.
Journal of molecular and cellular cardiology 2008;45(3):373-84.
2008: John A Jansen; Teun de Boer; Rianne Wolswinkel; Toon A B van Veen; Marc A Vos; Harold V M van Rijen; Michiel van der Heyden
Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.
Biochemical and biophysical research communications 2008;367(3):687-92.
2008: Mera Stein; Maartje Noorman; Toon A B van Veen; Eva Herold; Markus A Engelen; Mohamed Boulaksil; Gudrun Antoons; John A Jansen; Matthijs F M van Oosterhout; Richard N W Hauer; Jacques M T de Bakker; Harold V M van Rijen
Dominant arrhythmia vulnerability of the right ventricle in senescent mice.
Heart rhythm : the official journal of the Heart Rhythm Society 2008;5(3):438-48.
2007: Harold V M van Rijen; Jacques M T de Bakker
Penetrance of monogenetic cardiac conduction diseases. A matter of conduction reserve?
Cardiovascular research 2007;76(3):379-80.
2007: Jacques M T de Bakker; Harold V M van Rijen
Electrocardiographic manifestation of anatomical substrates underlying post-myocardial infarction tachycardias.
Journal of electrocardiology 2007;40(6 Suppl):S21-5.
2007: Teun de Boer; Harold V M van Rijen; Michiel van der Heyden; Bart Kok; Tobias Opthof; Marc A Vos; Habo J Jongsma; Jacques M T de Bakker; Toon A B van Veen
Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(6):973-81.
2006: Dominik Eckardt; Susanne Kirchhoff; Jung Sun Kim; Joachim Degen; Martin Theis; Thomas Ott; Frank Wiesmann; Pieter A Doevendans; Wouter H Lamers; Jacques M T de Bakker; Harold V M van Rijen; Michael D Schneider; Klaus Willecke
Cardiomyocyte-restricted deletion of connexin43 during mouse development.
Journal of molecular and cellular cardiology 2006;41(6):963-71.
2006: Olaf Krüger; Stephan Maxeiner; Jung Sun Kim; Harold V M van Rijen; Jacques M T de Bakker; Dominik Eckardt; Klaus Tiemann; Thorsten Lewalter; Alexander Ghanem; Bernd Lüderitz; Klaus Willecke
Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45.
Journal of molecular and cellular cardiology 2006;41(5):787-97.
2006: Markus Kretz; Dominik Eckardt; Olaf Krüger; Jung Sun Kim; Jochen Maurer; Martin Theis; Harold V M van Rijen; Hubert Schorle; Klaus Willecke
Normal embryonic development and cardiac morphogenesis in mice with Wnt1-Cre-mediated deletion of connexin43.
Genesis (New York, N.Y. : 2000) 2006;44(6):269-76.
2006: Jörg Stypmann; Markus A Engelen; Constanze Epping; Harold V M van Rijen; Peter Milberg; Christian Bruch; Günter Breithardt; Klaus Tiemann; Lars Eckardt
Age and gender related reference values for transthoracic Doppler-echocardiography in the anesthetized CD1 mouse.
The international journal of cardiovascular imaging 2006;22(3-4):353-62.
2006: Harold V M van Rijen; Toon A B van Veen; Daniel Gros; Ronald Wilders; Jacques M T de Bakker
Connexins and cardiac arrhythmias.
Advances in cardiology 2006;42():150-60.
2006: Toon A B van Veen; Harold V M van Rijen; Habo J Jongsma
Physiology of cardiovascular gap junctions.
Advances in cardiology 2006;42():18-40.
2005: Toon A B van Veen; Harold V M van Rijen; Marjan J A van Kempen; Lucile Miquerol; Tobias Opthof; Daniel Gros; Marc A Vos; Habo J Jongsma; Jacques M T de Bakker
Discontinuous conduction in mouse bundle branches is caused by bundle-branch architecture.
Circulation 2005;112(15):2235-44.
2005: Toon A B van Veen; Mera Stein; Anne Royer; Khai Le Quang; Flavien Charpentier; William H Colledge; Christopher L-H Huang; Ronald Wilders; Andrew A Grace; Denis Escande; Jacques M T de Bakker; Harold V M van Rijen
Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging.
Circulation 2005;112(13):1927-35.
2005: Jacques M T de Bakker; Mera Stein; Harold V M van Rijen
Three-dimensional anatomic structure as substrate for ventricular tachycardia/ventricular fibrillation.
Heart rhythm : the official journal of the Heart Rhythm Society 2005;2(7):777-9.
2005: Anne Royer; Toon A B van Veen; Sabrina Le Bouter; Céline Marionneau; Violaine Griol-Charhbili; Anne-Laure Léoni; Marja Steenman; Harold V M van Rijen; Sophie Demolombe; Catharine Goddard; Christine Richer; Brigitte Escoubet; Thérèse Jarry-Guichard; William H Colledge; Daniel Gros; Jacques M T de Bakker; Andrew A Grace; Denis Escande; Flavien Charpentier
Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis.
Circulation 2005;111(14):1738-46.
2005: Harold V M van Rijen; Jacques M T de Bakker; Toon A B van Veen
Hypoxia, electrical uncoupling, and conduction slowing: Role of conduction reserve.
Cardiovascular research 2005;66(1):9-11.
2004: Lucile Miquerol; Sonia Meysen; Matteo E Mangoni; Patrick Bois; Harold V M van Rijen; Patrice Abran; Habo J Jongsma; Joël Nargeot; Daniel Gros
Architectural and functional asymmetry of the His-Purkinje system of the murine heart.
Cardiovascular research 2004;63(1):77-86.
2004: Harold V M van Rijen; Dominik Eckardt; Joachim Degen; Martin Theis; Thomas Ott; Klaus Willecke; Habo J Jongsma; Tobias Opthof; Jacques M T de Bakker
Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43.
Circulation 2004;109(8):1048-55.
2004: Sébastien Alcoléa; Thérèse Jarry-Guichard; Jacques M T de Bakker; Daniel Gonzàlez; Wouter H Lamers; Steven R Coppen; Luis Barrio; Habo J Jongsma; Daniel Gros; Harold V M van Rijen
Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conduction.
Circulation research 2004;94(1):100-9.
2004: Dominik Eckardt; Martin Theis; Joachim Degen; Thomas Ott; Harold V M van Rijen; Susanne Kirchhoff; Jung Sun Kim; Jacques M T de Bakker; Klaus Willecke
Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletion.
Journal of molecular and cellular cardiology 2004;36(1):101-10.
2003: Richard Derksen; Harold V M van Rijen; Ronald Wilders; Sara Tasseron; Richard N W Hauer; Willem L C Rutten; Jacques M T de Bakker
Tissue discontinuities affect conduction velocity restitution: a mechanism by which structural barriers may promote wave break.
Circulation 2003;108(7):882-8.
2002: Toon A B van Veen; Harold V M van Rijen; Rob F Wiegerinck; Tobias Opthof; Melissa C Colbert; Sophie Clement; Jacques M T de Bakker; Habo J Jongsma
Remodeling of gap junctions in mouse hearts hypertrophied by forced retinoic acid signaling.
Journal of molecular and cellular cardiology 2002;34(10):1411-23.
2001: A A van Veen; Harold V M van Rijen; Tobias Opthof
Cardiac gap junction channels: modulation of expression and channel properties.
Cardiovascular research 2001;51(2):217-29.
2001: Harold V M van Rijen; Toon A B van Veen; Marjan J A van Kempen; Francien J G Wilms-Schopman; Mark Potse; O Krueger; K Willecke; Tobias Opthof; Habo J Jongsma; Jacques M T de Bakker
Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40.
Circulation 2001;103(11):1591-8.
2001: Harold V M van Rijen; Ronald Wilders; Martin B Rook; Habo J Jongsma
Dual patch clamp.
Methods in molecular biology (Clifton, N.J.) 2001;154():269-92.
2000: Toon A B van Veen; Harold V M van Rijen; Habo J Jongsma
Electrical conductance of mouse connexin45 gap junction channels is modulated by phosphorylation.
Cardiovascular research 2000;46(3):496-510.
2000: Harold V M van Rijen; Toon A B van Veen; M M Hermans; Habo J Jongsma
Human connexin40 gap junction channels are modulated by cAMP.
Cardiovascular research 2000;45(4):941-51.
1998: Harold V M van Rijen; Ronald Wilders; Antoni C G van Ginneken; Habo J Jongsma
Quantitative analysis of dual whole-cell voltage-clamp determination of gap junctional conductance.
Pflügers Archiv : European journal of physiology 1998;436(1):141-51.
1998: Harold V M van Rijen; Marjan J A van Kempen; S Postma; Habo J Jongsma
Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells.
Cytokine 1998;10(4):258-64.
1997: Harold V M van Rijen; Marjan J A van Kempen; L J Analbers; Martin B Rook; Antoni C G van Ginneken; Daniel Gros; Habo J Jongsma
Gap junctions in human umbilical cord endothelial cells contain multiple connexins.
The American journal of physiology 1997;272(1 Pt 1):C117-30.