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Nico van Rooijen

Research Profile

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Li-Rung Huang; Craig N Jenne; Zeinab Abdullah; Ru-Lin Cheng; Michael Croft; Hans-Peter Dienes; Natalio Garbi; Mathias Heikenwalder; Paul Kubes; Christian Kurts; Margarete Odenthal; Ulrike Protzer; Florian Reisinger; Frank A Schildberg; Edgar Schmitt; Nico van Rooijen; Dirk Wohlleber; Percy A Knolle
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.
Norihito Kawasaki; Archana Khurana; Mitchell Kronenberg; Corwin M Nycholat; Christoph Rademacher; Nico van Rooijen; Jose Luis Vela; Paul R Crocker; James C Paulson
Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation.
Joana Tavares; Sabine Thiberge; Nico van Rooijen; Pauline Formaglio; Alexander Medvinsky; Robert Ménard; Elodie Mordelet; Rogerio Amino
Role of host cell traversal by the malaria sporozoite during liver infection.

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All Publications

2013: Li-Rung Huang; Craig N Jenne; Zeinab Abdullah; Ru-Lin Cheng; Michael Croft; Hans-Peter Dienes; Natalio Garbi; Mathias Heikenwalder; Paul Kubes; Christian Kurts; Margarete Odenthal; Ulrike Protzer; Florian Reisinger; Frank A Schildberg; Edgar Schmitt; Nico van Rooijen; Dirk Wohlleber; Percy A Knolle
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.
Nature immunology 2013;14(6):574-83.
2013: Norihito Kawasaki; Archana Khurana; Mitchell Kronenberg; Corwin M Nycholat; Christoph Rademacher; Nico van Rooijen; Jose Luis Vela; Paul R Crocker; James C Paulson
Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(19):7826-31.
2013: Joana Tavares; Sabine Thiberge; Nico van Rooijen; Pauline Formaglio; Alexander Medvinsky; Robert Ménard; Elodie Mordelet; Rogerio Amino
Role of host cell traversal by the malaria sporozoite during liver infection.
The Journal of experimental medicine 2013;210(5):905-15.
2013: Katherine I Swenson-Fields; Nico van Rooijen; Carolyn J Vivian; Darren P Wallace; Bradley M Davis; Jacqueline D Peda; Sally M Salah; Timothy A Fields
Macrophages promote polycystic kidney disease progression.
Kidney international 2013;83(5):855-64.
2013: Daigo Hashimoto; Marylene Leboeuf; Daniel Lucas-Alcaraz; Mary Beth Beasley; Christian D Becker; Scott W Boyer; Andrew Chow; E Camilla Forsberg; Paul S. Frenette; Adolfo García-Sastre; Ginhoux Florent; Melanie Greter; Arthur Mortha; Clara Noizat; Jeremy Price; Peter See; E Richard Stanley; Masato Tanaka; Pearline Teo; Nico van Rooijen; Miriam Merad
Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes.
Immunity 2013;38(4):792-804.
2013: Ana Villegas; J Brian de Souza; Emily Gwyer Findlay; Christopher A Hunter; Seen-Wai Lavelle; Eleanor M Riley; Christiaan J Saris; Tovah N Shaw; Nico van Rooijen; Kevin N Couper
IL-27 Receptor Signalling Restricts the Formation of Pathogenic, Terminally Differentiated Th1 Cells during Malaria Infection by Repressing IL-12 Dependent Signals.
PLoS pathogens 2013;9(4):e1003293.
2013: Andrew Chow; Jalal Ahmed; Aviv Bergman; Daigo Hashimoto; Matthew Huggins; Yuya Kunisaki; Marylene Leboeuf; Daniel Lucas; Miriam Merad; Clara Noizat; Sandra Pinho; Masato Tanaka; Nico van Rooijen; Zhizhuang Joe Zhao; Paul S. Frenette
CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.
Nature medicine 2013;19(4):429-36.
2013: Pedro Ramos; Nico van Rooijen; Omar Abdel-Wahab; Laura Breda; Carla Casu; Bart J Crielaard; Benjamin L Ebert; Sara Gardenghi; Saghi Ghaffari; Patricia J Giardina; Robert W Grady; Ritama Gupta; Ella Guy; Ross L Levine; maria franca marongiu; Stefano Rivella
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia.
Nature medicine 2013;19(4):437-45.
2013: Becky J Proskocil; Nico van Rooijen; Donald Bruun; David B Jacoby; Pamela J Lein; Allison Fryer
Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs.
American journal of physiology. Lung cellular and molecular physiology 2013;304(8):L519-29.
2013: Christopher D Conrady; Douglas A Drevets; Derek Royer; Nico van Rooijen; Min Zheng; Anthony Alleman; Daniel J J Carr
Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(6):2807-17.
2013: Vincent Degos; Pierre Gressens; Zhenying Han; Hua Su; Susana Vacas; Nico van Rooijen; William L Young; Mervyn Maze
Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction.
Anesthesiology 2013;118(3):527-36.
2013: Emma L Beckett; Andrew Deane; Paul S Foster; Sahar Hamadi; Irwan Hanish; Nicole G Hansbro; Roberto Adachi; Jay C Horvat; Mark D Inman; Andrew G Jarnicki; Simon Keely; Richard Y Kim; Brian G Oliver; Roy J Soberman; Richard L Stevens; Nico van Rooijen; Peter A Wark; Ming Yang; Philip M Hansbro
A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.
The Journal of allergy and clinical immunology 2013;131(3):752-62.
2013: Matthias Sendler; Nico van Rooijen; Thomas Wartmann; Frank U Weiss; Ali Aghdassi; Annegret Dummer; Walter Halangk; Burkhard Krüger; Markus M Lerch; Sudarshan Ravi Malla; Karin Scharffetter-Kochanek; Julia Mayerle
Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice.
Gut 2013;62(3):430-9.
2013: David A Mancardi; Nico van Rooijen; Marcello Albanesi; Marc Daëron; Patrick England; Bruno Iannascoli; Friederike Jönsson; Xiaoqiang Kang; Pierre Bruhns
The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy.
Blood 2013;121(9):1563-73.
2013: Giovanni Germano; Manuela Liguori; Alberto Mantovani; Sergio Marchini; Roberta Mortarini; Manuela Nebuloni; Fabio Pasqualini; Samantha Pesce; Silvana Pilotti; Roberta Sanfilippo; Sarah Uboldi; Nico van Rooijen; Massimo Zucchetti; Andrea Anichini; Achille Anselmo; Cristina Belgiovine; Luca Beltrame; Paolo G Casali; Maurizio D'Incalci; Eugenio Erba; Roberta Frapolli; Ilaria Fuso Nerini; Carlos M Galmarini; Paola Allavena
Role of macrophage targeting in the antitumor activity of trabectedin.
Cancer cell 2013;23(2):249-62.
2013: Caroline C Duwaerts; Stephan Gehring; Chao-Wen Cheng; Nico van Rooijen; Stephen H Gregory
Contrasting responses of Kupffer cells and inflammatory mononuclear phagocytes to biliary obstruction in a mouse model of cholestatic liver injury.
Liver international : official journal of the International Association for the Study of the Liver 2013;33(2):255-65.
2013: Kouichi Miura; Hirohide Ohnishi; Nico van Rooijen; Ling Yang; David A Brenner; Ekihiro Seki
Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice.
Hepatology (Baltimore, Md.) 2013;57(2):577-89.
2013: Janine M Low-Marchelli; James P Quigley; Nico van Rooijen; Edward A Vizcarra; Veronica C Ardi; Jing Yang
Twist1 induces CCL2 and recruits macrophages to promote angiogenesis.
Cancer research 2013;73(2):662-71.
2013: Li Zhou; Yuqi Zhou; Min Hee Oh; Sun-Young Oh; Clifford M Takemoto; Nico van Rooijen; Yefu Wang; Fan Wu; Baojun Yuan; Tao Zheng; Zhou Zhu
SHP-1 regulation of mast cell function in allergic inflammation and anaphylaxis.
PloS one 2013;8(2):e55763.
2013: Akinobu Kamei; Andrew Y Koh; Gerald B Pier; David C Traficante; Nico van Rooijen; Weihui Wu; Gregory P Priebe
Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia.
The Journal of infectious diseases 2013;207(1):39-49.
2013: Guoxing Zheng; Shibo Zhong; Isaac Cha; Yajun Geng; Godfrey S Getz; Youmin Kang; Gnanasekar Munirathinam; Catherine Reardon-Alulis; Nico van Rooijen; Bin Wang; Aoshuang Chen
Dexamethasone promotes tolerance in vivo by enriching CD11clo CD40lo tolerogenic macrophages.
European journal of immunology 2013;43(1):219-27.
2013: Junko Kato; Norifumi Kawada; Daniel Kirchhofer; Hiroyuki Motoyama; Shuhei Nishiguchi; Tomohiro Okamoto; Hirayuki Enomoto; Jiro Fujimoto; Ryosuke Uchiyama; Nico van Rooijen; Hiroko Tsutsui
Interferon-gamma-mediated tissue factor expression contributes to T-cell-mediated hepatitis through induction of hypercoagulation in mice.
Hepatology (Baltimore, Md.) 2013;57(1):362-72.
2013: C D Conrady; N A Mandal; Nico van Rooijen; M Zheng; D J J Carr
IFN-α-driven CCL2 production recruits inflammatory monocytes to infection site in mice.
Mucosal immunology 2013;6(1):45-55.
2012: Angela C Bradshaw; Lynda Coughlan; Ashley M Miller; Stuart A Nicklin; Nico van Rooijen; Raul Alba; Andrew H Baker
Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses.
Journal of controlled release : official journal of the Controlled Release Society 2012;164(3):394-402.
2012: Xuehua Piao; Günther Schütz; Yasuo Uchiyama; Nico van Rooijen; Hideo Yagita; Hanno Ehlken; Mutsuko Hara; You-Wen He; Masato Koike; Sachiko Komazawa-Sakon; Hidetake Kurihara; Takashi Nishina; Masaki Ohmuraya; Ko Okumura; Jiang-Hu Piao; Hiroyasu Nakano
c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.
Science signaling 2012;5(255):ra93.
2012: Zacarias Garcia; Fabrice Lemaître; Yves Levy; Olivier Schwartz; Nico van Rooijen; Matthew L Albert; Philippe Bousso
Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles.
Blood 2012;120(24):4744-50.
2012: Michael Gliem; Hans-Peter Hartung; Derik Hermsen; Nico van Rooijen; Sebastian Jander
Secondary intracerebral hemorrhage due to early initiation of oral anticoagulation after ischemic stroke: an experimental study in mice.
Stroke; a journal of cerebral circulation 2012;43(12):3352-7.
2012: Katharine D Grugan; Benjamin C Harman; Robert E Jordan; Michelle Kinder; Francis L McCabe; Jeffrey A Nemeth; William R Strohl; Nico van Rooijen; G Mark Anderson; Jason E Ekert; Allison R Greenplate; Randall J Brezski
Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(11):5457-66.
2012: SureshKumar Muthupalani; Barry Rickman; Nico van Rooijen; Yan Feng; Zhongming Ge; Amanda McCabe; Melissa Mobley; James G Fox
Systemic macrophage depletion inhibits Helicobacter bilis-induced proinflammatory cytokine-mediated typhlocolitis and impairs bacterial colonization dynamics in a BALB/c Rag2-/- mouse model of inflammatory bowel disease.
Infection and immunity 2012;80(12):4388-97.
2012: Darragh Duffy; Christelle Liard; Hélène Perrin; Damien Reboulleau; Nico van Rooijen; Bernard Verrier; Valérie Abadie; Nora Benhabiles; Alexandre Boissonnas; Olivia Bonduelle; Christophe Combadière; Benjamin Descours; Béhazine Combadière
Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells.
Immunity 2012;37(5):917-29.
2012: Prakash Ramachandran; Victoria K Snowdon; Nico van Rooijen; Madeleine A Vernon; Mike J Williams; Jonathan R Manning; Antonella Pellicoro; Aysha Ali; Rebecca L Aucott; Luke Boulter; Andrea Cappon; Donald R Dunbar; Jonathan A Fallowfield; Stuart J Forbes; Timothy T Gordon-Walker; Stephen N Hartland; John P Iredale
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(46):E3186-95.
2012: Jill A Poole; Stephen J Reynolds; Debra J Romberger; Nico van Rooijen; William W West; Neil E Alexis; Christopher Bauer; Angela M Gleason; Tammy L Kielian
CD11c(+)/CD11b(+) cells are critical for organic dust-elicited murine lung inflammation.
American journal of respiratory cell and molecular biology 2012;47(5):652-9.
2012: Nicola K Green; Ashley Hale; Chris Herbert; Terry Hermiston; Sam Illingworth; Leonard W Seymour; Vladimir Subr; Karel Ulbrich; Nico van Rooijen; Ryan Cawood; Kerry D Fisher
Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer.
Nanomedicine (London, England) 2012;7(11):1683-95.
2012: Jakob von Moltke; Samantha B Wang; Charles R Brown; Karsten Gronert; Alexander F Kintzer; Bryan A Krantz; Stephen H Leppla; Mahtab Moayeri; Norver J Trinidad; Nico van Rooijen; Russell E Vance
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.
Nature 2012;490(7418):107-11.
2012: Florencia Rosetti; Sanjeev Sethi; George Stavrakis; George C Tsokos; Naotake Tsuboi; Nico van Rooijen; Hiroshi Nishi; Jorge Alcocer-Varela; Kan Chen; Kevin Croce; Thomas Ernandez; Diana Gómez-Martin; Vasileios C Kyttaris; Andrew H Lichtman; Tanya N Mayadas
Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(7):3714-23.
2012: Lauren E Holz; Geoffrey W McCaughan; Claire McGuffog; Nico van Rooijen; Michelle Vo; Volker Benseler; David G Bowen; Patrick Bertolino
Naïve CD8 T cell activation by liver bone marrow-derived cells leads to a "neglected" IL-2low Bimhigh phenotype, poor CTL function and cell death.
Journal of hepatology 2012;57(4):830-6.
2012: Alexander L Rakhmilevich; Tyler J Van De Voort; Nico van Rooijen; Richard K Yang; Mark J Baldeshwiler; Mildred A R Felder; Nicholas A Kalogriopoulos; David S Koslov; Paul M Sondel
Tumor-associated myeloid cells can be activated in vitro and in vivo to mediate antitumor effects.
Cancer immunology, immunotherapy : CII 2012;61(10):1683-97.
2012: Dirk Wohlleber; Bernd Arnold; Carolin Börner; Karin Cederbrant; Hans-Peter Dienes; Marianne K Frings; Katja Gärtner; Günter Hämmerling; Silke Hegenbarth; Mathias Heikenwalder; Hamid Kashkar; Martin Krönke; Christian Kurts; Andreas Limmer; Bernd Nieswandt; Margarete Odenthal; Manolis Pasparakis; Ulrike Protzer; Nico van Rooijen; Percy A Knolle
TNF-induced target cell killing by CTL activated through cross-presentation.
Cell reports 2012;2(3):478-87.
2012: Alexandre P A Theocharides; Nico van Rooijen; Po-Yan Cheng; Jayne S Danska; John E Dick; Jenny M Ho; Liqing Jin; Andrei V Malko; Mark D Minden; Armando G Poeppl; Tatiana K Prasolava; Jean C Y Wang
Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts.
The Journal of experimental medicine 2012;209(10):1883-99.
2012: Kevin Dhaliwal; David A Dorward; Rodger Duffin; David Ferenbach; Michael Gibbons; Christopher Haslett; Nik Hirani; Jeremy Hughes; Duncan Humphries; Matthias Mack; Alison MacKinnon; Andrew Conway Morris; Adriano G Rossi; Emma Scholefield; Nico van Rooijen; William A H Wallace; Tom S Wilkinson; Donald J Davidson; A John Simpson
Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury.
American journal of respiratory and critical care medicine 2012;186(6):514-24.
2012: David J Betting; Sara A Hurvitz; Kamran Kafi; Kristopher K Steward; Nico van Rooijen; Reiko E Yamada; John M Timmerman
Combination of cyclophosphamide, rituximab, and intratumoral CpG oligodeoxynucleotide successfully eradicates established B cell lymphoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2012;35(7):534-43.
2012: Emmanuel L Gautier; Melanie Greter; Andreas J R Habenicht; Claudia Jakubzick; Marylene Leboeuf; Genevieve Marcelin; Miriam Merad; Milena Bogunovic; Andrew Chow; Rainer Spanbroek; Nico van Rooijen; Gwendalyn J Randolph
Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(5):2614-24.
2012: Delu Zhou; Lisa B Noble; Nico van Rooijen; Trinka Vijmasi; Ahmad F Bahrami; Feeling Chen; Ying-Ting Chen; Marianne Gallup; Nancy McNamara
Critical involvement of macrophage infiltration in the development of Sjögren's syndrome-associated dry eye.
The American journal of pathology 2012;181(3):753-60.
2012: Alexandru Schiopu; Nico van Rooijen; Ovidiu S Cotoi; Joanna Hester; Satish N Nadig; Kathryn J Wood
Inflammatory Ly-6C(hi) monocytes play an important role in the development of severe transplant arteriosclerosis in hyperlipidemic recipients.
Atherosclerosis 2012;223(2):291-8.
2012: Janine L Coombes; Seong-Ji Han; David H Raulet; Nico van Rooijen; Ellen A Robey
Infection-induced regulation of natural killer cells by macrophages and collagen at the lymph node subcapsular sinus.
Cell reports 2012;2(1):124-35.
2012: Thomas Naessens; Nico van Rooijen; Seppe Vander Beken; Siegfried Weiss; Pieter Bogaert; Stefaan De Koker; Stefan Lienenklaus; Johan Grooten
Innate imprinting of murine resident alveolar macrophages by allergic bronchial inflammation causes a switch from hypoinflammatory to hyperinflammatory reactivity.
The American journal of pathology 2012;181(1):174-84.
2012: Naheed Choudhry; Franz Petry; Nico van Rooijen; Vincent McDonald
A protective role for interleukin 18 in interferon γ-mediated innate immunity to Cryptosporidium parvum that is independent of natural killer cells.
The Journal of infectious diseases 2012;206(1):117-24.
2012: Michelle Elvington; Yuxiang Huang; B Paul Morgan; Fei Qiao; Carl Atkinson; Nico van Rooijen; Stephen Tomlinson
A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer.
Blood 2012;119(25):6043-51.
2012: Steffen Boettcher; Mathias Heikenwalder; Manfred Kopf; Michael A Schmid; Hitoshi Takizawa; Nico van Rooijen; Patrick Ziegler; Markus G Manz
Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):5824-8.
2012: Claus-Werner Franzke; Keisuke Horiuchi; Thomas Kurz; Stefanie Löffek; David W Threadgill; Antigoni Triantafyllopoulou; Nico van Rooijen; Leena Bruckner-Tuderman; Cristina Cobzaru; Carl P Blobel
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation.
The Journal of experimental medicine 2012;209(6):1105-19.
2012: Michael Gliem; Hans-Peter Hartung; John-Ih Lee; Anne Kathrin Mausberg; Ioannis Simiantonakis; Nico van Rooijen; Sebastian Jander
Macrophages prevent hemorrhagic infarct transformation in murine stroke models.
Annals of neurology 2012;71(6):743-52.
2012: Kouichi Miura; Hirohide Ohnishi; Nico van Rooijen; Ling Yang; Ekihiro Seki
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2.
American journal of physiology. Gastrointestinal and liver physiology 2012;302(11):G1310-21.
2012: Sandra L Silva; Nico van Rooijen; Ana R Vaz; Maria J Diógenes; Adelaide Fernandes; Ana M Sebastião; Rui FM Silva; Dora Brites
Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.
Neuropharmacology 2012;62(7):2398-408.
2012: Patricia Barral; Vincenzo Cerundolo; María Dolores Sánchez-Niño; Nico van Rooijen; Facundo D Batista
The location of splenic NKT cells favours their rapid activation by blood-borne antigen.
The EMBO journal 2012;31(10):2378-90.
2012: Kazuichi Maruyama; Yuko Maruyama; Toru Nakazawa; Nico van Rooijen; Claus Cursiefen; Patricia A D'Amore; Shigeru Kinoshita
The maintenance of lymphatic vessels in the cornea is dependent on the presence of macrophages.
Investigative ophthalmology & visual science 2012;53(6):3145-53.
2012: Nina Linde; Sofia Depner; Claudia M Gutschalk; Wiltrud Lederle; Nico van Rooijen; Margareta M Mueller
Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages.
The Journal of pathology 2012;227(1):17-28.
2012: Molly A Ingersoll; Stephane Potteaux; David Alvarez; Susan B Hutchison; Nico van Rooijen; Gwendalyn J Randolph
Niacin inhibits skin dendritic cell mobilization in a GPR109A independent manner but has no impact on monocyte trafficking in atherosclerosis.
Immunobiology 2012;217(5):548-57.
2012: Luke Boulter; Tom G Bird; Olivier Govaere; John P Iredale; Sally Lowell; Antonella Pellicoro; Sorina Radulescu; Prakash Ramachandran; Rachel A Ridgway; Tania Roskams; Owen J Sansom; Sang Soo Seo; Bart Spee; Nico van Rooijen; Stuart J Forbes
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.
Nature medicine 2012;18(4):572-9.
2012: Sarah Weber; Haijun Tian; Nico van Rooijen; Liise-anne Pirofski
A serotype 3 pneumococcal capsular polysaccharide-specific monoclonal antibody requires Fcγ receptor III and macrophages to mediate protection against pneumococcal pneumonia in mice.
Infection and immunity 2012;80(4):1314-22.
2012: Tomas Drabek; Brad End; Edwin K Jackson; Andreas Janata; Keri L Janesko-Feldman; Jason Stezoski; Samuel A Tisherman; Vincent A Vagni; Nico van Rooijen; Caleb D Wilson; Patrick M Kochanek
Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats.
Resuscitation 2012;83(4):517-26.
2012: Friederike Jönsson; Huot Khun; Yoshihiro Kita; David A Mancardi; Lawrence B Schwartz; Takao Shimizu; Nico van Rooijen; Wei Zhao; Marc Daëron; Bruno Iannascoli; Pierre Bruhns
Human FcγRIIA induces anaphylactic and allergic reactions.
Blood 2012;119(11):2533-44.
2012: Johan Garaude; Andrew Kent; Nico van Rooijen; Julie M. Blander
Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses.
Science translational medicine 2012;4(120):120ra16.
2012: Amy L Anderson; Angela Haczku; Gerold Kierstein; Sonja Kierstein; David F Larosa; Decheng Song; Nico van Rooijen; Yi Zheng; Arnold I Levinson
The B-cell superantigen Finegoldia magna protein L causes pulmonary inflammation by a mechanism dependent on MyD88 but not B cells or immunoglobulins.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2012;61(2):161-9.
2012: Fei Chen; Scott Bowdridge; Zhugong Liu; Ariel Millman; Cristina Rozo; Joseph F Urban; Nico van Rooijen; Wenhui Wu; Thomas A Wynn; William C Gause
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection.
Nature medicine 2012;18(2):260-6.
2012: Clinton S Robbins; Takuya Ueno; Nico van Rooijen; Georg F Weber; Ralph Weissleder; Aleksey Chudnovskiy; Martin Etzrodt; Jose-Luiz Figueiredo; Rostic Gorbatov; Yoshiko Iwamoto; Peter Libby; Mary Jo Mulligan-Kehoe; Matthias Nahrendorf; Mikael J Pittet; Philipp J Rauch; Filip K Swirski
Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions.
Circulation 2012;125(2):364-74.
2012: Linda Ebermann; Carlos A Guzmán; Ulrich Koszinowski; Zsolt Ruzsics; Nico van Rooijen; Rosaely Casalegno-Garduño; Luka Čičin-Šain
Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts.
PLoS pathogens 2012;8(12):e1003062.
2012: Shelley B Weisser; Nico van Rooijen; Laura M Sly
Depletion and reconstitution of macrophages in mice.
Journal of visualized experiments : JoVE 2012;(66):4105.
2012: Hongyu Qiu; Nico van Rooijen; Greg Harris; Rhonda KuoLee; Girishchandra B Patel; Wangxue Chen
Role of macrophages in early host resistance to respiratory Acinetobacter baumannii infection.
PloS one 2012;7(6):e40019.
2012: Hiromi Kumamaru; Hirokazu Saiwai; Nico van Rooijen; Kazuhide Inoue; Yukihide Iwamoto; Kazu Kobayakawa; Kensuke Kubota; Seiji Okada
Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures.
Journal of neuroinflammation 2012;9():116.
2012: Shuai Xiang; Bin-Hao Zhang; Bi-Xiang Zhang; Wei Zhang; Katherine Cianflone; Han-Hua Dong; Song-Qing He; Li Jiang; Kai Jing; Chang-Hai Li; Hui-Fang Liang; Stephen Tomlinson; Nico van Rooijen; Xiao-Ping Chen
Oval cell response is attenuated by depletion of liver resident macrophages in the 2-AAF/partial hepatectomy rat.
PloS one 2012;7(4):e35180.
2012: Isao Miyairi; Nico van Rooijen; Xiaofei Wang; Robert W Williams; Jesse Ziebarth; Gerald Byrne; Jonathan D Laxton; Lu Lu; Yan Cui
Host genetics and Chlamydia disease: prediction and validation of disease severity mechanisms.
PloS one 2012;7(3):e33781.
2012: Jonathan Vinet; Anja Wegner; Nico van Rooijen; Hilmar R J van Weering; Hendrikus W G M Boddeke; Nieske Brouwer; Annette Heinrich; Frank L Heppner; Roland E Kälin; Knut Biber
Neuroprotective function for ramified microglia in hippocampal excitotoxicity.
Journal of neuroinflammation 2012;9():27.
2011: Yukimi Sakoda; Scott E Strome; Nico van Rooijen; Yuming Zhao; Sudarshan Anand; Ling Chen; Lieping Chen; Wayne W Hancock; Atsuo Kuramasu; Yingjia Liu; Jang-June Park; Koji Tamada
Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice.
The Journal of clinical investigation 2011;121(12):4810-9.
2011: Nicolas Lanthier; Patrice Cani; yves horsmans; Olivier Molendi-Coste; Nico van Rooijen; Isabelle Leclercq
Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(12):4301-11.
2011: Zheng Hu; Nico van Rooijen; Yong-Guang Yang
Macrophages prevent human red blood cell reconstitution in immunodeficient mice.
Blood 2011;118(22):5938-46.
2011: Richard Thomas Strait; Keith Stringer; Brian M Susskind; Nico van Rooijen; David Witte; Wyenona Hicks; Marat Khodoun; Jörg Köhl; Ashley Mahler; Nathaniel Barasa; Fred D Finkelman
MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice.
The Journal of experimental medicine 2011;208(12):2525-44.
2011: Matthew A Fischer; Erica L Heipertz; Molly A Ingersoll; Gwendalyn J Randolph; Irene E Reider; Janet J Sei; Nico van Rooijen; Michael L Davies; Melanie R Epler; Christopher C Norbury
CD11b⁺, Ly6G⁺ cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection.
PLoS pathogens 2011;7(11):e1002374.
2011: Marie-Laure Santiago-Raber; Nico van Rooijen; Montserrat Alvarez; Lucie Baudino; Falk Nimmerjahn; Shozo Izui
TLR7/9-mediated monocytosis and maturation of Gr-1(hi) inflammatory monocytes towards Gr-1(lo) resting monocytes implicated in murine lupus.
Journal of autoimmunity 2011;37(3):171-9.
2011: Yuan-yuan Shi; Yan Cai; Hui-yuan Hou; Yu-Sheng Wang; Zhao-xia Zhang; Jing Zhou; Nico van Rooijen
Monocyte/macrophages promote vasculogenesis in choroidal neovascularization in mice by stimulating SDF-1 expression in RPE cells.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2011;249(11):1667-79.
2011: Volker Benseler; Anthony C Allison; David G Bowen; Eamon Breen; Lauren Holz; DAVID LE COUTEUR; Geoffrey W McCaughan; Claire McGuffog; Hans J Schlitt; Szun S Tay; Nico van Rooijen; Michelle Vo; Alessandra Warren; Patrick Bertolino
Hepatocyte entry leads to degradation of autoreactive CD8 T cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(40):16735-40.
2011: Noémi Van Hul; Nico van Rooijen; Jorge Abarca Quinones; Regina Español Suñer; Nicolas Lanthier; Isabelle Leclercq
Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury.
The American journal of pathology 2011;179(4):1839-50.
2011: Ling Zhao; Ruth Elliott; Kristine M Rose; Nico van Rooijen; Susan R Weiss
Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus.
Journal of virology 2011;85(19):10058-68.
2011: Diego Mourão-Sá; Maud Plantinga; Probir Chakravarty; Bart Lambrecht; Rasmus Larsen; Matthew J Robinson; David Sancho; Miguel P Soares; Nico van Rooijen; Santiago Zelenay; Caetano Reis e Sousa
CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses.
European journal of immunology 2011;41(10):3040-53.
2011: Zoë E V Worthington; Nico van Rooijen; Nicholas H Carbonetti
Enhancement of Bordetella parapertussis infection by Bordetella pertussis in mixed infection of the respiratory tract.
FEMS immunology and medical microbiology 2011;63(1):119-28.
2011: Jens Köhler; Cäcilia Renner; Antje Bast; Katrin Breitbach; Anne-Katrin Heitsch; Nico van Rooijen; Silke Vogelgesang; Ivo Steinmetz
NADPH-oxidase but not inducible nitric oxide synthase contributes to resistance in a murine Staphylococcus aureus Newman pneumonia model.
Microbes and infection / Institut Pasteur 2011;13(11):914-22.
2011: Clara Westwell-Roper; Derek L Dai; Jan A Ehses; Kathryn J Potter; Galina Soukhatcheva; Nico van Rooijen; C Bruce Verchere
IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2755-65.
2011: Christopher Schliehe; Marc Thiry; Nico van Rooijen; Horst Weller; Sabrina Engelhardt; Michael Fehlings; Kai Hildner; Marc Mueller; Chiara Redaelli; Marcus Groettrup
CD8- dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2112-21.
2011: Rajeth Koneru; Shoshona Lehrer; Jiadong Li; Nico van Rooijen; Debabrata Banerjee; David Kobiler; John Glod
Macrophages play a key role in early blood brain barrier reformation after hypothermic brain injury.
Neuroscience letters 2011;501(3):148-51.
2011: Shelley B Weisser; Hayley K Brugger; Keith W McLarren; Nico van Rooijen; Nicole S Voglmaier; Laura M Sly
SHIP-deficient, alternatively activated macrophages protect mice during DSS-induced colitis.
Journal of leukocyte biology 2011;90(3):483-92.
2011: Michael A Gibbons; Christopher Haslett; Sarah E Howie; Alison C Mackinnon; Alexander T Phythian-Adams; Prakash Ramachandran; A John Simpson; Nico van Rooijen; Jack Gauldie; Nikhil Hirani; John P Iredale; Tariq Sethi; Kevin Dhaliwal; Rodger Duffin; Stuart J Forbes
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.
American journal of respiratory and critical care medicine 2011;184(5):569-81.
2011: Sang Mi Lee; Steven Rosen; Nico van Rooijen; Philip Weinstein; Linda J Noble-Haeusslein
Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury.
Journal of neurotrauma 2011;28(9):1893-907.
2011: Adriana Flores-Langarica; Ian R Henderson; Jessica Hitchcock; Mahmood Khan; Ian C M MacLennan; Jennifer L Marshall; Elodie Mohr; Ewan A Ross; Nico van Rooijen; Saeeda Bobat; Ruth E Coughlan; Adam F Cunningham
T-zone localized monocyte-derived dendritic cells promote Th1 priming to Salmonella.
European journal of immunology 2011;41(9):2654-65.
2011: Isao Miyairi; Caroline A Obert; Nico van Rooijen; Xiaofei Wang; Venkat R R Arva Tatireddigari; Thomas P Hatch; Jonathan D Laxton; Gerald Byrne
Chlamydia psittaci genetic variants differ in virulence by modulation of host immunity.
The Journal of infectious diseases 2011;204(4):654-63.
2011: Ryan D Kinloch; Choon-Myung Lee; Nico van Rooijen; Edward T Morgan
Selective role for tumor necrosis factor-α, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Biochemical pharmacology 2011;82(3):312-21.
2011: Enric Esplugues; Jeffrey A Bluestone; Nicola Gagliani; Ann M Haberman; Anja E Hauser; Kevan C Herold; Samuel Huber; Yoichiro Iwakura; Jay K Kolls; Vijay K Kuchroo; William O'Connor; Anthony Rongvaux; Terrence Town; Nico van Rooijen; Yisong Y Wan; Richard A Flavell
Control of TH17 cells occurs in the small intestine.
Nature 2011;475(7357):514-8.
2011: Teluguakula Narasaraju; Huck-Hui Ng; Meng-Chee Phoon; Wee Peng Poh; Ramar Perumal Samy; Nico van Rooijen; Edwin Yang; Audrey-Ann Liew; Vincent T Chow
Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis.
The American journal of pathology 2011;179(1):199-210.
2011: Anthony D Dorr; Kieran P O'Dea; Brijesh V Patel; Nico van Rooijen; Alicia C Waite; Kenji Wakabayashi; Michael R Wilson; Masao Takata
Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;111(1):177-84.
2011: Kylie A Alexander; Ming K Chang; David A Hume; Thomas Kohler; Erin R Maylin; Ralph Müller; Liza J Raggatt; Matthew J Sweet; Nico van Rooijen; Andy C Wu; Allison R Pettit
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(7):1517-32.
2011: Jie Chao; Paula Donham; Nico van Rooijen; John G Wood; Norberto C Gonzalez
Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia.
American journal of respiratory cell and molecular biology 2011;45(1):53-61.
2011: Christopher A Iannotti; Jerry Silver; Megan Clark; Kevin Horn; Nico van Rooijen; Michael P Steinmetz
A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI.
Experimental neurology 2011;230(1):3-15.
2011: Stephen J Jenkins; Lucy H Jones; Andrew S MacDonald; Dominik Ruckerl; Nico van Rooijen; Peter C Cook; Fred D Finkelman; Judith E Allen
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation.
Science (New York, N.Y.) 2011;332(6035):1284-8.
2011: Giovanni Sitia; Nico van Rooijen; Ulrich H von Andrian; Matteo Iannacone; Masanori Isogawa; Cristina Scozzesi; Roberto Aiolfi; Marco E Bianchi; Francis V Chisari; Luca G Guidotti
Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis.
PLoS pathogens 2011;7(6):e1002061.
2011: Tatiana Smirnova; Alfred Adomako; Joseph Locker; Nico van Rooijen; Michael B Prystowsky; Jeffrey E Segall
In vivo invasion of head and neck squamous cell carcinoma cells does not require macrophages.
The American journal of pathology 2011;178(6):2857-65.
2011: Katherine Arias; Derek K Chu; Kristin Flader; FM Botelho; Tina Walker; Natalia Arias; Alison A Humbles; Anthony J Coyle; Hans C Oettgen; Hyun-Dong Chang; Nico van Rooijen; Susan Waserman; Manel Jordana
Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice.
The Journal of allergy and clinical immunology 2011;127(6):1552-61.e1.
2011: Connie S Chamberlain; Ellen M Leiferman; Kayt E Frisch; Sijian Wang; Xipei Yang; Nico van Rooijen; Geoff S Baer; Stacey L Brickson; Ray Vanderby
The influence of macrophage depletion on ligament healing.
Connective tissue research 2011;52(3):203-11.
2011: Tracy L McGaha; Yunying Chen; Buvana Ravishankar; Nico van Rooijen; Mikael C I Karlsson
Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen.
Blood 2011;117(20):5403-12.
2011: Daigo Hashimoto; Andrew Chow; Melanie Greter; Yvonne Saenger; Wing-Hong Kwan; Marylene Leboeuf; Ginhoux Florent; Jordi C Ochando; Yuya Kunisaki; Nico van Rooijen; Chen Liu; Takanori Teshima; Peter S Heeger; E Richard Stanley; Paul S. Frenette; Miriam Merad
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation.
The Journal of experimental medicine 2011;208(5):1069-82.
2011: Stephane Potteaux; Emmanuel L Gautier; Susan B Hutchison; Nico van Rooijen; Daniel J Rader; Michael J Thomas; Mary G Sorci-Thomas; Gwendalyn J Randolph
Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression.
The Journal of clinical investigation 2011;121(5):2025-36.
2011: Darko S Markovic; K Vinnakota; Nico van Rooijen; Juergen Kiwit; Michael Synowitz; Rainer Glass; Helmut Kettenmann
Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression.
Brain, behavior, and immunity 2011;25(4):624-8.
2011: Katrina Soderquest; Nick Powell; Carmelo Luci; Nico van Rooijen; Andrés Hidalgo; Frederic Geissmann; Thierry Walzer; Graham M Lord; Alfonso Martín-Fontecha
Monocytes control natural killer cell differentiation to effector phenotypes.
Blood 2011;117(17):4511-8.
2011: Friederike Jönsson; David A Mancardi; Yoshihiro Kita; Hajime Karasuyama; Bruno Iannascoli; Nico van Rooijen; Takao Shimizu; Marc Daëron; Pierre Bruhns
Mouse and human neutrophils induce anaphylaxis.
The Journal of clinical investigation 2011;121(4):1484-96.
2011: Kevin Mott; David Gate; Mandana Zandian; Sariah J Allen; Naveen Kumar Rajasagi; Nico van Rooijen; Shuang Chen; Moshe Arditi; Barry T Rouse; Richard A Flavell; Terrence Town; Homayon Ghiasi
Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs.
Investigative ophthalmology & visual science 2011;52(5):2321-33.
2011: Peter C Cook; Sarah A Aynsley; Joseph D Turner; Gavin R Jenkins; Nico van Rooijen; Mosiuoa Leeto; Frank Brombacher; Adrian P Mountford
Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells.
PLoS pathogens 2011;7(3):e1001323.
2011: Keiko Kataoka; Koji M Nishiguchi; Hiroki Kaneko; Nico van Rooijen; Shu Kachi; Hiroko Terasaki
The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization.
Investigative ophthalmology & visual science 2011;52(3):1431-8.
2011: David A Mancardi; Friederike Jönsson; Bruno Iannascoli; Huot Khun; Nico van Rooijen; Michel Huerre; Marc Daëron; Pierre Bruhns
Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):1899-903.
2011: Daisuke Kurotaki; Shigeyuki Kon; Kyeonghwa Bae; Koyu Ito; Yutaka Matsui; Yosuke Nakayama; Masashi Kanayama; Chiemi Kimura; Yoshinori Narita; Takashi Nishimura; Kazuya Iwabuchi; Matthias Mack; Nico van Rooijen; Shimon Sakaguchi; Toshimitsu Uede; Junko Morimoto
CSF-1-dependent red pulp macrophages regulate CD4 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2229-37.
2011: Andrew Chow; Daniel Lucas-Alcaraz; Andrés Hidalgo; Simón Méndez-Ferrer; Daigo Hashimoto; Christoph A. Scheiermann; Michela Battista; Marylene Leboeuf; Colette Prophete; Nico van Rooijen; Masato Tanaka; Miriam Merad; Paul S. Frenette
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.
The Journal of experimental medicine 2011;208(2):261-71.
2011: Hiroko Oshima; Kyoji Hioki; Boryana K Popivanova; Keisuke Oguma; Nico van Rooijen; Tomo-O Ishikawa; Masanobu Oshima
Prostaglandin E₂ signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors.
Gastroenterology 2011;140(2):596-607.e7.
2011: Hilmar R J van Weering; Hendrikus W G M Boddeke; Jonathan Vinet; Nieske Brouwer; Alexander H de Haas; Nico van Rooijen; Allan R Thomsen; Knut Biber
CXCL10/CXCR3 signaling in glia cells differentially affects NMDA-induced cell death in CA and DG neurons of the mouse hippocampus.
Hippocampus 2011;21(2):220-32.
2011: Pedro Ramos; Ella Guy; Nan Chen; Catia C Proenca; Sara Gardenghi; Carla Casu; Antonia Follenzi; Nico van Rooijen; Robert W Grady; Maria de Sousa; Stefano Rivella
Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis.
Blood 2011;117(4):1379-89.
2011: Francesco Acquati; Sabrina Bertilaccio; Annalisa Grimaldi; Laura Monti; Raffaella Cinquetti; Paolo Bonetti; Marta Lualdi; Laura Vidalino; Marco Fabbri; Maria Grazia Sacco; Nico van Rooijen; Paola Campomenosi; Davide Vigetti; Alberto Passi; Cristina Riva; Carlo Capella; Francesca Sanvito; Claudio Doglioni; Laura Gribaldo; Paolo Macchi; Antonio Sica; Douglas M Noonan; Paolo Ghia; Roberto Taramelli
Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(3):1104-9.
2011: Karim El Bakkouri; Francis Descamps; Marina De Filette; Anouk Smet; Els Festjens; Ashley Birkett; Nico van Rooijen; Sjef Verbeek; Walter Fiers; Xavier Saelens
Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(2):1022-31.
2011: Jae-Min Song; Nico van Rooijen; Jadranka Bozja; Richard W Compans; Sang-Moo Kang
Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(2):757-61.
2011: Aigul Moldobaeva; Nico van Rooijen; Elizabeth M Wagner
Effects of ischemia on lung macrophages.
PloS one 2011;6(11):e26716.
2011: Ana I Arroba; Noemí Alvarez-Lindo; Nico van Rooijen; Enrique J de la Rosa
Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa.
Investigative ophthalmology & visual science 2011;52(12):9124-30.
2011: Bin Feng; Ping Jiao; Dale Jun; Thomas Kim; Yaohui Nie; Nico van Rooijen; Zaiqing Yang; Haiyan Xu
Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice.
PloS one 2011;6(9):e24358.
2011: Chunfeng Wang; Hui Wang; Yuantao Wang; Kentaro Ide; Hideki Ohdan; Nico van Rooijen; Yong-Guang Yang
Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPα capable of binding to human CD47.
Cell transplantation 2011;20(11-12):1915-20.
2011: Jae-Min Song; Bao-Zhong Wang; Kyoung-Mi Park; Nico van Rooijen; Fu-Shi Quan; Min-Chul Kim; Hyun-Tak Jin; Andrew Pekosz; Richard W Compans; Sang-Moo Kang
Influenza virus-like particles containing M2 induce broadly cross protective immunity.
PloS one 2011;6(1):e14538.
2011: Shikha Bhatia; Mingjian Fei; Manohar Yarlagadda; Zengbiao Qi; Shizuo Akira; Shinobu Saijo; Yoichiro Iwakura; Nico van Rooijen; Gregory A Gibson; Claudette M St Croix; Anuradha Ray; Prabir Ray
Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype.
PloS one 2011;6(1):e15943.
2011: Erik E Johnson; Ilia N Buhtoiarov; Mark J Baldeshwiler; Mildred A R Felder; Nico van Rooijen; Paul M Sondel; Alexander L Rakhmilevich
Enhanced T-cell-independent antitumor effect of cyclophosphamide combined with anti-CD40 mAb and CpG in mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2011;34(1):76-84.
2011: Yasuhisa Kanematsu; Miyuki Kanematsu; Chie Kurihara; Yoshiteru Tada; Tsung-Ling Tsou; Nico van Rooijen; Michael T Lawton; William L Young; Elena I Liang; Yoshitsugu Nuki; Tomoki Hashimoto
Critical roles of macrophages in the formation of intracranial aneurysm.
Stroke; a journal of cerebral circulation 2011;42(1):173-8.
2011: Lynne Murray; Qingsheng Chen; Michael S Kramer; David P Hesson; Rochelle L Argentieri; Xueyang Peng; Mridu Gulati; Robert J Homer; Thomas Russell; Nico van Rooijen; Jack A Elias; Cory M Hogaboam; Erica L Herzog
TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P.
The international journal of biochemistry & cell biology 2011;43(1):154-62.
2010: Ingrid G Winkler; Natalie A Sims; Allison R Pettit; Valérie Barbier; Bianca Nowlan; Falak Helwani; Ingrid J Poulton; Nico van Rooijen; Kylie A Alexander; Liza J Raggatt; Jean-Pierre Lévesque
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs.
Blood 2010;116(23):4815-28.
2010: Laurent Detalle; Dan Su; Nico van Rooijen; Jean-Paul Coutelier
Immunoglobulin M antiplatelet autoantibodies from mice immunized with rat platelets induce thrombocytopenia and platelet function impairment.
Experimental biology and medicine (Maywood, N.J.) 2010;235(12):1464-71.
2010: Rinke Stienstra; Leo A B Joosten; Tim Koenen; Berry van Tits; Janna A van Diepen; Sjoerd van den Berg; Patrick C N Rensen; Peter J Voshol; Giamila Fantuzzi; Anneke Hijmans; Sander Kersten; Michael Müller; Wim B van den Berg; Nico van Rooijen; Martin Wabitsch; Bart Jan Kullberg; Jos W M van der Meer; Thirumala Kanneganti; Cees J Tack; Mihai G Netea
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.
Cell metabolism 2010;12(6):593-605.
2010: Cristel Archambaud; Suzana P Salcedo; Hugues Lelouard; Elisabeth Devilard; Beatrice de Bovis; Nico van Rooijen; Jean-Pierre Gorvel; Bernard Malissen
Contrasting roles of macrophages and dendritic cells in controlling initial pulmonary Brucella infection.
European journal of immunology 2010;40(12):3458-71.
2010: Jonathan E Feig; Ines Pineda-Torra; Marie Sanson; Michelle N Bradley; Yuliya Vengrenyuk; Dusan Bogunovic; Emmanuel L Gautier; Daniel Rubinstein; Cynthia Hong; Jianhua Liu; Chaowei Wu; Nico van Rooijen; Nina Bhardwaj; Michael Garabedian; Peter Tontonoz; Edward A Fisher
LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression.
The Journal of clinical investigation 2010;120(12):4415-24.
2010: Esther N Arwert; Rohit Lal; Sven Quist; Ian Rosewell; Nico van Rooijen; Fiona M Watt
Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):19903-8.
2010: Kevin Fabrizio; Catherine Manix; Haijun Tian; Nico van Rooijen; Liise-anne Pirofski
The efficacy of pneumococcal capsular polysaccharide-specific antibodies to serotype 3 Streptococcus pneumoniae requires macrophages.
Vaccine 2010;28(47):7542-50.
2010: Jochen Stritzker; Stephanie Weibel; Carolin Seubert; Andreas Götz; Achim Tresch; Nico van Rooijen; Tobias A Oelschlaeger; Philip J Hill; Ivaylo Gentschev; Aladar A Szalay
Enterobacterial tumor colonization in mice depends on bacterial metabolism and macrophages but is independent of chemotaxis and motility.
International journal of medical microbiology : IJMM 2010;300(7):449-56.
2010: Raul Alba; Angela C Bradshaw; Lynda Coughlan; Laura Denby; Robert A McDonald; Simon Waddington; Suzanne M K Buckley; Jenny A Greig; Alan L Parker; Ashley M Miller; Hongjie Wang; André Lieber; Nico van Rooijen; John H McVey; Stuart A Nicklin; Andrew H Baker
Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors.
Blood 2010;116(15):2656-64.
2010: Florian J Weisel; Uwe K Appelt; Andrea M Schneider; Jasmin U Horlitz; Nico van Rooijen; Heinrich Korner; Michael Mach; Thomas H Winkler
Unique requirements for reactivation of virus-specific memory B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):4011-21.
2010: Adele M Mount; Frederick Masson; Fiona Kupresanin; Christopher M Smith; Janet S May; Nico van Rooijen; Philip G Stevenson; Gabrielle Belz
Interference with dendritic cell populations limits early antigen presentation in chronic γ-herpesvirus-68 infection.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3669-76.
2010: Long V Ly; Aabed Baghat; Mieke Versluis; Ekaterina S. Jordanova; Gregorius P M Luyten; Nico van Rooijen; Thorbald van Hall; Pieter A van der Velden; Martine J Jager
In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3481-8.
2010: Christina D Steel; Woong-Ki Kim; Larry D Sanford; Laurie L Wellman; Sandra Burnett; Nico van Rooijen; Richard P Ciavarra
Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.
Journal of neuroimmunology 2010;226(1-2):81-92.
2010: F Thomas Wunderlich; Peter Ströhle; A Christine Könner; Sabine Gruber; Sulay Tovar; Hella S Brönneke; Lisa Juntti-Berggren; Luo-Sheng Li; Nico van Rooijen; Claude Libert; Per-Olof Berggren; Jens C Brüning
Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action.
Cell metabolism 2010;12(3):237-49.
2010: Ruth F Villarán; Ana M Espinosa-Oliva; Manuel Sarmiento; Rocío M de Pablos; Sandro Argüelles; María J Delgado-Cortés; Verónica Sobrino; Nico van Rooijen; José L Venero; Antonio J Herrera; Josefina Cano; Alberto Machado
Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease.
Journal of neurochemistry 2010;114(6):1687-700.
2010: Andrew J Mitchell; Lydie C Pradel; Lionel Chasson; Nico van Rooijen; Georges E Grau; Nicholas H Hunt; Giovanna Chimini
Technical advance: autofluorescence as a tool for myeloid cell analysis.
Journal of leukocyte biology 2010;88(3):597-603.
2010: Christoph Schmaderer; Ruth Eissler; Sabine Seibel; Nico van Rooijen; Marcus Baumann
Blood pressure control: a facelift for macrophages?
Hypertension 2010;56(2):e23; author reply e24.
2010: Michelle D Tate; Danielle L Pickett; Nico van Rooijen; Andrew G Brooks; Patrick Reading
Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice.
Journal of virology 2010;84(15):7569-80.
2010: Charles Godbout; Rosalie Bilodeau; Nico van Rooijen; Patrice Bouchard; Jérôme Frenette
Transient neutropenia increases macrophage accumulation and cell proliferation but does not improve repair following intratendinous rupture of Achilles tendon.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2010;28(8):1084-91.
2010: Philipp A Lang; Mike Recher; Nadine Honke; Stefanie Scheu; Stephanie Borkens; Nicole Gailus; Caroline Krings; Andreas Meryk; Andreas Kulawik; Luisa Cervantes-Barragan; Nico van Rooijen; Ulrich Kalinke; Burkhard Ludewig; Hans Hengartner; Nicola Harris; Dieter Häussinger; Pamela S Ohashi; Rolf M Zinkernagel; Karl S Lang
Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice.
Hepatology (Baltimore, Md.) 2010;52(1):25-32.
2010: Mercedes Rodriguez Garcia; Levi Ledgerwood; Yu Yang; Jiangnan Xu; Girdhari Lal; Bryna Burrell; Ge Ma; Daigo Hashimoto; Yansui Li; Peter Boros; Marcos Grisotto; Nico van Rooijen; Rafael Matesanz; Frank Tacke; Florent Ginhoux; Yaozhong Ding; Shu-Hsia Chen; Gwendalyn J Randolph; Miriam Merad; Jonathan Bromberg; Jordi C Ochando
Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice.
The Journal of clinical investigation 2010;120(7):2486-96.
2010: Noriyuki Unoki; Tomoaki Murakami; Kazuaki Nishijima; Ken Ogino; Nico van Rooijen; Nagahisa Yoshimura
SDF-1/CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis.
Investigative ophthalmology & visual science 2010;51(7):3362-71.
2010: Carla P Carlos; Glória E F Mendes; André R Miquelin; Marcus A M Luz; Cleonice G A Da Silva; Nico van Rooijen; Terezila M Coimbra; Emmanuel Burdmann
Macrophage depletion attenuates chronic cyclosporine A nephrotoxicity.
Transplantation 2010;89(11):1362-70.
2010: Clotilde Lauro; Raffaela Cipriani; Myriam Catalano; Flavia Trettel; Giuseppina Chece; Valentina Brusadin; Letizia Antonilli; Nico van Rooijen; Fabrizio Eusebi; Bertil B. Fredholm; Cristina Limatola
Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(7):1550-9.
2010: Justin D Ellett; Carl Atkinson; Zachary P Evans; Zainab Amani; Edward Balish; Michael G Schmidt; Nico van Rooijen; Rick G Schnellmann; Kenneth D Chavin
Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(10):5849-58.
2010: Ian A Cockburn; Yun-Chi Chen; Michael G Overstreet; Jason R Lees; Nico van Rooijen; Donna L Farber; Fidel Zavala
Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites.
PLoS pathogens 2010;6(5):e1000877.
2010: José L Reyes; César Terrazas; Javier Alonso-Trujillo; Nico van Rooijen; Abhay R Satoskar; Luis I Terrazas
Early removal of alternatively activated macrophages leads to Taenia crassiceps cysticercosis clearance in vivo.
International journal for parasitology 2010;40(6):731-42.
2010: Patricia Barral; Paolo Polzella; Andreas Bruckbauer; Nico van Rooijen; Gurdyal S Besra; Vincenzo Cerundolo; Facundo D Batista
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.
Nature immunology 2010;11(4):303-12.
2010: Woo Yong Lee; Tara J Moriarty; Connie H Y Wong; Hong Zhou; Robert M Strieter; Nico van Rooijen; George Chaconas; Paul Kubes
An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells.
Nature immunology 2010;11(4):295-302.
2010: Drew M Catron; Kathryn A Pape; Brian T Fife; Nico van Rooijen; Marc K Jenkins
A protease-dependent mechanism for initiating T-dependent B cell responses to large particulate antigens.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3609-17.
2010: Meaghan M Hunter; Arthur Wang; Kuljit S Parhar; Michael J G Johnston; Nico van Rooijen; Paul L Beck; Derek M McKay
In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice.
Gastroenterology 2010;138(4):1395-405.
2010: Ian D Simon; Nico van Rooijen; John K Rose
Vesicular stomatitis virus genomic RNA persists in vivo in the absence of viral replication.
Journal of virology 2010;84(7):3280-6.
2010: Jodi McGill; Nico van Rooijen; Kevin Legge
IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection.
The Journal of experimental medicine 2010;207(3):521-34.
2010: Agnes Machnik; Anke Dahlmann; Christoph Kopp; Jennifer Goss; Hubertus Wagner; Nico van Rooijen; Kai-Uwe Eckardt; Dominik N Müller; Joon-Keun Park; Friedrich C Luft; Dontscho Kerjaschki; Jens Titze
Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats.
Hypertension 2010;55(3):755-61.
2010: Linda D Hazlett; Sharon A McClellan; Ronald Barrett; Xi Huang; Yunfan Zhang; Minhao Wu; Nico van Rooijen; Elizabeth Szliter
IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis.
Investigative ophthalmology & visual science 2010;51(3):1524-32.
2010: Antigoni Triantafyllopoulou; Claus-Werner Franzke; Surya V Seshan; Giorgio Perino; George D Kalliolias; Meera Ramanujam; Nico van Rooijen; Anne Davidson; Lionel B Ivashkiv
Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3012-7.
2010: Yuru Meng; Michael A Beckett; Hua Liang; Helena J Mauceri; Nico van Rooijen; Kenneth S Cohen; Ralph R Weichselbaum
Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy.
Cancer research 2010;70(4):1534-43.
2010: Rinke Stienstra; Fredy Saudale; Caroline Duval; Shohreh Keshtkar; Johanna E M Groener; Nico van Rooijen; Bart Staels; Sander Kersten; Michael Müller
Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity.
Hepatology (Baltimore, Md.) 2010;51(2):511-22.
2010: Jordi Serrats; Jennifer C Schiltz; Borja García-Bueno; Nico van Rooijen; Teresa Reyes; Paul E Sawchenko
Dual roles for perivascular macrophages in immune-to-brain signaling.
Neuron 2010;65(1):94-106.
2010: Jen-Feng Lai; Carlene L Zindl; Lynn B Duffy; T Prescott Atkinson; Yong Woo Jung; Nico van Rooijen; Ken B Waites; Duncan C Krause; David D Chaplin
Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae.
PloS one 2010;5(12):e14417.
2010: Angela C Bradshaw; Alan L Parker; Margaret R Duffy; Lynda Coughlan; Nico van Rooijen; Veli-Matti Kähäri; Stuart A Nicklin; Andrew H Baker
Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X.
PLoS pathogens 2010;6(10):e1001142.
2010: Kwesi Frimpong-Boateng; Nico van Rooijen; Ralf Geiben-Lynn
Regulatory T cells suppress natural killer cells during plasmid DNA vaccination in mice, blunting the CD8+ T cell immune response by the cytokine TGFbeta.
PloS one 2010;5(8):e12281.
2010: Waka Ishida; Ken Fukuda; Mina Kajisako; Ayako Takahashi; Tamaki Sumi; Nico van Rooijen; Atsuki Fukushima
Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis.
Molecular vision 2010;16():1280-5.
2010: Ludovic Arnold; Rajeev Kumar Tyagi; Pedro Mejia; Nico van Rooijen; Jean-Louis Pérignon; Pierre Druilhe
Analysis of innate defences against Plasmodium falciparum in immunodeficient mice.
Malaria journal 2010;9():197.
2010: Nico van Rooijen; Esther Hendrikx
Liposomes for specific depletion of macrophages from organs and tissues.
Methods in molecular biology (Clifton, N.J.) 2010;605():189-203.
2010: Michael Kremer; Emmanuel Thomas; Richard J Milton; Ashley W Perry; Nico van Rooijen; Michael D Wheeler; Steven L Zacks; Michael W Fried; Richard A Rippe; Ian N Hines
Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis.
Hepatology (Baltimore, Md.) 2010;51(1):130-41.
2010: Jane E Mooney; Barbara E Rolfe; Geoffrey W Osborne; David P Sester; Nico van Rooijen; Gordon R Campbell; David A Hume; Julie H Campbell
Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response.
The American journal of pathology 2010;176(1):369-80.
2010: Michelandrea De Cesare; Lucia Sfondrini; Manuela Campiglio; Michele Sommariva; Francesca Bianchi; Paola Perego; Nico van Rooijen; Rosanna Supino; Cristiano Rumio; Franco Zunino; Graziella Pratesi; Elda Tagliabue; Andrea Balsari
Ascites regression and survival increase in mice bearing advanced-stage human ovarian carcinomas and repeatedly treated intraperitoneally with CpG-ODN.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2010;33(1):8-15.
2010: Nicolas Lanthier; Olivier Molendi-Coste; yves horsmans; Nico van Rooijen; Patrice D Cani; Isabelle Leclercq
Kupffer cell activation is a causal factor for hepatic insulin resistance.
American journal of physiology. Gastrointestinal and liver physiology 2010;298(1):G107-16.
2009: Daniel Zecher; Nico van Rooijen; David M Rothstein; Warren D Shlomchik; Fadi G Lakkis
An innate response to allogeneic nonself mediated by monocytes.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7810-6.
2009: Denis Bedoret; Hugues Wallemacq; Thomas Marichal; Christophe Desmet; Florence Quesada Calvo; Emmanuelle Henry; Rodrigue Closset; Benjamin Dewals; Caroline Thielen; Pascal Gustin; Laurence de Leval; Nico van Rooijen; Alain Le Moine; Alain Vanderplasschen; Didier Cataldo; Pierre-Vincent Drion; Muriel Moser; Pierre Lekeux; Fabrice Bureau
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.
The Journal of clinical investigation 2009;119(12):3723-38.
2009: Andrew Y Koh; Gregory P Priebe; Christopher Ray; Nico van Rooijen; Gerald B Pier
Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia.
Infection and immunity 2009;77(12):5300-10.
2009: Mariola Kurowska-Stolarska; Bartosz Stolarski; Peter Kewin; Grace Murphy; Christopher J Corrigan; Sun Ying; Nick Pitman; Ananda Mirchandani; Batika Rana; Nico van Rooijen; Malcolm Shepherd; Charles P McSharry; Iain B McInnes; Damo Xu; Foo Y Liew
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(10):6469-77.
2009: Elzbieta Kolaczkowska; Anna Goldys; Elzbieta Kozakiewicz; Monika Lelito; Barbara Plytycz; Nico van Rooijen; Bernd Arnold
Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation.
Archivum immunologiae et therapiae experimentalis 2009;57(6):459-66.
2009: Pui Y Lee; Yi Li; Yutaro Kumagai; Yuan Xu; Jason S Weinstein; Erinn S Kellner; Dina C Nacionales; Edward J Butfiloski; Nico van Rooijen; Shizuo Akira; Eric S Sobel; Minoru Satoh; Westley H Reeves
Type I interferon modulates monocyte recruitment and maturation in chronic inflammation.
The American journal of pathology 2009;175(5):2023-33.
2009: Eui-Sang Chung; Sunil Kumar Chauhan; Yiping Jin; Shintaro Nakao; Ali Hafezi-Moghadam; Nico van Rooijen; Qiang Zhang; Lu Chen; Reza Dana
Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands.
The American journal of pathology 2009;175(5):1984-92.
2009: Alicia H Clementi; Allison M Gaudy; Nico van Rooijen; Robert H Pierce; Robert A Mooney
Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling.
Biochimica et biophysica acta 2009;1792(11):1062-72.
2009: Gwenaelle Wernli; Wohaib Hasan; Aritra Bhattacherjee; Nico van Rooijen; Peter G Smith
Macrophage depletion suppresses sympathetic hyperinnervation following myocardial infarction.
Basic research in cardiology 2009;104(6):681-93.
2009: Jincun Zhao; Jingxian Zhao; Nico van Rooijen; Stanley Perlman
Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice.
PLoS pathogens 2009;5(10):e1000636.
2009: A K M Ghulam Muhammad; Marianela Candolfi; Gwendalyn D King; Kader Yagiz; David Foulad; Yohei Mineharu; Kurt M Kroeger; Katherine A Treuer; W Stephen Nichols; Nicholas S Sanderson; Jieping Yang; Maksim Khayznikov; Nico van Rooijen; Pedro R Lowenstein; Maria G Castro
Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):6113-27.
2009: Amy S McKee; Michael W Munks; Megan K L MacLeod; Courtney J Fleenor; Nico van Rooijen; John W Kappler; Philippa Marrack
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4403-14.
2009: Katja Fink; Cedrig Ng; Celine Nkenfou; Subhash G Vasudevan; Nico van Rooijen; Wouter Schul
Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control.
European journal of immunology 2009;39(10):2809-21.
2009: Rohini Gupta; Nico van Rooijen; Michael V Sefton
Fate of endothelialized modular constructs implanted in an omental pouch in nude rats.
Tissue engineering. Part A 2009;15(10):2875-87.
2009: Alun C Kirby; Lynette Beattie; Asher Maroof; Nico van Rooijen; Paul M Kaye
SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages.
The American journal of pathology 2009;175(3):1107-15.
2009: Martin Holub; Chao-Wen Cheng; Stephanie Mott; Philip Wintermeyer; Nico van Rooijen; Stephen H Gregory
Neutrophils sequestered in the liver suppress the proinflammatory response of Kupffer cells to systemic bacterial infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):3309-16.
2009: Zhan Ye; Edward J Kerschen; Donald A Cohen; Alan M Kaplan; Nico van Rooijen; Susan C Straley
Gr1+ cells control growth of YopM-negative yersinia pestis during systemic plague.
Infection and immunity 2009;77(9):3791-806.
2009: Michael E Woodman; Anne E Cooley; Rita Avdiushko; Amy Bowman; Marina Botto; R Mark Wooten; Nico van Rooijen; Donald A Cohen; Brian Stevenson
Roles for phagocytic cells and complement in controlling relapsing fever infection.
Journal of leukocyte biology 2009;86(3):727-36.
2009: Monica M Mircescu; Lauren Lipuma; Nico van Rooijen; Eric G Pamer; Tobias M Hohl
Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection.
The Journal of infectious diseases 2009;200(4):647-56.
2009: Michiko Imamura; Hiroko Tsutsui; Koubun Yasuda; Ryosuke Uchiyama; Shizue Yumikura-Futatsugi; Keiko Mitani; Shuhei Hayashi; Shizuo Akira; Shun-Ichiro Taniguchi; Nico van Rooijen; Jurg Tschopp; Tetsuya Yamamoto; Jiro Fujimoto; Kenji Nakanishi
Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice.
Journal of hepatology 2009;51(2):333-41.
2009: Hui Wan; Jojanneke M C Coppens; Cornelia G Van Helden-Meeuwsen; Pieter J M Leenen; Nico van Rooijen; Nisar A Khan; Rebecca C M Kiekens; Robbert Benner; Marjan A Versnel
Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function.
Journal of leukocyte biology 2009;86(2):361-70.
2009: Raul Alba; Angela C Bradshaw; Alan L Parker; David Bhella; Simon Waddington; Stuart A Nicklin; Nico van Rooijen; Jerome Custers; Jaap Goudsmit; Dan H Barouch; John H McVey; Andrew H Baker
Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer.
Blood 2009;114(5):965-71.
2009: Darko S Markovic; K Vinnakota; S Chirasani; Michael Synowitz; H Raguet; K Stock; M Sliwa; S Lehmann; R Kälin; Nico van Rooijen; K Holmbeck; F L Heppner; Juergen Kiwit; Vitali Matyash; S Lehnardt; Bozena Kaminska; Rainer Glass; Helmut Kettenmann
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12530-5.
2009: Ravindra Majeti; Mark P Chao; Ash A Alizadeh; Wendy W Pang; Siddhartha Jaiswal; Kenneth D Gibbs; Nico van Rooijen; Irving L Weissman
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.
Cell 2009;138(2):286-99.
2009: Siddhartha Jaiswal; Catriona H M Jamieson; Wendy W Pang; Christopher Park; Mark P Chao; Ravindra Majeti; David Traver; Nico van Rooijen; Irving L Weissman
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis.
Cell 2009;138(2):271-85.
2009: David J Betting; Reiko E Yamada; Kamran Kafi; Jonathan Said; Nico van Rooijen; John M Timmerman
Intratumoral but not systemic delivery of CpG oligodeoxynucleotide augments the efficacy of anti-CD20 monoclonal antibody therapy against B cell lymphoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2009;32(6):622-31.
2009: Jacqueline G Perrigoue; Steven A Saenz; Mark C Siracusa; Eric J Allenspach; Betsy C Taylor; Paul R Giacomin; Meera G Nair; Yurong Du; Colby Zaph; Nico van Rooijen; Michael R Comeau; Edward J Pearce; Tom Li Stephen; David Artis
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
Nature immunology 2009;10(7):697-705.
2009: Ekihiro Seki; Samuele De Minicis; Sayaka Inokuchi; Kojiro Taura; Katsumi Miyai; Nico van Rooijen; Robert F Schwabe; David A Brenner
CCR2 promotes hepatic fibrosis in mice.
Hepatology (Baltimore, Md.) 2009;50(1):185-97.
2009: Dustin J Donnelly; John C Gensel; Daniel P Ankeny; Nico van Rooijen; Phillip Popovich
An efficient and reproducible method for quantifying macrophages in different experimental models of central nervous system pathology.
Journal of neuroscience methods 2009;181(1):36-44.
2009: Andrea K Horst; Thomas Bickert; Nancy Brewig; Peter Ludewig; Nico van Rooijen; Udo Schumacher; Nicole Beauchemin; Wulf D Ito; Bernhard Fleischer; Christoph Wagener; Uwe Ritter
CEACAM1+ myeloid cells control angiogenesis in inflammation.
Blood 2009;113(26):6726-36.
2009: Peirong Lu; Longbiao Li; Gaoqin Liu; Nico van Rooijen; Naofumi Mukaida; Xueguang Zhang
Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization.
Cornea 2009;28(5):562-9.
2009: Michael R Wilson; Kieran P O'Dea; Da Zhang; Alexander D Shearman; Nico van Rooijen; Masao Takata
Role of lung-marginated monocytes in an in vivo mouse model of ventilator-induced lung injury.
American journal of respiratory and critical care medicine 2009;179(10):914-22.
2009: Ryan Cawood; Hannah H Chen; Fionnadh Carroll; Miriam Bazan-Peregrino; Nico van Rooijen; Leonard W Seymour
Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells.
PLoS pathogens 2009;5(5):e1000440.
2009: Agnes Machnik; Wolfgang Neuhofer; Jonathan Jantsch; Anke Dahlmann; Tuomas Tammela; Katharina Machura; Joon-Keun Park; Franz-Xaver Beck; Dominik N Müller; Wolfgang Derer; Jennifer Goss; Agata Ziomber; Peter Dietsch; Hubertus Wagner; Nico van Rooijen; Armin Kurtz; Karl F Hilgers; Kari Alitalo; Kai-Uwe Eckardt; Friedrich C Luft; Dontscho Kerjaschki; Jens Titze
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Nature medicine 2009;15(5):545-52.
2009: Patricia Redecha; Nico van Rooijen; Donald Torry; Guillermina Girardi
Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury.
Blood 2009;113(17):4101-9.
2009: Sarah N Campion; Cristina Tatis-Rios; Lisa M Augustine; Michael Goedken; Nico van Rooijen; Nathan J Cherrington; José E Manautou
Effect of allyl alcohol on hepatic transporter expression: zonal patterns of expression and role of Kupffer cell function.
Toxicology and applied pharmacology 2009;236(1):49-58.
2009: Lorena Hernandez; Tatiana Smirnova; Dmitriy Kedrin; Jeffrey Bruce Wyckoff; Liyin Zhu; E Richard Stanley; Dianne Cox; William J Muller; Jeffrey W Pollard; Nico van Rooijen; Jeffrey E Segall
The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12.
Cancer research 2009;69(7):3221-7.
2009: Nelson C Di Paolo; Nico van Rooijen; Dmitry M Shayakhmetov
Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(4):675-84.
2009: Sanjoy Roychowdhury; Megan R McMullen; Michele T Pritchard; Amy G Hise; Nico van Rooijen; M Edward Medof; Abram B Stavitsky; Laura E Nagy
An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice.
Hepatology (Baltimore, Md.) 2009;49(4):1326-34.
2009: John C Gensel; Satoshi Nakamura; Zhen Guan; Nico van Rooijen; Daniel P Ankeny; Phillip Popovich
Macrophages promote axon regeneration with concurrent neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(12):3956-68.
2009: Anne M Manicone; Timothy P Birkland; Michelle Lin; Tomoko Betsuyaku; Nico van Rooijen; Jouko Lohi; Jorma Keski-Oja; Ying Wang; Shawn J Skerrett; William C Parks
Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3866-76.
2009: liv eidsmo; Rhys Allan; Irina Caminschi; Nico van Rooijen; William R Heath; Francis R Carbone
Differential migration of epidermal and dermal dendritic cells during skin infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):3165-72.
2009: Harmen R Zandbergen; Umesh C Sharma; Sudhir Gupta; Johan W H Verjans; Susanne van den Borne; Saraswati Pokharel; Thomas van Brakel; Adriaan Duijvestijn; Nico van Rooijen; Jos G Maessen; Chris Reutelingsperger; Yigal M Pinto; Jagat Narula; Leo Hofstra
Macrophage depletion in hypertensive rats accelerates development of cardiomyopathy.
Journal of cardiovascular pharmacology and therapeutics 2009;14(1):68-75.
2009: Kalyan Pande; Roanna Ueda; Todd Machemer; Manjiri Sathe; Van Tsai; Elena Brin; Matthew J Delano; Nico van Rooijen; Terrill K McClanahan; James E Talmadge; Lyle L Moldawer; Joseph H Phillips; Drake M LaFace
Cancer-induced expansion and activation of CD11b+ Gr-1+ cells predispose mice to adenoviral-triggered anaphylactoid-type reactions.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(3):508-15.
2009: Elzbieta Kolaczkowska; Weronika Grzybek; Nico van Rooijen; Helene Piccard; Barbara Plytycz; Bernd Arnold; Ghislain Opdenakker
Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis.
Journal of leukocyte biology 2009;85(3):374-81.
2009: Yoshitsugu Nuki; Melissa M Matsumoto; Eric Tsang; William L Young; Nico van Rooijen; Chie Kurihara; Tomoki Hashimoto
Roles of macrophages in flow-induced outward vascular remodeling.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(3):495-503.
2009: Masja Leendertse; Rob Willems; Ida A J Giebelen; Joris J T H Roelofs; Nico van Rooijen; Marc J M Bonten; Tom van der Poll
Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice.
Innate immunity 2009;15(1):3-12.
2009: Sofia Halin; Stina Häggström Rudolfsson; Nico van Rooijen; Anders Bergh
Extratumoral macrophages promote tumor and vascular growth in an orthotopic rat prostate tumor model.
Neoplasia (New York, N.Y.) 2009;11(2):177-86.
2009: Kieran P O'Dea; Michael R Wilson; Justina O Dokpesi; Kenji Wakabayashi; Louise Tatton; Nico van Rooijen; Masao Takata
Mobilization and margination of bone marrow Gr-1high monocytes during subclinical endotoxemia predisposes the lungs toward acute injury.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):1155-66.
2009: Christer Larsson; Jenny Lundqvist; Nico van Rooijen; Sven Bergström
A novel animal model of Borrelia recurrentis louse-borne relapsing fever borreliosis using immunodeficient mice.
PLoS neglected tropical diseases 2009;3(9):e522.
2009: David E Gyorki; Marie-Liesse Asselin-Labat; Nico van Rooijen; Geoffrey J Lindeman; Jane E Visvader
Resident macrophages influence stem cell activity in the mammary gland.
Breast cancer research : BCR 2009;11(4):R62.
2009: Alan L Parker; Simon Waddington; Suzanne Buckley; Jerome Custers; Menzo J E Havenga; Nico van Rooijen; Jaap Goudsmit; John H McVey; Stuart A Nicklin; Andrew H Baker
Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer.
Journal of virology 2009;83(1):479-83.
2009: Tobias Traeger; Wolfram Kessler; Anne Hilpert; Marlene Mikulcak; Markus Entleutner; Pia Koerner; Alexandra Westerholt; Katharina Cziupka; Nico van Rooijen; Claus-Dieter Heidecke; Stefan Maier
Selective depletion of alveolar macrophages in polymicrobial sepsis increases lung injury, bacterial load and mortality but does not affect cytokine release.
Respiration; international review of thoracic diseases 2009;77(2):203-13.
2008: Ian Galea; Leigh M Felton; Sara Waters; Nico van Rooijen; V Hugh Perry; Tracey A Newman
Immune-to-brain signalling: the role of cerebral CD163-positive macrophages.
Neuroscience letters 2008;448(1):41-6.
2008: Katrin Färber; Michael Synowitz; Grit Zahn; Dörte Vossmeyer; Roland Stragies; Nico van Rooijen; Helmut Kettenmann
An alpha5beta1 integrin inhibitor attenuates glioma growth.
Molecular and cellular neurosciences 2008;39(4):579-85.
2008: Ralf Geiben-Lynn; John R Greenland; Kwesi Frimpong-Boateng; Nico van Rooijen; Avi-Hai Hovav; Norman L Letvin
CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses.
Blood 2008;112(12):4585-90.
2008: Charles M Robertson; Erin E Perrone; Kevin W McConnell; W Michael Dunne; Barrett Boody; Tejal Brahmbhatt; M Julia Diacovo; Nico van Rooijen; Lisa A Hogue; Carolyn Louise Cannon; Timothy G Buchman; Richard S Hotchkiss; Craig M Coopersmith
Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance.
The Journal of surgical research 2008;150(2):278-85.
2008: Jonas Bystrom; Ian Evans; Justine Newson; Melanie Stables; Iqbal Toor; Nico van Rooijen; Mark Crawford; Paul Colville-Nash; Stuart Farrow; Derek W Gilroy
Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP.
Blood 2008;112(10):4117-27.
2008: Stephanie Corjon; Andreas Wortmann; Tatjana Engler; Nico van Rooijen; Stefan Kochanek; Florian Kreppel
Targeting of adenovirus vectors to the LRP receptor family with the high-affinity ligand RAP via combined genetic and chemical modification of the pIX capsomere.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(11):1813-24.
2008: Daniel R Engel; Juliane Maurer; André P Tittel; Christina Weisheit; Taner Cavlar; Beatrix Schumak; Andreas Limmer; Nico van Rooijen; Christian Trautwein; Frank Tacke; Christian Kurts
CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5579-86.
2008: Akiko Okamoto; Keishi Fujio; Nico van Rooijen; Nelson H Tsuno; Koki Takahashi; Hiromichi Tsurui; Sachiko Hirose; Keith B Elkon; Kazuhiko Yamamoto
Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5264-71.
2008: Michaela Fux; Nico van Rooijen; Trevor Owens
Macrophage-independent T cell infiltration to the site of injury-induced brain inflammation.
Journal of neuroimmunology 2008;203(1):64-72.
2008: Vijayshankar Ganesh Sivanandam; Sam Laurel Stephen; Ruben Hernandez-Alcoceba; Pilar Alzuguren; Maider Zabala; Nico van Rooijen; Cheng Qian; Irina Berger; Marie-Luise Gross; Jesus Prieto; Stefan Kochanek
Lethality in an anti-angiogenic tumor gene therapy model upon constitutive but not inducible expression of the soluble vascular endothelial growth factor receptor 1.
The journal of gene medicine 2008;10(10):1083-91.
2008: Sandra J Campbell; Imran Zahid; Patrick Losey; Shing Law; Yanyan Jiang; Mehmet Bilgen; Nico van Rooijen; Damineh Morsali; Andrew E M Davis; Daniel Anthony
Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord.
Neuropharmacology 2008;55(5):780-7.
2008: Keli L Hippen; Paul Harker-Murray; Stephen B Porter; Sarah C Merkel; Aryel Londer; Dawn K Taylor; Megan Bina; Angela Panoskaltsis-Mortari; Pablo Rubinstein; Nico van Rooijen; Tatiana N Golovina; Megan M Suhoski; Jeffrey S Miller; John E Wagner; Carl H June; James L Riley; Bruce R Blazar
Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells.
Blood 2008;112(7):2847-57.
2008: Zimei Zhou; Ronald Barrett; Sharon A McClellan; Yunfan Zhang; Elizabeth A Szliter; Nico van Rooijen; Linda D Hazlett
Substance P delays apoptosis, enhancing keratitis after Pseudomonas aeruginosa infection.
Investigative ophthalmology & visual science 2008;49(10):4458-67.
2008: Daniel R Getts; Rachael L Terry; Daniel Getts; Marcus Müller; Sabita Rana; Bimmi Shrestha; Jane Radford; Nico van Rooijen; Iain L Campbell; Nicholas J C King
Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis.
The Journal of experimental medicine 2008;205(10):2319-37.
2008: Kevin Horn; Sarah Busch; Alicia L Hawthorne; Nico van Rooijen; Jerry Silver
Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(38):9330-41.
2008: Nico van Rooijen
Liposomes for targeting of antigens and drugs: immunoadjuvant activity and liposome-mediated depletion of macrophages.
Journal of drug targeting 2008;16(7):529-34.
2008: Daniel M Appledorn; Sonika Patial; Aaron McBride; Sarah Godbehere; Nico van Rooijen; Narayanan Parameswaran; Andrea Amalfitano
Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):2134-44.
2008: Hongyu Qiu; Yijun Fan; Antony George Joyee; Shuhe Wang; Xiaobing Han; Hong Bai; Lei Jiao; Nico van Rooijen; Xi Yang
Type I IFNs enhance susceptibility to Chlamydia muridarum lung infection by enhancing apoptosis of local macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):2092-102.
2008: Sarah N Campion; Rachel Johnson; Lauren M Aleksunes; Michael Goedken; Nico van Rooijen; George L Scheffer; Nathan J Cherrington; José E Manautou
Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(2):G294-304.
2008: Oliver Soehnlein; S Oehmcke; X Ma; Antonio Gigliotti Rothfuchs; Robert Frithiof; Nico van Rooijen; M Mörgelin; Heiko Herwald; Lennart Lindbom
Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(2):405-12.
2008: Phillip H Horne; Jason M Zimmerer; Mason G Fisher; Keri E Lunsford; Gyongyi Nadasdy; Tibor Nadasdy; Nico van Rooijen; Ginny L Bumgardner
Critical role of effector macrophages in mediating CD4-dependent alloimmune injury of transplanted liver parenchymal cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1224-31.
2008: Jodi McGill; Nico van Rooijen; Kevin Legge
Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs.
The Journal of experimental medicine 2008;205(7):1635-46.
2008: Milan Theurl; Igor Theurl; Kathrin Hochegger; Peter Obrist; Nathan Subramaniam; Nico van Rooijen; Klaus Schuemann; Guenter Weiss
Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression.
Journal of molecular medicine (Berlin, Germany) 2008;86(7):825-35.
2008: Aiping Zhao; Joseph F Urban; Robert M Anthony; Rex Sun; Jennifer Stiltz; Nico van Rooijen; Thomas A Wynn; William C Gause; Terez Shea-Donohue
Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages.
Gastroenterology 2008;135(1):217-225.e1.
2008: Brett A Lidbury; Nestor E Rulli; Andreas Suhrbier; Paul N Smith; Shaun R McColl; Anthony L Cunningham; Andrej Tarkowski; Nico van Rooijen; Robert J Fraser; Surendran Mahalingam
Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus.
The Journal of infectious diseases 2008;197(11):1585-93.
2008: Kimberly M Roth; Steve Oghumu; Anjali A Satoskar; John S Gunn; Nico van Rooijen; Abhay R Satoskar
Respiratory infection with Francisella novicida induces rapid dystrophic cardiac calcinosis (DCC).
FEMS immunology and medical microbiology 2008;53(1):72-8.
2008: Claudia Rival; M S Theas; M O Suescun; P Jacobo; V Guazzone; Nico van Rooijen; Livia Lustig
Functional and phenotypic characteristics of testicular macrophages in experimental autoimmune orchitis.
The Journal of pathology 2008;215(2):108-17.
2008: Luciana Borsoi Moraes; Abel Hiroshi F Murakami; Belchor Fontes; Renato Sérgio Poggetti; Nico van Rooijen; Riad N Younes; Ana Maria Cattani Heimbecker; Dario Birolini
Gut ischemia/reperfusion induced acute lung injury is an alveolar macrophage dependent event.
The Journal of trauma 2008;64(5):1196-200; discussion 1200-1.
2008: Maria Kaparakis; Anna Walduck; Jason D Price; John S Pedersen; Nico van Rooijen; Martin J Pearse; Odilia L C Wijburg; Richard A Strugnell
Macrophages are mediators of gastritis in acute Helicobacter pylori infection in C57BL/6 mice.
Infection and immunity 2008;76(5):2235-9.
2008: Erik N T P Bakker; Hanke L Matlung; Peter Bonta; Carlie J M de Vries; Nico van Rooijen; Ed VanBavel
Blood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone.
Cardiovascular research 2008;78(2):341-8.
2008: Heui Man Kim; Young-Won Lee; Ki-Ja Lee; Hyun Soo Kim; Sung Whan Cho; Nico van Rooijen; Yi Guan; Sang Heui Seo
Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs.
Journal of virology 2008;82(9):4265-74.
2008: Y Huang; Ling-Ping Cen; J-M Luo; N Wang; M-Z Zhang; Nico van Rooijen; Chi Pui Pang; Q Cui
Differential roles of phosphatidylinositol 3-kinase/akt pathway in retinal ganglion cell survival in rats with or without acute ocular hypertension.
Neuroscience 2008;153(1):214-25.
2008: Nathan R Miselis; Zhijin J Wu; Nico van Rooijen; Agnes B Kane
Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma.
Molecular cancer therapeutics 2008;7(4):788-99.
2008: Pui Y Lee; Jason S Weinstein; Dina C Nacionales; Philip O Scumpia; Yi Li; Edward J Butfiloski; Nico van Rooijen; Lyle Moldawer; Minoru Satoh; Westley H Reeves
A novel type I IFN-producing cell subset in murine lupus.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):5101-8.
2008: Daniela Fraccarollo; Paolo Galuppo; Susanne Schraut; Susanne Kneitz; Nico van Rooijen; Georg Ertl; Johann Bauersachs
Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response.
Hypertension 2008;51(4):905-14.
2008: Claudia Jakubzick; Frank Tacke; Ginhoux Florent; Amy J Wagers; Nico van Rooijen; Matthias Mack; Miriam Merad; Gwendalyn J Randolph
Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3019-27.
2008: Andrew Y Koh; Julia R Köhler; Kathleen T Coggshall; Nico van Rooijen; Gerald B Pier
Mucosal damage and neutropenia are required for Candida albicans dissemination.
PLoS pathogens 2008;4(2):e35.
2008: Simon Waddington; John H McVey; David Bhella; Alan L Parker; Kristeen Barker; Hideko Atoda; Rebecca Pink; Suzanne Buckley; Jenny A Greig; Laura Denby; Jerome Custers; Takashi Morita; Ivo M B Francischetti; Robson Q Monteiro; Dan H Barouch; Nico van Rooijen; Claudio Napoli; Menzo J E Havenga; Stuart A Nicklin; Andrew H Baker
Adenovirus serotype 5 hexon mediates liver gene transfer.
Cell 2008;132(3):397-409.
2008: Margaret M Kelly; Kelly McNagny; David L Williams; Nico van Rooijen; Lori Maxwell; Carol Gwozd; Christopher H Mody; Paul Kubes
The lung responds to zymosan in a unique manner independent of toll-like receptors, complement, and dectin-1.
American journal of respiratory cell and molecular biology 2008;38(2):227-38.
2008: Scott C Bryer; Giamila Fantuzzi; Nico van Rooijen; Timothy J Koh
Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):1179-88.
2008: Linda M Wakim; Jason Waithman; Nico van Rooijen; William R Heath; Francis R Carbone
Dendritic cell-induced memory T cell activation in nonlymphoid tissues.
Science (New York, N.Y.) 2008;319(5860):198-202.
2008: Yao Huang; Zhiwei Li; Ningli Wang; Nico van Rooijen; Qi Cui
Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds.
BMC neuroscience 2008;9():78.
2008: Adrian Pistea; Erik N T P Bakker; Jos A E Spaan; Max R Hardeman; Nico van Rooijen; Ed VanBavel
Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: role of transglutaminases.
Journal of vascular research 2008;45(1):10-8.
2007: Ezogelin Oflazoglu; Ivan Stone; Kristine A Gordon; Iqbal Grewal; Nico van Rooijen; Che-Leung Law; Hans-Peter Gerber
Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30.
Blood 2007;110(13):4370-2.
2007: Kevin Mott; David J Brick; Nico van Rooijen; Homayon Ghiasi
Macrophages are important determinants of acute ocular HSV-1 infection in immunized mice.
Investigative ophthalmology & visual science 2007;48(12):5605-15.
2007: Kevin N Couper; Daniel G Blount; Julius Hafalla; Nico van Rooijen; J Brian de Souza; Eleanor M Riley
Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia.
Infection and immunity 2007;75(12):5806-18.
2007: Jason D Price; Kim R Simpfendorfer; Radhakrishnam R Mantena; James Holden; William R Heath; Nico van Rooijen; Richard A Strugnell; Odilia L C Wijburg
Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar Typhimurium.
Infection and immunity 2007;75(12):5753-62.
2007: Elzbieta Kolaczkowska; Monika Lelito; Elzbieta Kozakiewicz; Nico van Rooijen; Barbara Plytycz; Bernd Arnold
Resident peritoneal leukocytes are important sources of MMP-9 during zymosan peritonitis: superior contribution of macrophages over mast cells.
Immunology letters 2007;113(2):99-106.
2007: Aaron S Borders; M A Hersh; Marilyn L Getchell; Nico van Rooijen; Donald A Cohen; Arnold J Stromberg; Thomas V Getchell
Macrophage-mediated neuroprotection and neurogenesis in the olfactory epithelium.
Physiological genomics 2007;31(3):531-43.
2007: Christian Fischer; Bart Jonckx; Massimiliano Mazzone; Serena Zacchigna; Sonja Loges; Lucia Pattarini; Emmanuel Chorianopoulos; Laurens Liesenborghs; Marta Koch; Maria De Mol; Monica Autiero; Sabine Wyns; Stephane Plaisance; Lieve Moons; Nico van Rooijen; Mauro Giacca; Jean Marie Stassen; Mieke Dewerchin; Désiré Collen; Peter Carmeliet
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.
Cell 2007;131(3):463-75.
2007: Tobias Junt; E Ashley Moseman; Matteo Iannacone; Steffen Massberg; Philipp A Lang; Marianne Boes; Katja Fink; Sarah Henrickson; Dmitry M Shayakhmetov; Nelson C Di Paolo; Nico van Rooijen; Thorsten R Mempel; Sean Whelan; Ulrich H von Andrian
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells.
Nature 2007;450(7166):110-4.
2007: Yao Huang; Ling-Ping Cen; Kwong Wai Choy; Nico van Rooijen; Ningli Wang; Chi Pui Pang; Qi Cui
JAK/STAT pathway mediates retinal ganglion cell survival after acute ocular hypertension but not under normal conditions.
Experimental eye research 2007;85(5):684-95.
2007: Yao Huang; Zhiwei Li; Nico van Rooijen; Ningli Wang; Chi Pui Pang; Qi Cui
Different responses of macrophages in retinal ganglion cell survival after acute ocular hypertension in rats with different autoimmune backgrounds.
Experimental eye research 2007;85(5):659-66.
2007: Kota Arun Kumar; Celia R S Garcia; Vandana R Chandran; Nico van Rooijen; Yingyao Zhou; Elizabeth A Winzeler; Victor Nussenzweig
Exposure of Plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity.
Molecular and biochemical parasitology 2007;156(1):32-40.
2007: Michael A Flierl; Daniel Rittirsch; Brian A Nadeau; Anthony J Chen; J Vidya Sarma; Firas S Zetoune; Stephanie R McGuire; Rachel P List; Danielle E Day; Laszlo M Hoesel; Hongwei Gao; Nico van Rooijen; Markus Huber-Lang; Richard Neubig; Peter A Ward
Phagocyte-derived catecholamines enhance acute inflammatory injury.
Nature 2007;449(7163):721-5.
2007: Giulia Fulci; Nina Dmitrieva; Davide Gianni; Elisabeth J Fontana; Xiaogang Pan; Yanhui Lu; Claire S Kaufman; Balveen Kaur; Sean E Lawler; Robert J Lee; Clay B Marsh; Daniel J Brat; Nico van Rooijen; Anat Stemmer-Rachamimov; Anat Stemmer Rachamimov; Fred H Hochberg; Ralph Weissleder; Robert L Martuza; E Antonio Chiocca
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.
Cancer research 2007;67(19):9398-406.
2007: Caspar Ohnmacht; Andrea Pullner; Nico van Rooijen; David Voehringer
Analysis of eosinophil turnover in vivo reveals their active recruitment to and prolonged survival in the peritoneal cavity.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4766-74.
2007: Norberto C Gonzalez; Julie Allen; V Gustavo Blanco; Eric J Schmidt; Nico van Rooijen; John G Wood
Alveolar macrophages are necessary for the systemic inflammation of acute alveolar hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;103(4):1386-94.
2007: Dana M DiPasquale; Ming Cheng; William Billich; Sharon A Huang; Nico van Rooijen; Troy A Hornberger; Timothy J Koh
Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in mice.
American journal of physiology. Cell physiology 2007;293(4):C1278-85.
2007: Chantal A Rivera; Patrick A Adegboyega; Nico van Rooijen; Arlene Tagalicud; Monique Allman; Matthew Wallace
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis.
Journal of hepatology 2007;47(4):571-9.
2007: Florian R Greten; Melek C Arkan; Julia Bollrath; Li-Chung Hsu; Jason Goode; Cornelius Miething; Serkan I Göktuna; Michael Neuenhahn; Joshua Fierer; Stephan Paxian; Nico van Rooijen; Yajun Xu; Timothy O'Cain; Bruce B Jaffee; Dirk H Busch; Justus Duyster; Roland M Schmid; Lars Eckmann; Michael Karin
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
Cell 2007;130(5):918-31.
2007: Ian Galea; Martine Bernardes-Silva; Penny A Forse; Nico van Rooijen; Roland S Liblau; V Hugh Perry
An antigen-specific pathway for CD8 T cells across the blood-brain barrier.
The Journal of experimental medicine 2007;204(9):2023-30.
2007: Sanjay Khandelwal; Nico van Rooijen; Rajiv K Saxena
Reduced expression of CD47 during murine red blood cell (RBC) senescence and its role in RBC clearance from the circulation.
Transfusion 2007;47(9):1725-32.
2007: Ling-Ping Cen; Jian-Min Luo; Cheng-Wu Zhang; You-Ming Fan; Yue Song; Kwok-Fai So; Nico van Rooijen; Chi Pui Pang; Dennis S C Lam; Qi Cui
Chemotactic effect of ciliary neurotrophic factor on macrophages in retinal ganglion cell survival and axonal regeneration.
Investigative ophthalmology & visual science 2007;48(9):4257-66.
2007: Dirk Bauer; Susanne Wasmuth; Pia Hermans; Maren Hennig; Karl Meller; Daniel Meller; Nico van Rooijen; Scheffer C G Tseng; Klaus-Peter Steuhl; Arnd Heiligenhaus
On the influence of neutrophils in corneas with necrotizing HSV-1 keratitis following amniotic membrane transplantation.
Experimental eye research 2007;85(3):335-45.
2007: Hui Wang; Maria Lucia Madariaga; Shumei Wang; Nico van Rooijen; Per-Arne Oldenborg; Yong-Guang Yang
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13744-9.
2007: Jian-Min Luo; Ling-Ping Cen; Xin-Mei Zhang; Sylvia Wai-Yee Chiang; Yao Huang; Dusheng Lin; You-Ming Fan; Nico van Rooijen; Dennis Shun Chiu Lam; Chi Pui Pang; Qi Cui
PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury.
The European journal of neuroscience 2007;26(4):828-42.
2007: Silvina Gazzaniga; Alicia I Bravo; Angelo Guglielmotti; Nico van Rooijen; Fabricio Maschi; Annunciata Vecchi; Alberto Mantovani; José Mordoh; Rosa Wainstok
Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft.
The Journal of investigative dermatology 2007;127(8):2031-41.
2007: Toni M Robinson-Smith; Idit Isaacsohn; Carol A Mercer; Mingfu Zhou; Nico van Rooijen; Nader Husseinzadeh; Molly McFarland-Mancini; Angela F Drew
Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice.
Cancer research 2007;67(12):5708-16.
2007: Ludovic Arnold; Adeline Henry; Françoise Poron; Yasmine Baba-Amer; Nico van Rooijen; Anne Plonquet; Romain K Gherardi; Bénédicte Chazaud
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis.
The Journal of experimental medicine 2007;204(5):1057-69.
2007: Tiffany A Reese; Hong-Erh Liang; Andrew M Tager; Andrew D Luster; Nico van Rooijen; David Voehringer; Richard M Locksley
Chitin induces accumulation in tissue of innate immune cells associated with allergy.
Nature 2007;447(7140):92-6.
2007: Joseph D Mocanu; Kenneth W Yip; Nehad M Alajez; Wei Shi; Jian-Hua Li; Sarah J Lunt; Eduardo H Moriyama; Brian C Wilson; Michael Milosevic; Kwok-Wai Lo; Nico van Rooijen; Pierre Busson; Carlo Bastianutto; Fei-Fei Liu
Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(5):921-9.
2007: Philip Smith; Niamh E Mangan; Caitriona M Walsh; Rosie E Fallon; Andrew N J McKenzie; Nico van Rooijen; Padraic G Fallon
Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4557-66.
2007: Nicholas H Carbonetti; Galina V Artamonova; Nico van Rooijen; Victor Ayala
Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract.
Infection and immunity 2007;75(4):1713-20.
2007: Aaron S Borders; Marilyn L Getchell; Jordan T Etscheidt; Nico van Rooijen; Donald A Cohen; Thomas V Getchell
Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis.
The Journal of comparative neurology 2007;501(2):206-18.
2007: Machteld J van Amerongen; Martin C Harmsen; Nico van Rooijen; Arjen H Petersen; Marja J A van Luyn
Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice.
The American journal of pathology 2007;170(3):818-29.
2007: Michael Gray; Winnie Palispis; Phillip Popovich; Nico van Rooijen; Ranjan Gupta
Macrophage depletion alters the blood-nerve barrier without affecting Schwann cell function after neural injury.
Journal of neuroscience research 2007;85(4):766-77.
2007: Patric Lundberg; Paula Welander; Carl K Edwards; Nico van Rooijen; Edouard Cantin
Tumor necrosis factor (TNF) protects resistant C57BL/6 mice against herpes simplex virus-induced encephalitis independently of signaling via TNF receptor 1 or 2.
Journal of virology 2007;81(3):1451-60.
2007: Julie A McEarchern; Ezogelin Oflazoglu; Leigh Francisco; Charlotte F McDonagh; Kristine A Gordon; Ivan Stone; Kerry Klussman; Eileen Turcott; Nico van Rooijen; Paul Carter; Iqbal Grewal; Alan F Wahl; Che-Leung Law
Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities.
Blood 2007;109(3):1185-92.
2007: Kerstin Baer; Michael Roosevelt; Allen B Clarkson; Nico van Rooijen; Thomas Schnieder; Ute Frevert
Kupffer cells are obligatory for Plasmodium yoelii sporozoite infection of the liver.
Cellular microbiology 2007;9(2):397-412.
2007: Frank Tacke; David Alvarez; Theodore J Kaplan; Claudia Jakubzick; Rainer Spanbroek; Jaime Llodra; Alexandre Garin; Jianhua Liu; Matthias Mack; Nico van Rooijen; sergio lira; Andreas J R Habenicht; Gwendalyn J Randolph
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques.
The Journal of clinical investigation 2007;117(1):185-94.
2007: Arjen B Blom; P L E M van Lent; Sten Libregts; A E M Holthuysen; Peter van der Kraan; Nico van Rooijen; Wim B van den Berg
Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3.
Arthritis and rheumatism 2007;56(1):147-57.
2006: Glaucia C Furtado; Beatrice Piña; Frank Tacke; Stefanie Gaupp; Nico van Rooijen; Thomas M Moran; Gwendalyn J Randolph; Richard M Ransohoff; Stephen W Chensue; Cedric S Raine; sergio lira
A novel model of demyelinating encephalomyelitis induced by monocytes and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6871-9.
2006: Katrin Breitbach; Sonja Klocke; Thomas Tschernig; Nico van Rooijen; Ulrich Baumann; Ivo Steinmetz
Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice.
Infection and immunity 2006;74(11):6300-9.
2006: Sander Keijser; R J W De Keizer; Frans A Prins; H J Tanke; Nico van Rooijen; Gijs F J M Vrensen; Martine J Jager
A new model for limbal transplantation using E-GFP for follow-up of transplant survival.
Experimental eye research 2006;83(5):1188-95.
2006: Joseph E Qualls; Alan M Kaplan; Nico van Rooijen; Donald A Cohen
Suppression of experimental colitis by intestinal mononuclear phagocytes.
Journal of leukocyte biology 2006;80(4):802-15.
2006: Michael Synowitz; Rainer Glass; Katrin Färber; Darko S Markovic; Golo Kronenberg; Ken Herrmann; Juergen Schnermann; Christiane Nolte; Nico van Rooijen; Juergen Kiwit; Helmut Kettenmann
A1 adenosine receptors in microglia control glioblastoma-host interaction.
Cancer research 2006;66(17):8550-7.
2006: Julien Crettaz; Pedro Berraondo; Itsaso Mauleón; Laura Ochoa; Vijay Shankar; Miguel Barajas; Nico van Rooijen; Stefan Kochanek; Cheng Qian; Jesús Prieto; Rubén Hernández-Alcoceba; L Ochoa-Callejero; Gloria González-Aseguinolaza
Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in mice.
Hepatology (Baltimore, Md.) 2006;44(3):623-32.
2006: Jennifer Louten; Nico van Rooijen; Christine A Biron
Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3266-72.
2006: Robert M Anthony; Joseph F Urban; Farhang Alem; Hossein Hamed; Cristina T Rozo; Jean-Luc Boucher; Nico van Rooijen; William C Gause
Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites.
Nature medicine 2006;12(8):955-60.
2006: Honglin Wang; Thorsten Peters; Daniel Kess; Anca Sindrilaru; Tsvetelina Oreshkova; Nico van Rooijen; Athanasios Stratis; Andreas C Renkl; Cord Sunderkötter; Meinhard Wlaschek; Ingo Haase; Karin Scharffetter-Kochanek
Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation.
The Journal of clinical investigation 2006;116(8):2105-14.
2006: Athanasios Stratis; Manolis Pasparakis; Rudolf A Rupec; Doreen Markur; Karin Hartmann; Karin Scharffetter-Kochanek; Thorsten Peters; Nico van Rooijen; Thomas Krieg; Ingo Haase
Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation.
The Journal of clinical investigation 2006;116(8):2094-104.
2006: Erik N T P Bakker; Adrian Pistea; Jos A E Spaan; Titia M Rolf; Carlie J M de Vries; Nico van Rooijen; Eleonara Candi; Ed VanBavel
Flow-dependent remodeling of small arteries in mice deficient for tissue-type transglutaminase: possible compensation by macrophage-derived factor XIII.
Circulation research 2006;99(1):86-92.
2006: Zita F H M Boonman; Lucas R H M Schurmans; Nico van Rooijen; Cornelis J M Melief; René E M Toes; Martine J Jager
Macrophages are vital in spontaneous intraocular tumor eradication.
Investigative ophthalmology & visual science 2006;47(7):2959-65.
2006: Elzbieta Kolaczkowska; Anna Scislowska-Czarnecka; Magdalena Chadzinska; Barbara Plytycz; Nico van Rooijen; Ghislain Opdenakker; Bernd Arnold
Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage origin.
Journal of leukocyte biology 2006;80(1):125-32.
2006: Mukesh Summan; Gordon L Warren; Robert R Mercer; Rebecca Chapman; Tracy Hulderman; Nico van Rooijen; Petia P Simeonova
Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(6):R1488-95.
2006: Smriti Agrawal; Per Anderson; Madeleine Durbeej; Nico van Rooijen; Fredrik Ivars; Ghislain Opdenakker; Lydia Sorokin
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2006;203(4):1007-19.
2006: Serban Morosan; Stéphanie Hez-Deroubaix; Françoise Lunel; Laurent Renia; Carlo Giannini; Nico van Rooijen; Serena Battaglia; Catherine Blanc; Wijnand Eling; Robert W Sauerwein; Laurent Hannoun; Jacques Belghiti; Christian Brechot; Dina Kremsdorf; Pierre Druilhe
Liver-stage development of Plasmodium falciparum, in a humanized mouse model.
The Journal of infectious diseases 2006;193(7):996-1004.
2006: Frank Tacke; Ginhoux Florent; Claudia Jakubzick; Nico van Rooijen; Miriam Merad; Gwendalyn J Randolph
Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery.
The Journal of experimental medicine 2006;203(3):583-97.
2006: Claudia Jakubzick; Frank Tacke; Jaime Llodra; Nico van Rooijen; Gwendalyn J Randolph
Modulation of dendritic cell trafficking to and from the airways.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3578-84.
2006: Stephan Gehring; Elizabeth M Dickson; Maryann E San Martin; Nico van Rooijen; Elaine F Papa; Mark W Harty; Thomas F Tracy; Stephen H Gregory
Kupffer cells abrogate cholestatic liver injury in mice.
Gastroenterology 2006;130(3):810-22.
2006: Alicia Moreno; Elizabeth Ferrer; Susana Arahuetes; Cesar Eguiluz; Nico van Rooijen; Agustin Benito
The course of infections and pathology in immunomodulated NOD/LtSz-SCID mice inoculated with Plasmodium falciparum laboratory lines and clinical isolates.
International journal for parasitology 2006;36(3):361-9.
2006: Marie Le Borgne; Nathalie Etchart; Anne Goubier; sergio lira; Jean-Claude Sirard; Nico van Rooijen; Christophe Caux; Smina Aït-Yahia; Alain P Vicari; Dominique Kaiserlian; Bertrand Dubois
Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.
Immunity 2006;24(2):191-201.
2006: Josée Golay; Elena Cittera; Nicola Di Gaetano; Massimiliano Manganini; Michela Mosca; Manuela Nebuloni; Nico van Rooijen; Luca Vago; Martino Introna
The role of complement in the therapeutic activity of rituximab in a murine B lymphoma model homing in lymph nodes.
Haematologica 2006;91(2):176-83.
2006: Maria G Frid; Jacqueline A Brunetti; Danielle L Burke; Todd C Carpenter; Neil J Davie; John T Reeves; Mark T Roedersheimer; Nico van Rooijen; Kurt R Stenmark
Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage.
The American journal of pathology 2006;168(2):659-69.
2006: Ashraful Haque; Anna Easton; Debbie Smith; Anne O'Garra; Nico van Rooijen; Ganjana Lertmemongkolchai; Richard Titball; Gregory J Bancroft
Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection.
The Journal of infectious diseases 2006;193(3):370-9.
2006: Krystal J Evans; Diana Hansen; Nico van Rooijen; Lynn Buckingham; Louis Schofield
Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes.
Blood 2006;107(3):1192-9.
2006: Christopher K Cote; Nico van Rooijen; Susan L Welkos
Roles of macrophages and neutrophils in the early host response to Bacillus anthracis spores in a mouse model of infection.
Infection and immunity 2006;74(1):469-80.
2006: Niamh E Mangan; Nico van Rooijen; Andrew N J McKenzie; Padraic G Fallon
Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):138-47.
2005: Melanie Keller; Alexander L Gerbes; Stefanie Kulhanek-Heinze; Tobias Gerwig; Uwe Grutzner; Nico van Rooijen; Angelika M Vollmar; Alexandra K Kiemer
Hepatocyte cytoskeleton during ischemia and reperfusion--influence of ANP-mediated p38 MAPK activation.
World journal of gastroenterology : WJG 2005;11(47):7418-29.
2005: Kate E Lawlor; Peter K K Wong; Ian K Campbell; Nico van Rooijen; Ian P Wicks
Acute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4, joint macrophages, granulocyte-macrophage colony-stimulating factor, interleukin-6, and leukemia inhibitory factor.
Arthritis and rheumatism 2005;52(12):3749-54.
2005: Terrence M Tumpey; Adolfo García-Sastre; Jeffery Taubenberger; Peter Palese; David E Swayne; Mary J Pantin-Jackwood; Stacey Schultz-Cherry; Alicia Solórzano; Nico van Rooijen; Jacqueline M Katz; Christopher F Basler
Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice.
Journal of virology 2005;79(23):14933-44.
2005: Markus Höltje; Anja Hoffmann; Franz Hofmann; Christian Mucke; Gisela Grosse; Nico van Rooijen; Helmut Kettenmann; Ingo Just; Gudrun Ahnert-Hilger
Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing.
Journal of neurochemistry 2005;95(5):1237-48.
2005: Richard P Ciavarra; Lisa Taylor; Amy R Greene; Nazita Yousefieh; Dale Horeth; Nico van Rooijen; Christina Steel; Betsy Gregory; Mark Birkenbach; Margaret Sekellick
Impact of macrophage and dendritic cell subset elimination on antiviral immunity, viral clearance and production of type 1 interferon.
Virology 2005;342(2):177-89.
2005: Janine Ezendam; Kevin Kosterman; Henneke Spijkerboer; Rob Bleumink; Ine Hassing; Nico van Rooijen; Joseph G Vos; Raymond Pieters
Macrophages are involved in hexachlorobenzene-induced adverse immune effects.
Toxicology and applied pharmacology 2005;209(1):19-27.
2005: Steven J Oosterling; Gerben J van der Bij; Gerrit A Meijer; Cornelis W Tuk; Evert van Garderen; Nico van Rooijen; Sybren Meijer; J R M van der Sijp; Robert H J Beelen; Marjolein van Egmond
Macrophages direct tumour histology and clinical outcome in a colon cancer model.
The Journal of pathology 2005;207(2):147-55.
2005: Matthias Kresse; Markus Latta; Gerald Künstle; Hans-Martin Riehle; Nico van Rooijen; Hannes Hentze; Gisa Tiegs; Markus Biburger; Rudolf Lucas; Albrecht Wendel
Kupffer cell-expressed membrane-bound TNF mediates melphalan hepatotoxicity via activation of both TNF receptors.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):4076-83.
2005: Kazuichi Maruyama; Masaaki Ii; Claus Cursiefen; David G Jackson; Hiroshi Keino; Minoru Tomita; Nico van Rooijen; Hideya Takenaka; Patricia A D'Amore; Joan Stein-Streilein; Douglas Losordo; J Wayne Streilein
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages.
The Journal of clinical investigation 2005;115(9):2363-72.
2005: Xiuping Shao; Aron Mednick; Mauricio Alvarez; Nico van Rooijen; Arturo Casadevall; David Goldman
An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3244-51.
2005: Tracey A Newman; Ian Galea; Nico van Rooijen; V Hugh Perry
Blood-derived dendritic cells in an acute brain injury.
Journal of neuroimmunology 2005;166(1-2):167-72.
2005: Sumia Ali; Gwendalyn D King; James F Curtin; Marianela Candolfi; Weidong Xiong; Chunyan Liu; Mariana Puntel; Queng Cheng; Jesus Prieto; Antoni Ribas; Jerzy W Kupiec-Weglinski; Nico van Rooijen; Hans Lassmann; Pedro R Lowenstein; Maria G Castro
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
Cancer research 2005;65(16):7194-204.
2005: Todd Machemer; Heidrun Engler; Van Tsai; Seoju Lee; Susan Cannon-Carlson; Marcio Voloch; Thomas Schluep; Sundari Ravindran; Gary Vellekamp; Elena Brin; Douglas Cornell; Suganto Sutjipto; Shu Fen Wen; Mark Horn; Nico van Rooijen; Daniel Maneval; Beth Hutchins; Drake LaFace
Characterization of hemodynamic events following intravascular infusion of recombinant adenovirus reveals possible solutions for mitigating cardiovascular responses.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):254-63.
2005: Stefan Nierkens; Rob Bleumink; Marianne Bol; Ine Hassing; Nico van Rooijen; Raymond Pieters
The reactive D-glucopyranose moiety of streptozotocin is responsible for activation of macrophages and subsequent stimulation of CD8+ T cells.
Chemical research in toxicology 2005;18(5):872-9.
2005: Dan-Qing Lou; Jeanne-Claire Lesbordes; Gaël Nicolas; Lydie Viatte; Myriam Bennoun; Nico van Rooijen; Axel Kahn; Laurent Renia; Sophie Vaulont
Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo.
Hepatology (Baltimore, Md.) 2005;41(5):1056-64.
2005: Svetlana Stamatovic; Parvin Shakui; Richard F Keep; Bethany B Moore; Steven Kunkel; Nico van Rooijen; Anuska A Zochowska
Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(5):593-606.
2005: Abderrahim Nemmar; Benoit Nemery; Peter H M Hoet; Nico van Rooijen; Marc F Hoylaerts
Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross-talk.
American journal of respiratory and critical care medicine 2005;171(8):872-9.
2005: Atsuki Fukushima; Akemi Ozaki; Waka Ishida; Nico van Rooijen; Kazuyo Fukata; Hisayuki Ueno
Suppression of macrophage infiltration into the conjunctiva by clodronate liposomes in experimental immune-mediated blepharoconjunctivitis.
Cell biology international 2005;29(4):277-86.
2005: Tatjana Nikolic; Sacha Geutskens; Nico van Rooijen; Hemmo Drexhage; Pieter J M Leenen
Dendritic cells and macrophages are essential for the retention of lymphocytes in (peri)-insulitis of the nonobese diabetic mouse: a phagocyte depletion study.
Laboratory investigation; a journal of technical methods and pathology 2005;85(4):487-501.
2005: Julia Skokowa; Syed R Ali; Olga Felda; Varsha Kumar; Stephanie Konrad; Nelli Shushakova; Reinhold E Schmidt; Roland P Piekorz; Bernd Nürnberg; Karsten Spicher; Lutz Birnbaumer; Jörg Zwirner; Jill W C Claassens; Sjef Verbeek; Nico van Rooijen; Jörg Köhl; J Engelbert Gessner
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):3041-50.
2005: Andreas Geier; Gernot Zollner; Christoph G Dietrich; Martin Wagner; Peter Fickert; Helmut Denk; Nico van Rooijen; Siegfried Matern; Carsten Gartung; Michael Trauner
Cytokine-independent repression of rodent Ntcp in obstructive cholestasis.
Hepatology (Baltimore, Md.) 2005;41(3):470-7.
2005: Manolo Rodrigo Garzón; Pedro Berraondo; Julien Crettaz; Laura Ochoa; Maria Vera; Juan José Lasarte; Africa Vales; Nico van Rooijen; Juan Ruiz; Jesús Prieto; Javier J Zulueta; Gloria González-Aseguinolaza
Induction of gp120-specific protective immune responses by genetic vaccination with linear polyethylenimine-plasmid complex.
Vaccine 2005;23(11):1384-92.
2005: Mark R Kotter; Chao Zhao; Nico van Rooijen; Robin J M Franklin
Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression.
Neurobiology of disease 2005;18(1):166-75.
2005: Ian Galea; Karine Palin; Tracey A Newman; Nico van Rooijen; V Hugh Perry; Delphine Boche
Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain.
Glia 2005;49(3):375-84.
2005: John Schmieg; Guangli Yang; Richard W Franck; Nico van Rooijen; Moriya Tsuji
Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(4):1127-32.
2005: Oscar D Bustuoabad; Raúl A Ruggiero; Pedro D di Gianni; M Gabriela Lombardi; Carolina Belli; Gabriela Verónica Camerano; Graciela I Dran; Carolina Schere-Levy; Héctor Costa; Martín A Isturiz; Marina Narvaitz; Nico van Rooijen; Victoria de los A Bustuoabad; Roberto Meiss
Tumor transition zone: a putative new morphological and functional hallmark of tumor aggressiveness.
Oncology research 2005;15(3):169-82.
2005: Ekkehard Sturm; Rick Havinga; Julius F W Baller; Henk Wolters; Nico van Rooijen; Jan A A M Kamps; Henkjan J Verkade; Saul J Karpen; Folkert Kuipers
Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats.
Journal of hepatology 2005;42(1):102-9.
2005: María Virginia Tribulatti; Juan Mucci; Nico van Rooijen; María Susana Leguizamón; Oscar Campetella
The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents.
Infection and immunity 2005;73(1):201-7.
2005: Jaklien C Leemans; Theo Thepen; Sebastiaan Weijer; Sandrine Florquin; Nico van Rooijen; Jan G J van de Winkel; Tom van der Poll
Macrophages play a dual role during pulmonary tuberculosis in mice.
The Journal of infectious diseases 2005;191(1):65-74.
2005: Alicia Moreno Sabater; Marta Moreno; Francisco Javier Moreno; Cesar Eguiluz; Nico van Rooijen; Agustin Benito
Experimental infection of immunomodulated NOD/LtSz-SCID mice as a new model for Plasmodium falciparum erythrocytic stages.
Parasitology research 2005;95(2):97-105.
2004: Chunfeng Qu; Emmerson W Edwards; Frank Tacke; Véronique Angeli; Jaime Llodrá; Guzman Sanchez-Schmitz; Alexandre Garin; Nasreen Haque; Wendy Peters; Nico van Rooijen; Carmen Sanchez-Torres; Jonathan Bromberg; Israel F Charo; Steffen Jung; sergio lira; Gwendalyn J Randolph
Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes.
The Journal of experimental medicine 2004;200(10):1231-41.
2004: Niamh E Mangan; Rosie E Fallon; Philip Smith; Nico van Rooijen; Andrew N J McKenzie; Padraic G Fallon
Helminth infection protects mice from anaphylaxis via IL-10-producing B cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6346-56.
2004: Christopher K Cote; Kelly M Rea; Sarah L Norris; Nico van Rooijen; Susan L Welkos
The use of a model of in vivo macrophage depletion to study the role of macrophages during infection with Bacillus anthracis spores.
Microbial pathogenesis 2004;37(4):169-75.
2004: Zhilong Jiang; Gudrun Schiedner; Nico van Rooijen; Chau-Ching Liu; Stefan Kochanek; Paula R Clemens
Sustained muscle expression of dystrophin from a high-capacity adenoviral vector with systemic gene transfer of T cell costimulatory blockade.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(4):688-96.
2004: Jeanne Godau; Tanja Heller; Heiko Hawlisch; Matthew Trappe; Elaine Howells; Jennifer Best; Jörg Zwirner; Sjef Verbeek; P Mark Hogarth; Craig Gerard; Nico van Rooijen; Andreas Klos; J Engelbert Gessner; Jörg Köhl
C5a initiates the inflammatory cascade in immune complex peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3437-45.
2004: Arjen B Blom; P L E M van Lent; A E M Holthuysen; Peter van der Kraan; Johannes Roth; Nico van Rooijen; Wim B van den Berg
Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(8):627-35.
2004: Leanne M Sammels; Erika Bosio; Clayton T Fragall; Miranda D Grounds; Nico van Rooijen; Ian Lee
Innate inflammatory cells are not responsible for early death of donor myoblasts after myoblast transfer therapy.
Transplantation 2004;77(12):1790-7.
2004: Tanja P A M Slegers; Lidy Broersma; Nico van Rooijen; Johanna M M Hooymans; Gabriel van Rij; Ruth van der Gaag
Macrophages play a role in the early phase of corneal allograft rejection in rats.
Transplantation 2004;77(11):1641-6.
2004: Hongwei Gao; Ren-Feng Guo; Cecilia L Speyer; Jayne S Reuben; Thomas A Neff; Laszlo M Hoesel; Niels C Riedemann; Shannon D McClintock; J Vidya Sarma; Nico van Rooijen; Firas S Zetoune; Peter A Ward
Stat3 activation in acute lung injury.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7703-12.
2004: Ann M Lee; Allison Fryer; Nico van Rooijen; David B Jacoby
Role of macrophages in virus-induced airway hyperresponsiveness and neuronal M2 muscarinic receptor dysfunction.
American journal of physiology. Lung cellular and molecular physiology 2004;286(6):L1255-9.
2004: Edward H Hughes; Frank C Schlichtenbrede; Conor C Murphy; Cathryn Broderick; Nico van Rooijen; Robin R Ali; Andrew D Dick
Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism.
Experimental eye research 2004;78(6):1077-84.
2004: Randal A Wolff; Jeffrey J Tomas; Debra A Hullett; V Emily Stark; Nico van Rooijen; John R Hoch
Macrophage depletion reduces monocyte chemotactic protein-1 and transforming growth factor-beta1 in healing rat vein grafts.
Journal of vascular surgery 2004;39(4):878-88.
2004: Douglas A Drevets; Marilyn J Dillon; Jennifer S Schawang; Nico van Rooijen; Jan Ehrchen; Cord Sunderkötter; Pieter J M Leenen
The Ly-6Chigh monocyte subpopulation transports Listeria monocytogenes into the brain during systemic infection of mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(7):4418-24.
2004: Cord Sunderkötter; Tatjana Nikolic; Marilyn J Dillon; Nico van Rooijen; Martin Stehling; Douglas A Drevets; Pieter J M Leenen
Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(7):4410-7.
2004: Grace C Silva; Patrícia R A Nagib; Egler Chiari; Nico van Rooijen; Conceição R S Machado; Elizabeth R S Camargos
Peripheral macrophage depletion reduces central nervous system parasitism and damage in Trypanosoma cruzi-infected suckling rats.
Journal of neuroimmunology 2004;149(1-2):50-8.
2004: Marek Jasinski; Panagiotis Pantazopoulos; Russell P Rother; Nico van Rooijen; Wen-Chao Song; Hector Molina; Monica Bessler
A novel mechanism of complement-independent clearance of red cells deficient in glycosyl phosphatidylinositol-linked proteins.
Blood 2004;103(7):2827-34.
2004: Katrin A Mühlen; Jens Schümann; Frederick Wittke; Steffen Stenger; Nico van Rooijen; Luc Van Kaer; Gisa Tiegs
NK cells, but not NKT cells, are involved in Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):3034-41.
2004: José L Marín-Teva; Isabelle Dusart; Catherine Colin; Annie Gervais; Nico van Rooijen; Michel Mallat
Microglia promote the death of developing Purkinje cells.
Neuron 2004;41(4):535-47.
2004: Magdalena Chadzinska; Elzbieta Kolaczkowska; Anna Scislowska-Czarnecka; Nico van Rooijen; Barbara Plytycz
Effects of macrophage depletion on peritoneal inflammation in swiss mice, edible frogs and goldfish.
Folia biologica 2004;52(3-4):225-31.
2004: Veronica I Landoni; M Vermeulen; Nico van Rooijen; S Gómez; Marina S Palermo; Martín A Isturiz; Fernanda Alves-Rosa
Macrophage derived signalling regulates negatively the megakaryocyte compartment.
Cellular and molecular biology (Noisy-le-Grand, France) 2004;50 Online Pub():OL667-75.
2004: P L E M van Lent; Arjen B Blom; Peter van der Kraan; A E M Holthuysen; Elly L Vitters; Nico van Rooijen; Ruben L Smeets; K C A M Nabbe; Wim B van den Berg
Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation.
Arthritis and rheumatism 2004;50(1):103-11.
2003: jeroen saeij; Adrie Groeneveld; Nico van Rooijen; Olga L M Haenen; Geert F Wiegertjes
Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates.
Diseases of aquatic organisms 2003;57(1-2):67-75.
2003: Gudrun Schiedner; Wilhelm Bloch; Sabine Hertel; Marion Johnston; Andrei Molojavyi; Volker Dries; Georg Varga; Nico van Rooijen; Stefan Kochanek
A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells.
Human gene therapy 2003;14(17):1631-41.
2003: Matthew D Jose; Yohei Ikezumi; Nico van Rooijen; Robert C Atkins; Steven J Chadban
Macrophages act as effectors of tissue damage in acute renal allograft rejection.
Transplantation 2003;76(7):1015-22.
2003: Masashi Emoto; Mamiko Miyamoto; Yoshiko Emoto; Izumi Yoshizawa; Volker Brinkmann; Nico van Rooijen; Stefan H E Kaufmann
Highly biased type 1 immune responses in mice deficient in LFA-1 in Listeria monocytogenes infection are caused by elevated IL-12 production by granulocytes.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):3970-6.
2003: Nadeem A Sheikh; George S Attard; Nico van Rooijen; Palasingam Rajananthanan; Kandasamy Hariharan; Ya-Wun Yang; W John W Morrow
Differential requirements for CTL generation by novel immunostimulants: APC tropism, use of the TAP-independent processing pathway, and dependency on CD80/CD86 costimulation.
Vaccine 2003;21(25-26):3775-88.
2003: Martijn A Nolte; Jeroen A M Beliën; Inge L Schadee-Eestermans; Wendy Jansen; wendy unger; Nico van Rooijen; Georg Kraal; Reina E Mebius
A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp.
The Journal of experimental medicine 2003;198(3):505-12.
2003: Phillip Popovich; Nico van Rooijen; William F Hickey; Geoff Preidis; Violeta M McGaughy
Hematogenous macrophages express CD8 and distribute to regions of lesion cavitation after spinal cord injury.
Experimental neurology 2003;182(2):275-87.
2003: Eiji Sakurai; Akshay Anand; Balamurali K Ambati; Nico van Rooijen; Jayakrishna Ambati
Macrophage depletion inhibits experimental choroidal neovascularization.
Investigative ophthalmology & visual science 2003;44(8):3578-85.
2003: Masashi Emoto; Yoshiko Emoto; Volker Brinkmann; Mamiko Miyamoto; Izumi Yoshizawa; Manuela Stäber; Nico van Rooijen; Alf Hamann; Stefan H E Kaufmann
Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):584-93.
2003: Babu V Naidu; Baiya Krishnadasan; Alexander S Farivar; Steven M Woolley; Robert Thomas; Nico van Rooijen; Edward D Verrier; Michael S Mulligan
Early activation of the alveolar macrophage is critical to the development of lung ischemia-reperfusion injury.
The Journal of thoracic and cardiovascular surgery 2003;126(1):200-7.
2003: Elodie Belnoue; Fabio T M Costa; Ana Margarida Vigário; Tatiana Voza; Françoise Gonnet; Irène Landau; Nico van Rooijen; Matthias Mack; William Kuziel; Laurent Rénia
Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria.
Infection and immunity 2003;71(6):3648-51.
2003: Sharon A McClellan; Xi Huang; Ronald Barrett; Nico van Rooijen; Linda D Hazlett
Macrophages restrict Pseudomonas aeruginosa growth, regulate polymorphonuclear neutrophil influx, and balance pro- and anti-inflammatory cytokines in BALB/c mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):5219-27.
2003: Tanja P A M Slegers; Gerard van der Veen; L Joep A Hermans; Lidy Broersma; Nico van Rooijen; Hennie J Völker-Dieben; Gabriel van Rij; Ruth van der Gaag
Adhesion molecule expression in local-macrophage-depleted rats bearing orthotopic corneal allografts.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2003;241(5):432-8.
2003: Abdulkadir Omer; Mitchell Keegan; Eva Czismadia; Paul De Vos; Nico van Rooijen; Susan Bonner-Weir; Gordon C Weir
Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats.
Xenotransplantation 2003;10(3):240-51.
2003: Guosheng Wu; Olle Korsgren; Shibo Sun; Nico van Rooijen; Annika Tibell
Effect of plasma exchange in combination with deoxyspergualin on the survival of guinea-pig hearts in macrophage-depleted C6-deficient rats.
Xenotransplantation 2003;10(3):214-22.
2003: Christelle Rivas; Aouatef Djeraba; Eugène Musset; Nico van Rooijen; Bas Baaten; Pascale Quéré
Intravenous treatment with liposome-encapsulated dichloromethylene bisphosphonate (Cl2MBP) suppresses nitric oxide production and reduces genetic resistance to Marek's disease.
Avian pathology : journal of the W.V.P.A 2003;32(2):139-49.
2003: Fernanda Alves-Rosa; Mónica Vermeulen; Juana Cabrera; Carmen Stanganelli; Alejandra Capozzo; Marina Narbaitz; Nico van Rooijen; Marina S Palermo; Martín A Isturiz
Macrophage depletion following liposomal-encapsulated clodronate (LIP-CLOD) injection enhances megakaryocytopoietic and thrombopoietic activities in mice.
British journal of haematology 2003;121(1):130-8.
2003: Agnieszka Masztalerz; Nico van Rooijen; Willem Den Otter; Linda A Everse
Mechanisms of macrophage cytotoxicity in IL-2 and IL-12 mediated tumour regression.
Cancer immunology, immunotherapy : CII 2003;52(4):235-42.
2003: Brendan C Dickson; Hua Yang; Huub F J Savelkoul; Geoff Rowden; Nico van Rooijen; James R Wright
Islet transplantation in the discordant tilapia-to-mouse model: a novel application of alginate microencapsulation in the study of xenograft rejection.
Transplantation 2003;75(5):599-606.
2003: Nazia Selzner; Markus Selzner; Bernhard Odermatt; Yinghua Tian; Nico van Rooijen; Pierre-Alain Clavien
ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice.
Gastroenterology 2003;124(3):692-700.
2003: Shounan Yi; Wayne J Hawthorne; Anne M Lehnert; Hong Ha; Jeffrey K W Wong; Nico van Rooijen; Kelly Davey; Anita T Patel; Stacey N Walters; Abhilash Chandra; Philip J O'Connell
T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2750-8.
2003: Marinee K L Chuah; Gudrun Schiedner; Lieven Thorrez; Brian Brown; Marion Johnston; Veerle Gillijns; Sabine Hertel; Nico van Rooijen; David Lillicrap; Désiré Collen; Thierry VandenDriessche; Stefan Kochanek
Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors.
Blood 2003;101(5):1734-43.
2003: Tanja P A M Slegers; Ruth van der Gaag; Nico van Rooijen; Gabriel van Rij; J Wayne Streilein
Effect of local macrophage depletion on cellular immunity and tolerance evoked by corneal allografts.
Current eye research 2003;26(2):73-9.
2003: Sylvia Knapp; Jaklien C Leemans; Sandrine Florquin; Judith Branger; Nico A Maris; Jennie M Pater; Nico van Rooijen; Tom van der Poll
Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia.
American journal of respiratory and critical care medicine 2003;167(2):171-9.
2003: Michael B Jordan; Nico van Rooijen; Shozo Izui; John Kappler; Philippa Marrack
Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model.
Blood 2003;101(2):594-601.
2003: Nico van Rooijen; Esther van Kesteren-Hendrikx
"In vivo" depletion of macrophages by liposome-mediated "suicide".
Methods in enzymology 2003;373():3-16.
2003: Gudrun Schiedner; Sabine Hertel; Marion Johnston; Volker Dries; Nico van Rooijen; Stefan Kochanek
Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(1):35-43.
2002: Elodie Belnoue; Michèle Kayibanda; Ana M Vigario; Jean-Christophe Deschemin; Nico van Rooijen; Mireille Viguier; Georges Snounou; Laurent Rénia
On the pathogenic role of brain-sequestered alphabeta CD8+ T cells in experimental cerebral malaria.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6369-75.
2002: Lisa M Sedger; Sam Hou; Sarah R Osvath; Moira Glaccum; Jacques J Peschon; Nico van Rooijen; Lisa Hyland
Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6193-201.
2002: Eirunn Knudsen; Per Ole Iversen; Nico van Rooijen; Haakon B Benestad
Macrophage-dependent regulation of neutrophil mobilization and chemotaxis during development of sterile peritonitis in the rat.
European journal of haematology 2002;69(5-6):284-96.
2002: Helene A Haeberle; Ryuta Takizawa; Antonella Casola; allan brasier; Hans-Juergen Dieterich; Nico van Rooijen; Zoran Gatalica; Roberto P Garofalo
Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways.
The Journal of infectious diseases 2002;186(9):1199-206.
2002: Odilia L C Wijburg; Nico van Rooijen; Richard A Strugnell
Induction of CD8+ T lymphocytes by Salmonella typhimurium is independent of Salmonella pathogenicity island 1-mediated host cell death.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3275-83.
2002: Dirk Bauer; Andreas Schmitz; Nico van Rooijen; Klaus-Peter Steuhl; Arnd Heiligenhaus
Conjunctival macrophage-mediated influence of the local and systemic immune response after corneal herpes simplex virus-1 infection.
Immunology 2002;107(1):118-28.
2002: John Marshall; Kerry Anne McEachern; Julie A Cavanagh Kyros; Jennifer B Nietupski; Tracey Budzinski; Robin J Ziegler; Nelson S Yew; Jennifer Sullivan; Abraham Scaria; Nico van Rooijen; John A Barranger; Seng Cheng
Demonstration of feasibility of in vivo gene therapy for Gaucher disease using a chemically induced mouse model.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(2):179-89.
2002: Ren-Feng Guo; Alex B Lentsch; J Vidya Sarma; Lei Sun; Niels C Riedemann; Shannon D McClintock; Stephanie R McGuire; Nico van Rooijen; Peter A Ward
Activator protein-1 activation in acute lung injury.
The American journal of pathology 2002;161(1):275-82.
2002: Robin J Ziegler; Chester Li; Maribeth Cherry; Yunxiang Zhu; Donna Hempel; Nico van Rooijen; Yiannis A Ioannou; Robert J Desnick; Mark A Goldberg; Nelson S Yew; Seng Cheng
Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease.
Human gene therapy 2002;13(8):935-45.
2002: Aouatef Djeraba; Eugène Musset; Nico van Rooijen; Pascale Quéré
Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance.
Veterinary microbiology 2002;86(3):229-44.
2002: Elzbieta Kolaczkowska; Susan Shahzidi; Rolf Seljelid; Nico van Rooijen; Barbara Plytycz
Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes.
Inflammation 2002;26(2):61-71.
2002: Nico van Rooijen; Esther van Kesteren-Hendrikx
Clodronate liposomes: perspectives in research and therapeutics.
Journal of liposome research 2002;12(1-2):81-94.
2002: Fernanda Alves-Rosa; Carmen Stanganelli; Juana Cabrera; Dora Cymberknop; Carolina Rubel; Silvia Vanzulli; Nico van Rooijen; Marina S Palermo; Martín A Isturiz
Rapid recovery of platelet count following administration of liposome-encapsulated clodronate in a mouse model of immune thrombocytopenia.
British journal of haematology 2002;116(2):357-66.
2002: Tammy Kielian; Nico van Rooijen; William F Hickey
MCP-1 expression in CNS-1 astrocytoma cells: implications for macrophage infiltration into tumors in vivo.
Journal of neuro-oncology 2002;56(1):1-12.
2002: Machteld M J Polfliet; Frank van de Veerdonk; Ed A Döpp; Esther van Kesteren-Hendrikx; Nico van Rooijen; Christine D Dijkstra; Timo K van den Berg
The role of perivascular and meningeal macrophages in experimental allergic encephalomyelitis.
Journal of neuroimmunology 2002;122(1-2):1-8.
2002: Stephen H Gregory; Leslie P Cousens; Nico van Rooijen; Ed A Döpp; Timothy M Carlos; Edward J Wing
Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):308-15.
2001: Guosheng Wu; Olle Korsgren; Nico van Rooijen; Annika Tibell
Suppression of T cells results in long-term survival of mouse heart xenografts in C6-deficient rats.
Xenotransplantation 2001;8(4):303-9.
2001: Machteld M J Polfliet; Petra J G Zwijnenburg; A Marceline van Furth; Tom van der Poll; Ed A Döpp; Chantal Renardel de Lavalette; Esther van Kesteren-Hendrikx; Nico van Rooijen; Christine D Dijkstra; Timo K van den Berg
Meningeal and perivascular macrophages of the central nervous system play a protective role during bacterial meningitis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4644-50.
2001: Mark R Kotter; Anna Setzu; Fraser J Sim; Nico van Rooijen; Robin J M Franklin
Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination.
Glia 2001;35(3):204-12.
2001: Peter Laverman; M G Carstens; Otto Boerman; Els Th M Dams; Wim J G Oyen; Nico van Rooijen; Frans H M Corstens; Gert Storm
Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection.
The Journal of pharmacology and experimental therapeutics 2001;298(2):607-12.
2001: Machteld M J Polfliet; Peter H Goede; Esther van Kesteren-Hendrikx; Nico van Rooijen; Christine D Dijkstra; Timo K van den Berg
A method for the selective depletion of perivascular and meningeal macrophages in the central nervous system.
Journal of neuroimmunology 2001;116(2):188-95.
2001: Alberto Moreno; Edgar Badell; Nico van Rooijen; Pierre Druilhe
Human malaria in immunocompromised mice: new in vivo model for chemotherapy studies.
Antimicrobial agents and chemotherapy 2001;45(6):1847-53.
2001: Laurent Salez; Viviane Balloy; Nico van Rooijen; Mai Lebastard; Lhousseine Touqui; Francis X McCormack; Michel Chignard
Surfactant protein A suppresses lipopolysaccharide-induced IL-10 production by murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6376-82.
2001: Cécile Guillot; H Coathalem; J Chetritt; A David; Pedro R Lowenstein; E Gilbert; Laurent Tesson; Nico van Rooijen; Maria Cristina Cuturi; Jean-Paul Soulillou; Ignacio Anegon
Lethal hepatitis after gene transfer of IL-4 in the liver is independent of immune responses and dependent on apoptosis of hepatocytes: a rodent model of IL-4-induced hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5225-35.
2001: Jaklien C Leemans; Nicole P Juffermans; Sandrine Florquin; Nico van Rooijen; Margriet J Vervoordeldonk; Annelies Verbon; Sander J H van Deventer; Tom van der Poll
Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4604-11.
2001: Dirk Bauer; S Mrzyk; Nico van Rooijen; Klaus-Peter Steuhl; Arnd Heiligenhaus
Incidence and severity of herpetic stromal keratitis: impaired by the depletion of lymph node macrophages.
Experimental eye research 2001;72(3):261-9.
2001: M D Lehner; J Ittner; Daniela S Bundschuh; Nico van Rooijen; Albrecht Wendel; Thomas Hartung
Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response.
Infection and immunity 2001;69(1):463-71.
2000: Edgar Badell; Claude Oeuvray; Alberto Moreno; Soe Soe; Nico van Rooijen; Ahmed Bouzidi; Pierre Druilhe
Human malaria in immunocompromised mice: an in vivo model to study defense mechanisms against Plasmodium falciparum.
The Journal of experimental medicine 2000;192(11):1653-60.
2000: Richard P Ciavarra; A R Greene; D R Horeth; K Buhrer; Nico van Rooijen; B Tedeschi
Antigen processing of vesicular stomatitis virus in situ. Interdigitating dendritic cells present viral antigens independent of marginal dendritic cells but fail to prime CD4(+) and CD8(+) T cells.
Immunology 2000;101(4):512-20.
2000: Jens Schümann; D Wolf; A Pahl; K Brune; Thomas Papadopoulos; Nico van Rooijen; Gisa Tiegs
Importance of Kupffer cells for T-cell-dependent liver injury in mice.
The American journal of pathology 2000;157(5):1671-83.
2000: Fernanda Alves-Rosa; Carmen Stanganelli; Juana Cabrera; Nico van Rooijen; Marina S Palermo; Martín A Isturiz
Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune thrombocytopenic purpura in a mouse model.
Blood 2000;96(8):2834-40.
2000: Masashi Emoto; Mamiko Miyamoto; K Namba; R Schmits; Nico van Rooijen; Eiji Kita; Stefan H E Kaufmann
Participation of leukocyte function-associated antigen-1 and NK cells in the homing of thymic CD8+NKT cells to the liver.
European journal of immunology 2000;30(10):3049-56.
2000: Mamiko Miyamoto; Masashi Emoto; Volker Brinkmann; Nico van Rooijen; R Schmits; Eiji Kita; Stefan H E Kaufmann
Cutting edge: contribution of NK cells to the homing of thymic CD4+NKT cells to the liver.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1729-32.
2000: Guosheng Wu; Olle Korsgren; J Zhang; Z Song; Nico van Rooijen; Annika Tibell
Pig islet xenograft rejection is markedly delayed in macrophage-depleted mice: a study in streptozotocin diabetic animals.
Xenotransplantation 2000;7(3):214-20.
2000: Guosheng S Wu; Olle Korsgren; J G Zhang; Z S Song; Nico van Rooijen; Annika Tibell
Role of macrophages and natural killer cells in the rejection of pig islet xenografts in mice.
Transplantation proceedings 2000;32(5):1069.
2000: Tanja P A M Slegers; PF Torres; Lidy Broersma; Nico van Rooijen; Gabriel van Rij; Ruth van der Gaag
Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in rats.
Investigative ophthalmology & visual science 2000;41(8):2239-47.
2000: Peter Laverman; Adrienne H Brouwers; Els Th M Dams; Wim J G Oyen; Gert Storm; Nico van Rooijen; Frans H M Corstens; Otto Boerman
Preclinical and clinical evidence for disappearance of long-circulating characteristics of polyethylene glycol liposomes at low lipid dose.
The Journal of pharmacology and experimental therapeutics 2000;293(3):996-1001.
2000: Tanja P A M Slegers; Nico van Rooijen; Gabriel van Rij; Ruth van der Gaag
Delayed graft rejection in pre-vascularised corneas after subconjunctival injection of clodronate liposomes.
Current eye research 2000;20(4):322-4.
2000: Odilia L C Wijburg; Cameron P Simmons; Nico van Rooijen; Richard A Strugnell
Dual role for macrophages in vivo in pathogenesis and control of murine Salmonella enterica var. Typhimurium infections.
European journal of immunology 2000;30(3):944-53.
2000: Catharina Meijer; Marinus J Wiezer; A M Diehl; H J Schouten; H J Schouten; Sybren Meijer; Nico van Rooijen; Anton A van Lambalgen; Christine D Dijkstra; Paul A M van Leeuwen
Kupffer cell depletion by CI2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy.
Liver 2000;20(1):66-77.
2000: R Westerhuis; S C van Straaten; Mieneke G A van Dixhoorn; Nico van Rooijen; Nicole A M Verhagen; C D Dijkstra; Emile de Heer; Mohamed R Daha
Distinctive roles of neutrophils and monocytes in anti-thy-1 nephritis.
The American journal of pathology 2000;156(1):303-10.
2000: Dirk Bauer; S Mrzyk; Nico van Rooijen; Klaus-Peter Steuhl; Arnd Heiligenhaus
Macrophage-depletion influences the course of murine HSV-1 keratitis.
Current eye research 2000;20(1):45-53.
1999: PF Torres; Tanja P A M Slegers; Ron Peek; Nico van Rooijen; Ruth van der Gaag; Aize Kijlstra; AF de Vos
Changes in cytokine mRNA levels in experimental corneal allografts after local clodronate-liposome treatment.
Investigative ophthalmology & visual science 1999;40(13):3194-201.
1999: Guosheng Wu; Olle Korsgren; Nico van Rooijen; Lars Wennberg; Annika Tibell
The effect of macrophage depletion on delayed xenograft rejection: studies in the guinea pig-to-C6-deficient rat heart transplantation model.
Xenotransplantation 1999;6(4):262-70.
1999: John R Hoch; VK Stark; Nico van Rooijen; J L Kim; M P Nutt; Thomas F Warner
Macrophage depletion alters vein graft intimal hyperplasia.
Surgery 1999;126(2):428-37.
1999: Phillip Popovich; Zhen Guan; Ping Wei; I Huitinga; Nico van Rooijen; Bradford T Stokes
Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury.
Experimental neurology 1999;158(2):351-65.
1999: KM Kopydlowski; Cindy A Salkowski; M Joshua Cody; Nico van Rooijen; Jennifer Major; Thomas Hamilton; Stefanie N Vogel
Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1537-44.
1999: Laura K Hanson; Jacquelyn S Slater; Zaruhi Karabekian; HW Virgin; Christine A Biron; MC Ruzek; Nico van Rooijen; Richard P Ciavarra; Richard M Stenberg; Ann E Campbell
Replication of murine cytomegalovirus in differentiated macrophages as a determinant of viral pathogenesis.
Journal of virology 1999;73(7):5970-80.
1999: Q Jiang; Louis J DeTolla; Ishwar S Singh; L Gatdula; B Fitzgerald; Nico van Rooijen; Alan S Cross; Jeffrey D Hasday
Exposure to febrile temperature upregulates expression of pyrogenic cytokines in endotoxin-challenged mice.
The American journal of physiology 1999;276(6 Pt 2):R1653-60.
1999: Marina S Palermo; MF Alves Rosa; Nico van Rooijen; Martín A Isturiz
Depletion of liver and splenic macrophages reduces the lethality of Shiga toxin-2 in a mouse model.
Clinical and experimental immunology 1999;116(3):462-7.
1999: Q Jiang; Louis J DeTolla; Nico van Rooijen; Ishwar S Singh; B Fitzgerald; Michael Lipsky; Andrew S Kane; Alan S Cross; Jeffrey D Hasday
Febrile-range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin.
Infection and immunity 1999;67(4):1539-46.
1998: Gerard van der Veen; Lidy Broersma; Nico van Rooijen; Gabriel van Rij; Ruth van der Gaag
Cytotoxic T lymphocytes and antibodies after orthotropic penetrating keratoplasty in rats treated with dichloromethylene diphosphonate encapsulated liposomes.
Current eye research 1998;17(10):1018-26.
1998: J Bakker; A Sanders; Nico van Rooijen
Effects of liposome-encapsulated drugs on macrophages: comparative activity of the diamidine 4',6-diamidino-2-phenylindole and the phenanthridinium salts ethidium bromide and propidium iodide.
Biochimica et biophysica acta 1998;1373(1):93-100.
1998: Stephen H Gregory; Edward J Wing; K L Danowski; Nico van Rooijen; Kevin F Dyer; David Tweardy
IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):6056-61.
1998: Christien Oussoren; Maria J Velinova; Gerrit L Scherphof; Johannes van der Want; Nico van Rooijen; Gert Storm
Lymphatic uptake and biodistribution of liposomes after subcutaneous injection . IV. Fate of liposomes in regional lymph nodes.
Biochimica et biophysica acta 1998;1370(2):259-72.
1998: Odilia L C Wijburg; G P van den Dobbelsteen; Jim Vadolas; A Sanders; Richard A Strugnell; Nico van Rooijen
The role of macrophages in the induction and regulation of immunity elicited by exogenous antigens.
European journal of immunology 1998;28(2):479-87.
1997: Nico van Rooijen; A Sanders
Elimination, blocking, and activation of macrophages: three of a kind?
Journal of leukocyte biology 1997;62(6):702-9.
1997: Odilia L C Wijburg; S DiNatale; Jim Vadolas; Nico van Rooijen; Richard A Strugnell
Alveolar macrophages regulate the induction of primary cytotoxic T-lymphocyte responses during influenza virus infection.
Journal of virology 1997;71(12):9450-7.
1997: Odilia L C Wijburg; M H Heemskerk; C J Boog; Nico van Rooijen
Role of spleen macrophages in innate and acquired immune responses against mouse hepatitis virus strain A59.
Immunology 1997;92(2):252-8.
1997: Nico van Rooijen; J Bakker; A Sanders
Transient suppression of macrophage functions by liposome-encapsulated drugs.
Trends in biotechnology 1997;15(5):178-85.
1997: C P Rossi; M Delcroix; I Huitinga; A McAllister; Nico van Rooijen; E Claassen; Michel Brahic
Role of macrophages during Theiler's virus infection.
Journal of virology 1997;71(4):3336-40.
1997: M E Reinders; Bart A van Wagensveld; Thomas M van Gulik; N P Corssmit; Wilma M Frederiks; Robert Chamuleau; Nico van Rooijen; Huug Obertop
No attenuation of ischemic and reperfusion injury in Kupffer cell-depleted, cold-preserved rat livers.
Transplantation 1997;63(3):449-54.
1997: Richard P Ciavarra; K Buhrer; Nico van Rooijen; B Tedeschi
T cell priming against vesicular stomatitis virus analyzed in situ: red pulp macrophages, but neither marginal metallophilic nor marginal zone macrophages, are required for priming CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1749-55.
1997: Cindy A Salkowski; GR Detore; R McNally; Nico van Rooijen; Stefanie N Vogel
Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo: the roles of macrophages, endogenous IFN-gamma, and TNF receptor-1-mediated signaling.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):905-12.
1997: Gerhard Wolff; Stefan Worgall; Nico van Rooijen; WR Song; Ben-Gary Harvey; Helen-Ann Brown Epstein
Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ.
Journal of virology 1997;71(1):624-9.
1996: Nico van Rooijen; A Sanders; Timo K van den Berg
Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine.
Journal of immunological methods 1996;193(1):93-9.
1996: A M Buiting; F Zhou; J A Bakker; Nico van Rooijen; L Huang
Biodistribution of clodronate and liposomes used in the liposome mediated macrophage 'suicide' approach.
Journal of immunological methods 1996;192(1-2):55-62.
1996: Nico van Rooijen; A Sanders
Kupffer cell depletion by liposome-delivered drugs: comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid.
Hepatology (Baltimore, Md.) 1996;23(5):1239-43.
1996: A M Buiting; Z De Rover; Georg Kraal; Nico van Rooijen
Humoral immune responses against particulate bacterial antigens are dependent on marginal metallophilic macrophages in the spleen.
Scandinavian journal of immunology 1996;43(4):398-405.
1996: A Boelen; M C Platvoet-ter Schiphorst; Nico van Rooijen; Wilmar M Wiersinga
Selective macrophage depletion in the liver does not prevent the development of the sick euthyroid syndrome in the mouse.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(4):513-8.
1996: Odilia L C Wijburg; M H Heemskerk; A Sanders; Claire J P Boog; Nico van Rooijen
Role of virus-specific CD4+ cytotoxic T cells in recovery from mouse hepatitis virus infection.
Immunology 1996;87(1):34-41.
1996: Nico van Rooijen; Odilia L C Wijburg; G P van den Dobbelsteen; A Sanders
Macrophages in host defense mechanisms.
Current topics in microbiology and immunology 1996;210():159-65.
1995: Cindy A Salkowski; R Neta; T A Wynn; G Strassmann; Nico van Rooijen; Stefanie N Vogel
Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(6):3168-79.
1995: C C Fraser; B P Chen; S Webb; Nico van Rooijen; Georg Kraal
Circulation of human hematopoietic cells in severe combined immunodeficient mice after Cl2MDP-liposome-mediated macrophage depletion.
Blood 1995;86(1):183-92.
1995: I Huitinga; S R Ruuls; S Jung; Nico van Rooijen; H P Hartung; Christine D Dijkstra
Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats.
Clinical and experimental immunology 1995;100(2):344-51.
1995: J Biewenga; M B van der Ende; L F Krist; A Borst; M Ghufron; Nico van Rooijen
Macrophage depletion in the rat after intraperitoneal administration of liposome-encapsulated clodronate: depletion kinetics and accelerated repopulation of peritoneal and omental macrophages by administration of Freund's adjuvant.
Cell and tissue research 1995;280(1):189-96.
1995: K Schotanus; G M Holtkamp; Nico van Rooijen; Fred J H Tilders; F Berkenbosch
Circulating tumor necrosis factor-alpha does not mediate endotoxin-induced hypothermia in rats.
The American journal of physiology 1995;268(4 Pt 2):R989-96.
1995: A M Buiting; Z De Rover; Nico van Rooijen
Brucella abortus causes an accelerated repopulation of the spleen and liver of mice by macrophages after their liposome-mediated depletion.
Journal of medical microbiology 1995;42(2):133-40.
1995: Nico van Rooijen; J Bakker; A Sanders; J Mellink
Killing of Entamoeba invadens using liposome-encapsulated drugs.
Parasitology research 1995;81(3):258-61.
1994: Nico van Rooijen; A Sanders
Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications.
Journal of immunological methods 1994;174(1-2):83-93.
1994: J F Wijffels; Z de Rover; Robert H J Beelen; Georg Kraal; Nico van Rooijen
Macrophage subpopulations in the mouse spleen renewed by local proliferation.
Immunobiology 1994;191(1):52-64.
1994: R H Derijk; M Van Kampen; Nico van Rooijen; F Berkenbosch
Hypothermia to endotoxin involves reduced thermogenesis, macrophage-dependent mechanisms, and prostaglandins.
The American journal of physiology 1994;266(1 Pt 2):R1-8.
1994: Nico van Rooijen
Liposome mediated modulation of macrophage functions.
Advances in experimental medicine and biology 1994;355():69-74.
1994: A M Buiting; Nico van Rooijen
Liposome mediated depletion of macrophages: an approach for fundamental studies.
Journal of drug targeting 1994;2(5):357-62.
1993: R H Derijk; P J Strijbos; Nico van Rooijen; Nancy J Rothwell; F Berkenbosch
Fever and thermogenesis in response to bacterial endotoxin involve macrophage-dependent mechanisms in rats.
The American journal of physiology 1993;265(5 Pt 2):R1179-83.
1993: Nico van Rooijen
The role of the FDC-retained immune complex network and its dynamics in the activity of germinal centres.
Research in immunology 1993;144(8):545-52.
1993: G P van den Dobbelsteen; K Brunekreef; H Kroes; Nico van Rooijen; EP van Rees
Enhanced triggering of mucosal immune responses by reducing splenic phagocytic functions.
European journal of immunology 1993;23(7):1488-93.
1993: A M Buiting; Z de Rover; E Claassen; Nico van Rooijen
In vivo distribution of particulate antigens and liposomes in murine spleen. A possible role in the humoral immune response.
Immunobiology 1993;188(1-2):13-22.
1993: Nico van Rooijen
Extracellular and intracellular action of clodronate in osteolytic bone diseases? A hypothesis.
Calcified tissue international 1993;52(6):407-10.
1993: J Dulak; J Bauer; Ed A Döpp; Nico van Rooijen
Immune-complex-trapping cells in the spleen of the oriental fire-bellied toad, Bombina orientalis.
Cell and tissue research 1993;271(1):155-8.
1992: Nico van Rooijen; A Poppema
Efficacy of various water-soluble chelator molecules in the liposome-mediated macrophage "suicide" technique.
Journal of pharmacological and toxicological methods 1992;28(4):217-21.
1992: Nico van Rooijen
Macrophages as accessory cells in the in vivo humoral immune response: from processing of particulate antigens to regulation by suppression.
Seminars in immunology 1992;4(4):237-45.
1992: Nico van Rooijen; H ter Hart; Georg Kraal; N Kors; E Claassen
Monoclonal antibody mediated targeting of enzymes. A comparative study using the mouse spleen as a model system.
Journal of immunological methods 1992;151(1-2):149-55.
1992: A M Buiting; Nico van Rooijen; E Claassen
Liposomes as antigen carriers and adjuvants in vivo.
Research in immunology 1992;143(5):541-8; discussion 578-9.
1992: I Huitinga; J G Damoiseaux; Nico van Rooijen; Ed A Döpp; Christine D Dijkstra
Liposome mediated affection of monocytes.
Immunobiology 1992;185(1):11-9.
1992: R H Derijk; Nico van Rooijen; F Berkenbosch
The role of macrophages in the hypothalamic-pituitary-adrenal activation in response to endotoxin (LPS).
Research in immunology 1992;143(2):224-9.
1991: G P van den Dobbelsteen; Nico van Rooijen; T Sminia; EP van Rees
The immune response in the rat to Streptococcus pneumoniae type 3 and type 4 capsular polysaccharide. Detection by double immunocytochemical staining of antibody-containing cells in situ and ELISA.
Journal of immunological methods 1991;145(1-2):93-103.
1991: J F Wijffels; Z de Rover; Nico van Rooijen; Georg Kraal; Robert H J Beelen
Chronic inflammation induces the expression of dendritic cell markers not related to functional antigen presentation on peritoneal exudate macrophages.
Immunobiology 1991;184(1):83-92.
1991: F G Delemarre; N Kors; Nico van Rooijen
Development of antibody-forming cells in follicles of lymph nodes of mice after continuous antigenic stimulation.
Immunobiology 1991;184(1):75-82.
1991: M Soesatyo; J Biewenga; Nico van Rooijen; N Kors; T Sminia
The in situ immune response of the rat after intraperitoneal depletion of macrophages by liposome-encapsulated dichloromethylene diphosphonate.
Research in immunology 1991;142(7):533-40.
1991: R Derijk; Nico van Rooijen; Fred J H Tilders; Hugo O Besedovsky; Adriana del Rey; F Berkenbosch
Selective depletion of macrophages prevents pituitary-adrenal activation in response to subpyrogenic, but not to pyrogenic, doses of bacterial endotoxin in rats.
Endocrinology 1991;129(1):330-8.
1991: Nico van Rooijen
High and low cytosolic Ca2+ induced macrophage death? Hypothesis.
Cell calcium 1991;12(6):381-4.
1991: Nico van Rooijen
The humoral immune response in the spleen.
Research in immunology 1991;142(4):328-30.
1991: Nico van Rooijen
The role of antigens, antibodies and immune complexes in the functional activity of germinal centres.
Research in immunology 1991;142(3):272-5.
1990: F G Delemarre; N Kors; Nico van Rooijen
Elimination of spleen and of lymph node macrophages and its difference in the effect on the immune response to particulate antigens.
Immunobiology 1990;182(1):70-8.
1990: Nico van Rooijen
Antigen processing and presentation in vivo: the microenvironment as a crucial factor.
Immunology today 1990;11(12):436-9.
1990: I Huitinga; Nico van Rooijen; Christianne J M De Groot; Bernard Uitdehaag; Christine D Dijkstra
Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages.
The Journal of experimental medicine 1990;172(4):1025-33.
1990: Jon D Laman; N Kors; Nico van Rooijen; E Claassen
Mechanism of follicular trapping: localization of immune complexes and cell remnants after elimination and repopulation of different spleen cell populations.
Immunology 1990;71(1):57-62.
1990: F G Delemarre; N Kors; Nico van Rooijen
The in situ immune response in popliteal lymph nodes of mice after macrophage depletion. Differential effects of macrophages on thymus-dependent and thymus-independent immune responses.
Immunobiology 1990;180(4-5):395-404.
1990: Nico van Rooijen
Direct intrafollicular differentiation of memory B cells into plasma cells.
Immunology today 1990;11(5):154-7.
1990: Nico van Rooijen; N Kors; M vd Ende; Christine D Dijkstra
Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate.
Cell and tissue research 1990;260(2):215-22.
1990: F G Delemarre; N Kors; Georg Kraal; Nico van Rooijen
Repopulation of macrophages in popliteal lymph nodes of mice after liposome-mediated depletion.
Journal of leukocyte biology 1990;47(3):251-7.
1989: Nico van Rooijen
The liposome-mediated macrophage 'suicide' technique.
Journal of immunological methods 1989;124(1):1-6.
1989: Georg Kraal; H Rodrigues; K Hoeben; Nico van Rooijen
Lymphocyte migration in the spleen: the effect of macrophage elimination.
Immunology 1989;68(2):227-32.
1989: E Claassen; A Ott; Wim J A Boersma; C Deen; Marc M Schellekens; Christine D Dijkstra; N Kors; Nico van Rooijen
Marginal zone of the murine spleen in autotransplants: functional and histological observations in the response against a thymus-independent type 2 antigen.
Clinical and experimental immunology 1989;77(3):445-51.
1989: Nico van Rooijen; N Kors
Effects of intracellular diphosphonates on cells of the mononuclear phagocyte system: in vivo effects of liposome-encapsulated diphosphonates on different macrophage subpopulations in the spleen.
Calcified tissue international 1989;45(3):153-6.
1989: T Thepen; Nico van Rooijen; Georg Kraal
Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice.
The Journal of experimental medicine 1989;170(2):499-509.
1989: D Su; Nico van Rooijen
The role of macrophages in the immunoadjuvant action of liposomes: effects of elimination of splenic macrophages on the immune response against intravenously injected liposome-associated albumin antigen.
Immunology 1989;66(3):466-70.
1989: F G Delemarre; E Claassen; Nico van Rooijen
Primary in situ immune response in popliteal lymph nodes and spleen of mice after subcutaneous immunization with thymus-dependent or thymus-independent (type 1 and 2) antigens.
The Anatomical record 1989;223(2):152-7.
1989: Nico van Rooijen; N Kors; Georg Kraal
Macrophage subset repopulation in the spleen: differential kinetics after liposome-mediated elimination.
Journal of leukocyte biology 1989;45(2):97-104.
1988: E Claassen; Y Westerhof; B Versluis; N Kors; Marc M Schellekens; Nico van Rooijen
Effects of chronic injection of sphingomyelin-containing liposomes on lymphoid and non-lymphoid cells in the spleen. Transient suppression of marginal zone macrophages.
British journal of experimental pathology 1988;69(6):865-75.
1988: P H Groeneveld; E Claassen; frieke kuper; Nico van Rooijen
The role of macrophages in LPS-induced lethality and tissue injury.
Immunology 1988;63(3):521-7.
1988: Nico van Rooijen; N Kors
Specific antibody forming cells in lymphoid follicles of spleen: an aspect of the late immune response.
Advances in experimental medicine and biology 1988;237():221-5.
1988: Nico van Rooijen; N Kors; Georg Kraal
Characterization of cell populations, reappearing in the mouse spleen after elimination by liposome encapsulated dichloromethylene diphosphonate: reappearance of marginal zone lymphocytes is independent of marginal zone macrophages.
Advances in experimental medicine and biology 1988;237():889-93.
1988: Nico van Rooijen; N Kors; H ter Hart; E Claassen
In vitro and in vivo elimination of macrophage tumor cells using liposome-encapsulated dichloromethylene diphosphonate.
Virchows Archiv. B, Cell pathology including molecular pathology 1988;54(4):241-5.
1987: EP van Rees; Christine D Dijkstra; Nico van Rooijen
The early postnatal development of the primary immune response in rat popliteal lymph node, stimulated with thymus-independent type-1 and type-2 antigens.
Cell and tissue research 1987;250(3):695-9.
1987: Nico van Rooijen
The "in situ" immune response in lymph nodes: a review.
The Anatomical record 1987;218(4):359-64.
1987: Nico van Rooijen
The limitations of immunoenzyme approaches to distinguish between 'specific' and 'non-specific' antibody-forming cells, with particular respect to immunocytochemical studies on the in situ immune response.
The Histochemical journal 1987;19(6-7):369-74.
1987: G J van der Brugge-Gamelkoorn; N Kors; Nico van Rooijen
Development of specific antibody-forming cells in various lymphoid organs of rabbit after intravenous antigen administration.
The Anatomical record 1987;217(1):56-60.