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Frans van Roy

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TOP 3
Frans van Roy
Molecular biology of cadherins. Preface.
Irene Kahr; Karl Vandepoele; Frans van Roy
Delta-protocadherins in health and disease.
Paco Hulpiau; Ismail Sahin Gul; Frans van Roy
New insights into the evolution of metazoan cadherins and catenins.

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2013: Frans van Roy
Molecular biology of cadherins. Preface.
Progress in molecular biology and translational science 2013;116():xv-xviii.
2013: Irene Kahr; Karl Vandepoele; Frans van Roy
Delta-protocadherins in health and disease.
Progress in molecular biology and translational science 2013;116():169-92.
2013: Paco Hulpiau; Ismail Sahin Gul; Frans van Roy
New insights into the evolution of metazoan cadherins and catenins.
Progress in molecular biology and translational science 2013;116():71-94.
2013: Jolanda van Hengel; Frans van Roy; Mara Vleeschouwers; Tania Zaglia; Ilaria Rigato; Gaetano Thiene; Koen Tyberghein; Evelien van Hamme; Cristina Basso; Barbara Bauce; Giorgia Beffagna; Martina Calore; Domenico Corrado; Luciano Daliento; Emanuela Dazzo; Marzia De Bortoli; Paco Hulpiau; Ilena E A Li Mura; Alessandra Lorenzon; Elisa Mazzotti; Andrea Nava; Alessandra Rampazzo
Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy.
European heart journal 2013;34(3):201-10.
2012: Tim Pieters; Frans van Roy; Jinke D'Hont; Lieven Haenebalcke; Jody J Haigh; Tino Hochepied; Jolanda van Hengel
Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells.
Stem cell reviews 2012;8(3):768-78.
2012: Huiyu Tian; Albert Reynolds; Ellen Sanders; Frans van Roy; Jolanda van Hengel
Ocular anterior segment dysgenesis upon ablation of p120 catenin in neural crest cells.
Investigative ophthalmology & visual science 2012;53(9):5139-53.
2012: Bart Hooghe; Frans van Roy; Stefan Broos; Pieter De Bleser
A flexible integrative approach based on random forest improves prediction of transcription factor binding sites.
Nucleic acids research 2012;40(14):e106.
2012: Alexander Gheldof; Paco Hulpiau; Frans van Roy; Bram De Craene; Geert Berx
Evolutionary functional analysis and molecular regulation of the ZEB transcription factors.
Cellular and molecular life sciences : CMLS 2012;69(15):2527-41.
2012: K Tyberghein; Steven Goossens; Jody J Haigh; Frans van Roy; Jolanda van Hengel
Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice.
Placenta 2012;33(7):554-60.
2012: Jifen Li; Lan Cheng; Riet De Rycke; Erhe Gao; Steven Goossens; Xiying Shang; Koen Tyberghein; Jolanda van Hengel; Frans van Roy; Glenn L Radice
Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia.
Journal of cell science 2012;125(Pt 4):1058-67.
2011: Hong Thi Tran; L Van Hoorebeke; Frans van Roy; Veerle Verschuere; Dominique Adriaens; Ellen Crabbe; Mieke Delvaeye; Emilie Descamps; Pierre D McCrea; Kris Vleminckx
ARVCF depletion cooperates with Tbx1 deficiency in the development of 22q11.2DS-like phenotypes in Xenopus.
Developmental dynamics : an official publication of the American Association of Anatomists 2011;240(12):2680-7.
2011: Stefan Broos; Jeroen Galle; Bart Hooghe; Paco Hulpiau; Frans van Roy; Pieter De Bleser
ConTra v2: a tool to identify transcription factor binding sites across species, update 2011.
Nucleic acids research 2011;39(Web Server issue):W74-8.
2011: Paco Hulpiau; Frans van Roy
New insights into the evolution of metazoan cadherins.
Molecular biology and evolution 2011;28(1):647-57.
2010: Nicolas Willemarck; Evelien Rysman; Koen Brusselmans; Griet Van Imschoot; Frank Vanderhoydonc; Katrien B Moerloose; Evelyne Lerut; Guido Verhoeven; Frans van Roy; Kris Vleminckx; Johannes V Swinnen
Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development.
Cancer research 2010;70(22):9453-62.
2010: Julien Lambert; S Bracke; Frans van Roy; H H Pas; Stefan Bonné; Sofie de Schepper
Serum plakophilin-3 autoreactivity in paraneoplastic pemphigus.
The British journal of dermatology 2010;163(3):630-2.
2010: Karl Vandepoele; Katrien Staes; Vanessa Andries; Frans van Roy
Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma.
Experimental cell research 2010;316(7):1225-33.
2010: Sylvie Janssens; Tinneke Denayer; Tom Deroo; Frans van Roy; Kris Vleminckx
Direct control of Hoxd1 and Irx3 expression by Wnt/beta-catenin signaling during anteroposterior patterning of the neural axis in Xenopus.
The International journal of developmental biology 2010;54(10):1435-42.
2010: Adelheid Soubry; Katrien Staes; Eef Parthoens; Sam Noppen; Christophe Stove; Pieter Bogaert; Jolanda van Hengel; Frans van Roy
The transcriptional repressor Kaiso localizes at the mitotic spindle and is a constituent of the pericentriolar material.
PloS one 2010;5(2):e9203.
2009: Karl Vandepoele; Vanessa Andries; Frans van Roy
The NBPF1 promoter has been recruited from the unrelated EVI5 gene before simian radiation.
Molecular biology and evolution 2009;26(6):1321-32.
2009: Eric Chastre; mahmoud Abdessamad; Alexey Kruglov; Erik Bruyneel; Marc Bracke; Yolande Di Gioia; Mary C Beckerle; Frans van Roy; Larissa Kotelevets
TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(3):916-28.
2009: Cindy Vandewalle; Frans van Roy; Geert Berx
The role of the ZEB family of transcription factors in development and disease.
Cellular and molecular life sciences : CMLS 2009;66(5):773-87.
2009: Paco Hulpiau; Frans van Roy
Molecular evolution of the cadherin superfamily.
The international journal of biochemistry & cell biology 2009;41(2):349-69.
2008: Frans van Roy; Geert Berx
The cell-cell adhesion molecule E-cadherin.
Cellular and molecular life sciences : CMLS 2008;65(23):3756-88.
2008: Christoph Redies; Jessica Heyder; Tomás Kohoutek; Katrien Staes; Frans van Roy
Expression of protocadherin-1 (Pcdh1) during mouse development.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(9):2496-505.
2008: Tinneke Denayer; Morgane Locker; Caroline Borday; Tom Deroo; Sylvie Janssens; Andreas Hecht; Frans van Roy; Muriel Perron; Kris Vleminckx
Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes.
Stem cells (Dayton, Ohio) 2008;26(8):2063-74.
2008: Belaïd Sekkali; Hong Thi Tran; Ellen Crabbe; Christophe De Beule; Frans van Roy; Kris Vleminckx
Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2534-40.
2008: A Bonnomet; Myriam Polette; K Strumane; Christine Gilles; V Dalstein; C Kileztky; G Berx; Frans van Roy; Philippe Birembaut; Béatrice Nawrocki-Raby
The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression.
Oncogene 2008;27(26):3692-9.
2008: Tatyana Sklyarova; Stefan Bonné; Petra D'Hooge; Geertrui Denecker; Steven Goossens; Riet De Rycke; Gaetan Borgonie; Michael Bösl; Frans van Roy; Jolanda van Hengel
Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation.
The Journal of investigative dermatology 2008;128(6):1375-85.
2008: C Wiesner; Gabriele Winsauer; Ulrike Resch; Martina Hoeth; Johannes A Schmid; J van Hengel; Frans van Roy; Bernd R Binder; Rainer de Martin
Alpha-catulin, a Rho signalling component, can regulate NF-kappaB through binding to IKK-beta, and confers resistance to apoptosis.
Oncogene 2008;27(15):2159-69.
2008: Karl Vandepoele; Vanessa Andries; Nadine Van Roy; Katrien Staes; Jo Vandesompele; Geneviève Laureys; Els De Smet; Geert Berx; Frank Speleman; Frans van Roy
A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genes.
PloS one 2008;3(5):e2207.
2007: Steven Goossens; Barbara Janssens; Stefan Bonné; Riet De Rycke; Filip Braet; Jolanda van Hengel; Frans van Roy
A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs.
Journal of cell science 2007;120(Pt 12):2126-36.
2007: Karl Vandepoele; Frans van Roy
Insertion of an HERV(K) LTR in the intron of NBPF3 is not required for its transcriptional activity.
Virology 2007;362(1):1-5.
2007: Kurt Aigner; Luise Descovich; Mario Mikula; Aneesa Sultan; Brigitta Dampier; Stefan Bonné; Frans van Roy; Wolfgang Mikulits; Martin Schreiber; Thomas Brabletz; Wolfgang Sommergruber; Norbert Schweifer; Andreas Wernitznig; Hartmut Beug; Roland Foisner; Andreas Eger
The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression.
FEBS letters 2007;581(8):1617-24.
2007: Ben Wielockx; Jeroen Staelens; Leen Puimège; Ineke Vanlaere; Maarten Van Roy; Philippe Van Lint; Frans van Roy; Claude Libert
Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):5069-75.
2007: Steven Goossens; Barbara Janssens; Griet Vanpoucke; Riet De Rycke; Jolanda van Hengel; Frans van Roy
Truncated isoform of mouse alphaT-catenin is testis-restricted in expression and function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(3):647-55.
2007: Jolanda van Hengel; Frans van Roy
Diverse functions of p120ctn in tumors.
Biochimica et biophysica acta 2007;1773(1):78-88.
2006: Kristin Strumane; Arnaud Bonnomet; Christophe Stove; Roosmarijn Vandenbroucke; Béatrice Nawrocki-Raby; Erik Bruyneel; Marc Mareel; Philippe Birembaut; Geert Berx; Frans van Roy
E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion.
Cancer research 2006;66(20):10007-15.
2006: Amin S Bredan; Frans van Roy
Writing readable prose: when planning a scientific manuscript, following a few simple rules has a large impact.
EMBO reports 2006;7(9):846-9.
2006: S Bindels; Mélanie Mestdagt; Cindy Vandewalle; Nathalie Jacobs; L Volders; Agnès Noël; Frans van Roy; Geert Berx; Jean-Michel Foidart; Christine Gilles
Regulation of vimentin by SIP1 in human epithelial breast tumor cells.
Oncogene 2006;25(36):4975-85.
2006: Tina Mahieu; Jin Mo Park; Hilde Revets; Bastian Pasche; Andreas Lengeling; Jeroen Staelens; Andy Wullaert; Ineke Vanlaere; Tino Hochepied; Frans van Roy; Michael Karin; Claude Libert
The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2292-7.
2006: Tinneke Denayer; Frans van Roy; Kris Vleminckx
In vivo tracing of canonical Wnt signaling in Xenopus tadpoles by means of an inducible transgenic reporter tool.
FEBS letters 2006;580(2):393-8.
2006: Dominique Vlieghe; Albin Sandelin; Pieter J De Bleser; Kris Vleminckx; Wyeth W Wasserman; Frans van Roy; Boris Lenhard
A new generation of JASPAR, the open-access repository for transcription factor binding site profiles.
Nucleic acids research 2006;34(Database issue):D95-7.
2005: Frans van Roy; Pierre D McCrea
A role for Kaiso-p120ctn complexes in cancer?
Nature reviews. Cancer 2005;5(12):956-64.
2005: Sven Bogaerts; Ann Vanlandschoot; Jolanda van Hengel; Frans van Roy
Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1.
Experimental cell research 2005;311(1):1-13.
2005: Karl Vandepoele; Nadine Van Roy; Katrien Staes; Frank Speleman; Frans van Roy
A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.
Molecular biology and evolution 2005;22(11):2265-74.
2005: Bram De Craene; Barbara Gilbert; Christophe Stove; Erik Bruyneel; Frans van Roy; Geert Berx
The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program.
Cancer research 2005;65(14):6237-44.
2005: K Vanhalst; Patrick Kools; Katrien Staes; Frans van Roy; Christoph Redies
delta-Protocadherins: a gene family expressed differentially in the mouse brain.
Cellular and molecular life sciences : CMLS 2005;62(11):1247-59.
2005: Bram De Craene; Frans van Roy; Geert Berx
Unraveling signalling cascades for the Snail family of transcription factors.
Cellular signalling 2005;17(5):535-47.
2005: Adelheid Soubry; Jolanda van Hengel; Eef Parthoens; Cecile G Colpaert; Eric Van Marck; David Waltregny; Albert B Reynolds; Frans van Roy
Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment.
Cancer research 2005;65(6):2224-33.
2005: Cindy Vandewalle; Joke Comijn; Bram De Craene; Petra Vermassen; Erik Bruyneel; Henriette Andersen; Eugene Tulchinsky; Frans van Roy; Geert Berx
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions.
Nucleic acids research 2005;33(20):6566-78.
2005: Larissa Kotelevets; Jolanda van Hengel; Erik Bruyneel; Marc Mareel; Frans van Roy; Eric Chastre
Implication of the MAGI-1b/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):115-7.
2005: Steven Goossens; Frans van Roy
Cadherin-mediated cell-cell adhesion in the testis.
Frontiers in bioscience : a journal and virtual library 2005;10():398-419.
2004: Tom Deroo; Tinneke Denayer; Frans van Roy; Kris Vleminckx
Global inhibition of Lef1/Tcf-dependent Wnt signaling at its nuclear end point abrogates development in transgenic Xenopus embryos.
The Journal of biological chemistry 2004;279(49):50670-5.
2004: Marie Van Dijk; Joyce Mulders; Andrea A M Könst; Barbara Janssens; Frans van Roy; Marinus A Blankenstein; Cees B M Oudejans
Differential downregulation of alphaT-catenin expression in placenta: trophoblast cell type-dependent imprinting of the CTNNA3 gene.
Gene expression patterns : GEP 2004;5(1):61-5.
2004: Malgorzata Ciesiolka; Mieke Delvaeye; Griet Van Imschoot; Veerle Verschuere; Pierre D McCrea; Frans van Roy; Kris Vleminckx
p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus.
Journal of cell science 2004;117(Pt 18):4325-39.
2004: Jeroen Staelens; Leen Puimège; Tina Mahieu; Gwenda Pynaert; Tino Hochepied; Annelies Vandenabeele; Johan Grooten; Dimitris L Kontoyiannis; Frans van Roy; george kollias; Claude Libert
Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(7):537-43.
2004: Frédéric André; Barbara Janssens; Erik Bruyneel; Frans van Roy; Christian Gespach; Marc Mareel; Marc Bracke
Alpha-catenin is required for IGF-I-induced cellular migration but not invasion in human colonic cancer cells.
Oncogene 2004;23(6):1177-86.
2004: Katleen De Preter; Filip Pattyn; Geert Berx; Kristin Strumane; Björn Menten; Frans van Roy; Anne De Paepe; Frank Speleman; Jo Vandesompele
Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons.
BMC genomics 2004;5(1):11.
2004: Kristin Strumane; Geert Berx; Frans van Roy
Cadherins in cancer.
Handbook of experimental pharmacology 2004;(165):69-103.
2004: Griet Vanpoucke; Steven Goossens; Bram De Craene; Barbara Gilbert; Frans van Roy; Geert Berx
GATA-4 and MEF2C transcription factors control the tissue-specific expression of the alphaT-catenin gene CTNNA3.
Nucleic acids research 2004;32(14):4155-65.
2004: Tino Hochepied; Luc Schoonjans; Jeroen Staelens; Veerle Kreemers; Sophie Danloy; Leen Puimège; Désiré Collen; Frans van Roy; Claude Libert
Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids.
Stem cells (Dayton, Ohio) 2004;22(4):441-7.
2003: Philip Debruyne; Stefan Vermeulen; Geert Berx; Marc Pocard; Ana-Sofia Correia da Rocha; Xuedong Li; Luís Cirnes; Marie-France Poupon; Frans van Roy; Marc M Mareel
Functional and molecular characterization of the epithelioid to round transition in human colorectal cancer LoVo cells.
Oncogene 2003;22(46):7199-208.
2003: Béatrice Nawrocki-Raby; Christine Gilles; Myriam Polette; Corinne Martinella-Catusse; Noël Bonnet; Edith Puchelle; Jean-Michel Foidart; Frans van Roy; Philippe Birembaut
E-Cadherin mediates MMP down-regulation in highly invasive bronchial tumor cells.
The American journal of pathology 2003;163(2):653-61.
2003: Stefan Bonné; Barbara Gilbert; Mechthild Hatzfeld; Xinyu Chen; Kathleen J Green; Frans van Roy
Defining desmosomal plakophilin-3 interactions.
The Journal of cell biology 2003;161(2):403-16.
2003: Cecile G Colpaert; Peter B Vermeulen; Ina H Benoy; Adelheid Soubry; Frans van Roy; P van Beest; GC Goovaerts; Luc Y Dirix; Peter van Dam; Stephen B Fox; Adrian L Harris; Eric A Van Marck
Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression.
British journal of cancer 2003;88(5):718-25.
2003: Barbara Janssens; Bhagyalaxmi Mohapatra; Matteo Vatta; Steven Goossens; Griet Vanpoucke; Patrick Kools; Tony Montoye; Jolanda van Hengel; Neil E Bowles; Frans van Roy; Jeffrey A Towbin
Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy.
Human genetics 2003;112(3):227-36.
2002: Renee C Ireton; Michael A Davis; Jolanda van Hengel; Deborah J Mariner; Kirk Barnes; Molly A Thoreson; PZ Anastasiadis; Linsey Matrisian; Linda M Bundy; Linda Sealy; Barbara Gilbert; Frans van Roy; Albert B Reynolds
A novel role for p120 catenin in E-cadherin function.
The Journal of cell biology 2002;159(3):465-76.
2002: Nadine Van Roy; Jo Vandesompele; Geert Berx; Katrien Staes; Mireille Van Gele; Els De Smet; Anne De Paepe; Geneviève Laureys; Pauline van der Drift; Rogier Versteeg; Frans van Roy; Frank Speleman
Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients.
Genes, chromosomes & cancer 2002;35(2):113-20.
2002: Nicole Müller; Anke Reinacher-Schick; Stephan Baldus; Jolanda van Hengel; Geert Berx; Anke Baar; Frans van Roy; Wolff Schmiegel; Irmgard Schwarte-Waldhoff
Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.
Oncogene 2002;21(39):6049-58.
2002: Jeroen Staelens; Ben Wielockx; Leen Puimège; Frans van Roy; Jean-Louis Guénet; Claude Libert
Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9340-5.
2002: Griet Vanpoucke; Friedel Nollet; Sabine Tejpar; Jean-Jacques Cassiman; Frans van Roy
The human alphaE-catenin gene CTNNA1: mutational analysis and rare occurrence of a truncated splice variant.
Biochimica et biophysica acta 2002;1574(3):262-8.
2002: Xinyu Chen; Stefan Bonne; Mechthild Hatzfeld; Frans van Roy; Kathleen J Green
Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.
The Journal of biological chemistry 2002;277(12):10512-22.
2002: Si Wan Kim; Xiang Fang; Hong Ji; Alicia Paulson; Juliet M Daniel; Malgorzata Ciesiolka; Frans van Roy; Pierre D McCrea
Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120(ctn) in Xenopus laevis.
The Journal of biological chemistry 2002;277(10):8202-8.
2001: Larissa Kotelevets; Jolanda van Hengel; Erik Bruyneel; Marc Mareel; Frans van Roy; Eric Chastre
The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness.
The Journal of cell biology 2001;155(7):1129-35.
2001: Barbara Janssens; Steven Goossens; Katrien Staes; Barbara Gilbert; Jolanda van Hengel; Cecile G Colpaert; Erik Bruyneel; Marc Mareel; Frans van Roy
alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.
Journal of cell science 2001;114(Pt 17):3177-88.
2001: Béatrice Nawrocki-Raby; Myriam Polette; Christine Gilles; Christine Clavel; Kristin Strumane; Manuela Matos; Jean-Marie Zahm; Frans van Roy; Noël Bonnet; Philippe Birembaut
Quantitative cell dispersion analysis: new test to measure tumor cell aggressiveness.
International journal of cancer. Journal international du cancer 2001;93(5):644-52.
2001: J Comijn; Geert Berx; Petra Vermassen; Kristin Verschueren; Leo van Grunsven; Erik Bruyneel; Marc Mareel; Danny Huylebroeck; Frans van Roy
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.
Molecular cell 2001;7(6):1267-78.
2001: Christine Clavel; Friedel Nollet; Geert Berx; Sabine Tejpar; Béatrice Nawrocki-Raby; H H Kaplan; Frans van Roy; Philippe Birembaut
Expression of the E-cadherin-catenin complex in lung neuroendocrine tumours.
The Journal of pathology 2001;194(1):20-6.
2001: K Vanhalst; Patrick Kools; E Vanden Eynde; Frans van Roy
The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.
FEBS letters 2001;495(1-2):120-5.
2000: Patrick Kools; G Van Imschoot; Frans van Roy
Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7.
Genomics 2000;68(3):283-95.
2000: H Keilhack; U Hellman; Jolanda van Hengel; Frans van Roy; Jasminka Godovac-Zimmermann; Frank-D Böhmer
The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin.
The Journal of biological chemistry 2000;275(34):26376-84.
2000: Friedel Nollet; Patrick Kools; Frans van Roy
Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.
Journal of molecular biology 2000;299(3):551-72.
2000: Stefan Bonné; Jolanda van Hengel; Frans van Roy
Assignment of the plakophilin-2 gene (PKP2) and a plakophilin-2 pseudogene (PKP2P1) to human chromosome bands 12p11 and 12p13, respectively, by in situ hybridization.
Cytogenetics and cell genetics 2000;88(3-4):286-7.
1999: Sabine Tejpar; Friedel Nollet; C Li; J S Wunder; Geneviève Michils; P dal Cin; Eric Van Cutsem; Bharati Bapat; Frans van Roy; Jean-Jacques Cassiman; Benjamin A Alman
Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor).
Oncogene 1999;18(47):6615-20.
1999: Barbara Janssens; Katrien Staes; Frans van Roy
Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing.
Biochimica et biophysica acta 1999;1447(2-3):341-7.
1999: Friedel Nollet; Geert Berx; Frans van Roy
The role of the E-cadherin/catenin adhesion complex in the development and progression of cancer.
Molecular cell biology research communications : MCBRC 1999;2(2):77-85.
1999: Jolanda van Hengel; P Vanhoenacker; Katrien Staes; Frans van Roy
Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7980-5.
1999: Stefan Bonné; Jolanda van Hengel; Friedel Nollet; Patrick Kools; Frans van Roy
Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells.
Journal of cell science 1999;112 ( Pt 14)():2265-76.
1999: Patrick Kools; K Vanhalst; E Van den Eynde; Frans van Roy
The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14.
FEBS letters 1999;452(3):328-34.
1999: Stefan Vermeulen; Friedel Nollet; E Teugels; KM Vennekens; Fransiska Malfait; Jan Philippé; Frank Speleman; Marc Bracke; Frans van Roy; Marc M Mareel
The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells.
Oncogene 1999;18(4):905-15.
1999: Stefan Vermeulen; Philip Debruyne; G Marra; Frank Speleman; P Boukamp; J Jiricny; A P Cuthbert; Robert F Newbold; Friedel Nollet; Frans van Roy; Marc M Mareel
hMSH6 deficiency and inactivation of the alphaE-catenin invasion-suppressor gene in HCT-8 colon cancer cells.
Clinical & experimental metastasis 1999;17(8):663-8.
1999: Patrick Kools; K Vanhalst; Frans van Roy
Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3.
Cytogenetics and cell genetics 1999;86(1):26-7.
1998: B Nawrocki; Myriam Polette; Jolanda van Hengel; Jean-Marie Tournier; Frans van Roy; P Birembault
Cytoplasmic redistribution of E-cadherin-catenin adhesion complex is associated with down-regulated tyrosine phosphorylation of E-cadherin in human bronchopulmonary carcinomas.
The American journal of pathology 1998;153(5):1521-30.
1998: Stefan Vermeulen; T R Chen; Frank Speleman; Friedel Nollet; Frans van Roy; Marc M Mareel
Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?
Cancer genetics and cytogenetics 1998;107(1):76-9.
1998: A Keirsebilck; Stefan Bonné; Erik Bruyneel; Petra Vermassen; E Lukanidin; Marc Mareel; Frans van Roy
E-cadherin and metastasin (mts-1/S100A4) expression levels are inversely regulated in two tumor cell families.
Cancer research 1998;58(20):4587-91.
1998: Stefan Bonné; Jolanda van Hengel; Frans van Roy
Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily.
Genomics 1998;51(3):452-4.
1998: A Keirsebilck; Stefan Bonné; Katrien Staes; Jolanda van Hengel; Friedel Nollet; A Reynolds; Frans van Roy
Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms.
Genomics 1998;50(2):129-46.
1998: A Keirsebilck; Leen Van Hoorde; Y Gao; Georges de Bruyne; Erik Bruyneel; Petra Vermassen; Marc Mareel; Frans van Roy
Mechanisms of downregulation of transfected E-cadherin cDNA during formation of invasive tumors in syngeneic mice.
Invasion & metastasis 1998;18(1):44-56.
1998: Geert Berx; Friedel Nollet; Frans van Roy
Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.
Cell adhesion and communication 1998;6(2-3):171-84.
1998: Geert Berx; Karl-Friedrich Becker; H Höfler; Frans van Roy
Mutations of the human E-cadherin (CDH1) gene.
Human mutation 1998;12(4):226-37.
1997: Stefan Vermeulen; Friedel Nollet; E Teugels; J Philippe; Frank Speleman; Frans van Roy; Marc Bracke; Marc M Mareel
Mutation of alpha-catenin results in invasiveness of human HCT-8 colon cancer cells.
Annals of the New York Academy of Sciences 1997;833():186-9.
1997: Geert Berx; Friedel Nollet; Kristin Strumane; Frans van Roy
An efficient and reliable multiplex PCR-SSCP mutation analysis test applied to the human E-cadherin gene.
Human mutation 1997;9(6):567-74.
1997: S Empereur; S Djelloul; Yolande Di Gioia; Erik Bruyneel; Marc Mareel; Jolanda van Hengel; Frans van Roy; P Comoglio; S Courtneidge; C Paraskeva; Eric Chastre; Christian Gespach
Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion.
British journal of cancer 1997;75(2):241-50.
1996: Geert Berx; Anne-Marie Cleton-Jansen; K Strumane; Wiljo J F De Leeuw; Friedel Nollet; Frans van Roy; Cees J Cornelisse
E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.
Oncogene 1996;13(9):1919-25.
1996: Stefan Vermeulen; V Van Marck; Leen Van Hoorde; Frans van Roy; Marc Bracke; Marc Mareel
Regulation of the invasion suppressor function of the cadherin/catenin complex.
Pathology, research and practice 1996;192(7):694-707.
1996: Marc Mareel; Geert Berx; Frans van Roy; Marc Bracke
Cadherin/catenin complex: a target for antiinvasive therapy?
Journal of cellular biochemistry 1996;61(4):524-30.
1996: Sirpa Leppä; K Vleminckx; Frans van Roy; Markku Jalkanen
Syndecan-1 expression in mammary epithelial tumor cells is E-cadherin-dependent.
Journal of cell science 1996;109 ( Pt 6)():1393-403.
1996: C Van den Broecke; K Vleminckx; Georges de Bruyne; Leen Van Hoorde; L Vakaet; Frans van Roy; Marc Mareel
Morphotypic plasticity in vitro and in nude mice of epithelial mouse mammary cells (NMuMG) displaying an epithelioid (e) or a fibroblastic (f) morphotype in culture.
Clinical & experimental metastasis 1996;14(3):282-96.
1996: Friedel Nollet; Geert Berx; F Molemans; Frans van Roy
Genomic organization of the human beta-catenin gene (CTNNB1).
Genomics 1996;32(3):413-24.
1995: Geert Berx; Anne-Marie Cleton-Jansen; Friedel Nollet; Wiljo J F De Leeuw; Marc J van de Vijver; Cees J Cornelisse; Frans van Roy
E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.
The EMBO journal 1995;14(24):6107-15.
1995: Stefan Vermeulen; Erik Bruyneel; Frans van Roy; Marc M Mareel; Marc Bracke
Activation of the E-cadherin/catenin complex in human MCF-7 breast cancer cells by all-trans-retinoic acid.
British journal of cancer 1995;72(6):1447-53.
1995: Stefan Vermeulen; Erik Bruyneel; Marc Bracke; Georges de Bruyne; KM Vennekens; K L Vleminckx; G J Berx; Frans van Roy; Marc M Mareel
Transition from the noninvasive to the invasive phenotype and loss of alpha-catenin in human colon cancer cells.
Cancer research 1995;55(20):4722-8.
1995: Friedel Nollet; Jolanda van Hengel; Geert Berx; F Molemans; Frans van Roy
Isolation and characterization of a human pseudogene (CTNNAP1) for alpha E-catenin (CTNNA1): assignment of the pseudogene to 5q22 and the alpha E-catenin gene to 5q31.
Genomics 1995;26(2):410-3.
1995: Geert Berx; Katrien Staes; Jolanda van Hengel; F Molemans; M J G Bussemakers; A van Bokhoven; Frans van Roy
Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1).
Genomics 1995;26(2):281-9.
1995: Jolanda van Hengel; Friedel Nollet; Geert Berx; N van Roy; Frank Speleman; Frans van Roy
Assignment of the human beta-catenin gene (CTNNB1) to 3p22-->p21.3 by fluorescence in situ hybridization.
Cytogenetics and cell genetics 1995;70(1-2):68-70.
1994: G M Vandenbossche; Georges de Bruyne; Erik Bruyneel; G Clemminck; K Vleminckx; Frans van Roy; Marc M Mareel
Micro-encapsulation of MDCK-ras-e cells prevents loss of E-cadherin invasion-suppressor function in vivo.
International journal of cancer. Journal international du cancer 1994;57(1):73-80.
1994: K L Vleminckx; J J Deman; Erik Bruyneel; G M Vandenbossche; A A Keirsebilck; Marc M Mareel; Frans van Roy
Enlarged cell-associated proteoglycans abolish E-cadherin functionality in invasive tumor cells.
Cancer research 1994;54(4):873-7.
1994: Marc Mareel; K Vleminckx; Stefan Vermeulen; G Yan; Marc Bracke; Frans van Roy
Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer.
Princess Takamatsu symposia 1994;24():63-80.
1993: Eric Chastre; S Empereur; Y Di Gioia; N el Mahdani; Marc Mareel; K Vleminckx; Frans van Roy; V Bex; Shahin Emami; D A Spandidos
Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes.
Gastroenterology 1993;105(6):1776-89.
1993: Marc Bracke; B M Vyncke; Erik Bruyneel; Stefan Vermeulen; Georges de Bruyne; N A Van Larebeke; K Vleminckx; Frans van Roy; Marc M Mareel
Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro.
British journal of cancer 1993;68(2):282-9.
1993: Rudi Beyaert; Karen Heyninck; D De Valck; F Boeykens; Frans van Roy; Walter Fiers
Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):291-300.
1993: Rudi Beyaert; B Vanhaesebroeck; Karen Heyninck; Elke Boone; D De Valck; K Schulze-Osthoff; Guy Haegeman; Frans van Roy; Walter Fiers
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.
Cancer research 1993;53(11):2623-30.
1993: B Vanhaesebroeck; J C Reed; D De Valck; Johan Grooten; T Miyashita; S Tanaka; Rudi Beyaert; Frans van Roy; Walter Fiers
Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.
Oncogene 1993;8(4):1075-81.
1993: D De Valck; Rudi Beyaert; Frans van Roy; Walter Fiers
Tumor necrosis factor cytotoxicity is associated with phospholipase D activation.
European journal of biochemistry / FEBS 1993;212(2):491-7.
1992: Rudi Beyaert; K Schulze-Osthoff; Frans van Roy; Walter Fiers
Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice: possible role in the triggering and exacerbation of psoriasis by lithium treatment.
European journal of immunology 1992;22(8):2181-4.
1992: B Vanhaesebroeck; E Decoster; X Van Ostade; S Van Bladel; A Lenaerts; Frans van Roy; Walter Fiers
Expression of an exogenous tumor necrosis factor (TNF) gene in TNF-sensitive cell lines confers resistance to TNF-mediated cell lysis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(9):2785-94.
1992: Marc Mareel; K Vleminckx; Stefan Vermeulen; Y Gao; L Vakaet; Marc Bracke; Frans van Roy
Homotypic cell-cell adhesion molecules and tumor invasion.
Progress in histochemistry and cytochemistry 1992;26(1-4):95-106.
1992: Marc Mareel; K Vleminckx; Stefan Vermeulen; Marc Bracke; Frans van Roy
E-cadherin expression: a counterbalance for cancer cell invasion.
Bulletin du cancer 1992;79(4):347-55.
1991: P Coopman; Bruno Verhasselt; Marc Bracke; Georges de Bruyne; V Castronovo; M Sobel; J M Foidart; Frans van Roy; Marc Mareel
Arrest of MCF-7 cell migration by laminin in vitro: possible mechanisms.
Clinical & experimental metastasis 1991;9(5):469-84.
1991: K Vleminckx; L Vakaet; Marc Mareel; Walter Fiers; Frans van Roy
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.
Cell 1991;66(1):107-19.
1991: Rudi Beyaert; K Schulze-Osthoff; Frans van Roy; Walter Fiers
Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression.
Cytokine 1991;3(4):284-91.
1991: B Vanhaesebroeck; S Van Bladel; A Lenaerts; P Suffys; Rudi Beyaert; Rudolf Lucas; Frans van Roy; Walter Fiers
Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.
Cancer research 1991;51(9):2469-77.
1991: B Vanhaesebroeck; Marc Mareel; Frans van Roy; Johan Grooten; Walter Fiers
Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo.
Cancer research 1991;51(8):2229-38.
1991: Marc M Mareel; Jürgen Behrens; W Birchmeier; Georges de Bruyne; K Vleminckx; A Hoogewijs; Walter Fiers; Frans van Roy
Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice.
International journal of cancer. Journal international du cancer 1991;47(6):922-8.
1991: P J Coopman; Marc Bracke; J C Lissitzky; Georges de Bruyne; Frans van Roy; J M Foidart; Marc M Mareel
Influence of basement membrane molecules on directional migration of human breast cell lines in vitro.
Journal of cell science 1991;98 ( Pt 3)():395-401.
1991: Rudi Beyaert; Christian R De Potter; B Vanhaesebroeck; Frans van Roy; Walter Fiers
Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor necrosis factor and lithium chloride.
The American journal of pathology 1991;138(3):727-39.
1991: P Suffys; Rudi Beyaert; D De Valck; B Vanhaesebroeck; Frans van Roy; Walter Fiers
Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se.
European journal of biochemistry / FEBS 1991;195(2):465-75.
1991: L Vakaet; K Vleminckx; Frans van Roy; Marc Mareel
Numerical evaluation of the invasion of closely related cell lines into collagen type I gels.
Invasion & metastasis 1991;11(5):249-60.
1990: Frans van Roy; Marc Mareel; K Vleminckx; Rudi Beyaert; Walter Fiers; N Devleeschouwer; C Muquardt; N Legros; Marc Bracke; G Leclercq
Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives.
International journal of cancer. Journal international du cancer 1990;46(3):522-32.
1990: B Vanhaesebroeck; H T Timmers; G J Pronk; Frans van Roy; Alex J van der Eb; Walter Fiers
Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent.
Virology 1990;176(2):362-8.
1990: Rudi Beyaert; P Suffys; Frans van Roy; Walter Fiers
Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity. Evidence against lipocortin involvement.
FEBS letters 1990;262(1):93-6.
1990: B Vanhaesebroeck; E J Cragoe; J Pouysségur; Rudi Beyaert; Frans van Roy; Walter Fiers
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter.
FEBS letters 1990;261(2):319-22.
1990: Frans van Roy; G Liebaut; Marc Mareel; Walter Fiers
Partial transformation of human tumor cell lines showing defective interaction between unusual p53 gene product and SV40 large-T antigen.
Oncogene 1990;5(2):207-18.
1989: Rudi Beyaert; B Vanhaesebroeck; P Suffys; Frans van Roy; Walter Fiers
Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9494-8.
1989: Frans van Roy; P Coopman; P Suffys; G Liebaut; K Vleminckx; J Gao; C H Dragonetti; Walter Fiers; Marc M Mareel
Effect of oncogene transfection or passage in vivo on malignant phenotypes of rat2 cells.
Anticancer research 1989;9(6):1553-64.
1989: P Coopman; Frans van Roy; C Dragonetti; J Gao; W Fiers; G Meneguzzi; Marc Mareel
Tumorigenicity, invasiveness and metastatic capability of FR3T3 rat cells before and after transfection with bovine papilloma virus type 1 DNA.
Clinical & experimental metastasis 1989;7(1):69-84.
1989: P Suffys; Rudi Beyaert; Frans van Roy; Walter Fiers
TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells.
Anticancer research 1989;9(1):167-71.
1988: P Suffys; Rudi Beyaert; Frans van Roy; Walter Fiers
Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity.
European journal of biochemistry / FEBS 1988;178(1):257-65.
1988: P Suffys; Frans van Roy; Walter Fiers
Tumor necrosis factor and interleukin 1 activate phospholipase in rat chondrocytes.
FEBS letters 1988;232(1):24-8.
1988: Marc Mareel; Frans van Roy; Erik Bruyneel; J Bolscher; D Schallier; M de Mets
Molecular biology of minimal invasion.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1988;106():14-20.
1987: P Suffys; Rudi Beyaert; Frans van Roy; Walter Fiers
Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism.
Biochemical and biophysical research communications 1987;149(2):735-43.
1987: Walter Fiers; Rudi Beyaert; Peter Brouckaert; B Everaert; P Suffys; Jan Tavernier; B Van Haesebroeck; Frans van Roy
Tumor necrosis factor: a potential antitumor agent?
Journal of interferon research 1987;7(5):627-34.
1987: J Gao; Frans van Roy; Ludwine MESSIAEN; J Cosaert; G Liebaut; P Coopman; Walter Fiers; Marc Mareel
Pathology of tumours produced in syngeneic Fischer rats by fibroblast-like cells before and after transfection with oncogenes.
Pathology, research and practice 1987;182(1):48-57.
1987: Walter Fiers; Peter Brouckaert; A L Goldberg; I Kettelhut; P Suffys; Jan Tavernier; B Vanhaesebroeck; Frans van Roy
Structure-function relationship of tumour necrosis factor and its mechanism of action.
Ciba Foundation symposium 1987;131():109-23.
1986: Frans van Roy; Ludwine MESSIAEN; G Liebaut; J Gao; C H Dragonetti; Walter Fiers; Marc M Mareel
Invasiveness and metastatic capability of rat fibroblast-like cells before and after transfection with immortalizing and transforming genes.
Cancer research 1986;46(9):4787-95.