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Jean Boutin

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Benjamin Fould; Sophie-Penelope Guenin; Véronique Lamamy; C Ouvry; Jean A Boutin; Francis Cogé; Gilles Ferry
Mutagenic analysis in a pure molecular system shows that thioredoxin-interacting protein residue Cys247 is necessary and sufficient for a mixed disulfide formation with thioredoxin.
Séverine Devavry; Céline Legros; Benoît Malpaux; Jean A Boutin; Chantal Brasseur; William Cohen; Philippe Delagrange; Gilberto Spadoni; Olivier Nosjean
Description of the constitutive activity of cloned human melatonin receptors hMT(1) and hMT(2) and discovery of inverse agonists.
Mohamed Ettaoussi; Marouan Rami; Pierre Renard; Ahmed Sabaouni; Michael Spedding; Pascal Berthelot; Jean A Boutin; Daniel-Henri Caignard; Philippe Delagrange; Saïd Yous
Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).

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2012: Benjamin Fould; Sophie-Penelope Guenin; Véronique Lamamy; C Ouvry; Jean A Boutin; Francis Cogé; Gilles Ferry
Mutagenic analysis in a pure molecular system shows that thioredoxin-interacting protein residue Cys247 is necessary and sufficient for a mixed disulfide formation with thioredoxin.
Protein science : a publication of the Protein Society 2012;21(9):1323-33.
2012: Séverine Devavry; Céline Legros; Benoît Malpaux; Jean A Boutin; Chantal Brasseur; William Cohen; Philippe Delagrange; Gilberto Spadoni; Olivier Nosjean
Description of the constitutive activity of cloned human melatonin receptors hMT(1) and hMT(2) and discovery of inverse agonists.
Journal of pineal research 2012;53(1):29-37.
2012: Mohamed Ettaoussi; Marouan Rami; Pierre Renard; Ahmed Sabaouni; Michael Spedding; Pascal Berthelot; Jean A Boutin; Daniel-Henri Caignard; Philippe Delagrange; Saïd Yous
Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).
European journal of medicinal chemistry 2012;49():310-23.
2012: Mark J Millan; O Muller; Adrian Newman-Tancredi; Clotilde Mannoury La Cour; Philippe Marin; Valérie Audinot; Joël Bockaert; Jean A Boutin; Benjamin Chanrion; Didier Cussac; Anne Dekeyne; Benjamin Di Cara; Delphine S Dupuis; Ralf JOckers; Maud Kamal; Gilbert Lavielle
S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization.
The Journal of pharmacology and experimental therapeutics 2012;340(3):750-64.
2012: Séverine Devavry; Sophie-Pénélope Guenin; Céline Legros; Benoît Malpaux; Olivier Nosjean; C Ouvry; Chantal Brasseur; Francis Cogé; William Cohen; Philippe Delagrange; Jean A Boutin
Molecular pharmacology of the mouse melatonin receptors MT₁ and MT₂.
European journal of pharmacology 2012;677(1-3):15-21.
2012: Odile Della Zuana; Alain Ktorza; Viviane Levenez; Jean-Louis Nahon; F Presse; Valérie Audinot; Jean A Boutin
Peripheral injections of melanin-concentrating hormone receptor 1 antagonist S38151 decrease food intake and body weight in rodent obesity models.
Frontiers in endocrinology 2012;3():160.
2011: Olivier Le Marec; Benjamin Lefranc; Jean A Boutin; Jean Costentin; Jean-Claude Do-Régo; Christophe Dubessy; Cindy Neveu; Manuel Tena-Sempere; Marie-Christine Tonon; Hubert Vaudry; Jérôme Leprince
Structure-activity relationships of a series of analogues of the RFamide-related peptide 26RFa.
Journal of medicinal chemistry 2011;54(13):4806-14.
2011: Christophe Mésangeau; Mikaël Fraise; Philippe Delagrange; Daniel-Henri Caignard; Jean A Boutin; Pascal Berthelot; Saïd Yous
Preparation and pharmacological evaluation of a novel series of 2-(phenylthio)benzo[b]thiophenes as selective MT2 receptor ligands.
European journal of medicinal chemistry 2011;46(5):1835-40.
2011: Véronique Leclerc; Mohamed Ettaoussi; Marouan Rami; Amaury Farce; Jean A Boutin; Philippe Delagrange; Daniel-Henri Caignard; Pierre Renard; Pascal Berthelot; Saïd Yous
Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3.
European journal of medicinal chemistry 2011;46(5):1622-9.
2011: Isabelle Pevet; Cédric Brulé; André Tizot; Arnaud Gohier; Francisco Cruzalegui; Jean A Boutin; Solo Goldstein
Synthesis and pharmacological evaluation of thieno[2,3-b]pyridine derivatives as novel c-Src inhibitors.
Bioorganic & medicinal chemistry 2011;19(8):2517-28.
2011: Matthieu Jeanty; Franck Suzenet; Philippe Delagrange; Olivier Nosjean; Jean A Boutin; Daniel-Henri Caignard; Gérald Guillaumet
Design and synthesis of 1-(2-alkanamidoethyl)-6-methoxy-7-azaindole derivatives as potent melatonin agonists.
Bioorganic & medicinal chemistry letters 2011;21(8):2316-9.
2011: Florence Sancier; Aurélie Dumont; Audrey Sirvent; Ludmilla Paquay de Plater; Thomas Edmonds; Géraldine David; Michel Jan; Catherine de Montrion; Francis Cogé; Stéphane Léonce; Michael Burbridge; Alain Bruno; Jean A Boutin; Brian Lockhart; Serge Roche; Francisco Cruzalegui
Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells.
PloS one 2011;6(2):e17237.
2010: Mélanie Liutkus; Frédéric Caijo; Anne-Lise Girard; Erwan Ayral; Valérie Audinot; Jean A Boutin; Pierre Renard; Daniel-Henri Caignard; Catherine Dacquet; Alain Ktorza; Paul Mosset; René Grée
Synthesis of new 8(S)-HETE analogs and their biological evaluation as activators of the PPAR nuclear receptors.
Journal of enzyme inhibition and medicinal chemistry 2010;25(5):653-72.
2010: Charles-Etienne Benoit; Stephane Bastianetto; Jonathan Brouillette; YiuChung Tse; Jean A Boutin; Philippe Delagrange; TakPan Wong; Philippe Sarret; Rémi Quirion
Loss of quinone reductase 2 function selectively facilitates learning behaviors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(38):12690-700.
2010: Jean-Pierre Cabaniols; C Ouvry; Véronique Lamamy; Isabelle Fery; Marie-Laure Craplet; Natacha Moulharat; Sophie-Pénélope Guenin; Stéphane Bedut; Olivier Nosjean; Gilles Ferry; Séverine Devavry; Cécile Jacqmarcq; Céline Lebuhotel; Luc Mathis; Christophe Delenda; Jean A Boutin; Philippe Duchâteau; Francis Cogé; Frédéric Pâques
Meganuclease-driven targeted integration in CHO-K1 cells for the fast generation of HTS-compatible cell-based assays.
Journal of biomolecular screening 2010;15(8):956-67.
2010: Gilles Ferry; Sabrina Hecht; Sylvie Berger; Natacha Moulharat; F Coge; Gérald Guillaumet; Véronique Leclerc; Saïd Yous; Philippe Delagrange; Jean A Boutin
Old and new inhibitors of quinone reductase 2.
Chemico-biological interactions 2010;186(2):103-9.
2010: Christophe Mésangeau; Basile Pérès; Carole Descamps-François; Philippe CHAVATTE; Valérie Audinot; Sophie Coumailleau; Jean A Boutin; Philippe Delagrange; Caroline Bennejean; Pierre Renard; Daniel-Henri Caignard; Pascal Berthelot; Saïd Yous
Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands.
Bioorganic & medicinal chemistry 2010;18(10):3426-36.
2010: Ludwig Vincent; William Cohen; Philippe Delagrange; Jean A Boutin; Olivier Nosjean
Molecular and cellular pharmacological properties of 5-methoxycarbonylamino-N-acetyltryptamine (MCA-NAT): a nonspecific MT3 ligand.
Journal of pineal research 2010;48(3):222-9.
2010: Mette G Sørensen; Morten A Karsdal; Morten Hanefeld Dziegiel; Jean A Boutin; Olivier Nosjean; Kim Henriksen
Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption.
BMC musculoskeletal disorders 2010;11():250.
2009: Valérie Audinot; Odile Della Zuana; Nelly Fabry; C Ouvry; Olivier Nosjean; JM Henlin; Jean-Luc Fauchère; Jean A Boutin
S38151 [p-guanidinobenzoyl-[Des-Gly(10)]-MCH(7-17)] is a potent and selective antagonist at the MCH(1) receptor and has anti-feeding properties in vivo.
Peptides 2009;30(11):1997-2007.
2009: Jean A Boutin; Gilles Ferry
Autotaxin.
Cellular and molecular life sciences : CMLS 2009;66(18):3009-21.
2009: Marc Litaudon; Claire Jolly; Catherine Le Callonec; Dao Din Cuong; Pascal Retailleau; Olivier Nosjean; Van Hung Nguyen; Bruno Pfeiffer; Jean A Boutin; Françoise Guéritte
Cytotoxic pentacyclic triterpenoids from Combretum sundaicum and Lantana camara as inhibitors of Bcl-xL/BakBH3 domain peptide interaction.
Journal of natural products 2009;72(7):1314-20.
2009: Mathias Antoine; Jean A Boutin; Gilles Ferry
Binding kinetics of glucose and allosteric activators to human glucokinase reveal multiple conformational states.
Biochemistry 2009;48(23):5466-82.
2009: Cécile Parmenon; Jérôme Guillard; Daniel-Henri Caignard; Nathalie Hennuyer; Bart Staels; Valérie Audinot-Bouchez; Jean A Boutin; Catherine Dacquet; Alain Ktorza; Marie-Claude Viaud-Massuard
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.
Bioorganic & medicinal chemistry letters 2009;19(10):2683-7.
2009: Marc Litaudon; Hadjira Bousserouel; Khalijah Awang; Olivier Nosjean; Marie-Thérèse Martin; Marie Elise Tran Huu Dau; Hamid A Hadi; Jean A Boutin; Thierry Sévenet; Françoise Guéritte
A Dimeric sesquiterpenoid from a Malaysian Meiogyne as a new inhibitor of Bcl-xL/BakBH3 domain peptide interaction.
Journal of natural products 2009;72(3):480-3.
2008: Gilles Ferry; Natacha Moulharat; Jean-Philippe Pradère; Patrice Desos; Anne Try; Annie Genton; Adeline Giganti; Monique Beucher-Gaudin; Michel Lonchampt; Marc Bertrand; Jean Sébastien Saulnier-Blache; Gordon C Tucker; Alex Cordi; Jean A Boutin
S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool.
The Journal of pharmacology and experimental therapeutics 2008;327(3):809-19.
2008: Jean A Boutin; Estelle Marcheteau; Philippe Hennig; Natacha Moulharat; Sylvie Berger; Philippe Delagrange; Jean-Paul Bouchet; Gilles Ferry
MT3/QR2 melatonin binding site does not use melatonin as a substrate or a co-substrate.
Journal of pineal research 2008;45(4):524-31.
2008: Sophie Poissonnier-Durieux; Mohamed Ettaoussi; Basile Pérès; Jean A Boutin; Valérie Audinot; Caroline Bennejean; Philippe Delagrange; Daniel-Henri Caignard; Pierre Renard; Pascal Berthelot; Daniel Lesieur; Saïd Yous
Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands.
Bioorganic & medicinal chemistry 2008;16(18):8339-48.
2008: Jean A Boutin; Carine Saunier; Sophie-Pénélope Guenin; Sylvie Berger; Natacha Moulharat; Arnaud Gohier; Philippe Delagrange; Francis Cogé; Gilles Ferry
Studies of the melatonin binding site location onto quinone reductase 2 by directed mutagenesis.
Archives of biochemistry and biophysics 2008;477(1):12-9.
2008: Marie-Anne Letellier; Jérôme Guillard; Daniel-Henri Caignard; Gilles Ferry; Jean A Boutin; Marie-Claude Viaud-Massuard
Synthesis of potential Rho-kinase inhibitors based on the chemistry of an original heterocycle: 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one.
European journal of medicinal chemistry 2008;43(8):1730-6.
2008: Valérie Audinot; Anne Bonnaud; Line Grandcolas; Marianne Rodriguez; Nadine Nagel; Jean-Pierre Galizzi; Ales Balik; Sophie Messager; David G Hazlerigg; Perry Barrett; Philippe Delagrange; Jean A Boutin
Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors.
Biochemical pharmacology 2008;75(10):2007-19.
2008: Natacha Moulharat; Benjamin Fould; Adeline Giganti; Jean A Boutin; Gilles Ferry
Molecular pharmacology of adipocyte-secreted autotaxin.
Chemico-biological interactions 2008;172(2):115-24.
2008: Adeline Giganti; Marianne Rodriguez; Benjamin Fould; Natacha Moulharat; Francis Cogé; Pascale Chomarat; Jean-Pierre Galizzi; Philippe Valet; Jean Sébastien Saulnier-Blache; Jean A Boutin; Gilles Ferry
Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization.
The Journal of biological chemistry 2008;283(12):7776-89.
2008: Cécile Parmenon; Jérôme Guillard; Daniel-Henri Caignard; Nathalie Hennuyer; Bart Staels; Valérie Audinot-Bouchez; Jean A Boutin; Catherine Dacquet; Alain Ktorza; Marie-Claude Viaud-Massuard
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation.
Bioorganic & medicinal chemistry letters 2008;18(5):1617-22.
2007: Pascale Chomarat; Francis Cogé; Sophie-Pénélope Guénin; François Mailliet; Fanny Vella; Catherine Mallet; Stéphanie Giraudet; Nadine Nagel; stephane leonce; Gilles Ferry; Philippe Delagrange; Jean A Boutin
Cellular knock-down of quinone reductase 2: a laborious road to successful inhibition by RNA interference.
Biochimie 2007;89(10):1264-75.
2007: Gilles Ferry; Adeline Giganti; Francis Cogé; Fabien Bertaux; Kader Thiam; Jean A Boutin
Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal.
FEBS letters 2007;581(18):3572-8.
2007: Nicolas Chartrel; ALVEAR-PEREZ RODRIGO; Jérôme Leprince; Xavier Iturrioz; Annabelle Reaux-Le Goazigo; Valérie Audinot; Pascale Chomarat; F Coge; Olivier Nosjean; M Rodriguez; Jean-Pierre Galizzi; Jean A Boutin; Hubert Vaudry; Catherine Llorens-Cortes
Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".
Science (New York, N.Y.) 2007;315(5813):766; author reply 766.
2007: Catherine Thollon; S Bedut; Nicole Villeneuve; Francis Cogé; L Piffard; J-P Guillaumin; C Brunel-Jacquemin; Pascale Chomarat; Jean A Boutin; Jean-Louis Peglion; Jean-Paul Vilaine
Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity.
British journal of pharmacology 2007;150(1):37-46.
2006: Olivier Nosjean; Sophie Souchaud; Clarisse Deniau; Olivier Geneste; Nicolas Cauquil; Jean A Boutin
A simple theoretical model for fluorescence polarization binding assay development.
Journal of biomolecular screening 2006;11(8):949-58.
2006: C Allera-Moreau; Pascale Chomarat; Valérie Audinot; Francis Cogé; M Gillard; Y Martineau; Jean A Boutin; Anne-Catherine Prats
The use of IRES-based bicistronic vectors allows the stable expression of recombinant G-protein coupled receptors such as NPY5 and histamine 4.
Biochimie 2006;88(6):737-46.
2006: Julien MOZO; Gilles Ferry; Sandrine Masscheleyn; Bruno Miroux; Jean A Boutin; Frederic Bouillaud
Assessment of a high-throughput screening methodology for the measurement of purified UCP1 uncoupling activity.
Analytical biochemistry 2006;351(2):201-6.
2006: Julien MOZO; Gilles Ferry; Aurélie Studeny; Claire Pecqueur; Marianne Rodriguez; Jean A Boutin; Frederic Bouillaud
Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose.
The Biochemical journal 2006;393(Pt 1):431-9.
2005: François Mailliet; Gilles Ferry; Fanny Vella; Sylvie Berger; Francis Cogé; Pascale Chomarat; Catherine Mallet; Sophie-Pénélope Guénin; Gérald Guillaumet; Marie-Claude Viaud-Massuard; Saïd Yous; Philippe Delagrange; Jean A Boutin
Characterization of the melatoninergic MT3 binding site on the NRH:quinone oxidoreductase 2 enzyme.
Biochemical pharmacology 2005;71(1-2):74-88.
2005: Fanny Vella; Gilles Ferry; Philippe Delagrange; Jean A Boutin
NRH:quinone reductase 2: an enzyme of surprises and mysteries.
Biochemical pharmacology 2005;71(1-2):1-12.
2005: AF Soares; Olivier Nosjean; D Cozzone; D D'Orazio; M Becchi; Michel Guichardant; G Ferry; Jean A Boutin; Michel Lagarde; A Géloën
Covalent binding of 15-deoxy-delta12,14-prostaglandin J2 to PPARgamma.
Biochemical and biophysical research communications 2005;337(2):521-5.
2005: Frédéric De Ceuninck; Estelle Marcheteau; Sylvie Berger; Audrey Caliez; Valérie Dumont; Martine Raes; Philippe Anract; Grégory Leclerc; Jean A Boutin; Gilles Ferry
Assessment of some tools for the characterization of the human osteoarthritic cartilage proteome.
Journal of biomolecular techniques : JBT 2005;16(3):256-65.
2005: Jean A Boutin; Valérie Audinot; Gilles Ferry; Philippe Delagrange
Molecular tools to study melatonin pathways and actions.
Trends in pharmacological sciences 2005;26(8):412-9.
2005: Gilles Ferry; Caroline Ubeaud; Pierre-Hervé Lambert; Sophie Bertin; Francis Cogé; Pascale Chomarat; Philippe Delagrange; Bernard Serkiz; Jean-Paul Bouchet; Roger J W Truscott; Jean A Boutin
Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase.
The Biochemical journal 2005;388(Pt 1):205-15.
2005: Philippe Beauverger; Marianne Rodriguez; Jean-Paul Nicolas; Valérie Audinot; Véronique Lamamy; Sandra Dromaint; Nadine Nagel; Christelle Macia; Odile Léopold; Jean-Pierre Galizzi; Daniel-Henri Caignard; Ignacio Aldana; Antonio Monge; Pascale Chomarat; Jean A Boutin
Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay.
Cellular signalling 2005;17(4):489-96.
2005: Jeremie Boucher; Didier Quilliot; J P Pradères; Marie-Françoise Simon; Sandra Grès; Charlotte Guigné; Danielle Prévot; Gilles Ferry; Jean A Boutin; Christian Carpéné; Philippe Valet; Jean Sébastien Saulnier-Blache
Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression.
Diabetologia 2005;48(3):569-77.
2005: Jean A Boutin; Florence Chatelain-Egger; Fanny Vella; Philippe Delagrange; Gilles Ferry
Quinone reductase 2 substrate specificity and inhibition pharmacology.
Chemico-biological interactions 2005;151(3):213-28.
2004: François Mailliet; Gilles Ferry; Fanny Vella; Kader Thiam; Philippe Delagrange; Jean A Boutin
Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT3.
FEBS letters 2004;578(1-2):116-20.
2004: Gilles Ferry; Caroline Ubeaud; Claire Dauly; Julien MOZO; Sophie Guillard; Sylvie Berger; Sandrine Jimenez; Catherine Scoul; Gregory Leclerc; Saïd Yous; Philippe Delagrange; Jean A Boutin
Purification of the recombinant human serotonin N-acetyltransferase (EC 2.3.1.87): further characterization of and comparison with AANAT from other species.
Protein expression and purification 2004;38(1):84-98.
2004: Bruno Cardinaud; Fleur Darré-Toulemonde; Jacques Duhault; Jean A Boutin; Jean-Louis Nahon
Comparative analysis of melanin-concentrating hormone structure and activity in fishes and mammals.
Peptides 2004;25(10):1623-32.
2004: Carlos Larraya; Jérôme Guillard; Pierre Renard; Valérie Audinot; Jean A Boutin; Philippe Delagrange; Caroline Bennejean; Marie-Claude Viaud-Massuard
Preparation of 4-azaindole and 7-azaindole dimers with a bisalkoxyalkyl spacer in order to preferentially target melatonin MT1 receptors over melatonin MT2 receptors.
European journal of medicinal chemistry 2004;39(6):515-26.
2004: David Alagille; Bruno Pfeiffer; Elizabeth Scalbert; Gilles Ferry; Jean A Boutin; Pierre Renard; Marie-Claude Viaud-Massuard
Design and synthesis of indole and tetrahydroisoquinoline hydantoin derivatives as human chymase inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2004;19(2):137-43.
2004: Odile Della Zuana; L Revereault; Annette G Beck-Sickinger; A Monge; Daniel-Henri Caignard; Jean-Luc Fauchère; JM Henlin; Valérie Audinot; Jean A Boutin; S Chamorro; Michel Félétou; Nigel Levens
A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(4):628-39.
2004: François Mailliet; Valérie Audinot; Benoît Malpaux; Anne Bonnaud; Philippe Delagrange; Martine Migaud; Perry Barrett; Marie-Claude Viaud-Massuard; Daniel Lesieur; François Lefoulon; Pierre Renard; Jean A Boutin
Molecular pharmacology of the ovine melatonin receptor: comparison with recombinant human MT1 and MT2 receptors.
Biochemical pharmacology 2004;67(4):667-77.
2004: Gilles Ferry; Caroline Ubeaud; Julien MOZO; Christophe Péan; Philippe Hennig; Marianne Rodriguez; Catherine Scoul; Anne Bonnaud; Olivier Nosjean; Jean-Pierre Galizzi; Philippe Delagrange; Pierre Renard; Jean-Paul Volland; Saïd Yous; Daniel Lesieur; Jean A Boutin
New substrate analogues of human serotonin N-acetyltransferase produce in situ specific and potent inhibitors.
European journal of biochemistry / FEBS 2004;271(2):418-28.
2003: Franck B Riquet; Marianne Rodriguez; Nolwen Guigal; Sandra Dromaint; Isabelle Naime; Jean A Boutin; Jean-Pierre Galizzi
In vivo characterisation of the human UCP3 gene minimal promoter in mice tibialis anterior muscles.
Biochemical and biophysical research communications 2003;311(3):583-91.
2003: Christelle Mérial-Kieny; Michel Lonchampt; Francis Cogé; Patrick Verwaerde; Jean-Pierre Galizzi; Jean A Boutin; Max Lafontan; Nigel Levens; Jean Galitzky; Michel Félétou
Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes.
British journal of pharmacology 2003;139(5):935-44.
2003: Valérie Audinot; François Mailliet; Chantal Lahaye-Brasseur; Anne Bonnaud; Aude Le Gall; Christophe Amossé; Sandra Dromaint; Marianne Rodriguez; Nadine Nagel; Jean-Pierre Galizzi; Benoît Malpaux; Gérald Guillaumet; Daniel Lesieur; François Lefoulon; Pierre Renard; Philippe Delagrange; Jean A Boutin
New selective ligands of human cloned melatonin MT1 and MT2 receptors.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(6):553-61.
2003: Gilles Ferry; Edwige Tellier; Anne Try; Sandra Grés; Isabelle Naime; Marie-Françoise Simon; Marianne Rodriguez; Jeremie Boucher; Ivan Tack; Stephane Gesta; Pascale Chomarat; Marc Dieu; Martine Raes; Jean-Pierre Galizzi; Philippe Valet; Jean A Boutin; Jean Sébastien Saulnier-Blache
Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity.
The Journal of biological chemistry 2003;278(20):18162-9.
2003: Isabelle Charton; Franck Suzenet; Jean A Boutin; Valérie Audinot; Philippe Delagrange; Caroline Bennejean; Pierre Renard; Gérald Guillaumet
Synthesis of 5-substituted-2,3-dihydro-1,4-benzoxathiins: biological evaluation as melatonin receptors ligands.
Journal of enzyme inhibition and medicinal chemistry 2003;18(2):187-93.
2003: C Mesangeau; Saïd Yous; Philippe CHAVATTE; Gilles Ferry; Valérie Audinot; Jean A Boutin; Philippe Delagrange; Caroline Bennejean; Pierre Renard; Daniel Lesieur
Design, synthesis and in vitro evaluation of novel benzo[b]thiophene derivatives as serotonin N-acetyltransferase (AANAT) inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2003;18(2):119-25.
2003: Carole Descamps-François; Saïd Yous; Philippe CHAVATTE; Valérie Audinot; Anne Bonnaud; Jean A Boutin; Philippe Delagrange; Caroline Bennejean; Pierre Renard; Daniel Lesieur
Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands.
Journal of medicinal chemistry 2003;46(7):1127-9.
2003: Cécile Pégurier; Laurence Morellato; Eminn Chahed; Jean Andrieux; Jean-Paul Nicolas; Jean A Boutin; Caroline Bennejean; Philippe Delagrange; Michel Langlois; Monique Mathé-Allainmat
Synthesis of new arylalkoxy amido derivatives as melatoninergic ligands.
Bioorganic & medicinal chemistry 2003;11(5):789-800.
2003: Saïd Yous; Sophie Durieux-Poissonnier; Emmanuelle Lipka-Belloli; Halim Guelzim; Christophe Bochu; Valérie Audinot; Jean A Boutin; Philippe Delagrange; Caroline Bennejean; Pierre Renard; Daniel Lesieur
Design and synthesis of 3-phenyl tetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands.
Bioorganic & medicinal chemistry 2003;11(5):753-9.
2003: Marianne Rodriguez; Valérie Audinot; Sandra Dromaint; Christelle Macia; Véronique Lamamy; Philippe Beauverger; Herve RIQUE; Jérôme Imbert; Jean-Paul Nicolas; Jean A Boutin; Jean-Pierre Galizzi
Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform.
The Biochemical journal 2003;369(Pt 3):667-73.
2002: Nolwen Guigal; Marianne Rodriguez; Raquel N Cooper; Sandra Dromaint; James P Di Santo; Vincent Mouly; Jean A Boutin; Jean-Pierre Galizzi
Uncoupling protein-3 (UCP3) mRNA expression in reconstituted human muscle after myoblast transplantation in RAG2-/-/gamma c/C5(-) immunodeficient mice.
The Journal of biological chemistry 2002;277(49):47407-11.
2002: N Beaurain; C Mésangeau; Philippe CHAVATTE; Gilles Ferry; Valérie Audinot; Jean A Boutin; Philippe Delagrange; Caroline Bennejean; Saïd Yous
Design, synthesis and in vitro evaluation of novel derivatives as serotonin N-acetyltransferase inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2002;17(6):409-14.
2002: Adrian Newman-Tancredi; Didier Cussac; Valérie Audinot; Jean-Paul Nicolas; Frédéric De Ceuninck; Jean A Boutin; Mark J Millan
Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor.
The Journal of pharmacology and experimental therapeutics 2002;303(2):805-14.
2002: Mark J Millan; Lisa Maiofiss; Didier Cussac; Valérie Audinot; Jean A Boutin; Adrian Newman-Tancredi
Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.
The Journal of pharmacology and experimental therapeutics 2002;303(2):791-804.
2002: Valérie Audinot; Nelly Fabry; Jean-Paul Nicolas; Philippe Beauverger; Adrian Newman-Tancredi; Mark J Millan; Anne Try; Frédéric Bornancin; Emmanuel Canet; Jean A Boutin
Ligand modulation of [35S]GTPgammaS binding at human alpha(2A), alpha(2B) and alpha(2C) adrenoceptors.
Cellular signalling 2002;14(10):829-37.
2002: Gilles Ferry; Julien MOZO; Caroline Ubeaud; S Berger; M Bertrand; Anne Try; Philippe Beauverger; C Mesangeau; Philippe Delagrange; Jean A Boutin
Characterization and regulation of a CHO cell line stably expressing human serotonin N-acetyltransferase (EC 2.3.1.87).
Cellular and molecular life sciences : CMLS 2002;59(8):1395-405.
2002: Laurence Maulon-Feraille; Odile Della Zuana; Thomas Suply; Carole Rovere-Jovene; Valérie Audinot; Nigel Levens; Jean A Boutin; Jacques Duhault; Jean-Louis Nahon
Appetite-boosting property of pro-melanin-concentrating hormone(131-165) (neuropeptide-glutamic acid-isoleucine) is associated with proteolytic resistance.
The Journal of pharmacology and experimental therapeutics 2002;302(2):766-73.
2002: Valérie Audinot; Chantal Lahaye; Thomas Suply; Carole Rovère-Jovène; Marianne Rodriguez; Jean-Paul Nicolas; Philippe Beauverger; Bruno Cardinaud; Jean-Pierre Galizzi; Jean-Luc Fauchère; Jean-Louis Nahon; Jean A Boutin
SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.
Biochemical and biophysical research communications 2002;295(4):841-8.
2002: Olivier Nosjean; Jean A Boutin
Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part?
Cellular signalling 2002;14(7):573-83.
2002: Valérie Wallez; Sophie Durieux-Poissonnier; Philippe CHAVATTE; Jean A Boutin; Valérie Audinot; Jean-Paul Nicolas; Caroline Bennejean; Philippe Delagrange; Pierre Renard; Daniel Lesieur
Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands.
Journal of medicinal chemistry 2002;45(13):2788-800.
2002: Jean A Boutin; Thomas Suply; Valérie Audinot; Marianne Rodriguez; Philippe Beauverger; Jean-Paul Nicolas; Jean-Pierre Galizzi; Jean-Luc Fauchère
Melanin-concentrating hormone and its receptors: state of the art.
Canadian journal of physiology and pharmacology 2002;80(5):388-95.
2002: Véronique Leclerc; Saïd Yous; Philippe Delagrange; Jean A Boutin; Pierre Renard; Daniel Lesieur
Synthesis of nitroindole derivatives with high affinity and selectivity for melatoninergic binding sites MT(3).
Journal of medicinal chemistry 2002;45(9):1853-9.
2002: Mike Burbridge; Francis Cogé; Jean-Pierre Galizzi; Jean A Boutin; D C West; Gordon C Tucker
The role of the matrix metalloproteinases during in vitro vessel formation.
Angiogenesis 2002;5(3):215-26.
2001: Gilles Ferry; L Gillet; V Bruneau; J M Banales; Philippe Beauverger; Francis Cogé; Jean-Pierre Galizzi; Elizabeth Scalbert; T Okamoto; H Urata; Jean A Boutin
Development of new assays and improved procedures for the purification of recombinant human chymase.
European journal of biochemistry / FEBS 2001;268(22):5885-93.
2001: Marianne Rodriguez; Philippe Beauverger; Isabelle Naime; Herve RIQUE; C Ouvry; S Souchaud; Sandra Dromaint; Nadine Nagel; Thomas Suply; Valérie Audinot; Jean A Boutin; Jean-Pierre Galizzi
Cloning and molecular characterization of the novel human melanin-concentrating hormone receptor MCH2.
Molecular pharmacology 2001;60(4):632-9.
2001: Thomas Suply; Odile Della Zuana; Valérie Audinot; Marianne Rodriguez; Philippe Beauverger; Jacques Duhault; Emmanuel Canet; Jean-Pierre Galizzi; Jean-Louis Nahon; Nigel Levens; Jean A Boutin
SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study.
The Journal of pharmacology and experimental therapeutics 2001;299(1):137-46.
2001: Surajit Ganguly; JA Gastel; joan weller; C Schwartz; H Jaffe; MA Namboodiri; Steven L Coon; Alison Burgess Hickman; Mark D Rollag; Tomas Obsil; Philippe Beauverger; Gilles Ferry; Jean A Boutin; David Klein
Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):8083-8.
2001: Michel Feletou; Michel Lonchampt; F Coge; Jean-Pierre Galizzi; C Bassoullet; C Merial; P Robineau; Jean A Boutin; P L Huang; Paul M Vanhoutte; Emmanuel Canet
Regulation of murine airway responsiveness by endothelial nitric oxide synthase.
American journal of physiology. Lung cellular and molecular physiology 2001;281(1):L258-67.
2001: Francis Cogé; Sophie-Pénélope Guénin; Herve RIQUE; Jean A Boutin; Jean-Pierre Galizzi
Structure and expression of the human histamine H4-receptor gene.
Biochemical and biophysical research communications 2001;284(2):301-9.
2001: Valérie Audinot; Chantal Lahaye; Thomas Suply; Philippe Beauverger; Marianne Rodriguez; Jean-Pierre Galizzi; Jean-Luc Fauchère; Jean A Boutin
[125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor.
British journal of pharmacology 2001;133(3):371-8.
2001: Mark J Millan; Didier Cussac; G Milligan; C Carr; Valérie Audinot; Alain Gobert; Françoise Lejeune; Jean-Michel Rivet; Mauricette Brocco; Delphine Duqueyroix; Jean-Paul Nicolas; Jean A Boutin; Adrian Newman-Tancredi
Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization.
The Journal of pharmacology and experimental therapeutics 2001;297(3):876-87.
2001: Olivier Nosjean; J P Nicolas; F Klupsch; Philippe Delagrange; Emmanuel Canet; Jean A Boutin
Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 .
Biochemical pharmacology 2001;61(11):1369-79.
2001: JM Henlin; Jean A Boutin; F Duchêne-Roger; Jean-Paul Nicolas; C Desmet-Beaufort; Nigel Levens; Jean-Luc Fauchère
Parallel synthesis and pharmacological screening of nonpeptide ligands of the neuropeptide Y receptor subtype Y5.
The journal of peptide research : official journal of the American Peptide Society 2001;57(5):419-27.
2001: Valérie Audinot; Philippe Beauverger; Chantal Lahaye; Thomas Suply; Marianne Rodriguez; C Ouvry; Véronique Lamamy; Jérôme Imbert; Herve RIQUE; Jean-Louis Nahon; Jean-Pierre Galizzi; Emmanuel Canet; Nigel Levens; JL Fauchere; Jean A Boutin
Structure-activity relationship studies of melanin-concentrating hormone (MCH)-related peptide ligands at SLC-1, the human MCH receptor.
The Journal of biological chemistry 2001;276(17):13554-62.
2001: Francis Cogé; Sophie-Pénélope Guénin; Valérie Audinot; A Renouard-Try; Philippe Beauverger; Christelle Macia; C Ouvry; Nadine Nagel; Herve RIQUE; Jean A Boutin; Jean-Pierre Galizzi
Genomic organization and characterization of splice variants of the human histamine H3 receptor.
The Biochemical journal 2001;355(Pt 2):279-88.
2001: Gilles Ferry; V Bruneau; Philippe Beauverger; M Goussard; Marianne Rodriguez; Véronique Lamamy; Sandra Dromaint; Emmanuel Canet; Jean-Pierre Galizzi; Jean A Boutin
Binding of prostaglandins to human PPARgamma: tool assessment and new natural ligands.
European journal of pharmacology 2001;417(1-2):77-89.
2001: JM Henlin; Jean A Boutin; Nathalie Kucharczyk; C Desmet-Beaufort; Armelle Loynel; M Bertrand; Annie Genton; Gordon C Tucker; Ghanem Atassi; J L Fauchére
From peptide libraries to optimized nonpeptide ligands in the search for S-farnesyltransferase inhibitors.
The journal of peptide research : official journal of the American Peptide Society 2001;57(2):85-96.
2001: Odile Della Zuana; M Sadlo; M Germain; Michel Félétou; S Chamorro; F Tisserand; C de Montrion; J F Boivin; Jacques Duhault; Jean A Boutin; Nigel Levens
Reduced food intake in response to CGP 71683A may be due to mechanisms other than NPY Y5 receptor blockade.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(1):84-94.
2000: Mark J Millan; Anne Dekeyne; Adrian Newman-Tancredi; Didier Cussac; Valérie Audinot; G Milligan; Delphine Duqueyroix; Sylvie Girardon; J Mullot; Jean A Boutin; Jean-Paul Nicolas; A Renouard-Try; Jean-Michel Lacoste; Alex Cordi
S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine.
The Journal of pharmacology and experimental therapeutics 2000;295(3):1192-205.
2000: C Jellimann; Monique Mathé-Allainmat; Jean Andrieux; S Kloubert; Jean A Boutin; Jean-Paul Nicolas; Caroline Bennejean; Philippe Delagrange; Michel Langlois
Synthesis of phenalene and acenaphthene derivatives as new conformationally restricted ligands for melatonin receptors.
Journal of medicinal chemistry 2000;43(22):4051-62.
2000: Olivier Nosjean; M Ferro; F Coge; Philippe Beauverger; JM Henlin; François Lefoulon; JL Fauchere; Philippe Delagrange; Emmanuel Canet; Jean A Boutin
Identification of the melatonin-binding site MT3 as the quinone reductase 2.
The Journal of biological chemistry 2000;275(40):31311-7.
2000: Gilles Ferry; Jean A Boutin
High-capacity screening of arylalkylamine N-acetyltransferase inhibitors using a high-performance liquid chromatography system.
Journal of biomolecular screening 2000;5(5):361-8.
2000: Gilles Ferry; Armelle Loynel; Nathalie Kucharczyk; Sophie Bertin; Marianne Rodriguez; Philippe Delagrange; Jean-Pierre Galizzi; E Jacoby; Jean-Paul Volland; Daniel Lesieur; Pierre Renard; Emmanuel Canet; Jean-Luc Fauchère; Jean A Boutin
Substrate specificity and inhibition studies of human serotonin N-acetyltransferase.
The Journal of biological chemistry 2000;275(12):8794-805.
2000: Jacques Duhault; Michelle Boulanger; S Chamorro; Jean A Boutin; Odile Della Zuana; E Douillet; Jean-Luc Fauchère; Michel Félétou; M Germain; B Husson; A M Vega; Pierre Renard; F Tisserand
Food intake regulation in rodents: Y5 or Y1 NPY receptors or both?
Canadian journal of physiology and pharmacology 2000;78(2):173-85.
2000: Mark J Millan; Adrian Newman-Tancredi; Valérie Audinot; Didier Cussac; Françoise Lejeune; Jean-Paul Nicolas; Francis Cogé; Jean-Pierre Galizzi; Jean A Boutin; Jean-Michel Rivet; Anne Dekeyne; Alain Gobert
Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states.
Synapse (New York, N.Y.) 2000;35(2):79-95.
2000: Cécile Pégurier; S Curtet; Jean-Paul Nicolas; Jean A Boutin; Philippe Delagrange; Pierre Renard; Michel Langlois
Synthesis of a small library of phenylalkylamide derivatives as melatoninergic ligands for human mt1 and MT2 receptors.
Bioorganic & medicinal chemistry 2000;8(1):163-71.
2000: Jean A Boutin; Chantal Lahaye; C Pegurier; Jean-Paul Nicolas; JL Fauchere; M Langlois; Pierre Renard; Philippe Delagrange; Emmanuel Canet
Screening of ligand binding on melatonin receptor using non-peptide combinatorial libraries.
Journal of receptor and signal transduction research 2000;20(1):105-18.
2000: Mark J Millan; Alain Gobert; Adrian Newman-Tancredi; Françoise Lejeune; Didier Cussac; Jean-Michel Rivet; Valérie Audinot; A Adhumeau; Mauricette Brocco; Jean-Paul Nicolas; Jean A Boutin; Nicole Despaux; Jean-Louis Peglion
S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: I. Receptorial, neurochemical, and electrophysiological profile.
The Journal of pharmacology and experimental therapeutics 2000;292(1):38-53.
1999: Francis Cogé; S P Guenin; A Renouard-Try; Herve RIQUE; C Ouvry; N Fabry; Philippe Beauverger; Jean-Paul Nicolas; Jean-Pierre Galizzi; Jean A Boutin; Emmanuel Canet
Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors.
The Biochemical journal 1999;343 Pt 1():231-9.
1999: P Paul; Chantal Lahaye; Philippe Delagrange; Jean-Paul Nicolas; Emmanuel Canet; Jean A Boutin
Characterization of 2-[125I]iodomelatonin binding sites in Syrian hamster peripheral organs.
The Journal of pharmacology and experimental therapeutics 1999;290(1):334-40.
1999: Michel Félétou; Jean-Paul Nicolas; M Rodriguez; Philippe Beauverger; Jean-Pierre Galizzi; Jean A Boutin; Jacques Duhault
NPY receptor subtype in the rabbit isolated ileum.
British journal of pharmacology 1999;127(3):795-801.
1999: A Acín; Marianne Rodriguez; Herve RIQUE; Emmanuel Canet; Jean A Boutin; Jean-Pierre Galizzi
Cloning and characterization of the 5' flanking region of the human uncoupling protein 3 (UCP3) gene.
Biochemical and biophysical research communications 1999;258(2):278-83.
1999: Jean A Boutin; Pierre-Hervé Lambert; Sophie Bertin; Jean-Paul Volland; Jean-Luc Fauchère
Physico-chemical and biological analysis of true combinatorial libraries.
Journal of chromatography. B, Biomedical sciences and applications 1999;725(1):17-37.
1999: Jean A Boutin; W Marande; L Petit; Armelle Loynel; C Desmet; Emmanuel Canet; Jean-Luc Fauchère
Investigation of S-farnesyl transferase substrate specificity with combinatorial tetrapeptide libraries.
Cellular signalling 1999;11(1):59-69.
1998: Michel Félétou; Marianne Rodriguez; Philippe Beauverger; M Germain; Jérôme Imbert; Sandra Dromaint; Christelle Macia; A Bourrienne; JM Henlin; Jean-Paul Nicolas; Jean A Boutin; Jean-Pierre Galizzi; Jean-Luc Fauchère; Emmanuel Canet; Jacques Duhault
NPY receptor subtypes involved in the contraction of the proximal colon of the rat.
Regulatory peptides 1998;75-76():221-9.
1998: Gilles Ferry; Jean A Boutin; Philippe Hennig; Annie Genton; C Desmet; Jean-Luc Fauchère; Ghanem Atassi; Gordon C Tucker
A zinc chelator inhibiting gelatinases exerts potent in vitro anti-invasive effects.
European journal of pharmacology 1998;351(2):225-33.
1998: Jean A Boutin; W Marande; M Goussard; Armelle Loynel; Emmanuel Canet; JL Fauchere
Chromatographic assay and peptide substrate characterization of partially purified farnesyl- and geranylgeranyltransferases from rat brain cytosol.
Archives of biochemistry and biophysics 1998;354(1):83-94.
1997: Jean-Luc Fauchère; JM Henlin; Jean A Boutin
Peptide and nonpeptide lead discovery using robotically synthesized soluble libraries.
Canadian journal of physiology and pharmacology 1997;75(6):683-9.
1997: Jean A Boutin; I Gesson; JM Henlin; Sophie Bertin; Pierre-Hervé Lambert; Jean-Paul Volland; Jean-Luc Fauchère
Limitations of the coupling of amino acid mixtures for the preparation of equimolar peptide libraries.
Molecular diversity 1997;3(1):43-60.
1997: Gilles Ferry; Jean A Boutin; Ghanem Atassi; Jean-Luc Fauchère; Gordon C Tucker
Selection of a histidine-containing inhibitor of gelatinases through deconvolution of combinatorial tetrapeptide libraries.
Molecular diversity 1997;2(3):135-46.
1996: Jean A Boutin; P Hennig; P H Lambert; Sophie Bertin; L Petit; J P Mahieu; B Serkiz; Jean-Paul Volland; Jean-Luc Fauchère
Combinatorial peptide libraries: robotic synthesis and analysis by nuclear magnetic resonance, mass spectrometry, tandem mass spectrometry, and high-performance capillary electrophoresis techniques.
Analytical biochemistry 1996;234(2):126-41.
1994: A P Ernould; Gilles Ferry; Jean-Marc Barret; A Genton; Jean A Boutin
Substrate phosphorylation capacities of the major tyrosine protein kinase from the human promyelocytic cell line, HL-60.
International journal of peptide and protein research 1994;43(5):496-504.
1993: Jean A Boutin; F Meunier; P H Lambert; P Hennig; D Bertin; B Serkiz; Jean-Paul Volland
In vivo and in vitro glucuronidation of the flavonoid diosmetin in rats.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1157-66.
1993: Jean-Marc Barret; A P Ernould; Gilles Ferry; A Genton; Jean A Boutin
Integrated system for the screening of the specificity of protein kinase inhibitors.
Biochemical pharmacology 1993;46(3):439-48.
1993: Jean A Boutin; Gilles Ferry; A P Ernould; P Maes; G Remond; M Vincent
Myristoyl-CoA:protein N-myristoyltransferase activity in cancer cells. Purification and characterization of a cytosolic isoform from the murine leukemia cell line L1210.
European journal of biochemistry / FEBS 1993;214(3):853-67.
1993: A P Ernould; Gilles Ferry; Jean-Marc Barret; A Genton; Jean A Boutin
Purification and characterization of the major tyrosine protein kinase from the human promyelocytic cell line, HL60.
European journal of biochemistry / FEBS 1993;214(2):503-14.
1993: Jean-Marc Barret; A P Ernould; M H Rouillon; Gilles Ferry; A Genton; Jean A Boutin
Studies of the potency of protein kinase inhibitors on ATPase activities.
Chemico-biological interactions 1993;86(1):17-27.
1992: Jean A Boutin; A P Ernould; Gilles Ferry; A Genton; A J Alpert
Use of hydrophilic interaction chromatography for the study of tyrosine protein kinase specificity.
Journal of chromatography 1992;583(2):137-43.
1992: Alain Pierré; V Pérez; Stéphane Léonce; Jean A Boutin; D Saint-Dizier; P Hautefaye; G Lavielle; Ghanem Atassi
Relationship between the cellular accumulation and the cytotoxicity of S12363, a new Vinca alkaloid derivative.
Cancer chemotherapy and pharmacology 1992;29(5):367-74.
1991: Jean A Boutin; J P Clarenc; Gilles Ferry; A P Ernould; G Remond; M Vincent; Ghanem Atassi
N-myristoyl-transferase activity in cancer cells. Solubilization, specificity and enzymatic inhibition of a N-myristoyl transferase from L1210 microsomes.
European journal of biochemistry / FEBS 1991;201(1):257-63.
1991: G Lavielle; P Hautefaye; C Schaeffer; Jean A Boutin; C A Cudennec; Alain Pierré
New alpha-amino phosphonic acid derivatives of vinblastine: chemistry and antitumor activity.
Journal of medicinal chemistry 1991;34(7):1998-2003.
1991: Laurence Kraus-Berthier; Gilles Ferry; V Combe-Perez; M Visalli; G Remond; M Vincent; Jean A Boutin
Approaches to some biochemical mechanisms of action of tuftsin and analogues.
Biochemical pharmacology 1991;41(10):1411-8.
1991: J P Tassin; Jean A Boutin; A P Ernould; Ghanem Atassi
[Farnesyltransferase as target for non-cytotoxic anti-cancer agents: first steps].
Comptes rendus des séances de la Société de biologie et de ses filiales 1991;185(5):306-11.
1990: Gilles Ferry; A P Ernould; A Genton; Jean A Boutin
Assay of tyrosine protein kinase activity from HL-60 by high-performance liquid chromatography for specificity studies.
Analytical biochemistry 1990;190(1):32-8.
1990: A P Ernould; Gilles Ferry; A Genton; C A Cudennec; Jean A Boutin
Use of the main tyrosine protein kinase activity purified from HL-60 in the search for a new class of anticancer compounds.
Anticancer research 1990;10(1):197-201.
1990: Alain Pierré; G Lavielle; P Hautefaye; G Seurre; S Leonce; D Saint-Dizier; Jean A Boutin; C A Cudennec
Pharmacological properties of a new alpha-aminophosphonic acid derivative of vinblastine.
Anticancer research 1990;10(1):139-44.
1989: Jean A Boutin; K Norbeck; P Moldeus; A Genton; M Paraire; J P Bizzari; G Lavielle; C A Cudennec
Effects of the new nitrosourea derivative, fotemustine, on the glutathione reductase activity in rat tissues in vivo and in isolated rat hepatocytes.
European journal of cancer & clinical oncology 1989;25(9):1311-6.
1989: Jean A Boutin; A P Ernould; A Genton; C A Cudennec
Partial purification and characterization of a new p36/40 tyrosine protein kinase from HL-60.
Biochemical and biophysical research communications 1989;160(3):1203-11.
1987: Jean A Boutin
Indirect evidences of UDP-glucuronosyltransferase heterogeneity: how can it help purification?
Drug metabolism reviews 1987;18(4):517-51.