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Harry van Steeg

Research Profile

Living Beings

Physiology

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TOP 3
Alexander Y Maslov; Wilber Quispe-Tintaya; Erwin Reiling; Bennett Van Houten; Harry van Steeg; Martijn E T Dollé; Shireen Ganapathi; Paul Hasty; Jan H J Hoeijmakers; Maaike Westerhof; Ryan R White; Jan Vijg
DNA damage in normally and prematurely aged mice.
P C E van Kesteren; Harry van Steeg; M J Zeilmaker; P E Zwart; B G H Bokkers; R W L Godschalk; J C S Kleinjans; T E Pronk; Mirjam M Schaap; Marcel H M van Herwijnen; Mirjam Luijten
Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons.
Joost P M Melis; Joke Robinson; Daniela C F Salvatori; Mirjam M Schaap; Ewoud N Speksnijder; Jan van Benthem; Raoul V Kuiper; Mirjam Luijten; Saskia Maas; Aart Verhoef; Harry van Steeg
Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice.

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All Publications

2013: Alexander Y Maslov; Wilber Quispe-Tintaya; Erwin Reiling; Bennett Van Houten; Harry van Steeg; Martijn E T Dollé; Shireen Ganapathi; Paul Hasty; Jan H J Hoeijmakers; Maaike Westerhof; Ryan R White; Jan Vijg
DNA damage in normally and prematurely aged mice.
Aging cell 2013;12(3):467-77.
2013: P C E van Kesteren; Harry van Steeg; M J Zeilmaker; P E Zwart; B G H Bokkers; R W L Godschalk; J C S Kleinjans; T E Pronk; Mirjam M Schaap; Marcel H M van Herwijnen; Mirjam Luijten
Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons.
Archives of toxicology 2013;87(3):505-15.
2013: Joost P M Melis; Joke Robinson; Daniela C F Salvatori; Mirjam M Schaap; Ewoud N Speksnijder; Jan van Benthem; Raoul V Kuiper; Mirjam Luijten; Saskia Maas; Aart Verhoef; Harry van Steeg
Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice.
Toxicology and applied pharmacology 2013;266(2):289-97.
2012: Mirjam M Schaap; Bob van de Water; Harry van Steeg; Paul F K Wackers; Edwin P Zwart; Timo M Breit; Ilse Huijskens; Martijs J Jonker; Mirjam Luijten
Dissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.
Archives of toxicology 2012;86(11):1717-27.
2011: Joost P M Melis; Leon H F Mullenders; Mirjam Luijten; Harry van Steeg
The role of XPC: implications in cancer and oxidative DNA damage.
Mutation research 2011;728(3):107-17.
2011: Petra C E van Kesteren; Harry van Steeg; P Edwin Zwart; W H Ralph Gottschalk; Jos C S Kleinjans; Jeroen L A Pennings; Joost H M van Delft; Mirjam Luijten
Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene.
Toxicological sciences : an official journal of the Society of Toxicology 2011;123(1):123-32.
2011: Sander M Botter; Martijn E T Dollé; Jan H J Hoeijmakers; Gerjo J V M van Osch; Harry van Steeg; Harrie Weinans; Michel Zar; Johannes P T M van Leeuwen
Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy.
Age (Dordrecht, Netherlands) 2011;33(3):247-60.
2011: Xiaolian Yuan; Jos G Bessems; Timo M Breit; Jillian de Wilde; Betty C Hakkert; Martijs J Jonker; Raoul V Kuiper; Jan van Benthem; Harry van Steeg; Aart Verhoef; Floyd R A Wittink; Mirjam Luijten
Finding maximal transcriptome differences between reprotoxic and non-reprotoxic phthalate responses in rat testis.
Journal of applied toxicology : JAT 2011;31(5):421-30.
2011: J P M Melis; E M Hoogervorst; C T M van Oostrom; E Zwart; T M Breit; Jeroen L A Pennings; Annemieke de Vries; Harry van Steeg
Genotoxic exposure: novel cause of selection for a functional ΔN-p53 isoform.
Oncogene 2011;30(15):1764-72.
2011: Martijn E T Dollé; Paul Hasty; Jan H J Hoeijmakers; Raoul V Kuiper; Laura J Niedernhofer; Joke Robinson; Marianne Roodbergen; Ingrid van der Pluijm; Rudolf B Beems; Liset de la Fonteyne; Sisca de Vlugt; Piet de With; Jan Vijg; Susan W P Wijnhoven; Harry van Steeg
Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice.
Pathobiology of aging & age related diseases 2011;1():.
2011: Nicole Verhofstad; Conny Th M van Oostrom; Edwin Zwart; Lou M Maas; Jan van Benthem; Frederik J Van Schooten; Harry van Steeg; Roger W L Godschalk
Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(1):218-23.
2010: Feng Zhu; Martijn E T Dollé; Thomas R Berton; Raoul V Kuiper; Carrie Capps; Alexsandra Espejo; Mark J McArthur; Mark T Bedford; Harry van Steeg; Annemieke de Vries; David G Johnson
Mouse models for the p53 R72P polymorphism mimic human phenotypes.
Cancer research 2010;70(14):5851-9.
2010: Nicole Verhofstad; Conny Th M van Oostrom; Jan van Benthem; Frederik J Van Schooten; Harry van Steeg; Roger Godschalk
DNA adduct kinetics in reproductive tissues of DNA repair proficient and deficient male mice after oral exposure to benzo(a)pyrene.
Environmental and molecular mutagenesis 2010;51(2):123-9.
2010: York Kamenisch; Maria Fousteri; Jennifer Knoch; Anna-Katharina von Thaler; Birgit Fehrenbacher; Hiroki Kato; Thomas Becker; Martijn E T Dollé; Raoul Kuiper; Marc Majora; Martin Schaller; Gijsbertus T J van der Horst; Harry van Steeg; Martin Röcken; Doron Rapaport; Jean Krutmann; Leon H Mullenders; Mark Berneburg
Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging.
The Journal of experimental medicine 2010;207(2):379-90.
2010: Santosh K Katiyar; Mudit Vaid; Harry van Steeg; Syed M Meeran
Green tea polyphenols prevent UV-induced immunosuppression by rapid repair of DNA damage and enhancement of nucleotide excision repair genes.
Cancer prevention research (Philadelphia, Pa.) 2010;3(2):179-89.
2010: Nicole Verhofstad; Jeroen L A Pennings; Conny Th M van Oostrom; Jan van Benthem; Frederik J Van Schooten; Harry van Steeg; Roger Godschalk
Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice.
BMC genomics 2010;11():333.
2010: Anuska G Mahabir; Mirjam M Schaap; Jeroen L A Pennings; Jan van Benthem; Coenraad F M Hendriksen; Harry van Steeg
Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells.
BMC genomics 2010;11():24.
2009: Edoardo Zattra; Christina Coleman; Simin Arad; Elizabeth Helms; Danielle Levine; Evelyn Bord; Alexandra Guillaume; Mohamad El-Hajahmad; Edwin Zwart; Harry van Steeg; Salvador Gonzalez; Raj Kishore; David Goukassian
Polypodium leucotomos extract decreases UV-induced Cox-2 expression and inflammation, enhances DNA repair, and decreases mutagenesis in hairless mice.
The American journal of pathology 2009;175(5):1952-61.
2009: El Mustapha Bahassi; Susan B Robbins; Moying Yin; Gregory P Boivin; Raoul Kuiper; Harry van Steeg; Peter J Stambrook
Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(40):17111-6.
2009: Martijs J Jonker; Oskar Bruning; Maarten van Iterson; Mirjam M Schaap; Tessa V van der Hoeven; Harry Vrieling; Rudolf B Beems; Annemieke de Vries; Harry van Steeg; Timo M Breit; Mirjam Luijten
Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models.
Carcinogenesis 2009;30(10):1805-12.
2009: Lya G Hernández; Harry van Steeg; Mirjam Luijten; Jan van Benthem
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
Mutation research 2009;682(2-3):94-109.
2009: Anuska G Mahabir; Edwin Zwart; Mirjam Schaap; Jan van Benthem; Annemieke de Vries; Lya G Hernandez; Coenraad F M Hendriksen; Harry van Steeg
lacZ mouse embryonic fibroblasts detect both clastogens and mutagens.
Mutation research 2009;666(1-2):50-6.
2009: george garinis; Lieneke M Uittenboogaard; Heike Stachelscheid; Maria Fousteri; Wilfred van Ijcken; Timo M Breit; Harry van Steeg; Leon H F Mullenders; Gijsbertus T J van der Horst; Jens C Brüning; Carien M Niessen; Jan H J Hoeijmakers; Björn Schumacher
Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.
Nature cell biology 2009;11(5):604-15.
2009: Petra C E van Kesteren; Rudolf B Beems; Mirjam Luijten; Joke Robinson; Annemieke de Vries; Harry van Steeg
DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance?
Carcinogenesis 2009;30(3):538-43.
2009: Jaan-Olle Andressoo; Geert Weeda; Jan de Wit; James R Mitchell; Rudolf B Beems; Harry van Steeg; Gijsbertus T J van der Horst; Jan H Hoeijmakers
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Molecular and cellular biology 2009;29(5):1276-90.
2008: Anuska G Mahabir; Mirjam Schaap; Peter Theunissen; Jan van Benthem; Jeroen Essers; Annemieke de Vries; Coenraad F M Hendriksen; Harry van Steeg
DNA-repair-deficient Rad54/Rad54B mice are more sensitive to clastogens than wild-type mice.
Toxicology letters 2008;183(1-3):112-7.
2008: Nicole Verhofstad; Joost O Linschooten; Jan van Benthem; Yuri E Dubrova; Harry van Steeg; Frederik J Van Schooten; Roger Godschalk
New methods for assessing male germ line mutations in humans and genetic risks in their offspring.
Mutagenesis 2008;23(4):241-7.
2008: Anuska G Mahabir; Jan van Benthem; Hanneke Korsten; Anthony Lynch; Lorna Bailey; Annemieke de Vries; Coenradus F M Hendriksen; Harry van Steeg
Detecting genotoxic effects of potential clastogens: an in vivo study using the transgenic lacZ plasmid and the MutaMouse model.
Mutation research 2008;652(2):151-7.
2008: Anthony Lynch; Anuska G Mahabir; Andrea Bradford; Kate Brockhurst; Jan van Benthem; Harry van Steeg; Robert W Rees
Is MutaMouse insensitive to clastogens?
Mutation research 2008;652(2):145-50.
2008: Albert A van Zeeland; Anton J de Groot; Georges R Mohn; Harry van Steeg; Conny Th M van Oostrom; Anne-Marie van Duijn-Goedhart; Leon F H Mullenders; Jacob G Jansen
Reduced methylation-induced mutagenesis in rat splenocytes in vivo by sub-chronic low dose exposure to N-metyl-N-nitrosourea.
Mutation research 2008;640(1-2):131-8.
2008: Joost P M Melis; Susan W P Wijnhoven; Rudolf B Beems; Marianne Roodbergen; Jolanda van den Berg; Hojin Moon; Errol Friedberg; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Jan Vijg; Harry van Steeg
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.
Cancer research 2008;68(5):1347-53.
2008: Flemming R Cassee; Claire de Burbure; Bisoen Rambali; Wim Vleeming; A van de Kuil; Harry van Steeg; Paul H B Fokkens; J G C van Amsterdam; J A M A Dormans; Antoon Opperhuizen
Subchronic inhalation of mixtures of cigarette smoke constituents in Xpa-/-p53+/- knock-out mice: a comparison of intermittent with semi-continuous exposure to acetaldehyde, formaldehyde, and acrolein.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(2):527-36.
2008: Björn Schumacher; Ingrid van der Pluijm; Michael J Moorhouse; Theodore Kosteas; Andria Rasile Robinson; Yousin Suh; Timo M Breit; Harry van Steeg; Laura J Niedernhofer; Wilfred van Ijcken; Andrzej Bartke; Stephen R Spindler; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; George A Garinis
Delayed and accelerated aging share common longevity assurance mechanisms.
PLoS genetics 2008;4(8):e1000161.
2008: Jung Yoon Park; Mi-Ook Cho; Shanique Leonard; Brent Calder; I Saira Mian; Woo Ho Kim; Susan Wijnhoven; Harry van Steeg; James Mitchell; Gijsbertus T J van der Horst; Jan Hoeijmakers; Pinchas Cohen; Jan Vijg; Yousin Suh
Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice.
PloS one 2008;3(6):e2346.
2008: Kirsten A Baken; Jeroen L A Pennings; Martijs J Jonker; Mirjam M Schaap; Annemieke de Vries; Harry van Steeg; Timo M Breit; Henk Van Loveren
Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening.
Toxicology and applied pharmacology 2008;226(1):46-59.
2007: Wendy Bruins; Martijs J Jonker; Oskar Bruning; Jeroen L A Pennings; Mirjam M Schaap; Esther M Hoogervorst; Harry van Steeg; Timo M Breit; Annemieke de Vries
Delayed expression of apoptotic and cell-cycle control genes in carcinogen-exposed bladders of mice lacking p53.S389 phosphorylation.
Carcinogenesis 2007;28(8):1814-23.
2007: Susan W P Wijnhoven; Ewoud N Speksnijder; Xiaoling Liu; Edwin Zwart; Conny Th M vanOostrom; Rudolf B Beems; Esther M Hoogervorst; Mirjam M Schaap; Laura D Attardi; Tyler Jacks; Harry van Steeg; Jos Jonkers; Annemieke de Vries
Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage.
Cancer research 2007;67(10):4648-56.
2007: Ingeborg M Kooter; Jeroen L A Pennings; Paul H B Fokkens; Daan L A C Leseman; john boere; Miriam E Gerlofs-Nijland; Flemming R Cassee; Johanna A C Schalk; Tom J H Orzechowski; Mirjam M Schaap; Timo M Breit; J A M A Dormans; Conny Th M van Oostrom; Annemieke de Vries; Harry van Steeg
Ozone induces clear cellular and molecular responses in the mouse lung independently of the transcription-coupled repair status.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;102(3):1185-92.
2007: Theo G M F Gorgels; Ingrid van der Pluijm; Renata M C Brandt; george garinis; Harry van Steeg; Gerard van den Aardweg; Gerard H Jansen; Jan M Ruijter; Arthur A B Bergen; Dirk van Norren; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome.
Molecular and cellular biology 2007;27(4):1433-41.
2007: Susan W P Wijnhoven; Esther M Hoogervorst; Harm de Waard; Gijsbertus T J van der Horst; Harry van Steeg
Tissue specific mutagenic and carcinogenic responses in NER defective mouse models.
Mutation research 2007;614(1-2):77-94.
2007: R Brent Calder; Rudolf B Beems; Harry van Steeg; I Saira Mian; Paul H M Lohman; Jan Vijg
MPHASYS: a mouse phenotype analysis system.
BMC bioinformatics 2007;8():183.
2007: Ingrid van der Pluijm; george garinis; Renata M C Brandt; Theo G M F Gorgels; Susan W P Wijnhoven; Karin E M Diderich; Jan de Wit; James R Mitchell; Conny Th M van Oostrom; Rudolf B Beems; Laura J Niedernhofer; Susana Velasco; Errol C Friedberg; Kiyoji Tanaka; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.
PLoS biology 2007;5(1):e2.
2007: Aart A van Apeldoorn; Jan de Boer; Harry van Steeg; Jan H J Hoeijmakers; Cees Otto; Clemens A van Blitterswijk
Physicochemical composition of osteoporotic bone in the trichothiodystrophy premature aging mouse determined by confocal Raman microscopy.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(1):34-40.
2007: Marieke van de Ven; Jaan-Olle Andressoo; Valerie B Holcomb; Edward Hasty; Yousin Suh; Harry van Steeg; george garinis; Jan H J Hoeijmakers; James R Mitchell
Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.
Mechanisms of ageing and development 2007;128(1):58-63.
2006: Kirsten A Baken; Jeroen L A Pennings; Annemieke de Vries; Timo M Breit; Harry van Steeg; Henk Van Loveren
Gene expression profiling of Bis(tri-n-butyltin)oxide (TBTO)-induced immunotoxicity in mice and rats.
Journal of immunotoxicology 2006;3(4):227-44.
2006: Jaan-Olle Andressoo; James R Mitchell; Jan de Wit; Deborah Hoogstraten; Marcel Volker; Wendy Toussaint; Ewoud Speksnijder; Rudolf B Beems; Harry van Steeg; Judith Jans; Chris I De Zeeuw; Nicolaas G J Jaspers; Anja Raams; Alan Lehmann; Wim Vermeulen; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.
Cancer cell 2006;10(2):121-32.
2006: Martijn E T Dollé; Rita A Busuttil; Ana Maria Garcia; Susan W P Wijnhoven; Ellen van Drunen; Laura J Niedernhofer; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Harry van Steeg; Jan Vijg
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice.
Mutation research 2006;596(1-2):22-35.
2006: Mirjam Luijten; Ewoud N Speksnijder; Niels van Alphen; Anja Westerman; Siem H Heisterkamp; Jan van Benthem; Coen F van Kreijl; Rudolf B Beems; Harry van Steeg
Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice.
Mutation research 2006;596(1-2):143-50.
2006: Agatha Schwarz; Akira Maeda; Sonja Ständer; Harry van Steeg; Thomas Schwarz
IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2896-901.
2006: Joanna Wesoly; Sheba Agarwal; Stefan Sigurdsson; Wendy Bussen; Stephen Van Komen; Jian Qin; Harry van Steeg; Jan van Benthem; Evelyne Wassenaar; Willy M Baarends; Mehrnaz Ghazvini; Agnieszka A Tafel; Helen Heath; Niels Galjart; Jeroen Essers; J Anton Grootegoed; Norman Arnheim; Olga Bezzubova; Jean-Marie Buerstedde; Patrick Sung; Roland Kanaar
Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis.
Molecular and cellular biology 2006;26(3):976-89.
2005: Hester van der Woude; Gerrit M Alink; Bart E J van Rossum; Kristina Walle; Harry van Steeg; Thomas Walle; Ivonne M C M Rietjens
Formation of transient covalent protein and DNA adducts by quercetin in cells with and without oxidative enzyme activity.
Chemical research in toxicology 2005;18(12):1907-16.
2005: Susan W P Wijnhoven; Rudolf B Beems; Marianne Roodbergen; Jolanda van den Berg; Paul H M Lohman; Karin Diderich; Gijsbertus T J van der Horst; Jan Vijg; Jan H J Hoeijmakers; Harry van Steeg
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction.
DNA repair 2005;4(11):1314-24.
2005: Femke A T de Vries; José B M Zonneveld; Annemarie van Duijn-Goedhart; Marianne Roodbergen; J J W A Boei; Paul P W van Buul; Jeroen Essers; Harry van Steeg; Albert A van Zeeland; Jan van Benthem; Albert Pastink
Inactivation of RAD52 aggravates RAD54 defects in mice but not in Schizosaccharomyces pombe.
DNA repair 2005;4(10):1121-8.
2005: Susan W P Wijnhoven; Edwin Zwart; Ewoud N Speksnijder; Rudolf B Beems; Kenneth P Olive; David A Tuveson; Jos Jonkers; Mirjam M Schaap; Jolanda van den Berg; Tyler Jacks; Harry van Steeg; Annemieke de Vries
Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development.
Cancer research 2005;65(18):8166-73.
2005: Awni Sarrif; Joost H M van Delft; Frederik J Van Schooten; Timothy W Gant; Barry M Elliott; Bennard van Ravenzwaay; Harry van Steeg; Hendrik Vrijhof
Toxicogenomics in genetic toxicology and hazard determination: introduction and overview.
Mutation research 2005;575(1-2):1-3.
2005: Esther M Hoogervorst; Harry van Steeg; Annemieke de Vries
Nucleotide excision repair- and p53-deficient mouse models in cancer research.
Mutation research 2005;574(1-2):3-21.
2005: Femke A van den Berg; Kirsten A Baken; Jolanda P Vermeulen; Eric R Gremmer; Harry van Steeg; Henk Van Loveren
Use of the local lymph node assay in assessment of immune function.
Toxicology 2005;211(1-2):107-14.
2005: Esther M Hoogervorst; Wendy Bruins; Edwin Zwart; Conny Th M van Oostrom; Gerard van den Aardweg; Rudolf B Beems; Jolanda van den Berg; Tyler Jacks; Harry van Steeg; Annemieke de Vries
Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas.
Cancer research 2005;65(9):3610-6.
2005: Lisya Gerez; Annett de Haan; Elly M Hol; David F Fischer; Fijs W B van Leeuwen; Harry van Steeg; Rob Benne
Molecular misreading: the frequency of dinucleotide deletions in neuronal mRNAs for beta-amyloid precursor protein and ubiquitin B.
Neurobiology of aging 2005;26(2):145-55.
2005: Judith Jans; Wouter Schul; Yurda-Gul Sert; Yvonne Rijksen; Heggert Rebel; Andre P M Eker; Satoshi Nakajima; Harry van Steeg; Frank R de Gruijl; Akira Yasui; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Powerful skin cancer protection by a CPD-photolyase transgene.
Current biology : CB 2005;15(2):105-15.
2005: Agatha Schwarz; Akira Maeda; Kerstin Kernebeck; Harry van Steeg; Stefan Beissert; Thomas Schwarz
Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair.
The Journal of experimental medicine 2005;201(2):173-9.
2005: Esther M Hoogervorst; Conny Th M van Oostrom; Rudolf B Beems; Jan van Benthem; Jolanda van den Berg; Coen F van Kreijl; Joseph G Vos; Annemieke de Vries; Harry van Steeg
2-AAF-induced tumor development in nucleotide excision repair-deficient mice is associated with a defect in global genome repair but not with transcription coupled repair.
DNA repair 2005;4(1):3-9.
2004: Wendy Bruins; Edwin Zwart; Laura D Attardi; Tomoo Iwakuma; Esther M Hoogervorst; Rudolf B Beems; Barbara Miranda; Conny Th M van Oostrom; Jolanda van den Berg; Gerard van den Aardweg; Guillermina Lozano; Harry van Steeg; Tyler Jacks; Annemieke de Vries
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.
Molecular and cellular biology 2004;24(20):8884-94.
2004: Harm de Waard; Jan de Wit; Jaan-Olle Andressoo; Conny Th M van Oostrom; Bente Riis; Allan Weimann; Henrik E Poulsen; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage.
Molecular and cellular biology 2004;24(18):7941-8.
2004: Esther M Hoogervorst; Conny Th M van Oostrom; Rudolf B Beems; Jan van Benthem; Siska Gielis; Jolanda P Vermeulen; Piet W Wester; Joseph G Vos; Annemieke de Vries; Harry van Steeg
p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.
Cancer research 2004;64(15):5118-26.
2004: David Goukassian; Elizabeth Helms; Harry van Steeg; Conny Th M van Oostrom; Jag Bhawan; Barbara A Gilchrest
Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(11):3933-8.
2003: Susan W P Wijnhoven; Harry van Steeg
Transgenic and knockout mice for DNA repair functions in carcinogenesis and mutagenesis.
Toxicology 2003;193(1-2):171-87.
2003: Wendy Kölgen; Harry van Steeg; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Willem A van Vloten; Frank R de Gruijl; Johan Garssen
Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression.
The Journal of investigative dermatology 2003;121(4):751-6.
2003: Esther M Hoogervorst; Annemieke de Vries; Rudolf B Beems; Conny Th M van Oostrom; Piet W Wester; Joseph G Vos; Wendy Bruins; Marianne Roodbergen; Flemming R Cassee; Jan Vijg; Frederik J Van Schooten; Harry van Steeg
Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice.
Carcinogenesis 2003;24(3):613-9.
2003: Edward Hasty; Judith Campisi; Jan H J Hoeijmakers; Harry van Steeg; Jan Vijg
Aging and genome maintenance: lessons from the mouse?
Science (New York, N.Y.) 2003;299(5611):1355-9.
2003: Harm de Waard; Jan de Wit; Theo G M F Gorgels; Gerard van den Aardweg; Jaan-Olle Andressoo; Marcel Vermeij; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice.
DNA repair 2003;2(1):13-25.
2002: Jan de Boer; Jaan-Olle Andressoo; Jan de Wit; Jan G M Huijmans; Rudolf B Beems; Harry van Steeg; Geert Weeda; Gijsbertus T J van der Horst; Wibeke J van Leeuwen; Axel P N Themmen; Morteza Meradji; Jan H J Hoeijmakers
Premature aging in mice deficient in DNA repair and transcription.
Science (New York, N.Y.) 2002;296(5571):1276-9.
2002: Heggert Rebel; Harry van Steeg; Rudolf B Beems; Ron Schouten; Frank R de Gruijl; Carrol Terleth
Suppression of UV carcinogenesis by difluoromethylornithine in nucleotide excision repair-deficient Xpa knockout mice.
Cancer research 2002;62(5):1338-42.
2002: Andrew Tutt; Conny Th M van Oostrom; Gillian M Ross; Harry van Steeg; Alan Ashworth
Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.
EMBO reports 2002;3(3):255-60.
2002: Heidi Giese; Wendy K Snyder; Conny Th M van Oostrom; Harry van Steeg; Martijn E T Dollé; Jan Vijg
Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice.
Mutation research 2002;514(1-2):153-63.
2002: Agatha Schwarz; Sonja Ständer; Mark Berneburg; Markus Böhm; Dagmar Kulms; Harry van Steeg; Karin Grosse-Heitmeyer; Jean Krutmann; Thomas Schwarz
Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair.
Nature cell biology 2002;4(1):26-31.
2001: Douglas E Brash; Norbert Wikonkál; Eva Remenyik; Gijsbertus T J van der Horst; E C Friedberg; D L Cheo; Harry van Steeg; Anja Westerman; Henk J van Kranen
The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes.
The Journal of investigative dermatology 2001;117(5):1234-40.
2001: A Boonstra; Adri van Oudenaren; Miranda Baert; Harry van Steeg; Pieter J M Leenen; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Huub F J Savelkoul; Johan Garssen
Differential ultraviolet-B-induced immunomodulation in XPA, XPC, and CSB DNA repair-deficient mice.
The Journal of investigative dermatology 2001;117(1):141-6.
2001: J C Klein; Rudolf B Beems; P E Zwart; M Hamzink; G Zomer; Harry van Steeg; Coen F van Kreijl
Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice.
Carcinogenesis 2001;22(4):619-26.
2001: Harry van Steeg
The role of nucleotide excision repair and loss of p53 in mutagenesis and carcinogenesis.
Toxicology letters 2001;120(1-3):209-19.
2001: Heggert Rebel; L O Mosnier; Rob J W Berg; A Westerman-de Vries; Harry van Steeg; Henk J van Kranen; Frank R de Gruijl
Early p53-positive foci as indicators of tumor risk in ultraviolet-exposed hairless mice: kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosity.
Cancer research 2001;61(3):977-83.
2001: Coen F van Kreijl; P A McAnulty; Rudolf B Beems; A Vynckier; Harry van Steeg; R Fransson-Steen; C L Alden; Roy FORSTER; J W van der Laan; J Vandenberghe
Xpa and Xpa/p53+/- knockout mice: overview of available data.
Toxicologic pathology 2001;29 Suppl():117-27.
2001: Harry van Steeg; Annemieke de Vries; Jan van Benthem; Rudolf B Beems; Coen F van Kreijl
DNA repair-deficient Xpa and Xpa/p53+/- knock-out mice: nature of the models.
Toxicologic pathology 2001;29 Suppl():109-16.
2000: Susan W P Wijnhoven; Hanneke Kool; Conny Th M van Oostrom; Rudolf B Beems; Leon H F Mullenders; Albert A van Zeeland; Gijsbertus T J van der Horst; Harry Vrieling; Harry van Steeg
The relationship between benzo[a]pyrene-induced mutagenesis and carcinogenesis in repair-deficient Cockayne syndrome group B mice.
Cancer research 2000;60(20):5681-7.
2000: Susan W P Wijnhoven; Hanneke Kool; Leon H F Mullenders; Albert A van Zeeland; Errol C Friedberg; Gijsbertus T J van der Horst; Harry van Steeg; Harry Vrieling
Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair.
Oncogene 2000;19(43):5034-7.
2000: Marijke van Oosten; Heggert Rebel; Errol C Friedberg; Harry van Steeg; Gijsbertus T J van der Horst; Henk J van Kranen; Anja Westerman; Albert A van Zeeland; Leon H F Mullenders; Frank R de Gruijl
Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11268-73.
2000: Mies L G Dronkert; Jan de Wit; M Boeve; M L Vasconcelos; Harry van Steeg; T L Raoul Tan; Jan H J Hoeijmakers; Roland Kanaar
Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C.
Molecular and cellular biology 2000;20(13):4553-61.
2000: Johan Garssen; Harry van Steeg; Frank R de Gruijl; Jan de Boer; Gijsbertus T J van der Horst; Henk J van Kranen; Henk Van Loveren; M Van Dijk; A Fluitman; Geert Weeda; Jan H J Hoeijmakers
Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6199-205.
2000: Harry van Steeg; L H Mullenders; Jan Vijg
Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice.
Mutation research 2000;450(1-2):167-80.
2000: Jeroen Essers; Harry van Steeg; Jan de Wit; SM Swagemakers; Marcel Vermeij; Jan H J Hoeijmakers; Roland Kanaar
Homologous and non-homologous recombination differentially affect DNA damage repair in mice.
The EMBO journal 2000;19(7):1703-10.
1999: Jan de Boer; Harry van Steeg; Rob J W Berg; Johan Garssen; Jan de Wit; C T van Oostrum; Rudolf B Beems; Gijsbertus T J van der Horst; Coen F van Kreijl; Frank R de Gruijl; Dirk Bootsma; Jan H J Hoeijmakers; Geert Weeda
Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.
Cancer research 1999;59(14):3489-94.
1999: SA Bol; Harry van Steeg; Conny Th M van Oostrom; Ad D Tates; Harry Vrieling; Anton J de Groot; Leon H F Mullenders; Albert A van Zeeland; Jacob G Jansen
Nucleotide excision repair modulates the cytotoxic and mutagenic effects of N-n-butyl-N-nitrosourea in cultured mammalian cells as well as in mouse splenocytes in vivo.
Mutagenesis 1999;14(3):317-22.
1999: Heidi Giese; Martijn E T Dollé; A Hezel; Harry van Steeg; Jan Vijg
Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA.
Oncogene 1999;18(5):1257-60.
1999: Harry van Steeg; K H Kraemer
Xeroderma pigmentosum and the role of UV-induced DNA damage in skin cancer.
Molecular medicine today 1999;5(2):86-94.
1999: Conny Th M van Oostrom; M Boeve; Jolanda van den Berg; Annemieke de Vries; Martijn E T Dollé; Rudolf B Beems; Coen F van Kreijl; Jan Vijg; Harry van Steeg
Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice.
Environmental and molecular mutagenesis 1999;34(2-3):124-30.
1998: Coen F van Kreijl; Harry van Steeg
Transgenic mouse models for the identification of human carcinogens: a European perspective.
Toxicologic pathology 1998;26(6):757-8.
1998: Harry van Steeg; H Klein; Rudolf B Beems; Coen F van Kreijl
Use of DNA repair-deficient XPA transgenic mice in short-term carcinogenicity testing.
Toxicologic pathology 1998;26(6):742-9.
1998: Annemieke de Vries; Theo G M F Gorgels; Rob J W Berg; Gerard H Jansen; Harry van Steeg
Ultraviolet-B induced hyperplasia and squamous cell carcinomas in the cornea of XPA-deficient mice.
Experimental eye research 1998;67(1):53-9.
1998: SA Bol; Harry van Steeg; Jacob G Jansen; Conny Th M van Oostrom; Annemieke de Vries; Anton J de Groot; Ad D Tates; Harry Vrieling; Albert A van Zeeland; Leon H F Mullenders
Elevated frequencies of benzo(a)pyrene-induced Hprt mutations in internal tissue of XPA-deficient mice.
Cancer research 1998;58(13):2850-6.
1998: Jan de Boer; Jan de Wit; Harry van Steeg; Rob J W Berg; Hans Morreau; P Visser; Alan Lehmann; M Duran; Jan H J Hoeijmakers; Geert Weeda
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy.
Molecular cell 1998;1(7):981-90.
1998: Annemieke de Vries; Rob J W Berg; Susan W P Wijnhoven; Anja Westerman; Piet W Wester; Coen F van Kreijl; PJ Capel; Frank R de Gruijl; Henk J van Kranen; Harry van Steeg
XPA-deficiency in hairless mice causes a shift in skin tumor types and mutational target genes after exposure to low doses of U.V.B.
Oncogene 1998;16(17):2205-12.
1998: A F Frijhoff; C A Krul; A de Vries; M C Kelders; Geert Weeda; Harry van Steeg; RA Baan
Influence of nucleotide excision repair on N-hydroxy-2-acetylaminofluorene-induced mutagenesis studied in lambda lacZ-transgenic mice.
Environmental and molecular mutagenesis 1998;31(1):41-7.
1997: Annemieke de Vries; Martijn E T Dollé; J L Broekhof; J J Muller; ED Kroese; Coen F van Kreijl; PJ Capel; Jan Vijg; Harry van Steeg
Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development.
Carcinogenesis 1997;18(12):2327-32.
1997: Carrol Terleth; Theo van Laar; Ron Schouten; Harry van Steeg; H Hodemaekers; T Wormhoudt; Paulien Cornelissen-Steijger; Peter J Abrahams; Alex J van der Eb
A lack of radiation-induced ornithine decarboxylase activity prevents enhanced reactivation of herpes simplex virus and is linked to non-cancer proneness in xeroderma pigmentosum patients.
Cancer research 1997;57(19):4384-92.
1997: Geert Weeda; I Donker; Jan de Wit; Hans Morreau; R Janssens; C J Vissers; Alex L Nigg; Harry van Steeg; Dirk Bootsma; Jan H J Hoeijmakers
Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence.
Current biology : CB 1997;7(6):427-39.
1997: Gijsbertus T J van der Horst; Harry van Steeg; Rob J W Berg; Alain van Gool; Jan de Wit; Geert Weeda; Hans Morreau; Rudolf B Beems; Coen F van Kreijl; Frank R de Gruijl; Dirk Bootsma; Jan H J Hoeijmakers
Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.
Cell 1997;89(3):425-35.
1997: Annemieke de Vries; Conny Th M van Oostrom; PM Dortant; Rudolf B Beems; Coen F van Kreijl; PJ Capel; Harry van Steeg
Spontaneous liver tumors and benzo[a]pyrene-induced lymphomas in XPA-deficient mice.
Molecular carcinogenesis 1997;19(1):46-53.
1997: ED Kroese; PM Dortant; Harry van Steeg; Conny Th M van Oostrom; CW van der Houven van Oordt; Henk J van Kranen; Annemieke de Vries; Piet W Wester; Coen F van Kreijl
Use of E mu-PIM-1 transgenic mice short-term in vivo carcinogenicity testing: lymphoma induction by benzo[a]pyrene, but not by TPA.
Carcinogenesis 1997;18(5):975-80.
1997: Rob J W Berg; Annemieke de Vries; Harry van Steeg; Frank R de Gruijl
Relative susceptibilities of XPA knockout mice and their heterozygous and wild-type littermates to UVB-induced skin cancer.
Cancer research 1997;57(4):581-4.
1996: Annemieke de Vries; Harry van Steeg
Xpa knockout mice.
Seminars in cancer biology 1996;7(5):229-40.
1995: Annemieke de Vries; Conny Th M van Oostrom; Frans M A Hofhuis; PM Dortant; Rob J W Berg; Frank R de Gruijl; Piet W Wester; Coen F van Kreijl; PJ Capel; Harry van Steeg; S J Verbeek
Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.
Nature 1995;377(6545):169-73.
1994: Henk J van Kranen; Harry van Steeg; L Schoren; P Faessen; Annemieke de Vries; P W van Iersel; Coen F van Kreijl
The rat N-ras gene; interference of pseudogenes with the detection of activating point mutations.
Carcinogenesis 1994;15(2):307-11.
1994: Conny Th M van Oostrom; Annemieke de Vries; Sjef Verbeek; Coen F van Kreijl; Harry van Steeg
Cloning and characterization of the mouse XPAC gene.
Nucleic acids research 1994;22(1):11-4.
1993: G J Arts; H van der Spek; Dave Speijer; J van den Burg; Harry van Steeg; P Sloof; Rob Benne
Implications of novel guide RNA features for the mechanism of RNA editing in Crithidia fasciculata.
The EMBO journal 1993;12(4):1523-32.
1992: P Sloof; A de Haan; W Eier; M van Iersel; E Boel; Harry van Steeg; Rob Benne
The nucleotide sequence of the variable region in Trypanosoma brucei completes the sequence analysis of the maxicircle component of mitochondrial kinetoplast DNA.
Molecular and biochemical parasitology 1992;56(2):289-99.
1992: G Berben-Bloemheuvel; M A Kasperaitis; H van Heugten; Adri A M Thomas; Harry van Steeg; Harry O Voorma
Interaction of initiation factors with the cap structure of chimaeric mRNA containing the 5'-untranslated regions of Semliki Forest virus RNA is related to translational efficiency.
European journal of biochemistry / FEBS 1992;208(3):581-7.
1992: G Nguyen-Ba; S Robert; C Lasne; L Ventura; I Chouroulinkov; Coen F van Kreijl; Harry van Steeg; R Truhaut
[Specific induction by phorbol ester of the gene transcription and of the activity of ornithine decarboxylase in two control and transformed epithelial cell lines. Modulator effect of anti-inflammatory agents].
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1992;314(11):485-92.
1991: Harry van Steeg; Conny Th M van Oostrom; H M Hodemaekers; L Peters; Adri A M Thomas
The translation in vitro of rat ornithine decarboxylase mRNA is blocked by its 5' untranslated region in a polyamine-independent way.
The Biochemical journal 1991;274 ( Pt 2)():521-6.
1990: Harry van Steeg; Conny Th M van Oostrom; H M Hodemaekers; C F van Kreyl
Cloning and functional analysis of the rat ornithine decarboxylase-encoding gene.
Gene 1990;93(2):249-56.
1990: H Van der Spek; Dave Speijer; G J Arts; J Van den Burg; Harry van Steeg; P Sloof; Rob Benne
RNA editing in transcripts of the mitochondrial genes of the insect trypanosome Crithidia fasciculata.
The EMBO journal 1990;9(1):257-62.
1989: Harry van Steeg; Conny Th M van Oostrom; John Martens; C van Kreyl; J Schepens; B Wieringa
Nucleotide sequence of the human ornithine decarboxylase gene.
Nucleic acids research 1989;17(21):8855-6.
1988: Harry van Steeg; T M van Oostrom; Henk J van Kranen; Coen F van Kreijl
Nucleotide sequence of the rat ornithine decarboxylase gene.
Nucleic acids research 1988;16(16):8173-4.
1985: M M Salimans; H A van Heugten; Harry van Steeg; Harry O Voorma
The effect of serum deprivation on the initiation of protein synthesis in mouse neuroblastoma cells.
Biochimica et biophysica acta 1985;824(1):16-26.
1984: B Setyono; Harry van Steeg; Harry O Voorma
Ultraviolet-crosslinking reveals specific affinity of eukaryotic initiation factors for Semliki Forest virus mRNA.
Biochimica et biophysica acta 1984;782(3):242-6.
1984: Harry van Steeg; M Kasperaitis; Harry O Voorma; Rob Benne
Infection of neuroblastoma cells by Semliki Forest virus. The interference of viral capsid protein with the binding of host messenger RNAs into initiation complexes is the cause of the shut-off of host protein synthesis.
European journal of biochemistry / FEBS 1984;138(3):473-8.
1981: Harry van Steeg; M van Grinsven; F van Mansfeld; Harry O Voorma; Rob Benne
Initiation of protein synthesis in neuroblastoma cells infected by Semliki Forest Virus. A decreased requirement of late viral mRNA for eIF-4B and cap binding protein.
FEBS letters 1981;129(1):62-6.
1981: Harry van Steeg; A Thomas; S Verbeek; M Kasperaitis; Harry O Voorma; Rob Benne
Shutoff of neuroblastoma cell protein synthesis by Semliki Forest virus: loss of ability of crude initiation factors to recognize early Semliki Forest virus and host mRNA's.
Journal of virology 1981;38(2):728-36.
1980: A Thomas; Willy Spaan; Harry van Steeg; Harry O Voorma; Rob Benne
Mode of action of protein synthesis initiation factor eIF-1 from rabbit reticulocytes.
FEBS letters 1980;116(1):67-71.