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Kristel van Steen

Research Profile

Disorders

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Filomeen Haerynck; Bart Loeys; J M Mahachie John; Petra Schelstraete; Sabine Van Daele; Kristel van Steen; M Van Thielen; T Cattaert; K Claes; I De Canck; Frans De Baets
Polymorphisms in the lectin pathway genes as a possible cause of early chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients.
Hugues Aschard; Nilanjan Chatterjee; Eric J Duell; Tasha E Fingerlin; Peter Kraft; Sharon Lutz; Bärbel Maus; Kristel van Steen
Challenges and opportunities in genome-wide environmental interaction (GWEI) studies.
Lizzy De Lobel; Tatiana Kouznetsova; Jan A Staessen; Lutgarde Thijs; Kristel van Steen
A family-based association test to detect gene-gene interactions in the presence of linkage.

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All Publications

2012: Filomeen Haerynck; Bart Loeys; J M Mahachie John; Petra Schelstraete; Sabine Van Daele; Kristel van Steen; M Van Thielen; T Cattaert; K Claes; I De Canck; Frans De Baets
Polymorphisms in the lectin pathway genes as a possible cause of early chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients.
Human immunology 2012;73(11):1175-83.
2012: Hugues Aschard; Nilanjan Chatterjee; Eric J Duell; Tasha E Fingerlin; Peter Kraft; Sharon Lutz; Bärbel Maus; Kristel van Steen
Challenges and opportunities in genome-wide environmental interaction (GWEI) studies.
Human genetics 2012;131(10):1591-613.
2012: Lizzy De Lobel; Tatiana Kouznetsova; Jan A Staessen; Lutgarde Thijs; Kristel van Steen
A family-based association test to detect gene-gene interactions in the presence of linkage.
European journal of human genetics : EJHG 2012;20(9):973-80.
2012: Claus Bachert; Jean Bousquet; Roland Buhl; Tom Cattaert; Gabriele Holtappels; Stephanie Korn; Marek Kowalski; Bärbel Maus; Christian Taube; Kristel van Steen; Nan Zhang; Peter Howarth
Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma.
The Journal of allergy and clinical immunology 2012;130(2):376-81.e8.
2012: L Márquez; S Organe; C Perrier; Paul Rutgeerts; C Shen; Kristel van Steen; V Ballet; Jan L Ceuppens; I Cleynen; Gert De Hertogh; Marc Ferrante; G Galicia; Liesbet Henckaerts; K Machiels; Severine Vermeire
Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis.
Gut 2012;61(4):528-34.
2012: Karin C Lødrup Carlsen; Jestinah M Mahachie John; Petter Mowinckel; Carmen Puig; Andreas Reich; Graham Roberts; Stephanie Roll; Ben Spycher; Jordi Sunyer; Maties Torrent; Kristel van Steen; Andrea von Berg; Ulrich Wahn; Alet Wijga; Stefan N Willich; S Hasan Arshad; Anna Asarnoj; Bert Brunekreef; Kai-Håkon Carlsen; Chih-Mei Chen; Esben Eller; Olf Herbarth; Arne Høst; Thomas Keil; Ursula Krämer; Claudia Kuehni; Inger Kull; Susanne Lau
Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts.
PloS one 2012;7(8):e43214.
2011: Philippe Gevaert; Richard P Marshall; Ana R Sousa; Nicholas Van Bruaene; Kristel van Steen; Thibaut Van Zele; Frederic Acke; Katrien Blomme; Tom Cattaert; Natalie De Ruyck; Claus Bachert
Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis.
The Journal of allergy and clinical immunology 2011;128(5):989-95.e1-8.
2011: Fabian Schnitzler; Bernard Spitz; Gert van Assche; Kristel van Steen; Séverine Vermeire; Vera Ballet; Marc Ferrante; Herma Fidder; Ilse Hoffman; Maja Noman; Paul Rutgeerts
Outcome of pregnancy in women with inflammatory bowel disease treated with antitumor necrosis factor therapy.
Inflammatory bowel diseases 2011;17(9):1846-54.
2011: Liesbet Henckaerts; Isabelle Cleynen; Marko Brinar; Jestinah Mahachie John; Kristel van Steen; Paul Rutgeerts; Séverine Vermeire
Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease.
Inflammatory bowel diseases 2011;17(6):1392-7.
2011: Jestinah M Mahachie John; François Van Lishout; Kristel van Steen
Model-Based Multifactor Dimensionality Reduction to detect epistasis for quantitative traits in the presence of error-free and noisy data.
European journal of human genetics : EJHG 2011;19(6):696-703.
2011: Matthias Jürgens; Jestinah M Mahachie John; Isabelle Cleynen; Fabian Schnitzler; Herma Fidder; Wouter van Moerkercke; Vera Ballet; Maja Noman; Ilse Hoffman; Gert van Assche; Paul J Rutgeerts; Kristel van Steen; Severine Vermeire
Levels of C-reactive protein are associated with response to infliximab therapy in patients with Crohn's disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2011;9(5):421-7.e1.
2011: Christine Breynaert; Marc Ferrante; Herma Fidder; Kristel van Steen; Maja Noman; Vera Ballet; Séverine Vermeire; Paul Rutgeerts; Gert van Assche
Tolerability of shortened infliximab infusion times in patients with inflammatory bowel diseases: a single-center cohort study.
The American journal of gastroenterology 2011;106(4):778-85.
2011: Ingrid Arijs; Gert De Hertogh; Kathleen Machiels; Kristel van Steen; Katleen Lemaire; Anica Schraenen; Leentje Van Lommel; Roel Quintens; Gert van Assche; Séverine Vermeire; Frans Schuit; Paul Rutgeerts
Mucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment.
The American journal of gastroenterology 2011;106(4):748-61.
2011: Marie Joossens; Geert Huys; Kristel van Steen; Margo Cnockaert; Séverine Vermeire; Paul Rutgeerts; Kristin Verbeke; Peter Vandamme; Vicky De Preter
High-throughput method for comparative analysis of denaturing gradient gel electrophoresis profiles from human fecal samples reveals significant increases in two bifidobacterial species after inulin-type prebiotic intake.
FEMS microbiology ecology 2011;75(2):343-9.
2011: Jestinah M Mahachie John; François Van Lishout; Tom Cattaert; Lizzy De Lobel; Alain Empain; Kristel van Steen
Comparison of genetic association strategies in the presence of rare alleles.
BMC proceedings 2011;5 Suppl 9():S32.
2011: Tom Cattaert; M Luz Calle; Scott M Dudek; Jestinah M Mahachie John; François Van Lishout; Victor Urrea; Marylyn Ritchie; Kristel van Steen
Model-based multifactor dimensionality reduction for detecting epistasis in case-control data in the presence of noise.
Annals of human genetics 2011;75(1):78-89.
2010: Ingrid Arijs; Roel Quintens; Leentje Van Lommel; Kristel van Steen; Gert De Hertogh; Katleen Lemaire; Anica Schraenen; Clémentine Perrier; Gert van Assche; Séverine Vermeire; Karel Geboes; Frans Schuit; Paul Rutgeerts
Predictive value of epithelial gene expression profiles for response to infliximab in Crohn's disease.
Inflammatory bowel diseases 2010;16(12):2090-8.
2010: Claus Bachert; Nan Zhang; Gabriele Holtappels; Lizzy De Lobel; Paul van Cauwenberge; Shixi Liu; Ping Lin; Jean Bousquet; Kristel van Steen
Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
The Journal of allergy and clinical immunology 2010;126(5):962-8, 968.e1-6.
2010: Lizzy De Lobel; Pierre Geurts; Guy Baele; Francesc Castro-Giner; Manolis Kogevinas; Kristel van Steen
A screening methodology based on Random Forests to improve the detection of gene-gene interactions.
European journal of human genetics : EJHG 2010;18(10):1127-32.
2010: Robyn T Cohen; Benjamin A Raby; Kristel van Steen; Anne L Fuhlbrigge; Juan C Celedón; Bernard A Rosner; Robert C Strunk; Robert S Zeiger; Scott T Weiss
In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma.
The Journal of allergy and clinical immunology 2010;126(3):491-7.
2010: M Luz Calle; Víctor Urrea; Núria Malats; Kristel van Steen
mbmdr: an R package for exploring gene-gene interactions associated with binary or quantitative traits.
Bioinformatics (Oxford, England) 2010;26(17):2198-9.
2010: Isabelle Cleynen; Jestinah M Mahachie John; Liesbet Henckaerts; Wouter Van Moerkercke; Paul Rutgeerts; Kristel van Steen; Severine Vermeire
Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.
PloS one 2010;5(9):e12952.
2010: Marie Joossens; Kristel van Steen; Julien Branche; Boualem Sendid; Paul Rutgeerts; Francis Vasseur; Daniel Poulain; Franck Broly; Jean-Frédéric Colombel; Severine Vermeire; Mathias Chamaillard
Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohn's disease.
Inflammatory bowel diseases 2010;16(1):58-67.
2009: I Arijs; K Li; G Toedter; R Quintens; L Van Lommel; Kristel van Steen; P Leemans; Gert De Hertogh; K Lemaire; Marc Ferrante; F Schnitzler; Lieven Thorrez; K Ma; X-Y R Song; C Marano; Gert van Assche; Severine Vermeire; Karel Geboes; F Schuit; F Baribaud; Paul Rutgeerts
Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis.
Gut 2009;58(12):1612-9.
2009: Liesbet Henckaerts; Kristel van Steen; Isabel Verstreken; Isabelle Cleynen; Andre Franke; Stefan Schreiber; Paul Rutgeerts; Severine Vermeire
Genetic risk profiling and prediction of disease course in Crohn's disease patients.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2009;7(9):972-980.e2.
2009: Fabian Schnitzler; Herma Fidder; Marc Ferrante; Maja Noman; Ingrid Arijs; Gert van Assche; Ilse Hoffman; Kristel van Steen; Severine Vermeire; Paul Rutgeerts
Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn's disease.
Inflammatory bowel diseases 2009;15(9):1295-301.
2009: Veerle Bogaert; Griet Vanbillemont; Youri E C Taes; Dirk De Bacquer; Ellen Deschepper; Kristel van Steen; Jean-Marc Kaufman
Small effect of the androgen receptor gene GGN repeat polymorphism on serum testosterone levels in healthy men.
European journal of endocrinology / European Federation of Endocrine Societies 2009;161(1):171-7.
2009: F Schnitzler; H Fidder; Marc Ferrante; Maja Noman; I Arijs; Gert van Assche; Ilse Hoffman; Kristel van Steen; Severine Vermeire; Paul Rutgeerts
Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: results from a single-centre cohort.
Gut 2009;58(4):492-500.
2009: Griet Vanbillemont; Veerle Bogaert; Dirk De Bacquer; Bruno Lapauw; Stefan Goemaere; Kaatje Toye; Kristel van Steen; Youri E C Taes; Jean-Marc Kaufman
Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men.
Clinical endocrinology 2009;70(2):303-10.
2009: Ingrid Arijs; Gert De Hertogh; Katleen Lemaire; Roel Quintens; Leentje Van Lommel; Kristel van Steen; Peter Leemans; Isabelle Cleynen; Gert van Assche; Severine Vermeire; Karel Geboes; Frans Schuit; Paul Rutgeerts
Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment.
PloS one 2009;4(11):e7984.
2009: Benjamin A Raby; Kristel van Steen; Jessica Lasky-Su; Kelan G Tantisira; Feige Kaplan; Scott Weiss
Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma.
Respiratory research 2009;10():67.
2009: Liesbet Henckaerts; Kaspar R Nielsen; Rudi Steffensen; Kristel van Steen; Chantal Mathieu; Annapaula Giulietti; Pieter J Wouters; Ilse Milants; Ilse Vanhorebeek; Lies Langouche; Séverine Vermeire; Paul Rutgeerts; Steffen Thiel; Alexander Wilmer; Troels Krarup Hansen; Greet Van den Berghe
Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit.
Critical care medicine 2009;37(1):192-201, e1-3.
2008: Marc Ferrante; Séverine Vermeire; Herma Fidder; Fabian Schnitzler; Maja Noman; Gert van Assche; Gert De Hertogh; Ilse Hoffman; Andre D'Hoore; Kristel van Steen; Karel Geboes; Freddy Penninckx; Paul Rutgeerts
Long-term outcome after infliximab for refractory ulcerative colitis.
Journal of Crohn's & colitis 2008;2(3):219-25.
2008: Veerle Bogaert; Youri Taes; Peter Konings; Kristel van Steen; Dirk De Bacquer; Stefan Goemaere; Hans Zmierczak; Patricia Crabbe; Jean-Marc Kaufman
Heritability of blood concentrations of sex-steroids in relation to body composition in young adult male siblings.
Clinical endocrinology 2008;69(1):129-35.
2007: Marc Ferrante; Liesbet Henckaerts; Marie Joossens; Marie Pierik; Sofie Joossens; Nir Dotan; Gary L Norman; Rom Altstock; Kristel van Steen; Paul Rutgeerts; Gert van Assche; Severine Vermeire
New serological markers in inflammatory bowel disease are associated with complicated disease behaviour.
Gut 2007;56(10):1394-403.
2007: Kristel van Steen; N M Laird; Paul Markel; G Molenberghs
Approaches to handling incomplete data in family-based association testing.
Annals of human genetics 2007;71(Pt 2):141-51.
2006: Benjamin A Raby; Kristel van Steen; Ross Lazarus; Juan C Celedón; Edwin K Silverman; Scott Weiss
Eotaxin polymorphisms and serum total IgE levels in children with asthma.
The Journal of allergy and clinical immunology 2006;117(2):298-305.
2006: Marie Pierik; Sofie Joossens; Kristel van Steen; Nele Van Schuerbeek; Robert Francois Vlietinck; Paul Rutgeerts; Severine Vermeire
Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.
Inflammatory bowel diseases 2006;12(1):1-8.
2006: Fabio Efficace; andrew bottomley; Corneel Coens; Kristel van Steen; Thierry Conroy; Patrick Schöffski; Hans Schmoll; Eric Van Cutsem; Claus-Henning Köhne
Does a patient's self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?
European journal of cancer (Oxford, England : 1990) 2006;42(1):42-9.
2006: Benjamin A Raby; Eun-Sook Hwang; Kristel van Steen; Kelan G Tantisira; Stanford Peng; Augusto A Litonjua; Ross Lazarus; Cosmas Giallourakis; John D Rioux; David Sparrow; Edwin K Silverman; Laurie H Glimcher; Scott Weiss
T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.
American journal of respiratory and critical care medicine 2006;173(1):64-70.
2005: Beatrijs Moerkerke; Els Goetghebeur; Kristel van Steen; Simon Van Belle; Veronique Cocquyt
Permutation based methods for comparing quality of life between observed treatments.
Statistics in medicine 2005;24(24):4055-66.
2005: Benjamin A Raby; Kristel van Steen; Juan C Celedón; Augusto A Litonjua; Christoph Lange; Scott Weiss
Paternal history of asthma and airway responsiveness in children with asthma.
American journal of respiratory and critical care medicine 2005;172(5):552-8.
2005: Kristel van Steen; Matthew B McQueen; Alan Herbert; Benjamin A Raby; Helen N Lyon; Dawn L DeMeo; Amy Murphy; Jessica Su; Soma Datta; Carsten Rosenow; Michael F Christman; Edwin K Silverman; Nan M Laird; Scott Weiss; Christoph Lange
Genomic screening and replication using the same data set in family-based association testing.
Nature genetics 2005;37(7):683-91.
2005: Marc Van Ranst; Marie Joossens; Sofie Joossens; Kristel van Steen; Marie Pierik; Severine Vermeire; Paul Rutgeerts
Crohn's disease and month of birth.
Inflammatory bowel diseases 2005;11(6):597-9.
2005: Kristel van Steen; Christoph Lange
PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies.
Human genomics 2005;2(1):67-9.
2005: Matthew B McQueen; Amy Murphy; Peter Kraft; Jessica Su; Ross Lazarus; Nan M Laird; Christoph Lange; Kristel van Steen
Comparison of linkage and association strategies for quantitative traits using the COGA dataset.
BMC genetics 2005;6 Suppl 1():S96.
2005: Amy Murphy; Matthew B McQueen; Jessica Su; Peter Kraft; Ross Lazarus; Nan M Laird; Christoph Lange; Kristel van Steen
Genomic screening in family-based association testing.
BMC genetics 2005;6 Suppl 1():S115.
2004: Sofie Joossens; Severine Vermeire; Kristel van Steen; Godelieve Godefridis; Greet Claessens; Marie Pierik; Robert Francois Vlietinck; Raymond Aerts; Paul Rutgeerts; Xavier Bossuyt
Pancreatic autoantibodies in inflammatory bowel disease.
Inflammatory bowel diseases 2004;10(6):771-7.
2004: Fabio Efficace; Patrick Therasse; Martine J Piccart; Corneel Coens; Kristel van Steen; Marzena Welnicka-Jaskiewicz; Tanja Cufer; Jaroslaw Dyczka; Michail R Lichinitser; Lois Shepherd; Hanneke de Haes; Mirjam A G Sprangers; andrew bottomley
Health-related quality of life parameters as prognostic factors in a nonmetastatic breast cancer population: an international multicenter study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(16):3381-8.
2004: Sofie Joossens; Marco Daperno; Zakera Shums; Kristel van Steen; James A Goeken; Claudio Trapani; Gary L Norman; Godelieve Godefridis; Greet Claessens; Angelo Pera; Marie Pierik; Severine Vermeire; Paul Rutgeerts; Xavier Bossuyt
Interassay and interobserver variability in the detection of anti-neutrophil cytoplasmic antibodies in patients with ulcerative colitis.
Clinical chemistry 2004;50(8):1422-5.
2004: Denis Franchimont; Severine Vermeire; Hakim El Housni; Marie Pierik; Kristel van Steen; Thierry Gustot; Eric Quertinmont; M Abramowicz; André Van Gossum; Jacques Devière; Paul Rutgeerts
Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis.
Gut 2004;53(7):987-92.
2004: Severine Vermeire; Paul Rutgeerts; Kristel van Steen; Sofie Joossens; Greet Claessens; Marie Pierik; M Peeters; Robert Francois Vlietinck
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis.
Gut 2004;53(7):980-6.
2004: Fabio Efficace; Laura Biganzoli; Martine Piccart; Corneel Coens; Kristel van Steen; Tanja Cufer; R E Coleman; Hilary Calvert; Teresa Gamucci; Chris Twelves; Pierre Fargeot; andrew bottomley
Baseline health-related quality-of-life data as prognostic factors in a phase III multicentre study of women with metastatic breast cancer.
European journal of cancer (Oxford, England : 1990) 2004;40(7):1021-30.
2004: Nele Esters; Marie Pierik; Kristel van Steen; Severine Vermeire; Greet Claessens; Sofie Joossens; Robert Francois Vlietinck; Paul Rutgeerts
Transmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease.
The American journal of gastroenterology 2004;99(2):299-305.
2004: Christoph Lange; Kristel van Steen; Toby Andrew; Helen N Lyon; Dawn L DeMeo; Benjamin A Raby; Amy Murphy; Edwin K Silverman; Alex MacGregor; Scott Weiss; Nan M Laird
A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects.
Statistical applications in genetics and molecular biology 2004;3():Article17.
2003: Severine Vermeire; Maja Noman; Gert van Assche; Filip Baert; Kristel van Steen; Nele Esters; Sofie Joossens; Xavier Bossuyt; Paul Rutgeerts
Autoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: a prospective cohort study.
Gastroenterology 2003;125(1):32-9.
2003: Ivy Jansen; Geert Molenberghs; Marc Aerts; Herbert Thijs; Kristel van Steen
A local influence approach applied to binary data from a psychiatric study.
Biometrics 2003;59(2):410-9.
2003: andrew bottomley; Ronald Thomas; Kristel van Steen; Henning Flechtner; Alexander de Graeff
Guidelines for the use of epoetin: have quality-of-life benefits been proven?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(11):2223; author reply 2224-5.
2002: Kristel van Steen; Desmond Curran; Jocelyn Kramer; Geert Molenberghs; Ann Van Vreckem; andrew bottomley; Richard Sylvester
Multicollinearity in prognostic factor analyses using the EORTC QLQ-C30: identification and impact on model selection.
Statistics in medicine 2002;21(24):3865-84.
2002: andrew bottomley; Ronald Thomas; Kristel van Steen; Henning Flechtner; Benjamin Djulbegovic
Erythropoietin improves quality of life--a response.
The lancet oncology 2002;3(9):527.
2002: andrew bottomley; Ronald Thomas; Kristel van Steen; Henning Flechtner; Benjamin Djulbegovic
Human recombinant erythropoietin and quality of life: a wonder drug or something to wonder about?
The lancet oncology 2002;3(3):145-53.
2001: Kristel van Steen; Desmond Curran; Geert Molenberghs
Sensitivity analysis of longitudinal binary quality of life data with drop-out: an example using the EORTC QLQ-C30.
Statistics in medicine 2001;20(24):3901-20.