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Paul Van Veldhoven

Research Profile

Anatomy

Living Beings

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Oxidation-Reduction

Chemicals & Drugs

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Amino Acid Sequences

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Zellweger's Syndrome

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Katrin Martens; Annelies Peeters; Paul P Van Veldhoven; Astrid Bottelbergs; Peter Carmeliet; Marc Espeel; Frank Jacobs; Myriam Baes
Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone.
Myriam Baes; Paul P Van Veldhoven
Mouse models for peroxisome biogenesis defects and β-oxidation enzyme deficiencies.
M Nordgren; B Wang; Paul P Van Veldhoven; O Apanasets; Chantal Brees; Marc Fransen
Potential limitations in the use of KillerRed for fluorescence microscopy.

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2012: Katrin Martens; Annelies Peeters; Paul P Van Veldhoven; Astrid Bottelbergs; Peter Carmeliet; Marc Espeel; Frank Jacobs; Myriam Baes
Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone.
Molecular genetics and metabolism 2012;107(4):735-47.
2012: Myriam Baes; Paul P Van Veldhoven
Mouse models for peroxisome biogenesis defects and β-oxidation enzyme deficiencies.
Biochimica et biophysica acta 2012;1822(9):1489-500.
2012: M Nordgren; B Wang; Paul P Van Veldhoven; O Apanasets; Chantal Brees; Marc Fransen
Potential limitations in the use of KillerRed for fluorescence microscopy.
Journal of microscopy 2012;245(3):229-35.
2012: Ester Reina; Paul P Van Veldhoven; Luz Camacho; Josefina Casas; Gemma Fabrias
Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry.
Chemistry and physics of lipids 2012;165(2):225-31.
2012: Yingmei Feng; Rachel Geenens; Paul Herijgers; Paul Holvoet; Sarah Schouteden; Vik Van Duppen; Paul P Van Veldhoven; Catherine M Verfaillie
Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in mice.
PloS one 2012;7(11):e47286.
2012: Helena Van Overloop; Gerd Van der Hoeven; Paul P Van Veldhoven
A Nonradioactive Fluorimetric SPE-Based Ceramide Kinase Assay Using NBD-C(6)-Ceramide.
Journal of lipids 2012;2012():404513.
2012: Astrid Bottelbergs; Rita Devos; Wilhelm Just; Paul P Van Veldhoven; Simon Verheijden; Myriam Baes
Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system.
Journal of neuroinflammation 2012;9():61.
2011: Annelies Peeters; Mark H Rider; Hiroshi Takemori; Sjoerd van den Berg; Ko Willems van Dijk; Antoine Van Kampen; Paul P Van Veldhoven; Emiel Ver Loren van Themaat; Peter Carmeliet; Peter Fraisl; Myriam Baes
Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression.
The Journal of biological chemistry 2011;286(49):42162-79.
2011: Valérie Van der Eecken; Paul P Van Veldhoven; André Clippe; Bernard Knoops
Mitochondrial targeting of peroxiredoxin 5 is preserved from annelids to mammals but is absent in pig Sus scrofa domesticus.
Mitochondrion 2011;11(6):973-81.
2011: Annelies Peeters; Johannes V Swinnen; Paul P Van Veldhoven; Myriam Baes
Hepatosteatosis in peroxisome deficient liver despite increased β-oxidation capacity and impaired lipogenesis.
Biochimie 2011;93(10):1828-38.
2011: Patrizia Fraccascia; Minne Casteels; Evelyn De Schryver; Paul P Van Veldhoven
Role of thiamine pyrophosphate in oligomerisation, functioning and import of peroxisomal 2-hydroxyacyl-CoA lyase.
Biochimica et biophysica acta 2011;1814(10):1226-33.
2011: Alan S Lewis; Zhiqiang Liu; Daniel A Nicholson; Andrey B Popov; Craig M Powell; Travis R Stoub; Sachin P Vaidya; Paul P Van Veldhoven; Douglas A Bayliss; Roland A Bender; Cory A Blaiss; Darrin H Brager; Xiangdong Chen; Chad M Estep; Daniel Johnston; Catherine E Kang; Dane M Chetkovich
Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(20):7424-40.
2011: Oksana Ivashchenko; Paul P Van Veldhoven; Chantal Brees; Ye-Shih Ho; Stanley R Terlecky; Marc Fransen
Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk.
Molecular biology of the cell 2011;22(9):1440-51.
2011: Ilse Vandecaetsbeek; Søren Brøgger Christensen; Huizhen Liu; Paul P Van Veldhoven; Etienne Waelkens; Jan Eggermont; Luc Raeymaekers; Jesper V Møller; Poul Nissen; Frank Wuytack; Peter Vangheluwe
Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases.
Biochimica et biophysica acta 2011;1813(5):1118-27.
2011: Laura Trovò; Paul P Van Veldhoven; Mauricio G Martín; Carlos G Dotti
Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis.
Journal of cell science 2011;124(Pt 8):1308-15.
2011: Miao He; Zhengtong Pei; Al-Walid Mohsen; Paul A Watkins; Geoffrey Murdoch; Paul P Van Veldhoven; Regina Ensenauer; Jerry Vockley
Identification and characterization of new long chain acyl-CoA dehydrogenases.
Molecular genetics and metabolism 2011;102(4):418-29.
2010: Karen Van Proeyen; Karolina Szlufcik; Henri Nielens; Koen Pelgrim; Louise Deldicque; Matthijs K C Hesselink; Paul P Van Veldhoven; Peter Hespel
Training in the fasted state improves glucose tolerance during fat-rich diet.
The Journal of physiology 2010;588(Pt 21):4289-302.
2010: Evelien Rysman; Koen Brusselmans; Katryn Scheys; Leen Timmermans; Rita Derua; Sebastian Munck; Paul P Van Veldhoven; David Waltregny; Veerle W Daniëls; Jelle Machiels; Frank Vanderhoydonc; Karine Smans; Etienne Waelkens; Guido Verhoeven; Johannes V Swinnen
De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation.
Cancer research 2010;70(20):8117-26.
2010: Paul P Van Veldhoven
Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism.
Journal of lipid research 2010;51(10):2863-95.
2010: Yoshinori Kashiwayama; Takenori Tomohiro; Kotomi Narita; Miyuki Suzumura; Tuomo Glumoff; J Kalervo Hiltunen; Paul P Van Veldhoven; Yasumaru Hatanaka; Tsuneo Imanaka
Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative.
The Journal of biological chemistry 2010;285(34):26315-25.
2010: Ralf Frederik Claas; Michael ter Braak; Bianca Hegen; Verena Hardel; Carlo Angioni; Helmut Schmidt; Karl H Jakobs; Paul P Van Veldhoven; Dagmar Meyer zu Heringdorf
Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts.
Cellular signalling 2010;22(3):476-83.
2010: Audrey Extier; Bénédicte Langelier; Marie-Hélène Perruchot; Philippe Guesnet; Paul P Van Veldhoven; Monique Lavialle; Jean-Marc Alessandri
Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion.
The Journal of nutritional biochemistry 2010;21(3):180-7.
2009: Sandra Colié; Paul P Van Veldhoven; Blandine Kedjouar; Carmen Bedia; Virginie Albinet; Sonia-Caroline Sorli; Virginie Garcia; Mojgan Djavaheri-Mergny; Chantal Bauvy; Patrice Codogno; Thierry Levade; Nathalie Andrieu-Abadie
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation.
Cancer research 2009;69(24):9346-53.
2009: Sofie J Huybrechts; Paul P Van Veldhoven; Chantal Brees; Guy P Mannaerts; Georgyi V Los; Marc Fransen
Peroxisome dynamics in cultured mammalian cells.
Traffic (Copenhagen, Denmark) 2009;10(11):1722-33.
2009: Claudia Weber; Andreas Krueger; Anika Münk; Constantin Bode; Paul P Van Veldhoven; Markus H Gräler
Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4292-301.
2009: Nadine Hagen; Paul P Van Veldhoven; Richard L Proia; Hyejung Park; Alfred H Merrill; Gerhild van Echten-Deckert
Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons.
The Journal of biological chemistry 2009;284(17):11346-53.
2009: Carmen Bedia; Luz Camacho; Josefina Casas; José Luis Abad; Antonio Delgado; Paul P Van Veldhoven; Gemma Fabriàs
Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity.
Chembiochem : a European journal of chemical biology 2009;10(5):820-2.
2009: Sofie J Huybrechts; Jaak Jaeken; Paul P Van Veldhoven; Renate Zeevaert; Rita De Vos; Philippe Demaerel; Marc Fransen; Ilse Hoffman; Marijke Brams; David Cassiman
Identification of a novel PEX14 mutation in Zellweger syndrome.
BMJ case reports 2009;2009():.
2009: Karine Hellemans; Jean Claude Hannaert; Bart Denys; Knut R Steffensen; Cindy Raemdonck; Geert A Martens; Paul P Van Veldhoven; Jan-Ake Gustafsson; Daniel Pipeleers
Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.
PloS one 2009;4(9):e7266.
2009: Erin A Anthonio; Chantal Brees; Eveline Baumgart-Vogt; Tsunaki Hongu; Sofie J Huybrechts; Patrick Van Dijck; Guy P Mannaerts; Yasunori Kanaho; Paul P Van Veldhoven; Marc Fransen
Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6.
BMC cell biology 2009;10():58.
2009: Paola G Camoletto; Hugo Vara; Laura Morando; Emma Connell; Fabio P Marletto; Maurizio Giustetto; Marco Sassoe-Pognetto; Paul P Van Veldhoven; Maria Dolores Ledesma
Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18.
PloS one 2009;4(4):e5310.
2008: Katrin Martens; Emiel Ver Loren van Themaat; Marinus F van Batenburg; Merja Heinäniemi; Steven Huyghe; Paul van Hummelen; Carsten Carlberg; Paul P Van Veldhoven; Antoine Van Kampen; Myriam Baes
Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice.
Biochimica et biophysica acta 2008;1781(11-12):694-702.
2008: Su Duy Nguyen; Myriam Baes; Paul P Van Veldhoven
Degradation of very long chain dicarboxylic polyunsaturated fatty acids in mouse hepatocytes, a peroxisomal process.
Biochimica et biophysica acta 2008;1781(8):400-5.
2008: Ulrike Peest; Sven-Christian Sensken; Paul Andréani; Petra Hänel; Paul P Van Veldhoven; Markus H Gräler
S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake.
Journal of cellular biochemistry 2008;104(3):756-72.
2008: Marc Fransen; Leen Amery; Andreas Hartig; Chantal Brees; Anja Rabijns; Guy P Mannaerts; Paul P Van Veldhoven
Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b.
Biochimica et biophysica acta 2008;1783(5):864-73.
2008: Leen Hulshagen; Olga Krysko; Astrid Bottelbergs; Steven Huyghe; Rüdiger Klein; Paul P Van Veldhoven; Peter P De Deyn; Rudi D'Hooge; Dieter Hartmann; Myriam Baes
Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(15):4015-27.
2008: Christine Graf; Barbara Zemann; Philipp Rovina; Nicole Urtz; Andrea Helga Schanzer; Roland Reuschel; Diana Mechtcheriakova; Matthias Müller; Evelin Fischer; Claudia Reichel; Susanna Huber; Janet Dawson; Josef G Meingassner; Andreas Billich; Satoru Niwa; Rudolf Badegruber; Paul P Van Veldhoven; Bernd Kinzel; Thomas Baumruker; Frédéric Bornancin
Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3457-66.
2008: Cristian Galvan; Paola G Camoletto; Flavio Cristofani; Paul P Van Veldhoven; Maria Dolores Ledesma
Anomalous surface distribution of glycosyl phosphatidyl inositol-anchored proteins in neurons lacking acid sphingomyelinase.
Molecular biology of the cell 2008;19(2):509-22.
2007: Helena Van Overloop; Paul P Van Veldhoven
Ceramide-dependent release of ceramide kinase from cultured cells.
Biochemical and biophysical research communications 2007;364(1):169-74.
2007: Karine Hellemans; Karen Kerckhofs; Jean-Claude Hannaert; Geert Martens; Paul P Van Veldhoven; Daniel Pipeleers
Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity.
The FEBS journal 2007;274(23):6094-105.
2007: Minne Casteels; Mieke Sniekers; P Fraccascia; Guy P Mannaerts; Paul P Van Veldhoven
The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids.
Biochemical Society transactions 2007;35(Pt 5):876-80.
2007: David Oaxaca-Castillo; Pierre Andreoletti; Aurore Vluggens; Sangtao Yu; Paul P Van Veldhoven; Janardan K Reddy; Mustapha Cherkaoui Malki
Biochemical characterization of two functional human liver acyl-CoA oxidase isoforms 1a and 1b encoded by a single gene.
Biochemical and biophysical research communications 2007;360(2):314-9.
2007: Junxia Min; Adi Mesika; Mayandi Sivaguru; Paul P Van Veldhoven; Hannah Alexander; Anthony H Futerman; Stephen Alexander
(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1.
Molecular cancer research : MCR 2007;5(8):801-12.
2007: Koen Brusselmans; Leen Timmermans; Tine Van de Sande; Paul P Van Veldhoven; Guimin Guan; Ishaiahu Shechter; Frank Claessens; Guido Verhoeven; Johannes V Swinnen
Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.
The Journal of biological chemistry 2007;282(26):18777-85.
2007: Ruud Dirkx; Els Meyhi; Stanny Asselberghs; Janardan Reddy; Myriam Baes; Paul P Van Veldhoven
Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts.
Biochemical and biophysical research communications 2007;357(3):718-23.
2007: Helena Van Overloop; Yves Denizot; Myriam Baes; Paul P Van Veldhoven
On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase.
Biological chemistry 2007;388(3):315-24.
2007: Patrizia Fraccascia; Mieke Sniekers; Minne Casteels; Paul P Van Veldhoven
Presence of thiamine pyrophosphate in mammalian peroxisomes.
BMC biochemistry 2007;8():10.
2006: Myriam Baes; Paul P Van Veldhoven
Generalised and conditional inactivation of Pex genes in mice.
Biochimica et biophysica acta 2006;1763(12):1785-93.
2006: Steven Huyghe; Guy P Mannaerts; Myriam Baes; Paul P Van Veldhoven
Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model.
Biochimica et biophysica acta 2006;1761(9):973-94.
2006: Ilse Vastiau; E A Anthonio; M Brams; Chantal Brees; S G Young; Sam Van de Velde; R J A Wanders; Guy P Mannaerts; Myriam Baes; Paul P Van Veldhoven; Marc Fransen
Farnesylation of Pex19p is not essential for peroxisome biogenesis in yeast and mammalian cells.
Cellular and molecular life sciences : CMLS 2006;63(14):1686-99.
2006: Mieke Sniekers; Veerle Foulon; Guy P Mannaerts; L Van Maldergem; H Mandel; B D Gelb; Minne Casteels; Paul P Van Veldhoven
Thiamine pyrophosphate: an essential cofactor for the alpha-oxidation in mammals--implications for thiamine deficiencies?
Cellular and molecular life sciences : CMLS 2006;63(13):1553-63.
2006: Steven Huyghe; Henning Schmalbruch; Karel De Gendt; Guido Verhoeven; Florian Guillou; Paul P Van Veldhoven; Myriam Baes
Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice.
Endocrinology 2006;147(5):2228-36.
2006: Helena Van Overloop; Sofie Gijsbers; Paul P Van Veldhoven
Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies.
Journal of lipid research 2006;47(2):268-83.
2005: Sacha Ferdinandusse; Simone Denis; Henk Overmars; Lisbeth Van Eeckhoudt; Paul P Van Veldhoven; Marinus Duran; Ronald J A Wanders; Myriam Baes
Developmental changes of bile acid composition and conjugation in L- and D-bifunctional protein single and double knockout mice.
The Journal of biological chemistry 2005;280(19):18658-66.
2005: Junxia Min; Paul P Van Veldhoven; Lei Zhang; Marie H Hanigan; Hannah Alexander; Stephen Alexander
Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner.
Molecular cancer research : MCR 2005;3(5):287-96.
2005: Helena Van Overloop; Gerd Van der Hoeven; Paul P Van Veldhoven
N-acyl migration in ceramides.
Journal of lipid research 2005;46(4):812-6.
2005: Ruud Dirkx; Ilse Vanhorebeek; Katrin Martens; Arno Schad; Markus Grabenbauer; Dariush Fahimi; Peter E Declercq; Paul P Van Veldhoven; Myriam Baes
Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities.
Hepatology (Baltimore, Md.) 2005;41(4):868-78.
2005: Veerle Foulon; Mieke Sniekers; Els Huysmans; Stanny Asselberghs; Vincent Mahieu; Guy P Mannaerts; Paul P Van Veldhoven; Minne Casteels
Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids.
The Journal of biological chemistry 2005;280(11):9802-12.
2005: Marc Fransen; Ilse Vastiau; Chantal Brees; Vanessa Brys; Guy P Mannaerts; Paul P Van Veldhoven
Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis.
Journal of molecular biology 2005;346(5):1275-86.
2005: Peter J Hanley; Stefan Dröse; Ulrich Brandt; Rachel A Lareau; Abir L Banerjee; DK Srivastava; Leonard J Banaszak; Joseph J Barycki; Paul P Van Veldhoven; Jürgen Daut
5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids.
The Journal of physiology 2005;562(Pt 2):307-18.
2004: Yasuyoshi Sakai; Hironori Takahashi; Yuori Wakasa; Tetsuya Kotani; Hiroya Yurimoto; Nobuya Miyachi; Paul P Van Veldhoven; Nobuo Kato
Role of alpha-methylacyl coenzyme A racemase in the degradation of methyl-branched alkanes by Mycobacterium sp. strain P101.
Journal of bacteriology 2004;186(21):7214-20.
2004: Marc Fransen; Ilse Vastiau; Chantal Brees; Vanessa Brys; Guy P Mannaerts; Paul P Van Veldhoven
Potential role for Pex19p in assembly of PTS-receptor docking complexes.
The Journal of biological chemistry 2004;279(13):12615-24.
2004: Benjamin J Pettus; Myriam Baes; Mark Busman; Yusuf A Hannun; Paul P Van Veldhoven
Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders.
Rapid communications in mass spectrometry : RCM 2004;18(14):1569-74.
2003: Mary Beth Genter; Paul P Van Veldhoven; anil jegga; Bhuvaneswari Sakthivel; Sue Kong; Kristin Stanley; David P Witte; Catherine L Ebert; Bruce Aronow
Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system.
Physiological genomics 2003;16(1):67-81.
2003: Veerle Foulon; Stanny Asselberghs; Wendy Geens; Guy P Mannaerts; Minne Casteels; Paul P Van Veldhoven
Further studies on the substrate spectrum of phytanoyl-CoA hydroxylase: implications for Refsum disease?
Journal of lipid research 2003;44(12):2349-55.
2003: Yuzhi Jia; Chao Qi; Zhongyi Zhang; Takashi Hashimoto; M Sambasiva Rao; Steven Huyghe; Yasuyuki Suzuki; Paul P Van Veldhoven; Myriam Baes; Janardan K Reddy
Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation system.
The Journal of biological chemistry 2003;278(47):47232-9.
2003: Anneleen Janssen; Pierre Gressens; Markus Grabenbauer; Eveline Baumgart; Arno Schad; Ilse Vanhorebeek; Annelies Brouwers; Peter E Declercq; Dariush Fahimi; Philippe Evrard; Luc Schoonjans; Désiré Collen; Peter Carmeliet; Guy P Mannaerts; Paul P Van Veldhoven; Myriam Baes
Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(30):9732-41.
2003: Michael Beil; Alexandre Micoulet; Goetz von Wichert; Stephan Paschke; Paul Walther; Bishr Omary; Paul P Van Veldhoven; Ulrike Gern; Elke Wolff-Hieber; Juliane Eggermann; Johannes Waltenberger; Guido Adler; Joachim P Spatz; Thomas Seufferlein
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells.
Nature cell biology 2003;5(9):803-11.
2003: Minne Casteels; Veerle Foulon; Guy P Mannaerts; Paul P Van Veldhoven
Alpha-oxidation of 3-methyl-substituted fatty acids and its thiamine dependence.
European journal of biochemistry / FEBS 2003;270(8):1619-27.
2003: Johannes V Swinnen; Paul P Van Veldhoven; Leen Timmermans; Ellen De Schrijver; Koen Brusselmans; Frank Vanderhoydonc; Tine Van de Sande; Hannelore V Heemers; Walter Heyns; Guido Verhoeven
Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.
Biochemical and biophysical research communications 2003;302(4):898-903.
2003: Veerle Foulon; Minne Casteels; Guy P Mannaerts; Bruce D Gelb; Paul P Van Veldhoven
Thiamine pyrophosphate: an essential cofactor in the mammalian metabolism of 3-methyl-branched fatty acids--implications for thiamine deficiencies?
Advances in experimental medicine and biology 2003;544():305-6.
2003: Myriam Baes; Paul P Van Veldhoven
Lessons from knockout mice. I: Phenotypes of mice with peroxisome biogenesis disorders.
Advances in experimental medicine and biology 2003;544():113-22.
2002: Yi Shan Luo; Jean-Marc Nicaud; Paul P Van Veldhoven; Thierry Chardot
The acyl-CoA oxidases from the yeast Yarrowia lipolytica: characterization of Aox2p.
Archives of biochemistry and biophysics 2002;407(1):32-8.
2002: Veerle Compernolle; Koen Brusselmans; Till Acker; Peter Hoet; Marc Tjwa; Heike Beck; Stephane Plaisance; Yuval Dor; Eli Keshet; Florea Lupu; Benoit Nemery; Mieke Dewerchin; Paul P Van Veldhoven; Karl H Plate; Lieve Moons; Désiré Collen; Peter Carmeliet
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice.
Nature medicine 2002;8(7):702-10.
2002: Karen Ghys; Marc Fransen; Guy P Mannaerts; Paul P Van Veldhoven
Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins.
The Biochemical journal 2002;365(Pt 1):41-50.
2002: Marc Fransen; Chantal Brees; Karen Ghys; Leen Amery; Guy P Mannaerts; Daniel Ladant; Paul P Van Veldhoven
Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay.
Molecular & cellular proteomics : MCP 2002;1(3):243-52.
2002: Sofie Gijsbers; Stanny Asselberghs; Piet Herdewijn; Paul P Van Veldhoven
1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase.
Biochimica et biophysica acta 2002;1580(1):1-8.
2001: Leen Amery; Guy P Mannaerts; Suresh Subramani; Paul P Van Veldhoven; Marc Fransen
Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology.
Combinatorial chemistry & high throughput screening 2001;4(7):545-52.
2001: K De Nys; Els Meyhi; Guy P Mannaerts; Marc Fransen; Paul P Van Veldhoven
Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase.
Biochimica et biophysica acta 2001;1533(1):66-72.
2001: Paul P Van Veldhoven; Els Meyhi; Robert H Squires; Marc Fransen; B Fournier; Vanessa Brys; M J Bennett; Guy P Mannaerts
Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: possible link between racemase deficiency and malabsorption and vitamin K deficiency.
European journal of clinical investigation 2001;31(8):714-22.
2001: Leen Amery; H Sano; Guy P Mannaerts; J Snider; J Van Looy; Marc Fransen; Paul P Van Veldhoven
Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals.
The Biochemical journal 2001;357(Pt 3):635-46.
2001: Marc Fransen; T Wylin; Chantal Brees; Guy P Mannaerts; Paul P Van Veldhoven
Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.
Molecular and cellular biology 2001;21(13):4413-24.
2001: Sofie Gijsbers; Gerd Van der Hoeven; Paul P Van Veldhoven
Subcellular study of sphingoid base phosphorylation in rat tissues: evidence for multiple sphingosine kinases.
Biochimica et biophysica acta 2001;1532(1-2):37-50.
2001: Paul P Van Veldhoven; Minne Casteels; Guy P Mannaerts; Myriam Baes
Further insights into peroxisomal lipid breakdown via alpha- and beta-oxidation.
Biochemical Society transactions 2001;29(Pt 2):292-8.
2001: H Van Houte; E De Hoffmann; Paul P Van Veldhoven; Guy P Mannaerts; Hubert A Carchon; Myriam Baes; Peter E Declercq
Oxidative catabolism of alpha-tocopherol in rat liver microsomes.
Lipids 2001;36(4):367-72.
2001: Steven Huyghe; Minne Casteels; Anneleen Janssen; L Meulders; Guy P Mannaerts; Peter E Declercq; Paul P Van Veldhoven; Myriam Baes
Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse.
The Biochemical journal 2001;353(Pt 3):673-80.
2000: Leen Amery; Marc Fransen; K De Nys; Guy P Mannaerts; Paul P Van Veldhoven
Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans.
Journal of lipid research 2000;41(11):1752-9.
2000: C Causeret; Liesl Geeraert; Gerd Van der Hoeven; Guy P Mannaerts; Paul P Van Veldhoven
Further characterization of rat dihydroceramide desaturase: tissue distribution, subcellular localization, and substrate specificity.
Lipids 2000;35(10):1117-25.
2000: Paul P Van Veldhoven; Sofie Gijsbers; Guy P Mannaerts; J R Vermeesch; Vanessa Brys
Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1).
Biochimica et biophysica acta 2000;1487(2-3):128-34.
2000: Pierre Gressens; Myriam Baes; Philippe Leroux; A Lombet; Paul P Van Veldhoven; Anneleen Janssen; Joseph Vamecq; Stéphane Marret; Philippe Evrard
Neuronal migration disorder in Zellweger mice is secondary to glutamate receptor dysfunction.
Annals of neurology 2000;48(3):336-43.
2000: Paul P Van Veldhoven; Guy P Mannaerts; Peter E Declercq; Myriam Baes
Do sphingoid bases interact with the peroxisome proliferator activated receptor alpha (PPAR-alpha)?
Cellular signalling 2000;12(7):475-9.
2000: Myriam Baes; Steven Huyghe; Peter Carmeliet; Peter E Declercq; Désiré Collen; Guy P Mannaerts; Paul P Van Veldhoven
Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids.
The Journal of biological chemistry 2000;275(21):16329-36.
2000: Vasily D Antonenkov; K Croes; Etienne Waelkens; Paul P Van Veldhoven; Guy P Mannaerts
Identification, purification and characterization of an acetoacetyl-CoA thiolase from rat liver peroxisomes.
European journal of biochemistry / FEBS 2000;267(10):2981-90.
2000: K Croes; Veerle Foulon; Minne Casteels; Paul P Van Veldhoven; Guy P Mannaerts
Phytanoyl-CoA hydroxylase: recognition of 3-methyl-branched acyl-coAs and requirement for GTP or ATP and Mg(2+) in addition to its known hydroxylation cofactors.
Journal of lipid research 2000;41(4):629-36.
2000: Vasily D Antonenkov; Paul P Van Veldhoven; Guy P Mannaerts
Isolation and subunit composition of native sterol carrier protein 2/3-oxoacyl-coenzyme A thiolase from normal rat liver peroxisomes.
Protein expression and purification 2000;18(3):249-56.
2000: Guy P Mannaerts; Paul P Van Veldhoven; Minne Casteels
Peroxisomal lipid degradation via beta- and alpha-oxidation in mammals.
Cell biochemistry and biophysics 2000;32 Spring():73-87.
2000: Anneleen Janssen; Myriam Baes; Pierre Gressens; Guy P Mannaerts; Peter E Declercq; Paul P Van Veldhoven
Docosahexaenoic acid deficit is not a major pathogenic factor in peroxisome-deficient mice.
Laboratory investigation; a journal of technical methods and pathology 2000;80(1):31-5.
2000: Paul P Van Veldhoven
Sphingosine-1-phosphate lyase.
Methods in enzymology 2000;311():244-54.
1999: Veerle Foulon; Vasily D Antonenkov; K Croes; Etienne Waelkens; Guy P Mannaerts; Paul P Van Veldhoven; Minne Casteels
Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10039-44.
1999: Sofie Gijsbers; Guy P Mannaerts; Bernard Himpens; Paul P Van Veldhoven
N-acetyl-sphingenine-1-phosphate is a potent calcium mobilizing agent.
FEBS letters 1999;453(3):269-72.
1999: Marc Fransen; Paul P Van Veldhoven; Suresh Subramani
Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase.
The Biochemical journal 1999;340 ( Pt 2)():561-8.
1999: K Croes; Minne Casteels; M Dieuaide-Noubhani; Guy P Mannaerts; Paul P Van Veldhoven
Stereochemistry of the alpha-oxidation of 3-methyl-branched fatty acids in rat liver.
Journal of lipid research 1999;40(4):601-9.
1999: Vasily D Antonenkov; Paul P Van Veldhoven; Etienne Waelkens; Guy P Mannaerts
Comparison of the stability and substrate specificity of purified peroxisomal 3-oxoacyl-CoA thiolases A and B from rat liver.
Biochimica et biophysica acta 1999;1437(2):136-41.
1999: Vasily D Antonenkov; Paul P Van Veldhoven; Guy P Mannaerts
The commonly used Mg2+-enolate assay can lead to underestimation of thiolase activity.
Analytical biochemistry 1999;267(2):418-20.
1999: Paul P Van Veldhoven; Guy P Mannaerts; Minne Casteels; K Croes
Hepatic alpha-oxidation of phytanic acid. A revised pathway.
Advances in experimental medicine and biology 1999;466():273-81.
1999: Paul P Van Veldhoven; Guy P Mannaerts
Role and organization of peroxisomal beta-oxidation.
Advances in experimental medicine and biology 1999;466():261-72.
1999: K Croes; Paul P Van Veldhoven; Guy P Mannaerts; Minne Casteels
Alpha-oxidation of 3-methyl-branched fatty acids: a revised pathway confined to peroxisomes.
Lipids 1999;34 Suppl():S159.
1999: Vasily D Antonenkov; Paul P Van Veldhoven; Guy P Mannaerts
The growing family of peroxisomal thiolases.
Lipids 1999;34 Suppl():S157.
1999: Sofie Gijsbers; C Causeret; Gerd Van der Hoeven; Paul P Van Veldhoven
Sphingosine kinase: assay conditions, tissue distribution in rat, and subcellular localization in rat kidney and liver.
Lipids 1999;34 Suppl():S77.
1998: T Wylin; Myriam Baes; Chantal Brees; Guy P Mannaerts; Marc Fransen; Paul P Van Veldhoven
Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii.
European journal of biochemistry / FEBS 1998;258(2):332-8.
1998: Leen Amery; Chantal Brees; Myriam Baes; Chiaki Setoyama; Retsu Miura; Guy P Mannaerts; Paul P Van Veldhoven
C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal.
The Biochemical journal 1998;336 ( Pt 2)():367-71.
1998: H Stier; H Dariush Fahimi; Paul P Van Veldhoven; Guy P Mannaerts; Alfred Völkl; Eveline Baumgart
Maturation of peroxisomes in differentiating human hepatoblastoma cells (HepG2): possible involvement of the peroxisome proliferator-activated receptor alpha (PPAR alpha).
Differentiation; research in biological diversity 1998;64(1):55-66.
1998: Paul P Van Veldhoven; Els Meyhi; Guy P Mannaerts
Enzymatic quantitation of cholesterol esters in lipid extracts.
Analytical biochemistry 1998;258(1):152-5.
1998: F Caira; Marie-Claude Clémencet; Mustapha Cherkaoui Malki; M Dieuaide-Noubhani; C Pacot; Paul P Van Veldhoven; Norbert Latruffe
Differential regulation by a peroxisome proliferator of the different multifunctional proteins in guinea pig: cDNA cloning of the guinea pig D-specific multifunctional protein 2.
The Biochemical journal 1998;330 ( Pt 3)():1361-8.
1998: Paul P Van Veldhoven
New insights in peroxisomal beta-oxidation. Implications for human peroxisomal disorders.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1998;60(3):195-214.
1997: M Esquenet; Johannes V Swinnen; Paul P Van Veldhoven; C Denef; Walter Heyns; Guido Verhoeven
Retinoids stimulate lipid synthesis and accumulation in LNCaP prostatic adenocarcinoma cells.
Molecular and cellular endocrinology 1997;136(1):37-46.
1997: Paul P Van Veldhoven; Johannes V Swinnen; M Esquenet; Guido Verhoeven
Lipase-based quantitation of triacylglycerols in cellular lipid extracts: requirement for presence of detergent and prior separation by thin-layer chromatography.
Lipids 1997;32(12):1297-300.
1997: Vasily D Antonenkov; Paul P Van Veldhoven; Etienne Waelkens; Guy P Mannaerts
Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates.
The Journal of biological chemistry 1997;272(41):26023-31.
1997: Liesl Geeraert; Guy P Mannaerts; Paul P Van Veldhoven
Conversion of dihydroceramide into ceramide: involvement of a desaturase.
The Biochemical journal 1997;327 ( Pt 1)():125-32.
1997: Minne Casteels; K Croes; Paul P Van Veldhoven; Guy P Mannaerts
Peroxisomal localization of alpha-oxidation in human liver.
Journal of inherited metabolic disease 1997;20(5):665-73.
1997: Myriam Baes; Pierre Gressens; Eveline Baumgart; Peter Carmeliet; Minne Casteels; Marc Fransen; Philippe Evrard; Dariush Fahimi; Peter E Declercq; Désiré Collen; Paul P Van Veldhoven; Guy P Mannaerts
A mouse model for Zellweger syndrome.
Nature genetics 1997;17(1):49-57.
1997: K Croes; Minne Casteels; Stanny Asselberghs; Piet Herdewijn; Guy P Mannaerts; Paul P Van Veldhoven
Formation of a 2-methyl-branched fatty aldehyde during peroxisomal alpha-oxidation.
FEBS letters 1997;412(3):643-5.
1997: J C Vanhooren; Peter Marynen; Guy P Mannaerts; Paul P Van Veldhoven
Evidence for the existence of a pristanoyl-CoA oxidase gene in man.
The Biochemical journal 1997;325 ( Pt 3)():593-9.
1997: M Dieuaide-Noubhani; Stanny Asselberghs; Guy P Mannaerts; Paul P Van Veldhoven
Evidence that multifunctional protein 2, and not multifunctional protein 1, is involved in the peroxisomal beta-oxidation of pristanic acid.
The Biochemical journal 1997;325 ( Pt 2)():367-73.
1997: H A Van Houte; Paul P Van Veldhoven; Guy P Mannaerts; Myriam Baes; Peter E Declercq
Metabolism of dolichol, dolichoic acid and nordolichoic acid in cultured cells.
Biochimica et biophysica acta 1997;1347(1):93-100.
1997: Paul P Van Veldhoven; K Croes; Minne Casteels; Guy P Mannaerts
2-methylacyl racemase: a coupled assay based on the use of pristanoyl-CoA oxidase/peroxidase and reinvestigation of its subcellular distribution in rat and human liver.
Biochimica et biophysica acta 1997;1347(1):62-8.
1997: D Novikov; M Dieuaide-Noubhani; J R Vermeesch; B Fournier; Guy P Mannaerts; Paul P Van Veldhoven
The human peroxisomal multifunctional protein involved in bile acid synthesis: activity measurement, deficiency in Zellweger syndrome and chromosome mapping.
Biochimica et biophysica acta 1997;1360(3):229-40.
1997: K Croes; Paul P Van Veldhoven; Guy P Mannaerts; Minne Casteels
Production of formyl-CoA during peroxisomal alpha-oxidation of 3-methyl-branched fatty acids.
FEBS letters 1997;407(2):197-200.
1996: K Croes; Minne Casteels; Paul P Van Veldhoven; Guy P Mannaerts
Alpha-oxidation in intact and permeabilized rat hepatocytes.
Annals of the New York Academy of Sciences 1996;804():682-3.
1996: M Dieuaide; D K Novikov; Hubert A Carchon; Paul P Van Veldhoven; Guy P Mannaerts
Substrate stereospecificities of rat liver peroxisomal 3-hydroxyacyl-CoA dehydrogenases.
Annals of the New York Academy of Sciences 1996;804():680-1.
1996: E Baumgart; J C Vanhooren; Marc Fransen; Guy P Mannaerts; Paul P Van Veldhoven
Mammalian peroxisomal acyl-CoA oxidases. III. Molecular characterization of human branched chain fatty acyl-CoA oxidase.
Annals of the New York Academy of Sciences 1996;804():678-9.
1996: E Baumgart; J C Vanhooren; Marc Fransen; Paul P Van Veldhoven; Guy P Mannaerts
Mammalian peroxisomal acyl-CoA oxidases. II. Molecular characterization of rat trihydroxycoprostanoyl-CoA oxidase.
Annals of the New York Academy of Sciences 1996;804():676-7.
1996: J C Vanhooren; E Baumgart; Marc Fransen; Guy P Mannaerts; Paul P Van Veldhoven
Mammalian peroxisomal acyl-CoA oxidases. I. Molecular characterization of rat pristanoyl-CoA oxidase.
Annals of the New York Academy of Sciences 1996;804():674-5.
1996: Marc Fransen; Peter Marynen; E Baumgart; J C Vanhooren; Guy P Mannaerts; Paul P Van Veldhoven
Further characterization of the human peroxisomal C-terminal targeting signal protein import receptor.
Annals of the New York Academy of Sciences 1996;804():672-3.
1996: Guy P Mannaerts; Paul P Van Veldhoven
Functions and organization of peroxisomal beta-oxidation.
Annals of the New York Academy of Sciences 1996;804():99-115.
1996: E Baumgart; J C Vanhooren; Marc Fransen; Peter Marynen; M Puype; J Vandekerckhove; Jack Leunissen; H D Fahimi; Guy P Mannaerts; Paul P Van Veldhoven
Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13748-53.
1996: E Baumgart; J C Vanhooren; Marc Fransen; Fred Van Leuven; H D Fahimi; Paul P Van Veldhoven; Guy P Mannaerts
Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase.
The Biochemical journal 1996;320 ( Pt 1)():115-21.
1996: Marc Fransen; Chantal Brees; Paul P Van Veldhoven; Guy P Mannaerts
The visualization of peroxisomal proteins containing a C-terminal targeting sequence on western blot by using the biotinylated PTS1-receptor.
Analytical biochemistry 1996;242(1):26-30.
1996: Paul P Van Veldhoven; Stanny Asselberghs; H J Eyssen; Guy P Mannaerts
Stabilisation and partial purification of Triton X-100 solubilised trihydroxycoprostanoyl-CoA synthetase from rat liver.
Biochemistry and molecular biology international 1996;40(3):447-57.
1996: Johannes V Swinnen; Paul P Van Veldhoven; M Esquenet; Walter Heyns; Guido Verhoeven
Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP.
Endocrinology 1996;137(10):4468-74.
1996: K Croes; Minne Casteels; E De Hoffmann; Guy P Mannaerts; Paul P Van Veldhoven
alpha-Oxidation of 3-methyl-substituted fatty acids in rat liver. Production of formic acid instead of CO2, cofactor requirements, subcellular localization and formation of a 2-hydroxy-3-methylacyl-CoA intermediate.
European journal of biochemistry / FEBS 1996;240(3):674-83.
1996: M Dieuaide-Noubhani; D Novikov; E Baumgart; J C Vanhooren; Marc Fransen; M Goethals; J Vandekerckhove; Paul P Van Veldhoven; Guy P Mannaerts
Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver. Relationship between the different dehydrogenases and evidence that fatty acids and the C27 bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins.
European journal of biochemistry / FEBS 1996;240(3):660-6.
1996: J C Vanhooren; Marc Fransen; B de Béthune; E Baumgart; Myriam Baes; S Torrekens; Fred Van Leuven; Guy P Mannaerts; Paul P Van Veldhoven
Rat pristanoyl-CoA oxidase. cDNA cloning and recognition of its C-terminal (SQL) by the peroxisomal-targeting signal 1 receptor.
European journal of biochemistry / FEBS 1996;239(2):302-9.
1996: Paul P Van Veldhoven; K Croes; Stanny Asselberghs; P Herdewijn; Guy P Mannaerts
Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase.
FEBS letters 1996;388(1):80-4.
1996: Paul P Van Veldhoven; E Baumgart; Guy P Mannaerts
Iodixanol (Optiprep), an improved density gradient medium for the iso-osmotic isolation of rat liver peroxisomes.
Analytical biochemistry 1996;237(1):17-23.
1995: Peter Marynen; Marc Fransen; Petra Raeymaekers; Guy P Mannaerts; Paul P Van Veldhoven
The gene for the peroxisomal targeting signal import receptor (PXR1) is located on human chromosome 12p13, flanked by TPI1 and D12S1089.
Genomics 1995;30(2):366-8.
1995: P De Ceuster; Guy P Mannaerts; Paul P Van Veldhoven
Identification and subcellular localization of sphinganine-phosphatases in rat liver.
The Biochemical journal 1995;311 ( Pt 1)():139-46.
1995: Paul P Van Veldhoven; W R Bishop; D A Yurivich; R M Bell
Ceramide quantitation: evaluation of a mixed micellar assay using E. coli diacylglycerol kinase.
Biochemistry and molecular biology international 1995;36(1):21-30.
1995: Marc Fransen; Chantal Brees; E Baumgart; J C Vanhooren; Myriam Baes; Guy P Mannaerts; Paul P Van Veldhoven
Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor.
The Journal of biological chemistry 1995;270(13):7731-6.
1995: K Croes; Minne Casteels; Paul P Van Veldhoven; Guy P Mannaerts
Evidence for the importance of iron in the alpha-oxidation of 3-methyl-substituted fatty acids in the intact cell.
Biochimica et biophysica acta 1995;1255(1):63-7.
1995: Paul P Van Veldhoven
Activity measurements of acyl-CoA oxidases in human liver.
Journal of inherited metabolic disease 1995;18 Suppl 1():125-34.
1994: Minne Casteels; K Croes; Paul P Van Veldhoven; Guy P Mannaerts
Aminotriazole is a potent inhibitor of alpha-oxidation of 3-methyl-substituted fatty acids in rat liver.
Biochemical pharmacology 1994;48(10):1973-5.
1994: Paul P Van Veldhoven; P Van Rompuy; J C Vanhooren; Guy P Mannaerts
Purification and further characterization of peroxisomal trihydroxycoprostanoyl-CoA oxidase from rat liver.
The Biochemical journal 1994;304 ( Pt 1)():195-200.
1994: Marc Fransen; Chantal Brees; B de Béthune; Paul P Van Veldhoven; Guy P Mannaerts
The 80 kDa cytosolic protein that binds the C-terminal part of rat acyl-CoA oxidase is not a peroxisomal import receptor but a prolyl-endopeptidase.
Biochimica et biophysica acta 1994;1201(2):157-64.
1994: D K Novikov; G F Vanhove; Hubert A Carchon; Stanny Asselberghs; H J Eyssen; Paul P Van Veldhoven; Guy P Mannaerts
Peroxisomal beta-oxidation. Purification of four novel 3-hydroxyacyl-CoA dehydrogenases from rat liver peroxisomes.
The Journal of biological chemistry 1994;269(43):27125-35.
1994: S Huang; Paul P Van Veldhoven; Stanny Asselberghs; H J Eyssen; E de Hoffmann; Guy P Mannaerts
Comparison of fatty acid alpha-oxidation by rat hepatocytes and by liver microsomes fortified with NADPH, Fe3+ and phosphate.
Lipids 1994;29(10):671-8.
1994: J C Vanhooren; Stanny Asselberghs; H J Eyssen; Guy P Mannaerts; Paul P Van Veldhoven
Activation of 3-methyl-branched fatty acids in rat liver.
The International journal of biochemistry 1994;26(9):1095-101.
1994: Paul P Van Veldhoven; P De Ceuster; R Rozenberg; Guy P Mannaerts; E de Hoffmann
On the presence of phosphorylated sphingoid bases in rat tissues. A mass-spectrometric approach.
FEBS letters 1994;350(1):91-5.
1994: Paul P Van Veldhoven; P Van Rompuy; Marc Fransen; B De Béthune; Guy P Mannaerts
Large-scale purification and further characterization of rat pristanoyl-CoA oxidase.
European journal of biochemistry / FEBS 1994;222(3):795-801.
1994: Paul P Van Veldhoven; Guy P Mannaerts
Assembly of the peroxisomal membrane.
Sub-cellular biochemistry 1994;22():231-61.
1993: G Vanhove; Paul P Van Veldhoven; H J Eyssen; Guy P Mannaerts
Mitochondrial short-chain acyl-CoA dehydrogenase of human liver and kidney can function as an oxidase.
The Biochemical journal 1993;292 ( Pt 1)():23-30.
1993: G F Vanhove; Paul P Van Veldhoven; Marc Fransen; S Denis; H J Eyssen; R J Wanders; Guy P Mannaerts
The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney.
The Journal of biological chemistry 1993;268(14):10335-44.
1993: Guy P Mannaerts; Paul P Van Veldhoven
Metabolic pathways in mammalian peroxisomes.
Biochimie 1993;75(3-4):147-58.
1993: Guy P Mannaerts; Paul P Van Veldhoven
[Peroxisomal beta-oxidation].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1993;55(1):45-78.
1992: Paul P Van Veldhoven; G Vanhove; S Assselberghs; H J Eyssen; Guy P Mannaerts
Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase.
The Journal of biological chemistry 1992;267(28):20065-74.
1992: Guy P Mannaerts; Paul P Van Veldhoven
Role of peroxisomes in mammalian metabolism.
Cell biochemistry and function 1992;10(3):141-51.
1992: K Verheyden; Marc Fransen; Paul P Van Veldhoven; Guy P Mannaerts
Presence of small GTP-binding proteins in the peroxisomal membrane.
Biochimica et biophysica acta 1992;1109(1):48-54.
1992: S Huang; Paul P Van Veldhoven; F Vanhoutte; G Parmentier; H J Eyssen; Guy P Mannaerts
Alpha-oxidation of 3-methyl-substituted fatty acids in rat liver.
Archives of biochemistry and biophysics 1992;296(1):214-23.
1991: G Vanhove; Paul P Van Veldhoven; F Vanhoutte; G Parmentier; H J Eyssen; Guy P Mannaerts
Mitochondrial and peroxisomal beta oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver.
The Journal of biological chemistry 1991;266(36):24670-5.
1991: Paul P Van Veldhoven; G Vanhove; F Vanhoutte; G Dacremont; G Parmentier; H J Eyssen; Guy P Mannaerts
Identification and purification of a peroxisomal branched chain fatty acyl-CoA oxidase.
The Journal of biological chemistry 1991;266(36):24676-83.
1991: Paul P Van Veldhoven; Chantal Brees; Guy P Mannaerts
D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man.
Biochimica et biophysica acta 1991;1073(1):203-8.
1990: Minne Casteels; L Schepers; Paul P Van Veldhoven; H J Eyssen; Guy P Mannaerts
Separate peroxisomal oxidases for fatty acyl-CoAs and trihydroxycoprostanoyl-CoA in human liver.
Journal of lipid research 1990;31(10):1865-72.
1990: Minne Casteels; L Schepers; Paul P Van Veldhoven; Guy P Mannaerts
Separate peroxisomal acyl-CoA oxidases for fatty acids and trihydroxycoprostanic acid in human liver.
Biochemical Society transactions 1990;18(5):1003-4.
1990: L Schepers; Paul P Van Veldhoven; Minne Casteels; H J Eyssen; Guy P Mannaerts
Presence of three acyl-CoA oxidases in rat liver peroxisomes. An inducible fatty acyl-CoA oxidase, a noninducible fatty acyl-CoA oxidase, and a noninducible trihydroxycoprostanoyl-CoA oxidase.
The Journal of biological chemistry 1990;265(9):5242-6.
1990: Guy P Mannaerts; Paul P Van Veldhoven
The peroxisome: functional properties in health and disease.
Biochemical Society transactions 1990;18(1):87-9.
1989: L Schepers; Paul P Van Veldhoven; H J Eyssen; Guy P Mannaerts
Separate peroxisomal oxidases for long-chain acyl-CoA and trihydroxycoprostanoyl-CoA.
Biochemical Society transactions 1989;17(6):1076.
1989: M Lemmens; K Verheyden; Paul P Van Veldhoven; J Vereecke; Guy P Mannaerts; Edward Carmeliet
Single-channel analysis of a large conductance channel in peroxisomes from rat liver.
Biochimica et biophysica acta 1989;984(3):351-9.
1988: L Schepers; Minne Casteels; Joseph Vamecq; G Parmentier; Paul P Van Veldhoven; Guy P Mannaerts
Beta-oxidation of the carboxyl side chain of prostaglandin E2 in rat liver peroxisomes and mitochondria.
The Journal of biological chemistry 1988;263(6):2724-31.
1988: F D Suyatna; Paul P Van Veldhoven; Marcel Borgers; Guy P Mannaerts
Phospholipid composition and amphiphile content of isolated sarcolemma from normal and autolytic rat myocardium.
Journal of molecular and cellular cardiology 1988;20(1):47-62.