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Wesley Van Voorhis

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Loren Baugh; Darren W Begley; Garry W Buchko; Ryan Choi; Matthew C Clifton; Shellie H Dieterich; David M Dranow; Thomas E Edwards; James W Fairman; David Fox; Larry A Gallagher; Anna S Gardberg; Angela Gillespie; Colin Manoil; Peter J Myler; Steve Nakazawa-Hewitt; Alberto Napuli; Mary Trang Nguyen; Rapatbhorn Patrapuvich; Isabelle Phan; Robin Stacy; Bart L Staker; Lance J Stewart; Jan Abendroth; Brianna Armour; Lynn Barrett; Wesley C Van Voorhis
Combining functional and structural genomics to sample the essential Burkholderia structome.
Eric T Larson; Frederick S Buckner; Erkang Fan; Wim G J Hol; Jessica E Kim; Alberto J Napuli; Wesley C Van Voorhis; Christophe L M J Verlinde; Frank H Zucker; Ethan A Merritt
Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Zhongsheng Zhang; Alejandro Castellanos-Gonzalez; Jennifer A Geiger; Penqing He; Steven M Johnson; Eric T Larson; Dustin J Maly; Ethan A Merritt; Kayode K Ojo; Marilyn Parsons; Wesley C Van Voorhis; Christophe L M J Verlinde; A Clinton White; Erkang Fan
Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.

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All Publications

2013: Loren Baugh; Darren W Begley; Garry W Buchko; Ryan Choi; Matthew C Clifton; Shellie H Dieterich; David M Dranow; Thomas E Edwards; James W Fairman; David Fox; Larry A Gallagher; Anna S Gardberg; Angela Gillespie; Colin Manoil; Peter J Myler; Steve Nakazawa-Hewitt; Alberto Napuli; Mary Trang Nguyen; Rapatbhorn Patrapuvich; Isabelle Phan; Robin Stacy; Bart L Staker; Lance J Stewart; Jan Abendroth; Brianna Armour; Lynn Barrett; Wesley C Van Voorhis
Combining functional and structural genomics to sample the essential Burkholderia structome.
PloS one 2013;8(1):e53851.
2012: Eric T Larson; Frederick S Buckner; Erkang Fan; Wim G J Hol; Jessica E Kim; Alberto J Napuli; Wesley C Van Voorhis; Christophe L M J Verlinde; Frank H Zucker; Ethan A Merritt
Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Acta crystallographica. Section D, Biological crystallography 2012;68(Pt 9):1194-200.
2012: Zhongsheng Zhang; Alejandro Castellanos-Gonzalez; Jennifer A Geiger; Penqing He; Steven M Johnson; Eric T Larson; Dustin J Maly; Ethan A Merritt; Kayode K Ojo; Marilyn Parsons; Wesley C Van Voorhis; Christophe L M J Verlinde; A Clinton White; Erkang Fan
Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.
Bioorganic & medicinal chemistry letters 2012;22(16):5264-7.
2012: Kayode K Ojo; Claudia Pfander; Molly C Reid; Christophe L M J Verlinde; Oliver Billker; Cassie M Bryan; Charlotte Burstroem; Anna M W Fox; Stephen N Hewitt; Steven M Johnson; Stefan Kappe; Mark Kennedy; Eric T Larson; David J Leibly; Dustin J Maly; Henning Mann; Ethan A Merritt; Natascha R Mueller; Ryan C Murphy; Wesley C Van Voorhis
Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors.
The Journal of clinical investigation 2012;122(6):2301-5.
2012: Gregory J Crowther; S Arshiya Quadri; Benjamin J Shannon-Alferes; Wesley C Van Voorhis; Henry Rosen
A mechanism-based whole-cell screening assay to identify inhibitors of protein export in Escherichia coli by the Sec pathway.
Journal of biomolecular screening 2012;17(4):535-41.
2012: Eric T Larson; David J Leibly; Dustin J Maly; Ryan C Murphy; Kayode K Ojo; B Gayani K Perera; Molly C Reid; Wesley C Van Voorhis; Christophe L M J Verlinde; Zhongsheng Zhang; Edward J Dale; Erkang Fan; Anna M W Fox; Stephen N Hewitt; Wim G J Hol; Steven M Johnson; Jae Kim; Jessica E Kim; Ethan A Merritt
Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
Journal of medicinal chemistry 2012;55(6):2803-10.
2012: Steven M Johnson; Eric T Larson; Edward J Dale; Amy E DeRocher; Erkang Fan; Anna M W Fox; Jennifer A Geiger; Panqing He; Ethan A Merritt; Natascha R Mueller; Ryan C Murphy; Kayode K Ojo; Marilyn Parsons; B Gayani K Perera; Molly C Reid; Wesley C Van Voorhis; Zhongsheng Zhang; Dustin J Maly
Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.
Journal of medicinal chemistry 2012;55(5):2416-26.
2012: David J Leibly; Trang Nhu Nguyen; Lynn K Barrett; Stephen N Hewitt; Louis T Kao; Wesley C Van Voorhis
Stabilizing additives added during cell lysis aid in the solubilization of recombinant proteins.
PloS one 2012;7(12):e52482.
2011: Solomon Nwaka; Jean-Marc Paris; Bernadette Ramirez; Robert Ridley; Moses Samje; Simon Townson; Wesley C Van Voorhis; Clive Yeates; Fouad Yousif; Dominique Besson; Quentin Bickle; Fidelis Cho-Ngwa; Foluke Fakorede; Suzanne Gokool; Louis Maes; Nuha R Mansour; An Matheeussen; Shailja Misra-Bhattacharya; P K Murthy; Timothy Geary
Integrated dataset of screening hits against multiple neglected disease pathogens.
PLoS neglected tropical diseases 2011;5(12):e1412.
2011: Susan P Yates; Jimin Zheng; Cassie M Bryan; Thomas E Edwards; Peter J Myler; Adam J Stein; Lance J Stewart; Wesley C Van Voorhis; Zongchao Jia
Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase.
Biochemistry 2011;50(38):8103-6.
2011: Matthew C Clifton; Shellie H Dieterich; Thomas E Edwards; Ilyssa Exley; Micah Ferrell; Angela K Gillespie; David J Leibly; Peter J Myler; Bart L Staker; Jan Abendroth; Wesley C Van Voorhis; Lance J Stewart
Structure of the cystathionine γ-synthase MetB from Mycobacterium ulcerans.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1154-8.
2011: Garry W Buchko; Stephen N Hewitt; Alberto J Napuli; Wesley C Van Voorhis; Peter J Myler
Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1148-53.
2011: Thomas Leeper; Peter J Myler; Wesley C Van Voorhis; Suxin Zhang; Gabriele Varani
Comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1141-7.
2011: Ravi P Barnwal; Wesley C Van Voorhis; Gabriele Varani
NMR structure of an acyl-carrier protein from Borrelia burgdorferi.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1137-40.
2011: Garry W Buchko; Stephen N Hewitt; Alberto J Napuli; Wesley C Van Voorhis; Peter J Myler
Solution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis, the etiological agent responsible for brucellosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1129-36.
2011: Isabelle Phan; Lance J Stewart; Sandhya Subramanian; Wesley C Van Voorhis; Yang Zhang; Thomas E Edwards; Wenjin Guo; Christian Olsen; Peter J Myler
Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1123-8.
2011: Sandhya Subramanian; Wesley C Van Voorhis; Jan Abendroth; A Napuli; Christian Olsen; Isabelle Q H Phan; Robin Stacy; Bart L Staker; Peter J Myler
Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1118-22.
2011: M Ferrell; J Abendroth; T E Edwards; B Sankaran; Bart L Staker; L J Stewart; Wesley C Van Voorhis; Y Zhang; P J Myler
Structure of aldose reductase from Giardia lamblia.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1113-7.
2011: Jan Abendroth; Janhavi Bhandari; Shellie Dieterich; Thomas E Edwards; Anna S Gardberg; Peter J Myler; Alberto J Napuli; Banumathi Sankaran; Bart L Staker; Wesley C Van Voorhis; Lance J Stewart
BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a 'putative β-lactamase-like protein' from Brucella melitensis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1106-12.
2011: Trang N Nguyen; Lance Stewart; Jan Abendroth; Wenjin Guo; Angela Kelley; Kristen P Le; David J Leibly; Peter J Myler; Wesley C Van Voorhis
Structure of triosephosphate isomerase from Cryptosporidium parvum.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1095-9.
2011: David J Leibly; Banumathi Sankaran; Lance Stewart; Jan Abendroth; Lynn K Barrett; Cassie M Bryan; Angela Kelley; Wesley C Van Voorhis
Structure of thymidylate kinase from Ehrlichia chaffeensis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1090-4.
2011: David J Leibly; Paul A Newling; Lance J Stewart; Jan Abendroth; Wenjin Guo; Angela Kelley; Wesley C Van Voorhis
Structure of a cyclin-dependent kinase from Giardia lamblia.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1084-9.
2011: Garry W Buchko; Thomas E Edwards; Stephen N Hewitt; Laura Law; Alberto J Napuli; Bart L Staker; Lance J Stewart; Wesley C Van Voorhis; Jan Abendroth; Tracy L Arakaki; Peter J Myler
Structure of a Nudix hydrolase (MutT) in the Mg(2+)-bound state from Bartonella henselae, the bacterium responsible for cat scratch fever.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1078-83.
2011: Darren W Begley; Douglas R Davies; Robert C Hartley; Stephen N Hewitt; Peter J Myler; Amanda L Rychel; Bart L Staker; Wesley C Van Voorhis; Lance J Stewart
Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1060-9.
2011: Thomas E Edwards; David J Leibly; Peter J Myler; Banumathi Sankaran; Dhileep Sivam; Bart L Staker; Jan Abendroth; Cassie M Bryan; Shellie H Dieterich; Wesley C Van Voorhis; Lance J Stewart
Structures of a putative ζ-class glutathione S-transferase from the pathogenic fungus Coccidioides immitis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1038-43.
2011: Thomas E Edwards; David J Leibly; Peter J Myler; Isabelle Phan; Bart L Staker; Jacob B Statnekov; Jan Abendroth; Janhavi Bhandari; Shellie H Dieterich; Wesley C Van Voorhis; Lance J Stewart
Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1032-7.
2011: Cassie M Bryan; Ryan Choi; Thomas E Edwards; Angela Kelley; David J Leibly; Alberto J Napuli; Janhavi Bhandari; Wesley C Van Voorhis; Lance J Stewart
High-throughput protein production and purification at the Seattle Structural Genomics Center for Infectious Disease.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1010-4.
2011: Stephen N Hewitt; Angela Kelley; Alberto J Napuli; Ryan Choi; Gregory J Crowther; Wesley C Van Voorhis
Expression of proteins in Escherichia coli as fusions with maltose-binding protein to rescue non-expressed targets in a high-throughput protein-expression and purification pipeline.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):1006-9.
2011: Ryan Choi; Angela Kelley; David Leibly; Alberto Napuli; Stephen Nakazawa Hewitt; Wesley C Van Voorhis
Immobilized metal-affinity chromatography protein-recovery screening is predictive of crystallographic structure success.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):998-1005.
2011: Robin Stacy; Bart L Staker; Lance J Stewart; Wesley C Van Voorhis; Gabriele Varani; Darren W Begley; Garry W Buchko; Isabelle Phan; Peter J Myler
Structural genomics of infectious disease drug targets: the SSGCID.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 9):979-84.
2011: Sayaka Shibata; Wesley C Van Voorhis; Christophe L M J Verlinde; Zhongsheng Zhang; Frank H Zucker; Wim G J Hol; Angela M Kelley; Konstantin Korotkov; Ethan A Merritt; Natasha Mueller; Alberto Napuli; Jennifer Ross; Frederick S Buckner; Jaclyn Delarosa; Erkang Fan
Screening a fragment cocktail library using ultrafiltration.
Analytical and bioanalytical chemistry 2011;401(5):1585-91.
2011: Eric T Larson; Jessica E Kim; Lisa J Castaneda; Alberto J Napuli; Zhongsheng Zhang; Erkang Fan; Frank H Zucker; Christophe L M J Verlinde; Frederick S Buckner; Wesley C Van Voorhis; Wim G J Hol; Ethan A Merritt
The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer.
Journal of molecular biology 2011;409(2):159-76.
2011: Sayaka Shibata; John R Gillespie; Angela M Kelley; Alberto J Napuli; Zhongsheng Zhang; Kuzma V Kovzun; Ranae M Pefley; Jocelyn Lam; Frank H Zucker; Wesley C Van Voorhis; Ethan A Merritt; Wim G J Hol; Christophe L M J Verlinde; Erkang Fan; Frederick S Buckner
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.
Antimicrobial agents and chemotherapy 2011;55(5):1982-9.
2011: Ethan A Merritt; Tracy L Arakaki; Robert Gillespie; Alberto J Napuli; Jessica E Kim; Frederick S Buckner; Wesley C Van Voorhis; Christophe L M J Verlinde; Erkang Fan; Frank Zucker; Wim G J Hol
Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase.
Molecular and biochemical parasitology 2011;177(1):20-8.
2011: Kayode K Ojo; Tracy L Arakaki; Alberto J Napuli; Krishna K Inampudi; Katelyn R Keyloun; Li Zhang; Wim G J Hol; Christophe L M J Verlinde; Ethan A Merritt; Wesley C Van Voorhis
Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3.
Molecular and biochemical parasitology 2011;176(2):98-108.
2011: Eric T Larson; Jessica E Kim; Frank H Zucker; Angela Kelley; Natascha Mueller; Alberto J Napuli; Christophe L M J Verlinde; Erkang Fan; Frederick S Buckner; Wesley C Van Voorhis; Ethan A Merritt; Wim G J Hol
Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate.
Biochimie 2011;93(3):570-82.
2011: Erin J Engelson; Frederick S Buckner; Wesley C Van Voorhis
An essential farnesylated kinesin in Trypanosoma brucei.
PloS one 2011;6(11):e26508.
2011: Thomas E Edwards; Anna S Gardberg; David J Leibly; Jess T Leonard; Peter J Myler; Eric R Smith; Bart L Staker; Ariel B Abramov; Ruth O Baydo; Matthew C Clifton; Kaitlin B Thompkins; Wesley C Van Voorhis; Lance J Stewart
Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis.
BMC structural biology 2011;11():39.
2011: Richard O Oduor; Kayode K Ojo; Gareth P Williams; Francois Bertelli; James Mills; Louis Maes; David C Pryde; Tanya Parkinson; Wesley C Van Voorhis; Tod P Holler
Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads.
PLoS neglected tropical diseases 2011;5(4):e1017.
2011: Darren W Begley; Douglas R Davies; Robert C Hartley; Thomas E Edwards; Bart L Staker; Wesley C Van Voorhis; Peter J Myler; Lance J Stewart
Fragment screening of infectious disease targets in a structural genomics environment.
Methods in enzymology 2011;493():533-56.
2011: Gregory J Crowther; Alberto J Napuli; James H Gilligan; Kerstin Gagaring; Rachel Borboa; Carolyn Francek; Zhong Chen; Eleanor F Dagostino; Justin B Stockmyer; Yu Wang; Philip P Rodenbough; Lisa J Castaneda; David J Leibly; Janhavi Bhandari; Michael H Gelb; Achim Brinker; Ingo H Engels; Jennifer Taylor; Arnab K Chatterjee; Pascal Fantauzzi; Richard J Glynne; Wesley C Van Voorhis; Kelli L Kuhen
Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.
Molecular and biochemical parasitology 2011;175(1):21-9.
2010: Stephen Fletcher; Erin Pusateri Keaney; Christopher G Cummings; Michelle A Blaskovich; Michael A Hast; Matthew Glenn; Sung-Youn Chang; Cynthia J Bucher; Ryan J Floyd; William P Katt; Michael H Gelb; Wesley C Van Voorhis; Lorena S Beese; Said M Sebti; Andrew D Hamilton
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
Journal of medicinal chemistry 2010;53(19):6867-88.
2010: Tracy L Arakaki; Megan Carter; Alberto J Napuli; Christophe L M J Verlinde; Erkang Fan; Frank Zucker; Frederick S Buckner; Wesley C Van Voorhis; Wim G J Hol; Ethan A Merritt
The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs.
Journal of structural biology 2010;171(2):238-43.
2010: Frank H Zucker; Jaclyn dela Rosa; Tracy L Arakaki; Frederick S Buckner; Lisa J Castaneda; Erkang Fan; Jessica Kim; Eric T Larson; Ethan A Merritt; Natascha Mueller; Stephen R Nakazawa Hewitt; Alberto J Napuli; Jenni Ross; Christine Stewart; Easwara Subramanian; Wesley C Van Voorhis; Christophe L M J Verlinde; Liren Xiao; Li Zhang; Wim G J Hol
Prediction of protein crystallization outcome using a hybrid method.
Journal of structural biology 2010;171(1):64-73.
2010: Kayode K Ojo; Eric T Larson; Katelyn R Keyloun; Lisa J Castaneda; Amy E Derocher; Krishna K Inampudi; Jessica E Kim; Tracy L Arakaki; Ryan C Murphy; Li Zhang; Alberto J Napuli; Dustin J Maly; Christophe Verlinde; Frederick S Buckner; Marilyn Parsons; Wim G J Hol; Ethan A Merritt; Wesley C Van Voorhis
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.
Nature structural & molecular biology 2010;17(5):602-7.
2010: Gregory J Crowther; Panqing He; Philip P Rodenbough; Andrew P Thomas; Kuzma V Kovzun; David J Leibly; Janhavi Bhandari; Lisa J Castaneda; Wim G J Hol; Michael H Gelb; Alberto J Napuli; Wesley C Van Voorhis
Use of thermal melt curves to assess the quality of enzyme preparations.
Analytical biochemistry 2010;399(2):268-75.
2010: Audrey R Odom; Wesley C Van Voorhis
Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene.
Molecular and biochemical parasitology 2010;170(2):108-11.
2010: Ethan A Merritt; Tracy L Arakaki; John R Gillespie; Eric T Larson; Angela Kelley; Natascha Mueller; Alberto J Napuli; Jessica Kim; Li Zhang; Christophe Verlinde; Erkang Fan; Frank Zucker; Frederick S Buckner; Wesley C Van Voorhis; Wim G J Hol
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
Journal of molecular biology 2010;397(2):481-94.
2010: Eric T Larson; Devaraja G Mudeppa; John R Gillespie; Natascha Mueller; Alberto J Napuli; Jennifer A Arif; Jenni Ross; Tracy L Arakaki; Angela Lauricella; George deTitta; Joseph Luft; Frank Zucker; Christophe Verlinde; Erkang Fan; Wesley C Van Voorhis; Frederick S Buckner; Pradipsinh K Rathod; Wim G J Hol; Ethan A Merritt
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
Journal of molecular biology 2010;396(5):1244-59.
2010: Ethan A Merritt; Tracy L Arakaki; Eric T Larson; Angela Kelley; Natascha Mueller; Alberto J Napuli; Li Zhang; George Deditta; Joseph Luft; Christophe Verlinde; Erkang Fan; Frank Zucker; Frederick S Buckner; Wesley C Van Voorhis; Wim G J Hol
Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.
Molecular and biochemical parasitology 2010;169(2):95-100.
2010: Thomas E Edwards; Isabelle Phan; Jan Abendroth; Shellie H Dieterich; Amir Masoudi; Wenjin Guo; Stephen N Hewitt; Angela Kelley; David Leibly; Mitch J Brittnacher; Bart L Staker; Samuel I Miller; Wesley C Van Voorhis; Peter J Myler; Lance J Stewart
Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head.
PloS one 2010;5(9):.
2010: Gregory J Crowther; Dhanasekaran Shanmugam; Santiago J Carmona; Maria A Doyle; Christiane Hertz-Fowler; Matthew Berriman; Solomon Nwaka; Stuart A Ralph; David S Roos; Wesley C Van Voorhis; Fernán Agüero
Identification of attractive drug targets in neglected-disease pathogens using an in silico approach.
PLoS neglected tropical diseases 2010;4(8):e804.
2009: Garry W Buchko; Stephen N Hewitt; Alberto J Napuli; Wesley C Van Voorhis; Peter J Myler
Backbone and side chain (1)H, (13)C, and (15)N NMR assignments for the organic hydroperoxide resistance protein (Ohr) from Burkholderia pseudomallei.
Biomolecular NMR assignments 2009;3(2):163-6.
2009: Wesley C Van Voorhis; Wim G J Hol; Peter J Myler; Lance J Stewart
The role of medical structural genomics in discovering new drugs for infectious diseases.
PLoS computational biology 2009;5(10):e1000530.
2009: Gregory J Crowther; Alberto J Napuli; Andrew P Thomas; Diana J Chung; Kuzma V Kovzun; David J Leibly; Lisa J Castaneda; Janhavi Bhandari; Christopher J Damman; Raymond Hui; Wim G J Hol; Frederick S Buckner; Christophe Verlinde; Zhongsheng Zhang; Erkang Fan; Wesley C Van Voorhis
Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands.
Journal of biomolecular screening 2009;14(6):700-7.
2009: Praveen Kumar Suryadevara; Srinivas Olepu; Jeffrey W Lockman; Junko Ohkanda; Mandana Karimi; Christophe Verlinde; James M Kraus; Jan Schoepe; Wesley C Van Voorhis; Andrew D Hamilton; Frederick S Buckner; Michael H Gelb
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.
Journal of medicinal chemistry 2009;52(12):3703-15.
2009: Michael A Hast; Stephen Fletcher; Christopher G Cummings; Erin E Pusateri; Michelle A Blaskovich; Kasey Rivas; Michael H Gelb; Wesley C Van Voorhis; Said M Sebti; Andrew D Hamilton; Lorena S Beese
Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.
Chemistry & biology 2009;16(2):181-92.
2009: Christophe L M J Verlinde; Erkang Fan; Sayaka Shibata; Zongsheng Zhang; Zhihua Sun; Wei Deng; Jennifer Ross; Jessica Kim; Liren Xiao; Tracy L Arakaki; Jürgen Bosch; Jonathan M Caruthers; Eric T Larson; Isolde Letrong; Alberto Napuli; Angela Kelly; Natasha Mueller; Frank Zucker; Wesley C Van Voorhis; Frederick S Buckner; Ethan A Merritt; Wim G J Hol
Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium.
Current topics in medicinal chemistry 2009;9(18):1678-87.
2008: Fernán Agüero; Bissan Al-Lazikani; Martin Aslett; Matthew Berriman; Frederick S Buckner; Robert K Campbell; Santiago Carmona; Ian M Carruthers; A W Edith Chan; Feng Chen; Gregory J Crowther; Maria A Doyle; Christiane Hertz-Fowler; Andrew L Hopkins; Gregg McAllister; Solomon Nwaka; John Overington; Arnab Pain; Gaia V Paolini; Ursula Pieper; Stuart A Ralph; Aaron Riechers; David S Roos; Andrej Sali; Dhanasekaran Shanmugam; Takashi Suzuki; Wesley C Van Voorhis; Christophe Verlinde
Genomic-scale prioritization of drug targets: the TDR Targets database.
Nature reviews. Drug discovery 2008;7(11):900-7.
2008: Kayode K Ojo; John R Gillespie; Aaron J Riechers; Alberto J Napuli; Christophe Verlinde; Frederick S Buckner; Michael H Gelb; Mathias M Domostoj; Susan J Wells; Alexander Scheer; Timothy Wells; Wesley C Van Voorhis
Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.
Antimicrobial agents and chemotherapy 2008;52(10):3710-7.
2008: Eric T Larson; Wei Deng; Brian Krumm; Alberto Napuli; Natascha Mueller; Wesley C Van Voorhis; Frederick S Buckner; Erkang Fan; Angela Lauricella; George deTitta; Joseph Luft; Frank Zucker; Wim G J Hol; Christophe Verlinde; Ethan A Merritt
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
Journal of molecular biology 2008;381(4):975-88.
2008: Stephen Fletcher; Christopher G Cummings; Kasey Rivas; William P Katt; Carrie Hornéy; Frederick S Buckner; Debopam Chakrabarti; Said M Sebti; Michael H Gelb; Wesley C Van Voorhis; Andrew D Hamilton
Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.
Journal of medicinal chemistry 2008;51(17):5176-97.
2008: Ethan A Merritt; Margaret Holmes; Frederick S Buckner; Wesley C Van Voorhis; Erin Quartly; Eric M Phizicky; Angela Lauricella; Joseph Luft; George deTitta; Helen Neely; Frank Zucker; Wim G J Hol
Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 6):474-8.
2008: Tracy L Arakaki; Frederick S Buckner; John R Gillespie; Nicholas A Malmquist; Margaret A Phillips; Oleksandr Kalyuzhniy; Joseph Luft; George deTitta; Christophe Verlinde; Wesley C Van Voorhis; Wim G J Hol; Ethan A Merritt
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies.
Molecular microbiology 2008;68(1):37-50.
2008: Vivek J Bulbule; Kasey Rivas; Christophe Verlinde; Wesley C Van Voorhis; Michael H Gelb
2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability.
Journal of medicinal chemistry 2008;51(3):384-7.
2008: Ekachai Jenwitheesuk; Jeremy A Horst; Kasey L Rivas; Wesley C Van Voorhis; R Samudrala
Novel paradigms for drug discovery: computational multitarget screening.
Trends in pharmacological sciences 2008;29(2):62-71.
2008: Srinivas Olepu; Praveen Kumar Suryadevara; Kasey Rivas; Kohei Yokoyama; Christophe Verlinde; Debopam Chakrabarti; Wesley C Van Voorhis; Michael H Gelb
2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials.
Bioorganic & medicinal chemistry letters 2008;18(2):494-7.
2008: Kohei Yokoyama; John R Gillespie; Wesley C Van Voorhis; Frederick S Buckner; Michael H Gelb
Protein geranylgeranyltransferase-I of Trypanosoma cruzi.
Molecular and biochemical parasitology 2008;157(1):32-43.
2007: Alejandra B Barrio; Wesley C Van Voorhis; Miguel A Basombrío
Trypanosoma cruzi: attenuation of virulence and protective immunogenicity after monoallelic disruption of the cub gene.
Experimental parasitology 2007;117(4):382-9.
2007: Wesley C Van Voorhis; Kasey Rivas; Pravin Bendale; Laxman Nallan; Carrie Hornéy; Lynn K Barrett; Kevin D Bauer; Brian P Smart; Sudha Ankala; Oliver Hucke; Christophe Verlinde; Debopam Chakrabarti; Corey Strickland; Kohei Yokoyama; Frederick S Buckner; Andrew D Hamilton; David K Williams; Louis J Lombardo; David Floyd; Michael H Gelb
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Antimicrobial agents and chemotherapy 2007;51(10):3659-71.
2007: Pravin Bendale; Srinivas Olepu; Praveen Kumar Suryadevara; Vivek Bulbule; Kasey Rivas; Laxman Nallan; Brian P Smart; Kohei Yokoyama; Sudha Ankala; Prakash Rao Pendyala; David Floyd; Louis J Lombardo; David K Williams; Frederick S Buckner; Debopam Chakrabarti; Christophe Verlinde; Wesley C Van Voorhis; Michael H Gelb
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.
Journal of medicinal chemistry 2007;50(19):4585-605.
2007: John R Gillespie; Kohei Yokoyama; Karen Lu; Richard Eastman; James G Bollinger; Wesley C Van Voorhis; Michael H Gelb; Frederick S Buckner
C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins.
Molecular and biochemical parasitology 2007;153(2):115-24.
2007: Tracy Arakaki; Helen Neely; Erica Boni; Natasha Mueller; Frederick S Buckner; Wesley C Van Voorhis; Angela Lauricella; George deTitta; Joseph Luft; Wim G J Hol; Ethan A Merritt
The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 3):178-82.
2007: Richard Eastman; John White; Oliver Hucke; Kohei Yokoyama; Christophe Verlinde; Michael A Hast; Lorena S Beese; Michael H Gelb; Pradipsinh K Rathod; Wesley C Van Voorhis
Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.
Molecular and biochemical parasitology 2007;152(1):66-71.
2007: Lorenzo Giacani; Barbara J Molini; Charmie Godornes; Lynn Barrett; Wesley C Van Voorhis; Arturo Centurion-Lara; Sheila A Lukehart
Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis.
Infection and immunity 2007;75(1):104-12.
2006: Rebecca E LaFond; Barbara J Molini; Wesley C Van Voorhis; Sheila A Lukehart
Antigenic variation of TprK V regions abrogates specific antibody binding in syphilis.
Infection and immunity 2006;74(11):6244-51.
2006: Jürgen Bosch; Mark A Robien; Christopher Mehlin; Erica Boni; Aaron Riechers; Frederick S Buckner; Wesley C Van Voorhis; Peter J Myler; Elizabeth A Worthey; George deTitta; Joseph Luft; Angela Lauricella; Stacey Gulde; Lori A Anderson; Oleksandr Kalyuzhniy; Helen M Neely; Jenni Ross; Thomas N Earnest; Michael Soltis; Lori Schoenfeld; Frank Zucker; Ethan A Merritt; Erkang Fan; Christophe Verlinde; Wim G J Hol
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
Journal of medicinal chemistry 2006;49(20):5939-46.
2006: Michael H Gelb; Luc Brunsveld; Christine A Hrycyna; Susan Michaelis; Fuyuhiko Tamanoi; Wesley C Van Voorhis; Herbert Waldmann
Therapeutic intervention based on protein prenylation and associated modifications.
Nature chemical biology 2006;2(10):518-28.
2006: Matthew Glenn; Sung-Youn Chang; Carrie Hornéy; Kasey Rivas; Kohei Yokoyama; Erin E Pusateri; Stephen Fletcher; Christopher G Cummings; Frederick S Buckner; Prakash Rao Pendyala; Debopam Chakrabarti; Said M Sebti; Michael H Gelb; Wesley C Van Voorhis; Andrew D Hamilton
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
Journal of medicinal chemistry 2006;49(19):5710-27.
2006: Arturo Centurion-Lara; Barbara J Molini; Charmie Godornes; Eileen S Sun; Karin Hevner; Wesley C Van Voorhis; Sheila A Lukehart
Molecular differentiation of Treponema pallidum subspecies.
Journal of clinical microbiology 2006;44(9):3377-80.
2006: Christopher Mehlin; Erica Boni; Frederick S Buckner; Linnea Engel; Tiffany Feist; Michael H Gelb; Lutfiyah Haji; David Kim; Colleen Liu; Natascha Mueller; Peter J Myler; J T Reddy; Joshua N Sampson; E Subramanian; Wesley C Van Voorhis; Elizabeth A Worthey; Frank Zucker; Wim G J Hol
Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes.
Molecular and biochemical parasitology 2006;148(2):144-60.
2006: Margaret A Holmes; Frederick S Buckner; Wesley C Van Voorhis; Christophe Verlinde; Christopher Mehlin; Erica Boni; George deTitta; Joseph Luft; Angela Lauricella; Lori Anderson; Oleksandr Kalyuzhniy; Frank Zucker; Lori W Schoenfeld; Thomas N Earnest; Wim G J Hol; Ethan A Merritt
Structure of ribose 5-phosphate isomerase from Plasmodium falciparum.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 5):427-31.
2006: Mark A Robien; Jürgen Bosch; Frederick S Buckner; Wesley C Van Voorhis; Elizabeth A Worthey; Peter J Myler; Christopher Mehlin; Erica Boni; Oleksandr Kalyuzhniy; Lori Anderson; Angela Lauricella; Stacey Gulde; Joseph Luft; George deTitta; Jonathan M Caruthers; Keith O Hodgson; Michael Soltis; Frank Zucker; Christophe Verlinde; Ethan A Merritt; Lori W Schoenfeld; Wim G J Hol
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site.
Proteins 2006;62(3):570-7.
2006: Margaret A Holmes; Frederick S Buckner; Wesley C Van Voorhis; Christopher Mehlin; Erica Boni; Thomas N Earnest; George deTitta; Joseph Luft; Angela Lauricella; Lori Anderson; Oleksandr Kalyuzhniy; Frank Zucker; Lori W Schoenfeld; Wim G J Hol; Ethan A Merritt
Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 3):180-5.
2006: Rebecca E LaFond; Arturo Centurion-Lara; Charmie Godornes; Wesley C Van Voorhis; Sheila A Lukehart
TprK sequence diversity accumulates during infection of rabbits with Treponema pallidum subsp. pallidum Nichols strain.
Infection and immunity 2006;74(3):1896-906.
2006: Richard Eastman; Frederick S Buckner; Kohei Yokoyama; Michael H Gelb; Wesley C Van Voorhis
Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation.
Journal of lipid research 2006;47(2):233-40.
2006: Jonathan M Caruthers; Jürgen Bosch; Frederick S Buckner; Wesley C Van Voorhis; Peter J Myler; Elizabeth A Worthey; Christopher Mehlin; Erica Boni; George deTitta; Joseph Luft; Angela Lauricella; Oleksandr Kalyuzhniy; Lori Anderson; Frank Zucker; Michael Soltis; Wim G J Hol
Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum.
Proteins 2006;62(2):338-42.
2005: Richard Eastman; Lynn K Barrett; Kent Dupuis; Frederick S Buckner; Wesley C Van Voorhis
Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation.
Transfusion 2005;45(9):1459-63.
2005: Matthew Glenn; Sung-Youn Chang; Oliver Hucke; Christophe Verlinde; Kasey Rivas; Carrie Hornéy; Kohei Yokoyama; Frederick S Buckner; Prakash Rao Pendyala; Debopam Chakrabarti; Michael H Gelb; Wesley C Van Voorhis; Said M Sebti; Andrew D Hamilton
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Angewandte Chemie (International ed. in English) 2005;44(31):4903-6.
2005: Frederick S Buckner; Richard Eastman; Kohei Yokoyama; Michael H Gelb; Wesley C Van Voorhis
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.
Current opinion in investigational drugs (London, England : 2000) 2005;6(8):791-7.
2005: Laxman Nallan; Kevin D Bauer; Pravin Bendale; Kasey Rivas; Kohei Yokoyama; Carrie Hornéy; Prakash Rao Pendyala; David Floyd; Louis J Lombardo; David K Williams; Andrew Hamilton; Said Sebti; William T Windsor; Patricia C Weber; Frederick S Buckner; Debopam Chakrabarti; Michael H Gelb; Wesley C Van Voorhis
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Journal of medicinal chemistry 2005;48(11):3704-13.
2005: Richard Eastman; John White; Oliver Hucke; Kevin Bauer; Kohei Yokoyama; Laxman Nallan; Debopam Chakrabarti; Christophe Verlinde; Michael H Gelb; Pradipsinh K Rathod; Wesley C Van Voorhis
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
The Journal of biological chemistry 2005;280(14):13554-9.
2005: Malcolm Duthie; Martin S Cetron; Wesley C Van Voorhis; Stuart J Kahn
Trypanosoma cruzi-infected individuals demonstrate varied antibody responses to a panel of trans-sialidase proteins encoded by SA85-1 genes.
Acta tropica 2005;93(3):317-29.
2004: Dora Carrico; Junko Ohkanda; Howard Kendrick; Kohei Yokoyama; Michelle A Blaskovich; Cynthia J Bucher; Frederick S Buckner; Wesley C Van Voorhis; Debopam Chakrabarti; Simon L Croft; Michael H Gelb; Said M Sebti; Andrew D Hamilton
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.
Bioorganic & medicinal chemistry 2004;12(24):6517-26.
2004: Lorenzo Giacani; Eileen S Sun; Karin Hevner; Barbara J Molini; Wesley C Van Voorhis; Sheila A Lukehart; Arturo Centurion-Lara
Tpr homologs in Treponema paraluiscuniculi Cuniculi A strain.
Infection and immunity 2004;72(11):6561-76.
2004: Eileen S Sun; Barbara J Molini; Lynn K Barrett; Arturo Centurion-Lara; Sheila A Lukehart; Wesley C Van Voorhis
Subfamily I Treponema pallidum repeat protein family: sequence variation and immunity.
Microbes and infection / Institut Pasteur 2004;6(8):725-37.
2004: Arturo Centurion-Lara; Rebecca E LaFond; Karin Hevner; Charmie Godornes; Barbara J Molini; Wesley C Van Voorhis; Sheila A Lukehart
Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection.
Molecular microbiology 2004;52(6):1579-96.
2004: Anne Lichtenwalner; Dorothy L Patton; Wesley C Van Voorhis; Yvonne T Cosgrove Sweeney; Cho-Chou Kuo
Heat shock protein 60 is the major antigen which stimulates delayed-type hypersensitivity reaction in the macaque model of Chlamydia trachomatis salpingitis.
Infection and immunity 2004;72(2):1159-61.
2004: Junko Ohkanda; Frederick S Buckner; Jeffrey W Lockman; Kohei Yokoyama; Dora Carrico; Richard Eastman; Kate de Luca-Fradley; Wendy Davies; Simon L Croft; Wesley C Van Voorhis; Michael H Gelb; Said M Sebti; Andrew D Hamilton
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Journal of medicinal chemistry 2004;47(2):432-45.
2003: Frederick S Buckner; Kohei Yokoyama; Jeffrey W Lockman; Kendra Aikenhead; Junko Ohkanda; Martin Sadilek; Said Sebti; Wesley C Van Voorhis; Andrew Hamilton; Michael H Gelb
A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15149-53.
2003: Rebecca E LaFond; Arturo Centurion-Lara; Charmie Godornes; Anne M Rompalo; Wesley C Van Voorhis; Sheila A Lukehart
Sequence diversity of Treponema pallidum subsp. pallidum tprK in human syphilis lesions and rabbit-propagated isolates.
Journal of bacteriology 2003;185(21):6262-8.
2003: Brandon T Leader; Karin Hevner; Barbara J Molini; Lynn K Barrett; Wesley C Van Voorhis; Sheila A Lukehart
Antibody responses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pallidum subsp. pallidum.
Infection and immunity 2003;71(10):6054-7.
2003: Cecilia A Morgan; Sheila A Lukehart; Wesley C Van Voorhis
Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K.
Infection and immunity 2003;71(10):5605-12.
2003: Wesley C Van Voorhis; Lynn K Barrett; Sheila A Lukehart; Bruno Schmidt; Martin Schriefer; Caroline E Cameron
Serodiagnosis of syphilis: antibodies to recombinant Tp0453, Tp92, and Gpd proteins are sensitive and specific indicators of infection by Treponema pallidum.
Journal of clinical microbiology 2003;41(8):3668-74.
2003: Michael H Gelb; Wesley C Van Voorhis; Frederick S Buckner; Kohei Yokoyama; Richard Eastman; Elisabeth P Carpenter; Chrysoula Panethymitaki; Katherine A Brown; Deborah Smith
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.
Molecular and biochemical parasitology 2003;126(2):155-63.
2003: Wesley C Van Voorhis; Lynn K Barrett; Richard Eastman; Ryan D Alfonso; Kent Dupuis
Trypanosoma cruzi inactivation in human platelet concentrates and plasma by a psoralen (amotosalen HCl) and long-wavelength UV.
Antimicrobial agents and chemotherapy 2003;47(2):475-9.
2002: Cecilia A Morgan; Sheila A Lukehart; Wesley C Van Voorhis
Immunization with the N-terminal portion of Treponema pallidum repeat protein K attenuates syphilitic lesion development in the rabbit model.
Infection and immunity 2002;70(12):6811-6.
2002: Frederick S Buckner; David P Kateete; George W Lubega; Wesley C Van Voorhis; Kohei Yokoyama
Trypanosoma brucei prenylated-protein carboxyl methyltransferase prefers farnesylated substrates.
The Biochemical journal 2002;367(Pt 3):809-16.
2002: Francesca Clerici; Maria Luisa Gelmi; Kohei Yokoyama; Donato Pocar; Wesley C Van Voorhis; Frederick S Buckner; Michael H Gelb
Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase.
Bioorganic & medicinal chemistry letters 2002;12(16):2217-20.
2002: Cecilia A Morgan; Barbara J Molini; Sheila A Lukehart; Wesley C Van Voorhis
Segregation of B and T cell epitopes of Treponema pallidum repeat protein K to variable and conserved regions during experimental syphilis infection.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):952-7.
2002: Frederick S Buckner; Richard Eastman; José L Nepomuceno-Silva; Emily C Speelmon; Peter J Myler; Wesley C Van Voorhis; Kohei Yokoyama
Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major.
Molecular and biochemical parasitology 2002;122(2):181-8.
2001: José L Nepomuceno-Silva; Kohei Yokoyama; L D de Mello; S M Mendonca; Julio C Paixão; R Baron; J C Faye; Frederick S Buckner; Wesley C Van Voorhis; M H Gelb; Ulisses G Lopes
TcRho1, a farnesylated Rho family homologue from Trypanosoma cruzi: cloning, trans-splicing, and prenylation studies.
The Journal of biological chemistry 2001;276(32):29711-8.
2001: JC Bressi; Christophe Verlinde; AM Aronov; M L Shaw; S S Shin; Lananh N Nguyen; Stephen Suresh; Frederick S Buckner; Wesley C Van Voorhis; Irwin D Kuntz; Wim G J Hol; Michael H Gelb
Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.
Journal of medicinal chemistry 2001;44(13):2080-93.
2001: Frederick S Buckner; J H Griffin; AJ Wilson; Wesley C Van Voorhis
Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors.
Antimicrobial agents and chemotherapy 2001;45(4):1210-5.
2000: JC Bressi; Jungwoo Choe; M T Hough; Frederick S Buckner; Wesley C Van Voorhis; Christophe Verlinde; Wim G J Hol; Michael H Gelb
Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.
Journal of medicinal chemistry 2000;43(22):4135-50.
2000: F S Buckner; K Yokoyama; L Nguyen; A Grewal; H Erdjument-Bromage; Paul Tempst; C L Strickland; L Xiao; Wesley C Van Voorhis; M H Gelb
Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei.
The Journal of biological chemistry 2000;275(29):21870-6.
2000: Caroline E Cameron; Sheila A Lukehart; C Castro; Barbara J Molini; Charmie Godornes; Wesley C Van Voorhis
Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92.
The Journal of infectious diseases 2000;181(4):1401-13.
2000: Arturo Centurion-Lara; Eileen S Sun; Lynn K Barrett; C Castro; Sheila A Lukehart; Wesley C Van Voorhis
Multiple alleles of Treponema pallidum repeat gene D in Treponema pallidum isolates.
Journal of bacteriology 2000;182(8):2332-5.
2000: Arturo Centurion-Lara; Charmie Godornes; C Castro; Wesley C Van Voorhis; Sheila A Lukehart
The tprK gene is heterogeneous among Treponema pallidum strains and has multiple alleles.
Infection and immunity 2000;68(2):824-31.
1999: Thomas Arroll; Arturo Centurion-Lara; Sheila A Lukehart; Wesley C Van Voorhis
T-Cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infection.
Infection and immunity 1999;67(9):4757-63.
1999: D Weston; A C La Flamme; Wesley C Van Voorhis
Expression of Trypanosoma cruzi surface antigen FL-160 is controlled by elements in the 3' untranslated, the 3' intergenic, and the coding regions.
Molecular and biochemical parasitology 1999;102(1):53-66.
1999: Caroline E Cameron; C Castro; Sheila A Lukehart; Wesley C Van Voorhis
Sequence conservation of glycerophosphodiester phosphodiesterase among Treponema pallidum strains.
Infection and immunity 1999;67(6):3168-70.
1999: AM Aronov; Stephen Suresh; Frederick S Buckner; Wesley C Van Voorhis; Christophe Verlinde; Fred R Opperdoes; Wim G J Hol; Michael H Gelb
Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4273-8.
1999: Arturo Centurion-Lara; C Castro; L Barrett; C Cameron; M Mostowfi; Wesley C Van Voorhis; Sheila A Lukehart
Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune response.
The Journal of experimental medicine 1999;189(4):647-56.
1999: D Weston; B Patel; Wesley C Van Voorhis
Virulence in Trypanosoma cruzi infection correlates with the expression of a distinct family of sialidase superfamily genes.
Molecular and biochemical parasitology 1999;98(1):105-16.
1999: Frederick S Buckner; AJ Wilson; Wesley C Van Voorhis
Detection of live Trypanosoma cruzi in tissues of infected mice by using histochemical stain for beta-galactosidase.
Infection and immunity 1999;67(1):403-9.
1998: Frederick S Buckner; AJ Wilson; T C White; Wesley C Van Voorhis
Induction of resistance to azole drugs in Trypanosoma cruzi.
Antimicrobial agents and chemotherapy 1998;42(12):3245-50.
1998: Caroline E Cameron; C Castro; Sheila A Lukehart; Wesley C Van Voorhis
Function and protective capacity of Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase.
Infection and immunity 1998;66(12):5763-70.
1998: Kohei Yokoyama; PA Trobridge; Frederick S Buckner; Wesley C Van Voorhis; Kenneth D Stuart; Michael H Gelb
Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics.
The Journal of biological chemistry 1998;273(41):26497-505.
1998: Kohei Yokoyama; PA Trobridge; Frederick S Buckner; Jeffrey D Scholten; Kenneth D Stuart; Wesley C Van Voorhis; Michael H Gelb
The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth.
Molecular and biochemical parasitology 1998;94(1):87-97.
1998: Arturo Centurion-Lara; C Castro; R Castillo; JM Shaffer; Wesley C Van Voorhis; Sheila A Lukehart
The flanking region sequences of the 15-kDa lipoprotein gene differentiate pathogenic treponemes.
The Journal of infectious diseases 1998;177(4):1036-40.
1997: A C La Flamme; Stuart J Kahn; Alexander Y Rudensky; Wesley C Van Voorhis
Trypanosoma cruzi-infected macrophages are defective in major histocompatibility complex class II antigen presentation.
European journal of immunology 1997;27(12):3085-94.
1997: Frederick S Buckner; B T Wipke; Wesley C Van Voorhis
Trypanosoma cruzi infection does not impair major histocompatibility complex class I presentation of antigen to cytotoxic T lymphocytes.
European journal of immunology 1997;27(10):2541-8.
1997: C E Stebeck; JM Shaffer; Thomas Arroll; Sheila A Lukehart; Wesley C Van Voorhis
Identification of the Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase homologue.
FEMS microbiology letters 1997;154(2):303-10.
1997: Frederick S Buckner; AJ Wilson; Wesley C Van Voorhis
Trypanosoma cruzi: use of herpes simplex virus-thymidine kinase as a negative selectable marker.
Experimental parasitology 1997;86(3):171-80.
1997: Wesley C Van Voorhis; Lynn K Barrett; Yvonne T Cosgrove Sweeney; Cho-Chou Kuo; Dorothy L Patton
Repeated Chlamydia trachomatis infection of Macaca nemestrina fallopian tubes produces a Th1-like cytokine response associated with fibrosis and scarring.
Infection and immunity 1997;65(6):2175-82.
1997: Arturo Centurion-Lara; C Castro; JM Shaffer; Wesley C Van Voorhis; Christina M Marra; Sheila A Lukehart
Detection of Treponema pallidum by a sensitive reverse transcriptase PCR.
Journal of clinical microbiology 1997;35(6):1348-52.
1997: Arturo Centurion-Lara; Thomas Arroll; R Castillo; JM Shaffer; C Castro; Wesley C Van Voorhis; Sheila A Lukehart
Conservation of the 15-kilodalton lipoprotein among Treponema pallidum subspecies and strains and other pathogenic treponemes: genetic and antigenic analyses.
Infection and immunity 1997;65(4):1440-4.
1996: F S Buckner; Christophe Verlinde; A C La Flamme; Wesley C Van Voorhis
Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase.
Antimicrobial agents and chemotherapy 1996;40(11):2592-7.
1996: Arturo Centurion-Lara; C Castro; Wesley C Van Voorhis; Sheila A Lukehart
Two 16S-23S ribosomal DNA intergenic regions in different Treponema pallidum subspecies contain tRNA genes.
FEMS microbiology letters 1996;143(2-3):235-40.
1996: Wesley C Van Voorhis; L K Barrett; Yvonne T Cosgrove Sweeney; Cho-Chou Kuo; Dorothy L Patton
Analysis of lymphocyte phenotype and cytokine activity in the inflammatory infiltrates of the upper genital tract of female macaques infected with Chlamydia trachomatis.
The Journal of infectious diseases 1996;174(3):647-50.
1996: A C La Flamme; F S Buckner; J Swindle; J Ajioka; Wesley C Van Voorhis
Trypanosoma cruzi: expression of interleukin-2 utilizing both supercoiled plasmids and linear DNAs.
Experimental parasitology 1996;83(1):159-63.
1996: Wesley C Van Voorhis; L K Barrett; J M Nasio; Francis A Plummer; Sheila A Lukehart
Lesions of primary and secondary syphilis contain activated cytolytic T cells.
Infection and immunity 1996;64(3):1048-50.
1996: Wesley C Van Voorhis; L K Barrett; David M Koelle; J M Nasio; Francis A Plummer; Sheila A Lukehart
Primary and secondary syphilis lesions contain mRNA for Th1 cytokines.
The Journal of infectious diseases 1996;173(2):491-5.
1995: A C La Flamme; F S Buckner; J Swindle; J Ajioka; Wesley C Van Voorhis
Expression of mammalian cytokines by Trypanosoma cruzi indicates unique signal sequence requirements and processing.
Molecular and biochemical parasitology 1995;75(1):25-31.
1995: W Conrad Liles; Wesley C Van Voorhis
Review: nomenclature and biologic significance of cytokines involved in inflammation and the host immune response.
The Journal of infectious diseases 1995;172(6):1573-80.
1995: Wesley C Van Voorhis; V T Pham; T De Vos
The FL-160 genes of Trypanosoma cruzi are dispersed on multiple chromosomes.
Experimental parasitology 1995;80(3):578-82.
1994: Arturo Centurion-Lara; L Barrett; Wesley C Van Voorhis
Quantitation of parasitemia by competitive polymerase chain reaction amplification of parasite kDNA minicircles during chronic infection with Trypanosoma cruzi.
The Journal of infectious diseases 1994;170(5):1334-9.
1994: Seymour J Klebanoff; F Kazazi; Wesley C Van Voorhis; K G Schlechte
Activation of the human immunodeficiency virus long terminal repeat in THP-1 cells by a staphylococcal extracellular product.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10615-9.
1994: A C La Flamme; F Buckner; J Swindle; J Ajioka; L Barrett; Wesley C Van Voorhis
Engineering cytokine secretion from Trypanosoma cruzi.
Memórias do Instituto Oswaldo Cruz 1994;89(4):650-1.
1993: M S Cetron; F P Basilio; A P Moraes; A Q Sousa; J N Paes; Stuart J Kahn; M H Wener; Wesley C Van Voorhis
Humoral and cellular immune response of adults from northeastern Brazil with chronic Trypanosoma cruzi infection: depressed cellular immune response to T. cruzi antigen among Chagas' disease patients with symptomatic versus indeterminate infection.
The American journal of tropical medicine and hygiene 1993;49(3):370-82.
1993: Wesley C Van Voorhis; L Barrett; R Koelling; Andrew G Farr
FL-160 proteins of Trypanosoma cruzi are expressed from a multigene family and contain two distinct epitopes that mimic nervous tissues.
The Journal of experimental medicine 1993;178(2):681-94.
1993: S Kahn; M Kahn; Wesley C Van Voorhis; A Goshorn; A Strand; N Hoagland; H Eisen; Sridhar Pennathur
SA85-1 proteins of Trypanosoma cruzi lack sialidase activity.
Molecular and biochemical parasitology 1993;60(1):149-52.
1992: Seymour J Klebanoff; S Olszowski; Wesley C Van Voorhis; Jeffrey A Ledbetter; A M Waltersdorph; K G Schlechte
Effects of gamma-interferon on human neutrophils: protection from deterioration on storage.
Blood 1992;80(1):225-34.
1992: M S Cetron; R Hoff; S Kahn; H Eisen; Wesley C Van Voorhis
Evaluation of recombinant trypomastigote surface antigens of Trypanosoma cruzi in screening sera from a population in rural northeastern Brazil endemic for Chagas' disease.
Acta tropica 1992;50(3):259-66.
1992: Wesley C Van Voorhis
Coculture of human peripheral blood mononuclear cells with Trypanosoma cruzi leads to proliferation of lymphocytes and cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(1):239-48.
1991: Wesley C Van Voorhis; L Schlekewy; H L Trong
Molecular mimicry by Trypanosoma cruzi: the F1-160 epitope that mimics mammalian nerve can be mapped to a 12-amino acid peptide.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):5993-7.
1990: Wesley C Van Voorhis
Therapy and prophylaxis of systemic protozoan infections.
Drugs 1990;40(2):176-202.
1990: S Kahn; Wesley C Van Voorhis; H Eisen
The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes.
The Journal of experimental medicine 1990;172(2):589-97.
1989: Wesley C Van Voorhis; H Eisen
Fl-160. A surface antigen of Trypanosoma cruzi that mimics mammalian nervous tissue.
The Journal of experimental medicine 1989;169(3):641-52.