FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Robert van Waterschoot

Research Profile

Chemicals & Drugs

Living Beings

Concepts & Ideas

Biological Availability

Anatomy

Physiology

Procedures

Administration, Oral

Co-author Network

Publications

TOP 3
Jurjen S Lagas; Jos H Beijnen; Carola W N Damen; Dilek Iusuf; Robert A B van Waterschoot; Alfred H Schinkel
P-glycoprotein, multidrug-resistance associated protein 2, Cyp3a, and carboxylesterase affect the oral availability and metabolism of vinorelbine.
Rob ter Heine; Robert A B van Waterschoot; Ron J Keizer; Jos H Beijnen; Alfred H Schinkel; Alwin D R Huitema
An integrated pharmacokinetic model for the influence of CYP3A4 expression on the in vivo disposition of lopinavir and its modulation by ritonavir.
Robert A B van Waterschoot; Alfred H Schinkel
A critical analysis of the interplay between cytochrome P450 3A and P-glycoprotein: recent insights from knockout and transgenic mice.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Robert van Waterschoot (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Jurjen S Lagas; Jos H Beijnen; Carola W N Damen; Dilek Iusuf; Robert A B van Waterschoot; Alfred H Schinkel
P-glycoprotein, multidrug-resistance associated protein 2, Cyp3a, and carboxylesterase affect the oral availability and metabolism of vinorelbine.
Molecular pharmacology 2012;82(4):636-44.
2011: Rob ter Heine; Robert A B van Waterschoot; Ron J Keizer; Jos H Beijnen; Alfred H Schinkel; Alwin D R Huitema
An integrated pharmacokinetic model for the influence of CYP3A4 expression on the in vivo disposition of lopinavir and its modulation by ritonavir.
Journal of pharmaceutical sciences 2011;100(6):2508-15.
2011: Robert A B van Waterschoot; Alfred H Schinkel
A critical analysis of the interplay between cytochrome P450 3A and P-glycoprotein: recent insights from knockout and transgenic mice.
Pharmacological reviews 2011;63(2):390-410.
2010: Robert A B van Waterschoot; Jurjen S Lagas; Els Wagenaar; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.
International journal of cancer. Journal international du cancer 2010;127(12):2959-64.
2010: Robert A B van Waterschoot; Rob ter Heine; Els Wagenaar; C M M van der Kruijssen; R W Rooswinkel; Alwin D R Huitema; Jos H Beijnen; Alfred H Schinkel
Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir.
British journal of pharmacology 2010;160(5):1224-33.
2010: Jurjen S Lagas; Robert A B van Waterschoot; Rolf W Sparidans; Els Wagenaar; Jos H Beijnen; Alfred H Schinkel
Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation.
Molecular cancer therapeutics 2010;9(2):319-26.
2009: Robert A B van Waterschoot; Jurjen S Lagas; Els Wagenaar; Cornelia M M van der Kruijssen; Antonius E van Herwaarden; Ji-Ying Song; Rogier W Rooswinkel; Olaf van Tellingen; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.
Cancer research 2009;69(23):8996-9002.
2009: Robert A B van Waterschoot; Rogier W Rooswinkel; Rolf W Sparidans; Antonius E van Herwaarden; Jos H Beijnen; Alfred H Schinkel
Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(12):2305-13.
2009: Antonius E van Herwaarden; Robert A B van Waterschoot; Alfred H Schinkel
How important is intestinal cytochrome P450 3A metabolism?
Trends in pharmacological sciences 2009;30(5):223-7.
2009: Jurjen S Lagas; Robert A B van Waterschoot; Vicky A C J van Tilburg; Michel J X Hillebrand; Nienke Lankheet; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2344-51.
2009: Christian Zimmermann; Robert A B van Waterschoot; Stefan Harmsen; Angelika Maier; Heike Gutmann; Alfred H Schinkel
PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;36(4-5):565-71.
2009: Robert A B van Waterschoot; Rogier W Rooswinkel; Els Wagenaar; Cornelia M M van der Kruijssen; Antonius E van Herwaarden; Alfred H Schinkel
Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(1):224-31.
2008: Jurjen S Lagas; Rolf W Sparidans; Robert A B van Waterschoot; Els Wagenaar; Jos H Beijnen; Alfred H Schinkel
P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
Antimicrobial agents and chemotherapy 2008;52(3):1034-9.
2008: Robert A B van Waterschoot; Antonius E van Herwaarden; Jurjen S Lagas; Rolf W Sparidans; Els Wagenaar; Cornelia M M van der Kruijssen; Joyce A Goldstein; Darryl C Zeldin; Jos H Beijnen; Alfred H Schinkel
Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.
Molecular pharmacology 2008;73(3):1029-36.
2007: Antonius E van Herwaarden; Els Wagenaar; Cornelia M M van der Kruijssen; Robert A B van Waterschoot; Johan W Smit; Ji-Ying Song; Martin van der Valk; Olaf van Tellingen; José W A van der Hoorn; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.
The Journal of clinical investigation 2007;117(11):3583-92.
2007: Chris de Graaf; Chris Oostenbrink; Peter H J Keizers; Barbara M A van Vugt-Lussenburg; Robert A B van Waterschoot; Richard A Tschirret-Guth; Jan N M Commandeur; Nico P E Vermeulen
Molecular modeling-guided site-directed mutagenesis of cytochrome P450 2D6.
Current drug metabolism 2007;8(1):59-77.
2006: Robert A B van Waterschoot; Peter H J Keizers; Chris de Graaf; Nico P E Vermeulen; Richard A Tschirret-Guth
Topological role of cytochrome P450 2D6 active site residues.
Archives of biochemistry and biophysics 2006;447(1):53-8.