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Albert van Zeeland

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Physiology

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Patricia Cramers; Esther E Verhoeven; A Ronald Filon; Davy A P Rockx; Susy J Santos; Anneke Van Hoffen; Jos C S Kleinjans; Albert A van Zeeland; Leon H F Mullenders
Impaired repair of ionizing radiation-induced DNA damage in Cockayne syndrome cells.
René M Overmeer; Jill Moser; Marcel Volker; Hanneke Kool; Alan E Tomkinson; Albert A van Zeeland; Leon H F Mullenders; Maria Fousteri
Replication protein A safeguards genome integrity by controlling NER incision events.
Maaike P G Vreeswijk; Carel Meijers; Micheline Giphart-Gassler; Harry Vrieling; Albert A van Zeeland; Leon H F Mullenders; Wil A M Loenen
Site-specific analysis of UV-induced cyclobutane pyrimidine dimers in nucleotide excision repair-proficient and -deficient hamster cells: Lack of correlation with mutational spectra.

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2011: Patricia Cramers; Esther E Verhoeven; A Ronald Filon; Davy A P Rockx; Susy J Santos; Anneke Van Hoffen; Jos C S Kleinjans; Albert A van Zeeland; Leon H F Mullenders
Impaired repair of ionizing radiation-induced DNA damage in Cockayne syndrome cells.
Radiation research 2011;175(4):432-43.
2011: René M Overmeer; Jill Moser; Marcel Volker; Hanneke Kool; Alan E Tomkinson; Albert A van Zeeland; Leon H F Mullenders; Maria Fousteri
Replication protein A safeguards genome integrity by controlling NER incision events.
The Journal of cell biology 2011;192(3):401-15.
2009: Maaike P G Vreeswijk; Carel Meijers; Micheline Giphart-Gassler; Harry Vrieling; Albert A van Zeeland; Leon H F Mullenders; Wil A M Loenen
Site-specific analysis of UV-induced cyclobutane pyrimidine dimers in nucleotide excision repair-proficient and -deficient hamster cells: Lack of correlation with mutational spectra.
Mutation research 2009;663(1-2):7-14.
2008: Albert A van Zeeland; Anton J de Groot; Georges R Mohn; Harry van Steeg; Conny Th M van Oostrom; Anne-Marie van Duijn-Goedhart; Leon F H Mullenders; Jacob G Jansen
Reduced methylation-induced mutagenesis in rat splenocytes in vivo by sub-chronic low dose exposure to N-metyl-N-nitrosourea.
Mutation research 2008;640(1-2):131-8.
2007: Femke A T de Vries; José B M Zonneveld; Anton J de Groot; Roman I Koning; Albert A van Zeeland; Albert Pastink
Schizosaccharomyces pombe Rad22A and Rad22B have similar biochemical properties and form multimeric structures.
Mutation research 2007;615(1-2):143-52.
2007: Caroline G C van der Wees; Jacob Jansen; Harry Vrieling; Arnoud van der Laarse; Albert A van Zeeland; Leon H F Mullenders
Nucleotide excision repair in differentiated cells.
Mutation research 2007;614(1-2):16-23.
2006: Maria Fousteri; Wim Vermeulen; Albert A van Zeeland; Leon H F Mullenders
Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.
Molecular cell 2006;23(4):471-82.
2005: Patricia Cramers; Petya Atanasova; Hans Vrolijk; Firouz Darroudi; Albert A van Zeeland; rene huiskamp; Leon H F Mullenders; Jos C S Kleinjans
Pre-exposure to low doses: modulation of X-ray-induced dna damage and repair?
Radiation research 2005;164(4 Pt 1):383-90.
2005: Femke A T de Vries; José B M Zonneveld; Annemarie van Duijn-Goedhart; Marianne Roodbergen; J J W A Boei; Paul P W van Buul; Jeroen Essers; Harry van Steeg; Albert A van Zeeland; Jan van Benthem; Albert Pastink
Inactivation of RAD52 aggravates RAD54 defects in mice but not in Schizosaccharomyces pombe.
DNA repair 2005;4(10):1121-8.
2005: Albert A van Zeeland; Maaike P G Vreeswijk; Frank R de Gruijl; Henk J van Kranen; Harry Vrieling; Leon F H Mullenders
Transcription-coupled repair: impact on UV-induced mutagenesis in cultured rodent cells and mouse skin tumors.
Mutation research 2005;577(1-2):170-8.
2005: Femke A T de Vries; Esther de Boer; Michael van den Bosch; Willy M Baarends; Marja Ooms; Li Yuan; Jian-Guo Liu; Albert A van Zeeland; Christa Heyting; Albert Pastink
Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation.
Genes & development 2005;19(11):1376-89.
2005: Jill Moser; Marcel Volker; Hanneke Kool; Sergei Alekseev; Harry Vrieling; Akira Yasui; Albert A van Zeeland; Leon H F Mullenders
The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions.
DNA repair 2005;4(5):571-82.
2005: Marjan Boerma; Caroline G C van der Wees; Harry Vrieling; J Peter Svensson; Jan Wondergem; Arnoud van der Laarse; Leon H F Mullenders; Albert A van Zeeland
Microarray analysis of gene expression profiles of cardiac myocytes and fibroblasts after mechanical stress, ionising or ultraviolet radiation.
BMC genomics 2005;6():6.
2004: Lydia Riou; Eric Eveno; Anneke Van Hoffen; Albert A van Zeeland; Alain Sarasin; Leon H F Mullenders
Differential repair of the two major UV-induced photolesions in trichothiodystrophy fibroblasts.
Cancer research 2004;64(3):889-94.
2003: Caroline G C van der Wees; Maaike P G Vreeswijk; Marion Persoon; Arnoud van der Laarse; Albert A van Zeeland; Leon H F Mullenders
Deficient global genome repair of UV-induced cyclobutane pyrimidine dimers in terminally differentiated myocytes and proliferating fibroblasts from the rat heart.
DNA repair 2003;2(12):1297-308.
2003: Anneke Van Hoffen; Adayabalam S Balajee; Albert A van Zeeland; Leon H F Mullenders
Nucleotide excision repair and its interplay with transcription.
Toxicology 2003;193(1-2):79-90.
2003: Suzanne Rademakers; Marcel Volker; Deborah Hoogstraten; Alex L Nigg; Martijn J Moné; Albert A van Zeeland; Jan H J Hoeijmakers; Adriaan B Houtsmuller; Wim Vermeulen
Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions.
Molecular and cellular biology 2003;23(16):5755-67.
2003: Barbara Tudek; Zygmunt Ciesla; Celina Janion; Serge Boiteux; Katarzyna Bebenek; Hideo Shinagawa; Helmut Bartsch; Jacques Laval; Albert A van Zeeland; Leon F H Mullenders; Krzysztof Szyfter; Andrew Collins; Marcin Kruszewski
32nd annual meeting of European Environmental Mutagen Society. DNA damage and repair fundamental aspects and contribution to human disorders.
DNA repair 2003;2(6):765-81.
2002: Marjan Boerma; Caroline G C van der Wees; Jan Wondergem; Arnoud van der Laarse; M Persoon; Albert A van Zeeland; Leon H F Mullenders
Separation of neonatal rat ventricular myocytes and non-myocytes by centrifugal elutriation.
Pflügers Archiv : European journal of physiology 2002;444(3):452-6.
2001: Martijn J Moné; Marcel Volker; O Nikaido; Leon H F Mullenders; Albert A van Zeeland; Pernette J Verschure; Erik Manders; Roel Van Driel
Local UV-induced DNA damage in cell nuclei results in local transcription inhibition.
EMBO reports 2001;2(11):1013-7.
2001: Jamal M Arif; Manicka V Vadhanam; Anton J de Groot; Albert A van Zeeland; C Gary Gairola; Ramesh C Gupta
Effect of cigarette smoke exposure on the modulation of 8-oxo-2'-deoxyguanosine in rat lungs as analyzed by 32P-postlabeling and HPLC-ECD.
International journal of oncology 2001;19(4):763-6.
2001: Marcel Volker; Martijn J Moné; parimal karmakar; Anneke Van Hoffen; W Schul; Wim Vermeulen; Jan H J Hoeijmakers; Roel Van Driel; Albert A van Zeeland; Leon H F Mullenders
Sequential assembly of the nucleotide excision repair factors in vivo.
Molecular cell 2001;8(1):213-24.
2001: Susan W P Wijnhoven; Hanneke Kool; Leon H F Mullenders; R Slater; Albert A van Zeeland; Harry Vrieling
DMBA-induced toxic and mutagenic responses vary dramatically between NER-deficient Xpa, Xpc and Csb mice.
Carcinogenesis 2001;22(7):1099-106.
2001: Albert A van Zeeland; Leon H F Mullenders; Harry Vrieling
Gene and sequence specificity of DNA damage induction and repair: consequences for mutagenesis.
Mutation research 2001;485(1):15-21.
2001: Susan W P Wijnhoven; Hanneke Kool; Corrie M M van Teijlingen; Albert A van Zeeland; Harry Vrieling
Loss of heterozygosity in somatic cells of the mouse. An important step in cancer initiation?
Mutation research 2001;473(1):23-36.
2000: Susan W P Wijnhoven; Hanneke Kool; Conny Th M van Oostrom; Rudolf B Beems; Leon H F Mullenders; Albert A van Zeeland; Gijsbertus T J van der Horst; Harry Vrieling; Harry van Steeg
The relationship between benzo[a]pyrene-induced mutagenesis and carcinogenesis in repair-deficient Cockayne syndrome group B mice.
Cancer research 2000;60(20):5681-7.
2000: Susan W P Wijnhoven; Hanneke Kool; Leon H F Mullenders; Albert A van Zeeland; Errol C Friedberg; Gijsbertus T J van der Horst; Harry van Steeg; Harry Vrieling
Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair.
Oncogene 2000;19(43):5034-7.
2000: Marijke van Oosten; Heggert Rebel; Errol C Friedberg; Harry van Steeg; Gijsbertus T J van der Horst; Henk J van Kranen; Anja Westerman; Albert A van Zeeland; Leon H F Mullenders; Frank R de Gruijl
Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11268-73.
2000: D A Rockx; R Mason; Anneke Van Hoffen; M C Barton; E Citterio; D B Bregman; Albert A van Zeeland; Harry Vrieling; Leon H F Mullenders
UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10503-8.
1999: Petra P H Van Sloun; Jacob G Jansen; G Weeda; Leon H F Mullenders; Albert A van Zeeland; Paul H M Lohman; Harry Vrieling
The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage.
Nucleic acids research 1999;27(16):3276-82.
1999: Anneke Van Hoffen; W H Kalle; A de Jong-Versteeg; Alan Lehmann; Albert A van Zeeland; Leon H F Mullenders
Cells from XP-D and XP-D-CS patients exhibit equally inefficient repair of UV-induced damage in transcribed genes but different capacity to recover UV-inhibited transcription.
Nucleic acids research 1999;27(14):2898-904.
1999: SA Bol; Harry van Steeg; Conny Th M van Oostrom; Ad D Tates; Harry Vrieling; Anton J de Groot; Leon H F Mullenders; Albert A van Zeeland; Jacob G Jansen
Nucleotide excision repair modulates the cytotoxic and mutagenic effects of N-n-butyl-N-nitrosourea in cultured mammalian cells as well as in mouse splenocytes in vivo.
Mutagenesis 1999;14(3):317-22.
1999: Fabienne Calléja; Jacob G Jansen; Harry Vrieling; F Laval; Albert A van Zeeland
Modulation of the toxic and mutagenic effects induced by methyl methanesulfonate in Chinese hamster ovary cells by overexpression of the rat N-alkylpurine-DNA glycosylase.
Mutation research 1999;425(2):185-94.
1999: Albert A van Zeeland; Anton J de Groot; J Hall; F Donato
8-Hydroxydeoxyguanosine in DNA from leukocytes of healthy adults: relationship with cigarette smoking, environmental tobacco smoke, alcohol and coffee consumption.
Mutation research 1999;439(2):249-57.
1999: Harry Vrieling; Susan W P Wijnhoven; Petra P H Van Sloun; Hanneke Kool; Micheline Giphart-Gassler; Albert A van Zeeland
Heterozygous Aprt mouse model: detection and study of a broad range of autosomal somatic mutations in vivo.
Environmental and molecular mutagenesis 1999;34(2-3):84-9.
1999: Albert A van Zeeland; Harry Vrieling
Mutation in mammalian cells in vitro and in vivo as indicators of exposure to carcinogens.
IARC scientific publications 1999;(146):355-65.
1998: Susan W P Wijnhoven; Petra P H Van Sloun; Hanneke Kool; G Weeda; R Slater; Paul H M Lohman; Albert A van Zeeland; Harry Vrieling
Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13759-64.
1998: Petra P H Van Sloun; Susan W P Wijnhoven; Hanneke Kool; R Slater; G Weeda; Albert A van Zeeland; Paul H M Lohman; Harry Vrieling
Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice.
Nucleic acids research 1998;26(21):4888-94.
1998: Maaike P G Vreeswijk; M W Overkamp; B E Westland; Sandrine van Hees-Stuivenberg; Harry Vrieling; Malgorzata Z Zdzienicka; Albert A van Zeeland; Leon H F Mullenders
Enhanced UV-induced mutagenesis in the UV61 cell line, the Chinese hamster homologue of Cockayne's syndrome B, is associated with defective transcription coupled repair of cyclobutane pyrimidine dimers.
Mutation research 1998;409(1):49-56.
1998: R H Elder; Jacob G Jansen; Robert Weeks; MA Willington; B Deans; Amanda J Watson; K J Mynett; J A Bailey; Donald P Cooper; Joseph Rafferty; M C Heeran; Susan W P Wijnhoven; Albert A van Zeeland; Geoffrey P Margison
Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.
Molecular and cellular biology 1998;18(10):5828-37.
1998: P Karmarkar; A Leer-van Hoffen; Adayapalam T Natarajan; Albert A van Zeeland; Leon H F Mullenders
UV-induced alterations in the spatial distribution of the basal transcription factor TFIIH: an early event in nucleotide excision repair.
Mutation research 1998;404(1-2):129-31.
1998: SA Bol; Harry van Steeg; Jacob G Jansen; Conny Th M van Oostrom; Annemieke de Vries; Anton J de Groot; Ad D Tates; Harry Vrieling; Albert A van Zeeland; Leon H F Mullenders
Elevated frequencies of benzo(a)pyrene-induced Hprt mutations in internal tissue of XPA-deficient mice.
Cancer research 1998;58(13):2850-6.
1998: Michiel F van Oosterwijk; R Filon; Anton J de Groot; Albert A van Zeeland; Leon H F Mullenders
Lack of transcription-coupled repair of acetylaminofluorene DNA adducts in human fibroblasts contrasts their efficient inhibition of transcription.
The Journal of biological chemistry 1998;273(22):13599-604.
1998: Harry Vrieling; Albert A van Zeeland; Leon H F Mullenders
Transcription coupled repair and its impact on mutagenesis.
Mutation research 1998;400(1-2):135-42.
1998: Maaike P G Vreeswijk; B E Westland; Martin T Hess; Hanspeter Naegeli; Harry Vrieling; Albert A van Zeeland; Leon H F Mullenders
Impairment of nucleotide excision repair by apoptosis in UV-irradiated mouse cells.
Cancer research 1998;58(9):1978-85.
1998: Peter J Abrahams; Ada Houweling; Paulien Cornelissen-Steijger; Nicolaas G J Jaspers; Firouz Darroudi; Carel Meijers; Leon H F Mullenders; R Filon; Fré Arwert; HERBERT PINEDO; A P Natarajan; Carrol Terleth; Albert A van Zeeland; Alex J van der Eb
Impaired DNA repair capacity in skin fibroblasts from various hereditary cancer-prone syndromes.
Mutation research 1998;407(2):189-201.
1998: Barbara Tudek; Albert A van Zeeland; Jaroslaw T Kusmierek; Jacques Laval
Activity of Escherichia coli DNA-glycosylases on DNA damaged by methylating and ethylating agents and influence of 3-substituted adenine derivatives.
Mutation research 1998;407(2):169-76.
1998: C W Op het Veld; J Jansen; Malgorzata Z Zdzienicka; Harry Vrieling; Albert A van Zeeland
Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11.
Mutation research 1998;398(1-2):83-92.
1997: C W Op het Veld; Sandrine van Hees-Stuivenberg; Albert A van Zeeland; Jacob G Jansen
Effect of nucleotide excision repair on hprt gene mutations in rodent cells exposed to DNA ethylating agents.
Mutagenesis 1997;12(6):417-24.
1997: Barbara Pascucci; A Versteegh; Anneke Van Hoffen; Albert A van Zeeland; Leon H F Mullenders; Eugenia Dogliotti
DNA repair of UV photoproducts and mutagenesis in human mitochondrial DNA.
Journal of molecular biology 1997;273(2):417-27.
1997: SA Bol; Anton J de Groot; RB Tijdens; John Meerman; Leon H F Mullenders; Albert A van Zeeland
Electrochemical detection and quantification of the acetylated and deacetylated C8-deoxyguanosine DNA adducts induced by 2-acetylaminofluorene.
Analytical biochemistry 1997;251(1):24-31.
1997: David L Cheo; Henk Ruven; Lisiane Meira; RE Hammer; Dennis K Burns; N J Tappe; Albert A van Zeeland; Leon H F Mullenders; Errol C Friedberg
Characterization of defective nucleotide excision repair in XPC mutant mice.
Mutation research 1997;374(1):1-9.
1997: K Bouayadi; Anneke Van Hoffen; Adayabalam S Balajee; A T Natarajan; Albert A van Zeeland; Leon H F Mullenders
Enzymatic activities involved in the DNA resynthesis step of nucleotide excision repair are firmly attached to chromatin.
Nucleic acids research 1997;25(5):1056-63.
1997: A F Frijhoff; Heggert Rebel; E J Mientjes; M C Kelders; Marie-Jose S T Steenwinkel; RA Baan; Albert A van Zeeland; L Roza
UVB-induced mutagenesis in hairless lambda lacZ-transgenic mice.
Environmental and molecular mutagenesis 1997;29(2):136-42.
1997: Joost H M van Delft; Marie-Jose S T Steenwinkel; Anton J de Groot; Albert A van Zeeland; G Eberle-Adamkiewicz; Manfred F Rajewsky; Jürgen Thomale; RA Baan
Determination of N7- and O6-methylguanine in rat liver DNA after oral exposure to hydrazine by use of immunochemical and electrochemical detection methods.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1997;35(1):131-7.
1997: Leon H F Mullenders; Anneke Van Hoffen; Maaike P G Vreeswijk; Henk Ruven; Harry Vrieling; Albert A van Zeeland
Ultraviolet-induced photolesions: repair and mutagenesis.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1997;143():89-99.
1996: M F van Oosterwijk; R Filon; W H Kalle; Leon H F Mullenders; Albert A van Zeeland
The sensitivity of human fibroblasts to N-acetoxy-2-acetylaminofluorene is determined by the extent of transcription-coupled repair, and/or their capability to counteract RNA synthesis inhibition.
Nucleic acids research 1996;24(23):4653-9.
1996: Jacob G Jansen; Anton J de Groot; C M van Teijlingen; Ad D Tates; Harry Vrieling; Albert A van Zeeland
Induction of hprt gene mutations in splenic T-lymphocytes from the rat exposed in vivo to DNA methylating agents is correlated with formation of O6-methylguanine in bone marrow and not in the spleen.
Carcinogenesis 1996;17(10):2183-91.
1996: M F van Oosterwijk; A Versteeg; R Filon; Albert A van Zeeland; Leon H F Mullenders
The sensitivity of Cockayne's syndrome cells to DNA-damaging agents is not due to defective transcription-coupled repair of active genes.
Molecular and cellular biology 1996;16(8):4436-44.
1996: Albert A van Zeeland
Molecular dosimetry of chemical mutagens. Relationship between DNA adduct formation and genetic changes analyzed at the molecular level.
Mutation research 1996;353(1-2):123-50.
1995: Albert A van Zeeland; Jacob G Jansen; G R Mohn; Harry Vrieling; Ad D Tates; Paul H M Lohman
Detection of point mutations in T lymphocytes.
Clinical chemistry 1995;41(12 Pt 2):1841-3.
1995: Jacob G Jansen; Harry Vrieling; C M van Teijlingen; G R Mohn; Ad D Tates; Albert A van Zeeland
Marked differences in the role of O6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrosourea, or N-ethyl-N-nitrosourea.
Cancer research 1995;55(9):1875-82.
1995: Albert A van Zeeland; Jacob G Jansen; A de Groot; S van Hees; C M van Teijlingen; C W op het Veld; Malgorzata Z Zdzienicka; Paul H M Lohman; Harry Vrieling
Mechanisms and biomarkers of genotoxicity. Molecular dosimetry of chemical mutagens.
Toxicology letters 1995;77(1-3):49-54.
1995: Anneke Van Hoffen; J Venema; R Meschini; Albert A van Zeeland; Leon H F Mullenders
Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts.
The EMBO journal 1995;14(2):360-7.
1994: Maaike P G Vreeswijk; Anneke Van Hoffen; B E Westland; Harry Vrieling; Albert A van Zeeland; Leon H F Mullenders
Analysis of repair of cyclobutane pyrimidine dimers and pyrimidine 6-4 pyrimidone photoproducts in transcriptionally active and inactive genes in Chinese hamster cells.
The Journal of biological chemistry 1994;269(50):31858-63.
1994: Henk Ruven; C M Seelen; Paul H M Lohman; Henk J van Kranen; Albert A van Zeeland; Leon H F Mullenders
Strand-specific removal of cyclobutane pyrimidine dimers from the p53 gene in the epidermis of UVB-irradiated hairless mice.
Oncogene 1994;9(12):3427-32.
1994: Jacob G Jansen; C M van Teijlingen; G R Mohn; Albert A van Zeeland; Harry Vrieling
AT base pairs are the main target for mutations at the hprt locus of rat skin fibroblasts exposed in vitro to the monofunctional alkylating agent N-ethyl-N-nitrosourea.
Mutagenesis 1994;9(5):417-21.
1994: Henk Ruven; C M Seelen; Paul H M Lohman; Leon H F Mullenders; Albert A van Zeeland
Efficient synthesis of 32P-labeled single-stranded DNA probes using linear PCR; application of the method for analysis of strand-specific DNA repair.
Mutation research 1994;315(2):189-95.
1994: C W Op het Veld; Malgorzata Z Zdzienicka; Harry Vrieling; Paul H M Lohman; Albert A van Zeeland
Molecular analysis of ethyl methanesulfonate-induced mutations at the hprt gene in the ethyl methanesulfonate-sensitive Chinese hamster cell line EM-C11 and its parental line CHO9.
Cancer research 1994;54(11):3001-6.
1994: Jacob G Jansen; G R Mohn; Harry Vrieling; C M van Teijlingen; Paul H M Lohman; Albert A van Zeeland
Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.
Cancer research 1994;54(9):2478-85.
1994: Jacob G Jansen; Anton J de Groot; C M van Teijlingen; Paul H M Lohman; G R Mohn; Harry Vrieling; Albert A van Zeeland
Formation and persistence of DNA adducts in pouch skin fibroblasts and liver tissue of rats exposed in vivo to the monofunctional alkylating agents N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.
Mutation research 1994;307(1):95-105.
1994: Anton J de Groot; Jacob G Jansen; C F van Valkenburg; Albert A van Zeeland
Molecular dosimetry of 7-alkyl- and O6-alkylguanine in DNA by electrochemical detection.
Mutation research 1994;307(1):61-6.
1994: B Klein; A R Filon; Albert A van Zeeland; Alex J van der Eb
Survival of UV-irradiated vaccinia virus in normal and xeroderma pigmentosum fibroblasts; evidence for repair of UV-damaged viral DNA.
Mutation research 1994;307(1):25-32.
1993: Anneke Van Hoffen; Adayapalam T Natarajan; L V Mayne; Albert A van Zeeland; Leon H F Mullenders; J Venema
Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells.
Nucleic acids research 1993;21(25):5890-5.
1993: Leon H F Mullenders; A M Hazekamp-van Dokkum; W H Kalle; Harry Vrieling; Malgorzata Z Zdzienicka; Albert A van Zeeland
UV-induced photolesions, their repair and mutations.
Mutation research 1993;299(3-4):271-6.
1993: Henk Ruven; Rob J W Berg; C M Seelen; J A Dekkers; Paul H M Lohman; Leon H F Mullenders; Albert A van Zeeland
Ultraviolet-induced cyclobutane pyrimidine dimers are selectively removed from transcriptionally active genes in the epidermis of the hairless mouse.
Cancer research 1993;53(7):1642-5.
1993: Paola Fortini; A Calcagnile; H Vrieling; Albert A van Zeeland; Margherita Bignami; Eugenia Dogliotti
Mutagenic processing of ethylation damage in mammalian cells: the use of methoxyamine to study apurinic/apyrimidinic site-induced mutagenesis.
Cancer research 1993;53(5):1149-55.
1993: W H Kalle; A M Hazekamp-van Dokkum; P H Lohman; A T Natarajan; Albert A van Zeeland; Leon H F Mullenders
The use of streptavidin-coated magnetic beads and biotinylated antibodies to investigate induction and repair of DNA damage: analysis of repair patches in specific sequences of uv-irradiated human fibroblasts.
Analytical biochemistry 1993;208(2):228-36.
1992: Harry Vrieling; Ad D Tates; Adayapalam T Natarajan; Albert A van Zeeland
Age-related accumulation of mutations in human T-lymphocytes.
Annals of the New York Academy of Sciences 1992;663():36-42.
1992: Paul H M Lohman; Bruno Morolli; Firouz Darroudi; Adayapalam T Natarajan; J A Gossen; J Venema; Leon H F Mullenders; Ekkehart W Vogel; Harry Vrieling; Albert A van Zeeland
Contributions from molecular/biochemical approaches in epidemiology to cancer risk assessment and prevention.
Environmental health perspectives 1992;98():155-65.
1992: Harry Vrieling; J C Thijssen; A M Rossi; FJ van Dam; Adayapalam T Natarajan; Ad D Tates; Albert A van Zeeland
Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population.
Carcinogenesis 1992;13(9):1625-31.
1992: Harry Vrieling; L H Zhang; Albert A van Zeeland; Malgorzata Z Zdzienicka
UV-induced hprt mutations in a UV-sensitive hamster cell line from complementation group 3 are biased towards the transcribed strand.
Mutation research 1992;274(2):147-55.
1992: J Venema; Z Bartosová; Adayapalam T Natarajan; Albert A van Zeeland; Leon H F Mullenders
Transcription affects the rate but not the extent of repair of cyclobutane pyrimidine dimers in the human adenosine deaminase gene.
The Journal of biological chemistry 1992;267(13):8852-6.
1992: Jacob G Jansen; Harry Vrieling; Albert A van Zeeland; G R Mohn
The gene encoding hypoxanthine-guanine phosphoribosyltransferase as target for mutational analysis: PCR cloning and sequencing of the cDNA from the rat.
Mutation research 1992;266(2):105-16.
1992: A M Rossi; Ad D Tates; Albert A van Zeeland; Harry Vrieling
Molecular analysis of mutations affecting hprt mRNA splicing in human T-lymphocytes in vivo.
Environmental and molecular mutagenesis 1992;19(1):7-13.
1992: Malgorzata Z Zdzienicka; J Venema; D L Mitchell; Anneke Van Hoffen; Albert A van Zeeland; Harry Vrieling; Leon H F Mullenders; Paul H M Lohman; J W Simons
(6-4) photoproducts and not cyclobutane pyrimidine dimers are the main UV-induced mutagenic lesions in Chinese hamster cells.
Mutation research 1992;273(1):73-83.
1991: P Menichini; Harry Vrieling; Albert A van Zeeland
Strand-specific mutation spectra in repair-proficient and repair-deficient hamster cells.
Mutation research 1991;251(1):143-55.
1991: Leon H F Mullenders; Harry Vrieling; J Venema; Albert A van Zeeland
Hierarchies of DNA repair in mammalian cells: biological consequences.
Mutation research 1991;250(1-2):223-8.
1991: J Venema; Anneke Van Hoffen; V Karcagi; Adayapalam T Natarajan; Albert A van Zeeland; Leon H F Mullenders
Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes.
Molecular and cellular biology 1991;11(8):4128-34.
1991: Harry Vrieling; J Venema; M L van Rooyen; Anneke Van Hoffen; P Menichini; Malgorzata Z Zdzienicka; J W Simons; Leon H F Mullenders; Albert A van Zeeland
Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene.
Nucleic acids research 1991;19(9):2411-5.
1991: Malgorzata Z Zdzienicka; D L Mitchell; J Venema; Anneke Van Hoffen; Albert A van Zeeland; Leon H F Mullenders; J de Wit; J W Simons
DNA repair characteristics and mutability of the UV-sensitive V79 Chinese hamster cell mutant V-B11 (complementation group 7).
Mutagenesis 1991;6(3):179-83.
1990: A M Rossi; J C Thijssen; Ad D Tates; Harry Vrieling; Adayapalam T Natarajan; Paul H M Lohman; Albert A van Zeeland
Mutations affecting RNA splicing in man are detected more frequently in somatic than in germ cells.
Mutation research 1990;244(4):353-7.
1990: Albert A van Zeeland; A de Groot; A Neuhäuser-Klaus
DNA adduct formation in mouse testis by ethylating agents: a comparison with germ-cell mutagenesis.
Mutation research 1990;231(1):55-62.
1990: J Venema; Leon H F Mullenders; Adayapalam T Natarajan; Albert A van Zeeland; L V Mayne
The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4707-11.
1990: J Venema; Anneke Van Hoffen; Adayapalam T Natarajan; Albert A van Zeeland; Leon H F Mullenders
The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA.
Nucleic acids research 1990;18(3):443-8.
1990: Albert A van Zeeland; Harry Vrieling; M L van Rooijen; J Venema; Malgorzata Z Zdzienicka; J W Simons; Leon H F Mullenders; Paul H M Lohman
Influence of DNA excision repair on UV-induced mutation spectra in Chinese hamster cells.
Progress in clinical and biological research 1990;340A():249-54.
1990: Leon H F Mullenders; J Venema; Anneke Van Hoffen; L V Mayne; Adayapalam T Natarajan; Albert A van Zeeland
The role of the nuclear matrix in DNA repair.
Progress in clinical and biological research 1990;340A():223-32.
1989: Harry Vrieling; M L Van Rooijen; N A Groen; Malgorzata Z Zdzienicka; J W Simons; Paul H M Lohman; Albert A van Zeeland
DNA strand specificity for UV-induced mutations in mammalian cells.
Molecular and cellular biology 1989;9(3):1277-83.
1988: Leon H F Mullenders; A C van Kesteren van Leeuwen; Albert A van Zeeland; Adayapalam T Natarajan
Nuclear matrix associated DNA is preferentially repaired in normal human fibroblasts, exposed to a low dose of ultraviolet light but not in Cockayne's syndrome fibroblasts.
Nucleic acids research 1988;16(22):10607-22.
1988: Adayapalam T Natarajan; Albert A van Zeeland; G Obe
Some studies on the DNA-repair-eliciting and genotoxic activity of cell-free extracts of Lactobacillus bifidus.
Mutation research 1988;206(1):47-54.
1988: Albert A van Zeeland
Molecular dosimetry of alkylating agents: quantitative comparison of genetic effects on the basis of DNA adduct formation.
Mutagenesis 1988;3(3):179-91.
1988: Harry Vrieling; J W Simons; Albert A van Zeeland
Nucleotide sequence determination of point mutations at the mouse HPRT locus using in vitro amplification of HPRT mRNA sequences.
Mutation research 1988;198(1):107-13.
1988: Harry Vrieling; M J Niericker; J W Simons; Albert A van Zeeland
Molecular analysis of mutations induced by N-ethyl-N-nitrosourea at the HPRT locus in mouse lymphoma cells.
Mutation research 1988;198(1):99-106.
1988: Malgorzata Z Zdzienicka; Govert P van der Schans; A Westerveld; Albert A van Zeeland; J W Simons
Phenotypic heterogeneity within the first complementation group of UV-sensitive mutants of Chinese hamster cell lines.
Mutation research 1988;193(1):31-41.
1987: Leon H F Mullenders; Albert A van Zeeland; Adayapalam T Natarajan
The localization of ultraviolet-induced excision repair in the nucleus and the distribution of repair events in higher order chromatin loops in mammalian cells.
Journal of cell science. Supplement 1987;6():243-62.