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Todd Vanderah

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Ravil R Petrov; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Josephine Lai; Yeon Sun Lee; Lu Liu; Shou-wu Ma; Peg Davis; Victor J Hruby
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Alysia N Lozano-Ondoua; Patrick W Mantyh; Mark A Nelson; Tijana Nikolich-Zugich; Mabel Owusu-Ankomah; Frank Porreca; Ashley M Symons-Liguori; Aaron P Bloom; Anupama Chandramouli; Henry L Ferland; Katherine E Hanlon; Josh J Havelin; Juan Miguel Jimenez-Andrade; Tamara King; Tally M Largent-Milnes; Todd W Vanderah
Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists.
Rebecca Edelmayer; Pierangelo Geppetti; Larry N Le; Serena Materazzi; Romina Nassini; Frank Porreca; Delia Preti; Todd W Vanderah; Xiaomei Wei; Jin Yan; Giovanni Appendino; David W Dodick; G Dussor
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain.

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All Publications

2013: Ravil R Petrov; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Josephine Lai; Yeon Sun Lee; Lu Liu; Shou-wu Ma; Peg Davis; Victor J Hruby
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Bioorganic & medicinal chemistry letters 2013;23(11):3434-7.
2013: Alysia N Lozano-Ondoua; Patrick W Mantyh; Mark A Nelson; Tijana Nikolich-Zugich; Mabel Owusu-Ankomah; Frank Porreca; Ashley M Symons-Liguori; Aaron P Bloom; Anupama Chandramouli; Henry L Ferland; Katherine E Hanlon; Josh J Havelin; Juan Miguel Jimenez-Andrade; Tamara King; Tally M Largent-Milnes; Todd W Vanderah
Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(1):92-107.
2012: Rebecca Edelmayer; Pierangelo Geppetti; Larry N Le; Serena Materazzi; Romina Nassini; Frank Porreca; Delia Preti; Todd W Vanderah; Xiaomei Wei; Jin Yan; Giovanni Appendino; David W Dodick; G Dussor
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain.
Pain 2012;153(9):1949-58.
2012: Milena De Felice; Pietro Melchiorri; Michael H Ossipov; Frank Porreca; Todd W Vanderah; Lucia Negri
Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression.
Neuroscience letters 2012;521(1):40-5.
2012: Hassan Pajouhesh; Hossein Pajouhesh; Frank Porreca; Francesco Belardetti; Yanbing Ding; Haiheng Dong; Zhong-Ping Feng; Adam Hendricson; Xinpo Jiang; Lester A Mitscher; Elizabeth Tringham; Todd W Vanderah; Gerald W Zamponi; Lingyun Zhang; Terrance P Snutch
Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(12):4153-8.
2012: Suneeta Tumati; Todd W Vanderah; Takashi Yamamoto; Victor J Hruby; Attila I Keresztes; Tally M Largent-Milnes; William R Roeske; Eva V Varga
Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation.
European journal of pharmacology 2012;684(1-3):64-70.
2012: Suneeta Tumati; Todd W Vanderah; Attila Keresztes; Tally M Largent-Milnes; Jiyang Ren; William R Roeske; Eva V Varga
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.
Journal of neuroimmunology 2012;244(1-2):23-31.
2011: Milena De Felice; G Dussor; Howard L Fields; Tamara King; Josephine Lai; Michael H Ossipov; Janice Oyarzo; Theodore Price; Raul Sanoja; Todd W Vanderah; Louis Vera-Portocarrero; Ruizhong Wang; Frank Porreca
Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain.
Pain 2011;152(12):2701-9.
2011: Ruben Vardanyan; Eva Varga; Peg Davis; Vlad K Kumirov; Josephine Lai; Erika Liktor-Busa; Gary S Nichol; Frank Porreca; David Rankin; Todd W Vanderah; Victor J Hruby
Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.
Bioorganic & medicinal chemistry 2011;19(20):6135-42.
2011: Beatriz Fioravanti; Edward D French; Jed A Hartings; Aimen Kasasbeh; Frank Porreca; David P Skinner; Ryan D Burklund; Milena De Felice; David W Dodick; G Dussor; Rebecca Edelmayer; Todd W Vanderah
Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats.
Cephalalgia : an international journal of headache 2011;31(10):1090-100.
2011: Katherine E Hanlon; Dave S Herman; Richard S Agnes; Tally M Largent-Milnes; Isuru R Kumarasinghe; Shou-wu Ma; Wenhong Guo; Yeon-Sun Lee; Michael H Ossipov; Victor J Hruby; Josephine Lai; Frank Porreca; Todd W Vanderah
Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain.
Brain research 2011;1395():1-11.
2011: Takashi Yamamoto; Padma Nair; Tally M Largent-Milnes; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Journal of medicinal chemistry 2011;54(7):2029-38.
2011: Nicola J Stagg; Heriberto P Mata; Mohab M Ibrahim; Erik J Henriksen; Frank Porreca; Todd W Vanderah; T Philip Malan
Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids.
Anesthesiology 2011;114(4):940-8.
2011: Yeon Sun Lee; Shou-wu Ma; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Scott M Cowell; Peg Davis; Katherine E Hanlon; Vinod Kulkarani; Josephine Lai; Victor J Hruby
Development of potent μ and δ opioid agonists with high lipophilicity.
Journal of medicinal chemistry 2011;54(1):382-6.
2011: Devki Sukhtankar; Todd W Vanderah; Anupama Chandramouli; Anne E Cress; Mark A Nelson; Alec Okun; Frank Porreca; Tamara King
Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.
Molecular pain 2011;7():81.
2010: Suneeta Tumati; William R Roeske; Todd W Vanderah; Eva V Varga
Sustained morphine treatment augments prostaglandin E2-evoked calcitonin gene-related peptide release from primary sensory neurons in a PKA-dependent manner.
European journal of pharmacology 2010;648(1-3):95-101.
2010: S Tumati; William R Roeske; T Largent-Milnes; R Wang; Todd W Vanderah; Eva V Varga
Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA.
British journal of pharmacology 2010;161(1):51-64.
2010: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Vinod Kulkarni; Peg Davis; Shou-Wu Ma; Edita Navratilova; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.
Journal of medicinal chemistry 2010;53(15):5491-501.
2010: Alysia N Lozano-Ondoua; Courtney Wright; Anna Vardanyan; Tamara King; Tally M Largent-Milnes; Mark Nelson; Juan Miguel Jimenez-Andrade; Patrick W Mantyh; Todd W Vanderah
A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss.
Life sciences 2010;86(17-18):646-53.
2010: Milena De Felice; Michael H Ossipov; Ruizhong Wang; Josephine Lai; Juliana Chichorro; Ian Meng; David W Dodick; Todd W Vanderah; G Dussor; Frank Porreca
Triptan-induced latent sensitization: a possible basis for medication overuse headache.
Annals of neurology 2010;67(3):325-37.
2010: Tally M Largent-Milnes; Todd W Vanderah
Recently patented and promising ORL-1 ligands: where have we been and where are we going?
Expert opinion on therapeutic patents 2010;20(3):291-305.
2010: Hassan Pajouhesh; Zhong-Ping Feng; Yanbing Ding; Lingyun Zhang; Hossein Pajouhesh; Jerrie-Lynn Morrison; Francesco Belardetti; Elizabeth Tringham; Eric Simonson; Todd W Vanderah; Frank Porreca; Gerald W Zamponi; Lester A Mitscher; Terrance P Snutch
Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(4):1378-83.
2010: Juan Miguel Jimenez-Andrade; William G Mantyh; Aaron P Bloom; Haili Xu; Alice S Ferng; G Dussor; Todd W Vanderah; Patrick W Mantyh
A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain.
Bone 2010;46(2):306-13.
2010: Katherine E Hanlon; Todd W Vanderah
Constitutive activity at the cannabinoid CB(1) receptor and behavioral responses.
Methods in enzymology 2010;484():3-30.
2010: Todd W Vanderah
Delta and kappa opioid receptors as suitable drug targets for pain.
The Clinical journal of pain 2010;26 Suppl 10():S10-5.
2009: Tamara King; Louis Vera-Portocarrero; Tannia Gutierrez; Todd W Vanderah; G Dussor; Josephine Lai; Howard Fields; Frank Porreca
Unmasking the tonic-aversive state in neuropathic pain.
Nature neuroscience 2009;12(11):1364-6.
2009: Takashi Yamamoto; Padma Nair; Shou-wu Ma; Peg Davis; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Bioorganic & medicinal chemistry 2009;17(20):7337-43.
2009: Suneeta Tumati; Henry I Yamamura; Todd W Vanderah; William R Roeske; Eva V Varga
Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner.
The Journal of pharmacology and experimental therapeutics 2009;330(3):810-7.
2009: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Josef Vagner; Vinod Kulkarni; Peg Davis; Shou-wu Ma; Edita Navratilova; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2009;52(16):5164-75.
2009: Ruben Vardanyan; Gokhale Vijay; Gary S Nichol; Lu Liu; Isuru Kumarasinghe; Peg Davis; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.
Bioorganic & medicinal chemistry 2009;17(14):5044-53.
2009: Suneeta Tumati; Henry I Yamamura; Paul S. St. John; Todd W Vanderah; William R Roeske; Eva V Varga
Sustained cannabinoid agonist treatment augments CGRP release in a PKA-dependent manner.
Neuroreport 2009;20(8):815-9.
2009: Frank Porreca; Todd W Vanderah
Spring pain research conference 2008.
Brain research reviews 2009;60(1):1.
2009: Christoph Stein; J David Clark; Uhtaek Oh; Michael R Vasko; George L Wilcox; Aaron C Overland; Todd W Vanderah; Robert H Spencer
Peripheral mechanisms of pain and analgesia.
Brain research reviews 2009;60(1):90-113.
2009: Wenjun Zhang; Shannon Gardell; Dongqin Zhang; Jennifer Y Xie; Richard S Agnes; Hamid Badghisi; Victor J Hruby; Naomi Rance; Michael H Ossipov; Todd W Vanderah; Frank Porreca; Josephine Lai
Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors.
Brain : a journal of neurology 2009;132(Pt 3):778-87.
2009: Anna Vardanyan; Ruizhong Wang; Todd W Vanderah; Michael H Ossipov; Josephine Lai; Frank Porreca; Tamara King
TRPV1 receptor in expression of opioid-induced hyperalgesia.
The journal of pain : official journal of the American Pain Society 2009;10(3):243-52.
2009: Rebecca Edelmayer; Todd W Vanderah; Lisa Majuta; En-Tan Zhang; Beatriz Fioravanti; Milena De Felice; Juliana G Chichorro; Michael H Ossipov; Tamara King; Josephine Lai; Shashi H Kori; Andrew C Nelsen; Keri E Cannon; Mary M Heinricher; Frank Porreca
Medullary pain facilitating neurons mediate allodynia in headache-related pain.
Annals of neurology 2009;65(2):184-93.
2009: Padma Nair; Takashi Yamamoto; Vinod Kulkarni; Sharif Moye; Edita Navratilova; Peg Davis; Tally Largent; Shou-wu Ma; Henry I Yamamura; Todd W Vanderah; Josephine Lai; Frank Porreca; Victor J Hruby
Novel bifunctional peptides as opioid agonists and NK-1 antagonists.
Advances in experimental medicine and biology 2009;611():537-8.
2009: YeonSun Lee; Ravil Petrov; Vinod Kulkarni; Byoung J Min; Shou-wu Ma; Peg Davis; Janice Oyarzo; Todd W Vanderah; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety.
Advances in experimental medicine and biology 2009;611():517-8.
2008: Suneeta Tumati; Tally Largent Milnes; Henry I Yamamura; Todd W Vanderah; William R Roeske; Eva V Varga
Intrathecal Raf-1-selective siRNA attenuates sustained morphine-mediated thermal hyperalgesia.
European journal of pharmacology 2008;601(1-3):207-8.
2008: Beatriz Fioravanti; Milena De Felice; Cheryl L Stucky; Karen A Medler; Miaw-Chyi Luo; Luis R Gardell; mukwaya Ibrahim; T Philip Malan; Henry I Yamamura; Michael H Ossipov; Tamara King; Josephine Lai; Frank Porreca; Todd W Vanderah
Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(45):11593-602.
2008: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Josephine Lai; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Victor J Hruby
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(20):6334-47.
2008: Tally M Largent-Milnes; Wenhong Guo; Hoau-Yan Wang; Lindsay H Burns; Todd W Vanderah
Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling.
The journal of pain : official journal of the American Pain Society 2008;9(8):700-13.
2008: Xu Yue; Suneeta Tumati; Edita Navratilova; Dagmar Strop; Paul S. St. John; Todd W Vanderah; William R Roeske; Henry I Yamamura; Eva V Varga
Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner.
European journal of pharmacology 2008;584(2-3):272-7.
2008: Ruizhong Wang; Tamara King; Michael H Ossipov; Anthony J Rossomando; Todd W Vanderah; Pamela Harvey; Peter Cariani; Eric Frank; Dinah W Y Sah; Frank Porreca
Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury.
Nature neuroscience 2008;11(4):488-96.
2008: Todd W Vanderah; Tally Largent-Milnes; Josephine Lai; Frank Porreca; Richard A Houghten; Frédérique Menzaghi; Kazimierz Wisniewski; Jacek Stalewski; Javier Sueiras-Diaz; Robert Galyean; Claudio D Schteingart; Jean-Louis Junien; Jerzy Trojnar; PJ Rivière
Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors.
European journal of pharmacology 2008;583(1):62-72.
2008: Takashi Yamamoto; Padma Nair; Josef Vagner; Tally Largent-Milnes; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Suneeta Tumati; Josephine Lai; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Victor J Hruby
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(5):1369-76.
2008: Beatriz Fioravanti; Todd W Vanderah
The ORL-1 receptor system: are there opportunities for antagonists in pain therapy?
Current topics in medicinal chemistry 2008;8(16):1442-51.
2007: Tamara King; Anna Vardanyan; Lisa Majuta; Ohannes Melemedjian; Raymond B Nagle; Anne E Cress; Todd W Vanderah; Josephine Lai; Frank Porreca
Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer.
Pain 2007;132(1-2):154-68.
2007: Takashi Yamamoto; Padma Nair; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Suneeta Tumati; Josephine Lai; Todd W Vanderah; Henry I Yamamura; Frank Porreca; Victor J Hruby
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Journal of medicinal chemistry 2007;50(12):2779-86.
2007: Louis P Vera-Portocarrero; En-Tan Zhang; Tamara King; Michael H Ossipov; Todd W Vanderah; Josephine Lai; Frank Porreca
Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.
Pain 2007;129(1-2):35-45.
2007: Stephen H King; Alexander V Mayorov; Preeti Balse-Srinivasan; Victor J Hruby; Todd W Vanderah; Hunter Wessells
Melanocortin receptors, melanotropic peptides and penile erection.
Current topics in medicinal chemistry 2007;7(11):1098-1106.
2007: Todd W Vanderah
Pathophysiology of pain.
The Medical clinics of North America 2007;91(1):1-12.
2006: Tamara King; Srinivas Rao; Todd W Vanderah; Qingmin Chen; Anna Vardanyan; Frank Porreca
Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran.
The journal of pain : official journal of the American Pain Society 2006;7(7):513-20.
2006: Xu Yue; Eva V Varga; Dagmar Stropova; Todd W Vanderah; Henry I Yamamura; William R Roeske
Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor, GW5074.
European journal of pharmacology 2006;540(1-3):57-9.
2006: Frank Porreca; Todd W Vanderah; W Guo; M Barth; PR Dodey; V Peyrou; Jean-Michel Luccarini; Jean-Louis Junien; Didier Pruneau
Antinociceptive pharmacology of N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl) sulfonyl]methylamino]ethoxy]-N-methylacetamide, fumarate (LF22-0542), a novel nonpeptidic bradykinin B1 receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2006;318(1):195-205.
2006: Mohab M Ibrahim; Megan L Rude; Nicola J Stagg; Heriberto P Mata; Josephine Lai; Todd W Vanderah; Frank Porreca; Nancy E Buckley; Alexandros Makriyannis; T Philip Malan
CB2 cannabinoid receptor mediation of antinociception.
Pain 2006;122(1-2):36-42.
2006: Luis R Gardell; Tamara King; Michael H Ossipov; Kenner C Rice; Josephine Lai; Todd W Vanderah; Frank Porreca
Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery.
Neuroscience letters 2006;396(1):44-9.
2006: Victor J Hruby; Frank Porreca; Henry I Yamamura; Gordon Tollin; Richard S Agnes; Yeon Sun Lee; Minying Cai; Isabel D Alves; Scott M Cowell; Eva Varga; Peg Davis; Zdzislaw Salamon; William R Roeske; Todd W Vanderah; Josephine Lai
New paradigms and tools in drug design for pain and addiction.
The AAPS journal 2006;8(3):E450-60.
2005: Hunter Wessells; James E Blevins; Todd W Vanderah
Melanocortinergic control of penile erection.
Peptides 2005;26(10):1972-7.
2005: Edita Navratilova; Miriam C Eaton; Dagmar Stropova; Eva V Varga; Todd W Vanderah; William R Roeske; Henry I Yamamura
Morphine promotes phosphorylation of the human delta-opioid receptor at serine 363.
European journal of pharmacology 2005;519(3):212-4.
2005: Tamara King; Luis R Gardell; Ruizhong Wang; Anna Vardanyan; Michael H Ossipov; T Philip Malan; Todd W Vanderah; Stephen P Hunt; Victor J Hruby; Josephine Lai; Frank Porreca
Role of NK-1 neurotransmission in opioid-induced hyperalgesia.
Pain 2005;116(3):276-88.
2005: Narender R Gavva; Rami Tamir; Yusheng Qu; Lana Klionsky; Tie J Zhang; David C Immke; Judy Wang; Dawn Zhu; Todd W Vanderah; Frank Porreca; Elizabeth M Doherty; Mark H Norman; Kenneth D Wild; Anthony W Bannon; Jean-Claude Louis; James J S Treanor
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.
The Journal of pharmacology and experimental therapeutics 2005;313(1):474-84.
2005: Mohab M Ibrahim; Frank Porreca; Josephine Lai; Phillip J Albrecht; Frank rice; Alla Khodorova; Gudarz Davar; Alexandros Makriyannis; Todd W Vanderah; Heriberto P Mata; T Philip Malan
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3093-8.
2005: Eva V Varga; Keiko Hosohata; Dariusz Borys; Edita Navratilova; Anders Nylen; Todd W Vanderah; Frank Porreca; William R Roeske; Henry I Yamamura
Antinociception depends on the presence of G protein gamma2-subunits in brain.
European journal of pharmacology 2005;508(1-3):93-8.
2005: Jennifer Y Xie; David Herman; Carl-Olav Stiller; Luis R Gardell; Michael H Ossipov; Josephine Lai; Frank Porreca; Todd W Vanderah
Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(2):409-16.
2005: Tamara King; Michael H Ossipov; Todd W Vanderah; Frank Porreca; Josephine Lai
Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?
Neuro-Signals 2005;14(4):194-205.
2005: Michael H Ossipov; Josephine Lai; Tamara King; Todd W Vanderah; Frank Porreca
Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure.
Biopolymers 2005;80(2-3):319-24.
2004: Michael H Ossipov; Josephine Lai; Tamara King; Todd W Vanderah; T Philip Malan; Victor J Hruby; Frank Porreca
Antinociceptive and nociceptive actions of opioids.
Journal of neurobiology 2004;61(1):126-48.
2004: Todd W Vanderah; Claudio D Schteingart; Jerzy Trojnar; Jean-Louis Junien; Josephine Lai; Pierre J-M Riviere
FE200041 (D-Phe-D-Phe-D-Nle-D-Arg-NH2): A peripheral efficacious kappa opioid agonist with unprecedented selectivity.
The Journal of pharmacology and experimental therapeutics 2004;310(1):326-33.
2004: Qingmin Chen; Tamara King; Todd W Vanderah; Michael H Ossipov; T Philip Malan; Josephine Lai; Frank Porreca
Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics.
The journal of pain : official journal of the American Pain Society 2004;5(5):281-9.
2004: Aline Quartilho; Heriberto P Mata; Mohab M Ibrahim; Todd W Vanderah; Michael H Ossipov; Josephine Lai; Frank Porreca; T Philip Malan
Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists.
Anesthesiology 2004;100(6):1538-44.
2004: Narender R Gavva; Lana Klionsky; Yusheng Qu; Licheng Shi; Rami Tamir; Steve Edenson; Tie J Zhang; Vellarkad Viswanadhan; Attila Toth; Larry V Pearce; Todd W Vanderah; Frank Porreca; Peter M Blumberg; Jack Lile; Yax Sun; Kenneth D Wild; Jean-Claude Louis; James J S Treanor
Molecular determinants of vanilloid sensitivity in TRPV1.
The Journal of biological chemistry 2004;279(19):20283-95.
2004: Robert P Yezierski; Ellyn Radson; Todd W Vanderah
Understanding chronic pain.
Nursing 2004;34(4):22-3.
2003: Luis R Gardell; Ruizhong Wang; Chris Ehrenfels; Michael H Ossipov; Anthony J Rossomando; Stephan Miller; Carolyn Buckley; Amber K Cai; Albert Tse; Susan F Foley; BangJian Gong; Lee Walus; Paul Carmillo; Dane Worley; Carol Huang; Thomas Engber; Blake Pepinsky; Richard L Cate; Todd W Vanderah; Josephine Lai; Dinah W Y Sah; Frank Porreca
Multiple actions of systemic artemin in experimental neuropathy.
Nature medicine 2003;9(11):1383-9.
2003: Aline Quartilho; Heriberto P Mata; Mohab M Ibrahim; Todd W Vanderah; Frank Porreca; Alexandros Makriyannis; T Philip Malan
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors.
Anesthesiology 2003;99(4):955-60.
2003: Luis R Gardell; Todd W Vanderah; S E Gardell; Ruizhong Wang; Michael H Ossipov; Josephine Lai; Frank Porreca
Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(23):8370-9.
2003: Mohab M Ibrahim; Hongfeng Deng; Alexander Zvonok; Debra A Cockayne; Joyce Kwan; Heriberto P Mata; Todd W Vanderah; Josephine Lai; Frank Porreca; Alexandros Makriyannis; T Philip Malan
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10529-33.
2003: Michael H Ossipov; Josephine Lai; Todd W Vanderah; Frank Porreca
Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance.
Life sciences 2003;73(6):783-800.
2003: Victor J Hruby; Richard S Agnes; Peg Davis; Shou-wu Ma; Yeon Sun Lee; Todd W Vanderah; Josephine Lai; Frank Porreca
Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain.
Life sciences 2003;73(6):699-704.
2003: Hunter Wessells; Victor J Hruby; John Hackett; Guoxia Han; Preeti Balse-Srinivasan; Todd W Vanderah
MT-II induces penile erection via brain and spinal mechanisms.
Annals of the New York Academy of Sciences 2003;994():90-5.
2003: T Philip Malan; Mohab M Ibrahim; Josephine Lai; Todd W Vanderah; Alexandros Makriyannis; Frank Porreca
CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?
Current opinion in pharmacology 2003;3(1):62-7.
2003: Keiko Hosohata; Eva V Varga; Josue Alfaro-Lopez; Xuejun Tang; Todd W Vanderah; Frank Porreca; Victor J Hruby; William R Roeske; Henry I Yamamura
(2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain.
The Journal of pharmacology and experimental therapeutics 2003;304(2):683-8.
2003: Ruizhong Wang; W Guo; Michael H Ossipov; Todd W Vanderah; Frank Porreca; Josephine Lai
Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain.
Neuroscience 2003;121(3):815-24.
2003: Hunter Wessells; Victor J Hruby; J Hackett; Guoxia Han; Preeti Balse-Srinivasan; Todd W Vanderah
Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors.
Neuroscience 2003;118(3):755-62.
2002: T Philip Malan; Mohab M Ibrahim; Todd W Vanderah; Alexandros Makriyannis; Frank Porreca
Inhibition of pain responses by activation of CB(2) cannabinoid receptors.
Chemistry and physics of lipids 2002;121(1-2):191-200.
2002: Luis R Gardell; Michael H Ossipov; Todd W Vanderah; Josephine Lai; Frank Porreca
Dynorphin-independent spinal cannabinoid antinociception.
Pain 2002;100(3):243-8.
2002: Luis R Gardell; Ruizhong Wang; Shannon E Burgess; Michael H Ossipov; Todd W Vanderah; T Philip Malan; Josephine Lai; Frank Porreca
Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(15):6747-55.
2002: Shannon E Burgess; Luis R Gardell; Michael H Ossipov; T Philip Malan; Todd W Vanderah; Josephine Lai; Frank Porreca
Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(12):5129-36.
2001: T Philip Malan; Mohab M Ibrahim; Hongfeng Deng; Q Liu; Heriberto P Mata; Todd W Vanderah; Frank Porreca; Alexandros Makriyannis
CB2 cannabinoid receptor-mediated peripheral antinociception.
Pain 2001;93(3):239-45.
2001: Josephine Lai; Michael H Ossipov; Todd W Vanderah; T Philip Malan; Frank Porreca
Neuropathic pain: the paradox of dynorphin.
Molecular interventions 2001;1(3):160-7.
2001: Frank Porreca; Shannon E Burgess; Luis R Gardell; Todd W Vanderah; T Philip Malan; Michael H Ossipov; D A Lappi; Josephine Lai
Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(14):5281-8.
2001: I I Simoneau; M S Hamza; Heriberto P Mata; Erin M Siegel; Todd W Vanderah; Frank Porreca; Alexandros Makriyannis; T Philip Malan
The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets.
Anesthesiology 2001;94(5):882-7.
2001: Todd W Vanderah; Michael H Ossipov; Josephine Lai; T Philip Malan; Frank Porreca
Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin.
Pain 2001;92(1-2):5-9.
2001: Zaijie Jim Wang; Luis R Gardell; Michael H Ossipov; Todd W Vanderah; Miles B Brennan; Ute Hochgeschwender; Victor J Hruby; T Philip Malan; Josephine Lai; Frank Porreca
Pronociceptive actions of dynorphin maintain chronic neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(5):1779-86.
2001: Todd W Vanderah; N M Suenaga; Michael H Ossipov; T Philip Malan; Josephine Lai; Frank Porreca
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(1):279-86.
2000: Todd W Vanderah; Luis R Gardell; Shannon E Burgess; mukwaya Ibrahim; Ahmet Dogrul; C M Zhong; En-Tan Zhang; T Philip Malan; Michael H Ossipov; Josephine Lai; Frank Porreca
Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):7074-9.
2000: Keiko Hosohata; J K Logan; Eva Varga; TH Burkey; Todd W Vanderah; Frank Porreca; Victor J Hruby; William R Roeske; Henry I Yamamura
The role of the G protein gamma(2) subunit in opioid antinociception in mice.
European journal of pharmacology 2000;392(3):R9-R11.
2000: Yoshiaki Hosohata; Todd W Vanderah; TH Burkey; Michael H Ossipov; CJ Kovelowski; I Sora; George R. Uhl; X Zhang; Kenner C Rice; William R Roeske; Victor J Hruby; Henry I Yamamura; Josephine Lai; Frank Porreca
delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice.
European journal of pharmacology 2000;388(3):241-8.
1998: Todd W Vanderah; Robert Raffa; JM Lashbrook; A Burritt; Victor J Hruby; Frank Porreca
Orphanin-FQ/nociceptin: lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats.
European journal of pain (London, England) 1998;2(3):267-78.
1997: Tinna M Laughlin; Todd W Vanderah; JM Lashbrook; ML Nichols; Michael H Ossipov; Frank Porreca; George L Wilcox
Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors.
Pain 1997;72(1-2):253-60.
1997: S Wegert; Michael H Ossipov; ML Nichols; Di Bian; Todd W Vanderah; T Philip Malan; Frank Porreca
Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats.
Pain 1997;71(1):57-64.
1996: Todd W Vanderah; Tinna M Laughlin; J M Lashbrook; ML Nichols; George L Wilcox; Michael H Ossipov; T Philip Malan; F Porreca
Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone.
Pain 1996;68(2-3):275-81.
1996: Todd W Vanderah; R N Bernstein; Henry I Yamamura; Victor J Hruby; F Porreca
Enhancement of morphine antinociception by a CCKB antagonist in mice is mediated via opioid delta receptors.
The Journal of pharmacology and experimental therapeutics 1996;278(1):212-9.
1996: S A Edsall; Richard J Knapp; Todd W Vanderah; William R Roeske; P Consroe; Henry I Yamamura
Antisense oligodeoxynucleotide treatment to the brain cannabinoid receptor inhibits antinociception.
Neuroreport 1996;7(2):593-6.
1996: P A Zaki; E J Bilsky; Todd W Vanderah; Josephine Lai; Christopher J Evans; F Porreca
Opioid receptor types and subtypes: the delta receptor as a model.
Annual review of pharmacology and toxicology 1996;36():379-401.
1994: Todd W Vanderah; Josephine Lai; Henry I Yamamura; F Porreca
Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception.
Neuroreport 1994;5(18):2601-5.
1994: Michael H Ossipov; CJ Kovelowski; Todd W Vanderah; F Porreca
Naltrindole, an opioid delta antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat.
Neuroscience letters 1994;181(1-2):9-12.
1994: I Sora; Jeremy G Richman; G Santoro; Hongbing Wei; Y Wang; Todd W Vanderah; R Horvath; M Nguyen; Sue Waite; William R Roeske
The cloning and expression of a human creatine transporter.
Biochemical and biophysical research communications 1994;204(1):419-27.
1994: Todd W Vanderah; A E Takemori; M Sultana; P S Portoghese; Henry I Mosberg; Victor J Hruby; R C Haaseth; T O Matsunaga; F Porreca
Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo.
European journal of pharmacology 1994;252(2):133-7.
1993: K D Wild; J McCormick; E J Bilsky; Todd W Vanderah; R W McNutt; K J Chang; F Porreca
Antinociceptive actions of BW373U86 in the mouse.
The Journal of pharmacology and experimental therapeutics 1993;267(2):858-65.
1993: Todd W Vanderah; K D Wild; A E Takemori; M Sultana; P S Portoghese; W D Bowen; Victor J Hruby; Henry I Mosberg; F Porreca
Modulation of morphine antinociception by swim-stress in the mouse: involvement of supraspinal opioid delta-2 receptors.
The Journal of pharmacology and experimental therapeutics 1993;267(1):449-55.
1992: Todd W Vanderah; K D Wild; A E Takemori; M Sultana; P S Portoghese; W D Bowen; Henry I Mosberg; F Porreca
Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse.
The Journal of pharmacology and experimental therapeutics 1992;262(1):190-7.
1991: A Mattia; Todd W Vanderah; Henry I Mosberg; F Porreca
Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes.
The Journal of pharmacology and experimental therapeutics 1991;258(2):583-7.
1991: K D Wild; Todd W Vanderah; Henry I Mosberg; F Porreca
Opioid delta receptor subtypes are associated with different potassium channels.
European journal of pharmacology 1991;193(1):135-6.
1991: A Mattia; Todd W Vanderah; Henry I Mosberg; J R Omnaas; W D Bowen; F Porreca
Pharmacological characterization of [D-Ala2,Leu5,Ser6]enkephalin (DALES): antinociceptive actions at the delta non-complexed-opioid receptor.
European journal of pharmacology 1991;192(3):371-5.