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Patrick Vanderheyden

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.8 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Anatomy

CHO Cells

Living Beings

Physiology

Procedures

Radioligand Assay

Concepts & Ideas

Drug Dose-Response Relationship

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Co-Publications
Name
59
Vauquelin, Georges
32
De Backer, Jean-Paul
14
Fierens, Frederik
12
Demaegdt, Heidi
12
Michotte, Yvette
11
Le, Minh Tam
8
Verheijen, Ilse
7
Van Liefde, Isabelle
7
Smolders, Ilse
7
Ebinger, Guy
5
Caballero-George, Catherina
5
Pieters, Luc
5
Gupta, Mahabir
5
Hunyady, László
5
Sarre, Sophie

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Publications

TOP 3
De Bundel Dimitri; Demaegdt Heidi; Lahoutte Tony; Caveliers Vicky; Kersemans Ken; Ceulemans Ann-Gaelle; Vauquelin Georges; Clinckers Ralph; Vanderheyden Patrick; Michotte Yvette; Smolders Ilse
Involvement of the AT1 receptor subtype in the effects of angiotensin IV and LVV-haemorphin 7 on hippocampal neurotransmitter levels and spatial working memory.
Yang Rui; Walther Thomas; Gembardt Florian; Smolders Ilse; Vanderheyden Patrick; Albiston Anthony L; Chai Siew Yeen; Dupont Alain G
Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated.
Mertens Birgit; Vanderheyden Patrick; Michotte Yvette; Sarre Sophie
The role of the central renin-angiotensin system in Parkinson's disease.

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All Publications

2010: De Bundel Dimitri; Demaegdt Heidi; Lahoutte Tony; Caveliers Vicky; Kersemans Ken; Ceulemans Ann-Gaelle; Vauquelin Georges; Clinckers Ralph; Vanderheyden Patrick; Michotte Yvette; Smolders Ilse
Involvement of the AT1 receptor subtype in the effects of angiotensin IV and LVV-haemorphin 7 on hippocampal neurotransmitter levels and spatial working memory.
Journal of neurochemistry 2010;112(5):1223-34.
2010: Yang Rui; Walther Thomas; Gembardt Florian; Smolders Ilse; Vanderheyden Patrick; Albiston Anthony L; Chai Siew Yeen; Dupont Alain G
Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated.
Journal of hypertension 2010;28(3):487-94.
2010: Mertens Birgit; Vanderheyden Patrick; Michotte Yvette; Sarre Sophie
The role of the central renin-angiotensin system in Parkinson's disease.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2010;11(1):49-56.
2009: Lukaszuk Aneta; Demaegdt Heidi; Feytens Debby; Vanderheyden Patrick; Vauquelin Georges; Tourwé Dirk
The replacement of His(4) in angiotensin IV by conformationally constrained residues provides highly potent and selective analogues.
Journal of medicinal chemistry 2009;52(18):5612-8.
2009: Vanderheyden Patrick M L
From angiotensin IV binding site to AT4 receptor.
Molecular and cellular endocrinology 2009;302(2):159-66.
2008: Stragier Bart; De Bundel Dimitri; Sarre Sophie; Smolders Ilse; Vauquelin Georges; Dupont Alain; Michotte Yvette; Vanderheyden Patrick
Involvement of insulin-regulated aminopeptidase in the effects of the renin-angiotensin fragment angiotensin IV: a review.
Heart failure reviews 2008;13(3):321-37.
2008: Demaegdt H; Smitz L; De Backer J-P; Le M T; Bauwens M; Szemenyei E; Tóth G; Michotte Y; Vanderheyden P; Vauquelin G
Translocation of the insulin-regulated aminopeptidase to the cell surface: detection by radioligand binding.
British journal of pharmacology 2008;154(4):872-81.
2008: Packeu Ann; De Backer Jean-Paul; Van Liefde Isabelle; Vanderheyden Patrick M L; Vauquelin Georges
Antagonist-radioligand binding to D2L-receptors in intact cells.
Biochemical pharmacology 2008;75(11):2192-203.
2008: Yang Rui; Smolders Ilse; De Bundel Dimitri; Fouyn Renaud; Halberg Mathias; Demaegdt Heidi; Vanderheyden Patrick; Dupont Alain G
Brain and peripheral angiotensin II type 1 receptors mediate renal vasoconstrictor and blood pressure responses to angiotensin IV in the rat.
Journal of hypertension 2008;26(5):998-1007.
2008: Lukaszuk Aneta; Demaegdt Heidi; Szemenyei Erzsebet; Tóth Géza; Tymecka Dagmara; Misicka Aleksandra; Karoyan Philippe; Vanderheyden Patrick; Vauquelin Georges; Tourwé Dirk
Beta-homo-amino acid scan of angiotensin IV.
Journal of medicinal chemistry 2008;51(7):2291-6.
2008: De Bundel Dimitri; Smolders Ilse; Vanderheyden Patrick; Michotte Yvette
Ang II and Ang IV: unraveling the mechanism of action on synaptic plasticity, memory, and epilepsy.
CNS neuroscience & therapeutics 2008;14(4):315-39.
2007: Lamanna Claudia; Catalano Alessia; Carocci Alessia; Di Mola Antonia; Franchini Carlo; Tortorella Vincenzo; Vanderheyden Patrick M L; Sinicropi Maria S; Watson Kimberly A; Sciabola Simone
AT1 receptor ligands: virtual-screening-based design with TOPP descriptors, synthesis, and biological evaluation of pyrrolidine derivatives.
ChemMedChem 2007;2(9):1298-310.
2007: Stragier Bart; Demaegdt Heidi; De Bundel Dimitri; Smolders Ilse; Sarre Sophie; Vauquelin Georges; Ebinger Guy; Michotte Yvette; Vanderheyden Patrick
Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat.
Brain research 2007;1131(1):97-105.
2006: Vanderheyden Patrick M L; Demaegdt Heidi; Swales Julie; Lenaerts Pieter-Jan; De Backer Jean-Paul; Vogel Lotte K; Vauquelin Georges
Synergistic inhibition of the enzymatic activity of aminopeptidase N by divalent metal ion chelators.
Fundamental & clinical pharmacology 2006;20(6):613-9.
2006: Demaegdt Heidi; Lenaerts Pieter-Jan; Swales Julie; De Backer Jean-Paul; Laeremans Hilde; Le Minh Tam; Kersemans Ken; Vogel Lotte K; Michotte Yvette; Vanderheyden Patrick; Vauquelin Georges
Angiotensin AT4 receptor ligand interaction with cystinyl aminopeptidase and aminopeptidase N: [125I]Angiotensin IV only binds to the cystinyl aminopeptidase apo-enzyme.
European journal of pharmacology 2006;546(1-3):19-27.
2005: Laeremans Hilde; Demaegdt Heidi; De Backer Jean-Paul; Le Minh T; Kersemans Veerle; Michotte Yvette; Vauquelin Georges; Vanderheyden Patrick M L
Metal ion modulation of cystinyl aminopeptidase.
The Biochemical journal 2005;390(Pt 1):351-7.
2005: Esteban Vanesa; Ruperez Mónica; Sánchez-López Elsa; Rodríguez-Vita Juan; Lorenzo Oscar; Demaegdt Heidi; Vanderheyden Patrick; Egido Jesús; Ruiz-Ortega Marta
Angiotensin IV activates the nuclear transcription factor-kappaB and related proinflammatory genes in vascular smooth muscle cells.
Circulation research 2005;96(9):965-73.
2005: Le Minh Tam; De Backer Jean-Paul; Hunyady László; Vanderheyden Patrick M L; Vauquelin Georges
Ligand binding and functional properties of human angiotensin AT1 receptors in transiently and stably expressed CHO-K1 cells.
European journal of pharmacology 2005;513(1-2):35-45.
2004: Caballero-George C; Vanderheyden P M L; Okamoto Y; Masaki T; Mbwambo Z; Apers S; Gupta M P; Pieters L; Vauquelin G; Vlietinck A
Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors.
Phytotherapy research : PTR 2004;18(9):729-36.
2004: Stragier Bart; Sarre Sophie; Vanderheyden Patrick; Vauquelin Georges; Fournié-Zaluski Marie-Claude; Ebinger Guy; Michotte Yvette
Metabolism of angiotensin II is required for its in vivo effect on dopamine release in the striatum of the rat.
Journal of neurochemistry 2004;90(5):1251-7.
2004: Demaegdt Heidi; Laeremans Hilde; De Backer Jean-Paul; Mosselmans Sabrina; Le Minh Tam; Kersemans Veerle; Michotte Yvette; Vauquelin Georges; Vanderheyden Patrick M L
Synergistic modulation of cystinyl aminopeptidase by divalent cation chelators.
Biochemical pharmacology 2004;68(5):893-900.
2004: Demaegdt Heidi; Vanderheyden Patrick; De Backer Jean-Paul; Mosselmans Sabrina; Laeremans Hilde; Le Minh Tam; Kersemans Veerle; Michotte Yvette; Vauquelin Georges
Endogenous cystinyl aminopeptidase in Chinese hamster ovary cells: characterization by [125I]Ang IV binding and catalytic activity.
Biochemical pharmacology 2004;68(5):885-92.
2004: Verheijen Ilse; Tourlousse Dieter; Vanderheyden Patrick M L; Backer Jean-Paul De; Vauquelin Georges
Effect of saponin and filipin on antagonist binding to AT 1 receptors in intact cells.
Biochemical pharmacology 2004;67(8):1601-6.
2004: Verheijen I; Vanderheyden P M L; De Backer J P; Vauquelin G
AT1 receptor antagonists.
Current medicinal chemistry. Cardiovascular and hematological agents 2004;2(1):69-77.
2003: Le Minh Tam; Vanderheyden Patrick M L; Fierens Frederik L P; Vauquelin George
Molecular characterization of the high-affinity [3H]neuropeptide Y-binding component from the venom of Conus anemone.
Fundamental & clinical pharmacology 2003;17(4):457-62.
2003: Verheijen Ilse; De Backer Jean-Paul; Vanderheyden Patrick; Vauquelin Georges
A two-state model of antagonist-AT1 receptor interaction: further support by binding studies at low temperature.
Biochemical pharmacology 2003;65(8):1339-41.
2003: Le Minh Tam; Vanderheyden Patrick M L; Szaszák Márta; Hunyady László; Kersemans Veerle; Vauquelin Georges
Peptide and nonpeptide antagonist interaction with constitutively active human AT1 receptors.
Biochemical pharmacology 2003;65(8):1329-38.
2003: Hunyady László; Vauquelin Georges; Vanderheyden Patrick
Agonist induction and conformational selection during activation of a G-protein-coupled receptor.
Trends in pharmacological sciences 2003;24(2):81-6.
2003: Caballero-George Catherina; Vanderheyden Patrick M L; Solis Pablo N; Gupta Mahabir P; Pieters Luc; Vauquelin Georges; Vlietinck Arnold
In vitro effect of sanguinarine alkaloid on binding of [3H]candesartan to the human angiotensin AT1 receptor.
European journal of pharmacology 2003;458(3):257-62.
2002: Vauquelin Georges; Michotte Yvette; Smolders Ilse; Sarre Sophie; Ebinger Guy; Dupont Alain; Vanderheyden Patrick
Cellular targets for angiotensin II fragments: pharmacological and molecular evidence.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2002;3(4):195-204.
2002: Caballero-George Catherina; Vanderheyden Patrick M L; De Bruyne Tess; Shahat Abdel-Atty; Van den Heuvel Hilde; Solis Pablo N; Gupta Mahabir P; Claeys Magda; Pieters Luc; Vauquelin Georges; Vlietinck Arnold J
In vitro inhibition of [3H]-angiotensin II binding on the human AT1 receptor by proanthocyanidins from Guazuma ulmifolia bark.
Planta medica 2002;68(12):1066-71.
2002: Vauquelin Georges; Van Liefde Isabelle; Vanderheyden Patrick
Models and methods for studying insurmountable antagonism.
Trends in pharmacological sciences 2002;23(11):514-8.
2002: Verheijen Ilse; Vanderheyden Patrick M L; De Backer Jean-Paul; Bottari Serge; Vauquelin Georges
Antagonist interaction with endogenous AT(1) receptors in human cell lines.
Biochemical pharmacology 2002;64(8):1207-14.
2002: Caballero-George Catherina; Vanderheyden Patrick M L; Apers Sandra; Van den Heuvel Hilde; Solis Pablo N; Gupta Mahabir P; Claeys Magda; Pieters Luc; Vauquelin Georges; Vlietinck Arnold J
Inhibitory activity on binding of specific ligands to the human angiotensin II AT(1) and endothelin 1 ET(A) receptors: bioactive benzo[c]phenanthridine alkaloids from the root of Bocconia frutescens.
Planta medica 2002;68(9):770-5.
2002: Vauquelin G; Van Liefde I; Birzbier B B; Vanderheyden P M L
New insights in insurmountable antagonism.
Fundamental & clinical pharmacology 2002;16(4):263-72.
2002: Le Minh Tam; Vanderheyden Patrick M L; Szaszák Márta; Hunyady László; Vauquelin Georges
Angiotensin IV is a potent agonist for constitutive active human AT1 receptors. Distinct roles of the N-and C-terminal residues of angiotensin II during AT1 receptor activation.
The Journal of biological chemistry 2002;277(26):23107-10.
2002: Le Minh Tam; Vanderheyden Patrick M L; Baggerman Geert; Broeck Jozef Vanden; Vauquelin Georges
Formation of angiotensin-(1-7) from angiotensin II by the venom of Conus geographus.
Regulatory peptides 2002;105(2):101-8.
2002: Fierens Frederik L P; Vanderheyden Patrick M L; Roggeman Chantal; Vande Gucht Pascal; De Backer Jean Paul; Vauquelin Georges
Distinct binding properties of the AT(1) receptor antagonist [(3)H]candesartan to intact cells and membrane preparations.
Biochemical pharmacology 2002;63(7):1273-9.
2001: Vauquelin G; Fierens F; Verheijen I; Vanderheyden P
Insurmountable AT(1) receptor antagonism: the need for different antagonist binding states of the receptor.
Trends in pharmacological sciences 2001;22(7):343-4.
2001: Fierensa F L; Vanderheyden P M; Roggeman C; De Backer J; Thekkumkara T J; Vauquelin G
Tight binding of the angiotensin AT(1) receptor antagonist.
Biochemical pharmacology 2001;61(10):1227-35.
2001: Van Liefde; Vanderheyden P M; De Backer J P; Ebinger G; Vauquelin G
Effects of BIBP3226 and BIBP3435 on cytosolic calcium in neuropeptide Y Y1 receptor-transfected Chinese hamster ovary cells and wild type CHO-K1 cells.
Journal of receptor and signal transduction research 2001;21(1):11-23.
2001: Vauquelin G; Morsing P; Fierens F L; De Backer J P; Vanderheyden P M
A two-state receptor model for the interaction between angiotensin II type 1 receptors and non-peptide antagonists.
Biochemical pharmacology 2001;61(3):277-84.
2001: Caballero-George C; Vanderheyden P M; Solis P N; Pieters L; Shahat A A; Gupta M P; Vauquelin G; Vlietinck A J
Biological screening of selected medicinal Panamanian plants by radioligand-binding techniques.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2001;8(1):59-70.
2000: Vanderheyden P M; Verheijen I; Fierens F L; DeBacker J P; Vauquelin G
Inhibition of angiotensin II-induced inositol phosphate production by triacid nonpeptide antagonists in CHO cells expressing human AT1 receptors.
Pharmaceutical research 2000;17(12):1482-8.
2000: Fraeyman N; Van de Velde E; Van Ermen A; Bazan A; Vanderheyden P; Van Emmelo J; Vandekerckhove J
Effect of maturation and aging on beta-adrenergic signal transduction in rat kidney and liver.
Biochemical pharmacology 2000;60(12):1787-95.
2000: Vanderheyden P M; Fierens F L; Vauquelin G
Angiotensin II type 1 receptor antagonists. Why do some of them produce insurmountable inhibition?
Biochemical pharmacology 2000;60(11):1557-63.
2000: Verheijen I; Fierens F L; Debacker J P; Vauquelin G; Vanderheyden P M
Interaction between the partially insurmountable antagonist valsartan and human recombinant angiotensin II type 1 receptors.
Fundamental & clinical pharmacology 2000;14(6):577-85.
2000: Fierens F L; Vanderheyden P M; Gáborik Z; Minh T L; Backer J P; Hunyady L; Ijzerman A; Vauquelin G
Lys(199) mutation of the human angiotensin type 1 receptor differentially affects the binding of surmountable and insurmountable non-peptide antagonists.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2000;1(3):283-8.
2000: Vanderheyden P M; Verheijen I; Fierens F L; Backer J P; Vauquelin G
Binding characteristics of [(3)H]-irbesartan to human recombinant angiotensin type 1 receptors.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2000;1(2):159-65.
2000: Vanderheyden P M; Fierens F L; De Backer J; Vauquelin G
Reversible and syntopic interaction between angiotensin receptor antagonists on Chinese hamster ovary cells expressing human angiotensin II type 1 receptors.
Biochemical pharmacology 2000;59(8):927-35.
1999: Le M T; Vanderheyden P M; De Backer J P; Vanquelin G; Broeck J V
High affinity displacement of [(3)H]NPY binding to the crude venom of conus anemone by insect neuropeptides.
Biochemical and biophysical research communications 1999;262(1):180-6.
1999: Fierens F L; Vanderheyden P M; De Backer J P; Vauquelin G
Insurmountable angiotensin AT1 receptor antagonists: the role of tight antagonist binding.
European journal of pharmacology 1999;372(2):199-206.
1999: Vanderheyden P M; Fierens F L; De Backer J P; Fraeyman N; Vauquelin G
Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors.
British journal of pharmacology 1999;126(4):1057-65.
1999: Fierens F; Vanderheyden P M; De Backer J P; Vauquelin G
Binding of the antagonist [3H]candesartan to angiotensin II AT1 receptor-transfected [correction of tranfected] Chinese hamster ovary cells.
European journal of pharmacology 1999;367(2-3):413-22.
1999: Vauquelin G; Fierens F L; De Backer J P; Vanderheyden P M
The effects of candesartan on human AT1 receptor-expressing Chinese hamster ovary cells.
Journal of the American Society of Nephrology : JASN 1999;10 Suppl 11():S15-7.
1998: Vanderheyden P M; Van Liefde I; DeBacker J P; Ebinger G; Vauquelin G
Effect of BIBP3226 on inositol phosphate accumulation and cytosolic calcium level in control and NPY Y1 receptor expressing CHO-K1 cells.
Regulatory peptides 1998;75-76():191-9.
1998: Vanderheyden P M; Van Liefde I; de Backer J P; Vauquelin G
[3H]-BIBP3226 and [3H]-NPY binding to intact SK-N-MC cells and CHO cells expressing the human Y1 receptor.
Journal of receptor and signal transduction research 1998;18(4-6):363-85.
1998: Van Liefde I; Vanderheyden P M; Fraeyman N; De Backer J P; Vauquelin G
Human neuropeptide YY1 receptors exert unequal control of the extracellular acidification rate in different cell lines.
European journal of pharmacology 1998;346(1):87-95.
1998: Diallo B; Vanderheyden P M; De Backer J P; Vauquelin G
The venom of Conus pennaceus inhibits the binding of [3H]neuropeptide Y by direct interaction with the radioligand.
Neurochemistry international 1998;32(1):39-46.
1997: Vanderheyden P M; Van Liefde I; De Backer J P; Vauquelin G
Non-competitive binding of the nonpeptide antagonist BIBP3226 to rat forebrain neuropeptide Y1 receptors.
European journal of pharmacology 1997;331(2-3):275-84.
1996: Czerwiec E; de Backer J P; Vauquelin G; Vanderheyden P M
Neuropeptide Y receptors from calf brain: effect of crude Conus venom preparations on [3H]NPY binding.
Neurochemistry international 1996;29(6):669-76.
1996: Czerwiec E; De Backer J P; Vauquelin G; Vanderheyden P M
High-affinity binding of [3H]neuropeptide Y to a polypeptide from the venom of Conus anemone.
European journal of pharmacology 1996;315(3):355-62.
1990: Vauquelin G; Vanderheyden P; Ebinger G
Dual effect of N-ethylmaleimide on agonist binding to bovine heart muscarinic receptors.
Archives internationales de pharmacodynamie et de thérapie 1990;307():5-10.
1988: De Keyser J; Ebinger G; De Backer J P; Convents A; Vanderheyden P; Vauquelin G
Subtypes of adrenergic and dopaminergic receptors in bovine cerebral blood vessels.
Neuroscience letters 1988;85(2):272-6.
1988: Vanderheyden P; Ebinger G; Vauquelin G
Characterization of M1- and M2-muscarinic receptors in calf retina membranes.
Vision research 1988;28(2):247-50.
1986: Vanderheyden P; Ebinger G; De Backer J P; Vauquelin G
Identification of M2 muscarinic receptors in membranes from bovine cerebral basal arteries.
Life sciences 1986;39(17):1517-23.
1984: Vanderheyden P; Andre C; de Backer J P; Vauquelin G
Agonist mediated conformational changes of solubilized calf forebrain muscarinic acetylcholine receptors.
Biochemical pharmacology 1984;33(19):2981-7.
1984: André C; Guillet J G; De Backer J P; Vanderheyden P; Hoebeke J; Strosberg A D
Monoclonal antibodies against the native or denatured forms of muscarinic acetylcholine receptors.
The EMBO journal 1984;3(1):17-21.
1983: André C; De Backer J P; Guillet J C; Vanderheyden P; Vauquelin G; Strosberg A D
Purification of muscarinic acetylcholine receptors by affinity chromatography.
The EMBO journal 1983;2(4):499-504.

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