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Heikki Vapaatalo

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Co-Publications
Name
44
Korpela, Riitta
34
Mervaala, Eero
28
Moilanen, Eeva
27
Pörsti, Ilkka
22
Alanko, Juha
21
Arvola, Pertti
20
Metsä-Ketelä, Timo
20
Laakso, Juha
18
Karppanen, Heikki
16
Riutta, Asko
16
Paakkari, Ilari
16
Seppälä, Erkki
15
Lähteenmäki, TA
14
Mucha, István
14
Nevala, Riikka

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Publications

TOP 3
Luhtala Satu; Vaajanen Anu; Oksala Olli; Valjakka Jarkko; Vapaatalo Heikki
Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues.
Volotinen Marjo; Mäenpää Jukka; Kautiainen Hannu; Tolonen Ari; Uusitalo Jouko; Ropo Auli; Vapaatalo Heikki; Aine Esko
Ophthalmic timolol in a hydrogel vehicle leads to minor inter-individual variation in timolol concentration in aqueous humor.
Myllyluoma E; Ahonen A-M; Korpela R; Vapaatalo H; Kankuri E
Effects of multispecies probiotic combination on helicobacter pylori infection in vitro.

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All Publications

2009: Luhtala Satu; Vaajanen Anu; Oksala Olli; Valjakka Jarkko; Vapaatalo Heikki
Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2009;25(1):23-8.
2009: Volotinen Marjo; Mäenpää Jukka; Kautiainen Hannu; Tolonen Ari; Uusitalo Jouko; Ropo Auli; Vapaatalo Heikki; Aine Esko
Ophthalmic timolol in a hydrogel vehicle leads to minor inter-individual variation in timolol concentration in aqueous humor.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;36(2-3):292-6.
2008: Myllyluoma E; Ahonen A-M; Korpela R; Vapaatalo H; Kankuri E
Effects of multispecies probiotic combination on helicobacter pylori infection in vitro.
Clinical and vaccine immunology : CVI 2008;15(9):1472-82.
2008: Vaajanen Anu; Vapaatalo Heikki; Kautiainen Hannu; Oksala Olli
Angiotensin (1-7) reduces intraocular pressure in the normotensive rabbit eye.
Investigative ophthalmology & visual science 2008;49(6):2557-62.
2008: Kekkonen Riina-A; Sysi-Aho Marko; Seppanen-Laakso Tuulikki; Julkunen Ilkka; Vapaatalo Heikki; Oresic Matej; Korpela Riitta
Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults.
World journal of gastroenterology : WJG 2008;14(20):3188-94.
2008: Vaajanen A; Mervaala E; Oksala O; Vapaatalo H
Is there a relationship between blood pressure and intraocular pressure? An experimental study in hypertensive rats.
Current eye research 2008;33(4):325-32.
2008: Kekkonen Riina-A; Lummela Netta; Karjalainen Heli; Latvala Sinikka; Tynkkynen Soile; Jarvenpaa Salme; Kautiainen Hannu; Julkunen Ilkka; Vapaatalo Heikki; Korpela Riitta
Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults.
World journal of gastroenterology : WJG 2008;14(13):2029-36.
2008: Kajander K; Myllyluoma E; Rajilic-Stojanovic M; Kyrönpalo S; Rasmussen M; Järvenpää S; Zoetendal E G; de Vos W M; Vapaatalo H; Korpela R
Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota.
Alimentary pharmacology & therapeutics 2008;27(1):48-57.
2008: Vaajanen Anu; Luhtala Satu; Oksala Olli; Vapaatalo Heikki
Does the renin-angiotensin system also regulate intra-ocular pressure?
Annals of medicine 2008;40(6):418-27.
2007: Pilvi Taru K; Korpela Riitta; Huttunen Minna; Vapaatalo Heikki; Mervaala Eero M
High-calcium diet with whey protein attenuates body-weight gain in high-fat-fed C57Bl/6J mice.
The British journal of nutrition 2007;98(5):900-7.
2007: Holma R; Salmenperä P; Virtanen I; Vapaatalo H; Korpela R
Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2007;58(3):455-67.
2007: Myllyluoma E; Kajander K; Mikkola H; Kyrönpalo S; Rasmussen M; Kankuri E; Sipponen P; Vapaatalo H; Korpela R
Probiotic intervention decreases serum gastrin-17 in Helicobacter pylori infection.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2007;39(6):516-23.
2007: Vaajanen Anu; Vapaatalo Heikki; Oksala Olli
A modified in vitro method for aqueous humor outflow studies in enucleated porcine eyes.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2007;23(2):124-31.
2007: Vapaatalo Heikki; Viinikka Lasse
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2007;123(13):1538-9.
2007: Back Johan; Kankuri Esko; Ikonen Tuija; Pätilä Tommi; Sinisalo Juha; Laine Mika; Vapaatalo Heikki; Koponen Jonna; Hukkanen Mika; Ylä-Herttuala Seppo; Alitalo Riitta; Kupari Markku; Harjula Ari
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2007;123(4):398-405.
2007: Narva Mirkka; Rissanen Jukka; Halleen Jussi; Vapaatalo Heikki; Väänänen Kalervo; Korpela Riitta
Effects of bioactive peptide, valyl-prolyl-proline (VPP), and lactobacillus helveticus fermented milk containing VPP on bone loss in ovariectomized rats.
Annals of nutrition & metabolism 2007;51(1):65-74.
2006: Asmawi M Z; Seppo L; Vapaatalo H; Korpela R
Hypolactasia & lactose intolerance among three ethnic groups in Malaysia.
The Indian journal of medical research 2006;124(6):697-704.
2006: Oresmaa L; Kotikoski H; Haukka M; Oksala O; Pohjala E; Vapaatalo H; Moilanen E; Vainiotalo P; Aulaskari P
Synthesis, ocular effects, and nitric oxide donation of imidazole amidoximes.
European journal of medicinal chemistry 2006;41(9):1073-9.
2006: Pilvi T K; Jauhiainen T; Cheng Z J; Mervaala E M; Vapaatalo H; Korpela R
Lupin protein attenuates the development of hypertension and normalises the vascular function of NaCl-loaded Goto-Kakizaki rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2006;57(2):167-76.
2006: Oresmaa Larisa; Kotikoski Hanna; Haukka Matti; Oksala Olli; Pohjala Esko; Vapaatalo Heikki; Vainiotalo Pirjo; Aulaskari Paula
Synthesis and ocular effects of imidazole nitrolic acid and amidoxime esters.
Bioorganic & medicinal chemistry letters 2006;16(8):2144-7.
2005: Jauhiainen Tiina; Vapaatalo Heikki; Poussa Tuija; Kyrönpalo Sinikka; Rasmussen Martin; Korpela Riitta
Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement.
American journal of hypertension 2005;18(12 Pt 1):1600-5.
2005: Seppo L; Lähteenmäki T; Tikkanen M J; Vanhanen H; Korpela R; Vapaatalo H
Effects of vitamin E on the toxicity of oxidized LDL on endothelial cells in vitro in smokers vs nonsmokers on diets rich in fish.
European journal of clinical nutrition 2005;59(11):1282-90.
2005: Vapaatalo Heikki; Korpela Riitta; Jauhiainen Tiina
Response to Dr. Mizushima.
American journal of hypertension 2005;18(7):1015.
2005: Oresmaa Larisa; Kotikoski Hanna; Haukka Matti; Salminen Johanna; Oksala Olli; Pohjala Esko; Moilanen Eeva; Vapaatalo Heikki; Vainiotalo Pirjo; Aulaskari Paula
Synthesis and ocular effects of imidazole nitrolic acids.
Journal of medicinal chemistry 2005;48(13):4231-6.
2005: Cheng Zhong Jian; Vapaatalo Heikki; Mervaala Eero
Angiotensin II and vascular inflammation.
Medical science monitor : international medical journal of experimental and clinical research 2005;11(6):RA194-205.
2005: Myllyluoma E; Veijola L; Ahlroos T; Tynkkynen S; Kankuri E; Vapaatalo H; Rautelin H; Korpela R
Probiotic supplementation improves tolerance to Helicobacter pylori eradication therapy--a placebo-controlled, double-blind randomized pilot study.
Alimentary pharmacology & therapeutics 2005;21(10):1263-72.
2005: Finckenberg Piet; Merasto Saara; Louhelainen Marjut; Lindgren Leena; Vapaatalo Heikki; Müller Dominik N; Luft Friedrich C; Mervaala Eero M A
Magnesium supplementation prevents angiotensin II-induced myocardial damage and CTGF overexpression.
Journal of hypertension 2005;23(2):375-80.
2004: Bizik J; Kankuri E; Ristimäki A; Taïeb A; Vapaatalo H; Lubitz W; Vaheri A
Cell-cell contacts trigger programmed necrosis and induce cyclooxygenase-2 expression.
Cell death and differentiation 2004;11(2):183-95.
2004: Narva Mirkka; Collin Marika; Lamberg-Allardt Christel; Kärkkäinen Merja; Poussa Tuija; Vapaatalo Heikki; Korpela Riitta
Effects of long-term intervention with Lactobacillus helveticus-fermented milk on bone mineral density and bone mineral content in growing rats.
Annals of nutrition & metabolism 2004;48(4):228-34.
2003: Kotikoski Hanna; Oksala Olli; Vapaatalo Heikki; Aine Esko
Aqueous humour flow after a single oral dose of isosorbide-5-mononitrate in healthy volunteers.
Acta ophthalmologica Scandinavica 2003;81(4):355-60.
2003: Mervaala Eero; Finckenberg Piet; Lapatto Risto; Müller Dominik N; Park Joon-Keun; Dechend Ralf; Ganten Detlev; Vapaatalo Heikki; Luft Friedrich C
Lipoic acid supplementation prevents angiotensin II-induced renal injury.
Kidney international 2003;64(2):501-8.
2003: Finckenberg Piet; Inkinen Kaija; Ahonen Juhani; Merasto Saara; Louhelainen Marjut; Vapaatalo Heikki; Müller Dominik; Ganten Detlev; Luft Friedrich; Mervaala Eero
Angiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathways.
The American journal of pathology 2003;163(1):355-66.
2003: Kankuri Esko; Solatunturi Erkka; Vapaatalo Heikki
Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro.
Thrombosis research 2003;110(5-6):299-303.
2003: Ojanen Raimo; Kaukinen Liisa; Seppälä Erkki; Kaukinen Seppo; Vapaatalo Heikki
Single dose of acetylsalicylic acid prevents thromboxane release after tourniquet ischemia.
The Journal of trauma 2003;54(5):986-9.
2003: Kotikoski Hanna; Vapaatalo Heikki; Oksala Olli
Nitric oxide and cyclic GMP enhance aqueous humor outflow facility in rabbits.
Current eye research 2003;26(2):119-23.
2003: Kankuri E; Hämäläinen M; Hukkanen M; Salmenperä P; Kivilaakso E; Vapaatalo H; Moilanen E
Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis.
Scandinavian journal of gastroenterology 2003;38(2):186-92.
2003: Cheng Zhong Jian; Finckenberg Piet; Louhelainen Marjut; Merasto Saara; Tikkanen Ilkka; Vapaatalo Heikki; Mervaala Eero M A
Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene (TGR[mREN2]27).
European journal of pharmacology 2003;461(2-3):159-69.
2003: Kotikoski Hanna; Kankuri Esko; Vapaatalo Heikki
Incubation of porcine iris-ciliary bodies to study the mechanisms by which nitric oxide donors lower intraocular pressure.
Medical science monitor : international medical journal of experimental and clinical research 2003;9(1):BR1-7.
2002: Cheng Z J; Tikkanen I; Vapaatalo H; Mervaala E M A
Vascular effects of COX inhibition and AT1 receptor blockade in transgenic rats harboring mouse renin-2 gene.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2002;53(4 Pt 1):597-613.
2002: Holma R; Juvonen P; Asmawi M Z; Vapaatalo H; Korpela R
Galacto-oligosaccharides stimulate the growth of bifidobacteria but fail to attenuate inflammation in experimental colitis in rats.
Scandinavian journal of gastroenterology 2002;37(9):1042-7.
2002: Nevala Riikka; Lassila Markus; Finckenberg Piet; Paukku Kirsi; Korpela Riitta; Vapaatalo Heikki
Genistein treatment reduces arterial contractions by inhibiting tyrosine kinases in ovariectomized hypertensive rats.
European journal of pharmacology 2002;452(1):87-96.
2002: Sipola Marika; Finckenberg Piet; Vapaatalo Heikki; Pihlanto-Leppälä Anne; Korhonen Hannu; Korpela Riitta; Nurminen Marja-Leena
Alpha-lactorphin and beta-lactorphin improve arterial function in spontaneously hypertensive rats.
Life sciences 2002;71(11):1245-53.
2002: Kotikoski Hanna; Moilanen Eeva; Vapaatalo Heikki; Aine Esko
Biochemical markers of the L-arginine-nitric oxide pathway in the aqueous humour in glaucoma patients.
Acta ophthalmologica Scandinavica 2002;80(2):191-5.
2002: Sipola Marika; Finckenberg Piet; Korpela Riitta; Vapaatalo Heikki; Nurminen Marja-Leena
Effect of long-term intake of milk products on blood pressure in hypertensive rats.
The Journal of dairy research 2002;69(1):103-11.
2002: Kotikoski Hanna; Alajuuma Päivi; Moilanen Eeva; Salmenperä Pertteli; Oksala Olli; Laippala Pekka; Vapaatalo Heikki
Comparison of nitric oxide donors in lowering intraocular pressure in rabbits: role of cyclic GMP.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2002;18(1):11-23.
2001: Sipola M; Finckenberg P; Santisteban J; Korpela R; Vapaatalo H; Nurminen M L
Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2001;52(4 Pt 2):745-54.
2001: Kankuri E; Vaali K; Korpela R; Paakkari I; Vapaatalo H; Moilanen E
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.
Inflammation 2001;25(5):301-10.
2001: Holma R; Salmenperä P; Riutta A; Virtanen I; Korpela R; Vapaatalo H
Acute effects of the cys-leukotriene-1 receptor antagonist, montelukast, on experimental colitis in rats.
European journal of pharmacology 2001;429(1-3):309-18.
2001: Vapaatalo H; Mervaala E
Clinically important factors influencing endothelial function.
Medical science monitor : international medical journal of experimental and clinical research 2001;7(5):1075-85.
2001: Kankuri E; Vaali K; Knowles R G; Lähde M; Korpela R; Vapaatalo H; Moilanen E
Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine.
The Journal of pharmacology and experimental therapeutics 2001;298(3):1128-32.
2001: Nevala R; Paukku K; Korpela R; Vapaatalo H
Calcium-sensitive potassium channel inhibitors antagonize genistein- and daidzein-induced arterial relaxation in vitro.
Life sciences 2001;69(12):1407-17.
2001: Holma R; Salmenperä P; Lohi J; Vapaatalo H; Korpela R
Effects of Lactobacillus rhamnosus GG and Lactobacillus reuteri R2LC on acetic acid-induced colitis in rats.
Scandinavian journal of gastroenterology 2001;36(6):630-5.
2001: Norio K; Saareks V; Vapaatalo H; Mäkisalo H; Pere P; Lindgren L
Eicosanoids and delayed graft function in human renal transplantation.
Transplantation proceedings 2001;33(4):2530-1.
2001: Finckenberg P; Lassila M; Inkinen K; Pere A K; Krogerus L; Lindgren L; Mervaala E; Vapaatalo H; Nurminen M L; Ahonen J
Cyclosporine induces myocardial connective tissue growth factor in spontaneously hypertensive rats on high-sodium diet.
Transplantation 2001;71(7):951-8.
2001: Lassila M; Santisteban J; Finckenberg P; Salmenperä P; Riutta A; Moilanen E; Virtanen I; Vapaatalo H; Nurminen M L
Vascular changes in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2001;52(1):21-38.
2001: Cheng Z J; Vaskonen T; Tikkanen I; Nurminen K; Ruskoaho H; Vapaatalo H; Muller D; Park J K; Luft F C; Mervaala E M
Endothelial dysfunction and salt-sensitive hypertension in spontaneously diabetic Goto-Kakizaki rats.
Hypertension 2001;37(2 Part 2):433-9.
2001: Mervaala E M; Cheng Z J; Tikkanen I; Lapatto R; Nurminen K; Vapaatalo H; Müller D N; Fiebeler A; Ganten U; Ganten D; Luft F C
Endothelial dysfunction and xanthine oxidoreductase activity in rats with human renin and angiotensinogen genes.
Hypertension 2001;37(2 Part 2):414-8.
2000: Saareks V; Riutta A; Alanko J; Ylitalo P; Parviainen M; Mucha I; Sievi E; Vapaatalo H
Clinical pharmacology of eicosanoids, nicotine induced changes in man.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2000;51(4 Pt 1):631-42.
2000: Pere A K; Lindgren L; Tuomainen P; Krogerus L; Rauhala P; Laakso J; Karppanen H; Vapaatalo H; Ahonen J; Mervaala E M
Dietary potassium and magnesium supplementation in cyclosporine-induced hypertension and nephrotoxicity.
Kidney international 2000;58(6):2462-72.
2000: Peuhkuri K; Vapaatalo H; Korpela R
Wide variations in the testing of lactose tolerance: results of a questionnaire study in Finnish health care centres.
Scandinavian journal of clinical and laboratory investigation 2000;60(4):291-7.
2000: Lassila M; Finckenberg P; Pere A K; Krogerus L; Ahonen J; Vapaatalo H; Nurminen M L
Comparison of enalapril and valsartan in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet.
British journal of pharmacology 2000;130(6):1339-47.
2000: Nevala R; Seppo L; Tikkanen M J; Laakso J; Vanhanen H; Vapaatalo H; Korpela R
Dietary fatty acid composition influences the degree of human LDL oxidation, but has only minor effects on vascular tone in a bioassay system.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2000;10(3):126-36.
2000: Seppo L; Karjala K; Nevala R; Korpela R; Lähteenmäki T; Solatunturi E; Tikkanen M J; Vapaatalo H
A long-term fish diet modifies the toxic properties of human partially oxidized LDL on vascular preparations in vitro.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2000;51(2):251-65.
2000: Vaali K; Li L; Lähteenmäki T; Vapaatalo H
Role of BK(Ca) channels and cyclic nucleotides in synergistic relaxation of trachea.
European journal of pharmacology 2000;399(1):75-84.
2000: Lassila M; Finckenberg P; Pere A K; Vapaatalo H; Nurminen M L
Enalapril and valsartan improve cyclosporine A-induced vascular dysfunction in spontaneously hypertensive rats.
European journal of pharmacology 2000;398(1):99-106.
2000: Peuhkuri K; Vapaatalo H; Nevala R; Korpela R
Temperature of a test solution influences abdominal symptoms in lactose tolerance tests.
Scandinavian journal of clinical and laboratory investigation 2000;60(1):75-80.
2000: Peuhkuri K; Vapaatalo H; Korpela R; Teuri U
Lactose intolerance-a confusing clinical diagnosis.
The American journal of clinical nutrition 2000;71(2):600-2.
2000: Vaskonen T; Mervaala E; Nevala R; Soots A; Krogerus L; Lähteenmäki T; Karppanen H; Vapaatalo H; Ahonen J
Development of chronic allograft rejection and arterial hypertension in Brown Norway rats after renal transplantation.
Blood pressure 2000;9(2-3):162-8.
2000: Vapaatalo H; Mervaala E; Nurminen M L
Role of endothelium and nitric oxide in experimental hypertension.
Physiological research / Academia Scientiarum Bohemoslovaca 2000;49(1):1-10.
2000: Nurminen M L; Sipola M; Kaarto H; Pihlanto-Leppälä A; Piilola K; Korpela R; Tossavainen O; Korhonen H; Vapaatalo H
Alpha-lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats.
Life sciences 2000;66(16):1535-43.
2000: Lähteenmäki T A; Seppo L; Laakso J; Korpela R; Vanhanen H; Tikkanen M J; Vapaatalo H
Oxidized LDL from subjects with different dietary habits modifies atherogenic processes in endothelial and smooth muscle cells.
Life sciences 2000;66(5):455-65.
2000: Nevala R; Vaskonen T; Vehniäinen J; Korpela R; Vapaatalo H
Soy based diet attenuates the development of hypertension when compared to casein based diet in spontaneously hypertensive rat.
Life sciences 2000;66(2):115-24.
1999: Nurminen M L; Niittynen L; Korpela R; Vapaatalo H
Coffee, caffeine and blood pressure: a critical review.
European journal of clinical nutrition 1999;53(11):831-9.
1999: Li L; Vaali K; Vapaatalo H; Kankaanranta H
Effects of K(+) channel inhibitors on relaxation induced by flufenamic and tolfenamic acids in guinea-pig trachea.
European journal of pharmacology 1999;383(2):169-76.
1999: Korpela R; Seppo L; Laakso J; Lilja J; Karjala K; Lähteenmäki T; Solatunturi E; Vapaatalo H; Tikkanen M J
Dietary habits affect the susceptibility of low-density lipoprotein to oxidation.
European journal of clinical nutrition 1999;53(10):802-7.
1999: Peuhkuri K; Nevala R; Vapaatalo H; Moilanen E; Korpela R
Ibuprofen augments gastrointestinal symptoms in lactose maldigesters during a lactose tolerance test.
Alimentary pharmacology & therapeutics 1999;13(9):1227-33.
1999: Sinisalo J; Vanhanen H; Pajunen P; Vapaatalo H; Nieminen M S
Ursodeoxycholic acid and endothelial-dependent, nitric oxide-independent vasodilatation of forearm resistance arteries in patients with coronary heart disease.
British journal of clinical pharmacology 1999;47(6):661-5.
1999: Teuri U; Vapaatalo H; Korpela R
Fructooligosaccharides and lactulose cause more symptoms in lactose maldigesters and subjects with pseudohypolactasia than in control lactose digesters.
The American journal of clinical nutrition 1999;69(5):973-9.
1999: Kankuri E; Asmawi M Z; Korpela R; Vapaatalo H; Moilanen E
Induction of iNOS in a rat model of acute colitis.
Inflammation 1999;23(2):141-52.
1999: Peuhkuri K; Vapaatalo H; Nevala R; Korpela R
Influence of the pharmacological modification of gastric emptying on lactose digestion and gastrointestinal symptoms.
Alimentary pharmacology & therapeutics 1999;13(1):81-6.
1999: Alanko J; Riutta A; Holm P; Mucha I; Vapaatalo H; Metsä-Ketelä T
Modulation of arachidonic acid metabolism by phenols: relation to their structure and antioxidant/prooxidant properties.
Free radical biology & medicine 1999;26(1-2):193-201.
1999: Laakso J; Vaskonen T; Mervaala E; Vapaatalo H; Lapatto R
Inhibition of nitric oxide synthase induces renal xanthine oxidoreductase activity in spontaneously hypertensive rats.
Life sciences 1999;65(25):2679-85.
1999: Mervaala E; Lassila M; Vaskonen T; Krogerus L; Lähteenmäki T; Vapaatalo H; Karppanen H
Effects of ACE inhibition on cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on a high-sodium diet.
Blood pressure 1999;8(1):49-56.
1998: Vaali K; Li L; Vapaatalo H
Interactions between beta2-adrenoreceptor agonist and NO donors in the relaxation of guinea pig trachea in vitro.
European journal of pharmacology 1998;363(2-3):169-74.
1998: Laakso J; Mervaala E; Himberg J J; Teräväinen T L; Karppanen H; Vapaatalo H; Lapatto R
Increased kidney xanthine oxidoreductase activity in salt-induced experimental hypertension.
Hypertension 1998;32(5):902-6.
1998: Lähteenmäki T; Sievi E; Vapaatalo H
Inhibitory effects of mesoionic 3-aryl substituted oxatriazole-5-imine derivatives on vascular smooth muscle cell mitogenesis and proliferation in vitro.
British journal of pharmacology 1998;125(2):402-8.
1998: Saareks V; Mucha I; Sievi E; Vapaatalo H; Riutta A
Nicotine stereoisomers and cotinine stimulate prostaglandin E2 but inhibit thromboxane B2 and leukotriene E4 synthesis in whole blood.
European journal of pharmacology 1998;353(1):87-92.
1998: Vaali K; Li L; Paakkari I; Vapaatalo H
Relaxing effects of NO donors on guinea pig trachea in vitro are mediated by calcium-sensitive potassium channels.
The Journal of pharmacology and experimental therapeutics 1998;286(1):110-4.
1998: Vaskonen T; Mervaala E; Teräväinen T L; Laakso J; Karppanen H; Vapaatalo H
Cardiovascular effects of dietary salts and isosorbide-5-mononitrate in spontaneously hypertensive rats.
Blood pressure 1998;7(3):184-92.
1998: Nurminen M L; Korpela R; Vapaatalo H
Dietary factors in the pathogenesis and treatment of hypertension.
Annals of medicine 1998;30(2):143-50.
1998: Li L; Paakkari I; Vapaatalo H
Effects of K+ channel inhibitors on the basal tone and KCl- or methacholine-induced contraction of mouse trachea.
European journal of pharmacology 1998;346(2-3):255-60.
1998: Li L; Vaali K; Paakkari I; Vapaatalo H
Involvement of bradykinin B1 and B2 receptors in relaxation of mouse isolated trachea.
British journal of pharmacology 1998;123(7):1337-42.
1998: Pere A K; Krogerus L; Mervaala E M; Laakso J; Karppanen H; Inkinen K; Pere P; Ahonen J; Vapaatalo H; Lindgren L
Detrimental effect of dietary sodium and beneficial effect of dietary magnesium on glomerular changes in cyclosporin-A-treated spontaneously hypertensive rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1998;13(4):904-10.
1998: Mervaala E M; Malmberg L; Teräväinen T L; Laakso J; Vapaatalo H; Karppanen H
Influence of dietary salts on the cardiovascular effects of low-dose combination of ramipril and felodipine in spontaneously hypertensive rats.
British journal of pharmacology 1998;123(2):195-204.
1998: Alanko J; Sievi E; Lähteenmäki T; Mucha I; Vapaatalo H; Parantainen J
Catechol estrogens as inhibitors of leukotriene synthesis.
Biochemical pharmacology 1998;55(1):101-4.
1998: Lähteenmäki T A; Korpela R; Tikkanen M J; Karjala K; Laakso J; Solatunturi E; Vapaatalo H
Proliferative effects of oxidized low-density lipoprotein on vascular smooth muscle cells: role of dietary habits.
Life sciences 1998;63(12):995-1003.
1998: Nevala R; Korpela R; Vapaatalo H
Plant derived estrogens relax rat mesenteric artery in vitro.
Life sciences 1998;63(6):PL 95-100.
1998: Li L; Vapaatalo H; Vaali K; Paakkari I; Kankaanranta H
Flufenamic and tolfenamic acids and lemakalim relax guinea-pig isolated trachea by different mechanisms.
Life sciences 1998;62(20):PL 303-8.
1998: Li L; Vapaatalo H; Vaali K; Paakkari I; Kankaanranta H
Fenamates inhibit contraction of guinea-pig isolated bronchus in vitro independent of prostanoid synthesis inhibition.
Life sciences 1998;62(19):PL289-94.
1997: Peuhkuri K; Hukkanen M; Beale R; Polak J M; Vapaatalo H; Korpela R
Age and continuous lactose challenge modify lactase protein expression and enzyme activity in gut epithelium in the rat.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1997;48(4):719-29.
1997: Sievi E; Lähteenmäki T A; Alanko J; Vuorinen P; Vapaatalo H
Nitric oxide as a regulator of prostacyclin synthesis in cultured rat heart endothelial cells.
Arzneimittel-Forschung 1997;47(10):1093-8.
1997: Vaskonen T; Mervaala E; Krogerus L; Teräväinen T L; Laakso J; Karppanen H; Vapaatalo H
Cardiovascular effects of chronic inhibition of nitric oxide synthesis and dietary salt in spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 1997;20(3):183-92.
1997: Teräväinen T L; Mervaala E M; Laakso J; Paakkari I; Vapaatalo H; Karppanen H
Influence of age on cardiovascular effects of increased dietary sodium and angiotensin-converting enzyme inhibition in normotensive Wistar rats.
The Journal of pharmacy and pharmacology 1997;49(9):912-8.
1997: Li L; Kankaanranta H; Vaali K; Paakkari I; Vapaatalo H
Econazole, miconazole and SK & F 96365 inhibit depolarization-induced and receptor-operated contraction of guinea-pig isolated trachea in vitro.
European journal of pharmacology 1997;331(2-3):221-5.
1997: Mervaala E M; Malmberg L; Teräväinen T L; Lähteenmäki T; Karjala K; Paakkari I; Pörsti I; Mest H J; Vapaatalo H; Karppanen H
Influence of different dietary salts on the cardiovascular and renal effects of moxonidine in spontaneously hypertensive rats.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(1):107-14.
1997: Teräväinen T L; Mervaala E M; Pörsti I; Laakso J; Vapaatalo H; Karppanen H
Influence of age and dietary sodium on the cardiovascular and renal effects of ramipril in spontaneously hypertensive rats.
Methods and findings in experimental and clinical pharmacology 1997;19(5):311-21.
1997: Korpela R; Moilanen E; Saxelin M; Vapaatalo H
Lactobacillus rhamnosus GG (ATCC 53103) and platelet aggregation in vitro.
International journal of food microbiology 1997;37(1):83-6.
1997: Mervaala E M; Teräväinen T L; Malmberg L; Laakso J; Vapaatalo H; Karppanen H
Cardiovascular effects of a low-dose combination of ramipril and felodipine in spontaneously hypertensive rats.
British journal of pharmacology 1997;121(3):503-10.
1997: Mervaala E M; Teräväinen T L; Malmberg L; Laakso J; Pörsti I; Vapaatalo H; Karppanen H
Cardiovascular and renal effects of the combination of felodipine and metoprolol during a high-salt and a moderate-salt diet in spontaneously hypertensive rats.
Japanese circulation journal 1997;61(5):421-31.
1997: Mervaala E M; Pere A K; Lindgren L; Laakso J; Teräväinen T L; Karjala K; Vapaatalo H; Ahonen J; Karppanen H
Effects of dietary sodium and magnesium on cyclosporin A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats.
Hypertension 1997;29(3):822-7.
1997: Nurminen M L; Ylikorkala A; Vapaatalo H
Central inhibition of nitric oxide synthesis increases blood pressure and heart rate in anesthetized rats.
Methods and findings in experimental and clinical pharmacology 1997;19(1):35-41.
1997: Kankuri E; Vapaatalo H; Peuhkuri K; Solatunturi E; Lähteenmäki T; Korpela R
[ The role of nitric oxide in gastrointestinal regulation and disease state]
Duodecim; lääketieteellinen aikakauskirja 1997;113(6):485-93.
1997: Li L; Vaali K; Paakkari I; Vapaatalo H
Bradykinin, lemakalim and sodium nitroprusside relax the mouse trachea in vitro by different mechanisms.
Life sciences 1997;61(7):PL67-73.
1996: Vaali K; Li L; Redemann B; Paakkari I; Vapaatalo H
In-vitro bronchorelaxing effects of novel nitric oxide donors GEA 3268 and GEA 5145 in guinea-pigs and rats.
The Journal of pharmacy and pharmacology 1996;48(12):1309-14.
1996: Nurminen M L; Vapaatalo H
Effect of intracerebroventricular and intravenous administration of nitric oxide donors on blood pressure and heart rate in anaesthetized rats.
British journal of pharmacology 1996;119(7):1422-6.
1996: Kankaanranta H; Moilanen E; Tuomiranta T; Korpela M; Yli-Kerttula U; Isomäki H; Vapaatalo H
Peripheral blood neutrophil leukotriene B4 release and migration in rheumatoid arthritis.
Inflammation 1996;20(5):513-22.
1996: Nevala R; Paakkari I; Tarkkila L; Vapaatalo H
The effects of male gender and female sex hormone deficiency on the vascular responses of the rat in vitro.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1996;47(3):425-32.
1996: Redemann B; Vaali K; Li L; Paakkari I; Vapaatalo H
Effects of potassium-channel opener HOE 234 in guinea-pig airways.
The Journal of pharmacy and pharmacology 1996;48(6):619-23.
1996: Lähteenmäki T A; Sievi E; Vapaatalo H
Antihypertensive drugs reduce noradrenaline-induced hypertrophy of cultured myocardial cells.
The Journal of pharmacy and pharmacology 1996;48(3):323-6.
1996: Sallinen K; Arvola P; Wuorela H; Ruskoaho H; Vapaatalo H; Pörsti I
High calcium diet reduces blood pressure in exercised and nonexercised hypertensive rats.
American journal of hypertension 1996;9(2):144-56.
1996: Tarkkila L; Paakkari I; Mervaala E; Nevala R; Vapaatalo H
Indapamide treatment modifies the vascular reactivity of normotensive rat mesenteric arteries ex vivo.
Methods and findings in experimental and clinical pharmacology 1996;18(1):5-11.
1996: Kankaanranta H; Vapaatalo H
[Is it safe and efficient to use nonsteroidal anti-inflammatory agent by selective reduction of prostaglandin production?]
Duodecim; lääketieteellinen aikakauskirja 1996;112(5):419-24.
1996: Mervaala E M; Teräväinen T L; Pere A K; Lindgren L; Laakso J; Karjala K; Vapaatalo H; Ahonen J; Karppanen H
Dietary salt aggravates cyclosporin A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats: protection by oral magnesium supplementation.
Contributions to nephrology 1996;119():121-4.
1995: Manninen A; Wuorela H; Laippala P; Vapaatalo H
Intraplatelet free calcium and calcium-regulating hormones in plasma are not related to the antihypertensive effect of nifedipine in hypertensive pregnancy.
Pharmacology & toxicology 1995;77(5):327-32.
1995: Kerttula T; Kaukinen S; Riutta A; Seppälä E; Mucha I; Vapaatalo H; Alanko J
Effects of noradrenaline and dopamine infusions on arachidonic acid metabolism in man.
Thrombosis research 1995;80(2):169-78.
1995: Kankaanranta H; Wuorela H; Siltaloppi E; Vuorinen P; Vapaatalo H; Moilanen E
Inhibition of human neutrophil function by tolfenamic acid involves inhibition of Ca2+ influx.
European journal of pharmacology 1995;291(1):17-25.
1995: Mäkynen H; Kähönen M; Arvola P; Wuorela H; Vapaatalo H; Pörsti I
Dietary calcium and magnesium supplements in spontaneously hypertensive rats and isolated arterial reactivity.
British journal of pharmacology 1995;115(8):1455-62.
1995: Kerttula T; Riutta A; Kaukinen S; Metsä-Ketelä T; Seppälä E; Vapaatalo H; Alanko J
Noradrenaline and dopamine infusions modulate arachidonic acid cyclooxygenase and 5-lipoxygenase pathways ex vivo in man.
Prostaglandins, leukotrienes, and essential fatty acids 1995;53(1):47-52.
1995: Kankaanranta H; Moilanen E; Lindberg K; Vapaatalo H
Pharmacological control of human polymorphonuclear leukocyte degranulation by fenamates and inhibitors of receptor-mediated calcium entry and protein kinase C.
Biochemical pharmacology 1995;50(2):197-203.
1995: Riutta A; Saareks V; Mucha I; Alanko J; Parviainen M; Vapaatalo H
Smoking cessation and nicotine substitution modulate eicosanoid synthesis ex vivo in man.
Naunyn-Schmiedeberg's archives of pharmacology 1995;352(1):102-7.
1995: Moilanen E; Vapaatalo H
Nitric oxide in inflammation and immune response.
Annals of medicine 1995;27(3):359-67.
1995: Alanko J; Riutta A; Vapaatalo H
Phenols inhibit prostaglandin E2 synthesis in A23187-stimulated human whole blood and modify the ratio of arachidonic acid metabolites.
Prostaglandins, leukotrienes, and essential fatty acids 1995;52(5):299-301.
1995: Paakkari I; Nevala R; Peitola A; Vapaatalo H
Effect of nitric oxide donors on rat bronchial muscle in vitro.
Agents and actions. Supplements 1995;45():207-11.
1995: Alanko J; Sievi E; Lähteenmäki T; Mucha I; Riutta A; Vapaatalo H
Effects of NO-donors, SIN-1 and GEA 3175 on prostacyclin and cGMP synthesis in cultured rat endothelial cells.
Agents and actions. Supplements 1995;45():195-9.
1994: Mervaala E M; Laakso J; Vapaatalo H; Karppanen H
Effects of enalapril and hydrochlorothiazide on the salt-induced cardiac and renal hypertrophy in normotensive rats.
Naunyn-Schmiedeberg's archives of pharmacology 1994;350(4):416-25.
1994: Riutta A; Alanko J; Mucha I; Vapaatalo H
Effects of Trolox C and SIN-1 on arachidonic acid metabolism and on cyclic GMP formation in leukocytes.
European journal of pharmacology 1994;262(3):217-22.
1994: Riutta A; Nurmi E; Weber C; Hansson G; Vapaatalo H; Mucha I
Selective solid-phase extraction of urinary 2,3-dinor-6-ketoprostaglandin F1 alpha for determination with radioimmunoassay.
Analytical biochemistry 1994;220(2):351-9.
1994: Mervaala E M; Laakso J; Vapaatalo H; Karppanen H
Improvement of cardiovascular effects of metoprolol by replacement of common salt with a potassium- and magnesium-enriched salt alternative.
British journal of pharmacology 1994;112(2):640-8.
1994: Mäkynen H; Arvola P; Vapaatalo H; Pörsti I
High calcium diet effectively opposes the development of deoxycorticosterone-salt hypertension in rats.
American journal of hypertension 1994;7(6):520-8.
1994: Vuorinen P; Wu X; Arvola P; Vapaatalo H; Pörsti I
Effects of P1 and P2Y purinoceptor antagonists on endothelium-dependent and -independent relaxations of rat mesenteric artery to GTP and guanosine.
British journal of pharmacology 1994;112(1):71-4.
1994: Mervaala E M; Paakkari I; Laakso J; Nevala R; Teräväinen T M; Fyhrquist F; Vapaatalo H; Karppanen H
Replacement of salt by a novel potassium- and magnesium-enriched salt alternative improves the cardiovascular effects of ramipril.
British journal of pharmacology 1994;111(4):1189-97.
1994: Wuorela H; Arvola P; Kähönen M; Vapaatalo H; Pörsti I
Arterial smooth muscle responses in adult and moderately aged spontaneously hypertensive rats.
Pharmacology & toxicology 1994;74(3):167-73.
1994: Manninen A; Vuorinen P; Laippala P; Tuimala R; Vapaatalo H
Atrial natriuretic peptide and cyclic guanosine-3'5'-monophosphate in hypertensive pregnancy and during nifedipine treatment.
Pharmacology & toxicology 1994;74(3):153-7.
1994: Vapaatalo H
Tolfenamic acid and migraine--aspects on prostaglandins and leukotrienes.
Pharmacology & toxicology 1994;75 Suppl 2():76-80.
1993: Saareks V; Riutta A; Mucha I; Alanko J; Vapaatalo H
Nicotine and cotinine modulate eicosanoid production in human leukocytes and platelet rich plasma.
European journal of pharmacology 1993;248(4):345-9.
1993: Moilanen E; Kirkkola A L; Kankaanranta H; Nieminen M M; Vapaatalo H
Interactions between synthesis of platelet-activating factor and leukotriene B4 in isolated human polymorphonuclear leukocytes.
Inflammation 1993;17(6):705-14.
1993: Arvola P; Kähönen M; Mäkynen H; Wuorela H; Manninen V; Vapaatalo H; Pörsti I
High calcium diet, different antihypertensive agents, and cytosolic free Ca2+ in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 1993;22(5):702-5.
1993: Kähönen M; Arvola P; Vapaatalo H; Pörsti I
Comparison of cumulative and non-cumulative administration of vasoactive agents in arterial smooth muscle responses in vitro.
Pharmacology & toxicology 1993;73(3):142-5.
1993: Kankaanranta H; Moilanen E; Vapaatalo H
Comparison of in vitro effects of flunixin and tolfenamic acid on human leukocyte and platelet functions.
Inflammation 1993;17(4):417-25.
1993: Moilanen E; Vuorinen P; Kankaanranta H; Metsä-Ketelä T; Vapaatalo H
Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions.
British journal of pharmacology 1993;109(3):852-8.
1993: Asmawi M Z; Kankaanranta H; Moilanen E; Vapaatalo H
Anti-inflammatory activities of Emblica officinalis Gaertn leaf extracts.
The Journal of pharmacy and pharmacology 1993;45(6):581-4.
1993: Arvola P; Ruskoaho H; Wuorela H; Pekki A; Vapaatalo H; Pörsti I
Quinapril treatment and arterial smooth muscle responses in spontaneously hypertensive rats.
British journal of pharmacology 1993;108(4):980-90.
1993: Alanko J; Riutta A; Mucha I; Vapaatalo H; Metsä-Ketelä T
Modulation of arachidonic acid metabolism by phenols: relation to positions of hydroxyl groups and peroxyl radical scavenging properties.
Free radical biology & medicine 1993;14(1):19-25.
1992: Alanko J; Riutta A; Vapaatalo H
Effects of catecholamines on eicosanoid synthesis with special reference to prostanoid/leukotriene ratio.
Free radical biology & medicine 1992;13(6):677-88.
1992: Wuorela H; Pörsti I; Arvola P; Mäkynen H; Vapaatalo H
Three levels of dietary calcium-effects on blood pressure and electrolyte balance in spontaneously hypertensive rats.
Naunyn-Schmiedeberg's archives of pharmacology 1992;346(5):542-9.
1992: Nieminen M M; Moilanen E K; Koskinen M O; Karvonen J I; Tuomisto L; Metsä-Ketelä T J; Vapaatalo H
Inhaled budesonide fails to inhibit the PAF-induced increase in plasma leukotriene B4 in man.
British journal of clinical pharmacology 1992;33(6):645-52.
1992: Riutta A; Mucha I; Vapaatalo H
Solid-phase extraction of urinary 11-dehydrothromboxane B2 for reliable determination with radioimmunoassay.
Analytical biochemistry 1992;202(2):299-305.
1992: Arvola P; Pörsti I; Vuorinen P; Pekki A; Vapaatalo H
Contractions induced by potassium-free solution and potassium relaxation in vascular smooth muscle of hypertensive and normotensive rats.
British journal of pharmacology 1992;106(1):157-65.
1992: Arvola P; Pörsti I; Vuorinen P; Huhtala H; Metsä-Ketelä T; Vapaatalo H
L-cysteine augments the vasorelaxation induced by sodium nitrite and SIN-1 but not that due to acetylcholine.
European journal of pharmacology 1992;214(2-3):289-92.
1992: Vuorinen P; Pörsti I; Metsä-Ketelä T; Manninen V; Vapaatalo H; Laustiola K E
Endothelium-dependent and -independent effects of exogenous ATP, adenosine, GTP and guanosine on vascular tone and cyclic nucleotide accumulation of rat mesenteric artery.
British journal of pharmacology 1992;105(2):279-84.
1992: Pörsti I; Arvola P; Wuorela H; Vapaatalo H
High calcium diet augments vascular potassium relaxation in hypertensive rats.
Hypertension 1992;19(1):85-92.
1992: Wuorela H; Arvola P; Pörsti I; Siltaloppi E; Säynävälammi P; Vapaatalo H
The effect of high calcium intake on Ca2+ ATPase and the tissue Na:K ratio in spontaneously hypertensive rats.
Naunyn-Schmiedeberg's archives of pharmacology 1992;345(1):117-22.
1992: Alanko J; Riutta A; Mucha I; Kerttula T; Kaukinen S; Vapaatalo H; Metsä-Ketelä T; Seppälä E
Adrenaline stimulates thromboxane and inhibits leukotriene synthesis in man.
Eicosanoids 1992;5(3-4):169-75.
1991: Vuorinen P; Pörsti I; Metsä-Ketelä T; Manninen V; Vapaatalo H; Laustiola K E
Modification of nitrovasodilator effects on vascular smooth muscle by exogenous GTP and guanosine.
Journal of cardiovascular pharmacology 1991;18(6):871-7.
1991: Alanko J; Riutta A; Vapaatalo H; Mucha I
Catecholamines decrease leukotriene B4 and increase thromboxane B2 synthesis in A23187-stimulated human whole blood.
Prostaglandins 1991;42(3):279-87.
1991: Manninen A; Metsä-Ketelä T; Tuimala R; Vapaatalo H
Nifedipine increases urinary excretion of prostacyclin metabolite in hypertensive pregnancy.
Pharmacology & toxicology 1991;69(1):60-3.
1991: Numminen H; Hillbom M; Vapaatalo H; Seppälä E; Laustiola K; Benthin G; Muuronen A; Kaste M
Effects of exercise and ethanol ingestion on platelet thromboxane release in healthy men.
Metabolism: clinical and experimental 1991;40(7):695-701.
1991: Nieminen M M; Moilanen E K; Nyholm J-E; Koskinen M O; Karvonen J I; Metsä-Ketelä T J; Vapaatalo H
Platelet-activating factor impairs mucociliary transport and increases plasma leukotriene B4 in man.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1991;4(5):551-60.
1991: Kankaanranta H; Moilanen E; Vapaatalo H
Tolfenamic acid inhibits leukotriene B4-induced chemotaxis of polymorphonuclear leukocytes in vitro.
Inflammation 1991;15(2):137-43.
1991: Pörsti I; Wuorela H; Arvola P; Mämmi P; Nurmi A K; Koistinaho J; Laippala P; Vapaatalo H
Effects of calcium supplementation and deoxycorticosterone on plasma atrial natriuretic peptide and electrolyte excretion in spontaneously hypertensive rats.
Acta physiologica Scandinavica 1991;141(3):343-50.
1991: Vuorinen P; Takalo R; Laustiola K; Manninen V; Vapaatalo H; Metsä-Ketelä T
Exogenous GTP enhances sodium nitrite induced cyclic GMP accumulation in spontaneously beating rat atria.
Pharmacology & toxicology 1991;68(2):149-50.
1991: Ylitalo P; Ylihakola M; Elo H A; Koponen H M; Seppälä E; Vapaatalo H
Inhibition of platelet aggregation and thromboxane A2 production by chlorophenoxy acid herbicides.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1991;14():174-8.
1990: Pörsti I; Arvola P; Wuorela H; Ilkka M; Säynävälammi P; Huhtala H; Metsä-Ketelä T; Vapaatalo H
Effects of a high calcium diet and deoxycorticosterone on vascular smooth muscle responses in spontaneously hypertensive rats.
Journal of hypertension 1990;8(9):835-41.
1990: Parantainen J; Alanko J; Moilanen E; Metsä-Ketelä T; Asmawi M Z; Vapaatalo H
Catecholamines inhibit leukotriene formation and decrease leukotriene/prostaglandin ratio.
Biochemical pharmacology 1990;40(5):961-6.
1990: Ylitalo P; Kaukinen S; Reinikainen P; Salenius J P; Vapaatalo H
A randomized, double-blind, crossover comparison of iloprost with dextran in patients with peripheral arterial occlusive disease.
International journal of clinical pharmacology, therapy, and toxicology 1990;28(5):197-204.
1990: Siitonen S; Vapaatalo H; Salminen S; Gordin A; Saxelin M; Wikberg R; Kirkkola A L
Effect of Lactobacillus GG yoghurt in prevention of antibiotic associated diarrhoea.
Annals of medicine 1990;22(1):57-9.
1990: Wuorela H; Pörsti I; Siltaloppi E; Arvola P; Nurmi A K; Säynävälammi P; Vapaatalo H
Deoxycorticosterone prevents the blood pressure-lowering effect of calcium in spontaneously hypertensive rats.
Methods and findings in experimental and clinical pharmacology 1990;12(1):37-42.
1990: Pentikäinen P J; Voutilainen E; Aro A; Uusitupa M; Penttilä I; Vapaatalo H
Cholesterol lowering effect of metformin in combined hyperlipidemia: placebo controlled double blind trial.
Annals of medicine 1990;22(5):307-12.
1990: Pörsti I; Wuorela H; Arvola P; Säynävälammi P; Nurmi A K; Huhtala H; Laippala P; Metsä-Ketelä T; Vapaatalo H
Effects of calcium and deoxycorticosterone on blood pressure, plasma renin activity and vascular reactivity in spontaneously hypertensive rats.
Clinical and experimental hypertension. Part A, Theory and practice 1990;12(7):1159-74.
1990: Pörsti I; Arvola P; Säynävälammi P; Nurmi A K; Metsä-Ketelä T; Koskenvuo K; Laitinen L A; Manninen V; Vapaatalo H
Effects of single doses of quinapril and atenolol on autonomic nervous function and exercise capacity in healthy volunteers.
European journal of clinical pharmacology 1990;38(6):541-6.
1990: Seppälä E; Nissilä M; Isomäki H; Wuorela H; Vapaatalo H
Effects of non-steroidal anti-inflammatory drugs and prednisolone on synovial fluid white cells, prostaglandin E2, leukotriene B4 and cyclic AMP in patients with rheumatoid arthritis.
Scandinavian journal of rheumatology 1990;19(1):71-5.
1990: Manninen A K; Tuimala R; Vapaatalo H
Blood pressure, plasma renin activity and calcium metabolism in hypertensive pregnancy: the effect of nifedipine.
International journal of clinical pharmacology research 1990;10(6):331-7.
1989: Moilanen E; Alanko J; Nissilä M; Hämäläinen M; Isomäki H; Vapaatalo H
Eicosanoid production in rheumatoid synovitis.
Agents and actions 1989;28(3-4):290-7.
1989: Moilanen E; Alanko J; Juhakoski A; Vapaatalo H
Orally administered tolfenamic acid inhibits leukotriene synthesis in isolated human peripheral polymorphonuclear leukocytes.
Agents and actions 1989;28(1-2):83-8.
1989: Stenius-Aarniala B; Aro A; Hakulinen A; Ahola I; Seppälä E; Vapaatalo H
Evening primose oil and fish oil are ineffective as supplementary treatment of bronchial asthma.
Annals of allergy 1989;62(6):534-7.
1989: Neuvonen P J; Kuusisto P; Manninen V; Vapaatalo H; Miettinen T A
The mechanism of the hypocholesterolaemic effect of activated charcoal.
European journal of clinical investigation 1989;19(3):251-4.
1989: Arvola P; Nurmi A K; Säynävälammi P; Manninen V; Vapaatalo H
Blood pressure responses to enalapril in rats with one- and two-kidney DOC-NaCl hypertension.
Methods and findings in experimental and clinical pharmacology 1989;11(2):67-71.
1989: Alanko J; Moilanen E; Opas J; Vapaatalo H
Tolfenamic acid inhibits leukotriene synthesis in human granulocytes.
Agents and actions 1989;26(1-2):254-5.
1989: Neuvonen P J; Kuusisto P; Vapaatalo H; Manninen V
Activated charcoal in the treatment of hypercholesterolaemia: dose-response relationships and comparison with cholestyramine.
European journal of clinical pharmacology 1989;37(3):225-30.
1988: Moilanen E; Alanko J; Seppälä E; Vapaatalo H
Effects of antirheumatic drugs on leukotriene B4 and prostanoid synthesis in human polymorphonuclear leukocytes in vitro.
Agents and actions 1988;24(3-4):387-94.
1988: Säynävälammi P; Pörsti I; Pörsti P; Nurmi A K; Seppälä E; Manninen V; Vapaatalo H
Effects of the converting enzyme inhibitor quinapril (CI-906) on blood pressure, renin-angiotensin system, and prostanoids in essential hypertension.
Journal of cardiovascular pharmacology 1988;12(1):88-93.
1988: Vapaatalo H; Tuomisto M; Turjanmaa V; Metsä-Ketelä T; Fredrikson M; Uusitalo A
Plasma catecholamines and production of thromboxane B2 by platelets after psychological and physical tests in normotensive and mild hypertensive subjects.
Biomedica biochimica acta 1988;47(10-11):S294-8.
1988: Seppälä E; Lehtinen K; Isomäki H; Nissilä M; Harmoinen A; Mörsky P; Koivula T; Vapaatalo H
Effects of long-term aurothiomalate and D-penicillamine treatments on renal function and urinary excretion of prostanoids in patients with rheumatoid arthritis.
International journal of clinical pharmacology research 1988;8(3):149-56.
1988: Moilanen E; Alanko J; Asmawi M Z; Vapaatalo H
CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro.
Eicosanoids 1988;1(1):35-9.
1987: Antonen J; Ranki A; Valle S L; Seppälä E; Vapaatalo H; Suni J; Krohn K
The validity of immunological studies in human immunodeficiency virus infection: a three-year follow-up of 235 homo- or bisexual persons.
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology 1987;95(6):275-82.
1987: Ala-Houhala I; Vapaatalo H; Pasternack A
Intravenously administered frusemide increases glomerular permeability.
Clinical science (London, England : 1979) 1987;73(4):365-70.
1987: Säynävälammi P; Arvola P; Kuismanen K; Seppälä E; Nurmi A K; Manninen V; Vapaatalo H
Effects of indomethacin on hormonal and blood pressure responses to captopril in spontaneously hypertensive rats.
Pharmacology & toxicology 1987;61(3):195-8.
1987: Moilanen E; Alanko J; Seppälä E; Nissilä M; Isomäki H; Vapaatalo H
Antirheumatic drugs and eicosanoid synthesis.
Scandinavian journal of rheumatology. Supplement 1987;67():10-6.
1986: Laustiola K; Kaukinen S; Seppälä E; Jokela T; Vapaatalo H
Adrenaline infusion evokes increased thromboxane B2 production by platelets in healthy men: the effect of beta-adrenoceptor blockade.
European journal of clinical investigation 1986;16(6):473-9.
1986: Pörsti I; Säynävälammi P; Arvola P; Nurmi A K; Manninen V; Ylitalo P; Vapaatalo H
Effects of two structurally different angiotensin-converting enzyme inhibitors, captopril and quinapril (CI-906), in rats with one-kidney deoxycorticosterone-salt hypertension.
Methods and findings in experimental and clinical pharmacology 1986;8(9):543-6.
1986: Säynävälammi P; Pörsti I; Nurmi A K; Seppälä E; Metsä-Ketelä T; Tuomisto L; Manninen V; Vapaatalo H
Inhibition of angiotensin-converting enzyme with quinapril (CI-906): investigation of antihypertensive mechanisms in spontaneously hypertensive rats.
The Journal of pharmacology and experimental therapeutics 1986;237(1):246-51.
1985: Laustiola K; Seppälä E; Vuorinen P; Salo M; Uusitalo A; Vapaatalo H
The effect of pindolol on exercise-induced increase in plasma vasoactive prostanoids and catecholamines in healthy men.
Prostaglandins, leukotrienes, and medicine 1985;20(2):111-20.
1985: Ylitalo P; Pitkäjärvi T; Pyykönen M L; Nurmi A K; Seppälä E; Vapaatalo H
Inhibition of prostaglandin synthesis by indomethacin interacts with the antihypertensive effect of atenolol.
Clinical pharmacology and therapeutics 1985;38(4):443-9.
1985: Ylitalo P; Kaukinen S; Nurmi A K; Seppälä E; Pessi T; Vapaatalo H
Effects of a prostacyclin analog iloprost on kidney function, renin-angiotensin and kallikrein-kinin systems, prostanoids and catecholamines in man.
Prostaglandins 1985;29(6):1063-71.
1985: Hillbom M; Kangasaho M; Kaste M; Numminen H; Vapaatalo H
Acute ethanol ingestion increases platelet reactivity: is there a relationship to stroke?
Stroke; a journal of cerebral circulation 1985;16(1):19-23.
1984: Kaukinen S; Ylitalo P; Pessi T; Vapaatalo H
Hemodynamic effects of iloprost, a prostacyclin analog.
Clinical pharmacology and therapeutics 1984;36(4):464-9.
1984: Laustiola K; Seppälä E; Nikkari T; Vapaatalo H
Exercise-induced increase in plasma arachidonic acid and thromboxane B2 in healthy men: effect of beta-adrenergic blockade.
Journal of cardiovascular pharmacology 1984;6(3):449-54.
1984: Rauramaa R; Salonen J T; Kukkonen-Harjula K; Seppänen K; Seppälä E; Vapaatalo H; Huttunen J K
Effects of mild physical exercise on serum lipoproteins and metabolites of arachidonic acid: a controlled randomised trial in middle aged men.
British medical journal (Clinical research ed.) 1984;288(6417):603-6.
1984: Vapaatalo H; Laustiola K; Seppälä E; Rauramaa R; Kaste M; Hillbom M; Kangasaho M
Exercise, ethanol and arachidonic acid metabolism in healthy men.
Biomedica biochimica acta 1984;43(8-9):S413-20.
1984: Vapaatalo H; Ylitalo P; Säynävälammi P; Seppälä E; Puska P
Prostanoids in blood pressure regulation and their role in the blood pressure lowering effects induced by changes in dietary fats.
Annals of clinical research 1984;16 Suppl 43():109-15.
1984: Säynävälammi P; Pörsti I; Nurmi A K; Seppälä E; Laitinen L A; Manninen V; Ylitalo P; Vapaatalo H
Differing effects of two angiotensin converting enzyme inhibitors, captopril and CI-906, on diuresis and the urinary excretion of kallikrein and prostaglandins in spontaneously hypertensive rats.
Scandinavian journal of urology and nephrology. Supplementum 1984;79():23-7.
1984: Ylitalo P; Kaukinen S; Seppäla E; Nurmi A K; Pessi T; Krais T; Vapaatalo H
Pharmacological effects of iloprost (ZK 36 374), a stable prostacyclin analogue, in man.
Biomedica biochimica acta 1984;43(8-9):S399-402.
1983: Laustiola K; Uusitalo A; Koivula T; Sovijärvi A; Seppälä E; Nikkari T; Vapaatalo H
Divergent effects of atenolol, practolol and propranolol on the peripheral metabolic changes induced by dynamic exercise in healthy men.
European journal of clinical pharmacology 1983;25(3):293-7.
1983: Kangasaho M; Hillbom M; Kaste M; Wuorela H; Vapaatalo H
Formation of thromboxane B2 by platelets and concentrations of thromboxane B2 and 6-keto-prostaglandin F1 alpha in plasma after acute ethanol ingestion.
Advances in prostaglandin, thromboxane, and leukotriene research 1983;12():223-8.
1982: Kangasaho M; Hillbom M; Kaste M; Vapaatalo H
Effects of ethanol intoxication and hangover on plasma levels of thromboxane B2 and 6-keto-prostaglandin F1 alpha and on thromboxane B2 formation by platelets in man.
Thrombosis and haemostasis 1982;48(2):232-4.
1982: Säynävälammi P; Vaalasti A; Pyykönen M L; Ylitalo P; Vapaatalo H
The effect of renal sympathectomy on blood pressure and plasma renin activity in spontaneously hypertensive and normotensive rats.
Acta physiologica Scandinavica 1982;115(3):289-93.
1981: Metsä-Ketelä T; Parantainen J; Vapaatalo H
Load-dependent activation of calcium turnover and cardiac performance in isolated rat atria.
Acta physiologica Scandinavica 1981;111(3):259-62.
1980: Metsä-Ketelä T; Parantainen J; Vapaatalo H
Effects of prostaglandins on gastric acid and mucus secretion.
Advances in prostaglandin and thromboxane research 1980;8():1553-6.

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