Gabriele Varani

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Olsen Greg L; Bardaro Michael F; Echodu Dorothy C; Drobny Gary P; Varani Gabriele
Hydration dependent dynamics in RNA.
Davidson Amy; Leeper Thomas C; Athanassiou Zafiria; Patora-Komisarska Krystyna; Karn Jonathan; Robinson John A; Varani Gabriele
Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein.
Godin Katherine S; Walbott Hélène; Leulliot Nicolas; van Tilbeurgh Herman; Varani Gabriele
The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme.

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All Publications

2009: Olsen Greg L; Bardaro Michael F; Echodu Dorothy C; Drobny Gary P; Varani Gabriele
Hydration dependent dynamics in RNA.
Journal of biomolecular NMR 2009;45(1-2):133-42.
2009: Davidson Amy; Leeper Thomas C; Athanassiou Zafiria; Patora-Komisarska Krystyna; Karn Jonathan; Robinson John A; Varani Gabriele
Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):11931-6.
2009: Godin Katherine S; Walbott Hélène; Leulliot Nicolas; van Tilbeurgh Herman; Varani Gabriele
The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme.
Journal of molecular biology 2009;390(2):231-44.
2009: Zheng Suxin; Chen Yu; Donahue Christine P; Wolfe Michael S; Varani Gabriele
Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone).
Chemistry & biology 2009;16(5):557-66.
2009: Bardaro Michael F; Shajani Zahra; Patora-Komisarska Krystyna; Robinson John A; Varani Gabriele
How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape.
Nucleic acids research 2009;37(5):1529-40.
2008: Echodu Dorothy; Goobes Gil; Shajani Zahra; Pederson Kari; Meints Gary; Varani Gabriele; Drobny Gary
Furanose dynamics in the HhaI methyltransferase target DNA studied by solution and solid-state NMR relaxation.
The journal of physical chemistry. B 2008;112(44):13934-44.
2008: Chen Yu; Mandic Jana; Varani Gabriele
Cell-free selection of RNA-binding proteins using in vitro compartmentalization.
Nucleic acids research 2008;36(19):e128.
2008: Gherghe Costin M; Shajani Zahra; Wilkinson Kevin A; Varani Gabriele; Weeks Kevin M
Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA.
Journal of the American Chemical Society 2008;130(37):12244-5.
2008: Shajani Zahra; Varani Gabriele
13C relaxation studies of the DNA target sequence for hhai methyltransferase reveal unique motional properties.
Biochemistry 2008;47(29):7617-25.
2008: Reichow Steve L; Varani Gabriele
Nop10 is a conserved H/ACA snoRNP molecular adaptor.
Biochemistry 2008;47(23):6148-56.
2008: Liu Jiyun; Begley Darren; Mitchell Daniel D; Verlinde Christophe L M J; Varani Gabriele; Fan Erkang
Multivalent drug design and inhibition of cholera toxin by specific and transient protein-ligand interactions.
Chemical biology & drug design 2008;71(5):408-19.
2008: Olsen Greg L; Echodu Dorothy C; Shajani Zahra; Bardaro Michael F; Varani Gabriele; Drobny Gary P
Solid-state deuterium NMR studies reveal micros-ns motions in the HIV-1 transactivation response RNA recognition site.
Journal of the American Chemical Society 2008;130(10):2896-7.
2008: Deka Pritilekha; Bucheli Miriam E; Moore Claire; Buratowski Stephen; Varani Gabriele
Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals.
Journal of molecular biology 2008;375(1):136-50.
2007: Zheng Suxin; Robertson Timothy A; Varani Gabriele
A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins.
The FEBS journal 2007;274(24):6378-91.
2007: Godin Katherine S; Varani Gabriele
How arginine-rich domains coordinate mRNA maturation events.
RNA biology 2007;4(2):69-75.
2007: Leulliot Nicolas; Godin Katherine S; Hoareau-Aveilla Coralie; Quevillon-Cheruel Sophie; Varani Gabriele; Henry Yves; Van Tilbeurgh Herman
The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p.
Journal of molecular biology 2007;371(5):1338-53.
2007: Shajani Zahra; Varani Gabriele
NMR studies of dynamics in RNA and DNA by 13C relaxation.
Biopolymers 2007;86(5-6):348-59.
2007: Lunde Bradley M; Moore Claire; Varani Gabriele
RNA-binding proteins: modular design for efficient function.
Nature reviews. Molecular cell biology 2007;8(6):479-90.
2007: Shajani Zahra; Drobny Gary; Varani Gabriele
Binding of U1A protein changes RNA dynamics as observed by 13C NMR relaxation studies.
Biochemistry 2007;46(20):5875-83.
2007: Dantas Gautam; Corrent Colin; Reichow Steve L; Havranek James J; Eletr Ziad M; Isern Nancy G; Kuhlman Brian; Varani Gabriele; Merritt Ethan A; Baker David
High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design.
Journal of molecular biology 2007;366(4):1209-21.
2007: Watters Alexander L; Deka Pritilekha; Corrent Colin; Callender David; Varani Gabriele; Sosnick Tobin; Baker David
The highly cooperative folding of small naturally occurring proteins is likely the result of natural selection.
Cell 2007;128(3):613-24.
2007: Mudeppa Devaraja G; Pang Cullen K T; Tsuboi Takafumi; Endo Yaeta; Buckner Fredrick S; Varani Gabriele; Rathod Pradipsinh K
Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.
Molecular and biochemical parasitology 2007;151(2):216-9.
2007: Robertson Timothy A; Varani Gabriele
An all-atom, distance-dependent scoring function for the prediction of protein-DNA interactions from structure.
Proteins 2007;66(2):359-74.
2007: Athanassiou Zafiria; Patora Krystyna; Dias Ricardo L A; Moehle Kerstin; Robinson John A; Varani Gabriele
Structure-guided peptidomimetic design leads to nanomolar beta-hairpin inhibitors of the Tat-TAR interaction of bovine immunodeficiency virus.
Biochemistry 2007;46(3):741-51.
2007: Moehle Kerstin; Athanassiou Zafiria; Patora Krystyna; Davidson Amy; Varani Gabriele; Robinson John A
Design of beta-hairpin peptidomimetics that inhibit binding of alpha-helical HIV-1 Rev protein to the rev response element RNA.
Angewandte Chemie (International ed. in English) 2007;46(47):9101-4.
2007: Reichow Steve L; Hamma Tomoko; Ferré-D'Amaré Adrian R; Varani Gabriele
The structure and function of small nucleolar ribonucleoproteins.
Nucleic acids research 2007;35(5):1452-64.
2006: Miller Paul A; Shajani Zahra; Meints Gary A; Caplow Dorothy; Goobes Gil; Varani Gabriele; Drobny Gary P
Contrasting views of the internal dynamics of the HhaI methyltransferase target DNA reported by solution and solid-state NMR spectroscopy.
Journal of the American Chemical Society 2006;128(50):15970-1.
2006: Dantas Gautam; Watters Alexander L; Lunde Bradley M; Eletr Ziad M; Isern Nancy G; Roseman Toby; Lipfert Jan; Doniach Sebastian; Tompa Martin; Kuhlman Brian; Stoddard Barry L; Varani Gabriele; Baker David
Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution.
Journal of molecular biology 2006;362(5):1004-24.
2006: Shajani Zahra; Deka Pritilekha; Varani Gabriele
Decoding RNA motional codes.
Trends in biochemical sciences 2006;31(8):421-4.
2006: Chen Yu; Fender Jessica; Legassie Jason D; Jarstfer Michael B; Bryan Tracy M; Varani Gabriele
Structure of stem-loop IV of Tetrahymena telomerase RNA.
The EMBO journal 2006;25(13):3156-66.
2006: Dobson Neil; Dantas Gautam; Baker David; Varani Gabriele
High-resolution structural validation of the computational redesign of human U1A protein.
Structure (London, England : 1993) 2006;14(5):847-56.
2005: Hamma Tomoko; Reichow Steve L; Varani Gabriele; Ferré-D'Amaré Adrian R
The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs.
Nature structural & molecular biology 2005;12(12):1101-7.
2005: Hunt Sonia Y; Detering Carsten; Varani Gabriele; Jacobus David P; Schiehser Guy A; Shieh Hong-Ming; Nevchas Isabelle; Terpinski Jacek; Sibley Carol Hopkins
Identification of the optimal third generation antifolate against P. falciparum and P. vivax.
Molecular and biochemical parasitology 2005;144(2):198-205.
2005: Dobson Neil; Dantas Gautam; Varani Gabriele
1H, 13C and 15N resonance assignments of URNdesign, a computationally redesigned RRM protein.
Journal of biomolecular NMR 2005;33(2):135.
2005: Leeper Thomas C; Athanassiou Zafiria; Dias Ricardo L A; Robinson John A; Varani Gabriele
TAR RNA recognition by a cyclic peptidomimetic of Tat protein.
Biochemistry 2005;44(37):12362-72.
2005: Pang Cullen K T; De Surya Kanta; White John; Buckner Frederick S; Varani Gabriele; Rathod Pradipsinh K
Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase.
Molecular and biochemical parasitology 2005;143(1):121-4.
2005: Shajani Zahra; Varani Gabriele
13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein.
Journal of molecular biology 2005;349(4):699-715.
2005: Chen Yu; Varani Gabriele
Protein families and RNA recognition.
The FEBS journal 2005;272(9):2088-97.
2005: Deka Pritilekha; Rajan P K; Perez-Canadillas Jose Manuel; Varani Gabriele
Protein and RNA dynamics play key roles in determining the specific recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein.
Journal of molecular biology 2005;347(4):719-33.
2005: Leeper Thomas C; Varani Gabriele
The structure of an enzyme-activating fragment of human telomerase RNA.
RNA (New York, N.Y.) 2005;11(4):394-403.
2005: Olsen Greg L; Edwards Thomas E; Deka Pritilekha; Varani Gabriele; Sigurdsson Snorri Th; Drobny Gary P
Monitoring tat peptide binding to TAR RNA by solid-state 31P-19F REDOR NMR.
Nucleic acids research 2005;33(11):3447-54.
2004: Leulliot Nicolas; Quevillon-Cheruel Sophie; Graille Marc; van Tilbeurgh Herman; Leeper Thomas C; Godin Katherine S; Edwards Thomas E; Sigurdsson Snorri T L; Rozenkrants Natasha; Nagel Roland J; Ares Manuel; Varani Gabriele
A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III.
The EMBO journal 2004;23(13):2468-77.
2004: Athanassiou Zafiria; Dias Ricardo L A; Moehle Kerstin; Dobson Neil; Varani Gabriele; Robinson John A
Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements.
Journal of the American Chemical Society 2004;126(22):6906-13.
2004: Chen Yu; Kortemme Tanja; Robertson Tim; Baker David; Varani Gabriele
A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminates decoys.
Nucleic acids research 2004;32(17):5147-62.
2004: Varani Gabriele; Chen Yu; Leeper Thomas C
NMR studies of protein-nucleic acid interactions.
Methods in molecular biology (Clifton, N.J.) 2004;278():289-312.
2003: Kuhlman Brian; Dantas Gautam; Ireton Gregory C; Varani Gabriele; Stoddard Barry L; Baker David
Design of a novel globular protein fold with atomic-level accuracy.
Science (New York, N.Y.) 2003;302(5649):1364-8.
2003: Pérez Cañadillas José Manuel; Varani Gabriele
Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein.
The EMBO journal 2003;22(11):2821-30.
2003: Leeper Thomas; Leulliot Nicolas; Varani Gabriele
The solution structure of an essential stem-loop of human telomerase RNA.
Nucleic acids research 2003;31(10):2614-21.
2002: Greatorex Jane; Gallego José; Varani Gabriele; Lever Andrew
Structure and stability of wild-type and mutant RNA internal loops from the SL-1 domain of the HIV-1 packaging signal.
Journal of molecular biology 2002;322(3):543-57.
2001: Leulliot N; Varani G
Current topics in RNA-protein recognition: control of specificity and biological function through induced fit and conformational capture.
Biochemistry 2001;40(27):7947-56.
2001: Varani G
Delivering messages from the 3' end.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4288-9.
2001: Pérez-Cañadillas J M; Varani G
Recent advances in RNA-protein recognition.
Current opinion in structural biology 2001;11(1):53-8.
2001: Allen M; Varani L; Varani G
Nuclear magnetic resonance methods to study structure and dynamics of RNA-protein complexes.
Methods in enzymology 2001;339():357-76.
2000: Varani G; McClain W H
The G x U wobble base pair. A fundamental building block of RNA structure crucial to RNA function in diverse biological systems.
EMBO reports 2000;1(1):18-23.
2000: Varani L; Gunderson S I; Mattaj I W; Kay L E; Neuhaus D; Varani G
The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein.
Nature structural biology 2000;7(4):329-35.
2000: Zeffman A; Hassard S; Varani G; Lever A
The major HIV-1 packaging signal is an extended bulged stem loop whose structure is altered on interaction with the Gag polyprotein.
Journal of molecular biology 2000;297(4):877-93.
2000: Ramos A; Grünert S; Adams J; Micklem D R; Proctor M R; Freund S; Bycroft M; St Johnston D; Varani G
RNA recognition by a Staufen double-stranded RNA-binding domain.
The EMBO journal 2000;19(5):997-1009.
2000: Varani L; Spillantini M G; Goedert M; Varani G
Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics.
Nucleic acids research 2000;28(3):710-9.
2000: Bayer P; Varani L; Varani G
Nuclear magnetic resonance methods to study RNA-protein complexes.
Methods in enzymology 2000;317():198-220.
1999: Mittermaier A; Varani L; Muhandiram D R; Kay L E; Varani G
Changes in side-chain and backbone dynamics identify determinants of specificity in RNA recognition by human U1A protein.
Journal of molecular biology 1999;294(4):967-79.
1999: Chang K Y; Varani G; Bhattacharya S; Choi H; McClain W H
Correlation of deformability at a tRNA recognition site and aminoacylation specificity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11764-9.
1999: Varani L; Hasegawa M; Spillantini M G; Smith M J; Murrell J R; Ghetti B; Klug A; Goedert M; Varani G
Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8229-34.
1999: Bayer P; Varani L; Varani G
Refinement of the structure of protein-RNA complexes by residual dipolar coupling analysis.
Journal of biomolecular NMR 1999;14(2):149-55.
1999: Ramos A; Bayer P; Varani G
Determination of the structure of the RNA complex of a double-stranded RNA-binding domain from Drosophila Staufen protein.
Biopolymers 1999;52(4):181-96.
1998: Howe P W; Allain F H; Varani G; Neuhaus D
Determination of the NMR structure of the complex between U1A protein and its RNA polyadenylation inhibition element.
Journal of biomolecular NMR 1998;11(1):59-84.
1998: Varani G; Nagai K
RNA recognition by RNP proteins during RNA processing.
Annual review of biophysics and biomolecular structure 1998;27():407-45.
1997: Chang K Y; Varani G
Nucleic acids structure and recognition.
Nature structural biology 1997;4 Suppl():854-8.
1997: Allain F H; Howe P W; Neuhaus D; Varani G
Structural basis of the RNA-binding specificity of human U1A protein.
The EMBO journal 1997;16(18):5764-72.
1997: Varani G
A cap for all occasions.
Structure (London, England : 1993) 1997;5(7):855-8.
1997: Ramos A; Gubser C C; Varani G
Recent solution structures of RNA and its complexes with drugs, peptides and proteins.
Current opinion in structural biology 1997;7(3):317-23.
1997: Ramos A; Varani G
Structure of the acceptor stem of Escherichia coli tRNA Ala: role of the G3.U70 base pair in synthetase recognition.
Nucleic acids research 1997;25(11):2083-90.
1997: Allain F H; Varani G
How accurately and precisely can RNA structure be determined by NMR?
Journal of molecular biology 1997;267(2):338-51.
1996: Aboul-ela F; Karn J; Varani G
Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge.
Nucleic acids research 1996;24(20):3974-81.
1996: Allain F H; Gubser C C; Howe P W; Nagai K; Neuhaus D; Varani G
Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation.
Nature 1996;380(6575):646-50.
1996: Avis J M; Allain F H; Howe P W; Varani G; Nagai K; Neuhaus D
Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding.
Journal of molecular biology 1996;257(2):398-411.
1996: Gubser C C; Varani G
Structure of the polyadenylation regulatory element of the human U1A pre-mRNA 3'-untranslated region and interaction with the U1A protein.
Biochemistry 1996;35(7):2253-67.
1995: Aboul-ela F; Karn J; Varani G
The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein.
Journal of molecular biology 1995;253(2):313-32.
1995: Allain F H; Varani G
Structure of the P1 helix from group I self-splicing introns.
Journal of molecular biology 1995;250(3):333-53.
1995: Varani G; Aboul-ela F; Allain F; Gubser C C
Novel three-dimensional 1H-13C-31P triple resonance experiments for sequential backbone correlations in nucleic acids.
Journal of biomolecular NMR 1995;5(3):315-20.
1995: Allain F H; Varani G
Divalent metal ion binding to a conserved wobble pair defining the upstream site of cleavage of group I self-splicing introns.
Nucleic acids research 1995;23(3):341-50.
1995: Aboul-ela F; Varani G
Novel techniques in nuclear magnetic resonance for nucleic acids.
Current opinion in biotechnology 1995;6(1):89-95.
1995: Varani G
Exceptionally stable nucleic acid hairpins.
Annual review of biophysics and biomolecular structure 1995;24():379-404.
1994: Howe P W; Nagai K; Neuhaus D; Varani G
NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein.
The EMBO journal 1994;13(16):3873-81.
1993: Wimberly B; Varani G; Tinoco I
The conformation of loop E of eukaryotic 5S ribosomal RNA.
Biochemistry 1993;32(4):1078-87.
1991: Varani G; Tinoco I
RNA structure and NMR spectroscopy.
Quarterly reviews of biophysics 1991;24(4):479-532.
1991: Varani G; Cheong C; Tinoco I
Structure of an unusually stable RNA hairpin.
Biochemistry 1991;30(13):3280-9.
1990: Cheong C; Varani G; Tinoco I
Solution structure of an unusually stable RNA hairpin, 5'GGAC(UUCG)GUCC.
Nature 1990;346(6285):680-2.
1989: Varani G; Wimberly B; Tinoco I
Conformation and dynamics of an RNA internal loop.
Biochemistry 1989;28(19):7760-72.
1988: Aboul-ela F; Varani G; Walker G T; Tinoco I
The TFIIIA recognition fragment d(GGATGGGAG).d(CTCCCATCC) is B-form in solution.
Nucleic acids research 1988;16(8):3559-72.

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Gabriele Varani

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