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Katia Varani

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Chemicals & Drugs

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Fabrizio Vincenzi; Pier Giovanni Baraldi; Pier Andrea Borea; Carmen Corciulo; Stefania Gessi; Stefania Merighi; Giulia Saponaro; Mojgan Aghazadeh Tabrizi; Martina Targa; Katia Varani
Antinociceptive effects of the selective CB2 agonist MT178 in inflammatory and chronic rodent pain models.
Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Carmen Corciulo; Allan R Moorman; Delia Preti; Romeo Romagnoli; Giulia Saponaro; Fabrizio Vincenzi; Katia Varani
Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.
Fabrizio Vincenzi; Pier Andrea Borea; Carmen Corciulo; Stefania Gessi; Sarah Giacuzzo; Marcello Govoni; Stefania Merighi; Melissa Padovan; Martina Targa; Katia Varani
A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats.

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All Publications

2013: Fabrizio Vincenzi; Pier Giovanni Baraldi; Pier Andrea Borea; Carmen Corciulo; Stefania Gessi; Stefania Merighi; Giulia Saponaro; Mojgan Aghazadeh Tabrizi; Martina Targa; Katia Varani
Antinociceptive effects of the selective CB2 agonist MT178 in inflammatory and chronic rodent pain models.
Pain 2013;154(6):864-73.
2013: Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Carmen Corciulo; Allan R Moorman; Delia Preti; Romeo Romagnoli; Giulia Saponaro; Fabrizio Vincenzi; Katia Varani
Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.
Journal of medicinal chemistry 2013;56(3):1098-112.
2013: Fabrizio Vincenzi; Pier Andrea Borea; Carmen Corciulo; Stefania Gessi; Sarah Giacuzzo; Marcello Govoni; Stefania Merighi; Melissa Padovan; Martina Targa; Katia Varani
A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats.
PloS one 2013;8(1):e54195.
2013: Daniela Catarzi; Vittoria Colotta; Pier Andrea Borea; Diego Dal Ben; Guido Filacchioni; Catia Lambertucci; Daniela Poli; Lucia Squarcialupi; Flavia Varano; Katia Varani; Fabrizio Vincenzi; Gloria Cristalli
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.
Bioorganic & medicinal chemistry 2013;21(1):283-94.
2013: Katia Varani; Fabrizio Vincenzi; Milena Fini; Giovanni Lanza; Beatrice Paradiso; Annapaola Parrilli; Martina Targa; Pier Andrea Borea
The stimulation of A(3) adenosine receptors reduces bone-residing breast cancer in a rat preclinical model.
European journal of cancer (Oxford, England : 1990) 2013;49(2):482-91.
2012: Stefania Gessi; Roberto Marci; Stefania Merighi; Prisco Mirandola; Alberto Sensi; Angela Stefanelli; Katia Varani; Alessandra Bonfatti; Pier Andrea Borea; Sergio Fini; Fortunato Vesce
Downregulation of A(1) and A(2B) adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi.
Biochimica et biophysica acta 2012;1822(11):1660-70.
2012: Stefania Merighi; Katia Varani; Debora Fazzi; Stefania Gessi; Pier Andrea Borea
Hydrogen sulfide modulates the release of nitric oxide and VEGF in human keratinocytes.
Pharmacological research : the official journal of the Italian Pharmacological Society 2012;66(5):428-36.
2012: Romeo Romagnoli; Maria Kimatrai Salvador; Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Pier Andrea Borea; LUISA-CARLOTA LÓPEZ-CARA; Maria Dora Carrion; Olga Cruz-Lopez; Allan R Moorman; Delia Preti; Fabrizio Vincenzi; Katia Varani
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.
Journal of medicinal chemistry 2012;55(17):7719-35.
2012: Silvia Vertuani; Anna Baldisserotto; Pier Andrea Borea; Bonache De Marcos Maria Cruz; Luca Ferraro; Stefano Manfredini; Katia Varani; Alessandro Dalpiaz
Synthesis and in vitro stability of nucleoside 5'-phosphonate derivatives.
European journal of medicinal chemistry 2012;54():202-9.
2012: Stefania Merighi; Prisco Mirandola; Katia Varani; Debora Fazzi; Stefania Gessi; Pier Andrea Borea
Cannabinoid CB(2) receptor attenuates morphine-induced inflammatory responses in activated microglial cells.
British journal of pharmacology 2012;166(8):2371-85.
2012: Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Allan R Moorman; Delia Preti; Romeo Romagnoli; Emanuela Ruggiero; Giulia Saponaro; Martina Targa; Katia Varani; Fabrizio Vincenzi; Mojgan Aghazadeh Tabrizi
7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB(2) cannabinoid receptor ligands: structural investigations around a novel class of full agonists.
Journal of medicinal chemistry 2012;55(14):6608-23.
2012: Pier Giovanni Baraldi; Pier Andrea Borea; Delia Preti; Katia Varani
Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.
Journal of medicinal chemistry 2012;55(12):5676-703.
2012: Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Sandro Cosconati; Salvatore Di Maro; Stefania Gessi; Luciana Marinelli; Stefania Merighi; Allan R Moorman; Romeo Romagnoli; Giulia Saponaro; Katia Varani; Mojgan Aghazadeh Tabrizi; Delia Preti
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists.
Journal of medicinal chemistry 2012;55(11):5380-90.
2012: Alessia Ongaro; Agnese Pellati; Katia Varani; Fabrizio Vincenzi; Pier Andrea Borea; Ruggero Cadossi; A Caruso; M Fini; F F Masieri; Leo Massari; Monica De Mattei
Electromagnetic fields (EMFs) and adenosine receptors modulate prostaglandin E(2) and cytokine release in human osteoarthritic synovial fibroblasts.
Journal of cellular physiology 2012;227(6):2461-9.
2012: Alessandro Dalpiaz; Stephanie Federico; Barbara Pavan; Giampiero Spalluto; Pier Andrea Borea; Fabrizio Bortolotti; Barbara Cacciari; Chiara Beatrice Vicentini; Fabrizio Vincenzi; Katia Varani
A novel conjugated agent between dopamine and an A2A adenosine receptor antagonist as a potential anti-Parkinson multitarget approach.
Molecular pharmaceutics 2012;9(3):591-604.
2012: Stefania Merighi; Prisco Mirandola; Carolina Simioni; Katia Varani; Debora Fazzi; Stefania Gessi; Pier Andrea Borea
Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide.
British journal of pharmacology 2012;165(6):1773-88.
2012: Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Andrea Cavalli; Allan R Moorman; Laura Piccagli; Delia Preti; Maurizio Recanatini; Romeo Romagnoli; Giulia Saponaro; Katia Varani; Abdel Naser Zaid; Mojgan Aghazadeh Tabrizi
Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A₂B adenosine receptor antagonists.
Journal of medicinal chemistry 2012;55(2):797-811.
2012: Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Allan R Moorman; LUISA-CARLOTA LÓPEZ-CARA; Giulia Saponaro; Katia Varani; Mojgan Aghazadeh Tabrizi; Delia Preti
Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2012;20(2):1046-59.
2012: Romeo Romagnoli; Maria Kimatrai Salvador; John C Shryock; Mojgan Aghazadeh Tabrizi; Katia Varani; Fabrizio Vincenzi; LUISA-CARLOTA LÓPEZ-CARA; Maria Dora Carrion; Olga Cruz-Lopez; Allan R Moorman; Delia Preti; Pier Giovanni Baraldi; Pier Andrea Borea
Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A₁ adenosine receptor.
Bioorganic & medicinal chemistry 2012;20(2):996-1007.
2012: Fabrizio Vincenzi; Pier Andrea Borea; Ruggero Cadossi; Carmen Corciulo; Stefania Gessi; Stefania Merighi; Stefania Setti; Martina Targa; Katia Varani
The anti-tumor effect of A3 adenosine receptors is potentiated by pulsed electromagnetic fields in cultured neural cancer cells.
PloS one 2012;7(6):e39317.
2011: Stefania Gessi; Stefania Merighi; Angela Stefanelli; Katia Varani; Debora Fazzi; Pier Andrea Borea
Adenosine receptor targeting in health and disease.
Expert opinion on investigational drugs 2011;20(12):1591-609.
2011: Pier Giovanni Baraldi; Stefania Baraldi; Sandro Cosconati; Salvatore Di Maro; Luciana Marinelli; Allan R Moorman; Ettore Novellino; Delia Preti; LUISA-CARLOTA LÓPEZ-CARA; Giulia Saponaro; Mojgan Aghazadeh Tabrizi; Katia Varani; Abdel Naser Zaid; Pier Andrea Borea
New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2011;54(14):5205-20.
2011: Ombretta Lenzi; Lucia Squarcialupi; Katia Varani; Flavia Varano; Fabrizio Vincenzi; Diego Dal Ben; Pier Andrea Borea; Daniela Catarzi; Vittoria Colotta; Guido Filacchioni; Catia Lambertucci; Gloria Cristalli
Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2011;19(12):3757-68.
2011: Katia Varani; Stefania Maniero; Fabrizio Vincenzi; Martina Targa; Angela Stefanelli; Pio Maniscalco; Fernanda Martini; Mauro Tognon; Pier Andrea Borea
A₃ receptors are overexpressed in pleura from patients with mesothelioma and reduce cell growth via Akt/nuclear factor-κB pathway.
American journal of respiratory and critical care medicine 2011;183(4):522-30.
2011: Katia Varani; Fabrizio Vincenzi; Marcello Govoni; Melissa Padovan; Martina Targa; Francesco Trotta; Pier Andrea Borea
A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release.
Arthritis research & therapy 2011;13(6):R197.
2010: Katia Varani; Melissa Padovan; Marcello Govoni; Fabrizio Vincenzi; Francesco Trotta; Pier Andrea Borea
The role of adenosine receptors in rheumatoid arthritis.
Autoimmunity reviews 2010;10(2):61-4.
2010: Stefania Gessi; Valeria Sacchetto; Eleonora Fogli; Stefania Merighi; Katia Varani; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Edward Leung; Stephen Maclennan; Pier Andrea Borea
Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors.
Biochemical pharmacology 2010;79(10):1483-95.
2010: Katia Varani; Gaetano Caramori; Fabrizio Vincenzi; Alice Tosi; Adam Barczyk; Marco Contoli; Paolo Casolari; Massimo Triggiani; Trevor Hansel; Edward Leung; Stephen Maclennan; Peter J Barnes; Kian Fan Chung; Ian Adcock; Alberto Papi; Pier Andrea Borea
Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(4):1192-204.
2010: Katia Varani; Fabrizio Vincenzi; Alice Tosi; Stefania Gessi; Ilaria Casetta; Gino Granieri; Patrik Fazio; Edward Leung; Stephen Maclennan; Enrico Granieri; Pier Andrea Borea
A2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(2):587-98.
2010: Stefania Merighi; Carolina Simioni; Stefania Gessi; Katia Varani; Pier Andrea Borea
Binding thermodynamics at the human cannabinoid CB1 and CB2 receptors.
Biochemical pharmacology 2010;79(3):471-7.
2010: Cristiano Nazzaro; Mario Barbieri; Katia Varani; Lorenzo Beani; Rita J Valentino; Anna Siniscalchi
Swim stress enhances nociceptin/orphanin FQ-induced inhibition of rat dorsal raphe nucleus activity in vivo and in vitro: role of corticotropin releasing factor.
Neuropharmacology 2010;58(2):457-64.
2010: Katia Varani; Monica De Mattei; Fabrizio Vincenzi; Azzurra Tosi; Martina Targa; Federica F Masieri; Agnese Pellati; Leo Massari; Pier Andrea Borea
P2X(1) and P2X(3) purinergic receptors differentially modulate the inflammatory response in human osteoarthritic synovial fibroblasts.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;25(2-3):325-36.
2010: Stefania Gessi; Eleonora Fogli; Valeria Sacchetto; Stefania Merighi; Katia Varani; Delia Preti; Edward Leung; Stephen Maclennan; Pier Andrea Borea
Adenosine modulates HIF-1{alpha}, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(1):90-7.
2009: Ombretta Lenzi; Vittoria Colotta; Daniela Catarzi; Flavia Varano; Daniela Poli; Guido Filacchioni; Katia Varani; Fabrizio Vincenzi; Pier Andrea Borea; Silvia Paoletta; Erika Morizzo; Stefano Moro
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.
Journal of medicinal chemistry 2009;52(23):7640-52.
2009: Stefania Merighi; Carolina Simioni; Stefania Gessi; Katia Varani; Prisco Mirandola; Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Pier Andrea Borea
A(2B) and A(3) adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and doxorubicin.
Neoplasia (New York, N.Y.) 2009;11(10):1064-73.
2009: Katia Varani; Alfonso Massara; Fabrizio Vincenzi; Alice Tosi; Melissa Padovan; Francesco Trotta; Pier Andrea Borea
Normalization of A2A and A3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate.
Arthritis and rheumatism 2009;60(10):2880-91.
2009: Pamela Crepaldi; Barbara Cacciari; Maria-Cruz Bonache; Giampiero Spalluto; Katia Varani; Pier Andrea Borea; Ivar von Kügelgen; Kristina Hoffmann; Mariateresa Pugliano; Cristina Razzari; Marco Cattaneo
6-Amino-2-mercapto-3H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y12 receptors.
Bioorganic & medicinal chemistry 2009;17(13):4612-21.
2009: Gianluca Aguiari; Katia Varani; Marco Bogo; Alessandra Mangolini; Fabrizio Vincenzi; Chiara Durante; Stefania Gessi; Valeria Sacchetto; Luigi Catizone; Peter Harris; Rosario Rizzuto; Pier Andrea Borea; Laura del Senno
Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A(3) adenosine receptors in human renal cells: implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells.
Biochimica et biophysica acta 2009;1792(6):531-40.
2009: Olga Bruno; Chiara Brullo; Francesco Bondavalli; Silvia Schenone; Susanna Spisani; Maria Sofia Falzarano; Katia Varani; Elisabetta Barocelli; Vigilio Ballabeni; Carmine Giorgio; Massimiliano Tognolini
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors.
Bioorganic & medicinal chemistry 2009;17(9):3379-87.
2009: Monica De Mattei; Katia Varani; F F Masieri; Agnese Pellati; Alessia Ongaro; Milena Fini; Ruggero Cadossi; Fabrizio Vincenzi; Pier Andrea Borea; Angelo Caruso
Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(2):252-62.
2008: Pier Giovanni Baraldi; Delia Preti; Mojgan Aghazadeh Tabrizi; LUISA-CARLOTA LÓPEZ-CARA; Giulia Saponaro; Stefania Baraldi; Maurizio Botta; Cesare Bernardini; Andrea Tafi; Tiziano Tuccinardi; Adriano Martinelli; Katia Varani; Pier Andrea Borea
Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2008;16(24):10281-94.
2008: Katia Varani; Monica De Mattei; Fabrizio Vincenzi; Azzurra Tosi; Stefania Gessi; Stefania Merighi; Agnese Pellati; F Masieri; Alessia Ongaro; Pier Andrea Borea
Pharmacological characterization of P2X1 and P2X3 purinergic receptors in bovine chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(11):1421-9.
2008: Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Olga Cruz-Lopez; Maria Antonietta Iaconinoto; Delia Preti; John C Shryock; Allan R Moorman; Fabrizio Vincenzi; Katia Varani; Pier Andrea Borea
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.
Journal of medicinal chemistry 2008;51(18):5875-9.
2008: Maura Floreani; Katia Varani; Luigi Quintieri; Pier Andrea Borea; Paola Dorigo
Comparison of the binding affinity of CGP-12177A at recombinant rat alpha(1D)-adrenoceptors expressed in BHK-21 cell membranes and alpha(1)-adrenoceptors present in rat cerebral cortex membranes.
European journal of pharmacology 2008;590(1-3):303-9.
2008: Maura Floreani; Luigi Quintieri; Katia Varani; Maria Teresa Dorigo; Paola Dorigo
Carteolol, a non-conventional partial agonist of beta(1)-adrenoceptors, relaxes phenylephrine-constricted rat aorta through antagonism at alpha(1)-adrenoceptors.
European journal of pharmacology 2008;590(1-3):269-75.
2008: Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Delia Preti; LUISA-CARLOTA LÓPEZ-CARA; Giulia Saponaro; Stefania Baraldi; Allan R Moorman; Abdel Naser Zaid; Katia Varani; Pier Andrea Borea
1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2008;16(5):2419-30.
2008: Katia Varani; Annmarie Surprenant; Fabrizio Vincenzi; Alice Tosi; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Binding thermodynamic characterization of human P2X1 and P2X3 purinergic receptors.
Biochemical pharmacology 2008;75(5):1198-208.
2008: Katia Varani; Monica De Mattei; Fabrizio Vincenzi; Stefania Gessi; Stefania Merighi; Agnese Pellati; Alessia Ongaro; Angelo Caruso; Ruggero Cadossi; Pier Andrea Borea
Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromagnetic fields.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(3):292-304.
2008: Stefania Gessi; Eleonora Fogli; Valeria Sacchetto; Katia Varani; Stefania Merighi; Edward Leung; Stephen Mac Lennan; Pier Andrea Borea
Thermodynamics of A2B adenosine receptor binding discriminates agonistic from antagonistic behaviour.
Biochemical pharmacology 2008;75(2):562-9.
2008: Stefania Gessi; Stefania Merighi; Katia Varani; Edward Leung; Stephen Mac Lennan; Pier Andrea Borea
The A3 adenosine receptor: an enigmatic player in cell biology.
Pharmacology & therapeutics 2008;117(1):123-40.
2007: Erika Morizzo; Francesca Capelli; Ombretta Lenzi; Daniela Catarzi; Flavia Varano; Guido Filacchioni; Fabrizio Vincenzi; Katia Varani; Pier Andrea Borea; Vittoria Colotta; Stefano Moro
Scouting human A3 adenosine receptor antagonist binding mode using a molecular simplification approach: from triazoloquinoxaline to a pyrimidine skeleton as a key study.
Journal of medicinal chemistry 2007;50(26):6596-606.
2007: Luca Guandalini; Monica Norcini; Katia Varani; Marco Pistolozzi; Cecilia Gotti; Carla Bazzicalupi; Elisabetta Martini; Silvia Dei; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Carlo Bertucci; Carla Ghelardini; Maria Novella Romanelli
Design, synthesis, and preliminary pharmacological evaluation of new quinoline derivatives as nicotinic ligands.
Journal of medicinal chemistry 2007;50(20):4993-5002.
2007: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Carolina Simioni; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.
Molecular pharmacology 2007;72(2):395-406.
2007: Susanna Spisani; Anna Fraulini; Katia Varani; Sofia Falzarano; Giorgio Cavicchioni
New chemotactic dimeric peptides show high affinity and potency at the human formylpeptide receptor.
European journal of pharmacology 2007;567(1-2):171-6.
2007: Katia Varani; Anne-Catherine Bachoud-Lévi; Caterina Mariotti; Alessia Tarditi; Maria P Abbracchio; V Gasperi; Pier Andrea Borea; Guillaume Dolbeau; Cinzia Gellera; A Solari; A Rosser; J Naji; O Handley; Mauro Maccarrone; Marc Peschanski; Stefano DiDonato; Elena Cattaneo
Biological abnormalities of peripheral A(2A) receptors in a large representation of polyglutamine disorders and Huntington's disease stages.
Neurobiology of disease 2007;27(1):36-43.
2007: Olga Bruno; Chiara Brullo; Francesco Bondavalli; Angelo Ranise; Silvia Schenone; Maria Sofia Falzarano; Katia Varani; Susanna Spisani
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: new potent inhibitors of fMLP-induced neutrophil chemotaxis.
Bioorganic & medicinal chemistry letters 2007;17(13):3696-701.
2007: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells.
Molecular pharmacology 2007;72(1):162-72.
2007: Stefania Gessi; Stefania Merighi; Katia Varani; Elena Cattabriga; Annalisa Benini; Prisco Mirandola; Edward Leung; Stephen Mac Lennan; Claudio F Feo; Stefania Baraldi; Pier Andrea Borea
Adenosine receptors in colon carcinoma tissues and colon tumoral cell lines: focus on the A(3) adenosine subtype.
Journal of cellular physiology 2007;211(3):826-36.
2007: Pier Giovanni Baraldi; Delia Preti; Mojgan Aghazadeh Tabrizi; Francesca Fruttarolo; Giulia Saponaro; Stefania Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Allan R Moorman; Stefania Gessi; Katia Varani; Pier Andrea Borea
N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor.
Bioorganic & medicinal chemistry 2007;15(7):2514-27.
2007: Stefania Gessi; Katia Varani; Stefania Merighi; Eleonora Fogli; Valeria Sacchetto; Annalisa Benini; Edward Leung; Stephen Mac Lennan; Pier Andrea Borea
Adenosine and lymphocyte regulation.
Purinergic signalling 2007;3(1-2):109-16.
2007: Pier Giovanni Baraldi; Delia Preti; Mojgan Aghazadeh Tabrizi; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Maria Dora Carrion; Luisa Carlota Lopez Cara; Allan R Moorman; Katia Varani; Pier Andrea Borea
Synthesis and biological evaluation of novel 1-deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide derivatives as useful templates for the development of A2B adenosine receptor agonists.
Journal of medicinal chemistry 2007;50(2):374-80.
2006: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A₃ adenosine receptor.
Purinergic signalling 2006;2(4):627-32.
2006: Stefania Gessi; Katia Varani; Stefania Merighi; Edward Leung; Stephen Mac Lennan; Pier Giovanni Baraldi; Pier Andrea Borea
Novel selective antagonist radioligands for the pharmacological study of A(2B) adenosine receptors.
Purinergic signalling 2006;2(4):583-8.
2006: Romeo Romagnoli; Pier Giovanni Baraldi; Allan R Moorman; Maria Antonietta Iaconinoto; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Mojgan Aghazadeh Tabrizi; Delia Preti; Francesca Fruttarolo; Stephen P Baker; Katia Varani; Pier Andrea Borea
Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A(1) receptor.
Bioorganic & medicinal chemistry letters 2006;16(21):5530-3.
2006: M Antonietta Stasi; Franco Borsini; Katia Varani; Fabrizio Vincenzi; M Assunta Di Cesare; Patrizia Minetti; Orlando Ghirardi; Paolo Carminati
ST 1535: a preferential A2A adenosine receptor antagonist.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2006;9(5):575-84.
2006: Alessia Tarditi; Alessandra Camurri; Katia Varani; Pier Andrea Borea; Ben Woodman; Gillian P Bates; Elena Cattaneo; Maria P Abbracchio
Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease.
Neurobiology of disease 2006;23(1):44-53.
2006: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Andrea Borea
Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells.
Biochemical pharmacology 2006;72(1):19-31.
2006: Giorgia Pastorin; Tatiana Da Ros; Chiara Bolcato; Christian Montopoli; Stefano Moro; Barbara Cacciari; Pier Giovanni Baraldi; Katia Varani; Pier Andrea Borea; Giampiero Spalluto
Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations.
Journal of medicinal chemistry 2006;49(5):1720-9.
2006: Pier Giovanni Baraldi; Maria Giovanna Pavani; Edward Leung; Allan R Moorman; Katia Varani; Fabrizio Vincenzi; Pier Andrea Borea; LUISA-CARLOTA LÓPEZ-CARA
Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer.
Bioorganic & medicinal chemistry letters 2006;16(5):1402-4.
2006: Katia Varani; Gaetano Caramori; Fabrizio Vincenzi; Ian Adcock; Paolo Casolari; Edward Leung; Stephen Maclennan; Stefania Gessi; Silvana Morello; Peter J Barnes; Kazuhiro Ito; K Fan Chung; Giorgio Cavallesco; Gianfranco Azzena; Alberto Papi; Pier Andrea Borea
Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2006;173(4):398-406.
2005: Maura Floreani; Guglielmina Froldi; Luigi Quintieri; Katia Varani; Pier Andrea Borea; Maria Teresa Dorigo; Paola Dorigo
In vitro evidence that carteolol is a nonconventional partial agonist of guinea pig cardiac beta1-adrenoceptors: a comparison with xamoterol.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1386-95.
2005: Katia Varani; Stefania Gessi; Stefania Merighi; Fabrizio Vincenzi; Elena Cattabriga; Annalisa Benini; Karl-Norbert Klotz; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Stephen Mac Lennan; Edward Leung; Pier Andrea Borea
Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors.
Biochemical pharmacology 2005;70(11):1601-12.
2005: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
A3 adenosine receptors modulate hypoxia-inducible factor-1alpha expression in human A375 melanoma cells.
Neoplasia (New York, N.Y.) 2005;7(10):894-903.
2005: Katia Varani; Francesco Portaluppi; Stefania Gessi; Stefania Merighi; Fabrizio Vincenzi; Elena Cattabriga; Alessandro Dalpiaz; F Bortolotti; L Belardinelli; Pier Andrea Borea
Caffeine intake induces an alteration in human neutrophil A2A adenosine receptors.
Cellular and molecular life sciences : CMLS 2005;62(19-20):2350-8.
2005: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Delia Preti; Andrea Bovero; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Naser Abdel Zaid; Allan R Moorman; Katia Varani; Pier Andrea Borea
New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2005;48(15):5001-8.
2005: Pier Giovanni Baraldi; Delia Preti; Mojgan Aghazadeh Tabrizi; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Naser Abdel Zaid; Allan R Moorman; Stefania Merighi; Katia Varani; Pier Andrea Borea
New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2005;48(14):4697-701.
2005: Stefania Gessi; Katia Varani; Stefania Merighi; Elena Cattabriga; Cecilia Pancaldi; Youri Szabadkai; Rosario Rizzuto; Karl-Norbert Klotz; Edward Leung; Stephen Mac Lennan; Pier Giovanni Baraldi; Pier Andrea Borea
Expression, pharmacological profile, and functional coupling of A2B receptors in a recombinant system and in peripheral blood cells using a novel selective antagonist radioligand, [3H]MRE 2029-F20.
Molecular pharmacology 2005;67(6):2137-47.
2005: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Andrea Borea
A3 adenosine receptor activation inhibits cell proliferation via phosphatidylinositol 3-kinase/Akt-dependent inhibition of the extracellular signal-regulated kinase 1/2 phosphorylation in A375 human melanoma cells.
The Journal of biological chemistry 2005;280(20):19516-26.
2005: Daniele Simoni; Marcello Rossi; Valerio Bertolasi; Marinella Roberti; Daniela Pizzirani; Riccardo Rondanin; Riccardo Baruchello; Francesco Paolo Invidiata; Manlio Tolomeo; Stefania Grimaudo; Stefania Merighi; Katia Varani; Stefania Gessi; Pier Andrea Borea; Silvia Marino; Sabrina Cavallini; Clementina Bianchi; Anna Siniscalchi
Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter.
Journal of medicinal chemistry 2005;48(9):3337-43.
2005: Giorgio Cavicchioni; Anna Fraulini; Marianna Turchetti; Katia Varani; Sofia Falzarano; Barbara Pavan; Susanna Spisani
Biological activity of for-Met-Leu-Phe-OMe analogs: relevant substitutions specifically trigger killing mechanisms in human neutrophils.
European journal of pharmacology 2005;512(1):1-8.
2005: Paola Gilli; Gastone Gilli; Pier Andrea Borea; Katia Varani; Angelo Scatturin; Alessandro Dalpiaz
Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors.
Journal of medicinal chemistry 2005;48(6):2026-35.
2005: Angela Rampa; Alessandra Bisi; Federica Belluti; Silvia Gobbi; Lorna Piazzi; Piero Valenti; Antonella Zampiron; Anna Caputo; Katia Varani; Pier Andrea Borea; Maria Carrara
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells.
Farmaco (Società chimica italiana : 1989) 2005;60(2):135-47.
2005: Luca Guandalini; Elisabetta Martini; Cecilia Martelli; Maria Novella Romanelli; Katia Varani
Rigid analogs of DMPP as probes for the nicotinic receptors.
Farmaco (Società chimica italiana : 1989) 2005;60(2):99-104.
2005: Luca Guandalini; Elisabetta Martini; Silvia Dei; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Maria Novella Romanelli; Katia Varani; Giovanni Greco; Loredana Spadola; Ettore Novellino
Design of novel nicotinic ligands through 3D database searching.
Bioorganic & medicinal chemistry 2005;13(3):799-807.
2005: Stefano Moro; Paolo Braiuca; Francesca Deflorian; Cristina Ferrari; Giorgia Pastorin; Barbara Cacciari; Pier Giovanni Baraldi; Katia Varani; Pier Andrea Borea; Giampiero Spalluto
Combined target-based and ligand-based drug design approach as a tool to define a novel 3D-pharmacophore model of human A3 adenosine receptor antagonists: pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as a key study.
Journal of medicinal chemistry 2005;48(1):152-62.
2005: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; LUISA-CARLOTA LÓPEZ-CARA; Francesca Fruttarolo; Stefania Merighi; Katia Varani; Stefania Gessi; Pier Andrea Borea
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine ligands, new tools to characterize A3 adenosine receptors in human tumor cell lines.
Current medicinal chemistry 2005;12(11):1319-29.
2004: Pier Giovanni Baraldi; Francesca Fruttarolo; Mojgan Aghazadeh Tabrizi; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti; Andrea Bovero; Maria Josè Pineda de las Infantas; Allan Moorman; Katia Varani; Pier Andrea Borea
Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.
Journal of medicinal chemistry 2004;47(22):5535-40.
2004: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Delia Preti; Andrea Bovero; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Allan R Moorman; Stefania Gessi; Stefania Merighi; Katia Varani; Pier Andrea Borea
[3H]-MRE 2029-F20, a selective antagonist radioligand for the human A2B adenosine receptors.
Bioorganic & medicinal chemistry letters 2004;14(13):3607-10.
2004: Maura Floreani; Guglielmina Froldi; Maurizio Cavalli; Sergio Bova; Maria Cecilia Giron; Katia Varani; Stefania Gessi; Pier Andrea Borea; Maria Teresa Dorigo; Paola Dorigo
Characterization of intrinsic sympathomimetic activity of carteolol in rat cardiovascular preparations.
Journal of pharmacological sciences 2004;95(1):115-23.
2004: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Delia Preti; Andrea Bovero; LUISA-CARLOTA LÓPEZ-CARA; Francesca Fruttarolo; Naser Abdel Zaid; Allan R Moorman; Katia Varani; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.
Journal of medicinal chemistry 2004;47(6):1434-47.
2004: Stefania Gessi; Katia Varani; Stefania Merighi; Elena Cattabriga; Arianna Avitabile; Riccardo Gavioli; Cinzia Fortini; Edward Leung; Stephen Mac Lennan; Pier Andrea Borea
Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation.
Molecular pharmacology 2004;65(3):711-9.
2004: Pier Andrea Borea; Katia Varani; Stefania Gessi; Stefania Merighi; Alessandro Dal Piaz; Paola Gilli; Gastone Gilli
Receptor binding thermodynamics at the neuronal nicotinic receptor.
Current topics in medicinal chemistry 2004;4(3):361-8.
2003: Katia Varani; Stefania Gessi; Stefania Merighi; Valeria Iannotta; Elena Cattabriga; Cecilia Pancaldi; Ruggero Cadossi; Pier Andrea Borea
Alteration of A(3) adenosine receptors in human neutrophils and low frequency electromagnetic fields.
Biochemical pharmacology 2003;66(10):1897-906.
2003: Alessandra Boschi; Licia Uccelli; Adriano Duatti; Cristina Bolzati; Fiorenzo Refosco; Francesco Tisato; LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Katia Varani; Pier Andrea Borea
Asymmetrical nitrido tc-99m heterocomplexes as potential imaging agents for benzodiazepine receptors.
Bioconjugate chemistry 2003;14(6):1279-88.
2003: Katia Varani; Maria P Abbracchio; Milena Cannella; giuliana cislaghi; Patrizia Giallonardo; Caterina Mariotti; Elena Cattabriga; Flaminio Nicola Cattabeni; Pier Andrea Borea; Ferdinando Squitieri; Elena Cattaneo
Aberrant A2A receptor function in peripheral blood cells in Huntington's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2148-50.
2003: Stefania Merighi; Prisco Mirandola; Katia Varani; Stefania Gessi; Edward Leung; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Pier Andrea Borea
A glance at adenosine receptors: novel target for antitumor therapy.
Pharmacology & therapeutics 2003;100(1):31-48.
2003: Giorgia Pastorin; Tatiana Da Ros; Giampiero Spalluto; Francesca Deflorian; Stefano Moro; Barbara Cacciari; Pier Giovanni Baraldi; Stefania Gessi; Katia Varani; Pier Andrea Borea
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.
Journal of medicinal chemistry 2003;46(20):4287-96.
2003: Pier Giovanni Baraldi; Andrea Bovero; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Mojgan Aghazadeh Tabrizi; Delia Preti; Katia Varani; Pier Andrea Borea; Allan R Moorman
New strategies for the synthesis of A3 adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2003;11(19):4161-9.
2003: Stefania Merighi; Prisco Mirandola; Katia Varani; Stefania Gessi; Silvano Capitani; Edward Leung; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Pier Andrea Borea
Pyrazolotriazolopyrimidine derivatives sensitize melanoma cells to the chemotherapic drugs: taxol and vindesine.
Biochemical pharmacology 2003;66(5):739-48.
2003: Giorgio Cavicchioni; Marianna Turchetti; Katia Varani; Sofia Falzarano; Susanna Spisani
Properties of a novel chemotactic esapeptide, an analogue of the prototypical N-formylmethionyl peptide.
Bioorganic chemistry 2003;31(4):322-30.
2003: Susanna Spisani; Marianna Turchetti; Katia Varani; Sofia Falzarano; Giorgio Cavicchioni
Hydrophilic residues at position 3 highlight unforeseen features of the fMLP receptor pocket.
European journal of pharmacology 2003;469(1-3):13-9.
2003: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Andrea Bovero; Barbara Avitabile; Delia Preti; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Katia Varani; Pier Andrea Borea
Recent developments in the field of A2A and A3 adenosine receptor antagonists.
European journal of medicinal chemistry 2003;38(4):367-82.
2003: Pier Giovanni Baraldi; Francesca Fruttarolo; Mojgan Aghazadeh Tabrizi; Delia Preti; LUISA-CARLOTA LÓPEZ-CARA; Hussein El-Kashef; Allan Moorman; Katia Varani; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.
Journal of medicinal chemistry 2003;46(7):1229-41.
2003: Katia Varani; Franco Laghi Pasini; Alessandra Camurri; Pier Leopoldo Capecchi; Massimo Maccherini; Francesco Diciolla; Linda Ceccatelli; Pietro Enea Lazzerini; Canan Ulouglu; Flaminio Nicola Cattabeni; Pier Andrea Borea; Maria P Abbracchio
Changes of peripheral A2A adenosine receptors in chronic heart failure and cardiac transplantation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):280-2.
2003: Alessandro Dalpiaz; Gianni Vertuani; Angelo Scatturin; Federica Vitali; Katia Varani; Susanna Spisani
Conformational aspects of human formyl-peptide receptor agonists.
Arzneimittel-Forschung 2003;53(11):793-8.
2002: Katia Varani; Roberto Manfredini; Valeria Iannotta; Cecilia Pancaldi; Elena Cattabriga; Canan Uluoglu; Pier Andrea Borea; Francesco Portaluppi
Effects of doxazosin and propranolol on A2A adenosine receptors in essential hypertension.
Hypertension 2002;40(6):909-13.
2002: Stefania Merighi; Prisco Mirandola; Daniela Milani; Katia Varani; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Pier Andrea Borea
Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells.
The Journal of investigative dermatology 2002;119(4):923-33.
2002: Anna Maconi; Giorgia Pastorin; Tatiana Da Ros; Giampiero Spalluto; Zhan-Guo Gao; Kenneth Alan Jacobson; Pier Giovanni Baraldi; Barbara Cacciari; Katia Varani; Stefano Moro; Pier Andrea Borea
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.
Journal of medicinal chemistry 2002;45(17):3579-82.
2002: Luca Guandalini; Silvia Dei; Dina Manetti; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori; Katia Varani
Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands.
Farmaco (Società chimica italiana : 1989) 2002;57(6):487-96.
2002: Katia Varani; Stefania Gessi; Stefania Merighi; Valeria Iannotta; Elena Cattabriga; Susanna Spisani; Ruggero Cadossi; Pier Andrea Borea
Effect of low frequency electromagnetic fields on A2A adenosine receptors in human neutrophils.
British journal of pharmacology 2002;136(1):57-66.
2002: Pier Giovanni Baraldi; Barbara Cacciari; Stefano Moro; Giampiero Spalluto; Giorgia Pastorin; Tatiana Da Ros; Karl-Norbert Klotz; Katia Varani; Stefania Gessi; Pier Andrea Borea
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(4):770-80.
2002: Stefania Gessi; Katia Varani; Stefania Merighi; Elena Cattabriga; Valeria Iannotta; Edward Leung; Pier Giovanni Baraldi; Pier Andrea Borea
A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.
Molecular pharmacology 2002;61(2):415-24.
2002: Stefania Merighi; Katia Varani; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Pier Andrea Borea
Binding thermodynamics at the human A(3) adenosine receptor.
Biochemical pharmacology 2002;63(2):157-61.
2002: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Angela Monopoli; Ennio Ongini; Katia Varani; Pier Andrea Borea
7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility.
Journal of medicinal chemistry 2002;45(1):115-26.
2001: Remo Guerrini; Girolamo Caló; Raffaella Bigoni; Daniela Rizzi; Anna Rizzi; M Zucchini; Katia Varani; Eiji Hashiba; David G Lambert; Géza Toth; Pier Andrea Borea; Severo Salvadori; Domenico Regoli
Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor.
Journal of medicinal chemistry 2001;44(23):3956-64.
2001: Maria Novella Romanelli; Dina Manetti; Serena Scapecchi; Pier Andrea Borea; Silvia Dei; Alessandro Bartolini; Carla Ghelardini; Fulvio Gualtieri; Luca Guandalini; Katia Varani
Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP).
Journal of medicinal chemistry 2001;44(23):3946-55.
2001: Stefania Merighi; Katia Varani; Stefania Gessi; Elena Cattabriga; Valeria Iannotta; C Ulouglu; Edward Leung; Pier Andrea Borea
Pharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell line.
British journal of pharmacology 2001;134(6):1215-26.
2001: Stefania Gessi; Katia Varani; Stefania Merighi; Antonio Morelli; Davide Ferrari; Edward Leung; Pier Giovanni Baraldi; Giampiero Spalluto; Pier Andrea Borea
Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells.
British journal of pharmacology 2001;134(1):116-26.
2001: Katia Varani; Dorotea Rigamonti; Simonetta Sipione; Alessandra Camurri; Pier Andrea Borea; Flaminio Nicola Cattabeni; Maria P Abbracchio; Elena Cattaneo
Aberrant amplification of A(2A) receptor signaling in striatal cells expressing mutant huntingtin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(7):1245-7.
2001: Daniele Simoni; Marinella Roberti; Riccardo Rondanin; Riccardo Baruchello; Marcello Rossi; Francesco Paolo Invidiata; Stefania Merighi; Katia Varani; Stefania Gessi; Pier Andrea Borea; Silvia Marino; Sabrina Cavallini; Clementina Bianchi; Anna Siniscalchi
Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter.
Bioorganic & medicinal chemistry letters 2001;11(6):823-7.
2001: Alessandro Dalpiaz; Angelo Scatturin; Gianni Vertuani; R Pecoraro; P A Borea; Katia Varani; Serena Traniello; Susanna Spisani
Met-Ile-Phe-Leu derivatives: full and partial agonists of human neutrophil formylpeptide receptors.
European journal of pharmacology 2001;411(3):327-33.
2000: Pier Andrea Borea; Alessandro Dalpiaz; Katia Varani; Paola Gilli; Gastone Gilli
Can thermodynamic measurements of receptor binding yield information on drug affinity and efficacy?
Biochemical pharmacology 2000;60(11):1549-56.
2000: Sergio Todde; Rosa Maria Moresco; Pasquale Simonelli; P G Baraldi; Barbara Cacciari; Giampiero Spalluto; Katia Varani; Angela Monopoli; Mario Matarrese; Assunta Carpinelli; Fulvio Magni; Marzia Galli Kienle; Ferruccio Fazio
Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography.
Journal of medicinal chemistry 2000;43(23):4359-62.
2000: Laura Quartara; R Ricci; stefania meini; Riccardo Patacchini; Alessandro Giolitti; Silvia Amadesi; C Rizzi; Anna Rizzi; Katia Varani; P A Borea; Carlo Alberto Maggi; Domenico Regoli
Ala scan analogues of HOE 140. Synthesis and biological activities.
European journal of medicinal chemistry 2000;35(11):1001-10.
2000: Alessandro Dalpiaz; Angelo Scatturin; Katia Varani; R Pecoraro; Barbara Pavan; P A Borea
Binding thermodynamics and intrinsic activity of adenosine A1 receptor ligands.
Life sciences 2000;67(12):1517-24.
2000: Remo Guerrini; Girolamo Caló; Raffaella Bigoni; Anna Rizzi; Katia Varani; Géza Toth; Stefania Gessi; Eiji Hashiba; Y Hashimoto; David G Lambert; Pier Andrea Borea; Roberto Tomatis; Severo Salvadori; Domenico Regoli
Further studies on nociceptin-related peptides: discovery of a new chemical template with antagonist activity on the nociceptin receptor.
Journal of medicinal chemistry 2000;43(15):2805-13.
2000: Katia Varani; Francesco Portaluppi; Stefania Gessi; Stefania Merighi; Ennio Ongini; L Belardinelli; Pier Andrea Borea
Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors : functional and biochemical aspects.
Circulation 2000;102(3):285-9.
2000: Katia Varani; Stefania Merighi; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Pier Andrea Borea
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.
Molecular pharmacology 2000;57(5):968-75.
2000: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Stefania Merighi; Katia Varani; Pier Andrea Borea; Giampiero Spalluto
A(3) adenosine receptor ligands: history and perspectives.
Medicinal research reviews 2000;20(2):103-28.
2000: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Katia Varani; Stefania Merighi; Stefania Gessi; Pier Andrea Borea; Edward Leung; S L Hickey; Giampiero Spalluto
Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors.
Bioorganic & medicinal chemistry letters 2000;10(3):209-11.
2000: Francesco Portaluppi; Roberto Manfredini; Katia Varani; Stefania Gessi; A Caiazza; Pier Andrea Borea
Platelet alpha2-adrenoceptor alterations in patients with essential hypertension are normalized after treatment with doxazosin but not propranolol.
Journal of hypertension 2000;18(2):217-21.
2000: Stefania Gessi; Katia Varani; Stefania Merighi; Ennio Ongini; Pier Andrea Borea
A(2A) adenosine receptors in human peripheral blood cells.
British journal of pharmacology 2000;129(1):2-11.
1999: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Karl-Norbert Klotz; E Leung; Katia Varani; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 1999;42(22):4473-8.
1999: Anna Rizzi; C Rizzi; Silvia Amadesi; Girolamo Calo'; Katia Varani; N Inamura; Domenico Regoli
Pharmacological characterisation of the first non-peptide bradykinin B2 receptor agonist FR 190997: an in vitro study on human, rabbit and pig vascular B2 receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1999;360(4):361-7.
1999: Giorgio Cavicchioni; Katia Varani; S Niccoli; O Rizzuti; Susanna Spisani
An evaluation of fMLP pocket dimensions and features using formyltetrapeptides.
The journal of peptide research : official journal of the American Peptide Society 1999;54(4):336-43.
1999: Katia Varani; Anna Rizzi; Girolamo Calo; Raffaella Bigoni; Géza Toth; Remo Guerrini; Stefania Gessi; Severo Salvadori; Pier Andrea Borea; Domenico Regoli
Pharmacology of [Tyr1]nociceptin analogs: receptor binding and bioassay studies.
Naunyn-Schmiedeberg's archives of pharmacology 1999;360(3):270-7.
1999: Alessandro Dalpiaz; Angelo Scatturin; Barbara Pavan; Katia Varani; A P IJzerman; P Andrea Borea
Thermodynamic in vitro studies as a method to investigate the pharmacodynamic behavior of adenosine A1 receptor ligands.
Pharmaceutical research 1999;16(7):1054-8.
1999: Katia Varani; Francesco Portaluppi; Stefania Merighi; Ennio Ongini; L Belardinelli; Pier Andrea Borea
Caffeine alters A2A adenosine receptors and their function in human platelets.
Circulation 1999;99(19):2499-502.
1999: Dina Manetti; Alessandro Bartolini; Pier Andrea Borea; Cristina Bellucci; Silvia Dei; Carla Ghelardini; Fulvio Gualtieri; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori; Katia Varani
Hybridized and isosteric analogues of N1-acetyl-N4-dimethyl-piperazinium iodide (ADMP) and N1-phenyl-N4-dimethyl-piperazinium iodide (DMPP) with central nicotinic action.
Bioorganic & medicinal chemistry 1999;7(3):457-65.
1999: Katia Varani; Stefania Gessi; A Caiazza; G Rastelli; Francesco Portaluppi; Pier Andrea Borea
Platelet alpha2-adrenoceptor alterations in patients with essential hypertension.
British journal of clinical pharmacology 1999;47(2):167-72.
1999: Gianni Bregola; Katia Varani; Stefania Gessi; Lorenzo Beani; Clementina Bianchi; Pier Andrea Borea; Domenico Regoli; Michele Simonato
Changes in hippocampal and cortical B1 bradykinin receptor biological activity in two experimental models of epilepsy.
Neuroscience 1999;92(3):1043-9.
1999: Stefania Gessi; Alessandro Dalpiaz; Katia Varani; Pier Andrea Borea
Temperature dependence and GABA modulation of beta-carboline binding to rat cerebellum benzodiazepine receptors.
Life sciences 1999;64(16):PL185-92.
1999: Stefania Gessi; F Campi; Katia Varani; Pier Andrea Borea
Alpha2-adrenergic agonist modulation of [35S]GTPgammaS binding to guanine-nucleotide-binding-proteins in human platelet membranes.
Life sciences 1999;64(16):1403-13.
1998: Katia Varani; Girolamo Calo; Anna Rizzi; Stefania Merighi; Géza Toth; Remo Guerrini; Severo Salvadori; Pier Andrea Borea; Domenico Regoli
Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships.
British journal of pharmacology 1998;125(7):1485-90.
1998: Pier Giovanni Baraldi; Barbara Cacciari; Giampiero Spalluto; M Bergonzoni; S Dionisotti; Ennio Ongini; Katia Varani; Pier Andrea Borea
Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.
Journal of medicinal chemistry 1998;41(12):2126-33.
1998: Pier Andrea Borea; Katia Varani; Stefania Gessi; Paola Gilli; Gastone Gilli
Binding thermodynamics at the human neuronal nicotine receptor.
Biochemical pharmacology 1998;55(8):1189-97.
1998: Pier Andrea Borea; Katia Varani; Stefania Gessi; Paola Gilli; Alessandro Dalpiaz
Receptor binding thermodynamics as a tool for linking drug efficacy and affinity.
Farmaco (Società chimica italiana : 1989) 1998;53(4):249-54.
1998: Katia Varani; Stefania Gessi; S Dionisotti; Ennio Ongini; Pier Andrea Borea
[3H]-SCH 58261 labelling of functional A2A adenosine receptors in human neutrophil membranes.
British journal of pharmacology 1998;123(8):1723-31.
1998: Katia Varani; Barbara Cacciari; Pier Giovanni Baraldi; S Dionisotti; Ennio Ongini; Pier Andrea Borea
Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors.
Life sciences 1998;63(5):PL 81-7.
1997: Katia Varani; Stefania Gessi; Alessandro Dalpiaz; Ennio Ongini; Pier Andrea Borea
Characterization of A2A adenosine receptors in human lymphocyte membranes by [3H]-SCH 58261 binding.
British journal of pharmacology 1997;122(2):386-92.
1997: Guglielmina Froldi; Katia Varani; A Chinellato; Eugenio Ragazzi; Laura Caparrotta; Pier Andrea Borea
P2X-purinoceptors in the heart: actions of ATP and UTP.
Life sciences 1997;60(17):1419-30.
1996: Pier Giovanni Baraldi; Barbara Cacciari; Alessandro Dalpiaz; S Dionisotti; C Zocchi; Maria Josè Pineda de las Infantas; Giampiero Spalluto; Katia Varani
1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one and 5H-pyrazolo[4,3-d] 1,2,3-triazin-4(3H)-one derivatives. Synthesis and in vitro biological activity at adenosine A1 and A2a receptors.
Arzneimittel-Forschung 1996;46(4):365-8.
1996: Katia Varani; Stefania Gessi; Alessandro Dalpiaz; Pier Andrea Borea
Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding.
British journal of pharmacology 1996;117(8):1693-701.
1996: Pier Andrea Borea; Alessandro Dalpiaz; Katia Varani; Stefania Gessi; G Gilli
Binding thermodynamics at A1 and A2A adenosine receptors.
Life sciences 1996;59(17):1373-88.
1995: Katia Varani; Lorenzo Beani; Clementina Bianchi; Pier Andrea Borea; Michele Simonato
Changes in [3H]-UK 14304 binding to alpha 2-adrenoceptors in morphine-dependent guinea-pigs.
British journal of pharmacology 1995;116(8):3125-32.
1995: Elisabetta Cerbai; L Guerra; Katia Varani; M Barbieri; Pier Andrea Borea; Alessandro Mugelli
Beta-adrenoceptor subtypes in young and old rat ventricular myocytes: a combined patch-clamp and binding study.
British journal of pharmacology 1995;116(2):1835-42.
1995: Alessandro Dalpiaz; Katia Varani; Pier Andrea Borea; C Martini; G Chiellini; A Lucacchini
Biochemical and pharmacological characterization of periodate-oxidized adenosine analogues at adenosine A1 receptors.
Biochimica et biophysica acta 1995;1267(2-3):145-51.
1995: Pier Andrea Borea; Alessandro Dalpiaz; Katia Varani; L Guerra; G Gilli
Binding thermodynamics of adenosine A2a receptor ligands.
Biochemical pharmacology 1995;49(4):461-9.
1994: Michele Simonato; Katia Varani; A Muzzolini; Clementina Bianchi; Lorenzo Beani; Pier Andrea Borea
Adenosine A1 receptors in the rat brain in the kindling model of epilepsy.
European journal of pharmacology 1994;265(3):121-4.
1994: Katia Varani; Pier Andrea Borea; L Guerra; S Dionisotti; C Zocchi; Ennio Ongini
Binding characteristics of the adenosine A2 receptor ligand [3H]CGS 21680 to human platelet membranes.
Biochemical pharmacology 1994;48(8):1658-61.
1994: M Barbieri; Katia Varani; Elisabetta Cerbai; L Guerra; Q Li; Pier Andrea Borea; Alessandro Mugelli
Electrophysiological basis for the enhanced cardiac arrhythmogenic effect of isoprenaline in aged spontaneously hypertensive rats.
Journal of molecular and cellular cardiology 1994;26(7):849-60.
1994: Pier Andrea Borea; Katia Varani; Alessandro Dalpiaz; Antonio Capuzzo; Elena Fabbri; A P IJzerman
Full and partial agonistic behaviour and thermodynamic binding parameters of adenosine A1 receptor ligands.
European journal of pharmacology 1994;267(1):55-61.
1992: S Dionisotti; C Zocchi; Katia Varani; Pier Andrea Borea; Ennio Ongini
Effects of adenosine derivatives on human and rabbit platelet aggregation. Correlation of adenosine receptor affinities and antiaggregatory activity.
Naunyn-Schmiedeberg's archives of pharmacology 1992;346(6):673-6.
1992: Pier Andrea Borea; Sandra Amerini; I Masini; Elisabetta Cerbai; F Ledda; L Mantelli; Katia Varani; Alessandro Mugelli
Beta 1- and beta 2-adrenoceptors in sheep cardiac ventricular muscle.
Journal of molecular and cellular cardiology 1992;24(7):753-63.
1991: Pier Andrea Borea; Katia Varani; V Malaguti; G Gilli
Receptor binding at two different temperatures to discriminate agonist and antagonist behaviour of adenosine A1 receptor ligands in rat brain.
The Journal of pharmacy and pharmacology 1991;43(12):866-8.
1991: M Trampus; Ennio Ongini; Katia Varani; Pier Andrea Borea
The neutral endopeptidase-24.11 inhibitor SCH 34826 does not change opioid binding but reduces D1 dopamine receptors in rat brain.
European journal of pharmacology 1991;194(1):17-23.