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Isabel Varela-Nieto

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Marta Magariños; María R Aburto; Julio Contreras; Isabel Varela-Nieto
Early development of the vertebrate inner ear.
L Rodriguez-de la Rosa; Isabel Varela-Nieto; Pedro de la Villa; L Fernandez-Sanchez; Francisco Germain; S Murillo-Cuesta; Nicolás Cuenca
Age-related functional and structural retinal modifications in the Igf1-/- null mouse.
Teresa Rivera; Lorena Sanz; Guadalupe Camarero; Isabel Varela-Nieto
Drug delivery to the inner ear: strategies and their therapeutic implications for sensorineural hearing loss.

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All Publications

2012: Marta Magariños; María R Aburto; Julio Contreras; Isabel Varela-Nieto
Early development of the vertebrate inner ear.
Anatomical record (Hoboken, N.J. : 2007) 2012;295(11):1775-90.
2012: L Rodriguez-de la Rosa; Isabel Varela-Nieto; Pedro de la Villa; L Fernandez-Sanchez; Francisco Germain; S Murillo-Cuesta; Nicolás Cuenca
Age-related functional and structural retinal modifications in the Igf1-/- null mouse.
Neurobiology of disease 2012;46(2):476-85.
2012: Teresa Rivera; Lorena Sanz; Guadalupe Camarero; Isabel Varela-Nieto
Drug delivery to the inner ear: strategies and their therapeutic implications for sensorineural hearing loss.
Current drug delivery 2012;9(3):231-42.
2012: Maria R Aburto; Yolanda Leon; Marta Magariños; Isabel Varela-Nieto; Hortensia Sanchez-Calderon
AKT signaling mediates IGF-I survival actions on otic neural progenitors.
PloS one 2012;7(1):e30790.
2012: Silvia Murillo-Cuesta; Angela M Valverde; Carlos Avendaño; Deborah J Burks; Guadalupe Camarero; Lourdes Rodríguez De La Rosa; Agueda González-Rodríguez; Isabel Varela-Nieto
Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function.
Molecular medicine (Cambridge, Mass.) 2012;18():260-9.
2011: Silvia Murillo-Cuesta; Lourdes Rodríguez-de la Rosa; Rafael Cediel; Luis Lassaletta; Isabel Varela-Nieto
The role of insulin-like growth factor-I in the physiopathology of hearing.
Frontiers in molecular neuroscience 2011;4():11.
2010: Outi Hovatta; Miodrag Stojkovic; Maria Nogueira; Isabel Varela-Nieto
European scientific, ethical, and legal issues on human stem cell research and regenerative medicine.
Stem cells (Dayton, Ohio) 2010;28(6):1005-7.
2010: Silvia Murillo-Cuesta; Julio Contreras; Esther Zurita; Rafael Cediel; Marta Cantero; Isabel Varela-Nieto; Lluis Montoliu
Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice.
Pigment cell & melanoma research 2010;23(1):72-83.
2010: Marta Magariños; María R Aburto; Hortensia Sanchez-Calderon; Carmen Muñoz-Agudo; Ulf R Rapp; Isabel Varela-Nieto
RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.
PloS one 2010;5(12):e14435.
2010: Raquel Riquelme; Rafael Cediel; Julio Contreras; Rodriguez-de la Rosa Lourdes; Silvia Murillo-Cuesta; Catalina Hernandez-Sanchez; Jose M Zubeldia; Sebastian Cerdan; Isabel Varela-Nieto
A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice.
Frontiers in neuroanatomy 2010;4():27.
2010: Hortensia Sanchez-Calderon; Lourdes Rodriguez-de la Rosa; Marta Milo; Jose G Pichel; Matthew Holley; Isabel Varela-Nieto
RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.
PloS one 2010;5(1):e8699.
2009: Silvia Murillo-Cuesta; Fernando García-Alcántara; Elena Vacas; Jon Alexander Sistiaga; Guadalupe Camarero; Isabel Varela-Nieto; Teresa Rivera
Direct drug application to the round window: a comparative study of ototoxicity in rats.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2009;141(5):584-90.
2009: Alberto Fernández-Medarde; Rima Barhoum; Raquel Riquelme; Angel Porteros; Alejandro Núñez; Alberto de Luis; Javier De Las Rivas; Pedro de la Villa; Isabel Varela-Nieto; Eugenio Santos
RasGRF1 disruption causes retinal photoreception defects and associated transcriptomic alterations.
Journal of neurochemistry 2009;110(2):641-52.
2008: Donald Bell; Andrea Streit; Itziar Gorospe; Isabel Varela-Nieto; BERTA Alsina; Fernando Giraldez
Spatial and temporal segregation of auditory and vestibular neurons in the otic placode.
Developmental biology 2008;322(1):109-20.
2007: L Rodríguez-de la Rosa; J Contreras-Rodríguez; R Cediel-Algovia; Yolanda León; Hortensia Sanchez-Calderon; S Murillo-Cuesta; R Riquelme-Galiana; Juan Ignacio de Diego Sastre; María Pilar Prim Espada; Isabel Varela-Nieto
[Neurotrophic action of insulin-like growth factor-I in the inner ear].
Revista de neurologia 2007;45(4):245-50.
2007: Hortensia Sanchez-Calderon; Marta Milo; Yolanda Leon; Isabel Varela-Nieto
A network of growth and transcription factors controls neuronal differentation and survival in the developing ear.
The International journal of developmental biology 2007;51(6-7):557-70.
2007: Isabel Varela-Nieto; Markus Hartl; Itziar Gorospe; Yolanda León
Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation.
Current pharmaceutical design 2007;13(7):687-703.
2006: R Cediel; R Riquelme; Julio Contreras; A Díaz; Isabel Varela-Nieto
Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness.
The European journal of neuroscience 2006;23(2):587-90.
2005: David R Jones; Covadonga Pañeda; Ana V Villar; Alicia Alonso; Félix M Goñi; Peter Bütikofer; Urs Brodbeck; Peter R Shepherd; Isabel Varela-Nieto
Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases.
FEBS letters 2005;579(1):59-65.
2005: Amelia Diaz-Casares; Yolanda Leon; Enrique J de la Rosa; Isabel Varela-Nieto
Regulation of vertebrate sensory organ development: a scenario for growth hormone and insulin-like growth factors action.
Advances in experimental medicine and biology 2005;567():221-42.
2004: Isabel Varela-Nieto; Jose A Morales-Garcia; Patricia Vigil; Amelia Diaz-Casares; Itziar Gorospe; Susana Sánchez-Galiano; Susana Cañon; Guadalupe Camarero; Julio Contreras; Rafael Cediel; Yolanda Leon
Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear.
Hearing research 2004;196(1-2):19-25.
2004: Inma Castilla-Cortazar; Nieves Diez; Maria Garcia Fernandez; Juan Enrique Puche; Fernando Diez-Caballero; Jorge Quiroga; Matias Diaz-Sanchez; Alberto Castilla; Amelia-Diaz Casares; Isabel Varela-Nieto; Jesus Prieto; Salvador Gonzalez-Baron
Hematotesticular barrier is altered from early stages of liver cirrhosis: effect of insulin-like growth factor 1.
World journal of gastroenterology : WJG 2004;10(17):2529-34.
2004: Inma Castilla-Cortázar; María Pascual; Elena Urdaneta; Javier Pardo; Juan Enrique Puche; Bárbara Vivas; Amelia Díaz-Casares; María García; Matías Díaz-Sánchez; Isabel Varela-Nieto; Alberto Castilla; Salvador González-Barón
Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I.
BMC gastroenterology 2004;4():12.
2004: Montserrat Marí; Anna Colell; Albert Morales; Covadonga Pañeda; Isabel Varela-Nieto; Carmen García-Ruiz; José C Fernández-Checa
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
The Journal of clinical investigation 2004;113(6):895-904.
2003: Guadalupe Camarero; Yolanda Leon; Itziar Gorospe; Flora de Pablo; BERTA Alsina; Fernando Giraldez; Isabel Varela-Nieto
Insulin-like growth factor 1 is required for survival of transit-amplifying neuroblasts and differentiation of otic neurons.
Developmental biology 2003;262(2):242-53.
2003: Isabel Varela-Nieto; Enrique J de la Rosa; Ana I Valenciano; Yolanda León
Cell death in the nervous system: lessons from insulin and insulin-like growth factors.
Molecular neurobiology 2003;28(1):23-50.
2003: M García-Fernández; Inma Castilla-Cortázar; Matías Díaz-Sánchez; F Díez Caballero; Alberto Castilla; A Díaz Casares; Isabel Varela-Nieto; Salvador González-Barón
Effect of IGF-I on total serum antioxidant status in cirrhotic rats.
Journal of physiology and biochemistry 2003;59(2):145-6.
2003: Laura Frago; Susana Cañón; Enrique J de la Rosa; Yolanda León; Isabel Varela-Nieto
Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I.
Journal of cell science 2003;116(Pt 3):475-86.
2003: BERTA Alsina; Fernando Giraldez; Isabel Varela-Nieto
Growth factors and early development of otic neurons: interactions between intrinsic and extrinsic signals.
Current topics in developmental biology 2003;57():177-206.
2002: María A Balboa; Isabel Varela-Nieto; Karin Killermann Lucas; Edward A Dennis
Expression and function of phospholipase A(2) in brain.
FEBS letters 2002;531(1):12-7.
2002: Guadalupe Camarero; M Angeles Villar; Julio Contreras; Carmen Fernández-Moreno; José G Pichel; Carlos Avendaño; Isabel Varela-Nieto
Cochlear abnormalities in insulin-like growth factor-1 mouse mutants.
Hearing research 2002;170(1-2):2-11.
2002: Covadonga Pañeda; Itziar Gorospe; Blanca Herrera; Toshikazu Nakamura; Isabel Fabregat; Isabel Varela-Nieto
Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation.
Hepatology (Baltimore, Md.) 2002;35(6):1381-91.
2002: Laura Colombaioni; Laura Frago; Isabel Varela-Nieto; Rossana Pesi; Mercedes Garcia-Gil
Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells.
Neurochemistry international 2002;40(4):327-36.
2001: Guadalupe Camarero; C Avendano; C Fernandez-Moreno; A Villar; Julio Contreras; Flora de Pablo; José G Pichel; Isabel Varela-Nieto
Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(19):7630-41.
2001: Covadonga Pañeda; Ana V Villar; Alicia Alonso; Félix M Goñi; F Varela; Urs Brodbeck; Yolanda León; Isabel Varela-Nieto; David R Jones
Purification and characterization of insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus sativus) seeds.
Molecular medicine (Cambridge, Mass.) 2001;7(7):454-60.
2001: Laura Frago; Covadonga Pañeda; Isabel Fabregat; Isabel Varela-Nieto
Short-chain ceramide regulates hepatic methionine adenosyltransferase expression.
Journal of hepatology 2001;34(2):192-201.
2000: B Pimentel; C Sanz; Isabel Varela-Nieto; U R Rapp; Flora de Pablo; Enrique J de la Rosa
c-Raf regulates cell survival and retinal ganglion cell morphogenesis during neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(9):3254-62.
2000: Laura Frago; G Camerero; Susana Cañón; Covadonga Pañeda; C Sanz; Yolanda Leon; Fernando Giraldez; Isabel Varela-Nieto
Role of diffusible and transcription factors in inner ear development: implications in regeneration.
Histology and histopathology 2000;15(2):657-66.
1999: C Sanz; Yolanda León; Susana Cañón; L Alvarez; Fernando Giraldez; Isabel Varela-Nieto
Pattern of expression of the jun family of transcription factors during the early development of the inner ear: implications in apoptosis.
Journal of cell science 1999;112 ( Pt 22)():3967-74.
1999: Ana V Villar; Alicia Alonso; Covadonga Pañeda; Isabel Varela-Nieto; Urs Brodbeck; Félix M Goñi
Towards the in vitro reconstitution of caveolae. Asymmetric incorporation of glycosylphosphatidylinositol (GPI) and gangliosides into liposomal membranes.
FEBS letters 1999;457(1):71-4.
1999: Isabel Varela-Nieto; I Silos-Santiago
Introduction to structural and functional studies on nerve growth factor.
Microscopy research and technique 1999;45(4-5):206.
1999: Yolanda León; C Sanz; Laura Frago; Guadalupe Camarero; Susana Cañón; Isabel Varela-Nieto; F Giráldez
Involvement of insulin-like growth factor-I in inner ear organogenesis and regeneration.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999;31(2-3):126-32.
1999: C Sanz; Yolanda León; J Troppmair; U R Rapp; Isabel Varela-Nieto
Strict regulation of c-Raf kinase levels is required for early organogenesis of the vertebrate inner ear.
Oncogene 1999;18(2):429-37.
1998: Yolanda León; C Sanz; F Giráldez; Isabel Varela-Nieto
Induction of cell growth by insulin and insulin-like growth factor-I is associated with Jun expression in the otic vesicle.
The Journal of comparative neurology 1998;398(3):323-32.
1998: Ana V Villar; Félix M Goñi; Alicia Alonso; David R Jones; Yolanda León; Isabel Varela-Nieto
Phospholipase cleavage of glycosylphosphatidylinositol reconstituted in liposomal membranes.
FEBS letters 1998;432(3):150-4.
1998: Laura Frago; A Giménez; E N Rodriguez; Isabel Varela-Nieto
Pattern of methionine adenosyltransferase isoenzyme expression during rat liver regeneration after partial hepatectomy.
FEBS letters 1998;426(3):305-8.
1998: D R Jones; Isabel Varela-Nieto
The role of glycosyl-phosphatidylinositol in signal transduction.
The international journal of biochemistry & cell biology 1998;30(3):313-26.
1998: Laura Frago; Yolanda León; Enrique J de la Rosa; A Gómez-Muñoz; Isabel Varela-Nieto
Nerve growth factor and ceramides modulate cell death in the early developing inner ear.
Journal of cell science 1998;111 ( Pt 5)():549-56.
1997: HN Caro; Sirilaksana Kunjara; Thomas W Rademacher; Yolanda León; David R Jones; M A Avila; Isabel Varela-Nieto
Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver.
Biochemical and molecular medicine 1997;61(2):214-28.
1997: A Gomez-Muñoz; Laura Frago; L Alvarez; Isabel Varela-Nieto
Stimulation of DNA synthesis by natural ceramide 1-phosphate.
The Biochemical journal 1997;325 ( Pt 2)():435-40.
1997: D R Jones; M A Avila; C Sanz; Isabel Varela-Nieto
Glycosyl-phosphatidylinositol-phospholipase type D: a possible candidate for the generation of second messengers.
Biochemical and biophysical research communications 1997;233(2):432-7.
1997: Yolanda Leon; Isabel Varela-Nieto; Kieran C Breen
Neural cell adhesion molecule expression in the developing chick otic vesicle.
Biochemical Society transactions 1997;25(1):10S.
1996: Isabel Varela-Nieto; Yolanda León; H N Caro
Cell signalling by inositol phosphoglycans from different species.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1996;115(2):223-41.
1996: C Sanz; Y Leon; M Garcia-Gil; Isabel Varela-Nieto
Role of Raf kinases during inner ear development.
The International journal of developmental biology 1996;Suppl 1():83S-84S.
1995: Yolanda León; E Vazquez; C Sanz; J A Vega; José M Mato; F Giraldez; J Represa; Isabel Varela-Nieto
Insulin-like growth factor-I regulates cell proliferation in the developing inner ear, activating glycosyl-phosphatidylinositol hydrolysis and Fos expression.
Endocrinology 1995;136(8):3494-503.
1995: R Clemente; D R Jones; P Ochoa; G Romero; José M Mato; Isabel Varela-Nieto
Role of glycosyl-phosphatidylinositol hydrolysis as a mitogenic signal for epidermal growth factor.
Cellular signalling 1995;7(4):411-21.
1995: Y Leon; C Sanz; Isabel Varela-Nieto
Intracellular mediators of insulin-like growth factor I during otic vesicle development.
Biochemical Society transactions 1995;23(2):185S.
1995: D R Jones; R Clemente; Isabel Varela-Nieto
Signalling at the epidermal growth factor receptor: role of glycosylphosphatidylinositol hydrolysis.
Biochemical Society transactions 1995;23(2):174S.
1994: A Zapata; Yolanda León; José M Mato; Isabel Varela-Nieto; S Penadés; M Martín-Lomas
Synthesis and investigation of the possible insulin-like activity of 1D-4-O- and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1-phosphate and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1,2-(cyclic phosphate).
Carbohydrate research 1994;264(1):21-31.
1994: Matías A Avila; R Clemente; Isabel Varela-Nieto
Mannosamine is an unspecific inhibitor of glycosyl-phosphatidylinositol biosynthesis in T-lymphocytes.
Biochemical Society transactions 1994;22(1):11S.
1993: Matías A Avila; Isabel Varela-Nieto; G Romero; José M Mato; F Giraldez; Thomas R Van De Water; J Represa
Brain-derived neurotrophic factor and neurotrophin-3 support the survival and neuritogenesis response of developing cochleovestibular ganglion neurons.
Developmental biology 1993;159(1):266-75.
1993: J Represa; Matías A Avila; G Romero; José M Mato; F Giraldez; Isabel Varela-Nieto
Brain-derived neurotrophic factor and neurotrophin-3 induce cell proliferation in the cochleovestibular ganglion through a glycosyl-phosphatidylinositol signaling system.
Developmental biology 1993;159(1):257-65.
1992: Valeria Vasta; Paola Bruni; R Clemente; F Vannini; P Ochoa; G Romero; Marta Farnararo; Isabel Varela-Nieto
Role of the glycosylphosphatidylinositol/inositol phosphoglycan system in human fibroblast proliferation.
Experimental cell research 1992;200(2):439-43.
1992: Matías A Avila; R Clemente; Isabel Varela-Nieto
A phosphatidylinositol-linkage-deficient T-cell mutant contains insulin-sensitive glycosyl-phosphatidylinositol.
The Biochemical journal 1992;282 ( Pt 3)():681-6.
1991: Paola Bruni; Valeria Vasta; L Berti; Matías A Avila; Marta Farnararo; Isabel Varela-Nieto
An inositol phosphoglycan stimulates glycolysis in human platelets.
Biochemical and biophysical research communications 1991;180(2):1041-7.
1991: J Represa; Matías A Avila; C Miner; F Giraldez; G Romero; R Clemente; José M Mato; Isabel Varela-Nieto
Glycosyl-phosphatidylinositol/inositol phosphoglycan: a signaling system for the low-affinity nerve growth factor receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8016-9.
1991: L Alvarez; Matías A Avila; José M Mato; J G Castaño; Isabel Varela-Nieto
Insulin-like effects of inositol phosphate-glycan on messenger RNA expression in rat hepatocytes.
Molecular endocrinology (Baltimore, Md.) 1991;5(8):1062-8.
1991: Isabel Varela-Nieto; J Represa; Matías A Avila; C Miner; José M Mato; F Giraldez
Inositol phospho-oligosaccharide stimulates cell proliferation in the early developing inner ear.
Developmental biology 1991;143(2):432-5.