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Marileila Varella-Garcia

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Andrew J Weickhardt; Dara L Aisner; Robert C Doebele; Wilbur A Franklin; Marileila Varella-Garcia; D Ross Camidge
Diagnostic assays for identification of anaplastic lymphoma kinase-positive non-small cell lung cancer.
Todd M Pitts; Heather M Selby; Anna Spreafico; Aik Choon Tan; John J Tentler; Marileila Varella-Garcia; John Arcaroli; Erica L Bradshaw-Pierce; Blair C Britt; Maria I Kachaeva; Gillian N Kulikowski; Kelly L McPhillips; Wells A Messersmith; Brion W Murray; S Gail Eckhardt
Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.
Xiaoping Yang; Arthur E Frankel; L Michael Glodé; Elizabeth Kessler; Francisco G La Rosa; Chuan-Yuan Li; Yuan Li; Jingping Shen; Lih-Jen Su; Andrew Thorburn; Marileila Varella-Garcia; Thomas W Flaig
Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer.

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2013: Andrew J Weickhardt; Dara L Aisner; Robert C Doebele; Wilbur A Franklin; Marileila Varella-Garcia; D Ross Camidge
Diagnostic assays for identification of anaplastic lymphoma kinase-positive non-small cell lung cancer.
Cancer 2013;119(8):1467-77.
2013: Todd M Pitts; Heather M Selby; Anna Spreafico; Aik Choon Tan; John J Tentler; Marileila Varella-Garcia; John Arcaroli; Erica L Bradshaw-Pierce; Blair C Britt; Maria I Kachaeva; Gillian N Kulikowski; Kelly L McPhillips; Wells A Messersmith; Brion W Murray; S Gail Eckhardt
Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.
Frontiers in pharmacology 2013;4():35.
2013: Xiaoping Yang; Arthur E Frankel; L Michael Glodé; Elizabeth Kessler; Francisco G La Rosa; Chuan-Yuan Li; Yuan Li; Jingping Shen; Lih-Jen Su; Andrew Thorburn; Marileila Varella-Garcia; Thomas W Flaig
Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(1):148-57.
2013: Jennifer R Diamond; S Gail Eckhardt; Graham C Fletcher; Maria I Kachaeva; Timothy P Newton; Todd M Pitts; Heather M Selby; Aik Choon Tan; Mark R Bray; Kelsey L Brunkow; Marileila Varella-Garcia; John J Tentler
Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(1):291-303.
2012: Rosana Cardoso Manique Rosa; Rafael Fabiano Machado Rosa; Marileila Varella-Garcia; José Antônio Monteiro Flores; Eliete Golendziner; Ceres Andréia Vieira de Oliveira; Giorgio Adriano Paskulin; Paulo Ricardo Gazzola Zen
Malformations detected by abdominal ultrasound in children with congenital heart disease.
Arquivos brasileiros de cardiologia 2012;99(6):1092-9.
2012: Anh T Le; Marileila Varella-Garcia; Robert C Doebele
Oncogenic fusions involving exon 19 of ALK.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(12):e44; author reply e44.
2012: D Ross Camidge; Jeffrey W Clark; Daniel B Costa; Jeffrey A Engelman; Panagiotis Fidias; Stephen B Fox; Leena Gandhi; A John Iafrate; Pasi A Janne; Dong-Wan Kim; Eunice L Kwak; Patricia M LoRusso; Sai-Hong I Ou; Gregory J Riely; Katherine Ruffner; Ravi Salgia; Geoffrey I Shapiro; Benjamin Solomon; Patricia Stephenson; Yiyun Tang; Marileila Varella-Garcia; Keith Wilner; Yung-Jue Bang; Alice T Shaw
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study.
The lancet oncology 2012;13(10):1011-9.
2012: D Ross Camidge; Robert C Doebele; Xian Lu; Delee A Maxson; Tara O'Brien; Margaret Skokan; Mariana Theodoro; Anna E Barón; Marileila Varella-Garcia
Correlations between the percentage of tumor cells showing an anaplastic lymphoma kinase (ALK) gene rearrangement, ALK signal copy number, and response to crizotinib therapy in ALK fluorescence in situ hybridization-positive nonsmall cell lung cancer.
Cancer 2012;118(18):4486-94.
2012: Robert C Doebele; Wilbur A Franklin; Xian Lu; Delee A Maxson; Ana B Oton; Christopher Sumey; Marileila Varella-Garcia; Andrew J Weickhardt; Dara L Aisner; Anna E Barón; Paul A Bunn; D Ross Camidge
Oncogene status predicts patterns of metastatic spread in treatment-naive nonsmall cell lung cancer.
Cancer 2012;118(18):4502-11.
2012: Kurtis D Davies; Dara L Aisner; Marco Alloisio; Eamon M Berge; D Ross Camidge; Federico Cappuzzo; Matteo Incarbone; Anh T Le; Massimo Roncalli; Armando Santoro; Margaret C Skokan; Luigi M Terracciano; Mariana F Theodoro; Marileila Varella-Garcia; Robert C Doebele
Identifying and targeting ROS1 gene fusions in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(17):4570-9.
2012: Nir Peled; Jeffrey S Ross; Lior Soussan-Gutman; Philip J Stephens; Marileila Varella-Garcia; Murry W Wynes; Maureen T Cronin; Fred R Hirsch; Maya Ilouze; Doron Lipson; Geoff A Otto; Gary Palmer; Vincent A Miller
Next-generation sequencing identifies and immunohistochemistry confirms a novel crizotinib-sensitive ALK rearrangement in a patient with metastatic non-small-cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(9):e14-6.
2012: Agnes Cristina Fett-Conte; Paula C Freitas; Patrícia Pedrassa; Andréa B Carvalho-Salles; Cristina B Vendrame; Marileila Varella-Garcia
New complex chromosome abnormalities in multiple myeloma associated with a poor prognosis: a case report.
Leukemia research 2012;36(7):e140-2.
2012: Samir E Witta; Paul A Bunn; Robert M Jotte; Katrik Konduri; Marcus A Neubauer; Robert L Ruxer; Alexander I Spira; Marileila Varella-Garcia; Fred R Hirsch
Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(18):2248-55.
2012: John Arcaroli; Arvind Dasari; Dexiang Gao; Martine McManus; Todd M Pitts; Rebecca W Powell; Kevin S Quackenbush; Anna Spreafico; Aik Choon Tan; Basel M Touban; Marileila Varella-Garcia; Wells A Messersmith
ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer.
Molecular oncology 2012;6(3):370-81.
2012: John Arcaroli; Lynne Bemis; Arvind Dasari; S Gail Eckhardt; Todd M Pitts; Rebecca W Powell; Kevin S Quackenbush; Jaclyn M Reinemann; Anna Spreafico; Aik Choon Tan; Basel M Touban; Marileila Varella-Garcia; Wells A Messersmith
Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(9):2704-14.
2012: Wilbur A Franklin; Dara L Aisner; Marileila Varella-Garcia
Prognostic patterns in the histopathology of pulmonary adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(13):1401-3.
2012: Federico Cappuzzo; Yong Gon Cho; Annarita Destro; Gabriella Fontanini; Matteo Incarbone; Antonio Marchetti; Massimo Roncalli; Andrea Sacconi; Olimpia Siclari; Luigi Terracciano; Greta Alì; Marileila Varella-Garcia
p95HER2 truncated form in resected non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(3):520-7.
2012: Robert C Doebele; Wilbur A Franklin; Lynn E Heasley; Kimi L Kondo; Tatiana G Kutateladze; Anh T Le; Derek J Linderman; Amanda B Pilling; Marileila Varella-Garcia; Andrew J Weickhardt; Dara L Aisner; D Ross Camidge
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(5):1472-82.
2012: Andrea Sartore-Bianchi; Margaret Skokan; Sabine Tejpar; Valter Torri; Sara Vander Borght; Marileila Varella-Garcia; Silvio Veronese; Federico Cappuzzo; Steffen Fieuws; Milo Frattini; Marcello Gambacorta; Vittoria Martin; Mauro Moroni; Nicola Personeni; Armando Santoro; Salvatore Siena
Standardisation of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study.
Journal of clinical pathology 2012;65(3):218-23.
2012: Andrew Weickhardt; Murry W Wynes; Hagop Youssoufian; Araba Adjei; Alex Adjei; Amy Brown; Robert Doebele; Grace Dy; Gerald Fetterly; Wilbur Franklin; Fred R Hirsch; Mary K Jackson; Janice Lettieri; Xian Lu; DeLee Maxson; Ana Oton; Michele Reynolds; Marileila Varella-Garcia; D Ross Camidge
A phase I/II study of erlotinib in combination with the anti-insulin-like growth factor-1 receptor monoclonal antibody IMC-A12 (cixutumumab) in patients with advanced non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(2):419-26.
2012: Marilanda Ferreira Bellini; Maria Tercília Vilela de Azeredo-Oliveira; Rosana Silistino-Souza; Marileila Varella-Garcia; Ana Elizabete Silva
Biologic and genetics aspects of chagas disease at endemic areas.
Journal of tropical medicine 2012;2012():357948.
2011: Adela Cota-Gomez; Ariana C Flores; Xiao-Feng Ling; Marileila Varella-Garcia; Sonia C Flores
HIV-1 Tat increases oxidant burden in the lungs of transgenic mice.
Free radical biology & medicine 2011;51(9):1697-707.
2011: Alice T Shaw; Benjamin J Solomon; Yiyun Tang; Marileila Varella-Garcia; Keith D Wilner; Beow Y Yeap; Yung-Jue Bang; Mohit Butaney; Jeffrey W Clark; Daniel B Costa; Robert C Doebele; Jeffrey A Engelman; Justin Gainor; A John Iafrate; Kimary Kulig; Eunice L Kwak; ROBERT G MAKI; Sai-Hong I Ou; Gregory J Riely; Ravi Salgia; Paulina Selaru; Geoffrey I Shapiro; D Ross Camidge
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis.
The lancet oncology 2011;12(11):1004-12.
2011: Thomas W Flaig; E Erin Genova; Paul D Maroni; Diana Morales; Adrie van Bokhoven; Marileila Varella-Garcia; Shandra Wilson; Pamela Wolfe; M Scott Lucia
Detection of circulating tumor cells in metastatic and clinically localized urothelial carcinoma.
Urology 2011;78(4):863-7.
2011: Fred R Hirsch; Fairooz Kabbinavar; Renato Martins; Frank Richardson; Katherine Richardson; Jason Rusk; Fredrick M Schnell; David W Sternberg; Marileila Varella-Garcia; Bret Wacker; Paul A Bunn; D Ross Camidge; Rafal Dziadziuszko; Tim Eisen; Wilbur A Franklin; D Ross Camidge
A randomized, phase II, biomarker-selected study comparing erlotinib to erlotinib intercalated with chemotherapy in first-line therapy for advanced non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(26):3567-73.
2011: Fei Yang; Ximing Tang; Erick Riquelme; Carmen Behrens; Monique B Nilsson; Uma Giri; Marileila Varella-Garcia; Lauren A Byers; Heather Y Lin; Jing Wang; Maria G Raso; Luc Girard; Kevin Coombes; J Jack Lee; Roy S Herbst; John D Minna; John V Heymach; Ignacio I Wistuba
Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy.
Cancer research 2011;71(16):5512-21.
2011: Rafael Fabiano Machado Rosa; Marileila Varella-Garcia; Rita Carolina Pozzer Krumenauer; Rosana Cardoso Manique Rosa; Giorgio Adriano Paskulin
Anterior laryngeal membrane and 22q11 deletion syndrome.
Brazilian journal of otorhinolaryngology 2011;77(4):540.
2011: Ximing Tang; Humam Kadara; Carmen Behrens; Diane D Liu; Yun Xiao; David Rice; Adi F Gazdar; Junya Fujimoto; Cesar Moran; Marileila Varella-Garcia; J Jack Lee; Waun Ki Hong; Ignacio I Wistuba
Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: implications in lung cancer pathogenesis and prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2434-43.
2011: D Ross Camidge; Scott A Kono; Xian Lu; Sonia Okuyama; Anna E Barón; Ana B Oton; Angela M Davies; Marileila Varella-Garcia; Wilbur Franklin; Robert C Doebele
Anaplastic lymphoma kinase gene rearrangements in non-small cell lung cancer are associated with prolonged progression-free survival on pemetrexed.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(4):774-80.
2011: D Ross Camidge; Fred R Hirsch; Marileila Varella-Garcia; Wilbur A Franklin
Finding ALK-positive lung cancer: what are we really looking for?
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(3):411-3.
2011: Wei Guo; Suzanne Schubbert; James Y Chen; Bahram Valamehr; Sherly Mosessian; Hubing Shi; Nhi H Dang; Consuelo Garcia; Mariana F Theodoro; Marileila Varella-Garcia; Hong Wu
Suppression of leukemia development caused by PTEN loss.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1409-14.
2011: Rafael Fabiano Machado Rosa; Patrícia Trevisan; Dayane Bohn Koshiyama; Carlo Benatti Pilla; Paulo Ricardo Gazzola Zen; Marileila Varella-Garcia; Giorgio Adriano Paskulin
[22q11.2 deletion syndrome and complex congenital heart defects].
Revista da Associação Médica Brasileira (1992) 2011;57(1):62-5.
2010: D Ross Camidge; Scott A Kono; Antonella Flacco; Aik Choon Tan; Robert C Doebele; Qing Zhou; Lucio Crino; Wilbur A Franklin; Marileila Varella-Garcia
Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(22):5581-90.
2010: Micheala A Aldred; Suzy A Comhair; Marileila Varella-Garcia; Kewal Asosingh; Weiling Xu; George P Noon; Patricia A Thistlethwaite; Rubin M Tuder; Serpil C Erzurum; Mark W Geraci; Christopher Coldren
Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2010;182(9):1153-60.
2010: Rafael Fabiano Machado Rosa; Paulo Ricardo Gazzola Zen; José Antônio Monteiro Flores; Eliete Golendziner; Carlo Benatti Pilla; Tatiana Roman; Marileila Varella-Garcia; Giorgio Adriano Paskulin
[Oculo-auriculo-vertebral spectrum in patients with congenital heart defects].
Arquivos brasileiros de cardiologia 2010;95(4):436-9.
2010: Susan M Majka; Keith E Fox; John C Psilas; Karen M Helm; Christine R Childs; Alistaire S Acosta; Rachel C Janssen; Jacob E Friedman; Brian T Woessner; Theodore R Shade; Marileila Varella-Garcia; Dwight J Klemm
De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(33):14781-6.
2010: John J Arcaroli; Basel M Touban; Aik Choon Tan; Marileila Varella-Garcia; Rebecca W Powell; S Gail Eckhardt; Paul Elvin; Dexiang Gao; Wells A Messersmith
Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib (AZD0530), a Src inhibitor, in a preclinical model of colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(16):4165-77.
2010: Paul A Bunn; Fred R Hirsch; Robert C Doebele; D Ross Camidge; Marileila Varella-Garcia; Wilbur Franklin
Biomarkers are here to stay for clinical research and standard care.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(8):1113-5.
2010: Todd M Pitts; Aik Choon Tan; Gillian N Kulikowski; John J Tentler; Amy M Brown; Sara A Flanigan; Stephen Leong; Christopher D Coldren; Fred R Hirsch; Marileila Varella-Garcia; Christopher Korch; S Gail Eckhardt
Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(12):3193-204.
2010: Rafal Dziadziuszko; Daniel T Merrick; Samir E Witta; Adelita D Mendoza; Barbara Szostakiewicz; Amelia Szymanowska; Witold Rzyman; Katarzyna Dziadziuszko; Jacek Jassem; Paul A Bunn; Marileila Varella-Garcia; Fred R Hirsch
Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: a comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(13):2174-80.
2010: Marilanda Ferreira Bellini; Ana Elizabete Silva; Marileila Varella-Garcia
Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques.
Genetics and molecular biology 2010;33(2):205-13.
2010: Marileila Varella-Garcia; Aline P Schulte; Holly J Wolf; William J Feser; Chan Zeng; Sarah Braudrick; Xiang Yin; Fred R Hirsch; Timothy C Kennedy; Robert L Keith; Anna E Barón; Steven A Belinsky; York E Miller; Tim Byers; Wilbur A Franklin
The detection of chromosomal aneusomy by fluorescence in situ hybridization in sputum predicts lung cancer incidence.
Cancer prevention research (Philadelphia, Pa.) 2010;3(4):447-53.
2010: Federico Cappuzzo; Giovanni Tallini; Giovanna Finocchiaro; R S Wilson; Claudia Ligorio; L Giordano; Luca Toschi; M Incarbone; R Cavina; L Terracciano; M Roncalli; M Alloisio; Marileila Varella-Garcia; Wilbur A Franklin; A Santoro
Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small-cell lung cancer (NSCLC) patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2010;21(3):562-7.
2010: Marilanda F Bellini; Antonio J Manzato; Ana E Silva; Marileila Varella-Garcia
Chromosomal imbalances are uncommon in chagasic megaesophagus.
BMC gastroenterology 2010;10():20.
2010: Marileila Varella-Garcia
Chromosomal and genomic changes in lung cancer.
Cell adhesion & migration 2010;4(1):100-6.
2009: Benjamin Solomon; Marileila Varella-Garcia; D Ross Camidge
ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009;4(12):1450-4.
2009: Rom S Leidner; Pingfu Fu; Bradley Clifford; Ayad Hamdan; Cheng Jin; Rosana Eisenberg; Titus Boggon; Margaret Skokan; Wilbur A Franklin; Federico Cappuzzo; Fred R Hirsch; Marileila Varella-Garcia; Balazs Halmos
Genetic abnormalities of the EGFR pathway in African American Patients with non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(33):5620-6.
2009: Marileila Varella-Garcia; J Diebold; D A Eberhard; K Geenen; A Hirschmann; M Kockx; I Nagelmeier; J Rüschoff; M Schmitt; S Arbogast; Federico Cappuzzo
EGFR fluorescence in situ hybridisation assay: guidelines for application to non-small-cell lung cancer.
Journal of clinical pathology 2009;62(11):970-7.
2009: Fred R Hirsch; Marileila Varella-Garcia; Federico Cappuzzo
Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer.
Oncogene 2009;28 Suppl 1():S32-7.
2009: Menghong Sun; Carmen Behrens; Lei Feng; Natalie Ozburn; Ximing Tang; Guosheng Yin; Ritsuko Komaki; Marileila Varella-Garcia; Waun Ki Hong; Kenneth Aldape; Ignacio I Wistuba
HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(15):4829-37.
2009: Dayane Bohn Koshiyama; Rafael Fabiano Machado Rosa; Paulo Ricardo Gazzola Zen; Vera Lúcia Berenstein Pereira; Carla Graziadio; Virgínia Maria Cóser; Cláudia Pires Ricachinevsky; Marileila Varella-Garcia; Giorgio Adriano Paskulin
[22q11.2 deletion syndrome: importance of clinical evaluation and FISH analysis].
Revista da Associação Médica Brasileira (1992) 2009;55(4):442-6.
2009: D Mark Hickinson; Gayle B Marshall; Garry J Beran; Marileila Varella-Garcia; Elizabeth A Mills; Marie C South; Andrew M Cassidy; Kerry L Acheson; Gael McWalter; Rose M McCormack; Paul A Bunn; Tim French; Alex Graham; Brian R Holloway; Fred R Hirsch; Georgina Speake
Identification of biomarkers in human head and neck tumor cell lines that predict for in vitro sensitivity to gefitinib.
Clinical and translational science 2009;2(3):183-92.
2009: Thomas W Flaig; Lih-Jen Su; Caroline McCoach; Yuan Li; David Raben; Marileila Varella-Garcia; Lynne T Bemis
Dual epidermal growth factor receptor and vascular endothelial growth factor receptor inhibition with vandetanib sensitizes bladder cancer cells to cisplatin in a dose- and sequence-dependent manner.
BJU international 2009;103(12):1729-37.
2009: Glenwood Goss; David Ferry; Rafal Wierzbicki; Scott A Laurie; Joyce Thompson; Bonne Biesma; Fred R Hirsch; Marileila Varella-Garcia; Emma Duffield; Ozlem U Ataman; Marc Zarenda; Alison A Armour
Randomized phase II study of gefitinib compared with placebo in chemotherapy-naive patients with advanced non-small-cell lung cancer and poor performance status.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(13):2253-60.
2009: Takafumi Kubo; Hiromasa Yamamoto; William W Lockwood; Ilse Valencia; Junichi Soh; Michael Peyton; Masaru Jida; Hiroki Otani; Tetsuya Fujii; Mamoru Ouchida; Nagio Takigawa; Katsuyuki Kiura; Kenji Shimizu; Hiroshi Date; John D Minna; Marileila Varella-Garcia; Wan L Lam; Adi F Gazdar; Shinichi Toyooka
MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors.
International journal of cancer. Journal international du cancer 2009;124(8):1778-84.
2009: J Simon W Stewart; Ezra E W Cohen; Lisa Licitra; Carla M L Van Herpen; Chonlakiet Khorprasert; Denis Soulieres; Pavel Vodvarka; Danny Rischin; Avgust M Garin; Fred R Hirsch; Marileila Varella-Garcia; Serban Ghiorghiu; Laura Hargreaves; Alison Armour; Georgina Speake; Alan Swaisland; Everett E Vokes
Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected].
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(11):1864-71.
2009: Federico Cappuzzo; Antonio Marchetti; Margaret Skokan; Elisa Rossi; Sujatha Gajapathy; Lara Felicioni; Maela Del Grammastro; Maria Grazia Sciarrotta; Fiamma Buttitta; Matteo Incarbone; Luca Toschi; Giovanna Finocchiaro; Annarita Destro; Luigi Terracciano; Massimo Roncalli; Marco Alloisio; Armando Santoro; Marileila Varella-Garcia
Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(10):1667-74.
2009: Federico Cappuzzo; Marileila Varella-Garcia; Elisa Rossi; Sujatha Gajapathy; Marialuisa Valente; Harry A Drabkin; Robert M Gemmill
MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009;4(4):472-8.
2009: Marileila Varella-Garcia; Tetsuya Mitsudomi; Yashushi Yatabe; Takayuki Kosaka; Eiji Nakajima; Ana Carolina Xavier; Margaret Skokan; Chan Zeng; Wilbur A Franklin; Paul A Bunn; Fred R Hirsch
EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery: impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009;4(3):318-25.
2009: Federico Cappuzzo; Pasi A Janne; M Skokan; Giovanna Finocchiaro; Elisa Rossi; Claudia Ligorio; P A Zucali; L Terracciano; Luca Toschi; M Roncalli; A Destro; M Incarbone; M Alloisio; A Santoro; Marileila Varella-Garcia
MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2009;20(2):298-304.
2009: Junichi Soh; Naoki Okumura; William W Lockwood; Hiromasa Yamamoto; Hisayuki Shigematsu; Wei Zhang; Raj Chari; David S Shames; Ximing Tang; Calum MacAulay; Marileila Varella-Garcia; Tõnu Vooder; Ignacio I Wistuba; Stephen Lam; Rolf Brekken; Shinichi Toyooka; John D Minna; Wan L Lam; Adi F Gazdar
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.
PloS one 2009;4(10):e7464.
2009: Pierre P Massion; Yong Zou; Hasmet Uner; Porntip Kiatsimkul; Holly J Wolf; Anna E Baron; Tim E Byers; Steinn Jonsson; Stephen Lam; Fred R Hirsch; York E Miller; Wilbur A Franklin; Marileila Varella-Garcia
Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer.
PloS one 2009;4(6):e5611.
2009: Jeet Gandhi; Jianling Zhang; Yang Xie; Junichi Soh; Hisayuki Shigematsu; Wei Zhang; Hiromasa Yamamoto; Michael Peyton; Luc Girard; William W Lockwood; Wan L Lam; Marileila Varella-Garcia; John D Minna; Adi F Gazdar
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
PloS one 2009;4(2):e4576.
2008: Susan M Majka; M Skokan; L Wheeler; Julie Harral; S Gladson; E Burnham; James E Loyd; Kurt R Stenmark; Marileila Varella-Garcia; James West
Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension.
American journal of physiology. Lung cellular and molecular physiology 2008;295(6):L1028-39.
2008: Fred R Hirsch; Marileila Varella-Garcia; Rafal Dziadziuszko; Yun Xiao; Sujatha Gajapathy; Margaret Skokan; Ming Lin; Vincent O'Neill; Paul A Bunn
Fluorescence in situ hybridization subgroup analysis of TRIBUTE, a phase III trial of erlotinib plus carboplatin and paclitaxel in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(19):6317-23.
2008: Lucio Crinò; Federico Cappuzzo; Petr Zatloukal; Martin Reck; Milos Pesek; Joyce C Thompson; Hugo Ford; Fred R Hirsch; Marileila Varella-Garcia; Serban Ghiorghiu; Emma L Duffield; Alison A Armour; Georgina Speake; Michael Cullen
Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): a randomized, phase II study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(26):4253-60.
2008: Ximing Tang; Marileila Varella-Garcia; Ana C Xavier; Erminia Massarelli; Natalie Ozburn; Cesar Moran; Ignacio I Wistuba
Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas.
Cancer prevention research (Philadelphia, Pa.) 2008;1(3):192-200.
2008: Fred R Hirsch; Roy S Herbst; Christine Olsen; Kari Chansky; John Crowley; Karen Kelly; Wilbur A Franklin; Paul A Bunn; Marileila Varella-Garcia; David R Gandara
Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(20):3351-7.
2008: Rafael F M Rosa; Carlo B Pilla; Vera L B Pereira; José A M Flores; Eliete Golendziner; Dayane B Koshiyama; Michele T Hertz; Cláudia P Ricachinevsky; Tatiana Roman; Marileila Varella-Garcia; Giorgio A Paskulin
22q11.2 deletion syndrome in patients admitted to a cardiac pediatric intensive care unit in Brazil.
American journal of medical genetics. Part A 2008;146A(13):1655-61.
2008: Fred R Hirsch; Rafal Dziadziuszko; Marileila Varella-Garcia; Wilbur A Franklin; David R Gandara; Paul A Bunn
First-generation epidermal growth factor receptor inhibitors in non-small cell lung cancer: clinical impact of the epidermal growth factor receptor fluorescence in situ hybridization assay.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(6 Suppl 2):S138-42.
2008: Wei Guo; Joseph L Lasky; Chun-Ju Chang; Sherly Mosessian; Xiaoman Lewis; Yun Xiao; Jennifer E Yeh; James Y Chen; M Luisa Iruela-Arispe; Marileila Varella-Garcia; Hong Wu
Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation.
Nature 2008;453(7194):529-33.
2008: Antonio Jimeno; Aik Choon Tan; Jordy Coffa; RAJESH KUMAR NV; Piotr Kulesza; Belen Rubio-Viqueira; Jenna Wheelhouse; Begoña Diosdado; Wells A Messersmith; Christine A Iacobuzio-Donahue; Anirban Maitra; Marileila Varella-Garcia; Fred R Hirsch; Gerrit A Meijer; Manuel Hidalgo
Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer.
Cancer research 2008;68(8):2841-9.
2008: Ricardo D Coletta; Kimberly L Christensen; Douglas S Micalizzi; Paul Jedlicka; Marileila Varella-Garcia; Heide L Ford
Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation.
Cancer research 2008;68(7):2204-13.
2008: C-h Zhong; Victor Prima; X Liang; C Frye; L McGavran; L Meltesen; Q Wei; T Boomer; Marileila Varella-Garcia; J Gump; Stephen P Hunger
E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3; p13.3) in acute leukemia.
Leukemia 2008;22(4):723-9.
2008: Steinn Jonsson; Marileila Varella-Garcia; York E Miller; Holly J Wolf; Tim E Byers; Sarah Braudrick; Porntip Kiatsimkul; Marina Lewis; Timothy C Kennedy; Robert L Keith; Johannes Bjornsson; Annette McWilliams; Stephen Lam; Fred R Hirsch; Wilbur A Franklin
Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer.
American journal of respiratory and critical care medicine 2008;177(3):342-7.
2007: Marileila Varella-Garcia; Lin Chen; Roger L Powell; Fred R Hirsch; Timothy C Kennedy; Robert L Keith; York E Miller; John D Mitchell; Wilbur A Franklin
Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer.
American journal of respiratory and critical care medicine 2007;176(5):505-12.
2007: Lynne Bemis; William A Robinson; Robert McFarlane; Elizabeth Buyers; Karen Kelly; Marileila Varella-Garcia; John D Mitchell; Wilbur A Franklin
EGFR-mutant lung adenocarcinoma in a patient with Li-Fraumeni syndrome.
The lancet oncology 2007;8(6):559-60.
2007: Federico Cappuzzo; Claudia Ligorio; Pasi A Janne; Luca Toschi; Elisa Rossi; Rocco Trisolini; Daniela Paioli; Alison J Holmes; Elisabetta Magrini; Giovanna Finocchiaro; Stefania Bartolini; Alessandra Cancellieri; Fortunato Ciardiello; Marco Patelli; Lucio Crino; Marileila Varella-Garcia
Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(16):2248-55.
2007: Erminia Massarelli; Marileila Varella-Garcia; Ximing Tang; Ana C Xavier; Natalie Ozburn; Diane D Liu; B Nebiyou Bekele; Roy S Herbst; Ignacio I Wistuba
KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):2890-6.
2007: Federico Cappuzzo; Claudia Ligorio; Claudio Ligorio; Luca Toschi; Elisa Rossi; Rocco Trisolini; Daniela Paioli; Elisabetta Magrini; Giovanna Finocchiaro; Stefania Bartolini; Alessandra Cancellieri; Fred R Hirsch; Lucio Crino; Marileila Varella-Garcia
EGFR and HER2 gene copy number and response to first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC).
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2007;2(5):423-9.
2007: Fred R Hirsch; Marileila Varella-Garcia; Federico Cappuzzo; Jason McCoy; Lynne Bemis; A C Xavier; Rafal Dziadziuszko; Paul H Gumerlock; Kari Chansky; Howard L West; Adi F Gazdar; Lucio Crino; David R Gandara; Wilbur A Franklin; Paul A Bunn
Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(4):752-60.
2007: Robert Stearman; Michael C Grady; Patrick Nana-Sinkam; Marileila Varella-Garcia; Mark W Geraci
Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines.
Molecular cancer research : MCR 2007;5(3):295-308.
2007: Rafal Dziadziuszko; B Holm; B G Skov; Kell Osterlind; M V Sellers; Wilbur A Franklin; Paul A Bunn; Marileila Varella-Garcia; Fred R Hirsch
Epidermal growth factor receptor gene copy number and protein level are not associated with outcome of non-small-cell lung cancer patients treated with chemotherapy.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(3):447-52.
2007: Rafal Dziadziuszko; Anna Siemiatkowska; Janusz Limon; Witold Rzyman; Jacek Jassem; Paul A Bunn; Marileila Varella-Garcia; Fred R Hirsch
Unusual chemosensitivity of advanced bronchioalveolar carcinoma after gefitinib response and progression: a case report.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2007;2(1):91-2.
2006: Barbara Helfrich; David Raben; Marileila Varella-Garcia; Dan Gustafson; Daniel C Chan; Lynne Bemis; Chris Coldren; Anna E Barón; Chan Zeng; Wilbur A Franklin; Fred R Hirsch; Adi F Gazdar; John D Minna; Paul A Bunn
Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(23):7117-25.
2006: Fred R Hirsch; Marileila Varella-Garcia; Paul A Bunn; Wilbur A Franklin; Rafal Dziadziuszko; Nick Thatcher; ALEX CHANG; Purvish Parikh; Jose R Pereira; tudor ciuleanu; Joachim von Pawel; Claire Watkins; Angela Flannery; Gillian Ellison; Emma Donald; Lucy Knight; Dinah Parums; Nick Botwood; Brian Holloway
Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(31):5034-42.
2006: Marileila Varella-Garcia; Lin Chen; Xiaolin Zheng; Linda Yu; Darlene Dixon
Karyotypic characteristics of human uterine leiomyoma and myometrial cell lines following telomerase induction.
Cancer genetics and cytogenetics 2006;170(1):71-5.
2006: Christine H Chung; Kim Ely; Loris McGavran; Marileila Varella-Garcia; Joel Parker; Natalie Parker; Carolyn Jarrett; Jesse Carter; Barbara A Murphy; James L Netterville; Brian B Burkey; Robert Sinard; Anthony J Cmelak; Shawn Levy; Wendell G Yarbrough; Robbert J C Slebos; Fred R Hirsch
Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(25):4170-6.
2006: Britta M Jacobsen; Joshua Chuck Harrell; Paul Jedlicka; Virginia F Borges; Marileila Varella-Garcia; Kathryn B Horwitz
Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium.
Cancer research 2006;66(16):8274-9.
2006: Brian L Rothschild; Ann H Shim; Amanda Gatesman Ammer; Laura C Kelley; Kimberly B Irby; Julie A Head; Lin Chen; Marileila Varella-Garcia; Peter G Sacks; Barbara Frederick; David Raben; Scott A Weed
Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification.
Cancer research 2006;66(16):8017-25.
2006: Rafal Dziadziuszko; Fred R Hirsch; Marileila Varella-Garcia; Paul A Bunn
Selecting lung cancer patients for treatment with epidermal growth factor receptor tyrosine kinase inhibitors by immunohistochemistry and fluorescence in situ hybridization--why, when, and how?
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4409s-4415s.
2006: Federico Cappuzzo; Luca Toschi; Giovanni Tallini; Giovanni Luca Ceresoli; Irene Domenichini; Stefania Bartolini; Giovanna Finocchiaro; Elisabetta Magrini; Giulio Metro; Alessandra Cancellieri; Rocco Trisolini; Lucio Crino; Paul A Bunn; A Santoro; Wilbur A Franklin; Marileila Varella-Garcia; Fred R Hirsch
Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(7):1120-7.
2006: Paul A Bunn; Rafal Dziadziuszko; Marileila Varella-Garcia; Wilbur A Franklin; Samir E Witta; Karen Kelly; Fred R Hirsch
Biological markers for non-small cell lung cancer patient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(12):3652-6.
2006: Federico Cappuzzo; Lynne Bemis; Marileila Varella-Garcia
HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer.
The New England journal of medicine 2006;354(24):2619-21.
2006: Rafal Dziadziuszko; Samir E Witta; Federico Cappuzzo; Seongjin Park; Koji Tanaka; Peter V Danenberg; Anna E Barón; Lucio Crino; Wilbur A Franklin; Paul A Bunn; Marileila Varella-Garcia; Kathleen D Danenberg; Fred R Hirsch
Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(10):3078-84.
2006: German G Gomez; Marileila Varella-Garcia; Carol A Kruse
Isolation of immunoresistant human glioma cell clones after selection with alloreactive cytotoxic T lymphocytes: cytogenetic and molecular cytogenetic characterization.
Cancer genetics and cytogenetics 2006;165(2):121-34.
2006: Marileila Varella-Garcia
Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay.
Diagnostic pathology 2006;1():19.
2006: Tania M Vulcani-Freitas; Vera Lúcia Gil da Silva Lopes; Marileila Varella-Garcia; Andréa T Maciel-Guerra
Infertility and marker chromosomes: application of molecular cytogenetic techniques in a case of inv dup(15).
Journal of applied genetics 2006;47(1):89-91.
2005: Federico Cappuzzo; Luca Toschi; Irene Domenichini; Stefania Bartolini; Giovanni Luca Ceresoli; E Rossi; Vienna Ludovini; Alessandra Cancellieri; Elisabetta Magrini; Lynne Bemis; Wilbur A Franklin; Lucio Crino; Paul A Bunn; Fred R Hirsch; Marileila Varella-Garcia
HER3 genomic gain and sensitivity to gefitinib in advanced non-small-cell lung cancer patients.
British journal of cancer 2005;93(12):1334-40.
2005: Fred R Hirsch; Marileila Varella-Garcia; Jason McCoy; Howard L West; Ana Carolina Xavier; Paul H Gumerlock; Paul A Bunn; Wilbur A Franklin; John Crowley; David R Gandara
Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(28):6838-45.
2005: Federico Cappuzzo; Marileila Varella-Garcia; Hisayuki Shigematsu; Irene Domenichini; Stefania Bartolini; Giovanni Luca Ceresoli; Elisa Rossi; Vienna Ludovini; Vanesa Gregorc; Luca Toschi; Wilbur A Franklin; Lucio Crino; Adi F Gazdar; Paul A Bunn; Fred R Hirsch
Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(22):5007-18.
2005: Federico Cappuzzo; Fred R Hirsch; Elisa Rossi; Stefania Bartolini; Giovanni Luca Ceresoli; Lynne Bemis; Jerry Haney; Samir E Witta; Kathleen D Danenberg; Irene Domenichini; Vienna Ludovini; Elisabetta Magrini; Vanesa Gregorc; Claudio Doglioni; Angelo Sidoni; Maurizio Tonato; Wilbur A Franklin; Lucio Crino; Paul A Bunn; Marileila Varella-Garcia
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer.
Journal of the National Cancer Institute 2005;97(9):643-55.
2005: Bette K Kleinschmidt-DeMasters; Kevin O Lillehei; Marileila Varella-Garcia
Glioblastomas in the older old.
Archives of pathology & laboratory medicine 2005;129(5):624-31.
2005: Victor Prima; Lia Gore; Aimee Caires; T Boomer; M Yoshinari; M Imaizumi; Marileila Varella-Garcia; Stephen P Hunger
Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia.
Leukemia 2005;19(5):806-13.
2005: Kelly J Reichenberger; Ricardo D Coletta; Aline P Schulte; Marileila Varella-Garcia; Heide L Ford
Gene amplification is a mechanism of Six1 overexpression in breast cancer.
Cancer research 2005;65(7):2668-75.
2005: Patrapim Sunpaweravong; Somkiat Sunpaweravong; Puttisak Puttawibul; Winyou Mitarnun; Chan Zeng; Anna E Barón; Wilbur Franklin; Sherif Said; Marileila Varella-Garcia
Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma.
Journal of cancer research and clinical oncology 2005;131(2):111-9.
2004: Ali Ziada; Albaha Barqawi; L Michael Glode; Marileila Varella-Garcia; Frances Crighton; Susan Majeski; Mark Rosenblum; Madeleine Kane; Lin Chen; E David Crawford
The use of trastuzumab in the treatment of hormone refractory prostate cancer; phase II trial.
The Prostate 2004;60(4):332-7.
2004: Marileila Varella-Garcia; John Kittelson; Aline P Schulte; Kieu O Vu; Holly J Wolf; Chan Zeng; Fred R Hirsch; Tim E Byers; Tim Kennedy; York E Miller; Robert L Keith; Wilbur A Franklin
Multi-target interphase fluorescence in situ hybridization assay increases sensitivity of sputum cytology as a predictor of lung cancer.
Cancer detection and prevention 2004;28(4):244-51.
2004: Marileila Varella-Garcia; Bulent Akduman; Patrapim Sunpaweravong; Michael V Di Maria; E David Crawford
The UroVysion fluorescence in situ hybridization assay is an effective tool for monitoring recurrence of bladder cancer.
Urologic oncology 2004;22(1):16-9.
2003: Adrie van Bokhoven; Aimee Caires; Michael Di Maria; Aline Passarini Schulte; M Scott Lucia; Steven K Nordeen; Gary J Miller; Marileila Varella-Garcia
Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines.
The Prostate 2003;57(3):226-44.
2003: Adrie van Bokhoven; Marileila Varella-Garcia; Christopher Korch; Widya U Johannes; E Erin Smith; Heidi L Miller; Steven K Nordeen; Gary J Miller; M Scott Lucia
Molecular characterization of human prostate carcinoma cell lines.
The Prostate 2003;57(3):205-25.
2003: Feng X Li; Jing W Zhu; Jeffery S Tessem; Joshua Beilke; Marileila Varella-Garcia; Jan Jensen; Christopher J Hogan; James DeGregori
The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12935-40.
2003: Fred R Hirsch; Marileila Varella-Garcia; Paul A Bunn; Michael V Di Maria; Robert Veve; Roy M Bremmes; Anna E Barón; Chan Zeng; Wilbur A Franklin
Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(20):3798-807.
2003: Fred R Hirsch; Giorgio V Scagliotti; Corey J Langer; Marileila Varella-Garcia; Wilbur A Franklin
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
Lung cancer (Amsterdam, Netherlands) 2003;41 Suppl 1():S29-42.
2003: Benjamin T Suratt; Marileila Varella-Garcia; Kevin K Brown; Lin Chen; Carlyne D Cool; Amanda E Serls; Elizabeth J Shpall; G Scott Worthen
Human pulmonary chimerism after hematopoietic stem cell transplantation.
American journal of respiratory and critical care medicine 2003;168(3):318-22.
2003: Maura Santos Romeo; Irina A Sokolova; Larry E Morrison; Chan Zeng; Anna E Barón; Fred R Hirsch; York E Miller; Wilbur A Franklin; Marileila Varella-Garcia
Chromosomal abnormalities in non-small cell lung carcinomas and in bronchial epithelia of high-risk smokers detected by multi-target interphase fluorescence in situ hybridization.
The Journal of molecular diagnostics : JMD 2003;5(2):103-12.
2003: Cristina Benitez Vendrame-Goloni; Marileila Varella-Garcia; Andréa Borduchi Carvalho-Salles; Milton Artur Ruiz; Otávio Ricci Júnior; Agnes Cristina Fett-Conte
Translocation (11;19)(q23;p13.3) associated with a novel t(5;16) (q13;q22) in a patient with acute myelocytic leukemia.
Cancer genetics and cytogenetics 2003;141(1):71-4.
2003: Marileila Varella-Garcia
Molecular cytogenetics in solid tumors: laboratorial tool for diagnosis, prognosis, and therapy.
The oncologist 2003;8(1):45-58.
2002: Ana Elizabete Silva; Sheila Adami Vayego-Lourenco; Agnes Cristina Fett-Conte; Eny Maria Goloni-Bertollo; Marileila Varella-Garcia
Tetrasomy 15q11-q13 identified by fluorescence in situ hybridization in a patient with autistic disorder.
Arquivos de neuro-psiquiatria 2002;60(2-A):290-4.
2002: Fred R Hirsch; Marileila Varella-Garcia; Wilbur A Franklin; Robert Veve; L Chen; Barbara Helfrich; Chan Zeng; Anna Baron; Paul A Bunn
Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas.
British journal of cancer 2002;86(9):1449-56.
2002: Fred R Hirsch; Barbara Helfrich; Wilbur A Franklin; Marileila Varella-Garcia; Daniel C Chan; Paul A Bunn
Preclinical studies of gemcitabine and trastuzumab in breast and lung cancer cell lines.
Clinical breast cancer 2002;3 Suppl 1():12-6.
2002: MarcosRobertoHigino Estécio; Agnes Cristina Fett-Conte; Marileila Varella-Garcia; Cintia Fridman; Ana Elizabete Silva
Molecular and cytogenetic analyses on Brazilian youths with pervasive developmental disorders.
Journal of autism and developmental disorders 2002;32(1):35-41.
2002: Fred R Hirsch; Wilbur A Franklin; Robert Veve; Marileila Varella-Garcia; Paul A Bunn
HER2/neu expression in malignant lung tumors.
Seminars in oncology 2002;29(1 Suppl 4):51-8.
2002: Harry A Drabkin; C Parsy; K Ferguson; françois guilhot; Laurence Lacotte; L Roy; C Zeng; A Baron; Stephen P Hunger; Marileila Varella-Garcia; Robert M Gemmill; Françoise Brizard; André Brizard; Joelle Roche
Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia.
Leukemia 2002;16(2):186-95.
2001: Paul A Bunn; Barbara Helfrich; A F Soriano; Wilbur A Franklin; Marileila Varella-Garcia; Fred R Hirsch; Anna Baron; Chan Zeng; Daniel C Chan
Expression of Her-2/neu in human lung cancer cell lines by immunohistochemistry and fluorescence in situ hybridization and its relationship to in vitro cytotoxicity by trastuzumab and chemotherapeutic agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(10):3239-50.
2001: Adrie van Bokhoven; Marileila Varella-Garcia; Christopher Korch; Gary J Miller
TSU-Pr1 and JCA-1 cells are derivatives of T24 bladder carcinoma cells and are not of prostatic origin.
Cancer research 2001;61(17):6340-4.
2001: Marileila Varella-Garcia; Christopher J Hogan; Lorrie F Odom; J L Murata-Collins; H Ai; L Chen; Kathleen E Richkind; G Paskulin; M Andreeff; André Brizard; Loris McGavran; Robert M Gemmill; R Berger; Harry A Drabkin
Minimal residual disease (MRD) in remission t(8;21) AML and in vivo differentiation detected by FISH and CD34+ cell sorting.
Leukemia 2001;15(9):1408-14.
2001: Marileila Varella-Garcia; T Boomer; G J Miller
Karyotypic similarity identified by multiplex-FISH relates four prostate adenocarcinoma cell lines: PC-3, PPC-1, ALVA-31, and ALVA-41.
Genes, chromosomes & cancer 2001;31(4):303-15.
2001: M Berezuk; J West; Marileila Varella-Garcia; Wilbur A Franklin
Adjusting interphase FISH results in epithelial tissue sections to whole cell complement.
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 2001;23(2):93-100.
2001: Adrie van Bokhoven; Marileila Varella-Garcia; Christopher Korch; D Hessels; Gary J Miller
Widely used prostate carcinoma cell lines share common origins.
The Prostate 2001;47(1):36-51.
2001: T Boomer; Marileila Varella-Garcia; Loris McGavran; Lynne Meltesen; A S Olsen; Stephen P Hunger
Detection of E2A translocations in leukemias via fluorescence in situ hybridization.
Leukemia 2001;15(1):95-102.
2000: Kathleen E Richkind; Robert Hromas; C Lytle; D Crenshaw; J Velasco; Synthia Roherty; J Srinivasiah; Marileila Varella-Garcia
Identification of two new translocations that disrupt the AML1 gene.
Cancer genetics and cytogenetics 2000;122(2):141-3.
2000: Robert Hromas; R Shopnick; H G Jumean; C Bowers; Marileila Varella-Garcia; Kathleen E Richkind
A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations.
Blood 2000;95(12):4011-3.
2000: WS Stillman; Marileila Varella-Garcia; Richard D Irons
The benzene metabolite, hydroquinone, selectively induces 5q31- and -7 in human CD34+CD19- bone marrow cells.
Experimental hematology 2000;28(2):169-76.
2000: M Sugita; N Tanaka; S Davidson; S Sekiya; Marileila Varella-Garcia; J West; Harry A Drabkin; Robert M Gemmill
Molecular definition of a small amplification domain within 3q26 in tumors of cervix, ovary, and lung.
Cancer genetics and cytogenetics 2000;117(1):9-18.
1999: WS Stillman; Marileila Varella-Garcia; Richard D Irons
The benzene metabolites hydroquinone and catechol act in synergy to induce dose-dependent hypoploidy and -5q31 in a human cell line.
Leukemia & lymphoma 1999;35(3-4):269-81.
1999: Marileila Varella-Garcia; Françoise Brizard; Joelle Roche; Georges Flandrin; Harry A Drabkin; André Brizard
Aml1/ETO and Pml/RARA rearrangements in a case of AML-M2 acute myeloblastic leukemia with t(15;17).
Leukemia & lymphoma 1999;33(3-4):403-6.
1998: Marileila Varella-Garcia; Robert M Gemmill; S H Rabenhorst; A Lotto; Harry A Drabkin; P A Archer; Wilbur A Franklin
Chromosomal duplication accompanies allelic loss in non-small cell lung carcinoma.
Cancer research 1998;58(20):4701-7.
1998: Carol A Kruse; Marileila Varella-Garcia; Bette K Kleinschmidt-DeMasters; Geoffrey C Owens; E B Spector; Habib Fakhrai; E Savelieva; BC Liang
Receptor expression, cytogenetic, and molecular analysis of six continuous human glioma cell lines.
In vitro cellular & developmental biology. Animal 1998;34(6):455-62.
1998: A Bakir; Ferruh Gezen; O Yildiz; A Ayhan; Serdar Kahraman; C A Kruse; Marileila Varella-Garcia; F Yildiz; A Kubar
Establishment and characterization of a human glioblastoma multiforme cell line.
Cancer genetics and cytogenetics 1998;103(1):46-51.
1998: G A Paskulin; G Philips; R Morgan; A Sandberg; Kathleen E Richkind; C Borovik; Loris McGavran; N Rabinovich; J Dietz-Band; Paul F Erickson; Harry A Drabkin; Marileila Varella-Garcia
Pre-clinical evaluation of probes to detect t(8;21) AML minimal residual disease by fluorescence in situ hybridization.
Genes, chromosomes & cancer 1998;21(2):144-51.
1997: Luciane Cavalli; Marileila Varella-Garcia; BC Liang
Diminished tumorigenic phenotype after depletion of mitochondrial DNA.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(11):1189-98.
1997: WS Stillman; Marileila Varella-Garcia; JJ Gruntmeir; Richard D Irons
The benzene metabolite, hydroquinone, induces dose-dependent hypoploidy in a human cell line.
Leukemia 1997;11(9):1540-5.
1997: S Todd; Wilbur A Franklin; Marileila Varella-Garcia; Tim Kennedy; C E Hilliker; L Hahner; M Anderson; Jonathan S Wiest; Harry A Drabkin; Robert M Gemmill
Homozygous deletions of human chromosome 3p in lung tumors.
Cancer research 1997;57(7):1344-52.
1997: Jonathan S Wiest; Wilbur A Franklin; J T Otstot; K Forbey; Marileila Varella-Garcia; K Rao; Harry A Drabkin; Robert M Gemmill; S Ahrent; David Sidransky; G Saccomanno; J W Fountain; Marshall W Anderson
Identification of a novel region of homozygous deletion on chromosome 9p in squamous cell carcinoma of the lung: the location of a putative tumor suppressor gene.
Cancer research 1997;57(1):1-6.