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Luigi Varesio

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Neuroblastoma

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Daniele Pierobon; Federica Raggi; Luigi Varesio; Tiziana Musso; Francesco Novelli; Fabiola Blengio; Maria Carla Bosco; Paola Cappello; Alessandra Eva; Miriam Filippi; Mirella Giovarelli
Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression.
Fabiola Blengio; Paola Cappello; Alessandra Eva; Mirella Giovarelli; Daniele Pierobon; Federica Raggi; Luigi Varesio; Maria Carla Bosco
The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells.
Maria Carla Bosco; Luigi Varesio
Dendritic cell reprogramming by the hypoxic environment.

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All Publications

2013: Daniele Pierobon; Federica Raggi; Luigi Varesio; Tiziana Musso; Francesco Novelli; Fabiola Blengio; Maria Carla Bosco; Paola Cappello; Alessandra Eva; Miriam Filippi; Mirella Giovarelli
Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression.
European journal of immunology 2013;43(4):949-66.
2013: Fabiola Blengio; Paola Cappello; Alessandra Eva; Mirella Giovarelli; Daniele Pierobon; Federica Raggi; Luigi Varesio; Maria Carla Bosco
The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells.
Immunobiology 2013;218(1):76-89.
2012: Maria Carla Bosco; Luigi Varesio
Dendritic cell reprogramming by the hypoxic environment.
Immunobiology 2012;217(12):1241-9.
2012: Jan J Molenaar; Alexander Schramm; Isabella Bray; Marloes Broekmans; Huib N Caron; Raquel Domingo-Fernández; Ksenija Drabek; Marli E Ebus; Angelika Eggert; Matthias Fischer; Franciska Haneveld; Lukas Heukamp; Kristina Kieckbusch; Ludger Klein-Hitpass; Jan Koster; Sven Lindner; Pieter Mestdagh; Frank Speleman; Annika Sprüssel; Raymond L Stallings; Theresa Thor; Linda J Valentijn; Johan van Nes; Max M van Noesel; Peter G van Sluis; Jo Vandesompele; Luigi Varesio; Rogier Versteeg; Richard Volckmann; Johannes H Schulte
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.
Nature genetics 2012;44(11):1199-206.
2012: Loredana Petecchia; Federica Sabatini; Cesare Usai; Luigi Varesio; Emanuela Caci; Giovanni A Rossi
Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway.
Laboratory investigation; a journal of technical methods and pathology 2012;92(8):1140-8.
2012: Sara Cattelani; Samantha Cialfi; Raffaella Defferrari; Carlo Dominici; Giovanna Ferrari-Amorotti; Valentina Fragliasso; Sara Galavotti; Clara Guerzoni; Alessandro Inserra; Gloria Manzotti; Heather P McDowell; Chiara Menin; Giuseppe Raschellà; Angela Rachele Soliera; Barbara Tanno; Gian Paolo Tonini; Deborah Tweddle; Luigi Varesio; Jenny Vergalli; Pierluigi Altavista; Maria Luisa Belli; Roberta Bertorelle; Bruno Calabretta
The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform.
Neoplasia (New York, N.Y.) 2012;14(7):634-43.
2012: Andrea Cornero; Alessandra Eva; Paolo Fardin; Alexander Schramm; Massimo Acquaviva; Sara Barzaghi; Fabiola Blengio; Maria Carla Bosco; Rogier Versteeg; Luigi Varesio
Design of a multi-signature ensemble classifier predicting neuroblastoma patients' outcome.
BMC bioinformatics 2012;13 Suppl 4():S13.
2011: Roberta Resaz; Daniela Segalerba; Cristina Vanni; Luigi Varesio; Simonetta Astigiano; Ottavia Barbieri; Maria Carla Bosco; Janice Y Chou; Laura Emionite; Carola Eva; Rosa Lavieri; Alessandra Oberto; Annalisa Pezzolo; Maura Puppo; Alessandra Eva
Treatment of newborn G6pc(-/-) mice with bone marrow-derived myelomonocytes induces liver repair.
Journal of hepatology 2011;55(6):1263-71.
2011: Marzia Ognibene; Daniela Segalerba; Maria Rosaria Torrisi; Cristina Vanni; Luigi Varesio; Maria Carla Bosco; Patrizia Mancini; Elisa Merello; Alessandra Eva
The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin.
The Journal of biological chemistry 2011;286(34):29973-83.
2011: Antonio Sica; Giovanni Melillo; Luigi Varesio
Hypoxia: a double-edged sword of immunity.
Journal of molecular medicine (Berlin, Germany) 2011;89(7):657-65.
2011: Marzia Ognibene; Ottavia Barbieri; Cristina Vanni; Luca Mastracci; Simonetta Astigiano; Laura Emionite; Barbara Salani; Manuela Fedele; Roberta Resaz; Claudya Tenca; Franco Fais; Federica Sabatini; Amleto De Santanna; Fiorella Altruda; Luigi Varesio; Emilio Hirsch; Alessandra Eva
High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice.
Journal of molecular medicine (Berlin, Germany) 2011;89(5):493-504.
2011: Maria Carla Bosco; Daniele Pierobon; Fabiola Blengio; Federica Raggi; Cristina Vanni; Marco Gattorno; Alessandra Eva; Francesco Novelli; Paola Cappello; Mirella Giovarelli; Luigi Varesio
Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.
Blood 2011;117(9):2625-39.
2010: Paolo Fardin; Andrea Cornero; Annalisa barla; Sofia Mosci; Massimo Acquaviva; Lorenzo Rosasco; Claudio Gambini; Alessandro Verri; Luigi Varesio
Identification of multiple hypoxia signatures in neuroblastoma cell lines by l1-l2 regularization and data reduction.
Journal of biomedicine & biotechnology 2010;2010():878709.
2010: Paolo Fardin; Annalisa barla; Sofia Mosci; Lorenzo Rosasco; Alessandro Verri; Rogier Versteeg; Huib N Caron; Jan J Molenaar; Ingrid Øra; Alessandra Eva; Maura Puppo; Luigi Varesio
A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients.
Molecular cancer 2010;9():185.
2010: Luigi Varesio; Florinda Battaglia; Federica Raggi; Bernadetta Ledda; Maria Carla Bosco
Macrophage-inflammatory protein-3alpha/CCL-20 is transcriptionally induced by the iron chelator desferrioxamine in human mononuclear phagocytes through nuclear factor (NF)-kappaB.
Molecular immunology 2010;47(4):685-93.
2009: Loredana Petecchia; Federica Sabatini; Luigi Varesio; Anna Camoirano; Cesare Usai; Annalisa Pezzolo; Giovanni A Rossi
Bronchial airway epithelial cell damage following exposure to cigarette smoke includes disassembly of tight junction components mediated by the extracellular signal-regulated kinase 1/2 pathway.
Chest 2009;135(6):1502-12.
2009: Maria Carla Bosco; Silvana Delfino; Francesca Ferlito; Maura Puppo; Andrea Gregorio; Claudio Gambini; Marco Gattorno; Alberto Martini; Luigi Varesio
The hypoxic synovial environment regulates expression of vascular endothelial growth factor and osteopontin in juvenile idiopathic arthritis.
The Journal of rheumatology 2009;36(6):1318-29.
2009: Eleonora Cavarra; Paolo Fardin; Silvia Fineschi; Annamaria Ricciardi; Giovanna De Cunto; Fabio Sallustio; Michele Zorzetto; Maurizio Luisetti; Ulrich Pfeffer; Giuseppe Lungarella; Luigi Varesio
Early response of gene clusters is associated with mouse lung resistance or sensitivity to cigarette smoke.
American journal of physiology. Lung cellular and molecular physiology 2009;296(3):L418-29.
2009: Paolo Fardin; Annalisa barla; Sofia Mosci; Lorenzo Rosasco; Alessandro Verri; Luigi Varesio
The l1-l2 regularization framework unmasks the hypoxia signature hidden in the transcriptome of a set of heterogeneous neuroblastoma cell lines.
BMC genomics 2009;10():474.
2009: Paolo Fardin; Marzia Ognibene; Cristina Vanni; Amleto De Santanna; Luigi Varesio; Alessandra Eva
Induction of epithelial mesenchimal transition and vasculogenesis in the lenses of Dbl oncogene transgenic mice.
PloS one 2009;4(9):e7058.
2008: Angela Rita Elia; Paola Cappello; Maura Puppo; Tiziana Fraone; Cristina Vanni; Alessandra Eva; Tiziana Musso; Francesco Novelli; Luigi Varesio; Mirella Giovarelli
Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile.
Journal of leukocyte biology 2008;84(6):1472-82.
2008: Maura Puppo; Florinda Battaglia; Catherine Ottaviano; Silvana Delfino; Dragana Vukasovic; Luigi Varesio; Maria Carla Bosco
Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.
Molecular cancer therapeutics 2008;7(7):1974-84.
2008: Maria Carla Bosco; Silvana Delfino; Francesca Ferlito; Florinda Battaglia; Maura Puppo; Andrea Gregorio; Claudio Gambini; Marco Gattorno; Alberto Martini; Luigi Varesio
Hypoxic synovial environment and expression of macrophage inflammatory protein 3gamma/CCL20 in juvenile idiopathic arthritis.
Arthritis and rheumatism 2008;58(6):1833-8.
2008: Florinda Battaglia; S Delfino; Elisa Merello; Maura Puppo; Roberto Piva; Luigi Varesio; Maria Carla Bosco
Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.
Journal of leukocyte biology 2008;83(3):648-62.
2008: Annamaria Ricciardi; Angela Rita Elia; Paola Cappello; Maura Puppo; Cristina Vanni; Paolo Fardin; Alessandra Eva; David Munroe; Xiaolin Wu; Mirella Giovarelli; Luigi Varesio
Transcriptome of hypoxic immature dendritic cells: modulation of chemokine/receptor expression.
Molecular cancer research : MCR 2008;6(2):175-85.
2008: Zenghui Mi; Annamaria Rapisarda; Lynn Taylor; Alan Brooks; Mark Creighton-Gutteridge; Giovanni Melillo; Luigi Varesio
Synergystic induction of HIF-1alpha transcriptional activity by hypoxia and lipopolysaccharide in macrophages.
Cell cycle (Georgetown, Tex.) 2008;7(2):232-41.
2008: Maria Carla Bosco; Maura Puppo; Fabiola Blengio; Tiziana Fraone; Paola Cappello; Mirella Giovarelli; Luigi Varesio
Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration.
Immunobiology 2008;213(9-10):733-49.
2007: Cristina Vanni; Patrizia Mancini; Catherine Ottaviano; Marzia Ognibene; Alessia Parodi; Elisa Merello; Chiara Russo; Luigi Varesio; Yi Zheng; Maria Rosaria Torrisi; Alessandra Eva
Galpha13 regulation of proto-Dbl signaling.
Cell cycle (Georgetown, Tex.) 2007;6(16):2058-70.
2007: Maura Puppo; Maria Carla Bosco; Maurizio Federico; sandra Pastorino; Luigi Varesio
Hypoxia inhibits Moloney murine leukemia virus expression in activated macrophages.
Journal of leukocyte biology 2007;81(2):528-38.
2007: B Manzari; J E Kudlow; Paolo Fardin; Elisa Merello; Catherine Ottaviano; Maura Puppo; Alessandra Eva; Luigi Varesio
Induction of macrophage glutamine: fructose-6-phosphate amidotransferase expression by hypoxia and by picolinic acid.
International journal of immunopathology and pharmacology 2007;20(1):47-58.
2007: Paolo Fardin; Stefano Moretti; Barbara Biasotti; Annamaria Ricciardi; Stefano Bonassi; Luigi Varesio
Normalization of low-density microarray using external spike-in controls: analysis of macrophage cell lines expression profile.
BMC genomics 2007;8():17.
2006: Cristina Vanni; Vincenzo Visco; Patrizia Mancini; Alessia Parodi; Catherine Ottaviano; Marzia Ognibene; Andrea D Manazza; SAVERIO FRANCESCO RETTA; Luigi Varesio; Maria Rosaria Torrisi; Alessandra Eva
Inhibition of PI3K induces Rac activation and membrane ruffling in proto-Dbl expressing cells.
Cell cycle (Georgetown, Tex.) 2006;5(22):2657-65.
2006: Maria Carla Bosco; Maura Puppo; Clara Santangelo; Luca Anfosso; Ulrich Pfeffer; Paolo Fardin; Florinda Battaglia; Luigi Varesio
Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1941-55.
2006: Raffaella Melani; Fabio Sallustio; Paolo Fardin; Cristina Vanni; Marzia Ognibene; Catherine Ottaviano; Giovanni Melillo; Luigi Varesio; Alessandra Eva
Growth arrest-inducing genes are activated in Dbl-transformed mouse fibroblasts.
Gene expression 2006;13(3):155-65.
2005: Cristina Vanni; Catherine Ottaviano; Fukun Guo; Maura Puppo; Luigi Varesio; Yi Zheng; Alessandra Eva
Constitutively active Cdc42 mutant confers growth disadvantage in cell transformation.
Cell cycle (Georgetown, Tex.) 2005;4(11):1675-82.
2005: Barbara Salani; Patrizia Damonte; Adriana Zingone; Ottavia Barbieri; Janice Yang Chou; Jenice D'Costa; Suresh K Arya; Alessandra Eva; Luigi Varesio
Newborn liver gene transfer by an HIV-2-based lentiviral vector.
Gene therapy 2005;12(10):803-14.
2004: Maura Puppo; sandra Pastorino; Giovanni Melillo; Annalisa Pezzolo; Luigi Varesio; Maria Carla Bosco
Induction of apoptosis by flavopiridol in human neuroblastoma cells is enhanced under hypoxia and associated with N-myc proto-oncogene down-regulation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8704-19.
2004: Olga Zegarra-Moran; Chiara Folli; Benedetta Manzari; Roberto Ravazzolo; Luigi Varesio; Luis J V Galietta
Double mechanism for apical tryptophan depletion in polarized human bronchial epithelium.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):542-9.
2004: Maria Carla Bosco; Gioia Reffo; Maura Puppo; Luigi Varesio
Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophages.
Cellular immunology 2004;228(1):1-7.
2004: sandra Pastorino; L Carta; Maura Puppo; Giovanni Melillo; Maria Carla Bosco; Luigi Varesio
Picolinic acid- or desferrioxamine-inducible autocrine activation of macrophages engineered to produce IFNgamma: an approach for gene therapy.
Gene therapy 2004;11(6):560-8.
2004: Maria Carla Bosco; Maura Puppo; sandra Pastorino; Zenghui Mi; Giovanni Melillo; Stefano Massazza; Annamaria Rapisarda; Luigi Varesio
Hypoxia selectively inhibits monocyte chemoattractant protein-1 production by macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1681-90.
2003: Anna Mucci; Luigi Varesio; Rachele Neglia; Bruna Colombari; sandra Pastorino; Elisabetta Blasi
Antifungal activity of macrophages engineered to produce IFNgamma: inducibility by picolinic acid.
Medical microbiology and immunology 2003;192(2):71-8.
2003: Chi-Jiunn Pan; Li-Yuan Chen; Brian C Mansfield; Barbara Salani; Luigi Varesio; Janice Yang Chou
The signature motif in human glucose-6-phosphate transporter is essential for microsomal transport of glucose-6-phosphate.
Human genetics 2003;112(4):430-3.
2003: Maria Carla Bosco; Annamaria Rapisarda; Gioia Reffo; Stefano Massazza; sandra Pastorino; Luigi Varesio
Macrophage activating properties of the tryptophan catabolite picolinic acid.
Advances in experimental medicine and biology 2003;527():55-65.
2002: Annamaria Rapisarda; sandra Pastorino; Stefano Massazza; Luigi Varesio; Maria Carla Bosco
Antagonistic effect of picolinic acid and interferon-gamma on macrophage inflammatory protein-1alpha/beta production.
Cellular immunology 2002;220(1):70-80.
2002: Annamaria Rapella; Anna Negrioli; Giovanni Melillo; sandra Pastorino; Luigi Varesio; Maria Carla Bosco
Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma.
International journal of cancer. Journal international du cancer 2002;99(5):658-64.
2001: L Carta; sandra Pastorino; Giovanni Melillo; Maria Carla Bosco; Stefano Massazza; Luigi Varesio
Engineering of macrophages to produce IFN-gamma in response to hypoxia.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5374-80.
2001: sandra Pastorino; Stefano Massazza; Michele Cilli; Luigi Varesio; Maria Carla Bosco
Generation of high-titer retroviral vector-producing macrophages as vehicles for in vivo gene transfer.
Gene therapy 2001;8(6):431-41.
2001: C Dazzi; G Candiano; Stefano Massazza; A Ponzetto; Luigi Varesio
New high-performance liquid chromatographic method for the detection of picolinic acid in biological fluids.
Journal of chromatography. B, Biomedical sciences and applications 2001;751(1):61-8.
2001: Leila Romio; Luigi Varesio
Regulation of taurine transport in murine macrophages.
Amino acids 2001;21(2):151-60.
2000: Maria Carla Bosco; Annamaria Rapisarda; Stefano Massazza; Giovanni Melillo; H Young; Luigi Varesio
The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1 alpha and -1 beta in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3283-91.
1999: Giovanni Melillo; Edward A Sausville; K Cloud; Tyler Lahusen; Luigi Varesio; Adrian M Senderowicz
Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes.
Cancer research 1999;59(21):5433-7.
1998: Luis J V Galietta; Luca Musante; Leila Romio; U Caruso; AR Fantasia; A Gazzolo; L Romano; Oliviero Sacco; G A Rossi; Luigi Varesio; Olga Zegarra-Moran
An electrogenic amino acid transporter in the apical membrane of cultured human bronchial epithelial cells.
The American journal of physiology 1998;275(5 Pt 1):L917-23.
1997: Maria Carla Bosco; Igor Espinoza-Delgado; T K Rowe; Maria Grazia Malabarba; Dan Longo; Luigi Varesio
Functional role for the myeloid differentiation antigen CD14 in the activation of human monocytes by IL-2.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2922-31.
1997: Giovanni Melillo; Lynn S Taylor; A Brooks; Tiziana Musso; G W Cox; Luigi Varesio
Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine.
The Journal of biological chemistry 1997;272(18):12236-43.
1997: S Grgurevich; Diana Linnekin; Tiziana Musso; X Zhang; WS Modi; Luigi Varesio; Francis W Ruscetti; John R Ortaldo; Daniel W McVicar
The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e.
Growth factors (Chur, Switzerland) 1997;14(2-3):103-15.
1997: Rita Carini; Gabriella Leonarduzzi; S Camandola; Tiziana Musso; Luigi Varesio; P A Baeuerle; Giuseppe Poli
Activation of human immunodeficiency virus long terminal repeat by arachidonic acid.
Free radical biology & medicine 1997;22(1-2):195-9.
1996: G Melillo; Lynn S Taylor; A Brooks; G W Cox; Luigi Varesio
Regulation of inducible nitric oxide synthase expression in IFN-gamma-treated murine macrophages cultured under hypoxic conditions.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2638-44.
1996: G Melillo; M C Bosco; Tiziana Musso; Luigi Varesio
Immunobiology of picolinic acid.
Advances in experimental medicine and biology 1996;398():135-41.
1995: G Melillo; Tiziana Musso; A Sica; Lynn S Taylor; G W Cox; Luigi Varesio
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.
The Journal of experimental medicine 1995;182(6):1683-93.
1995: Tiziana Musso; Raffaele Badolato; Dan Longo; G L Gusella; Luigi Varesio
Leukemia inhibitory factor induces interleukin-8 and monocyte chemotactic and activating factor in human monocytes: differential regulation by interferon-gamma.
Blood 1995;86(5):1961-7.
1995: Maria Carla Bosco; K Pulkki; T K Rowe; A H Zea; Tiziana Musso; Dan Longo; Luigi Varesio; Igor Espinoza-Delgado
IL-4 inhibits IL-2-induced tumoricidal activity and secretory functions of human monocytes. Modulation of IL-2 binding and IL-2 receptor beta gamma chain expression.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1411-9.
1995: Tiziana Musso; JA Johnston; Diana Linnekin; Luigi Varesio; T K Rowe; John O'Shea; Daniel W McVicar
Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7.
The Journal of experimental medicine 1995;181(4):1425-31.
1995: G L Gusella; Tiziana Musso; S E Rottschafer; K Pulkki; Luigi Varesio
Potential requirement of a functional double-stranded RNA-dependent protein kinase (PKR) for the tumoricidal activation of macrophages by lipopolysaccharide or IFN-alpha beta, but not IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(1):345-54.
1995: Igor Espinoza-Delgado; Maria Carla Bosco; Tiziana Musso; G L Gusella; Dan Longo; Luigi Varesio
Interleukin-2 and human monocyte activation.
Journal of leukocyte biology 1995;57(1):13-9.
1994: Tiziana Musso; Luigi Varesio; X Zhang; T K Rowe; Pascual Ferrara; John R Ortaldo; John O'Shea; Daniel W McVicar
IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes.
The Journal of experimental medicine 1994;180(6):2383-8.
1994: Tiziana Musso; Maria Carla Bosco; Dan Longo; Igor Espinoza-Delgado; A Sica; G W Cox; G L Gusella; Guido Forni; Luigi Varesio
LPS-inducible nuclear factor in human monocytes that binds the negative regulatory element of the HIV LTR.
Journal of leukocyte biology 1994;56(1):21-6.
1994: Maria Carla Bosco; Igor Espinoza-Delgado; M Schwabe; S M Russell; Warren J Leonard; Dan Longo; Luigi Varesio
The gamma subunit of the interleukin-2 receptor is expressed in human monocytes and modulated by interleukin-2, interferon gamma, and transforming growth factor beta 1.
Blood 1994;83(12):3462-7.
1994: Igor Espinoza-Delgado; Maria Carla Bosco; Tiziana Musso; K Mood; Francis W Ruscetti; Dan Longo; Luigi Varesio
Inhibitory cytokine circuits involving transforming growth factor-beta, interferon-gamma, and interleukin-2 in human monocyte activation.
Blood 1994;83(11):3332-8.
1994: Maria Carla Bosco; Igor Espinoza-Delgado; M Schwabe; G L Gusella; Dan Longo; K Sugamura; Luigi Varesio
Regulation by interleukin-2 (IL-2) and interferon gamma of IL-2 receptor gamma chain gene expression in human monocytes.
Blood 1994;83(10):2995-3002.
1994: G Melillo; G W Cox; A Biragyn; L A Sheffler; Luigi Varesio
Regulation of nitric-oxide synthase mRNA expression by interferon-gamma and picolinic acid.
The Journal of biological chemistry 1994;269(11):8128-33.
1994: Tiziana Musso; G L Gusella; A Brooks; Dan Longo; Luigi Varesio
Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes.
Blood 1994;83(5):1408-11.
1994: Maria Carla Bosco; G L Gusella; Igor Espinoza-Delgado; Dan Longo; Luigi Varesio
Interferon-gamma upregulates interleukin-8 gene expression in human monocytic cells by a posttranscriptional mechanism.
Blood 1994;83(2):537-42.
1993: G L Gusella; Tiziana Musso; Maria Carla Bosco; Igor Espinoza-Delgado; K Matsushima; Luigi Varesio
IL-2 up-regulates but IFN-gamma suppresses IL-8 expression in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2725-32.
1993: G Melillo; G W Cox; D Radzioch; Luigi Varesio
Picolinic acid, a catabolite of L-tryptophan, is a costimulus for the induction of reactive nitrogen intermediate production in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):4031-40.
1993: Maria Carla Bosco; Tiziana Musso; G L Gusella; Mirella Giovarelli; M Forni; A Soleti; Laura Masuelli; Andrea Modesti; Guido Forni; Luigi Varesio
Selective transformation of host lymphocytes in vivo by retrovirus-producing macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):278-89.
1992: G W Cox; G Melillo; U Chattopadhyay; Dan Mullet; RH Fertel; Luigi Varesio
Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumoricidal activity.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3290-6.
1992: Igor Espinoza-Delgado; Dan Longo; G L Gusella; Luigi Varesio
Regulation of IL-2 receptor subunit genes in human monocytes. Differential effects of IL-2 and IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):2961-8.
1992: Tiziana Musso; Igor Espinoza-Delgado; K Pulkki; G L Gusella; Dan Longo; Luigi Varesio
IL-2 induces IL-6 production in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(3):795-800.
1992: E Ayroldi; E Blasi; Luigi Varesio; Robert Wiltrout
Inhibition of proliferation of retrovirus-immortalized macrophages by LPS and IFN-gamma: possible autocrine down-regulation of cell growth by induction of IL1 and TNF.
Biotherapy (Dordrecht, Netherlands) 1992;4(4):267-76.
1992: Luigi Varesio; D Radzioch; B Bottazzi; G L Gusella
Ribosomal RNA metabolism in macrophages.
Current topics in microbiology and immunology 1992;181():209-37.
1991: G W Cox; U Chattopadhyay; Joost J Oppenheim; Luigi Varesio
IL-4 inhibits the costimulatory activity of IL-2 or picolinic acid but not of lipopolysaccharide on IFN-gamma-treated macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3809-14.
1991: A Carbone; G L Gusella; D Radzioch; Luigi Varesio
Human Harvey-ras is biochemically different from Kirsten- or N-ras.
Oncogene 1991;6(5):731-7.
1990: Tiziana Musso; Igor Espinoza-Delgado; K Pulkki; G L Gusella; Dan Longo; Luigi Varesio
Transforming growth factor beta downregulates interleukin-1 (IL-1)-induced IL-6 production by human monocytes.
Blood 1990;76(12):2466-9.
1990: Luigi Varesio; M Clayton; E Blasi; R Ruffman; D Radzioch
Picolinic acid, a catabolite of tryptophan, as the second signal in the activation of IFN-gamma-primed macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(12):4265-71.
1990: G W Cox; B J Mathieson; S L Giardina; Luigi Varesio
Characterization of IL-2 receptor expression and function on murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1719-26.
1990: M T Parodi; Luigi Varesio; Gian Paolo Tonini
The specific inhibitor of protein kinase C, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7), induces morphological change and cell differentiation of human neural crest-derived cell lineages.
FEBS letters 1990;269(1):4-6.
1990: Igor Espinoza-Delgado; Dan Longo; G L Gusella; Luigi Varesio
IL-2 enhances c-fms expression in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(4):1137-43.
1990: JH Pierce; E Di Marco; G W Cox; D Lombardi; M Ruggiero; Luigi Varesio; Ling Mei Wang; Goutam Ghosh Choudhury; A Y Sakaguchi; Pier Paolo Di Fiore
Macrophage-colony-stimulating factor (CSF-1) induces proliferation, chemotaxis, and reversible monocytic differentiation in myeloid progenitor cells transfected with the human c-fms/CSF-1 receptor cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5613-7.
1990: G L Gusella; E Ayroldi; Igor Espinoza-Delgado; Luigi Varesio
Lipopolysaccharide, but not IFN-gamma, down-regulates c-fms mRNA proto-oncogene expression in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3574-80.
1989: G W Cox; B J Mathieson; L Gandino; Elisabetta Blasi; D Radzioch; Luigi Varesio
Heterogeneity of hematopoietic cells immortalized by v-myc/v-raf recombinant retrovirus infection of bone marrow or fetal liver.
Journal of the National Cancer Institute 1989;81(19):1492-6.
1989: Elisabetta Blasi; D Radzioch; L Merletti; Luigi Varesio
Generation of macrophage cell line from fresh bone marrow cells with a myc/raf recombinant retrovirus.
Cancer biochemistry biophysics 1989;10(4):303-17.
1989: C R Faltynek; G L Princler; G L Gusella; Luigi Varesio; D Radzioch
A functional protein kinase C is required for induction of 2-5A synthetase by recombinant interferon-alpha A in Daudi cells.
The Journal of biological chemistry 1989;264(24):14305-11.
1989: John R Ortaldo; Howard A Young; Luigi Varesio
Modulation of CD3- large granular lymphocyte functions by agonist and antagonists of protein kinase C: effects on NK and lymphokine-activated killer activity and production of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):366-71.
1988: S L Giardina; Stephen M Storm; Dan Longo; B J Mathieson; U Rapp; Luigi Varesio
Characterization of a murine monoclonal antibody that detects a C-terminal fragment of the raf oncogene product.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(10):3528-33.
1988: D Radzioch; Luigi Varesio
Protein kinase C inhibitors block the activation of macrophages by IFN-beta but not by IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1259-63.
1988: Elisabetta Blasi; Luigi Varesio; Robert Wiltrout
Tumor formation by a murine macrophage cell line immortalized in vitro by v-raf and v-myc oncogenes.
Cancer immunology, immunotherapy : CII 1988;27(2):109-13.
1988: A Carbone; G L Gusella; D Radzioch; Luigi Varesio
Harvey-ras, but not Kirsten or N-ras, inhibits the induction of C-fos expression.
Annals of the New York Academy of Sciences 1988;551():361-2.
1987: Elisabetta Blasi; D Radzioch; S K Durum; Luigi Varesio
A murine macrophage cell line, immortalized by v-raf and v-myc oncogenes, exhibits normal macrophage functions.
European journal of immunology 1987;17(10):1491-8.
1987: G P Tonini; D Radzioch; A Gronberg; M Clayton; E Blasi; G Benetton; Luigi Varesio
Erythroid differentiation and modulation of c-myc expression induced by antineoplastic drugs in the human leukemic cell line K562.
Cancer research 1987;47(17):4544-7.
1987: D Radzioch; M Clayton; Luigi Varesio
Interferon-alpha, -beta, and -gamma augment the levels of rRNA precursors in peritoneal macrophages but not in macrophage cell lines and fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(3):805-12.
1987: Luigi Varesio; M Clayton; D Radzioch; E Bonvini
Selective inhibition of 28S ribosomal RNA in macrophages activated by interferon-gamma or -beta.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(7):2332-7.