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Eugene Varfolomeev

Research Profile

Chemicals & Drugs

Physiology

Living Beings

Anatomy

Phenomena

Ubiquitination

Concepts & Ideas

Protein Structure, Tertiary

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Publications

TOP 3
Tatiana Goncharov; Anita Izrael-Tomasevic; Donald Kirkpatrick; Kyle Niessen; Eugene Varfolomeev; David Arnott; Maria Cristina de Almagro; Kurt Deshayes; Anna V Fedorova; Domagoj Vucic
OTUB1 modulates c-IAP1 stability to regulate signalling pathways.
Eugene Varfolomeev; Jiping Zha; Kurt Deshayes; Jasmin Dynek; Wayne J Fairbrother; Anna V Fedorova; Jennifer Le Couter; Elham Moradi; Kim Newton; Domagoj Vucic
Characterization of ML-IAP protein stability and physiological role in vivo.
Eugene Varfolomeev; Kerry Zobel; Kurt Deshayes; Tatiana Goncharov; László G Kömüves; Heather Maecker; Domagoj Vucic
Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.

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All Publications

2013: Tatiana Goncharov; Anita Izrael-Tomasevic; Donald Kirkpatrick; Kyle Niessen; Eugene Varfolomeev; David Arnott; Maria Cristina de Almagro; Kurt Deshayes; Anna V Fedorova; Domagoj Vucic
OTUB1 modulates c-IAP1 stability to regulate signalling pathways.
The EMBO journal 2013;32(8):1103-14.
2012: Eugene Varfolomeev; Jiping Zha; Kurt Deshayes; Jasmin Dynek; Wayne J Fairbrother; Anna V Fedorova; Jennifer Le Couter; Elham Moradi; Kim Newton; Domagoj Vucic
Characterization of ML-IAP protein stability and physiological role in vivo.
The Biochemical journal 2012;447(3):427-36.
2012: Eugene Varfolomeev; Kerry Zobel; Kurt Deshayes; Tatiana Goncharov; László G Kömüves; Heather Maecker; Domagoj Vucic
Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.
Science signaling 2012;5(216):ra22.
2011: Erin C Dueber; J Michael Elliott; Kurt Deshayes; Anna V Fedorova; Anthony M Giannetti; Sarah G Hymowitz; Andreas Lingel; Brigitte Maurer; Allyn J Schoeffler; Eugene Varfolomeev; Domagoj Vucic; Heidi J A Wallweber; Ping Wu; Kerry Zobel; Wayne J Fairbrother
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Science (New York, N.Y.) 2011;334(6054):376-80.
2009: John W Blankenship; Eugene Varfolomeev; Tatiana Goncharov; Anna V Fedorova; Donald Kirkpatrick; Anita Izrael-Tomasevic; Lilian Phu; David Arnott; Mariam Aghajan; Kerry Zobel; J. Fernando Bazan; Wayne J Fairbrother; Kurt Deshayes; Domagoj Vucic
Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).
The Biochemical journal 2009;417(1):149-60.
2008: Eugene Varfolomeev; Tatiana Goncharov; Anna V Fedorova; Jasmin Dynek; Kerry Zobel; Kurt Deshayes; Wayne J Fairbrother; Domagoj Vucic
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.
The Journal of biological chemistry 2008;283(36):24295-9.
2008: Eugene Varfolomeev; Domagoj Vucic
(Un)expected roles of c-IAPs in apoptotic and NFkappaB signaling pathways.
Cell cycle (Georgetown, Tex.) 2008;7(11):1511-21.
2007: Eugene Varfolomeev; John W Blankenship; Sarah M Wayson; Anna V Fedorova; Nobuhiko Kayagaki; Parie Garg; Kerry Zobel; Jasmin Dynek; Linda O Elliott; Heidi J A Wallweber; John A Flygare; Wayne J Fairbrother; Kurt Deshayes; Xiaodong Huang; Domagoj Vucic
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.
Cell 2007;131(4):669-81.
2006: P M Eimon; E Kratz; Eugene Varfolomeev; Sarah G Hymowitz; H Stern; J Zha; Avi Ashkenazi
Delineation of the cell-extrinsic apoptosis pathway in the zebrafish.
Cell death and differentiation 2006;13(10):1619-30.
2006: Eugene Varfolomeev; Sarah M Wayson; Xiaodong Huang; Wayne J Fairbrother; Domagoj Vucic
The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.
The Journal of biological chemistry 2006;281(39):29022-9.
2006: Kerry Zobel; Lan Wang; Eugene Varfolomeev; Matthew C Franklin; Linda O Elliott; Heidi J A Wallweber; David C Okawa; John A Flygare; Domagoj Vucic; Wayne J Fairbrother; Kurt Deshayes
Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
ACS chemical biology 2006;1(8):525-33.
2006: Cary D Austin; David A Lawrence; Andrew A Peden; Eugene Varfolomeev; Klara Totpal; Ann M De Mazière; Judith Klumperman; David Arnott; Victoria Pham; Richard H Scheller; Avi Ashkenazi
Death-receptor activation halts clathrin-dependent endocytosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10283-8.
2005: Eugene Varfolomeev; Heather Maecker; Darcie Sharp; David Lawrence; Mark Renz; Domagoj Vucic; Avi Ashkenazi
Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand.
The Journal of biological chemistry 2005;280(49):40599-608.
2005: Heather Maecker; Eugene Varfolomeev; Frank Kischkel; David Lawrence; Heidi LeBlanc; Wyne Lee; Stephen Hurst; Dimitry Danilenko; Jun Li; Ellen H Filvaroff; Becky Yang; Dylan Daniel; Avi Ashkenazi
TWEAK attenuates the transition from innate to adaptive immunity.
Cell 2005;123(5):931-44.
2004: Eugene Varfolomeev; Avi Ashkenazi
Tumor necrosis factor: an apoptosis JuNKie?
Cell 2004;116(4):491-7.
2004: Eugene Varfolomeev; Frank Kischkel; Flavius Martin; Dhaya Seshasayee; Hua Wang; David Lawrence; Christine Olsson; Lucrece Tom; Sharon Erickson; Dorothy French; Peter Schow; Iqbal Grewal; Avi Ashkenazi
APRIL-deficient mice have normal immune system development.
Molecular and cellular biology 2004;24(3):997-1006.
2002: Heidi LeBlanc; David Lawrence; Eugene Varfolomeev; Klara Totpal; John Morlan; Peter Schow; Sherman Fong; Ralph Schwall; Dominick Sinicropi; Avi Ashkenazi
Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.
Nature medicine 2002;8(3):274-81.