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Ajit Varki

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
31
Varki, Nissi
12
Freeze, Hudson
10
Diaz, Sandra
10
Angata, Takashi
10
Borsig, Lubor
10
Gagneux, Pascal
7
Hurtado-Ziola, Nancy
6
Brinkman-Van der Linden, Els
6
Nizet, Victor
5
Altheide, Tasha
4
Hayakawa, Toshiyuki
4
Esko, Jeffrey
4
McEver, Rodger
4
Norgard-Sumnicht, KE
4
Nguyen, Dzung

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Publications

TOP 3
Weiman Shannon; Dahesh Samira; Carlin Aaron F; Varki Ajit; Nizet Victor; Lewis Amanda L
Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact.
Song Dae Jin; Cho Jae Youn; Lee Sang Yeub; Miller Marina; Rosenthal Peter; Soroosh Pejman; Croft Michael; Zhang Mai; Varki Ajit; Broide David H
Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling.
Cohen Miriam; Hurtado-Ziola Nancy; Varki Ajit
ABO blood group glycans modulate sialic acid recognition on erythrocytes.

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All Publications

2009: Weiman Shannon; Dahesh Samira; Carlin Aaron F; Varki Ajit; Nizet Victor; Lewis Amanda L
Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact.
Glycobiology 2009;19(11):1204-13.
2009: Song Dae Jin; Cho Jae Youn; Lee Sang Yeub; Miller Marina; Rosenthal Peter; Soroosh Pejman; Croft Michael; Zhang Mai; Varki Ajit; Broide David H
Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5333-41.
2009: Cohen Miriam; Hurtado-Ziola Nancy; Varki Ajit
ABO blood group glycans modulate sialic acid recognition on erythrocytes.
Blood 2009;114(17):3668-76.
2009: Varki Ajit; Gagneux Pascal
Human-specific evolution of sialic acid targets: explaining the malignant malaria mystery?
Proceedings of the National Academy of Sciences of the United States of America 2009;106(35):14739-40.
2009: Varki Ajit
Ajit Varki: on the origin of maladies. Interviewed by Amy Maxmen.
The Journal of experimental medicine 2009;206(9):1836-7.
2009: Diaz Sandra; Varki Ajit
Metabolic radiolabeling of animal cell glycoconjugates.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2009;Chapter 12():Unit 12.2 12.2.1-55.
2009: Varki Ajit; Freeze Hudson H; Manzi Adriana E
Overview of glycoconjugate analysis.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2009;Chapter 12():Unit 12.1 12.1.1-8.
2009: Lewis Amanda L; Desa Nolan; Hansen Elizabeth E; Knirel Yuriy A; Gordon Jeffrey I; Gagneux Pascal; Nizet Victor; Varki Ajit
Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13552-7.
2009: Varki Ajit
Human uniqueness and the denial of death.
Nature 2009;460(7256):684.
2009: Carlin Aaron F; Chang Yung-Chi; Areschoug Thomas; Lindahl Gunnar; Hurtado-Ziola Nancy; King Charles C; Varki Ajit; Nizet Victor
Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5.
The Journal of experimental medicine 2009;206(8):1691-9.
2009: Varki Ajit
Natural ligands for CD33-related Siglecs?
Glycobiology 2009;19(8):810-2.
2009: Diaz Sandra; Varki Ajit
Metabolic radiolabeling of animal cell glycoconjugates.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2009;Chapter 17():Unit17.4.
2009: Löfling Jonas C; Paton Adrienne W; Varki Nissi M; Paton James C; Varki Ajit
A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome.
Kidney international 2009;76(2):140-4.
2009: Varki Ajit; Varki Nissi M; Borsig Lubor
Molecular basis of metastasis.
The New England journal of medicine 2009;360(16):1678-9; author reply 1679-80.
2009: Carlin Aaron F; Uchiyama Satoshi; Chang Yung-Chi; Lewis Amanda L; Nizet Victor; Varki Ajit
Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response.
Blood 2009;113(14):3333-6.
2009: Song Dae Jin; Cho Jae Youn; Miller Marina; Strangman Wendy; Zhang Mai; Varki Ajit; Broide David H
Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model.
Clinical immunology (Orlando, Fla.) 2009;131(1):157-69.
2009: Varki Ajit
Multiple changes in sialic acid biology during human evolution.
Glycoconjugate journal 2009;26(3):231-45.
2009: Banda Kalyan; Kang Gagandeep; Varki Ajit
'Sialidase sensitivity' of rotaviruses revisited.
Nature chemical biology 2009;5(2):71-2.
2009: Cariappa Annaiah; Takematsu Hiromu; Liu Haoyuan; Diaz Sandra; Haider Khaleda; Boboila Cristian; Kalloo Geetika; Connole Michelle; Shi Hai Ning; Varki Nissi; Varki Ajit; Pillai Shiv
B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase.
The Journal of experimental medicine 2009;206(1):125-38.
2009: Winn Virginia D; Gormley Matthew; Paquet Agnes C; Kjaer-Sorensen Kasper; Kramer Anita; Rumer Kristen K; Haimov-Kochman Ronit; Yeh Ru-Fang; Overgaard Michael T; Varki Ajit; Oxvig Claus; Fisher Susan J
Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2.
Endocrinology 2009;150(1):452-62.
2009: Diaz Sandra L; Padler-Karavani Vered; Ghaderi Darius; Hurtado-Ziola Nancy; Yu Hai; Chen Xi; Brinkman-Van der Linden Els C M; Varki Ajit; Varki Nissi M
Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.
PloS one 2009;4(1):e4241.
2008: Hedlund Maria; Padler-Karavani Vered; Varki Nissi M; Varki Ajit
Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18936-41.
2008: Byres Emma; Paton Adrienne W; Paton James C; Löfling Jonas C; Smith David F; Wilce Matthew C J; Talbot Ursula M; Chong Damien C; Yu Hai; Huang Shengshu; Chen Xi; Varki Nissi M; Varki Ajit; Rossjohn Jamie; Beddoe Travis
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin.
Nature 2008;456(7222):648-52.
2008: Varki Ajit; Geschwind Daniel H; Eichler Evan E
Explaining human uniqueness: genome interactions with environment, behaviour and culture.
Nature reviews. Genetics 2008;9(10):749-63.
2008: Padler-Karavani Vered; Yu Hai; Cao Hongzhi; Chokhawala Harshal; Karp Felix; Varki Nissi; Chen Xi; Varki Ajit
Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease.
Glycobiology 2008;18(10):818-30.
2008: Varki Ajit P; Baum Linda G; Bellis Susan L; Cummings Richard D; Esko Jeffrey D; Hart Gerald W; Linhardt Robert J; Lowe John B; McEver Rodger P; Srivastava Arun; Sarkar Rita
Working group report: the roles of glycans in hemostasis, inflammation and vascular biology.
Glycobiology 2008;18(10):747-9.
2008: Chokhawala Harshal A; Huang Shengshu; Lau Kam; Yu Hai; Cheng Jiansong; Thon Vireak; Hurtado-Ziola Nancy; Guerrero Juan A; Varki Ajit; Chen Xi
Combinatorial chemoenzymatic synthesis and high-throughput screening of sialosides.
ACS chemical biology 2008;3(9):567-76.
2008: Varki Ajit
Sialic acids in human health and disease.
Trends in molecular medicine 2008;14(8):351-60.
2008: Hedlund Maria; Ng Elisa; Varki Ajit; Varki Nissi M
alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo.
Cancer research 2008;68(2):388-94.
2007: Lewis Amanda L; Cao Hongzhi; Patel Silpa K; Diaz Sandra; Ryan Wesley; Carlin Aaron F; Thon Vireak; Lewis Warren G; Varki Ajit; Chen Xi; Nizet Victor
NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus.
The Journal of biological chemistry 2007;282(38):27562-71.
2007: Varki Nissi M; Varki Ajit
Diversity in cell surface sialic acid presentations: implications for biology and disease.
Laboratory investigation; a journal of technical methods and pathology 2007;87(9):851-7.
2007: Brinkman-Van der Linden Els C M; Hurtado-Ziola Nancy; Hayakawa Toshiyuki; Wiggleton Lisa; Benirschke Kurt; Varki Ajit; Varki Nissi
Human-specific expression of Siglec-6 in the placenta.
Glycobiology 2007;17(9):922-31.
2007: Varki Ajit
Trousseau's syndrome: multiple definitions and multiple mechanisms.
Blood 2007;110(6):1723-9.
2007: Yu Hai; Chokhawala Harshal A; Varki Ajit; Chen Xi
Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids.
Organic & biomolecular chemistry 2007;5(15):2458-63.
2007: Sakamoto Norihisa; Tsuji Kazuhide; Muul Linda M; Lawler Ann M; Petricoin Emanuel F; Candotti Fabio; Metcalf Julia A; Tavel Jorge A; Lane H Clifford; Urba Walter J; Fox Bernard A; Varki Ajit; Lunney Joan K; Rosenberg Amy S
Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans.
Blood 2007;110(2):501-8.
2007: Hedlund Maria; Tangvoranuntakul Pam; Takematsu Hiromu; Long Jeffrey M; Housley Gary D; Kozutsumi Yasunori; Suzuki Akemi; Wynshaw-Boris Anthony; Ryan Allen F; Gallo Richard L; Varki Nissi; Varki Ajit
N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution.
Molecular and cellular biology 2007;27(12):4340-6.
2007: Zhang Mai; Angata Takashi; Cho Jae Youn; Miller Marina; Broide David H; Varki Ajit
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.
Blood 2007;109(10):4280-7.
2007: Varki Ajit
Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins.
Nature 2007;446(7139):1023-9.
2007: Crocker Paul R; Paulson James C; Varki Ajit
Siglecs and their roles in the immune system.
Nature reviews. Immunology 2007;7(4):255-66.
2007: Varki Ajit
The uncertain future of research chimpanzees.
Science (New York, N.Y.) 2007;315(5818):1493-4.
2007: Carlin Aaron F; Lewis Amanda L; Varki Ajit; Nizet Victor
Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes.
Journal of bacteriology 2007;189(4):1231-7.
2007: Stevenson Jennifer L; Varki Ajit; Borsig Lubor
Heparin attenuates metastasis mainly due to inhibition of P- and L-selectin, but non-anticoagulant heparins can have additional effects.
Thrombosis research 2007;120 Suppl 2():S107-11.
2006: Angata Takashi; Hayakawa Toshiyuki; Yamanaka Masahiro; Varki Ajit; Nakamura Mitsuru
Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):1964-73.
2006: Varki Ajit
Nothing in glycobiology makes sense, except in the light of evolution.
Cell 2006;126(5):841-5.
2006: Altheide Tasha K; Hayakawa Toshiyuki; Mikkelsen Tarjei S; Diaz Sandra; Varki Nissi; Varki Ajit
System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents: Evidence for two modes of rapid evolution.
The Journal of biological chemistry 2006;281(35):25689-702.
2006: Nguyen Dzung H; Ball Edward D; Varki Ajit
Myeloid precursors and acute myeloid leukemia cells express multiple CD33-related Siglecs.
Experimental hematology 2006;34(6):728-35.
2006: Nguyen Dzung H; Hurtado-Ziola Nancy; Gagneux Pascal; Varki Ajit
Loss of Siglec expression on T lymphocytes during human evolution.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7765-70.
2006: Varki Ajit; Holmes Edward; Yamada Tadataka; Agre Peter; Brenner Sydney
Physician-scientists are needed now more than ever.
Nature 2006;440(7085):740.
2006: Lewis Amanda L; Hensler Mary E; Varki Ajit; Nizet Victor
The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters.
The Journal of biological chemistry 2006;281(16):11186-92.
2006: Chen Helen Y; Challa Anil K; Varki Ajit
9-O-acetylation of exogenously added ganglioside GD3. The GD3 molecule induces its own O-acetylation machinery.
The Journal of biological chemistry 2006;281(12):7825-33.
2006: Wahrenbrock Mark G; Varki Ajit
Multiple hepatic receptors cooperate to eliminate secretory mucins aberrantly entering the bloodstream: are circulating cancer mucins the "tip of the iceberg"?
Cancer research 2006;66(4):2433-41.
2006: Läubli Heinz; Stevenson Jennifer L; Varki Ajit; Varki Nissi M; Borsig Lubor
L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest.
Cancer research 2006;66(3):1536-42.
2006: Hayakawa Toshiyuki; Aki Ikuko; Varki Ajit; Satta Yoko; Takahata Naoyuki
Fixation of the human-specific CMP-N-acetylneuraminic acid hydroxylase pseudogene and implications of haplotype diversity for human evolution.
Genetics 2006;172(2):1139-46.
2006: Varki Ajit; Angata Takashi
Siglecs--the major subfamily of I-type lectins.
Glycobiology 2006;16(1):1R-27R.
2005: Varki Ajit; Altheide Tasha K
Comparing the human and chimpanzee genomes: searching for needles in a haystack.
Genome research 2005;15(12):1746-58.
2005: Stevenson Jennifer L; Choi Sharon H; Varki Ajit
Differential metastasis inhibition by clinically relevant levels of heparins--correlation with selectin inhibition, not antithrombotic activity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):7003-11.
2005: Hayakawa Toshiyuki; Angata Takashi; Lewis Amanda L; Mikkelsen Tarjei S; Varki Nissi M; Varki Ajit
A human-specific gene in microglia.
Science (New York, N.Y.) 2005;309(5741):1693.
2005: McConkey Edwin H; Varki Ajit
Genomics. Thoughts on the future of great ape research.
Science (New York, N.Y.) 2005;309(5740):1499-501.
2005: Gagneux Pascal; Moore James J; Varki Ajit
The ethics of research on great apes.
Nature 2005;437(7055):27-9.
2005: Martin Maria J; Rayner Julian C; Gagneux Pascal; Barnwell John W; Varki Ajit
Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12819-24.
2005: Nguyen Dzung H; Tangvoranuntakul Pam; Varki Ajit
Effects of natural human antibodies against a nonhuman sialic acid that metabolically incorporates into activated and malignant immune cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):228-36.
2005: Jessani Nadim; Young Jason A; Diaz Sandra L; Patricelli Matthew P; Varki Ajit; Cravatt Benjamin F
Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling.
Angewandte Chemie (International ed. in English) 2005;44(16):2400-3.
2005: Lewis Amanda L; Altheide Tasha K; Varki Ajit; Arden Karen; Varki Nissi M
Combining parenting and a science career.
Science (New York, N.Y.) 2005;307(5716):1720-1.
2005: Martin Maria J; Muotri Alysson; Gage Fred; Varki Ajit
Human embryonic stem cells express an immunogenic nonhuman sialic acid.
Nature medicine 2005;11(2):228-32.
2005: Bardor Muriel; Nguyen Dzung H; Diaz Sandra; Varki Ajit
Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells.
The Journal of biological chemistry 2005;280(6):4228-37.
2005: Hayakawa Toshiyuki; Altheide Tasha K; Varki Ajit
Genetic basis of human brain evolution: accelerating along the primate speedway.
Developmental cell 2005;8(1):2-4.
2004: Zhang Mai; Varki Ajit
Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis.
Glycobiology 2004;14(11):939-49.
2004: Varki Ajit
How to make an ape brain.
Nature genetics 2004;36(10):1034-6.
2004: Angata Takashi; Margulies Elliott H; Green Eric D; Varki Ajit
Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13251-6.
2004: Lewis Amanda L; Nizet Victor; Varki Ajit
Discovery and characterization of sialic acid O-acetylation in group B Streptococcus.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(30):11123-8.
2004: Olson Maynard V; Varki Ajit
Genomics. The chimpanzee genome--a bittersweet celebration.
Science (New York, N.Y.) 2004;305(5681):191-2.
2004: Sonnenburg Justin L; Altheide Tasha K; Varki Ajit
A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor.
Glycobiology 2004;14(4):339-46.
2004: Taverna Daniela; Moher Heather; Crowley Denise; Borsig Lubor; Varki Ajit; Hynes Richard O
Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(3):763-8.
2003: Varki Ajit
Open access: the JCI has already shown it works.
Nature 2003;426(6965):383.
2003: Gagneux Pascal; Cheriyan Monica; Hurtado-Ziola Nancy; van der Linden Els C M Brinkman; Anderson Dan; McClure Harold; Varki Ajit; Varki Nissi M
Human-specific regulation of alpha 2-6-linked sialic acids.
The Journal of biological chemistry 2003;278(48):48245-50.
2003: Tangvoranuntakul Pam; Gagneux Pascal; Diaz Sandra; Bardor Muriel; Varki Nissi; Varki Ajit; Muchmore Elaine
Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12045-50.
2003: Wahrenbrock Mark; Borsig Lubor; Le Dzung; Varki Nissi; Varki Ajit
Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas.
The Journal of clinical investigation 2003;112(6):853-62.
2003: Brinkman-Van der Linden Els C M; Angata Takashi; Reynolds Shirley A; Powell Leland D; Hedrick Stephen M; Varki Ajit
CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice.
Molecular and cellular biology 2003;23(12):4199-206.
2003: Satake Honoo; Chen Helen Y; Varki Ajit
Genes modulated by expression of GD3 synthase in Chinese hamster ovary cells. Evidence that the Tis21 gene is involved in the induction of GD3 9-O-acetylation.
The Journal of biological chemistry 2003;278(10):7942-8.
2003: Olson Maynard V; Varki Ajit
Sequencing the chimpanzee genome: insights into human evolution and disease.
Nature reviews. Genetics 2003;4(1):20-8.
2003: Martin Laura T; Verhagen Andrea; Varki Ajit
Recombinant influenza C hemagglutinin-esterase as a probe for sialic acid 9-O-acetylation.
Methods in enzymology 2003;363():489-98.
2003: Brinkman-Van der Linden Els C; Varki Ajit
Probing for masked and unmasked siglecs on cell surfaces.
Methods in enzymology 2003;363():113-20.
2002: Chen Helen Y; Varki Ajit
O-acetylation of GD3: an enigmatic modification regulating apoptosis?
The Journal of experimental medicine 2002;196(12):1529-33.
2002: Matsui Neil M; Varki Ajit; Embury Stephen H
Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin.
Blood 2002;100(10):3790-6.
2002: Chou Hsun-Hua; Hayakawa Toshiyuki; Diaz Sandra; Krings Matthias; Indriati Etty; Leakey Meave; Paabo Svante; Satta Yoko; Takahata Naoyuki; Varki Ajit
Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11736-41.
2002: Martin Laura T; Marth Jamey D; Varki Ajit; Varki Nissi M
Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation.
The Journal of biological chemistry 2002;277(36):32930-8.
2002: Ellies Lesley G; Ditto David; Levy Gallia G; Wahrenbrock Mark; Ginsburg David; Varki Ajit; Le Dzung T; Marth Jamey D
Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10042-7.
2002: Wang Lianchun; Brown Jillian R; Varki Ajit; Esko Jeffrey D
Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins.
The Journal of clinical investigation 2002;110(1):127-36.
2002: Onami Thandi M; Lin Meei-Yun; Page Dawne M; Reynolds Shirley A; Katayama Carol D; Marth Jamey D; Irimura Tatsuro; Varki Ajit; Varki Nissi; Hedrick Stephen M
Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins.
Molecular and cellular biology 2002;22(14):5173-81.
2002: Angata Takashi; Kerr Sheena C; Greaves David R; Varki Nissi M; Crocker Paul R; Varki Ajit
Cloning and characterization of human Siglec-11. A recently evolved signaling that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.
The Journal of biological chemistry 2002;277(27):24466-74.
2002: Varki Ajit; Rosenberg Leon E
Emerging opportunities and career paths for the young physician-scientist.
Nature medicine 2002;8(5):437-9.
2002: Sonnenburg Justin L; van Halbeek Herman; Varki Ajit
Characterization of the acid stability of glycosidically linked neuraminic acid: use in detecting de-N-acetyl-gangliosides in human melanoma.
The Journal of biological chemistry 2002;277(20):17502-10.
2002: Enard Wolfgang; Khaitovich Philipp; Klose Joachim; Zöllner Sebastian; Heissig Florian; Giavalisco Patrick; Nieselt-Struwe Kay; Muchmore Elaine; Varki Ajit; Ravid Rivka; Doxiadis Gaby M; Bontrop Ronald E; Pääbo Svante
Intra- and interspecific variation in primate gene expression patterns.
Science (New York, N.Y.) 2002;296(5566):340-3.
2002: Brinkman-Van der Linden Els C M; Sonnenburg Justin L; Varki Ajit
Effects of sialic acid substitutions on recognition by Sambucus nigra agglutinin and Maackia amurensis hemagglutinin.
Analytical biochemistry 2002;303(1):98-104.
2002: Varki Nissi M; Varki Ajit
Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans.
Seminars in thrombosis and hemostasis 2002;28(1):53-66.
2002: Borsig Lubor; Wong Richard; Hynes Richard O; Varki Nissi M; Varki Ajit
Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2193-8.
2002: Angata Takashi; Varki Ajit
Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.
Chemical reviews 2002;102(2):439-69.
2002: Varki Ajit
Six blind men and the elephant--the many faces of heparan sulfate.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):543-5.
2001: Angata T; Hingorani R; Varki N M; Varki A
Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.
The Journal of biological chemistry 2001;276(48):45128-36.
2001: Angata T; Varki N M; Varki A
A second uniquely human mutation affecting sialic acid biology.
The Journal of biological chemistry 2001;276(43):40282-7.
2001: Hayakawa T; Satta Y; Gagneux P; Varki A; Takahata N
Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid hydroxylase gene.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11399-404.
2001: Matsui N M; Borsig L; Rosen S D; Yaghmai M; Varki A; Embury S H
P-selectin mediates the adhesion of sickle erythrocytes to the endothelium.
Blood 2001;98(6):1955-62.
2001: Borsig L; Wong R; Feramisco J; Nadeau D R; Varki N M; Varki A
Pictures in molecular medicine: three-dimensional visualization of intravascular tumor cells in mice.
Trends in molecular medicine 2001;7(8):377.
2001: Bai X; Brown J R; Varki A; Esko J D
Enhanced 3-O-sulfation of galactose in Asn-linked glycans and Maackia amurensis lectin binding in a new Chinese hamster ovary cell line.
Glycobiology 2001;11(8):621-32.
2001: Varki A
N-glycolylneuraminic acid deficiency in humans.
Biochimie 2001;83(7):615-22.
2001: Gagneux P; Amess B; Diaz S; Moore S; Patel T; Dillmann W; Parekh R; Varki A
Proteomic comparison of human and great ape blood plasma reveals conserved glycosylation and differences in thyroid hormone metabolism.
American journal of physical anthropology 2001;115(2):99-109.
2001: Powell L D; Varki A P; Freeze H H
Release of saccharides from glycoconjugates.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 8():Unit 8.15.
2001: Diaz S; Varki A
Metabolic radiolabeling of animal cell glycoconjugates.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 8():Unit 8.13.
2001: Diaz S; Varki A
Metabolic radiolabeling of animal cell glycoconjugates.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Chapter 12():Unit 12.2.
2001: Varki A; Freeze H H; Manzi A E
Overview of glycoconjugate analysis.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Chapter 12():Unit 12.1.
2001: Srikrishna G; Panneerselvam K; Westphal V; Abraham V; Varki A; Freeze H H
Two proteins modulating transendothelial migration of leukocytes recognize novel carboxylated glycans on endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4678-88.
2001: Borsig L; Wong R; Feramisco J; Nadeau D R; Varki N M; Varki A
Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3352-7.
2001: Gagneux P; Varki A
Genetic differences between humans and great apes.
Molecular phylogenetics and evolution 2001;18(1):2-13.
2001: Srikrishna G; Toomre D K; Manzi A; Panneerselvam K; Freeze H H; Varki A; Varki N M
A novel anionic modification of N-glycans on mammalian endothelial cells is recognized by activated neutrophils and modulates acute inflammatory responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):624-32.
2001: Varki A
Loss of N-glycolylneuraminic acid in humans: Mechanisms, consequences, and implications for hominid evolution.
American journal of physical anthropology 2001;Suppl 33():54-69.
2000: Norgard-Sumnicht K; Bai X; Esko J D; Varki A; Manzi A E
Exploring the outcome of genetic modifications of glycosylation in cultured cell lines by concurrent isolation of the major classes of vertebrate glycans.
Glycobiology 2000;10(7):691-700.
2000: Manzi A E; Norgard-Sumnicht K; Argade S; Marth J D; van Halbeek H; Varki A
Exploring the glycan repertoire of genetically modified mice by isolation and profiling of the major glycan classes and nano-NMR analysis of glycan mixtures.
Glycobiology 2000;10(7):669-89.
2000: Angata T; Varki A
Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways.
The Journal of biological chemistry 2000;275(29):22127-35.
2000: Angata T; Varki A
Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.
Glycobiology 2000;10(4):431-8.
2000: Brinkman-Van der Linden E C; Sjoberg E R; Juneja L R; Crocker P R; Varki N; Varki A
Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs.
The Journal of biological chemistry 2000;275(12):8633-40.
2000: Brinkman-Van der Linden E C; Varki A
New aspects of siglec binding specificities, including the significance of fucosylation and of the sialyl-Tn epitope. Sialic acid-binding immunoglobulin superfamily lectins.
The Journal of biological chemistry 2000;275(12):8625-32.
1999: Razi N; Varki A
Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation.
Glycobiology 1999;9(11):1225-34.
1999: Takematsu H; Diaz S; Stoddart A; Zhang Y; Varki A
Lysosomal and cytosolic sialic acid 9-O-acetylesterase activities can Be encoded by one gene via differential usage of a signal peptide-encoding exon at the N terminus.
The Journal of biological chemistry 1999;274(36):25623-31.
1999: Kim Y J; Borsig L; Han H L; Varki N M; Varki A
Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes, and endothelium.
The American journal of pathology 1999;155(2):461-72.
1999: Chammas R; Sonnenburg J L; Watson N E; Tai T; Farquhar M G; Varki N M; Varki A
De-N-acetyl-gangliosides in humans: unusual subcellular distribution of a novel tumor antigen.
Cancer research 1999;59(6):1337-46.
1998: Muchmore E A; Diaz S; Varki A
A structural difference between the cell surfaces of humans and the great apes.
American journal of physical anthropology 1998;107(2):187-98.
1998: Chou H H; Takematsu H; Diaz S; Iber J; Nickerson E; Wright K L; Muchmore E A; Nelson D L; Warren S T; Varki A
A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11751-6.
1998: Kim Y J; Borsig L; Varki N M; Varki A
P-selectin deficiency attenuates tumor growth and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9325-30.
1998: Razi N; Varki A
Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7469-74.
1998: Koenig A; Norgard-Sumnicht K; Linhardt R; Varki A
Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents.
The Journal of clinical investigation 1998;101(4):877-89.
1998: Shi W X; Chammas R; Varki A
Induction of sialic acid 9-O-acetylation by diverse gene products: implications for the expression cloning of sialic acid O-acetyltransferases.
Glycobiology 1998;8(2):199-205.
1997: Varki A
Selectin ligands: will the real ones please stand up?
The Journal of clinical investigation 1997;100(11 Suppl):S31-5.
1997: Srikrishna G; Varki N M; Newell P C; Varki A; Freeze H H
An IgG monoclonal antibody against Dictyostelium discoideum glycoproteins specifically recognizes Fucalpha1,6GlcNAcbeta in the core of N-linked glycans. Localized expression of core-fucosylated glycoconjugates in human tissues.
The Journal of biological chemistry 1997;272(41):25743-52.
1997: Krishna M; Varki A
9-O-Acetylation of sialomucins: a novel marker of murine CD4 T cells that is regulated during maturation and activation.
The Journal of experimental medicine 1997;185(11):1997-2013.
1997: Varki A
Sialic acids as ligands in recognition phenomena.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(4):248-55.
1997: Koenig A; Jain R; Vig R; Norgard-Sumnicht K E; Matta K L; Varki A
Selectin inhibition: synthesis and evaluation of novel sialylated, sulfated and fucosylated oligosaccharides, including the major capping group of GlyCAM-1.
Glycobiology 1997;7(1):79-93.
1997: Varki A
Selectin ligands: will the real ones please stand up?
The Journal of clinical investigation 1997;99(2):158-62.
1996: Hicke B J; Watson S R; Koenig A; Lynott C K; Bargatze R F; Chang Y F; Ringquist S; Moon-McDermott L; Jennings S; Fitzwater T; Han H L; Varki N; Albinana I; Willis M C; Varki A; Parma D
DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice.
The Journal of clinical investigation 1996;98(12):2688-92.
1996: Shi W X; Chammas R; Varki N M; Powell L; Varki A
Sialic acid 9-O-acetylation on murine erythroleukemia cells affects complement activation, binding to I-type lectins, and tissue homing.
The Journal of biological chemistry 1996;271(49):31526-32.
1996: Shi W X; Chammas R; Varki A
Regulation of sialic acid 9-O-acetylation during the growth and differentiation of murine erythroleukemia cells.
The Journal of biological chemistry 1996;271(49):31517-25.
1996: Chammas R; McCaffery J M; Klein A; Ito Y; Saucan L; Palade G; Farquhar M G; Varki A
Uptake and incorporation of an epitope-tagged sialic acid donor into intact rat liver Golgi compartments. Functional localization of sialyltransferase overlaps with beta-galactosyltransferase but not with sialic acid O-acetyltransferase.
Molecular biology of the cell 1996;7(11):1691-707.
1996: Varki A
"Unusual" modifications and variations of vertebrate oligosaccharides: are we missing the flowers for the trees?
Glycobiology 1996;6(7):707-10.
1996: Shi W X; Chammas R; Varki A
Linkage-specific action of endogenous sialic acid O-acetyltransferase in Chinese hamster ovary cells.
The Journal of biological chemistry 1996;271(25):15130-8.
1996: O'Connell D; Koenig A; Jennings S; Hicke B; Han H L; Fitzwater T; Chang Y F; Varki N; Parma D; Varki A
Calcium-dependent oligonucleotide antagonists specific for L-selectin.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5883-7.
1996: Varki A
Does DG42 synthesize hyaluronan or chitin?: A controversy about oligosaccharides in vertebrate development.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4523-5.
1995: Norgard-Sumnicht K E; Roux L; Toomre D K; Manzi A; Freeze H H; Varki A
Unusual anionic N-linked oligosaccharides from bovine lung.
The Journal of biological chemistry 1995;270(46):27634-45.
1995: Hayes B K; Esquivel F; Bennink J R; Yewdell J W; Varki A
Structure of the N-linked oligosaccharides of MHC class I molecules from cells deficient in the antigenic peptide transporter. Implications for the site of peptide association.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3780-7.
1995: Mannori G; Crottet P; Cecconi O; Hanasaki K; Aruffo A; Nelson R M; Varki A; Bevilacqua M P
Differential colon cancer cell adhesion to E-, P-, and L-selectin: role of mucin-type glycoproteins.
Cancer research 1995;55(19):4425-31.
1995: Norgard-Sumnicht K; Varki A
Endothelial heparan sulfate proteoglycans that bind to L-selectin have glucosamine residues with unsubstituted amino groups.
The Journal of biological chemistry 1995;270(20):12012-24.
1995: Hanasaki K; Varki A; Powell L D
CD22-mediated cell adhesion to cytokine-activated human endothelial cells. Positive and negative regulation by alpha 2-6-sialylation of cellular glycoproteins.
The Journal of biological chemistry 1995;270(13):7533-42.
1995: Powell L D; Jain R K; Matta K L; Sabesan S; Varki A
Characterization of sialyloligosaccharide binding by recombinant soluble and native cell-associated CD22. Evidence for a minimal structural recognition motif and the potential importance of multisite binding.
The Journal of biological chemistry 1995;270(13):7523-32.
1995: Sjoberg E R; Chammas R; Ozawa H; Kawashima I; Khoo K H; Morris H R; Dell A; Tai T; Varki A
Expression of de-N-acetyl-gangliosides in human melanoma cells is induced by genistein or nocodazole.
The Journal of biological chemistry 1995;270(7):2921-30.
1994: Powell L D; Paneerselvam K; Vij R; Diaz S; Manzi A; Buist N; Freeze H; Varki A
Carbohydrate-deficient glycoprotein syndrome: not an N-linked oligosaccharide processing defect, but an abnormality in lipid-linked oligosaccharide biosynthesis?
The Journal of clinical investigation 1994;94(5):1901-9.
1994: Manzi A E; Higa H H; Diaz S; Varki A
Intramolecular self-cleavage of polysialic acid.
The Journal of biological chemistry 1994;269(38):23617-24.
1994: Klein A; Krishna M; Varki N M; Varki A
9-O-acetylated sialic acids have widespread but selective expression: analysis using a chimeric dual-function probe derived from influenza C hemagglutinin-esterase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7782-6.
1994: Varki A
Selectin ligands.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7390-7.
1994: Sjoberg E R; Powell L D; Klein A; Varki A
Natural ligands of the B cell adhesion molecule CD22 beta can be masked by 9-O-acetylation of sialic acids.
The Journal of cell biology 1994;126(2):549-62.
1994: Hanasaki K; Varki A; Stamenkovic I; Bevilacqua M P
Cytokine-induced beta-galactoside alpha-2,6-sialyltransferase in human endothelial cells mediates alpha 2,6-sialylation of adhesion molecules and CD22 ligands.
The Journal of biological chemistry 1994;269(14):10637-43.
1994: Powell L D; Varki A
The oligosaccharide binding specificities of CD22 beta, a sialic acid-specific lectin of B cells.
The Journal of biological chemistry 1994;269(14):10628-36.
1994: Varki A
Metabolic radiolabeling of glycoconjugates.
Methods in enzymology 1994;230():16-32.
1993: Rothenberg B E; Hayes B K; Toomre D; Manzi A E; Varki A
Biotinylated diaminopyridine: an approach to tagging oligosaccharides and exploring their biology.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11939-43.
1993: Hayes B K; Varki A
The biosynthesis of oligosaccharides in intact Golgi preparations from rat liver. Analysis of N-linked and O-linked glycans labeled by UDP-[6-3H]N-acetylgalactosamine.
The Journal of biological chemistry 1993;268(22):16170-8.
1993: Hayes B K; Varki A
Biosynthesis of oligosaccharides in intact Golgi preparations from rat liver. Analysis of N-linked glycans labeled by UDP-[6-3H]galactose, CMP-[9-3H]N-acetylneuraminic acid, and [acetyl-3H]acetyl-coenzyme A.
The Journal of biological chemistry 1993;268(22):16155-69.
1993: Hayes B K; Freeze H H; Varki A
Biosynthesis of oligosaccharides in intact Golgi preparations from rat liver. Analysis of N-linked glycans labeled by UDP-[6-3H]N-acetylglucosamine.
The Journal of biological chemistry 1993;268(22):16139-54.
1993: Norgard K E; Moore K L; Diaz S; Stults N L; Ushiyama S; McEver R P; Cummings R D; Varki A
Characterization of a specific ligand for P-selectin on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides.
The Journal of biological chemistry 1993;268(17):12764-74.
1993: Butor C; Higa H H; Varki A
Structural, immunological, and biosynthetic studies of a sialic acid-specific O-acetylesterase from rat liver.
The Journal of biological chemistry 1993;268(14):10207-13.
1993: Butor C; Diaz S; Varki A
High level O-acetylation of sialic acids on N-linked oligosaccharides of rat liver membranes. Differential subcellular distribution of 7- and 9-O-acetyl groups and of enzymes involved in their regulation.
The Journal of biological chemistry 1993;268(14):10197-206.
1993: Sjoberg E R; Varki A
Kinetic and spatial interrelationships between ganglioside glycosyltransferases and O-acetyltransferase(s) in human melanoma cells.
The Journal of biological chemistry 1993;268(14):10185-96.
1993: Powell L D; Sgroi D; Sjoberg E R; Stamenkovic I; Varki A
Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition.
The Journal of biological chemistry 1993;268(10):7019-27.
1993: Sgroi D; Varki A; Braesch-Andersen S; Stamenkovic I
CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin.
The Journal of biological chemistry 1993;268(10):7011-8.
1993: Norgard K E; Han H; Powell L; Kriegler M; Varki A; Varki N M
Enhanced interaction of L-selectin with the high endothelial venule ligand via selectively oxidized sialic acids.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(3):1068-72.
1992: Sjoberg E R; Manzi A E; Khoo K H; Dell A; Varki A
Structural and immunological characterization of O-acetylated GD2. Evidence that GD2 is an acceptor for ganglioside O-acetyltransferase in human melanoma cells.
The Journal of biological chemistry 1992;267(23):16200-11.
1992: Moore K L; Stults N L; Diaz S; Smith D F; Cummings R D; Varki A; McEver R P
Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells.
The Journal of cell biology 1992;118(2):445-56.
1992: Varki A
Selectins and other mammalian sialic acid-binding lectins.
Current opinion in cell biology 1992;4(2):257-66.
1991: Varki A; Hooshmand F; Diaz S; Varki N M; Hedrick S M
Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase.
Cell 1991;65(1):65-74.
1991: Moore K L; Varki A; McEver R P
GMP-140 binds to a glycoprotein receptor on human neutrophils: evidence for a lectin-like interaction.
The Journal of cell biology 1991;112(3):491-9.
1990: Manzi A E; Sjoberg E R; Diaz S; Varki A
Biosynthesis and turnover of O-acetyl and N-acetyl groups in the gangliosides of human melanoma cells.
The Journal of biological chemistry 1990;265(22):13091-103.
1990: Manzi A E; Dell A; Azadi P; Varki A
Studies of naturally occurring modifications of sialic acids by fast-atom bombardment-mass spectrometry. Analysis of positional isomers by periodate cleavage.
The Journal of biological chemistry 1990;265(14):8094-107.
1989: Muchmore E A; Milewski M; Varki A; Diaz S
Biosynthesis of N-glycolyneuraminic acid. The primary site of hydroxylation of N-acetylneuraminic acid is the cytosolic sugar nucleotide pool.
The Journal of biological chemistry 1989;264(34):20216-23.
1989: Higa H H; Manzi A; Varki A
O-acetylation and de-O-acetylation of sialic acids. Purification, characterization, and properties of a glycosylated rat liver esterase specific for 9-O-acetylated sialic acids.
The Journal of biological chemistry 1989;264(32):19435-42.
1989: Diaz S; Higa H H; Hayes B K; Varki A
O-acetylation and de-O-acetylation of sialic acids. 7- and 9-o-acetylation of alpha 2,6-linked sialic acids on endogenous N-linked glycans in rat liver Golgi vesicles.
The Journal of biological chemistry 1989;264(32):19416-26.
1989: Hayes B K; Varki A
O-acetylation and de-O-acetylation of sialic acids. Sialic acid esterases of diverse evolutionary origins have serine active sites and essential arginine residues.
The Journal of biological chemistry 1989;264(32):19443-8.
1989: Higa H H; Butor C; Diaz S; Varki A
O-acetylation and de-O-acetylation of sialic acids. O-acetylation of sialic acids in the rat liver Golgi apparatus involves an acetyl intermediate and essential histidine and lysine residues--a transmembrane reaction?
The Journal of biological chemistry 1989;264(32):19427-34.
1989: Diaz S; Higa H H; Varki A
Glycoprotein sialate 7(9)-O-acetyltransferase from rat liver Golgi vesicles.
Methods in enzymology 1989;179():416-22.
1989: Higa H H; Manzi A; Diaz S; Varki A
Sialate 9-O-acetylesterase from rat liver.
Methods in enzymology 1989;179():409-15.
1988: Sundblad G; Kajiji S; Quaranta V; Freeze H H; Varki A
Sulfated N-linked oligosaccharides in mammalian cells. III. Characterization of a pancreatic carcinoma cell surface glycoprotein with N- and O-sulfate esters on asparagine-linked glycans.
The Journal of biological chemistry 1988;263(18):8897-903.
1988: Sundblad G; Holojda S; Roux L; Varki A; Freeze H H
Sulfated N-linked oligosaccharides in mammalian cells. II. Identification of glycosaminoglycan-like chains attached to complex-type glycans.
The Journal of biological chemistry 1988;263(18):8890-6.
1988: Roux L; Holojda S; Sundblad G; Freeze H H; Varki A
Sulfated N-linked oligosaccharides in mammalian cells. I. Complex-type chains with sialic acids and O-sulfate esters.
The Journal of biological chemistry 1988;263(18):8879-89.
1988: Higa H H; Varki A
Acetyl-coenzyme A:polysialic acid O-acetyltransferase from K1-positive Escherichia coli. The enzyme responsible for the O-acetyl plus phenotype and for O-acetyl form variation.
The Journal of biological chemistry 1988;263(18):8872-8.
1987: Higa H H; Diaz S; Varki A
Biochemical and genetic evidence for distinct membrane-bound and cytosolic sialic acid O-acetyl-esterases: serine-active-site enzymes.
Biochemical and biophysical research communications 1987;144(3):1099-108.

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