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Ajit Varki

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TOP 3
Jonas Löfling; Sangbom Michael Lyi; Colin R Parrish; Ajit Varki
Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acid.
raghavendra kikkeri; Martijn A Langereis; Vered Padler-Karavani; Hongzhi Cao; Xi Chen; Raoul J de Groot; Sandra Diaz; Andrea Verhagen; Hai Yu; Ajit Varki
Quantum dot nanometal surface energy transfer based biosensing of sialic Acid compositions and linkages in biological samples.
Paula C Soto; Celsa A Spina; Maile Y Karris; Douglas D Richman; Ajit Varki
Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells.

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2013: Jonas Löfling; Sangbom Michael Lyi; Colin R Parrish; Ajit Varki
Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acid.
Virology 2013;440(1):89-96.
2013: raghavendra kikkeri; Martijn A Langereis; Vered Padler-Karavani; Hongzhi Cao; Xi Chen; Raoul J de Groot; Sandra Diaz; Andrea Verhagen; Hai Yu; Ajit Varki
Quantum dot nanometal surface energy transfer based biosensing of sialic Acid compositions and linkages in biological samples.
Analytical chemistry 2013;85(8):3864-70.
2013: Paula C Soto; Celsa A Spina; Maile Y Karris; Douglas D Richman; Ajit Varki
Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells.
Journal of molecular medicine (Berlin, Germany) 2013;91(2):261-70.
2013: Vered Padler-Karavani; Adriana H Tremoulet; Jane C Burns; Xi Chen; Hai Yu; Ajit Varki
A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease.
PloS one 2013;8(3):e58443.
2012: Majesta O'Bleness; Veronica B Searles; Pascal Gagneux; Ajit Varki; James M Sikela
Evolution of genetic and genomic features unique to the human lineage.
Nature reviews. Genetics 2012;13(12):853-66.
2012: Leela R L Davies; Jukka Finne; Pascal Gagneux; Ken Kitajima; Maria Pajunen; Oliver M T Pearce; Alexey Pshezhetsky; Chihiro Sato; Victoria Smutova; Mizuki Sumida; Matthew B Tessier; Siavash Assar; Robert Woods; Ajit Varki
Metabolism of vertebrate amino sugars with N-glycolyl groups: resistance of α2-8-linked N-glycolylneuraminic acid to enzymatic cleavage.
The Journal of biological chemistry 2012;287(34):28917-31.
2012: Anne K Bergfeld; Sandra L Diaz; Oliver M T Pearce; Tho Pham; Ajit Varki
Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid.
The Journal of biological chemistry 2012;287(34):28865-81.
2012: Kalyan Banda; Renee Chow; Christopher J Gregg; Nissi M Varki; Ajit Varki
Metabolism of vertebrate amino sugars with N-glycolyl groups: mechanisms underlying gastrointestinal incorporation of the non-human sialic acid xeno-autoantigen N-glycolylneuraminic acid.
The Journal of biological chemistry 2012;287(34):28852-64.
2012: Anne K Bergfeld; Biswa Choudhury; Sandra L Diaz; Jeffrey D Esko; Roger Lawrence; Oliver M T Pearce; David J Vocadlo; Ajit Varki
Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine.
The Journal of biological chemistry 2012;287(34):28898-916.
2012: Matthew S Macauley; Keith A Stubbs; Ajit Varki; Andrew J Bennet; Jefferson Chan; Gideon J Davies; Yuan He; Garrett E Whitworth; Scott A Yuzwa; Wesley F Zandberg; David J Vocadlo
Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidase.
The Journal of biological chemistry 2012;287(34):28882-97.
2012: Xiaoxia Wang; Nissi M Varki; Takashi Angata; Pedro Cruz; Liwen Deng; Eric D Green; Toshiyuki Hayakawa; Nivedita Mitra; Jim Mullikin; Ajit Varki
Evolution of siglec-11 and siglec-16 genes in hominins.
Molecular biology and evolution 2012;29(8):2073-86.
2012: Vered Padler-Karavani; Melitta Schachner; Richard Schwab; David Smith; Xuezheng Song; Andrea Verhagen; Hai Yu; Xi Chen; Jiansong Cheng; Harshal A Chokhawala; Richard D Cummings; Raoul J de Groot; Shengshu Huang; Nancy Hurtado-Ziola; Ralf Kleene; Martijn A Langereis; Yi Lasanajak; Haruo Matsuda; Saddam Muthana; Ajit Varki
Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays.
The Journal of biological chemistry 2012;287(27):22593-608.
2012: Xiaoxia Wang; Andrea Verhagen; Carlotta Balsamo; Kalyan Banda; William Beggs; Jack Bui; David Caramelli; Giorgio Corti; Pedro Cruz; De Bellis Gianluca; Eric D Green; Toshiyuki Hayakawa; Martina Lari; Laura Longo; Nivedita Mitra; James C Mullikin; Victor Nizet; Vered Padler-Karavani; Chris Reid; Ermanno Rizzi; Ismael Secundino; Sarah A Tishkoff; Ajit Varki
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(25):9935-40.
2012: Ajit Varki
Nothing in medicine makes sense, except in the light of evolution.
Journal of molecular medicine (Berlin, Germany) 2012;90(5):481-94.
2012: Ajit Varki; Pascal Gagneux
Multifarious roles of sialic acids in immunity.
Annals of the New York Academy of Sciences 2012;1253():16-36.
2012: Qiaozhen Lu; Vered Padler-Karavani; Ajit Varki; Shiaw-Lin Wu; Hai Yu; Xi Chen; William S Hancock
LC-MS analysis of polyclonal human anti-Neu5Gc xeno-autoantibodies immunoglobulin G Subclass and partial sequence using multistep intravenous immunoglobulin affinity purification and multienzymatic digestion.
Analytical chemistry 2012;84(6):2761-8.
2012: Darius Ghaderi; Nancy Hurtado-Ziola; Mai Zhang; Ajit Varki
Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation.
Biotechnology & genetic engineering reviews 2012;28():147-75.
2011: Darius Ghaderi; Fang Ma; Patrick Secrest; Stevan A Springer; Rachel E Taylor; Ajit Varki; Miriam Cohen; Pascal Gagneux
Sexual selection by female immunity against paternal antigens can fix loss of function alleles.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(43):17743-8.
2011: Bojing Shao; Ajit Varki; Mark G Wahrenbrock; Lijun Xia; Longbiao Yao; Shaun R Coughlin; Tovo David; Rodger P McEver
Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome.
Blood 2011;118(15):4015-23.
2011: Eitan Rubinstein; Ajit Varki; Seema S Aceves; James Chao; Jae Youn Cho; Marina Miller; Alexa Pham; Peter Rosenthal; David H Broide
Siglec-F inhibition reduces esophageal eosinophilia and angiogenesis in a mouse model of eosinophilic esophagitis.
Journal of pediatric gastroenterology and nutrition 2011;53(4):409-16.
2011: Therése Nordström; Anders I Olin; Ajit Varki; Syed R Ali; Elin Movert; Victor Nizet; Thomas Areschoug
Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein.
The Journal of biological chemistry 2011;286(39):33981-91.
2011: Ajit Varki
Since there are PAMPs and DAMPs, there must be SAMPs? Glycan “self-associated molecular patterns” dampen innate immunity, but pathogens can mimic them.
Glycobiology 2011;21(9):1121-4.
2011: Xiaoxia Wang; Noel Weidner; Albert Zlotnik; Dan Anderson; Chanda Bewtra; Jack Bui; Renee Chow; Liwen Deng; Andrew K Godwin; Ajit Varki; Nissi Varki
Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology.
Glycobiology 2011;21(8):1038-48.
2011: Nivedita Mitra; Lana Schaffer; Nissi Varki; Tasha K Altheide; Takashi Angata; Kalyan Banda; Joke Beuten; Teresa Johnson-Pais; Robin J Leach; Ajit Varki
SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.
The Journal of biological chemistry 2011;286(26):23003-11.
2011: Ajit Varki
Evolutionary forces shaping the Golgi glycosylation machinery: why cell surface glycans are universal to living cells.
Cold Spring Harbor perspectives in biology 2011;3(6):.
2011: Sarah Kavaler; Hidetaka Morinaga; Alice Jih; WuQiang Fan; Maria Hedlund; Ajit Varki; Jane J Kim
Pancreatic beta-cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(6):1887-93.
2011: Vered Padler-Karavani; Nancy Hurtado-Ziola; Minya Pu; Hai Yu; Shengshu Huang; Saddam Muthana; Harshal A Chokhawala; Hongzhi Cao; Patrick Secrest; Dinorah Friedmann-Morvinski; Oded Singer; Darius Ghaderi; Inder M Verma; Yu-Tsueng Liu; Karen Messer; Xi Chen; Ajit Varki; Richard Schwab
Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer.
Cancer research 2011;71(9):3352-63.
2011: Vered Padler-Karavani; Ajit Varki
Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk.
Xenotransplantation 2011;18(1):1-5.
2011: Nissi M Varki; Elizabeth Strobert; Edward J Dick; Kurt Benirschke; Ajit Varki
Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology.
Annual review of pathology 2011;6():365-93.
2010: Ajit Varki
Fate of 'retired' research chimps.
Nature 2010;467(7319):1047.
2010: Rachel E Taylor; Christopher J Gregg; Vered Padler-Karavani; Darius Ghaderi; Hai Yu; Shengshu Huang; Ricardo U Sorensen; Xi Chen; Jaime Inostroza; Victor Nizet; Ajit Varki
Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid.
The Journal of experimental medicine 2010;207(8):1637-46.
2010: Miriam Cohen; Ajit Varki
The sialome--far more than the sum of its parts.
Omics : a journal of integrative biology 2010;14(4):455-64.
2010: Darius Ghaderi; Rachel E Taylor; Vered Padler-Karavani; Sandra Diaz; Ajit Varki
Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins.
Nature biotechnology 2010;28(8):863-7.
2010: Kumaran Chandrasekharan; Jung Hae Yoon; Ying Xu; Sarah deVries; Marybeth Camboni; Paul Janssen; Ajit Varki; Paul T Martin
A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy.
Science translational medicine 2010;2(42):42ra54.
2010: Ajit Varki
Introduction of Stuart Kornfeld.
The Journal of clinical investigation 2010;120(7):2635-8.
2010: Oliver M T Pearce; Ajit Varki
Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose.
Carbohydrate research 2010;345(9):1225-9.
2010: Shannon Weiman; Satoshi Uchiyama; Feng-Ying C Lin; Donald Chaffin; Ajit Varki; Victor Nizet; Amanda L Lewis
O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence.
The Biochemical journal 2010;428(2):163-8.
2010: Ajit Varki
Colloquium paper: uniquely human evolution of sialic acid genetics and biology.
Proceedings of the National Academy of Sciences of the United States of America 2010;107 Suppl 2():8939-46.
2010: Paula C Soto; Lance L Stein; Nancy Hurtado-Ziola; Stephen M Hedrick; Ajit Varki
Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(8):4185-95.
2010: Xi Chen; Ajit Varki
Advances in the biology and chemistry of sialic acids.
ACS chemical biology 2010;5(2):163-76.
2010: Jae Youn Cho; Dae Jae Song; Alexa Pham; Peter Rosenthal; Marina Miller; Shanna Dayan; Taylor A Doherty; Ajit Varki; David H Broide
Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13.
Respiratory research 2010;11():154.
2009: Tho Pham; Christopher J Gregg; Felix Karp; Renee Chow; Vered Padler-Karavani; Hongzhi Cao; Xi Chen; Joseph L Witztum; Nissi M Varki; Ajit Varki
Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium.
Blood 2009;114(25):5225-35.
2009: Ajit Varki; Richard D Cummings; Jeffrey D Esko; Hudson H Freeze; Pamela Stanley; Jamey D Marth; Carolyn R Bertozzi; Gerald W Hart; Marilynn E Etzler
Symbol nomenclature for glycan representation.
Proteomics 2009;9(24):5398-9.
2009: Shannon Weiman; Samira Dahesh; Aaron F Carlin; Ajit Varki; Victor Nizet; Amanda L Lewis
Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact.
Glycobiology 2009;19(11):1204-13.
2009: Miriam Cohen; Nancy Hurtado-Ziola; Ajit Varki
ABO blood group glycans modulate sialic acid recognition on erythrocytes.
Blood 2009;114(17):3668-76.
2009: Dae Jin Song; Jae Youn Cho; Sang Yeub Lee; Marina Miller; Peter Rosenthal; pejman Soroosh; Michael Croft; Mai Zhang; Ajit Varki; David H Broide
Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5333-41.
2009: Ajit Varki; Pascal Gagneux
Human-specific evolution of sialic acid targets: explaining the malignant malaria mystery?
Proceedings of the National Academy of Sciences of the United States of America 2009;106(35):14739-40.
2009: Ajit Varki
Ajit Varki: on the origin of maladies. Interviewed by Amy Maxmen.
The Journal of experimental medicine 2009;206(9):1836-7.
2009: Amanda L Lewis; Nolan Desa; Elizabeth E Hansen; Yuriy A Knirel; Jeffrey I Gordon; Pascal Gagneux; Victor Nizet; Ajit Varki
Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13552-7.
2009: Ajit Varki
Human uniqueness and the denial of death.
Nature 2009;460(7256):684.
2009: Aaron F Carlin; Yung-Chi Chang; Thomas Areschoug; Gunnar Lindahl; Nancy Hurtado-Ziola; Charles C King; Ajit Varki; Victor Nizet
Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5.
The Journal of experimental medicine 2009;206(8):1691-9.
2009: Sandra Diaz; Ajit Varki
Metabolic radiolabeling of animal cell glycoconjugates.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2009;Chapter 12():Unit 12.2 12.2.1-55.
2009: Ajit Varki; Hudson H Freeze; Adriana E Manzi
Overview of glycoconjugate analysis.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2009;Chapter 12():Unit 12.1 12.1.1-8.
2009: Ajit Varki
Natural ligands for CD33-related Siglecs?
Glycobiology 2009;19(8):810-2.
2009: Sandra Diaz; Ajit Varki
Metabolic radiolabeling of animal cell glycoconjugates.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2009;Chapter 17():Unit17.4.
2009: Jonas C Löfling; Adrienne W Paton; Nissi M Varki; James C Paton; Ajit Varki
A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome.
Kidney international 2009;76(2):140-4.
2009: Ajit Varki; Nissi M Varki; Lubor Borsig
Molecular basis of metastasis.
The New England journal of medicine 2009;360(16):1678-9; author reply 1679-80.
2009: Aaron F Carlin; Satoshi Uchiyama; Yung-Chi Chang; Amanda L Lewis; Victor Nizet; Ajit Varki
Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response.
Blood 2009;113(14):3333-6.
2009: Dae Jin Song; Jae Youn Cho; Marina Miller; Wendy Strangman; Mai Zhang; Ajit Varki; David H Broide
Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model.
Clinical immunology (Orlando, Fla.) 2009;131(1):157-69.
2009: Ajit Varki
Multiple changes in sialic acid biology during human evolution.
Glycoconjugate journal 2009;26(3):231-45.
2009: Kalyan Banda; Gagandeep Kang; Ajit Varki
'Sialidase sensitivity' of rotaviruses revisited.
Nature chemical biology 2009;5(2):71-2.
2009: Annaiah Cariappa; Hiromu Takematsu; Haoyuan Liu; Sandra Diaz; Khaleda Haider; Cristian Boboila; Geetika Kalloo; Michelle Connole; Hai Ning Shi; Nissi Varki; Ajit Varki; Shiv Pillai
B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase.
The Journal of experimental medicine 2009;206(1):125-38.
2009: Sandra L Diaz; Vered Padler-Karavani; Darius Ghaderi; Nancy Hurtado-Ziola; Hai Yu; Xi Chen; Els C M Brinkman-Van der Linden; Ajit Varki; Nissi M Varki
Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.
PloS one 2009;4(1):e4241.
2009: Virginia D Winn; Matthew Gormley; Agnes C Paquet; Kasper Kjaer-Sorensen; Anita Kramer; Kristen K Rumer; Ronit Haimov-Kochman; Ru-Fang Yeh; Michael T Overgaard; Ajit Varki; Claus Oxvig; Susan J Fisher
Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2.
Endocrinology 2009;150(1):452-62.
2008: Emma Byres; Adrienne W Paton; James C Paton; Jonas C Löfling; David Smith; Matthew C J Wilce; Ursula M Talbot; Damien C Chong; Hai Yu; Shengshu Huang; Xi Chen; Nissi M Varki; Ajit Varki; Jamie Rossjohn; Travis Beddoe
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin.
Nature 2008;456(7222):648-52.
2008: Maria Hedlund; Vered Padler-Karavani; Nissi M Varki; Ajit Varki
Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18936-41.
2008: Ajit Varki; Daniel Geschwind; Evan E Eichler
Explaining human uniqueness: genome interactions with environment, behaviour and culture.
Nature reviews. Genetics 2008;9(10):749-63.
2008: Vered Padler-Karavani; Hai Yu; Hongzhi Cao; Harshal Chokhawala; Felix Karp; Nissi M Varki; Xi Chen; Ajit Varki
Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease.
Glycobiology 2008;18(10):818-30.
2008: Ajit Varki; Linda G Baum; Susan L Bellis; Richard D Cummings; Jeffrey D Esko; Gerald W Hart; Robert J Linhardt; John B Lowe; Rodger P McEver; Arun Srivastava; Rita Sarkar
Working group report: the roles of glycans in hemostasis, inflammation and vascular biology.
Glycobiology 2008;18(10):747-9.
2008: Harshal A Chokhawala; Shengshu Huang; Kam Lau; Hai Yu; Jiansong Cheng; Vireak Thon; Nancy Hurtado-Ziola; Juan A Guerrero; Ajit Varki; Xi Chen
Combinatorial chemoenzymatic synthesis and high-throughput screening of sialosides.
ACS chemical biology 2008;3(9):567-76.
2008: Ajit Varki
Sialic acids in human health and disease.
Trends in molecular medicine 2008;14(8):351-60.
2008: Maria Hedlund; Elisa Ng; Ajit Varki; Nissi M Varki
alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo.
Cancer research 2008;68(2):388-94.
2007: Amanda L Lewis; Hongzhi Cao; Silpa K Patel; Sandra Diaz; Wesley Ryan; Aaron F Carlin; Vireak Thon; Warren G Lewis; Ajit Varki; Xi Chen; Victor Nizet
NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus.
The Journal of biological chemistry 2007;282(38):27562-71.
2007: Ajit Varki
Trousseau's syndrome: multiple definitions and multiple mechanisms.
Blood 2007;110(6):1723-9.
2007: Nissi M Varki; Ajit Varki
Diversity in cell surface sialic acid presentations: implications for biology and disease.
Laboratory investigation; a journal of technical methods and pathology 2007;87(9):851-7.
2007: Els C M Brinkman-Van der Linden; Nancy Hurtado-Ziola; Toshiyuki Hayakawa; Lisa Wiggleton; Kurt Benirschke; Ajit Varki; Nissi M Varki
Human-specific expression of Siglec-6 in the placenta.
Glycobiology 2007;17(9):922-31.
2007: Hai Yu; Harshal A Chokhawala; Ajit Varki; Xi Chen
Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids.
Organic & biomolecular chemistry 2007;5(15):2458-63.
2007: Norihisa Sakamoto; Kazuhide Tsuji; Linda Muul; Ann M Lawler; Emanuel F Petricoin; Fabio Candotti; Julia A Metcalf; Jorge A Tavel; H Clifford Lane; Walter J Urba; Fox Bernard; Ajit Varki; Joan K Lunney; Amy S Rosenberg
Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans.
Blood 2007;110(2):501-8.
2007: Maria Hedlund; Pam Tangvoranuntakul; Hiromu Takematsu; Jeffrey M Long; Gary D Housley; Yasunori Kozutsumi; Akemi Suzuki; Anthony Wynshaw-Boris; Allen F Ryan; Richard L Gallo; Nissi M Varki; Ajit Varki
N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution.
Molecular and cellular biology 2007;27(12):4340-6.
2007: Mai Zhang; Takashi Angata; Jae Youn Cho; Marina Miller; David H Broide; Ajit Varki
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.
Blood 2007;109(10):4280-7.
2007: Ajit Varki
Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins.
Nature 2007;446(7139):1023-9.
2007: Paul R Crocker; James C Paulson; Ajit Varki
Siglecs and their roles in the immune system.
Nature reviews. Immunology 2007;7(4):255-66.
2007: Ajit Varki
The uncertain future of research chimpanzees.
Science (New York, N.Y.) 2007;315(5818):1493-4.
2007: Aaron F Carlin; Amanda L Lewis; Ajit Varki; Victor Nizet
Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes.
Journal of bacteriology 2007;189(4):1231-7.
2007: Jennifer L Stevenson; Ajit Varki; Lubor Borsig
Heparin attenuates metastasis mainly due to inhibition of P- and L-selectin, but non-anticoagulant heparins can have additional effects.
Thrombosis research 2007;120 Suppl 2():S107-11.
2006: Takashi Angata; Toshiyuki Hayakawa; Masahiro Yamanaka; Ajit Varki; Mitsuru Nakamura
Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):1964-73.
2006: Ajit Varki
Nothing in glycobiology makes sense, except in the light of evolution.
Cell 2006;126(5):841-5.
2006: Tasha K Altheide; Toshiyuki Hayakawa; Tarjei S Mikkelsen; Sandra Diaz; Nissi M Varki; Ajit Varki
System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents: Evidence for two modes of rapid evolution.
The Journal of biological chemistry 2006;281(35):25689-702.
2006: Dzung Nguyen; Edward D Ball; Ajit Varki
Myeloid precursors and acute myeloid leukemia cells express multiple CD33-related Siglecs.
Experimental hematology 2006;34(6):728-35.
2006: Dzung Nguyen; Nancy Hurtado-Ziola; Pascal Gagneux; Ajit Varki
Loss of Siglec expression on T lymphocytes during human evolution.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7765-70.
2006: Amanda L Lewis; Mary E Hensler; Ajit Varki; Victor Nizet
The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters.
The Journal of biological chemistry 2006;281(16):11186-92.
2006: Ajit Varki; Edward Holmes; Tadataka Yamada; Peter Agre; Sydney Brenner
Physician-scientists are needed now more than ever.
Nature 2006;440(7085):740.
2006: Helen Y Chen; Anil K Challa; Ajit Varki
9-O-acetylation of exogenously added ganglioside GD3. The GD3 molecule induces its own O-acetylation machinery.
The Journal of biological chemistry 2006;281(12):7825-33.
2006: Mark G Wahrenbrock; Ajit Varki
Multiple hepatic receptors cooperate to eliminate secretory mucins aberrantly entering the bloodstream: are circulating cancer mucins the "tip of the iceberg"?
Cancer research 2006;66(4):2433-41.
2006: Heinz Läubli; Jennifer L Stevenson; Ajit Varki; Nissi M Varki; Lubor Borsig
L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest.
Cancer research 2006;66(3):1536-42.
2006: Toshiyuki Hayakawa; Ikuko Aki; Ajit Varki; Yoko Satta; Naoyuki Takahata
Fixation of the human-specific CMP-N-acetylneuraminic acid hydroxylase pseudogene and implications of haplotype diversity for human evolution.
Genetics 2006;172(2):1139-46.
2006: Ajit Varki; Takashi Angata
Siglecs--the major subfamily of I-type lectins.
Glycobiology 2006;16(1):1R-27R.
2005: Ajit Varki; Tasha K Altheide
Comparing the human and chimpanzee genomes: searching for needles in a haystack.
Genome research 2005;15(12):1746-58.
2005: Jennifer L Stevenson; Sharon H Choi; Ajit Varki
Differential metastasis inhibition by clinically relevant levels of heparins--correlation with selectin inhibition, not antithrombotic activity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):7003-11.
2005: Toshiyuki Hayakawa; Takashi Angata; Amanda L Lewis; Tarjei S Mikkelsen; Nissi M Varki; Ajit Varki
A human-specific gene in microglia.
Science (New York, N.Y.) 2005;309(5741):1693.
2005: Maria J Martin; Julian C Rayner; Pascal Gagneux; John W Barnwell; Ajit Varki
Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12819-24.
2005: Edwin H McConkey; Ajit Varki
Genomics. Thoughts on the future of great ape research.
Science (New York, N.Y.) 2005;309(5740):1499-501.
2005: Pascal Gagneux; James J Moore; Ajit Varki
The ethics of research on great apes.
Nature 2005;437(7055):27-9.
2005: Dzung Nguyen; Pam Tangvoranuntakul; Ajit Varki
Effects of natural human antibodies against a nonhuman sialic acid that metabolically incorporates into activated and malignant immune cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):228-36.
2005: Nadim Jessani; Jason A Young; Sandra L Diaz; Matthew P Patricelli; Ajit Varki; Benjamin F Cravatt
Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling.
Angewandte Chemie (International ed. in English) 2005;44(16):2400-3.
2005: Amanda L Lewis; Tasha K Altheide; Ajit Varki; Karen C Arden; Nissi M Varki
Combining parenting and a science career.
Science (New York, N.Y.) 2005;307(5716):1720-1.
2005: Muriel Bardor; Dzung Nguyen; Sandra Diaz; Ajit Varki
Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells.
The Journal of biological chemistry 2005;280(6):4228-37.
2005: Maria J Martin; Alysson Muotri; Fred Gage; Ajit Varki
Human embryonic stem cells express an immunogenic nonhuman sialic acid.
Nature medicine 2005;11(2):228-32.
2005: Toshiyuki Hayakawa; Tasha K Altheide; Ajit Varki
Genetic basis of human brain evolution: accelerating along the primate speedway.
Developmental cell 2005;8(1):2-4.
2004: Mai Zhang; Ajit Varki
Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis.
Glycobiology 2004;14(11):939-49.
2004: Ajit Varki
How to make an ape brain.
Nature genetics 2004;36(10):1034-6.
2004: Takashi Angata; Elliott H Margulies; Eric Green; Ajit Varki
Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13251-6.
2004: Amanda L Lewis; Victor Nizet; Ajit Varki
Discovery and characterization of sialic acid O-acetylation in group B Streptococcus.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(30):11123-8.
2004: Maynard V Olson; Ajit Varki
Genomics. The chimpanzee genome--a bittersweet celebration.
Science (New York, N.Y.) 2004;305(5681):191-2.
2004: Justin L Sonnenburg; Tasha K Altheide; Ajit Varki
A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor.
Glycobiology 2004;14(4):339-46.
2004: Daniela Taverna; Heather Moher; Denise Crowley; Lubor Borsig; Ajit Varki; Richard O Hynes
Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(3):763-8.
2003: Pascal Gagneux; Monica Cheriyan; Nancy Hurtado-Ziola; Els C M Brinkman van der Linden; Dan Anderson; Harold McClure; Ajit Varki; Nissi M Varki
Human-specific regulation of alpha 2-6-linked sialic acids.
The Journal of biological chemistry 2003;278(48):48245-50.
2003: Ajit Varki
Open access: the JCI has already shown it works.
Nature 2003;426(6965):383.
2003: Pam Tangvoranuntakul; Pascal Gagneux; Sandra Diaz; Muriel Bardor; Nissi M Varki; Ajit Varki; Elaine A Muchmore
Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12045-50.
2003: Mark Wahrenbrock; Lubor Borsig; Dzung Le; Nissi M Varki; Ajit Varki
Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas.
The Journal of clinical investigation 2003;112(6):853-62.
2003: Els C M Brinkman-Van der Linden; Takashi Angata; Shirley A Reynolds; Leland D Powell; Stephen M Hedrick; Ajit Varki
CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice.
Molecular and cellular biology 2003;23(12):4199-206.
2003: Honoo Satake; Helen Y Chen; Ajit Varki
Genes modulated by expression of GD3 synthase in Chinese hamster ovary cells. Evidence that the Tis21 gene is involved in the induction of GD3 9-O-acetylation.
The Journal of biological chemistry 2003;278(10):7942-8.
2003: Laura T Martin; Andrea Verhagen; Ajit Varki
Recombinant influenza C hemagglutinin-esterase as a probe for sialic acid 9-O-acetylation.
Methods in enzymology 2003;363():489-98.
2003: Els C Brinkman-Van der Linden; Ajit Varki
Probing for masked and unmasked siglecs on cell surfaces.
Methods in enzymology 2003;363():113-20.
2003: Maynard V Olson; Ajit Varki
Sequencing the chimpanzee genome: insights into human evolution and disease.
Nature reviews. Genetics 2003;4(1):20-8.
2002: Helen Y Chen; Ajit Varki
O-acetylation of GD3: an enigmatic modification regulating apoptosis?
The Journal of experimental medicine 2002;196(12):1529-33.
2002: Neil M Matsui; Ajit Varki; Stephen Embury
Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin.
Blood 2002;100(10):3790-6.
2002: Laura T Martin; Jamey D Marth; Ajit Varki; Nissi M Varki
Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation.
The Journal of biological chemistry 2002;277(36):32930-8.
2002: Hsun-Hua Chou; Toshiyuki Hayakawa; Sandra Diaz; Matthias Krings; Etty Indriati; Meave Leakey; Svante Paabo; Yoko Satta; Naoyuki Takahata; Ajit Varki
Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11736-41.
2002: Lesley G Ellies; David Ditto; Gallia G Levy; Mark Wahrenbrock; David Ginsburg; Ajit Varki; Dzung T Le; Jamey D Marth
Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10042-7.
2002: Takashi Angata; Sheena C Kerr; David Greaves; Nissi M Varki; Paul R Crocker; Ajit Varki
Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.
The Journal of biological chemistry 2002;277(27):24466-74.
2002: Lianchun Wang; Jillian R Brown; Ajit Varki; Jeffrey D Esko
Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins.
The Journal of clinical investigation 2002;110(1):127-36.
2002: Thandi M Onami; Meei Yun Lin; Dawne M Page; Shirley A Reynolds; Carol D Katayama; Jamey D Marth; Tatsuro Irimura; Ajit Varki; Nissi M Varki; Stephen M Hedrick
Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins.
Molecular and cellular biology 2002;22(14):5173-81.
2002: Justin L Sonnenburg; Herman van Halbeek; Ajit Varki
Characterization of the acid stability of glycosidically linked neuraminic acid: use in detecting de-N-acetyl-gangliosides in human melanoma.
The Journal of biological chemistry 2002;277(20):17502-10.
2002: Ajit Varki; Leon E Rosenberg
Emerging opportunities and career paths for the young physician-scientist.
Nature medicine 2002;8(5):437-9.
2002: Wolfgang Enard; Philipp Khaitovich; Joachim Klose; Sebastian K Zoellner ; Florian Heissig; Patrick Giavalisco; Kay Nieselt-Struwe; Elaine Muchmore; Ajit Varki; Rivka Ravid; Gaby M Doxiadis; Ronald E Bontrop; Svante Pääbo
Intra- and interspecific variation in primate gene expression patterns.
Science (New York, N.Y.) 2002;296(5566):340-3.
2002: Els C M Brinkman-Van der Linden; Justin L Sonnenburg; Ajit Varki
Effects of sialic acid substitutions on recognition by Sambucus nigra agglutinin and Maackia amurensis hemagglutinin.
Analytical biochemistry 2002;303(1):98-104.
2002: Lubor Borsig; Richard Wong; Richard O Hynes; Nissi M Varki; Ajit Varki
Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2193-8.
2002: Nissi M Varki; Ajit Varki
Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans.
Seminars in thrombosis and hemostasis 2002;28(1):53-66.
2002: Takashi Angata; Ajit Varki
Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.
Chemical reviews 2002;102(2):439-69.
2002: Ajit Varki
Six blind men and the elephant--the many faces of heparan sulfate.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):543-5.
2001: Takashi Angata; R Hingorani; Nissi M Varki; Ajit Varki
Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.
The Journal of biological chemistry 2001;276(48):45128-36.
2001: Takashi Angata; Nissi M Varki; Ajit Varki
A second uniquely human mutation affecting sialic acid biology.
The Journal of biological chemistry 2001;276(43):40282-7.
2001: T Hayakawa; Yoko Satta; Pascal Gagneux; Ajit Varki; Naoyuki Takahata
Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid hydroxylase gene.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11399-404.
2001: Neil M Matsui; L Borsig; S D Rosen; M Yaghmai; Ajit Varki; Stephen Embury
P-selectin mediates the adhesion of sickle erythrocytes to the endothelium.
Blood 2001;98(6):1955-62.
2001: Lubor Borsig; R Wong; J Feramisco; D R Nadeau; Nissi M Varki; Ajit Varki
Pictures in molecular medicine: three-dimensional visualization of intravascular tumor cells in mice.
Trends in molecular medicine 2001;7(8):377.
2001: X Bai; Jillian R Brown; Ajit Varki; Jeffrey D Esko
Enhanced 3-O-sulfation of galactose in Asn-linked glycans and Maackia amurensis lectin binding in a new Chinese hamster ovary cell line.
Glycobiology 2001;11(8):621-32.
2001: Ajit Varki
N-glycolylneuraminic acid deficiency in humans.
Biochimie 2001;83(7):615-22.
2001: Pascal Gagneux; B Amess; Sandra Diaz; S Moore; T Patel; W Dillmann; Raj Parekh; Ajit Varki
Proteomic comparison of human and great ape blood plasma reveals conserved glycosylation and differences in thyroid hormone metabolism.
American journal of physical anthropology 2001;115(2):99-109.
2001: L D Powell; Ajit Varki; Hudson H Freeze
Release of saccharides from glycoconjugates.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 8():Unit 8.15.
2001: Sandra Diaz; Ajit Varki
Metabolic radiolabeling of animal cell glycoconjugates.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 8():Unit 8.13.
2001: Sandra Diaz; Ajit Varki
Metabolic radiolabeling of animal cell glycoconjugates.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Chapter 12():Unit 12.2.
2001: Ajit Varki; Hudson H Freeze; A E Manzi
Overview of glycoconjugate analysis.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Chapter 12():Unit 12.1.
2001: Geetha Srikrishna; K Panneerselvam; Vibeke Westphal; V Abraham; Ajit Varki; Hudson H Freeze
Two proteins modulating transendothelial migration of leukocytes recognize novel carboxylated glycans on endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4678-88.
2001: Lubor Borsig; R Wong; J Feramisco; D R Nadeau; Nissi M Varki; Ajit Varki
Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3352-7.
2001: Ajit Varki
Loss of N-glycolylneuraminic acid in humans: Mechanisms, consequences, and implications for hominid evolution.
American journal of physical anthropology 2001;Suppl 33():54-69.
2001: Pascal Gagneux; Ajit Varki
Genetic differences between humans and great apes.
Molecular phylogenetics and evolution 2001;18(1):2-13.
2001: Geetha Srikrishna; D K Toomre; A Manzi; K Panneerselvam; Hudson H Freeze; Ajit Varki; N M Varki
A novel anionic modification of N-glycans on mammalian endothelial cells is recognized by activated neutrophils and modulates acute inflammatory responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):624-32.
2000: Takashi Angata; Ajit Varki
Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways.
The Journal of biological chemistry 2000;275(29):22127-35.
2000: KE Norgard-Sumnicht; X Bai; Jeffrey D Esko; Ajit Varki; A E Manzi
Exploring the outcome of genetic modifications of glycosylation in cultured cell lines by concurrent isolation of the major classes of vertebrate glycans.
Glycobiology 2000;10(7):691-700.
2000: A E Manzi; KE Norgard-Sumnicht; S Argade; J D Marth; H van Halbeek; Ajit Varki
Exploring the glycan repertoire of genetically modified mice by isolation and profiling of the major glycan classes and nano-NMR analysis of glycan mixtures.
Glycobiology 2000;10(7):669-89.
2000: Takashi Angata; Ajit Varki
Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.
Glycobiology 2000;10(4):431-8.
2000: Els C M Brinkman-Van der Linden; E R Sjoberg; L R Juneja; P R Crocker; Nissi M Varki; Ajit Varki
Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs.
The Journal of biological chemistry 2000;275(12):8633-40.
2000: Els C M Brinkman-Van der Linden; Ajit Varki
New aspects of siglec binding specificities, including the significance of fucosylation and of the sialyl-Tn epitope. Sialic acid-binding immunoglobulin superfamily lectins.
The Journal of biological chemistry 2000;275(12):8625-32.
1999: N Razi; Ajit Varki
Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation.
Glycobiology 1999;9(11):1225-34.
1999: H Takematsu; S Diaz; A Stoddart; Y Zhang; Ajit Varki
Lysosomal and cytosolic sialic acid 9-O-acetylesterase activities can Be encoded by one gene via differential usage of a signal peptide-encoding exon at the N terminus.
The Journal of biological chemistry 1999;274(36):25623-31.
1999: Y J Kim; Lubor Borsig; H L Han; Nissi M Varki; Ajit Varki
Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes, and endothelium.
The American journal of pathology 1999;155(2):461-72.
1999: R Chammas; J L Sonnenburg; N E Watson; T Tai; M G Farquhar; N M Varki; Ajit Varki
De-N-acetyl-gangliosides in humans: unusual subcellular distribution of a novel tumor antigen.
Cancer research 1999;59(6):1337-46.
1998: Elaine A Muchmore; S Diaz; Ajit Varki
A structural difference between the cell surfaces of humans and the great apes.
American journal of physical anthropology 1998;107(2):187-98.
1998: H H Chou; H Takematsu; S Diaz; JC Iber; E Nickerson; K L Wright; Elaine A Muchmore; D L Nelson; Stephen Warren; Ajit Varki
A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11751-6.
1998: Y J Kim; Lubor Borsig; Nissi M Varki; Ajit Varki
P-selectin deficiency attenuates tumor growth and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9325-30.
1998: N Razi; Ajit Varki
Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7469-74.
1998: A Koenig; KE Norgard-Sumnicht; R Linhardt; Ajit Varki
Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents.
The Journal of clinical investigation 1998;101(4):877-89.
1998: W X Shi; R Chammas; Ajit Varki
Induction of sialic acid 9-O-acetylation by diverse gene products: implications for the expression cloning of sialic acid O-acetyltransferases.
Glycobiology 1998;8(2):199-205.
1997: Ajit Varki
Selectin ligands: will the real ones please stand up?
The Journal of clinical investigation 1997;100(11 Suppl):S31-5.
1997: Geetha Srikrishna; N M Varki; P C Newell; Ajit Varki; Hudson H Freeze
An IgG monoclonal antibody against Dictyostelium discoideum glycoproteins specifically recognizes Fucalpha1,6GlcNAcbeta in the core of N-linked glycans. Localized expression of core-fucosylated glycoconjugates in human tissues.
The Journal of biological chemistry 1997;272(41):25743-52.
1997: M Krishna; Ajit Varki
9-O-Acetylation of sialomucins: a novel marker of murine CD4 T cells that is regulated during maturation and activation.
The Journal of experimental medicine 1997;185(11):1997-2013.
1997: Ajit Varki
Sialic acids as ligands in recognition phenomena.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(4):248-55.
1997: A Koenig; R Jain; R Vig; KE Norgard-Sumnicht; Khushi L Matta; Ajit Varki
Selectin inhibition: synthesis and evaluation of novel sialylated, sulfated and fucosylated oligosaccharides, including the major capping group of GlyCAM-1.
Glycobiology 1997;7(1):79-93.
1997: Ajit Varki
Selectin ligands: will the real ones please stand up?
The Journal of clinical investigation 1997;99(2):158-62.
1996: B J Hicke; S R Watson; A Koenig; C K Lynott; Robert Bargatze; Y F Chang; S Ringquist; L Moon-McDermott; S Jennings; T Fitzwater; H L Han; Nissi M Varki; I Albinana; MC Willis; Ajit Varki; DH Parma
DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice.
The Journal of clinical investigation 1996;98(12):2688-92.
1996: W X Shi; R Chammas; N M Varki; L Powell; Ajit Varki
Sialic acid 9-O-acetylation on murine erythroleukemia cells affects complement activation, binding to I-type lectins, and tissue homing.
The Journal of biological chemistry 1996;271(49):31526-32.
1996: W X Shi; R Chammas; Ajit Varki
Regulation of sialic acid 9-O-acetylation during the growth and differentiation of murine erythroleukemia cells.
The Journal of biological chemistry 1996;271(49):31517-25.
1996: R Chammas; J M McCaffery; A Klein; Y Ito; L Saucan; GE Palade; Marilyn G Farquhar; Ajit Varki
Uptake and incorporation of an epitope-tagged sialic acid donor into intact rat liver Golgi compartments. Functional localization of sialyltransferase overlaps with beta-galactosyltransferase but not with sialic acid O-acetyltransferase.
Molecular biology of the cell 1996;7(11):1691-707.
1996: Ajit Varki
"Unusual" modifications and variations of vertebrate oligosaccharides: are we missing the flowers for the trees?
Glycobiology 1996;6(7):707-10.
1996: W X Shi; R Chammas; Ajit Varki
Linkage-specific action of endogenous sialic acid O-acetyltransferase in Chinese hamster ovary cells.
The Journal of biological chemistry 1996;271(25):15130-8.
1996: D O'Connell; A Koenig; S Jennings; B Hicke; H L Han; T Fitzwater; Y F Chang; Nissi M Varki; DH Parma; Ajit Varki
Calcium-dependent oligonucleotide antagonists specific for L-selectin.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5883-7.
1996: Ajit Varki
Does DG42 synthesize hyaluronan or chitin?: A controversy about oligosaccharides in vertebrate development.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4523-5.
1995: K E Norgard-Sumnicht; L Roux; D K Toomre; A Manzi; Hudson H Freeze; Ajit Varki
Unusual anionic N-linked oligosaccharides from bovine lung.
The Journal of biological chemistry 1995;270(46):27634-45.
1995: B K Hayes; F Esquivel; Jack R Bennink; jon yewdell; Ajit Varki
Structure of the N-linked oligosaccharides of MHC class I molecules from cells deficient in the antigenic peptide transporter. Implications for the site of peptide association.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3780-7.
1995: G Mannori; P Crottet; O Cecconi; K Hanasaki; A Aruffo; R M Nelson; Ajit Varki; M P Bevilacqua
Differential colon cancer cell adhesion to E-, P-, and L-selectin: role of mucin-type glycoproteins.
Cancer research 1995;55(19):4425-31.
1995: K Norgard-Sumnicht; Ajit Varki
Endothelial heparan sulfate proteoglycans that bind to L-selectin have glucosamine residues with unsubstituted amino groups.
The Journal of biological chemistry 1995;270(20):12012-24.
1995: K Hanasaki; Ajit Varki; L D Powell
CD22-mediated cell adhesion to cytokine-activated human endothelial cells. Positive and negative regulation by alpha 2-6-sialylation of cellular glycoproteins.
The Journal of biological chemistry 1995;270(13):7533-42.
1995: L D Powell; R K Jain; K L Matta; S Sabesan; Ajit Varki
Characterization of sialyloligosaccharide binding by recombinant soluble and native cell-associated CD22. Evidence for a minimal structural recognition motif and the potential importance of multisite binding.
The Journal of biological chemistry 1995;270(13):7523-32.
1995: E R Sjoberg; R Chammas; H Ozawa; I Kawashima; K H Khoo; H R Morris; A Dell; T Tai; Ajit Varki
Expression of de-N-acetyl-gangliosides in human melanoma cells is induced by genistein or nocodazole.
The Journal of biological chemistry 1995;270(7):2921-30.
1994: L D Powell; K Paneerselvam; R Vij; S Diaz; A Manzi; N Buist; Hudson H Freeze; Ajit Varki
Carbohydrate-deficient glycoprotein syndrome: not an N-linked oligosaccharide processing defect, but an abnormality in lipid-linked oligosaccharide biosynthesis?
The Journal of clinical investigation 1994;94(5):1901-9.
1994: A E Manzi; H H Higa; S Diaz; Ajit Varki
Intramolecular self-cleavage of polysialic acid.
The Journal of biological chemistry 1994;269(38):23617-24.
1994: A Klein; M Krishna; N M Varki; Ajit Varki
9-O-acetylated sialic acids have widespread but selective expression: analysis using a chimeric dual-function probe derived from influenza C hemagglutinin-esterase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7782-6.
1994: Ajit Varki
Selectin ligands.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7390-7.
1994: E R Sjoberg; L D Powell; A Klein; Ajit Varki
Natural ligands of the B cell adhesion molecule CD22 beta can be masked by 9-O-acetylation of sialic acids.
The Journal of cell biology 1994;126(2):549-62.
1994: K Hanasaki; Ajit Varki; I Stamenkovic; M P Bevilacqua
Cytokine-induced beta-galactoside alpha-2,6-sialyltransferase in human endothelial cells mediates alpha 2,6-sialylation of adhesion molecules and CD22 ligands.
The Journal of biological chemistry 1994;269(14):10637-43.
1994: L D Powell; Ajit Varki
The oligosaccharide binding specificities of CD22 beta, a sialic acid-specific lectin of B cells.
The Journal of biological chemistry 1994;269(14):10628-36.
1994: Ajit Varki
Metabolic radiolabeling of glycoconjugates.
Methods in enzymology 1994;230():16-32.
1993: B E Rothenberg; B K Hayes; D Toomre; A E Manzi; Ajit Varki
Biotinylated diaminopyridine: an approach to tagging oligosaccharides and exploring their biology.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11939-43.
1993: B K Hayes; Ajit Varki
The biosynthesis of oligosaccharides in intact Golgi preparations from rat liver. Analysis of N-linked and O-linked glycans labeled by UDP-[6-3H]N-acetylgalactosamine.
The Journal of biological chemistry 1993;268(22):16170-8.
1993: B K Hayes; Ajit Varki
Biosynthesis of oligosaccharides in intact Golgi preparations from rat liver. Analysis of N-linked glycans labeled by UDP-[6-3H]galactose, CMP-[9-3H]N-acetylneuraminic acid, and [acetyl-3H]acetyl-coenzyme A.
The Journal of biological chemistry 1993;268(22):16155-69.
1993: B K Hayes; Hudson H Freeze; Ajit Varki
Biosynthesis of oligosaccharides in intact Golgi preparations from rat liver. Analysis of N-linked glycans labeled by UDP-[6-3H]N-acetylglucosamine.
The Journal of biological chemistry 1993;268(22):16139-54.
1993: K E Norgard; Kevin L Moore; S Diaz; N L Stults; S Ushiyama; Rodger P McEver; Richard D Cummings; Ajit Varki
Characterization of a specific ligand for P-selectin on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides.
The Journal of biological chemistry 1993;268(17):12764-74.
1993: C Butor; H H Higa; Ajit Varki
Structural, immunological, and biosynthetic studies of a sialic acid-specific O-acetylesterase from rat liver.
The Journal of biological chemistry 1993;268(14):10207-13.
1993: C Butor; S Diaz; Ajit Varki
High level O-acetylation of sialic acids on N-linked oligosaccharides of rat liver membranes. Differential subcellular distribution of 7- and 9-O-acetyl groups and of enzymes involved in their regulation.
The Journal of biological chemistry 1993;268(14):10197-206.
1993: E R Sjoberg; Ajit Varki
Kinetic and spatial interrelationships between ganglioside glycosyltransferases and O-acetyltransferase(s) in human melanoma cells.
The Journal of biological chemistry 1993;268(14):10185-96.
1993: L D Powell; D Sgroi; E R Sjoberg; Ivan Stamenkovic; Ajit Varki
Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition.
The Journal of biological chemistry 1993;268(10):7019-27.
1993: D Sgroi; Ajit Varki; S Braesch-Andersen; Ivan Stamenkovic
CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin.
The Journal of biological chemistry 1993;268(10):7011-8.
1993: K E Norgard; H Han; L Powell; M Kriegler; Ajit Varki; N M Varki
Enhanced interaction of L-selectin with the high endothelial venule ligand via selectively oxidized sialic acids.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(3):1068-72.
1992: E R Sjoberg; A E Manzi; K H Khoo; A Dell; Ajit Varki
Structural and immunological characterization of O-acetylated GD2. Evidence that GD2 is an acceptor for ganglioside O-acetyltransferase in human melanoma cells.
The Journal of biological chemistry 1992;267(23):16200-11.
1992: Kevin L Moore; N L Stults; S Diaz; David Smith; Richard D Cummings; Ajit Varki; Rodger P McEver
Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells.
The Journal of cell biology 1992;118(2):445-56.
1992: Ajit Varki
Selectins and other mammalian sialic acid-binding lectins.
Current opinion in cell biology 1992;4(2):257-66.
1991: Ajit Varki; Farideh Hooshmand; S Diaz; N M Varki; Stephen M Hedrick
Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase.
Cell 1991;65(1):65-74.
1991: Kevin L Moore; Ajit Varki; Rodger P McEver
GMP-140 binds to a glycoprotein receptor on human neutrophils: evidence for a lectin-like interaction.
The Journal of cell biology 1991;112(3):491-9.
1990: A E Manzi; E R Sjoberg; S Diaz; Ajit Varki
Biosynthesis and turnover of O-acetyl and N-acetyl groups in the gangliosides of human melanoma cells.
The Journal of biological chemistry 1990;265(22):13091-103.
1990: A E Manzi; A Dell; P Azadi; Ajit Varki
Studies of naturally occurring modifications of sialic acids by fast-atom bombardment-mass spectrometry. Analysis of positional isomers by periodate cleavage.
The Journal of biological chemistry 1990;265(14):8094-107.
1989: E A Muchmore; M Milewski; Ajit Varki; S Diaz
Biosynthesis of N-glycolyneuraminic acid. The primary site of hydroxylation of N-acetylneuraminic acid is the cytosolic sugar nucleotide pool.
The Journal of biological chemistry 1989;264(34):20216-23.
1989: H H Higa; A Manzi; Ajit Varki
O-acetylation and de-O-acetylation of sialic acids. Purification, characterization, and properties of a glycosylated rat liver esterase specific for 9-O-acetylated sialic acids.
The Journal of biological chemistry 1989;264(32):19435-42.
1989: S Diaz; H H Higa; B K Hayes; Ajit Varki
O-acetylation and de-O-acetylation of sialic acids. 7- and 9-o-acetylation of alpha 2,6-linked sialic acids on endogenous N-linked glycans in rat liver Golgi vesicles.
The Journal of biological chemistry 1989;264(32):19416-26.
1989: B K Hayes; Ajit Varki
O-acetylation and de-O-acetylation of sialic acids. Sialic acid esterases of diverse evolutionary origins have serine active sites and essential arginine residues.
The Journal of biological chemistry 1989;264(32):19443-8.
1989: H H Higa; C Butor; S Diaz; Ajit Varki
O-acetylation and de-O-acetylation of sialic acids. O-acetylation of sialic acids in the rat liver Golgi apparatus involves an acetyl intermediate and essential histidine and lysine residues--a transmembrane reaction?
The Journal of biological chemistry 1989;264(32):19427-34.
1989: S Diaz; H H Higa; Ajit Varki
Glycoprotein sialate 7(9)-O-acetyltransferase from rat liver Golgi vesicles.
Methods in enzymology 1989;179():416-22.
1989: H H Higa; A Manzi; S Diaz; Ajit Varki
Sialate 9-O-acetylesterase from rat liver.
Methods in enzymology 1989;179():409-15.
1988: G Sundblad; S Kajiji; V Quaranta; Hudson H Freeze; Ajit Varki
Sulfated N-linked oligosaccharides in mammalian cells. III. Characterization of a pancreatic carcinoma cell surface glycoprotein with N- and O-sulfate esters on asparagine-linked glycans.
The Journal of biological chemistry 1988;263(18):8897-903.
1988: G Sundblad; S Holojda; L Roux; Ajit Varki; Hudson H Freeze
Sulfated N-linked oligosaccharides in mammalian cells. II. Identification of glycosaminoglycan-like chains attached to complex-type glycans.
The Journal of biological chemistry 1988;263(18):8890-6.
1988: L Roux; S Holojda; G Sundblad; Hudson H Freeze; Ajit Varki
Sulfated N-linked oligosaccharides in mammalian cells. I. Complex-type chains with sialic acids and O-sulfate esters.
The Journal of biological chemistry 1988;263(18):8879-89.
1988: H H Higa; Ajit Varki
Acetyl-coenzyme A:polysialic acid O-acetyltransferase from K1-positive Escherichia coli. The enzyme responsible for the O-acetyl plus phenotype and for O-acetyl form variation.
The Journal of biological chemistry 1988;263(18):8872-8.
1987: H H Higa; S Diaz; Ajit Varki
Biochemical and genetic evidence for distinct membrane-bound and cytosolic sialic acid O-acetyl-esterases: serine-active-site enzymes.
Biochemical and biophysical research communications 1987;144(3):1099-108.