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Manthena Varma

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TOP 3
Manthena V S Varma; Bo Feng; Theunis C Goosen; Yurong Lai; John Litchfield; Arthur Bergman
Response to the comment on the article "physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions".
Manthena V S Varma; Justine L Lam; Jian Lin; Charles J Rotter; Yi-An Bi; Ayman El-Kattan; Odette A Fahmi; Theunis C Goosen; Yurong Lai
Quantitative Prediction of Repaglinide-Rifampicin Complex Drug Interactions Using Dynamic and Static Mechanistic Models: Delineating Differential CYP3A4 Induction and OATP1B1 Inhibition Potential of Rifampicin.
Hugh A Barton; Ayman El-Kattan; Theunis C Goosen; James R Gosset; Hannah M Jones; Yurong Lai; Jian Lin; Manthena V S Varma
Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.

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All Publications

2013: Manthena V S Varma; Bo Feng; Theunis C Goosen; Yurong Lai; John Litchfield; Arthur Bergman
Response to the comment on the article "physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions".
Pharmaceutical research 2013;30(6):1469-70.
2013: Manthena V S Varma; Justine L Lam; Jian Lin; Charles J Rotter; Yi-An Bi; Ayman El-Kattan; Odette A Fahmi; Theunis C Goosen; Yurong Lai
Quantitative Prediction of Repaglinide-Rifampicin Complex Drug Interactions Using Dynamic and Static Mechanistic Models: Delineating Differential CYP3A4 Induction and OATP1B1 Inhibition Potential of Rifampicin.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(5):966-74.
2013: Hugh A Barton; Ayman El-Kattan; Theunis C Goosen; James R Gosset; Hannah M Jones; Yurong Lai; Jian Lin; Manthena V S Varma
Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.
Expert opinion on drug metabolism & toxicology 2013;9(4):459-72.
2013: Manthena V S Varma; Yurong Lai; Ayman El-Kattan; Theunis C Goosen; Emi Kimoto; Vikas Kumar
Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide.
Pharmaceutical research 2013;30(4):1188-99.
2012: Manthena V S Varma; Bo Feng; Theunis C Goosen; Yurong Lai; John Litchfield; Arthur Bergman
Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions.
Pharmaceutical research 2012;29(10):2860-73.
2012: Manthena V S Varma; Yurong Lai; John Litchfield; George Chang; Ayman El-Kattan; Bo Feng; Theunis C Goosen
Physicochemical property space of hepatobiliary transport and computational models for predicting rat biliary excretion.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(8):1527-37.
2012: Manthena V S Varma; Carrie Whitney-Pickett; Hui Zhang; Michael Cram; Li Di; Katherine S Fenner; Iain Gardner; Paul Nkansah; Charles J Rotter; Stefanus J Steyn; Ayman El-Kattan
pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.
Molecular pharmaceutics 2012;9(5):1199-212.
2011: Li Di; Ayman El-Kattan; James J Federico; Bo Feng; Katherine Fenner; David F Gebhard; Sarah Kempshall; Yurong Lai; Caroline Lee; Theodore E Liston; Eric L Reyner; Charles Rotter; Russ Smith; John P Umland; Manthena V S Varma; Carrie Whitney-Pickett; Hui Zhang; Xun Zhang; Ralph E Davidson; Matthew D Troutman
Development of a new permeability assay using low-efflux MDCKII cells.
Journal of pharmaceutical sciences 2011;100(11):4974-85.
2010: André H Eriksson; Manthena V S Varma; Everett J Perkins; Cheryl L Zimmerman
The intestinal absorption of a prodrug of the mGlu2/3 receptor agonist LY354740 is mediated by PEPT1: in situ rat intestinal perfusion studies.
Journal of pharmaceutical sciences 2010;99(3):1574-81.
2010: Manthena V S Varma; R Scott Obach; Charles Rotter; Howard R Miller; George Chang; Stefanus J Steyn; Ayman El-Kattan; Matthew D Troutman
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Journal of medicinal chemistry 2010;53(3):1098-108.
2009: Manthena V S Varma; Bo Feng; R Scott Obach; Matthew D Troutman; Jonathan Chupka; Howard R Miller; Ayman El-Kattan
Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry 2009;52(15):4844-52.
2006: Manthena V S Varma; Omathanu P Perumal; Ramesh Panchagnula
Functional role of P-glycoprotein in limiting peroral drug absorption: optimizing drug delivery.
Current opinion in chemical biology 2006;10(4):367-73.
2006: Ramesh Panchagnula; A Gupta; S Kandavilli; Manthena V S Varma
High-throughput evaluation of non-swellable controlled release matrix tablets.
Drug development and industrial pharmacy 2006;32(6):669-75.
2006: Yasvanth Ashokraj; Gunjan Kohli; kanwal jeet kaur; Shantaram R Bhade; Manthena V S Varma; Mahua Sarkar; Namita Kapoor; Inderjit Singh; Sateesh Kandavilli; Ramesh Panchagnula
Feasibility studies on division of fixed dose combinations of anti-tubercular drugs: an improvement in the tuberculosis therapy.
Journal of clinical pharmacy and therapeutics 2006;31(2):201-3.
2005: Ramesh Panchagnula; Tripta Bansal; Manthena V S Varma; Chaman Lal Kaul
Co-treatment with grapefruit juice inhibits while chronic administration activates intestinal P-glycoprotein-mediated drug efflux.
Die Pharmazie 2005;60(12):922-7.
2005: Manthena V S Varma; Ramesh Panchagnula
pH-dependent functional activity of P-glycoprotein in limiting intestinal absorption of protic drugs: kinetic analysis of quinidine efflux in situ.
Journal of pharmaceutical sciences 2005;94(12):2632-43.
2005: Pradeep Sharma; Manthena V S Varma; Harmander P S Chawla; Ramesh Panchagnula
In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies.
Farmaco (Società chimica italiana : 1989) 2005;60(11-12):874-83.
2005: Pradeep Sharma; Manthena V S Varma; Harmander P S Chawla; Ramesh Panchagnula
Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers.
Farmaco (Società chimica italiana : 1989) 2005;60(11-12):884-93.
2005: Pradeep Sharma; Manthena V S Varma; Harmander P S Chawla; Ramesh Panchagnula
Relationship between lipophilicity of BCS class III and IV drugs and the functional activity of peroral absorption enhancers.
Farmaco (Società chimica italiana : 1989) 2005;60(11-12):870-3.
2005: Manthena V S Varma; Ramesh Panchagnula
Prediction of in vivo intestinal absorption enhancement on P-glycoprotein inhibition, from rat in situ permeability.
Journal of pharmaceutical sciences 2005;94(8):1694-704.
2005: Yasvanth Ashokraj; Inderjit Singh; Kanwal Jit Kaur; Gunjan Kohli; Shantaram R Bhade; Manthena V S Varma; Chaman Lal Kaul; Ramesh Panchagnula
Establishment of a reference formulation for bioequivalence assessment of rifampicin-containing FDCs: an essential step towards improving tuberculosis treatment.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2005;9(7):791-6.
2005: Manthena V S Varma; Ramesh Panchagnula
Enhanced oral paclitaxel absorption with vitamin E-TPGS: effect on solubility and permeability in vitro, in situ and in vivo.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;25(4-5):445-53.
2005: Yasvanth Ashokraj; Inderjit Singh; Kanwal Jit Kaur; Gunjan Kohli; Shantaram R Bhade; Manthena V S Varma; Chaman Lal Kaul; Ramesh Panchagnula
Plasma pooling: utility in expediting bioequivalence assessment of rifampicin-containing fixed-dose combinations.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2005;9(6):697-9.
2005: Manthena V S Varma; Aditya Mohan Kaushal; Sanjay Garg
Influence of micro-environmental pH on the gel layer behavior and release of a basic drug from various hydrophilic matrices.
Journal of controlled release : official journal of the Controlled Release Society 2005;103(2):499-510.
2005: Manthena V S Varma; Mahua Sarkar; Namita Kapoor; Ramesh Panchagnula
pH-dependent functional activity of P-glycoprotein in limiting intestinal absorption of protic drugs 1. Simultaneous determination of quinidine and permeability markers in rat in situ perfusion samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;816(1-2):243-9.
2005: Manthena V S Varma; Sateesh Kandavilli; Ramesh Panchagnula
Functional role of P-glycoprotein in limiting intestinal absorption of drugs: contribution of passive permeability to P-glycoprotein mediated efflux transport.
Molecular pharmaceutics 2005;2(1):12-21.
2004: Manthena V S Varma; Namita Kapoor; Mahua Sarkar; Ramesh Panchagnula
Simultaneous determination of digoxin and permeability markers in rat in situ intestinal perfusion samples by RP-HPLC.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;813(1-2):347-52.
2004: Manthena V S Varma; Aditya Mohan Kaushal; Sanjay Garg
Rapid and selective UV spectrophotometric and RP-HPLC methods for dissolution studies of oxybutynin immediate-release and controlled-release formulations.
Journal of pharmaceutical and biomedical analysis 2004;36(3):669-74.
2004: Manthena V S Varma; Sateesh Kandavilli; Yasvanth Ashokraj; Amit Jain; Anand Babu Dhanikula; Anurag Sood; Narisetty S Thomas; Omathanu Pillai; Pradeep Sharma; Rajesh Gandhi; Shrutidevi Agrawal; Vinod Nair; Ramesh Panchagnula
Biopharmaceutic classification system: a scientific framework for pharmacokinetic optimization in drug research.
Current drug metabolism 2004;5(5):375-88.
2004: Ramesh Panchagnula; Puneet Sharma; Sateesh Kandavilli; Manthena V S Varma
RP-HPLC method and its validation for the determination of naloxone from a novel transdermal formulation.
Farmaco (Società chimica italiana : 1989) 2004;59(10):839-42.
2004: Yasvanth Ashokraj; Shrutidevi Agrawal; Manthena V S Varma; Inderjit Singh; K Gunjan; Kanwal Jit Kaur; Shantaram R Bhade; Chaman Lal Kaul; J M Caudron; J Pinel; Ramesh Panchagnula
Quality control of anti-tuberculosis fixed-dose combination formulations in the global market: an in vitro study.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2004;8(9):1081-8.
2004: Ramesh Panchagnula; Tripta Bansal; Manthena V S Varma; Chaman Lal Kaul
Reversed-phase liquid chromatography with ultraviolet detection for simultaneous quantitation of indinavir and propranolol from ex-vivo rat intestinal permeability studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;806(2):277-82.
2003: Manthena V S Varma; Yasvanth Ashokraj; Chinmoy S Dey; Ramesh Panchagnula
P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement.
Pharmacological research : the official journal of the Italian Pharmacological Society 2003;48(4):347-59.