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Harold Varmus

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Neoplastic Cell Transformation

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Co-Publications
Name
113
Bishop, John
9
Kung, Hsing-Jien
9
Podsypanina, Katrina
9
Pao, William
8
Li, Yi
8
Pastan, Ira
6
Chamorro, Mario
5
Cong, Feng
5
Bates, Paul
5
Kris, Mark
5
Klimstra, David
5
Hively, WP
5
Lewis, Brian
5
Politi, Katerina
5
Zakowski, Maureen

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Publications

TOP 3
Jechlinger Martin; Podsypanina Katrina; Varmus Harold
Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction.
Gottfried Kurt; Varmus Harold
The enlightenment returns.
Beverly L J; Varmus H E
MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family.

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All Publications

2009: Jechlinger Martin; Podsypanina Katrina; Varmus Harold
Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction.
Genes & development 2009;23(14):1677-88.
2009: Gottfried Kurt; Varmus Harold
The enlightenment returns.
Science (New York, N.Y.) 2009;323(5921):1538.
2009: Beverly L J; Varmus H E
MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family.
Oncogene 2009;28(9):1274-9.
2009: Du Yi-Chieh Nancy; Klimstra David S; Varmus Harold
Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors.
PloS one 2009;4(9):e6932.
2008: Ding Li; Getz Gad; Wheeler David A; Mardis Elaine R; McLellan Michael D; Cibulskis Kristian; Sougnez Carrie; Greulich Heidi; Muzny Donna M; Morgan Margaret B; Fulton Lucinda; Fulton Robert S; Zhang Qunyuan; Wendl Michael C; Lawrence Michael S; Larson David E; Chen Ken; Dooling David J; Sabo Aniko; Hawes Alicia C; Shen Hua; Jhangiani Shalini N; Lewis Lora R; Hall Otis; Zhu Yiming; Mathew Tittu; Ren Yanru; Yao Jiqiang; Scherer Steven E; Clerc Kerstin; Metcalf Ginger A; Ng Brian; Milosavljevic Aleksandar; Gonzalez-Garay Manuel L; Osborne John R; Meyer Rick; Shi Xiaoqi; Tang Yuzhu; Koboldt Daniel C; Lin Ling; Abbott Rachel; Miner Tracie L; Pohl Craig; Fewell Ginger; Haipek Carrie; Schmidt Heather; Dunford-Shore Brian H; Kraja Aldi; Crosby Seth D; Sawyer Christopher S; Vickery Tammi; Sander Sacha; Robinson Jody; Winckler Wendy; Baldwin Jennifer; Chirieac Lucian R; Dutt Amit; Fennell Tim; Hanna Megan; Johnson Bruce E; Onofrio Robert C; Thomas Roman K; Tonon Giovanni; Weir Barbara A; Zhao Xiaojun; Ziaugra Liuda; Zody Michael C; Giordano Thomas; Orringer Mark B; Roth Jack A; Spitz Margaret R; Wistuba Ignacio I; Ozenberger Bradley; Good Peter J; Chang Andrew C; Beer David G; Watson Mark A; Ladanyi Marc; Broderick Stephen; Yoshizawa Akihiko; Travis William D; Pao William; Province Michael A; Weinstock George M; Varmus Harold E; Gabriel Stacey B; Lander Eric S; Gibbs Richard A; Meyerson Matthew; Wilson Richard K
Somatic mutations affect key pathways in lung adenocarcinoma.
Nature 2008;455(7216):1069-75.
2008: Guha Udayan; Chaerkady Raghothama; Marimuthu Arivusudar; Patterson A Scott; Kashyap Manoj K; Harsha H C; Sato Mitsuo; Bader Joel S; Lash Alex E; Minna John D; Pandey Akhilesh; Varmus Harold E
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):14112-7.
2008: Podsypanina Katrina; Du Yi-Chieh Nancy; Jechlinger Martin; Beverly Levi J; Hambardzumyan Dolores; Varmus Harold
Seeding and propagation of untransformed mouse mammary cells in the lung.
Science (New York, N.Y.) 2008;321(5897):1841-4.
2008: Varmus Harold E; Vogt Peter K; Bishop J Michael
The classic: integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts: (RNA tumor viruses/reassociation kinetics/duck cells). 1973.
Clinical orthopaedics and related research 2008;466(9):2031-8.
2008: Varmus Harold
Harold Varmus. Interview by Errol C. Friedberg.
Nature reviews. Molecular cell biology 2008;9(7):502-3.
2008: Varmus Harold
NIH funds support more than a researcher's own lab.
Nature 2008;452(7189):811.
2008: Varmus Harold
Progress toward public access to science.
PLoS biology 2008;6(4):e101.
2008: Podsypanina Katrina; Politi Katerina; Beverly Levi J; Varmus Harold E
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5242-7.
2007: Weir Barbara A; Woo Michele S; Getz Gad; Perner Sven; Ding Li; Beroukhim Rameen; Lin William M; Province Michael A; Kraja Aldi; Johnson Laura A; Shah Kinjal; Sato Mitsuo; Thomas Roman K; Barletta Justine A; Borecki Ingrid B; Broderick Stephen; Chang Andrew C; Chiang Derek Y; Chirieac Lucian R; Cho Jeonghee; Fujii Yoshitaka; Gazdar Adi F; Giordano Thomas; Greulich Heidi; Hanna Megan; Johnson Bruce E; Kris Mark G; Lash Alex; Lin Ling; Lindeman Neal; Mardis Elaine R; McPherson John D; Minna John D; Morgan Margaret B; Nadel Mark; Orringer Mark B; Osborne John R; Ozenberger Brad; Ramos Alex H; Robinson James; Roth Jack A; Rusch Valerie; Sasaki Hidefumi; Shepherd Frances; Sougnez Carrie; Spitz Margaret R; Tsao Ming-Sound; Twomey David; Verhaak Roel G W; Weinstock George M; Wheeler David A; Winckler Wendy; Yoshizawa Akihiko; Yu Soyoung; Zakowski Maureen F; Zhang Qunyuan; Beer David G; Wistuba Ignacio I; Watson Mark A; Garraway Levi A; Ladanyi Marc; Travis William D; Pao William; Rubin Mark A; Gabriel Stacey B; Gibbs Richard A; Varmus Harold E; Wilson Richard K; Lander Eric S; Meyerson Matthew
Characterizing the cancer genome in lung adenocarcinoma.
Nature 2007;450(7171):893-8.
2007: Du Yi-Chieh Nancy; Lewis Brian C; Hanahan Douglas; Varmus Harold
Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion.
PLoS biology 2007;5(10):e276.
2007: Marks Jenifer L; McLellan Michael D; Zakowski Maureen F; Lash Alex E; Kasai Yumi; Broderick Stephen; Sarkaria Inderpal S; Pham Duykhanh; Singh Bhuvanesh; Miner Tracie L; Fewell Ginger A; Fulton Lucinda L; Mardis Elaine R; Wilson Richard K; Kris Mark G; Rusch Valerie W; Varmus Harold; Pao William
Mutational analysis of EGFR and related signaling pathway genes in lung Adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.
PloS one 2007;2(5):e426.
2006: Du Zhijun; Podsypanina Katrina; Huang Shixia; McGrath Amanda; Toneff Michael J; Bogoslovskaia Ekaterina; Zhang Xiaomei; Moraes Ricardo C; Fluck Michele; Allred D Craig; Lewis Michael T; Varmus Harold E; Li Yi
Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17396-401.
2006: Politi Katerina; Zakowski Maureen F; Fan Pang-Dian; Schonfeld Emily A; Pao William; Varmus Harold E
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.
Genes & development 2006;20(11):1496-510.
2006: Varmus Harold
The new era in cancer research.
Science (New York, N.Y.) 2006;312(5777):1162-5.
2006: Bishop J Michael; Varmus Harold
Re-aim blame for NIH's hard times.
Science (New York, N.Y.) 2006;312(5773):499.
2005: Varmus Harold; Stillman Bruce
Support for the Human Cancer Genome Project.
Science (New York, N.Y.) 2005;310(5754):1615.
2005: Carter Todd A; Wodicka Lisa M; Shah Neil P; Velasco Anne Marie; Fabian Miles A; Treiber Daniel K; Milanov Zdravko V; Atteridge Corey E; Biggs William H; Edeen Philip T; Floyd Mark; Ford Julia M; Grotzfeld Robert M; Herrgard Sanna; Insko Darren E; Mehta Shamal A; Patel Hitesh K; Pao William; Sawyers Charles L; Varmus Harold; Zarrinkar Patrick P; Lockhart David J
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):11011-6.
2005: Pao William; Miller Vincent A; Politi Katerina A; Riely Gregory J; Somwar Romel; Zakowski Maureen F; Kris Mark G; Varmus Harold
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.
PLoS medicine 2005;2(3):e73.
2005: Lewis Brian C; Klimstra David S; Socci Nicholas D; Xu Su; Koutcher Jason A; Varmus Harold E
The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma.
Molecular and cellular biology 2005;25(4):1228-37.
2005: Pao William; Wang Theresa Y; Riely Gregory J; Miller Vincent A; Pan Qiulu; Ladanyi Marc; Zakowski Maureen F; Heelan Robert T; Kris Mark G; Varmus Harold E
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib.
PLoS medicine 2005;2(1):e17.
2005: Chamorro Mario N; Schwartz Donald R; Vonica Alin; Brivanlou Ali H; Cho Kathleen R; Varmus Harold E
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.
The EMBO journal 2005;24(1):73-84.
2005: Varmus H; Pao W; Politi K; Podsypanina K; Du Y-C N
Oncogenes come of age.
Cold Spring Harbor symposia on quantitative biology 2005;70():1-9.
2005: Huang Shixia; Li Yi; Chen Yidong; Podsypanina Katrina; Chamorro Mario; Olshen Adam B; Desai Kartiki V; Tann Anne; Petersen David; Green Jeffrey E; Varmus Harold E
Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice.
Genome biology 2005;6(10):R84.
2004: Cong Feng; Schweizer Liang; Varmus Harold
Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.
Development (Cambridge, England) 2004;131(20):5103-15.
2004: Austin Christopher P; Battey James F; Bradley Allan; Bucan Maja; Capecchi Mario; Collins Francis S; Dove William F; Duyk Geoffrey; Dymecki Susan; Eppig Janan T; Grieder Franziska B; Heintz Nathaniel; Hicks Geoff; Insel Thomas R; Joyner Alexandra; Koller Beverly H; Lloyd K C Kent; Magnuson Terry; Moore Mark W; Nagy Andras; Pollock Jonathan D; Roses Allen D; Sands Arthur T; Seed Brian; Skarnes William C; Snoddy Jay; Soriano Philippe; Stewart David J; Stewart Francis; Stillman Bruce; Varmus Harold; Varticovski Lyuba; Verma Inder M; Vogt Thomas F; von Melchner Harald; Witkowski Jan; Woychik Richard P; Wurst Wolfgang; Yancopoulos George D; Young Stephen G; Zambrowicz Brian
The knockout mouse project.
Nature genetics 2004;36(9):921-4.
2004: Pao William; Miller Vincent; Zakowski Maureen; Doherty Jennifer; Politi Katerina; Sarkaria Inderpal; Singh Bhuvanesh; Heelan Robert; Rusch Valerie; Fulton Lucinda; Mardis Elaine; Kupfer Doris; Wilson Richard; Kris Mark; Varmus Harold
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13306-11.
2004: Podsypanina Katrina; Li Yi; Varmus Harold E
Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype.
BMC medicine 2004;2():24.
2004: Cong Feng; Varmus Harold
Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2882-7.
2004: Cong Feng; Schweizer Liang; Varmus Harold
Casein kinase Iepsilon modulates the signaling specificities of dishevelled.
Molecular and cellular biology 2004;24(5):2000-11.
2003: Lewis Brian C; Klimstra David S; Varmus Harold E
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer.
Genes & development 2003;17(24):3127-38.
2003: Li Yi; Welm Bryan; Podsypanina Katrina; Huang Shixia; Chamorro Mario; Zhang Xiaomei; Rowlands Tracey; Egeblad Mikala; Cowin Pam; Werb Zena; Tan Lee K; Rosen Jeffrey M; Varmus Harold E
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15853-8.
2003: Cong Feng; Schweizer Liang; Chamorro Mario; Varmus Harold
Requirement for a nuclear function of beta-catenin in Wnt signaling.
Molecular and cellular biology 2003;23(23):8462-70.
2003: Varmus H; Klausner R; Zerhouni E; Acharya T; Daar A S; Singer P A
Public health. Grand Challenges in Global Health.
Science (New York, N.Y.) 2003;302(5644):398-9.
2003: Brown Patrick O; Eisen Michael B; Varmus Harold E
Why PLoS became a publisher.
PLoS biology 2003;1(1):E36.
2003: Varmus Harold
Genomic empowerment: the importance of public databases.
Nature genetics 2003;35 Suppl 1():3.
2003: Cong Feng; Zhang Jianxuan; Pao William; Zhou Pengbo; Varmus Harold
A protein knockdown strategy to study the function of beta-catenin in tumorigenesis.
BMC molecular biology 2003;4():10.
2003: Pao William; Klimstra David S; Fisher Galen H; Varmus Harold E
Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8764-9.
2003: Klausner Richard D; Fauci Anthony S; Corey Lawrence; Nabel Gary J; Gayle Helene; Berkley Seth; Haynes Barton F; Baltimore David; Collins Chris; Douglas R Gordon; Esparza Jose; Francis Donald P; Ganguly N K; Gerberding Julie Louise; Johnston Margaret I; Kazatchkine Michel D; McMichael Andrew J; Makgoba Malegapuru W; Pantaleo Giuseppe; Piot Peter; Shao Yiming; Tramont Edmund; Varmus Harold; Wasserheit Judith N
Medicine. The need for a global HIV vaccine enterprise.
Science (New York, N.Y.) 2003;300(5628):2036-9.
2003: Schweizer Liang; Varmus Harold
Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors.
BMC cell biology 2003;4():4.
2003: Atlas Ronald; Campbell Philip; Cozzarelli Nicholas R; Curfman Greg; Enquist Lynn; Fink Gerald; Flanagin Annette; Fletcher Jacqueline; George Elizabeth; Hammes Gordon; Heyman David; Inglesby Thomas; Kaplan Samuel; Kennedy Donald; Krug Judith; Levinson Rachel; Marcus Emilie; Metzger Henry; Morse Stephen S; O'Brien Alison; Onderdonk Andrew; Poste George; Renault Beatrice; Rich Robert; Rosengard Ariella; Salzburg Steven; Scanlan Mary; Shenk Thomas; Tabor Herbert; Varmus Harold; Wimmer Eckard; Yamamoto Keith;
Statement on scientific publication and security.
Science (New York, N.Y.) 2003;299(5610):1149.
2003: Atlas Ronald; Campbell Philip; Cozzarelli Nicholas R; Curfman Greg; Enquist Lynn; Fink Gerald; Flanagin Annette; Fletcher Jacqueline; George Elizabeth; Hammes Gordon; Heyman David; Inglesby Thomas; Kaplan Samuel; Kennedy Donald; Krug Judith; Levinson Rachel; Marcus Emilie; Metzger Henry; Morse Stephen S; O'Brien Alison; Onderdonk Andrew; Poste George; Renault Beatrice; Rich Robert; Rosengard Ariella; Salzberg Steven; Scanlan Mary; Shenk Thomas; Tabor Herbert; Varmus Harold; Wimmer Eckard; Yamamoto Keith;
Statement on the consideration of biodefence and biosecurity.
Nature 2003;421(6925):771.
2003: Atlas Ronald; Campbell Philip; Cozzarelli Nicholas R; Curfman Greg; Enquist Lynn; Fink Gerald; Flanagin Annette; Fletcher Jacqueline; George Elizabeth; Hammes Gordon; Heyman David; Inglesby Thomas; Kaplan Samuel; Kennedy Donald; Krug Judith; Levinson Rachel E; Marcus Emilie; Metzger Henry; Morse Stephen S; O'Brien Alison; Onderdonk Andrew; Poste George; Renault Beatrice; Rich Robert; Rosengard Ariella; Salzburg Steven; Scanlan Mary; Shenk Thomas; Tabor Herbert; Varmus Harold; Wimmer Eckard; Yamamoto Keith;
Uncensored exchange of scientific results.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1464.
2002: Varmus Harold
Building a global culture of science.
Lancet 2002;360 Suppl():s1-4.
2002: Gilman Alfred G; Simon Melvin I; Bourne Henry R; Harris Bruce A; Long Rochelle; Ross Elliott M; Stull James T; Taussig Ronald; Bourne Henry R; Arkin Adam P; Cobb Melanie H; Cyster Jason G; Devreotes Peter N; Ferrell James E; Fruman David; Gold Michael; Weiss Arthur; Stull James T; Berridge Michael J; Cantley Lewis C; Catterall William A; Coughlin Shaun R; Olson Eric N; Smith Temple F; Brugge Joan S; Botstein David; Dixon Jack E; Hunter Tony; Lefkowitz Robert J; Pawson Anthony J; Sternberg Paul W; Varmus Harold; Subramaniam Shankar; Sinkovits Robert S; Li Joshua; Mock Dennis; Ning Yuhong; Saunders Brian; Sternweis Paul C; Hilgemann Donald; Scheuermann Richard H; DeCamp Dianne; Hsueh Robert; Lin Keng-Mean; Ni Yan; Seaman William E; Simpson Paul C; O'Connell Timothy D; Roach Tamara; Simon Melvin I; Choi Sangdun; Eversole-Cire Pamela; Fraser Iain; Mumby Marc C; Zhao Yingming; Brekken Deirdre; Shu Hongjun; Meyer Tobias; Chandy Grischa; Heo Won Do; Liou Jen; O'Rourke Nancy; Verghese Mary; Mumby Susanne M; Han Heping; Brown H Alex; Forrester Jeffrey S; Ivanova Pavlina; Milne Stephen B; Casey Patrick J; Harden T Kendall; Arkin Adam P; Doyle John; Gray Martha L; Meyer Tobias; Michnick Stephen; Schmidt Martin A; Toner Mehmet; Tsien Roger Y; Natarajan Madhusudan; Ranganathan Rama; Sambrano Gilberto R;
Overview of the Alliance for Cellular Signaling.
Nature 2002;420(6916):703-6.
2002: Varmus Harold
Getting ready for gene-based medicine.
The New England journal of medicine 2002;347(19):1526-7.
2002: Eisen Michael B; Brown Patrick O; Varmus Harold E
Public-access group supports PubMed Central.
Nature 2002;419(6903):111.
2002: Orsulic Sandra; Li Yi; Soslow Robert A; Vitale-Cross Lynn A; Gutkind J Silvio; Varmus Harold E
Induction of ovarian cancer by defined multiple genetic changes in a mouse model system.
Cancer cell 2002;1(1):53-62.
2002: Varmus Harold
The weaknesses of science for profit.
The oncologist 2002;7(1):4-5.
2001: Fisher G H; Wellen S L; Klimstra D; Lenczowski J M; Tichelaar J W; Lizak M J; Whitsett J A; Koretsky A; Varmus H E
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
Genes & development 2001;15(24):3249-62.
2001: Varmus H
How popular TV shows shape public perceptions of medical scientists.
The Mount Sinai journal of medicine, New York 2001;68(6):346-9.
2001: Lewis B C; Chinnasamy N; Morgan R A; Varmus H E
Development of an avian leukosis-sarcoma virus subgroup A pseudotyped lentiviral vector.
Journal of virology 2001;75(19):9339-44.
2001: Varmus H
A mover in the biomedical community. An interview with Harold Varmus, President of Memorial Sloan-Kettering Cancer Center in New York City and former Director of NIH by Holger Breithaupt.
EMBO reports 2001;2(5):360-2.
2001: Roberts R J; Varmus H E; Ashburner M; Brown P O; Eisen M B; Khosla C; Kirschner M; Nusse R; Scott M; Wold B
Information access. Building a "GenBank" of the published literature.
Science (New York, N.Y.) 2001;291(5512):2318-9.
2001: Varmus H
Public health. Proliferation of National Institutes of Health.
Science (New York, N.Y.) 2001;291(5510):1903-5.
2001: Xing L; Venegas A M; Chen A; Garrett-Beal L; Boyce B F; Varmus H E; Schwartzberg P L
Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival.
Genes & development 2001;15(2):241-53.
2001: Varmus H
Harold Varmus [interview by Karen Birmingham]
Nature medicine 2001;7(1):10.
2001: Chamorro M; Czar M J; Debnath J; Cheng G; Lenardo M J; Varmus H E; Schwartzberg P L
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.
BMC immunology 2001;2():3.
2001: Li Y; Podsypanina K; Liu X; Crane A; Tan L K; Parsons R; Varmus H E
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice.
BMC molecular biology 2001;2():2.
2000: Williams B O; Barish G D; Klymkowsky M W; Varmus H E
A comparative evaluation of beta-catenin and plakoglobin signaling activity.
Oncogene 2000;19(50):5720-8.
2000: Nathan D G; Varmus H E
The National Institutes of Health and clinical research: a progress report.
Nature medicine 2000;6(11):1201-4.
2000: Li Y; Hively W P; Varmus H E
Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer.
Oncogene 2000;19(8):1002-9.
2000: Varmus H E
The challenge of making laws on the shifting terrain of science.
The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2000;28(4 Suppl):46-53.
1999: Zorn A M; Barish G D; Williams B O; Lavender P; Klymkowsky M W; Varmus H E
Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin.
Molecular cell 1999;4(4):487-98.
1999: Klymkowsky M W; Williams B O; Barish G D; Varmus H E; Vourgourakis Y E
Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling.
Molecular biology of the cell 1999;10(10):3151-69.
1999: Fisher G H; Orsulic S; Holland E; Hively W P; Li Y; Lewis B C; Williams B O; Varmus H E
Development of a flexible and specific gene delivery system for production of murine tumor models.
Oncogene 1999;18(38):5253-60.
1999: Schaeffer E M; Debnath J; Yap G; McVicar D; Liao X C; Littman D R; Sher A; Varmus H E; Lenardo M J; Schwartzberg P L
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Science (New York, N.Y.) 1999;284(5414):638-41.
1999: Bocchinfuso W P; Hively W P; Couse J F; Varmus H E; Korach K S
A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha.
Cancer research 1999;59(8):1869-76.
1999: Debnath J; Chamorro M; Czar M J; Schaeffer E M; Lenardo M J; Varmus H E; Schwartzberg P L
rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases.
Molecular and cellular biology 1999;19(2):1498-507.
1998: Holland E C; Hively W P; DePinho R A; Varmus H E
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.
Genes & development 1998;12(23):3675-85.
1998: Holland E C; Hively W P; Gallo V; Varmus H E
Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes.
Genes & development 1998;12(23):3644-9.
1998: Varmus H E
National Institutes of Health in the tropics.
The American journal of tropical medicine and hygiene 1998;59(1):24-8.
1998: Gallin J I; Varmus H
Revitalization of the Warren G. Magnuson Clinical Center at the National Institutes of Health.
Academic medicine : journal of the Association of American Medical Colleges 1998;73(5):460-6.
1998: Bates P; Rong L; Varmus H E; Young J A; Crittenden L B
Genetic mapping of the cloned subgroup A avian sarcoma and leukosis virus receptor gene to the TVA locus.
Journal of virology 1998;72(3):2505-8.
1998: Holland E C; Varmus H E
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1218-23.
1997: Saint-Jeannet J P; He X; Varmus H E; Dawid I B
Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13713-8.
1997: Schwartzberg P L; Xing L; Hoffmann O; Lowell C A; Garrett L; Boyce B F; Varmus H E
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.
Genes & development 1997;11(21):2835-44.
1997: Varmus H; Satcher D
Ethical complexities of conducting research in developing countries.
The New England journal of medicine 1997;337(14):1003-5.
1997: Jones J M; Attardi L; Godley L A; Laucirica R; Medina D; Jacks T; Varmus H E; Donehower L A
Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(8):829-38.
1997: Varmus H
US support for malaria research.
Nature 1997;388(6641):416.
1997: Willert K; Brink M; Wodarz A; Varmus H; Nusse R
Casein kinase 2 associates with and phosphorylates dishevelled.
The EMBO journal 1997;16(11):3089-96.
1997: Finch P W; He X; Kelley M J; Uren A; Schaudies R P; Popescu N C; Rudikoff S; Aaronson S A; Varmus H E; Rubin J S
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6770-5.
1997: He X; Saint-Jeannet J P; Wang Y; Nathans J; Dawid I; Varmus H
A member of the Frizzled protein family mediating axis induction by Wnt-5A.
Science (New York, N.Y.) 1997;275(5306):1652-4.
1996: Chen X; Kang H; Shen L X; Chamorro M; Varmus H E; Tinoco I
A characteristic bent conformation of RNA pseudoknots promotes -1 frameshifting during translation of retroviral RNA.
Journal of molecular biology 1996;260(4):479-83.
1996: Broccoli D; Godley L A; Donehower L A; Varmus H E; de Lange T
Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.
Molecular and cellular biology 1996;16(7):3765-72.
1996: Varmus H; Paul W E
Planning of US AIDS research.
Nature 1996;381(6580):270.
1996: Godley L A; Kopp J B; Eckhaus M; Paglino J J; Owens J; Varmus H E
Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.
Genes & development 1996;10(7):836-50.
1996: Lowell C A; Niwa M; Soriano P; Varmus H E
Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis.
Blood 1996;87(5):1780-92.
1996: Leavitt A D; Robles G; Alesandro N; Varmus H E
Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection.
Journal of virology 1996;70(2):721-8.
1996: Donehower L A; Godley L A; Aldaz C M; Pyle R; Shi Y P; Pinkel D; Gray J; Bradley A; Medina D; Varmus H E
The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model.
Progress in clinical and biological research 1996;395():1-11.
1996: Varmus H
The Pastorian: a legacy of Louis Pasteur.
Advances in cancer research 1996;69():1-16.
1995: Taylor I C; Roy S; Varmus H E
Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation.
Oncogene 1995;11(12):2619-26.
1995: Varmus H
Shattuck Lecture--biomedical research enters the steady state.
The New England journal of medicine 1995;333(12):811-5.
1995: Lee S I; Umen J G; Varmus H E
A genetic screen identifies cellular factors involved in retroviral -1 frameshifting.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6587-91.
1995: Varmus H E
Harold E. Varmus, MD.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 1995;43(3):220-6.
1995: Kaplan K B; Swedlow J R; Morgan D O; Varmus H E
c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.
Genes & development 1995;9(12):1505-17.
1995: Varmus H E
An overview of the FY-1996 budget for the National Institutes of Health.
Academic medicine : journal of the Association of American Medical Colleges 1995;70(5):385-7.
1995: Ranade K; Hussussian C J; Sikorski R S; Varmus H E; Goldstein A M; Tucker M A; Serrano M; Hannon G J; Beach D; Dracopoli N C
Mutations associated with familial melanoma impair p16INK4 function.
Nature genetics 1995;10(1):114-6.
1995: He X; Saint-Jeannet J P; Woodgett J R; Varmus H E; Dawid I B
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.
Nature 1995;374(6523):617-22.
1995: Donehower L A; Godley L A; Aldaz C M; Pyle R; Shi Y P; Pinkel D; Gray J; Bradley A; Medina D; Varmus H E
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.
Genes & development 1995;9(7):882-95.
1995: Taylor I C; Roy S; Yaswen P; Stampfer M R; Varmus H E
Mouse mammary tumors express elevated levels of RNA encoding the murine homology of SKY, a putative receptor tyrosine kinase.
The Journal of biological chemistry 1995;270(12):6872-80.
1995: Chen X; Chamorro M; Lee S I; Shen L X; Hines J V; Tinoco I; Varmus H E
Structural and functional studies of retroviral RNA pseudoknots involved in ribosomal frameshifting: nucleotides at the junction of the two stems are important for efficient ribosomal frameshifting.
The EMBO journal 1995;14(4):842-52.
1995: Boeuf H; Murphy J; Bibbins K B; Varmus H E
Binding in vitro of phosphotyrosine-containing proteins to pp60c-src SH2 domain does not correlate with CEF transformation.
Oncogene 1995;10(3):433-8.
1994: Federspiel M J; Bates P; Young J A; Varmus H E; Hughes S H
A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11241-5.
1994: Müller H P; Varmus H E
DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes.
The EMBO journal 1994;13(19):4704-14.
1994: Kaplan K B; Bibbins K B; Swedlow J R; Arnaud M; Morgan D O; Varmus H E
Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.
The EMBO journal 1994;13(20):4745-56.
1994: Gilbert J M; Bates P; Varmus H E; White J M
The receptor for the subgroup A avian leukosis-sarcoma viruses binds to subgroup A but not to subgroup C envelope glycoprotein.
Journal of virology 1994;68(9):5623-8.
1994: Varmus H
Basic science and the NIH.
Molecular biology of the cell 1994;5(3):267-72.
1994: Lowell C A; Soriano P; Varmus H E
Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.
Genes & development 1994;8(4):387-98.
1994: Verderame M F; Varmus H E
Highly conserved amino acids in the SH2 and catalytic domains of v-src are altered in naturally occurring, transformation-defective alleles.
Oncogene 1994;9(1):175-82.
1994: Varmus H E; Lowell C A
Cancer genes and hematopoiesis.
Blood 1994;83(1):5-9.
1994: Varmus H E
Harold Varmus, director, National Institutes of Health. Interview by Richard Horton.
Lancet 1994;343(8888):39-40.
1994: Varmus H E; Godley L A; Roy S; Taylor I C; Yuschenkoff L; Shi Y P; Pinkel D; Gray J; Pyle R; Aldaz C M
Defining the steps in a multistep mouse model for mammary carcinogenesis.
Cold Spring Harbor symposia on quantitative biology 1994;59():491-9.
1993: Bibbins K B; Boeuf H; Varmus H E
Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides.
Molecular and cellular biology 1993;13(12):7278-87.
1993: Shackleford G M; Willert K; Wang J; Varmus H E
The Wnt-1 proto-oncogene induces changes in morphology, gene expression, and growth factor responsiveness in PC12 cells.
Neuron 1993;11(5):865-75.
1993: Parkin N T; Kitajewski J; Varmus H E
Activity of Wnt-1 as a transmembrane protein.
Genes & development 1993;7(11):2181-93.
1993: Bates P; Young J A; Varmus H E
A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor.
Cell 1993;74(6):1043-51.
1993: Shackleford G M; Shivakumar S; Shiue L; Mason J; Kenyon C; Varmus H E
Two wnt genes in Caenorhabditis elegans.
Oncogene 1993;8(7):1857-64.
1993: Young J A; Bates P; Varmus H E
Isolation of a chicken gene that confers susceptibility to infection by subgroup A avian leukosis and sarcoma viruses.
Journal of virology 1993;67(4):1811-6.
1993: Bishop J M; Kirschner M; Varmus H
Science and the new administration.
Science (New York, N.Y.) 1993;259(5094):444-5.
1993: Leavitt A D; Shiue L; Varmus H E
Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro.
The Journal of biological chemistry 1993;268(3):2113-9.
1993: Shackleford G M; MacArthur C A; Kwan H C; Varmus H E
Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):740-4.
1993: Müller H P; Pryciak P M; Varmus H E
Retroviral integration machinery as a probe for DNA structure and associated proteins.
Cold Spring Harbor symposia on quantitative biology 1993;58():533-41.
1992: Pryciak P M; Müller H P; Varmus H E
Simian virus 40 minichromosomes as targets for retroviral integration in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9237-41.
1992: Pryciak P M; Varmus H E
Fv-1 restriction and its effects on murine leukemia virus integration in vivo and in vitro.
Journal of virology 1992;66(10):5959-66.
1992: Parkin N T; Chamorro M; Varmus H E
Human immunodeficiency virus type 1 gag-pol frameshifting is dependent on downstream mRNA secondary structure: demonstration by expression in vivo.
Journal of virology 1992;66(8):5147-51.
1992: Kaplan K B; Swedlow J R; Varmus H E; Morgan D O
Association of p60c-src with endosomal membranes in mammalian fibroblasts.
The Journal of cell biology 1992;118(2):321-33.
1992: Nusse R; Varmus H E
Wnt genes.
Cell 1992;69(7):1073-87.
1992: Mason J O; Kitajewski J; Varmus H E
Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line.
Molecular biology of the cell 1992;3(5):521-33.
1992: Pryciak P M; Varmus H E
Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection.
Cell 1992;69(5):769-80.
1992: Leavitt A D; Rose R B; Varmus H E
Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae.
Journal of virology 1992;66(4):2359-68.
1992: Kitajewski J; Mason J O; Varmus H E
Interaction of Wnt-1 proteins with the binding protein BiP.
Molecular and cellular biology 1992;12(2):784-90.
1992: Jue S F; Bradley R S; Rudnicki J A; Varmus H E; Brown A M
The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.
Molecular and cellular biology 1992;12(1):321-8.
1992: Kwan H; Pecenka V; Tsukamoto A; Parslow T G; Guzman R; Lin T P; Muller W J; Lee F S; Leder P; Varmus H E
Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice.
Molecular and cellular biology 1992;12(1):147-54.
1992: Pryciak P M; Sil A; Varmus H E
Retroviral integration into minichromosomes in vitro.
The EMBO journal 1992;11(1):291-303.
1992: Chamorro M; Parkin N; Varmus H E
An RNA pseudoknot and an optimal heptameric shift site are required for highly efficient ribosomal frameshifting on a retroviral messenger RNA.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):713-7.
1991: Basu S; Varmus H E
Retraction. Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites.
Journal of virology 1991;65(12):7086.
1991: Seeger C; Baldwin B; Hornbuckle W E; Yeager A E; Tennant B C; Cote P; Ferrell L; Ganem D; Varmus H E
Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host.
Journal of virology 1991;65(4):1673-9.
1991: Nusse R; Brown A; Papkoff J; Scambler P; Shackleford G; McMahon A; Moon R; Varmus H
A new nomenclature for int-1 and related genes: the Wnt gene family.
Cell 1991;64(2):231.
1991: Morgan D O; Kaplan J M; Bishop J M; Varmus H E
Production of p60c-src by baculovirus expression and immunoaffinity purification.
Methods in enzymology 1991;200():645-60.
1990: Young J A; Bates P; Willert K; Varmus H E
Efficient incorporation of human CD4 protein into avian leukosis virus particles.
Science (New York, N.Y.) 1990;250(4986):1421-3.
1990: Hirai H; Varmus H E
SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src.
Genes & development 1990;4(12B):2342-52.
1990: Basu S; Varmus H E
Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites.
Journal of virology 1990;64(11):5617-25.
1990: Hirai H; Varmus H E
Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8592-6.
1990: Chang L J; Hirsch R C; Ganem D; Varmus H E
Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase.
Journal of virology 1990;64(11):5553-8.
1990: Varmus H E
Nobel lecture. Retroviruses and oncogenes. I.
Bioscience reports 1990;10(5):413-30.
1990: Chang L J; Ganem D; Varmus H E
Mechanism of translation of the hepadnaviral polymerase (P) gene.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):5158-62.
1990: Hirai H; Varmus H E
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.
Molecular and cellular biology 1990;10(4):1307-18.
1990: Hirsch R C; Lavine J E; Chang L J; Varmus H E; Ganem D
Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription.
Nature 1990;344(6266):552-5.
1990: Kaplan J M; Varmus H E; Bishop J M
The src protein contains multiple domains for specific attachment to membranes.
Molecular and cellular biology 1990;10(3):1000-9.
1990: de Lange T; Shiue L; Myers R M; Cox D R; Naylor S L; Killery A M; Varmus H E
Structure and variability of human chromosome ends.
Molecular and cellular biology 1990;10(2):518-27.
1989: Chang L J; Dienstag J; Ganem D; Varmus H
Detection of antibodies against hepatitis B virus polymerase antigen in hepatitis B virus-infected patients.
Hepatology (Baltimore, Md.) 1989;10(3):332-5.
1989: Kamb A; Weir M; Rudy B; Varmus H; Kenyon C
Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4372-6.
1989: Morgan D O; Kaplan J M; Bishop J M; Varmus H E
Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase.
Cell 1989;57(5):775-86.
1989: Bowerman B; Brown P O; Bishop J M; Varmus H E
A nucleoprotein complex mediates the integration of retroviral DNA.
Genes & development 1989;3(4):469-78.
1989: Brown P O; Bowerman B; Varmus H E; Bishop J M
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2525-9.
1989: Varmus H E
Reverse transcription in bacteria.
Cell 1989;56(5):721-4.
1989: Chang L J; Pryciak P; Ganem D; Varmus H E
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting.
Nature 1989;337(6205):364-8.
1989: Verderame M F; Kaplan J M; Varmus H E
A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner.
Journal of virology 1989;63(1):338-48.
1989: Varmus H
Transgenic mice and host cell mutants resistant to transformation as model systems for identifying multiple components in oncogenesis.
Ciba Foundation symposium 1989;142():20-6; discussion 26-35.
1989: Varmus H; Hirai H; Morgan D; Kaplan J; Bishop J M
Function, location, and regulation of the src protein-tyrosine kinase.
Princess Takamatsu symposia 1989;20():63-70.
1988: Shackleford G M; Varmus H E
Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9655-9.
1988: Tsukamoto A S; Grosschedl R; Guzman R C; Parslow T; Varmus H E
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice.
Cell 1988;55(4):619-25.
1988: Jacks T; Madhani H D; Masiarz F R; Varmus H E
Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region.
Cell 1988;55(3):447-58.
1988: Varmus H
Regulation of HIV and HTLV gene expression.
Genes & development 1988;2(9):1055-62.
1988: Varmus H
Retroviruses.
Science (New York, N.Y.) 1988;240(4858):1427-35.
1988: Kaplan J M; Mardon G; Bishop J M; Varmus H E
The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant.
Molecular and cellular biology 1988;8(6):2435-41.
1988: Jacks T; Power M D; Masiarz F R; Luciw P A; Barr P J; Varmus H E
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression.
Nature 1988;331(6153):280-3.
1987: Varmus H E
Oncogenes and transcriptional control.
Science (New York, N.Y.) 1987;238(4832):1337-9.
1987: Papkoff J; Brown A M; Varmus H E
The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway.
Molecular and cellular biology 1987;7(11):3978-84.
1987: Brown A M; Papkoff J; Fung Y K; Shackleford G M; Varmus H E
Identification of protein products encoded by the proto-oncogene int-1.
Molecular and cellular biology 1987;7(11):3971-7.
1987: Chang C; Enders G; Sprengel R; Peters N; Varmus H E; Ganem D
Expression of the precore region of an avian hepatitis B virus is not required for viral replication.
Journal of virology 1987;61(10):3322-5.
1987: Seeger C; Marion P L; Ganem D; Varmus H E
In vitro recombinants of ground squirrel and woodchuck hepatitis viral DNAs produce infectious virus in squirrels.
Journal of virology 1987;61(10):3241-7.
1987: Varmus H
Reverse transcription.
Scientific American 1987;257(3):56-9, 62-4.
1987: Sprengel R; Varmus H E; Ganem D
Homologous recombination between hepadnaviral genomes following in vivo DNA transfection: implications for studies of viral infectivity.
Virology 1987;159(2):454-6.
1987: Shackleford G M; Varmus H E
Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos.
Cell 1987;50(1):89-95.
1987: Quintrell N; Lebo R; Varmus H; Bishop J M; Pettenati M J; Le Beau M M; Diaz M O; Rowley J D
Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.
Molecular and cellular biology 1987;7(6):2267-75.
1987: Jacks T; Townsley K; Varmus H E; Majors J
Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(12):4298-302.
1987: Nottenburg C; Stubblefield E; Varmus H E
An aberrant avian leukosis virus provirus inserted downstream from the chicken c-myc coding sequence in a bursal lymphoma results from intrachromosomal recombination between two proviruses and deletion of cellular DNA.
Journal of virology 1987;61(6):1828-33.
1987: Hagino-Yamagishi K; Donehower L A; Varmus H E
Retroviral DNA integrated during infection by an integration-deficient mutant of murine leukemia virus is oligomeric.
Journal of virology 1987;61(6):1964-71.
1987: Persing D H; Varmus H E; Ganem D
The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid.
Journal of virology 1987;61(5):1672-7.
1987: Stone J; de Lange T; Ramsay G; Jakobovits E; Bishop J M; Varmus H; Lee W
Definition of regions in human c-myc that are involved in transformation and nuclear localization.
Molecular and cellular biology 1987;7(5):1697-709.
1987: Brown P O; Bowerman B; Varmus H E; Bishop J M
Correct integration of retroviral DNA in vitro.
Cell 1987;49(3):347-56.
1987: Enders G H; Ganem D; Varmus H E
5'-terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles.
Journal of virology 1987;61(1):35-41.
1987: Varmus H
Lessons from the life cycle of retroviruses.
Harvey lectures 1987;83():35-56.
1987: Ganem D; Varmus H E
The molecular biology of the hepatitis B viruses.
Annual review of biochemistry 1987;56():651-93.
1986: Persing D H; Varmus H E; Ganem D
Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide.
Science (New York, N.Y.) 1986;234(4782):1388-91.
1986: Jakobovits A; Shackleford G M; Varmus H E; Martin G R
Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(20):7806-10.
1986: Persing D H; Varmus H E; Ganem D
Antibodies to pre-S and X determinants arise during natural infection with ground squirrel hepatitis virus.
Journal of virology 1986;60(1):177-84.
1986: Brown A M; Wildin R S; Prendergast T J; Varmus H E
A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line.
Cell 1986;46(7):1001-9.
1986: Nottenburg C; Varmus H E
Features of the chicken c-myc gene that influence the structure of c-myc RNA in normal cells and bursal lymphomas.
Molecular and cellular biology 1986;6(8):2800-6.
1986: Schwab M; Klempnauer K H; Alitalo K; Varmus H; Bishop M
Rearrangement at the 5' end of amplified c-myc in human COLO 320 cells is associated with abnormal transcription.
Molecular and cellular biology 1986;6(7):2752-5.
1986: Seeger C; Ganem D; Varmus H E
Biochemical and genetic evidence for the hepatitis B virus replication strategy.
Science (New York, N.Y.) 1986;232(4749):477-84.
1986: Westaway D; Papkoff J; Moscovici C; Varmus H E
Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript.
The EMBO journal 1986;5(2):301-9.
1986: Varmus H; Bishop J M
Biochemical mechanisms of oncogene activity: proteins encoded by oncogenes. Introduction.
Cancer surveys 1986;5(2):153-8.
1986: Varmus H; Brown A; Papkoff J; Shackleford G
The int-1 proto-oncogene.
Princess Takamatsu symposia 1986;17():31-41.
1985: Lee W M; Schwab M; Westaway D; Varmus H E
Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene.
Molecular and cellular biology 1985;5(12):3345-56.
1985: Fung Y K; Shackleford G M; Brown A M; Sanders G S; Varmus H E
Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene.
Molecular and cellular biology 1985;5(12):3337-44.
1985: Jacks T; Varmus H E
Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting.
Science (New York, N.Y.) 1985;230(4731):1237-42.
1985: Enders G H; Ganem D; Varmus H
Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant.
Cell 1985;42(1):297-308.
1985: Schwab M; Varmus H E; Bishop J M
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture.
Nature 1985;316(6024):160-2.
1985: Trueba D; Phelan M; Nelson J; Beck F; Pecha B S; Brown R J; Varmus H E; Ganem D
Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts.
Hepatology (Baltimore, Md.) 1985;5(3):435-9.
1985: Schwab M; Ramsay G; Alitalo K; Varmus H E; Bishop J M; Martinsson T; Levan G; Levan A
Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells.
Nature 1985;315(6017):345-7.
1985: Persing D H; Varmus H E; Ganem D
A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(10):3440-4.
1985: Varmus H E
Viruses, genes, and cancer. I. The discovery of cellular oncogenes and their role in neoplasia.
Cancer 1985;55(10):2324-8.
1985: Varmus H E
Reverse transcriptase rides again.
Nature 1985;314(6012):583-4.
1985: Parker R C; Mardon G; Lebo R V; Varmus H E; Bishop J M
Isolation of duplicated human c-src genes located on chromosomes 1 and 20.
Molecular and cellular biology 1985;5(4):831-8.
1985: Mossie K G; Young M W; Varmus H E
Extrachromosomal DNA forms of copia-like transposable elements, F elements and middle repetitive DNA sequences in Drosophila melanogaster. Variation in cultured cells and embryos.
Journal of molecular biology 1985;182(1):31-43.
1985: Lin C C; Alitalo K; Schwab M; George D; Varmus H E; Bishop J M
Evolution of karyotypic abnormalities and C-MYC oncogene amplification in human colonic carcinoma cell lines.
Chromosoma 1985;92(1):11-5.
1985: Brodeur G M; Seeger R C; Schwab M; Varmus H E; Bishop J M
Amplification of N-myc sequences in primary human neuroblastomas: correlation with advanced disease stage.
Progress in clinical and biological research 1985;175():105-13.
1984: Donehower L A; Varmus H E
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(20):6461-5.
1984: Jakobovits E B; Majors J E; Varmus H E
Hormonal regulation of the Rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation.
Cell 1984;38(3):757-65.
1984: Seeger C; Ganem D; Varmus H E
The cloned genome of ground squirrel hepatitis virus is infectious in the animal.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(18):5849-52.
1984: Schwab M; Ellison J; Busch M; Rosenau W; Varmus H E; Bishop J M
Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(15):4940-4.
1984: Seeger C; Ganem D; Varmus H E
Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus.
Journal of virology 1984;51(2):367-75.
1984: Luciw P A; Oppermann H; Bishop J M; Varmus H E
Integration and expression of several molecular forms of Rous sarcoma virus DNA used for transfection of mouse cells.
Molecular and cellular biology 1984;4(7):1260-9.
1984: Brodeur G M; Seeger R C; Schwab M; Varmus H E; Bishop J M
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.
Science (New York, N.Y.) 1984;224(4653):1121-4.
1984: Parker R C; Varmus H E; Bishop J M
Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src.
Cell 1984;37(1):131-9.
1984: Standring D N; Rutter W J; Varmus H E; Ganem D
Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region.
Journal of virology 1984;50(2):563-71.
1984: Schwab M; Varmus H E; Bishop J M; Grzeschik K H; Naylor S L; Sakaguchi A Y; Brodeur G; Trent J
Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc.
Nature 1984;308(5956):288-91.
1984: Westaway D; Payne G; Varmus H E
Proviral deletions and oncogene base-substitutions in insertionally mutagenized c-myc alleles may contribute to the progression of avian bursal tumors.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(3):843-7.
1984: Nusse R; van Ooyen A; Cox D; Fung Y K; Varmus H
Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15.
Nature 1984;307(5947):131-6.
1984: Varmus H E
The molecular genetics of cellular oncogenes.
Annual review of genetics 1984;18():553-612.
1983: Weiser B; Ganem D; Seeger C; Varmus H E
Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus.
Journal of virology 1983;48(1):1-9.
1983: Majors J; Varmus H E
A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(19):5866-70.
1983: Schwab M; Alitalo K; Klempnauer K H; Varmus H E; Bishop J M; Gilbert F; Brodeur G; Goldstein M; Trent J
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Nature 1983;305(5931):245-8.
1983: Majors J E; Varmus H E
Nucleotide sequencing of an apparent proviral copy of env mRNA defines determinants of expression of the mouse mammary tumor virus env gene.
Journal of virology 1983;47(3):495-504.
1983: Luciw P A; Bishop J M; Varmus H E; Capecchi M R
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA.
Cell 1983;33(3):705-16.
1983: Schwab M; Alitalo K; Varmus H E; Bishop J M; George D
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells.
Nature 1983;303(5917):497-501.
1983: Swanstrom R; Parker R C; Varmus H E; Bishop J M
Transduction of a cellular oncogene: the genesis of Rous sarcoma virus.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(9):2519-23.
1983: Alitalo K; Schwab M; Lin C C; Varmus H E; Bishop J M
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(6):1707-11.
1983: Mardon G; Varmus H E
Frameshift and intragenic suppressor mutations in a Rous sarcoma provirus suggest src encodes two proteins.
Cell 1983;32(3):871-9.
1983: Czernilofsky A P; Levinson A D; Varmus H E; Bishop J M; Tischer E; Goodman H
Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus.
Nature 1983;301(5902):736-8.
1983: Varmus H E
Using retroviruses as insertional mutagens to identify cellular oncogenes.
Progress in clinical and biological research 1983;119():23-35.
1982: Nusse R; Varmus H E
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.
Cell 1982;31(1):99-109.
1982: Ganem D; Weiser B; Barchuk A; Brown R J; Varmus H E
Biological characterization of acute infection with ground squirrel hepatitis virus.
Journal of virology 1982;44(1):366-73.
1982: Ganem D; Greenbaum L; Varmus H E
Virion DNA of ground squirrel hepatitis virus: structural analysis and molecular cloning.
Journal of virology 1982;44(1):374-83.
1982: Varmus H E
A growing role for reverse transcription.
Nature 1982;299(5880):204-5.
1982: Varmus H E
Form and function of retroviral proviruses.
Science (New York, N.Y.) 1982;216(4548):812-20.
1982: Swanstrom R; Bishop J M; Varmus H E
Structure of a replication intermediate in the synthesis of Rous sarcoma virus DNA in vivo.
Journal of virology 1982;42(1):337-41.
1982: Swanstrom R; Varmus H E; Bishop J M
Nucleotide sequence of the 5' noncoding region and part of the gag gene of Rous sarcoma virus.
Journal of virology 1982;41(2):535-41.
1982: Hackett P B; Swanstrom R; Varmus H E; Bishop J M
The leader sequence of the subgenomic mRNA's of Rous sarcoma virus is approximately 390 nucleotides.
Journal of virology 1982;41(2):527-34.
1982: Payne G S; Bishop J M; Varmus H E
Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas.
Nature 1982;295(5846):209-14.
1981: Coffin J M; Varmus H E; Bishop J M; Essex M; Hardy W D; Martin G S; Rosenberg N E; Scolnick E M; Weinberg R A; Vogt P K
Proposal for naming host cell-derived inserts in retrovirus genomes.
Journal of virology 1981;40(3):953-7.
1981: Robertson D L; Varmus H E
Dexamethasone induction of the intracellular RNAs of mouse mammary tumor virus.
Journal of virology 1981;40(3):673-82.
1981: Ross N L; DeLorbe W; Varmus H E; Bishop J M; Brahic M; Haase A
Persistence and expression of Marek's disease virus DNA in tumour cells and peripheral nerves studied by in situ hybridization.
The Journal of general virology 1981;57(Pt 2):285-96.
1981: Baker B; Robison H; Varmus H E; Bishop J M
Analysis of endogenous avian retrovirus DNA and RNA: viral and cellular determinants of retrovirus gene expression.
Virology 1981;114(1):8-22.
1981: Parker R C; Varmus H E; Bishop J M
Cellular homologue (c-src) of the transforming gene of Rous sarcoma virus: isolation, mapping, and transcriptional analysis of c-src and flanking regions.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(9):5842-6.
1981: Oppermann H; Levinson A D; Levintow L; Varmus H E; Bishop J M; Kawai S
Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus.
Virology 1981;113(2):736-51.
1981: Hughes S H; Mutschler A; Bishop J M; Varmus H E
A Rous sarcoma virus provirus is flanked by short direct repeats of a cellular DNA sequence present in only one copy prior to integration.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4299-303.
1981: Dudley J P; Varmus H E
Purification and translation of murine mammary tumor virus mRNA's.
Journal of virology 1981;39(1):207-18.
1981: Varmus H E; Quintrell N; Ortiz S
Retroviruses as mutagens: insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus.
Cell 1981;25(1):23-36.
1981: Hackett P B; Varmus H E; Bishop J M
Repair of lesions which cause premature termination of transcription in chicken embryo cells irradiated with ultraviolet light.
Virology 1981;112(2):752-6.
1981: Hackett P B; Varmus H E; Bishop J M
The genesis of Rous sarcoma virus messenger RNAs.
Virology 1981;112(2):714-28.
1981: Weiss S R; Varmus H E; Bishop J M
Cell-free translation of purified avian sarcoma virus src mRNA.
Virology 1981;110(2):476-8.
1981: Cleveland D W; Hughes S H; Stubblefield E; Kirschner M W; Varmus H E
Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families.
The Journal of biological chemistry 1981;256(6):3130-4.
1981: Payne G S; Courtneidge S A; Crittenden L B; Fadly A M; Bishop J M; Varmus H E
Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state.
Cell 1981;23(2):311-22.
1981: Swanstrom R; Varmus H E; Bishop J M
The terminal redundancy of the retrovirus genome facilitates chain elongation by reverse transcriptase.
The Journal of biological chemistry 1981;256(3):1115-21.
1981: Oppermann H; Levinson A D; Varmus H E
The structure and protein kinase activity of proteins encoded by nonconditional mutants and back mutants in the sec gene of avian sarcoma virus.
Virology 1981;108(1):47-70.
1981: Hughes S H; Vogt P K; Bishop J M; Varmus H E
Endogenous proviruses of random-bred chickens and ring-necked pheasants: analysis with restriction endonucleases.
Virology 1981;108(1):222-9.
1981: Hughes S H; Vogt P K; Stubblefield E; Bishop J M; Varmus H E
Integration of avian sarcoma virus DNA in chicken cells.
Virology 1981;108(1):208-21.
1981: Hughes S H; Toyoshima K; Bishop J M; Varmus H E
Organization of the endogenous proviruses of chickens: implications for origin and expression.
Virology 1981;108(1):189-207.
1981: Shank P R; Hughes S H; Varmus H E
Restriction endonuclease mapping of the DNA of Rous-associated virus O reveals extensive homology in structure and sequence with avian sarcoma virus DNA.
Virology 1981;108(1):177-88.
1981: Swanstrom R; DeLorbe W J; Bishop J M; Varmus H E
Nucleotide sequence of cloned unintegrated avian sarcoma virus DNA: viral DNA contains direct and inverted repeats similar to those in transposable elements.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(1):124-8.
1981: Kung H J; Fung Y K; Majors J E; Bishop J M; Varmus H E
Synthesis of plus strands of retroviral DNA in cells infected with avian sarcoma virus and mouse mammary tumor virus.
Journal of virology 1981;37(1):127-38.
1981: Majors J E; Varmus H E
Nucleotide sequences at host-proviral junctions for mouse mammary tumour virus.
Nature 1981;289(5795):253-8.
1981: Varmus H E; Quintrell N; Wyke J
Revertants of an ASV-transformed rat cell line have lost the complete provius or sustained mutations in src.
Virology 1981;108(1):28-46.
1981: Majors J E; Swanstrom R; DeLorbe W J; Payne G S; Hughes S H; Ortiz S; Quintrell N; Bishop J M; Varmus H E
DNA intermediates in the replication of retroviruses are structurally (and perhaps functionally) related to transposable elements.
Cold Spring Harbor symposia on quantitative biology 1981;45 Pt 2():731-8.
1980: Levinson A D; Oppermann H; Varmus H E; Bishop J M
The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine.
The Journal of biological chemistry 1980;255(24):11973-80.
1980: Quintrell N; Hughes S H; Varmus H E; Bishop J M
Structure of viral DNA and RNA in mammalian cells infected with avian sarcoma virus.
Journal of molecular biology 1980;143(4):363-93.
1980: DeLorbe W J; Luciw P A; Goodman H M; Varmus H E; Bishop J M
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules.
Journal of virology 1980;36(1):50-61.
1980: Czernilofsky A P; Levinson A D; Varmus H E; Bishop J M; Tischer E; Goodman H M
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product.
Nature 1980;287(5779):198-203.
1980: Sheiness D K; Hughes S H; Varmus H E; Stubblefield E; Bishop J M
The vertebrate homolog of the putative transforming gene of avian myelocytomatosis virus: characteristics of the DNA locus and its RNA transcript.
Virology 1980;105(2):415-24.
1980: Cohen J C; Varmus H E
Proviruses of mouse mammary tumor virus in normal and neoplastic tissues from GR and C3Hf mouse strains.
Journal of virology 1980;35(2):298-305.
1980: Hughes S H; Stubblefield E; Nazarian K; Varmus H E
DNA of a chicken herpesvirus is associated with at least two chromosomes in a chicken lymphoblastoid cell line.
Virology 1980;105(1):234-40.
1980: Czernilofsky A P; DeLorbe W; Swanstrom R; Varmus H E; Bishop J M; Tischer E; Goodman H M
The nucleotide sequence of an untranslated but conserved domain at the 3' end of the avian sarcoma virus genome.
Nucleic acids research 1980;8(13):2967-84.
1980: Kung H J; Shank P R; Bishop J M; Varmus H E
Identification and characterization of dimeric and trimeric circular forms of avian sarcoma virus-specific DNA.
Virology 1980;103(2):425-33.
1980: Varmus H E; Cohen J C; Hughes S H; Majors J; Bishop J M
The origin and structure of endogenous retroviral DNA.
Annals of the New York Academy of Sciences 1980;354():379-83.
1980: Bishop J M; Courtneidge S A; Levinson A D; Oppermann H; Quintrell N; Sheiness D K; Weiss S R; Varmus H E
Origin and function of avian retrovirus transforming genes.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 2,():919-30.
1980: Hughes S H; Vogt P K; Stubblefield E; Robinson H; Bishop J M; Varmus H E
Organization of endogenous and exogenous viral and linked nonviral sequences.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 2,():1077-89.
1980: Wyke J A; Beamand J A; Varmus H E
Factors affecting phenotypic reversion of rat cells transformed by avian sarcoma virus.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 2,():1065-75.
1979: Hughes S H; Robinson H L; Bishop J M; Varmus H E
The replication of subgroup E avian retroviruses is blocked at or before viral DNA synthesis in restrictive chicken cells.
Virology 1979;99(2):437-42.
1979: Cohen J C; Majors J E; Varmus H E
Organization of mouse mammary tumor virus-specific DNA endogenous to BALB/c mice.
Journal of virology 1979;32(2):483-96.
1979: Hughes S H; Payvar F; Spector D; Schimke R T; Robinson H L; Payne G S; Bishop J M; Varmus H E
Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases.
Cell 1979;18(2):347-59.
1979: Lee J S; Varmus H E; Bishop J M
Virus-specific messenger RNAs in permissive cells infected by avian sarcoma virus.
The Journal of biological chemistry 1979;254(16):8015-22.
1979: Martin G S; Radke K; Hughes S; Quintrell N; Bishop J M; Varmus H E
Mutants of Rous sarcoma virus with extensive deletions of the viral genome.
Virology 1979;96(2):530-46.
1979: Robertson D L; Varmus H E
Structural analysis of the intracellular RNAs of murine mammary tumor virus.
Journal of virology 1979;30(2):576-89.
1979: Oppermann H; Levinson A D; Varmus H E; Levintow L; Bishop J M
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src).
Proceedings of the National Academy of Sciences of the United States of America 1979;76(4):1804-8.
1979: Hughes S H; Stubblefield E; Payvar F; Engel J D; Dodgson J B; Spector D; Cordell B; Schimke R T; Varmus H E
Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(3):1348-52.
1979: Cohen J C; Varmus H E
Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding.
Nature 1979;278(5703):418-23.
1979: Cohen J C; Shank P R; Morris V L; Cardiff R; Varmus H E
Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse.
Cell 1979;16(2):333-45.
1979: Ringold G M; Shank P R; Varmus H E; Ring J; Yamamoto K R
Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(2):665-9.
1979: Morris V L; Kozak C; Cohen J C; Shank P R; Jolicoeur P; Ruddle F; Varmus H E
Endogenous mouse mammary tumor virus DNA is distributed among multiple mouse chromosomes.
Virology 1979;92(1):46-55.
1979: Varmus H E; Shank P R; Hughes S H; Kung H J; Heasley S; Majors J; Vogt P K; Bishop J M
Structures of unintegrated and integrated forms of the deoxyribonucleic acid of ribonucleic acid tumour viruses.
Biochemical Society symposium 1979;44():103-18.
1979: Varmus H E; Ringold G; Yamamoto K R
Regulation of mouse mammary tumor virus gene expression by glucocorticoid hormones.
Monographs on endocrinology 1979;12():253-78.
1979: Varmus H E; Shank P R; Hughes S E; Kung H J; Heasley S; Majors J; Vogt P K; Bishop J M
Synthesis, structure, and integration of the DNA of RNA tumor viruses.
Cold Spring Harbor symposia on quantitative biology 1979;43 Pt 2():851-64.
1978: Hughes S H; Shank P R; Spector D H; Kung H J; Bishop J M; Varmus H E; Vogt P K; Breitman M L
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites.
Cell 1978;15(4):1397-410.
1978: Shank P R; Hughes S H; Kung H J; Majors J E; Quintrell N; Guntaka R V; Bishop J M; Varmus H E
Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA.
Cell 1978;15(4):1383-95.
1978: Levinson A D; Oppermann H; Levintow L; Varmus H E; Bishop J M
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein.
Cell 1978;15(2):561-72.
1978: Spector D H; Varmus H E; Bishop J M
Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(9):4102-6.
1978: Fujita D J; Tal J; Varmus H E; Bishop J M
env Gene of chicken RNA tumor viruses: extent of conservation in cellular and viral genomes.
Journal of virology 1978;27(3):465-74.
1978: Cordell B; Weiss S R; Varmus H E; Bishop J M
At least 104 nucleotides are transposed from the 5' terminus of the avian sarcoma virus genome to the 5' termini of smaller viral mRNAs.
Cell 1978;15(1):79-91.
1978: Bishop J M; Baker B; Fujita D; McCombe P; Sheiness D; Smith K; Spector D H; Stehelin D; Varmus H E
Genesis of a virus-transforming gene.
National Cancer Institute monograph 1978;(48):219-23.
1978: Shank P R; Cohen J C; Varmus H E; Yamamoto K R; Ringold G M
Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: evidence for a large specific deletion occurring at high frequency during circularization.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(5):2112-6.
1978: Ringold G M; Cohen J C; Ring J; Shank P R; Varmus H E; Yamamoto K R
Mouse mammary tumor virus genes: regulation of expression by glucocorticoids and structural analysis with restriction endonucleases.
Journal of toxicology and environmental health 1978;4(2-3):457-70.
1978: Varmus H E; Heasley S; Kung H J; Oppermann H; Smith V C; Bishop J M; Shank P R
Kinetics of synthesis, structure and purification of avian sarcoma virus-specific DNA made in the cytoplasm of acutely infected cells.
Journal of molecular biology 1978;120(1):55-82.
1978: Spector D H; Baker B; Varmus H E; Bishop J M
Characteristics of cellular RNA related to the transforming gene of avian sarcoma viruses.
Cell 1978;13(2):381-6.
1978: Spector D H; Smith K; Padgett T; McCombe P; Roulland-Dussoix D; Moscovici C; Varmus H E; Bishop J M
Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses.
Cell 1978;13(2):371-9.
1978: Shank P R; Varmus H E
Virus-specific DNA in the cytoplasm of avian sarcoma virus-infected cells is a precursor to covalently closed circular viral DNA in the nucleus.
Journal of virology 1978;25(1):104-4.
1977: Weiss S R; Varmus H E; Bishop J M
The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses.
Cell 1977;12(4):983-92.
1977: Oppermann H; Bishop J M; Varmus H E; Levintow L
A joint produce of the genes gag and pol of avian sarcoma virus: a possible precursor of reverse transcriptase.
Cell 1977;12(4):993-1005.
1977: Morris V L; Medeiros E; Ringold G M; Bishop J M; Varmus H E
Comparison of mouse mammary tumor virus-specific DNA in inbred, wild and Asian mice, and in tumors and normal organs from inbred mice.
Journal of molecular biology 1977;114(1):73-91.
1977: Ringold G M; Yamamoto K R; Bishop J M; Varmus H E
Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(7):2879-83.
1977: Varmus H E; Padgett T; Heasley S; Simon G; Bishop J M
Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA.
Cell 1977;11(2):307-19.
1977: Friedrich R; Kung H J; Baker B; Varmus H E; Goodman H M; Bishop J M
Characterization of DNA complementary to nucleotide sequences at the 5'-terminus of the avian sarcoma virus genome.
Virology 1977;79(1):198-215.
1977: Tal J; Kung H J; Varmus H E; Bishop J M
Characterization of DNA complementary to nucleotide sequences adjacent to poly(A) at the 3'-terminus of the avian sarcoma virus genome.
Virology 1977;79(1):183-97.
1977: Padgett T G; Stubbledield E; Varmus H E
Chicken macrochromosomes contain an endogenous provirus and microchromosomes contain sequences related to the transforming gene of ASV.
Cell 1977;10(4):649-57.
1977: Bister K; Varmus H E; Stavnezer E; Hunter E; Vogt P K
Biological and biochemical studies on the inactivation of avian oncoviruses by ultraviolet irradiation.
Virology 1977;77(2):689-704.
1977: Stehelin D; Fujita D J; Padgett T; Varmus H E; Bishop J M
Detection and enumeration of transformation-defective strains of avian sarcoma virus with molecular hybridization.
Virology 1977;76(2):675-84.
1977: Tal J; Fujita D J; Kawai S; Varmus H E; Bishop J M
Purification of DNA complementary to the env gene of avian sarcoma virus and analysis of relationships among the env genes of avian leukosis-sarcoma viruses.
Journal of virology 1977;21(2):497-505.
1977: Ringold G M; Yamamoto K R; Shank P R; Varmus H E
Mouse mammary tumor virus DNA in infected rat cells: characterization of unintegrated forms.
Cell 1977;10(1):19-26.
1977: Ringold G M; Cardiff R D; Varmus H E; Yamamoto K R
Infection of cultured rat hepatoma cells by mouse mammary tumor virus.
Cell 1977;10(1):11-8.
1977: Deng C T; Stehelin D; Bishop J M; Varmus H E
Characteristics of virus-specific RNA in avian sarcoma virus-transformed BHK-21 cells and revertants.
Virology 1977;76(1):313-30.
1976: Stavnezer E; Ringold G; Varmus H E; Bishop J M
RNA complementary to the genome of RNA tumor viruses in virions and virus-producing cells.
Journal of virology 1976;20(1):342-7.
1976: Verma I M; Varmus H E; Hunter E
Characterization of "early" temperature-sensitive mutants of avian sarcoma viruses: biological properties, thermolability of reverse transcriptase in vitro, and synthesis of viral DNA in infected cells.
Virology 1976;74(1):16-29.
1976: Friedrich R; Morris V L; Goodman H M; Bishop J M; Varmus H E
Differences between genomes of two strains of mouse mammary tumor virus as shown by partial RNA sequence analysis.
Virology 1976;72(2):330-40.
1976: Varmus H E; Heasley S; Linn J; Wheeler K
Use of alkaline sucrose gradients in a zonal rotor to detect integrated and unintegrated avian sarcoma virus-specific DNA in cells.
Journal of virology 1976;18(2):574-85.
1976: Varmus H E; Shank P R
Unintegrated viral DNA is synthesized in the cytoplasm of avian sarcoma virus-transformed duck cells by viral DNA polymerase.
Journal of virology 1976;18(2):567-73.
1976: Ringold G M; Blair P B; Bishop J M; Varmus H E
Nucleotide sequence homologies among mouse mammary tumor viruses.
Virology 1976;70(2):550-3.
1976: Stehelin D; Varmus H E; Bishop J M; Vogt P K
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.
Nature 1976;260(5547):170-3.
1976: Stehelin D; Guntaka R V; Varmus H E; Bishop J M
Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses.
Journal of molecular biology 1976;101(3):349-65.
1975: Ringold G M; Yamamoto K R; Tomkins G M; Bishop M; Varmus H E
Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action.
Cell 1975;6(3):299-305.
1975: Stehelin D; Varmus H E; Bishop J M
Detection of nucleotide sequences associated with transformation by avian sarcoma viruses.
Bibliotheca haematologica 1975;(43):539-41.
1975: Ringold G; Lasfargues E Y; Bishop J M; Varmus H E
Production of mouse mammary tumor virus by cultured cells in the absence and presence of hormones: assay by molecular hybridization.
Virology 1975;65(1):135-47.
1975: Guntaka R V; Mahy B W; Bishop J M; Varmus H E
Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus.
Nature 1975;253(5492):507-11.
1975: Bishop J M; Deng C T; Faras A J; Goodman H M; Guntaka R R; Levinson W E; Cordell-Stewart B; Taylor J M; Varmus H E
Transcription of the Rous sarcoma virus genome in vitro and in vivo.
Bibliotheca haematologica 1975;(40):517-23.
1975: Varmus H E; Stavnezer J; Medeiros E; Bishop J M
Detection and characterization of RNA tumor virus-specific DNA in cells.
Bibliotheca haematologica 1975;(40):451-61.
1975: Varmus H E; Guntaka R V; Deng C T; Bishop J M
Synthesis, structure and function of avian sarcoma virus-specific DNA in permissive and nonpermissive cells.
Cold Spring Harbor symposia on quantitative biology 1975;39 Pt 2():987-96.
1974: Deng C T; Boettiger D; Macpherson I; Varmus H E
The persistence and expression of virus-specific DNA in revertants of Rous sarcoma virus-transformed BHK-21 cells.
Virology 1974;62(2):512-21.
1974: Varmus H E; Guntaka R V; Fan W J; Heasley S; Bishop J M
Synthesis of viral DNA in the cytoplasm of duck embryo fibroblasts and in enucleated cells after infection by avian sarcoma virus.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(10):3874-8.
1974: Bishop J M; Quintrell N; Medeiros E; Varmus H E
Of birds and mice and men: comments on the use of animal models and molecular hybridization in the search for human tumor viruses.
Cancer 1974;34(4 Suppl):suppl:1421-6.
1974: Varmus H E; Heasley S; Bishop J M
Use of DNA-DNA annealing to detect new virus-specific DNA sequences in chicken embryo fibroblasts after infection by avian sarcoma virus.
Journal of virology 1974;14(4):895-903.
1974: Levy J A; Kazan P M; Varmus H E
The importance of DNA size for successful transfection of chicken embryo fibroblasts.
Virology 1974;61(1):297-302.
1974: Quintrell N; Varmus H E; Bishop J M; Nicholson M O; McAllister R M
Homologies among the nucleotide sequences of the genomes of C-type viruses.
Virology 1974;58(2):568-75.
1974: Taylor J M; Varmus H E; Faras A J; Levinson W E; Bishop J M
Letter: Evidence for non-repetitive subunits in the genome of Rous sarcoma virus.
Journal of molecular biology 1974;84(1):217-21.
1974: Haase A T; Garapin A C; Faras A J; Varmus H E; Bishop J M
Characterization of the nucleic acid product of the visna virus RNA dependent DNA polymerase.
Virology 1974;57(1):251-8.
1973: Varmus H E; Vogt P K; Bishop J M
Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(11):3067-71.
1973: Varmus H E; Quintrell N; Medeiros E; Bishop J M; Nowinski R C; Sarkar N H
Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains.
Journal of molecular biology 1973;79(4):663-79.
1973: Bishop J M; Jackson N; Levinson W E; Medeiros E; Quintrell N; Varmus H E
The presence and expression of RNA tumor virus genes in normal and infected cells: detection by molecular hybridization.
American journal of clinical pathology 1973;60(1):31-43.
1973: Garapin A C; Varmus H E; Faras A J; Levinson W E; Bishop J M
RNA-directed DNA synthesis by virions of Rous sarcoma virus: further characterization of the templates and the extent of their transcription.
Virology 1973;52(1):264-74.
1973: Varmus H E; Bishop J M; Vogt P K
Appearance of virus-specific DNA in mammalian cells following transformation by Rous sarcoma virus.
Journal of molecular biology 1973;74(4):613-26.
1973: Taylor J M; Faras A J; Varmus H E; Goodman H M; Levinson W E; Bishop J M
Transcription of ribonucleic acid by the ribonucleic acid directed deoxyribonucleic acid polymerase of Rous sarcoma virus and deoxyribonucleic acid polymerase I of Escherichia coli.
Biochemistry 1973;12(3):460-7.
1972: Varmus H E; Bishop J M; Nowinski R C; Sarker N H
Mammary tumour virus specific nucleotide sequences in mouse DNA.
Nature: New biology 1972;238(84):189-91.
1972: Taylor J M; Faras A J; Varmus H E; Levinson W E; Bishop J M
Ribonucleic acid directed deoxyribonucleic acid synthesis by the purified deoxyribonucleic acid polymerase of Rous sarcoma virus. Characterization of the enzymatic product.
Biochemistry 1972;11(12):2343-51.
1972: Varmus H E; Weiss R A; Friis R R; Levinson W; Bishop J M
Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells).
Proceedings of the National Academy of Sciences of the United States of America 1972;69(1):20-4.
1972: Levinson W E; Varmus H E; Garapin A C; Bishop J M
DNA of Rous sarcoma virus: its nature and significance.
Science (New York, N.Y.) 1972;175(17):76-8.
1971: Varmus H E; Levinson W E; Bishop J M
Extent of transcription by the RNA-dependent DNA polymerase of Rous sarcoma virus.
Nature: New biology 1971;233(35):19-21.
1971: Miller Z; Varmus H E; Parks J S; Perlman R L; Pastan I
Regulation of gal messenger ribonucleic acid synthesis in Escherichia coli by 3',5'-cyclic adenosine monophosphate.
The Journal of biological chemistry 1971;246(9):2898-903.
1971: Varmus H E; Perlman R L; Pastan I
Regulation of lac transcription in antibiotic-treated E. coli.
Nature: New biology 1971;230(10):41-4.
1971: De Crombrugghe B; Chen B; Gottesman M; Pastan I; Varmus H E; Emmer M; Perlman R L
Regulation of lac mRNA synthesis in a soluble cell-free system.
Nature: New biology 1971;230(10):37-40.
1971: Pastan I; Perlman R L; Emmer M; Varmus H E; DeCrombrugghe B; Chen B P; Parks J
Regulation of gene expression in Escherichia coli by cyclic AMP.
Recent progress in hormone research 1971;27():421-32.
1970: Varmus H E; Perlman R L; Pastan I
Regulation of lac transcription in Escherichia coli by cyclic adenosine 3',5'-monophosphate. Studies with deoxyribonucleic acid-ribonucleic acid hybridization and hybridization competition.
The Journal of biological chemistry 1970;245(23):6366-72.
1970: Varmus H E; Perlman R L; Pastan I
Regulation of lac messenger ribonucleic acid synthesis by cyclic adenosine 3',5'-monophosphate and glucose.
The Journal of biological chemistry 1970;245(9):2259-67.
1970: de Crombrugghe B; Varmus H E; Perlman R L; Pastan I H
Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli.
Biochemical and biophysical research communications 1970;38(5):894-901.
1969: De Crombrugghe B; Perlman R L; Varmus H E; Pastan I
Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate.
The Journal of biological chemistry 1969;244(21):5828-35.

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