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Alexander Varshavsky

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Christopher S Brower; Konstantin I Piatkov; Alexander Varshavsky
Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.
Konstantin I Piatkov; Alexander Varshavsky; Miklos Békés; Luca Colnaghi; Tony T Huang
The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.
Alexander Varshavsky
Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis.

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All Publications

2013: Christopher S Brower; Konstantin I Piatkov; Alexander Varshavsky
Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.
Molecular cell 2013;50(2):161-71.
2012: Konstantin I Piatkov; Alexander Varshavsky; Miklos Békés; Luca Colnaghi; Tony T Huang
The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.
Molecular cell 2012;48(6):926-33.
2012: Alexander Varshavsky
Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis.
Protein science : a publication of the Protein Society 2012;21(11):1634-61.
2012: Konstantin I Piatkov; Christopher S Brower; Alexander Varshavsky
The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(27):E1839-47.
2012: Alexander Varshavsky
The ubiquitin system, an immense realm.
Annual review of biochemistry 2012;81():167-76.
2012: Alexander Varshavsky
Three decades of studies to understand the functions of the ubiquitin family.
Methods in molecular biology (Clifton, N.J.) 2012;832():1-11.
2011: Boaz Kigel; Noa Rabinowicz; Alexander Varshavsky; Ofra Kessler; Gera Neufeld
Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling.
Blood 2011;118(15):4285-96.
2011: Cheol-Sang Hwang; Julia Mayerle; Hyun Kyu Song; Maja Sukalo; Alexander Varshavsky; Marie-Claude Addor; Antonio Perez Aytes; Olga Batygin; Han Brunner; Martin Zenker
Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndrome.
PloS one 2011;6(9):e24925.
2010: Cheol-Sang Hwang; Anna Shemorry; Daniel Auerbach; Alexander Varshavsky
The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.
Nature cell biology 2010;12(12):1177-85.
2010: Christopher S Brower; Lucia Veiga; Richard H Jones; Alexander Varshavsky
Mouse Dfa is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcription.
The Journal of biological chemistry 2010;285(22):17218-34.
2010: Cheol-Sang Hwang; Anna Shemorry; Alexander Varshavsky
N-terminal acetylation of cellular proteins creates specific degradation signals.
Science (New York, N.Y.) 2010;327(5968):973-7.
2009: Emmanuelle Graciet; Franziska Walter; Diarmuid O Maoiléidigh; Stephan Pollmann; Elliot M Meyerowitz; Alexander Varshavsky; Frank Wellmer
The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13618-23.
2009: Haiqing Wang; Konstantin I Piatkov; Christopher S Brower; Alexander Varshavsky
Glutamine-specific N-terminal amidase, a component of the N-end rule pathway.
Molecular cell 2009;34(6):686-95.
2009: Cheol-Sang Hwang; Anna Shemorry; Alexander Varshavsky
Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2142-7.
2009: Christopher S Brower; Alexander Varshavsky
Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.
PloS one 2009;4(11):e7757.
2008: Alexander Varshavsky
Discovery of cellular regulation by protein degradation.
The Journal of biological chemistry 2008;283(50):34469-89.
2008: Cheol-Sang Hwang; Alexander Varshavsky
Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19188-93.
2008: Alexander Varshavsky
The N-end rule at atomic resolution.
Nature structural & molecular biology 2008;15(12):1238-40.
2008: Zanxian Xia; Glenn C Turner; Cheol-Sang Hwang; Christopher Byrd; Alexander Varshavsky
Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter.
The Journal of biological chemistry 2008;283(43):28958-68.
2008: Alexander Varshavsky; Ofra Kessler; Sivan Abramovitch; Boaz Kigel; Shelly Zaffryar; Gal Akiri; Gera Neufeld
Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases.
Cancer research 2008;68(17):6922-31.
2008: Zanxian Xia; Ailsa Webster; Fangyong Du; Konstantin Piatkov; Michel Ghislain; Alexander Varshavsky
Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway.
The Journal of biological chemistry 2008;283(35):24011-28.
2008: Rebecca E Connor; Konstantin Piatkov; Alexander Varshavsky; David A Tirrell
Enzymatic N-terminal addition of noncanonical amino acids to peptides and proteins.
Chembiochem : a European journal of chemical biology 2008;9(3):366-9.
2008: Rong-Gui Hu; Haiqing Wang; Zanxian Xia; Alexander Varshavsky
The N-end rule pathway is a sensor of heme.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):76-81.
2008: Boaz Kigel; Alexander Varshavsky; Ofra Kessler; Gera Neufeld
Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells.
PloS one 2008;3(9):e3287.
2007: Pamela Schnupf; Jianmin Zhou; Alexander Varshavsky; Daniel A Portnoy
Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway.
Infection and immunity 2007;75(11):5135-47.
2007: Alexander Varshavsky
Targeting the absence: homozygous DNA deletions as immutable signposts for cancer therapy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):14935-40.
2007: Noga Guttmann-Raviv; Niva Shraga-Heled; Alexander Varshavsky; Cinthya Guimaraes-Sternberg; Ofra Kessler; Gera Neufeld
Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis.
The Journal of biological chemistry 2007;282(36):26294-305.
2007: Takafumi Tasaki; Reinhard Sohr; Zanxian Xia; Rainer Hellweg; Heide Hörtnagl; Alexander Varshavsky; Yong Tae Kwon
Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.
The Journal of biological chemistry 2007;282(25):18510-20.
2007: Gera Neufeld; Tali Lange; Alexander Varshavsky; Ofra Kessler
Semaphorin signaling in vascular and tumor biology.
Advances in experimental medicine and biology 2007;600():118-31.
2006: Alexander Varshavsky
Discovering the RNA double helix and hybridization.
Cell 2006;127(7):1295-7.
2006: Rong-Gui Hu; Christopher S Brower; Haiqing Wang; Ilia V Davydov; Jun Sheng; Jianmin Zhou; Yong Tae Kwon; Alexander Varshavsky
Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms.
The Journal of biological chemistry 2006;281(43):32559-73.
2006: Jee Young An; Jai Wha Seo; Takafumi Tasaki; Min Jae Lee; Alexander Varshavsky; Yong Tae Kwon
Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6212-7.
2006: Alexander Varshavsky
The early history of the ubiquitin field.
Protein science : a publication of the Protein Society 2006;15(3):647-54.
2006: Emmanuelle Graciet; Rong-Gui Hu; Konstantin Piatkov; Joon Haeng Rhee; Erich M Schwarz; Alexander Varshavsky
Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3078-83.
2005: Martin Zenker; Julia Mayerle; Markus M Lerch; Andreas Tagariello; Klaus Zerres; Peter Roy Durie; Matthias Beier; Georg Hülskamp; Celina Guzman; Helga Rehder; Frits A Beemer; Ben Hamel; Philippe Vanlieferinghen; Ruth Gershoni-Baruch; Marta W Vieira; Miroslav Dumic; Ron Auslender; Vera Lúcia Gil da Silva Lopes; Simone Steinlicht; Manfred Rauh; Stavit A Shalev; Christian T Thiel; Arif B Ekici; Andreas Winterpacht; Yong Tae Kwon; Alexander Varshavsky; André Reis
Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).
Nature genetics 2005;37(12):1345-50.
2005: Rong-Gui Hu; Jun Sheng; Xin Qi; Zhenming Xu; Terry T Takahashi; Alexander Varshavsky
The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators.
Nature 2005;437(7061):981-6.
2005: Takafumi Tasaki; Lubbertus C F Mulder; Akihiro Iwamatsu; Min Jae Lee; Ilia V Davydov; Alexander Varshavsky; Mark A Muesing; Yong Tae Kwon
A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.
Molecular and cellular biology 2005;25(16):7120-36.
2005: Alexander Varshavsky
Regulated protein degradation.
Trends in biochemical sciences 2005;30(6):283-6.
2005: R Jürgen Dohmen; Alexander Varshavsky
Heat-inducible degron and the making of conditional mutants.
Methods in enzymology 2005;399():799-822.
2005: Alexander Varshavsky
Ubiquitin fusion technique and related methods.
Methods in enzymology 2005;399():777-99.
2004: Jinhu Yin; Yong Tae Kwon; Alexander Varshavsky; Weidong Wang
RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.
Human molecular genetics 2004;13(20):2421-30.
2004: Alexander Varshavsky
'Spalog' and 'sequelog': neutral terms for spatial and sequence similarity.
Current biology : CB 2004;14(5):R181-3.
2004: Daniel Finley; Aaron Ciechanover; Alexander Varshavsky
Ubiquitin as a central cellular regulator.
Cell 2004;116(2 Suppl):S29-32, 2 p following S32.
2003: Yong Tae Kwon; Zanxian Xia; Jee Young An; Takafumi Tasaki; Ilia V Davydov; Jai Wha Seo; Jun Sheng; Youming Xie; Alexander Varshavsky
Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.
Molecular and cellular biology 2003;23(22):8255-71.
2003: Alexander Varshavsky
Q & A: Alexander Varshavsky.
Current biology : CB 2003;13(13):R501-2.
2003: Alexander Varshavsky
The N-end rule and regulation of apoptosis.
Nature cell biology 2003;5(5):373-6.
2002: Youming Xie; Alexander Varshavsky
UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis.
Nature cell biology 2002;4(12):1003-7.
2002: Jun Sheng; Akiko Kumagai; William G Dunphy; Alexander Varshavsky
Dissection of c-MOS degron.
The EMBO journal 2002;21(22):6061-71.
2002: Fangyong Du; Federico Navarro-Garcia; Zanxian Xia; Takafumi Tasaki; Alexander Varshavsky
Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14110-5.
2002: Yong Tae Kwon; Anna Kashina; Ilia V Davydov; Rong-Gui Hu; Jee Young An; Jai Wha Seo; Fangyong Du; Alexander Varshavsky
An essential role of N-terminal arginylation in cardiovascular development.
Science (New York, N.Y.) 2002;297(5578):96-9.
2001: Yong Tae Kwon; Zanxian Xia; Ilia V Davydov; Stewart H Lecker; Alexander Varshavsky
Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.
Molecular and cellular biology 2001;21(23):8007-21.
2001: Hai Rao; F Uhlmann; Kim Nasmyth; Alexander Varshavsky
Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability.
Nature 2001;410(6831):955-9.
2001: Youming Xie; Alexander Varshavsky
RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3056-61.
2000: Avram Hershko; Aaron Ciechanover; Alexander Varshavsky
Basic Medical Research Award. The ubiquitin system.
Nature medicine 2000;6(10):1073-81.
2000: Glenn C Turner; Alexander Varshavsky
Detecting and measuring cotranslational protein degradation in vivo.
Science (New York, N.Y.) 2000;289(5487):2117-20.
2000: Alexander Varshavsky; G Turner; F Du; Youming Xie
Felix Hoppe-Seyler Lecture 2000. The ubiquitin system and the N-end rule pathway.
Biological chemistry 2000;381(9-10):779-89.
2000: Ilia V Davydov; Alexander Varshavsky
RGS4 is arginylated and degraded by the N-end rule pathway in vitro.
The Journal of biological chemistry 2000;275(30):22931-41.
2000: Glenn C Turner; Fangyong Du; Alexander Varshavsky
Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway.
Nature 2000;405(6786):579-83.
2000: Yong Tae Kwon; Seth A Balogh; Ilia V Davydov; Anna Kashina; JK Yoon; Youming Xie; A Gaur; Lynn A Hyde; Victor H Denenberg; Alexander Varshavsky
Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.
Molecular and cellular biology 2000;20(11):4135-48.
2000: Youming Xie; Alexander Varshavsky
Physical association of ubiquitin ligases and the 26S proteasome.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2497-502.
2000: Alexander Varshavsky
Recent studies of the ubiquitin system and the N-end rule pathway.
Harvey lectures 2000;96():93-116.
2000: Alexander Varshavsky
Ubiquitin fusion technique and its descendants.
Methods in enzymology 2000;327():578-93.
1999: Youming Xie; Alexander Varshavsky
The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain.
The EMBO journal 1999;18(23):6832-44.
1999: T Suzuki; Alexander Varshavsky
Degradation signals in the lysine-asparagine sequence space.
The EMBO journal 1999;18(21):6017-26.
1999: Youming Xie; Alexander Varshavsky
The N-end rule pathway is required for import of histidine in yeast lacking the kinesin-like protein Cin8p.
Current genetics 1999;36(3):113-23.
1999: Yong Tae Kwon; F Lévy; Alexander Varshavsky
Bivalent inhibitor of the N-end rule pathway.
The Journal of biological chemistry 1999;274(25):18135-9.
1999: Martin Dünnwald; Alexander Varshavsky; Nils Johnsson
Detection of transient in vivo interactions between substrate and transporter during protein translocation into the endoplasmic reticulum.
Molecular biology of the cell 1999;10(2):329-44.
1999: F Lévy; J A Johnston; Alexander Varshavsky
Analysis of a conditional degradation signal in yeast and mammalian cells.
European journal of biochemistry / FEBS 1999;259(1-2):244-52.
1999: Yong Tae Kwon; Anna Kashina; Alexander Varshavsky
Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway.
Molecular and cellular biology 1999;19(1):182-93.
1998: Ilia V Davydov; D Patra; Alexander Varshavsky
The N-end rule pathway in Xenopus egg extracts.
Archives of biochemistry and biophysics 1998;357(2):317-25.
1998: Yong Tae Kwon; Y Reiss; VA Fried; Avram Hershko; JK Yoon; D K Gonda; P Sangan; N G Copeland; N A Jenkins; Alexander Varshavsky
The mouse and human genes encoding the recognition component of the N-end rule pathway.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):7898-903.
1998: D Finley; K Tanaka; C Mann; H Feldmann; Mark Hochstrasser; R Vierstra; S Johnston; R Hampton; J Haber; J Mccusker; P Silver; L Frontali; P Thorsness; Alexander Varshavsky; Breck E Byers; Kiran Madura; S I Reed; D Wolf; Stefan Jentsch; T Sommer; Wolfgang Baumeister; A Goldberg; VA Fried; DM Rubin; A Toh-e
Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle.
Trends in biochemical sciences 1998;23(7):244-5.
1998: Alexander Varshavsky
Codominant interference, antieffectors, and multitarget drugs.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2094-9.
1998: Paula C Ramos; J Höckendorff; Erica S Johnson; Alexander Varshavsky; R Jürgen Dohmen
Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly.
Cell 1998;92(4):489-99.
1998: C Byrd; Glenn C Turner; Alexander Varshavsky
The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor.
The EMBO journal 1998;17(1):269-77.
1997: Alexander Varshavsky
The ubiquitin system.
Trends in biochemical sciences 1997;22(10):383-7.
1997: Alexander Varshavsky
The N-end rule pathway of protein degradation.
Genes to cells : devoted to molecular & cellular mechanisms 1997;2(1):13-28.
1996: S Grigoryev; A E Stewart; Yong Tae Kwon; S M Arfin; Ralph A Bradshaw; N A Jenkins; N G Copeland; Alexander Varshavsky
A mouse amidase specific for N-terminal asparagine. The gene, the enzyme, and their function in the N-end rule pathway.
The Journal of biological chemistry 1996;271(45):28521-32.
1996: Alexander Varshavsky
The N-end rule: functions, mysteries, uses.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12142-9.
1996: M Ghislain; R J Dohmen; F Levy; Alexander Varshavsky
Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae.
The EMBO journal 1996;15(18):4884-99.
1996: F Lévy; Nils Johnsson; Till Rümenapf; Alexander Varshavsky
Using ubiquitin to follow the metabolic fate of a protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4907-12.
1995: R J Dohmen; R Stappen; J P McGrath; H Forrová; J Kolarov; A Goffeau; Alexander Varshavsky
An essential yeast gene encoding a homolog of ubiquitin-activating enzyme.
The Journal of biological chemistry 1995;270(30):18099-109.
1995: E S Johnson; P C Ma; I M Ota; Alexander Varshavsky
A proteolytic pathway that recognizes ubiquitin as a degradation signal.
The Journal of biological chemistry 1995;270(29):17442-56.
1995: R T Baker; Alexander Varshavsky
Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway.
The Journal of biological chemistry 1995;270(20):12065-74.
1995: Alexander Varshavsky
Codominance and toxins: a path to drugs of nearly unlimited selectivity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):3663-7.
1995: J A Johnston; E S Johnson; P R Waller; Alexander Varshavsky
Methotrexate inhibits proteolysis of dihydrofolate reductase by the N-end rule pathway.
The Journal of biological chemistry 1995;270(14):8172-8.
1995: Alexander Varshavsky
The N-end rule.
Cold Spring Harbor symposia on quantitative biology 1995;60():461-78.
1994: Nils Johnsson; Alexander Varshavsky
Split ubiquitin as a sensor of protein interactions in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10340-4.
1994: Kiran Madura; Alexander Varshavsky
Degradation of G alpha by the N-end rule pathway.
Science (New York, N.Y.) 1994;265(5177):1454-8.
1994: Nils Johnsson; Alexander Varshavsky
Ubiquitin-assisted dissection of protein transport across membranes.
The EMBO journal 1994;13(11):2686-98.
1994: R J Dohmen; P Wu; Alexander Varshavsky
Heat-inducible degron: a method for constructing temperature-sensitive mutants.
Science (New York, N.Y.) 1994;263(5151):1273-6.
1993: I M Ota; Alexander Varshavsky
A yeast protein similar to bacterial two-component regulators.
Science (New York, N.Y.) 1993;262(5133):566-9.
1993: T E Shrader; J W Tobias; Alexander Varshavsky
The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat.
Journal of bacteriology 1993;175(14):4364-74.
1993: Kiran Madura; R J Dohmen; Alexander Varshavsky
N-recognin/Ubc2 interactions in the N-end rule pathway.
The Journal of biological chemistry 1993;268(16):12046-54.
1992: R T Baker; J W Tobias; Alexander Varshavsky
Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family.
The Journal of biological chemistry 1992;267(32):23364-75.
1992: Alexander Varshavsky
The N-end rule.
Cell 1992;69(5):725-35.
1992: I M Ota; Alexander Varshavsky
A gene encoding a putative tyrosine phosphatase suppresses lethality of an N-end rule-dependent mutant.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2355-9.
1992: E S Johnson; B Bartel; W Seufert; Alexander Varshavsky
Ubiquitin as a degradation signal.
The EMBO journal 1992;11(2):497-505.
1991: J W Tobias; T E Shrader; G Rocap; Alexander Varshavsky
The N-end rule in bacteria.
Science (New York, N.Y.) 1991;254(5036):1374-7.
1991: R J Dohmen; Kiran Madura; B Bartel; Alexander Varshavsky
The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7351-5.
1991: J W Tobias; Alexander Varshavsky
Cloning and functional analysis of the ubiquitin-specific protease gene UBP1 of Saccharomyces cerevisiae.
The Journal of biological chemistry 1991;266(18):12021-8.
1991: Mark Hochstrasser; M J Ellison; V Chau; Alexander Varshavsky
The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4606-10.
1991: R T Baker; Alexander Varshavsky
Inhibition of the N-end rule pathway in living cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1090-4.
1991: J P McGrath; Stefan Jentsch; Alexander Varshavsky
UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme.
The EMBO journal 1991;10(1):227-36.
1990: B Bartel; I Wünning; Alexander Varshavsky
The recognition component of the N-end rule pathway.
The EMBO journal 1990;9(10):3179-89.
1990: E S Johnson; D K Gonda; Alexander Varshavsky
cis-trans recognition and subunit-specific degradation of short-lived proteins.
Nature 1990;346(6281):287-91.
1990: Mark Hochstrasser; Alexander Varshavsky
In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor.
Cell 1990;61(4):697-708.
1990: E Balzi; M Choder; W N Chen; Alexander Varshavsky; André Goffeau
Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATE1 of Saccharomyces cerevisiae.
The Journal of biological chemistry 1990;265(13):7464-71.
1989: D K Gonda; A Bachmair; I Wünning; J W Tobias; William Stratton Lane; Alexander Varshavsky
Universality and structure of the N-end rule.
The Journal of biological chemistry 1989;264(28):16700-12.
1989: J P McGrath; Alexander Varshavsky
The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein.
Nature 1989;340(6232):400-4.
1989: E Winter; Alexander Varshavsky
A DNA binding protein that recognizes oligo(dA).oligo(dT) tracts.
The EMBO journal 1989;8(6):1867-77.
1989: Daniel Finley; B Bartel; Alexander Varshavsky
The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis.
Nature 1989;338(6214):394-401.
1989: V Chau; J W Tobias; A Bachmair; D Marriott; D J Ecker; D K Gonda; Alexander Varshavsky
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein.
Science (New York, N.Y.) 1989;243(4898):1576-83.
1989: A Bachmair; Alexander Varshavsky
The degradation signal in a short-lived protein.
Cell 1989;56(6):1019-32.
1989: Alexander Varshavsky; A Bachmair; D Finley; D K Gonda; I Wünning
Targeting of proteins for degradation.
Biotechnology (Reading, Mass.) 1989;13():109-43.
1988: M G Goebl; J Yochem; Stefan Jentsch; J P McGrath; Alexander Varshavsky; Breck E Byers
The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme.
Science (New York, N.Y.) 1988;241(4871):1331-5.
1988: M J Solomon; Pamela Larsen; Alexander Varshavsky
Mapping protein-DNA interactions in vivo with formaldehyde: evidence that histone H4 is retained on a highly transcribed gene.
Cell 1988;53(6):937-47.
1988: B Bartel; Alexander Varshavsky
Hypersensitivity to heavy water: a new conditional phenotype.
Cell 1988;52(6):935-41.
1987: Alexander Varshavsky; A Bachmair; D Finley
The N-end rule of selective protein turnover: mechanistic aspects and functional implications.
Biochemical Society transactions 1987;15(5):815-6.
1987: L J Peck; L Millstein; P Eversole-Cire; Joel M Gottesfeld; Alexander Varshavsky
Transcriptionally inactive oocyte-type 5S RNA genes of Xenopus laevis are complexed with TFIIIA in vitro.
Molecular and cellular biology 1987;7(10):3503-10.
1987: M J Solomon; Alexander Varshavsky
A nuclease-hypersensitive region forms de novo after chromosome replication.
Molecular and cellular biology 1987;7(10):3822-5.
1987: Stefan Jentsch; J P McGrath; Alexander Varshavsky
The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme.
Nature 1987;329(6135):131-4.
1987: E Ozkaynak; D Finley; M J Solomon; Alexander Varshavsky
The yeast ubiquitin genes: a family of natural gene fusions.
The EMBO journal 1987;6(5):1429-39.
1987: D Finley; E Ozkaynak; Alexander Varshavsky
The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses.
Cell 1987;48(6):1035-46.
1986: A Bachmair; D Finley; Alexander Varshavsky
In vivo half-life of a protein is a function of its amino-terminal residue.
Science (New York, N.Y.) 1986;234(4773):179-86.
1986: Paul Steven Swerdlow; D Finley; Alexander Varshavsky
Enhancement of immunoblot sensitivity by heating of hydrated filters.
Analytical biochemistry 1986;156(1):147-53.
1985: J Barsoum; Alexander Varshavsky
Preferential localization of variant nucleosomes near the 5'-end of the mouse dihydrofolate reductase gene.
The Journal of biological chemistry 1985;260(12):7688-97.
1985: Aaron Ciechanover; D Finley; Alexander Varshavsky
Mammalian cell cycle mutant defective in intracellular protein degradation and ubiquitin-protein conjugation.
Progress in clinical and biological research 1985;180():17-31.
1984: E Ozkaynak; D Finley; Alexander Varshavsky
The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein.
Nature 1984;312(5995):663-6.
1984: Aaron Ciechanover; D Finley; Alexander Varshavsky
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85.
Cell 1984;37(1):57-66.
1984: D Finley; Aaron Ciechanover; Alexander Varshavsky
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85.
Cell 1984;37(1):43-55.
1984: Aaron Ciechanover; D Finley; Alexander Varshavsky
The ubiquitin-mediated proteolytic pathway and mechanisms of energy-dependent intracellular protein degradation.
Journal of cellular biochemistry 1984;24(1):27-53.
1983: Paul Steven Swerdlow; Alexander Varshavsky
Affinity of HMG17 for a mononucleosome is not influenced by the presence of ubiquitin-H2A semihistone but strongly depends on DNA fragment size.
Nucleic acids research 1983;11(2):387-401.
1982: L Levinger; Alexander Varshavsky
Selective arrangement of ubiquitinated and D1 protein-containing nucleosomes within the Drosophila genome.
Cell 1982;28(2):375-85.