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KJ Vastag

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Craig A Coburn; Diane M Rush; Peter D Williams; Carl F Homnick; Elizabeth A Lyle; S Dale Lewis; Bobby J Lucas; J M Di Muzio-Mower; M Juliano; Julie A Krueger; KJ Vastag; I-Wu Chen; Joseph P Vacca
Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.
Philip E J Sanderson; Terry A Lyle; Kellie J Cutrona; Dona L Dyer; Bruce D Dorsey; Colleen McDonough; Adel M Naylor-Olsen; I-Wu Chen; Zhongguo Chen; Jacquelynn J Cook; CM Cooper; Stephen J Gardell; TR Hare; Julie A Krueger; S Dale Lewis; Jiunn H Lin; Bobby J Lucas; Elizabeth A Lyle; Joseph J Lynch; Maria T Stranieri; KJ Vastag; Youwei Yan; Jules A Shafer; Joseph P Vacca
Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates.
M Chiba; JA Nishime; I-Wu Chen; KJ Vastag; Y S Sahly; B M Kim; Bruce D Dorsey; Joseph P Vacca; Jiunn H Lin
Metabolite-P450 complex formation by methylenedioxyphenyl HIV protease inhibitors in rat and human liver microsomes.

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All Publications

2000: Craig A Coburn; Diane M Rush; Peter D Williams; Carl F Homnick; Elizabeth A Lyle; S Dale Lewis; Bobby J Lucas; J M Di Muzio-Mower; M Juliano; Julie A Krueger; KJ Vastag; I-Wu Chen; Joseph P Vacca
Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(10):1069-72.
1998: Philip E J Sanderson; Terry A Lyle; Kellie J Cutrona; Dona L Dyer; Bruce D Dorsey; Colleen McDonough; Adel M Naylor-Olsen; I-Wu Chen; Zhongguo Chen; Jacquelynn J Cook; CM Cooper; Stephen J Gardell; TR Hare; Julie A Krueger; S Dale Lewis; Jiunn H Lin; Bobby J Lucas; Elizabeth A Lyle; Joseph J Lynch; Maria T Stranieri; KJ Vastag; Youwei Yan; Jules A Shafer; Joseph P Vacca
Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates.
Journal of medicinal chemistry 1998;41(23):4466-74.
1998: M Chiba; JA Nishime; I-Wu Chen; KJ Vastag; Y S Sahly; B M Kim; Bruce D Dorsey; Joseph P Vacca; Jiunn H Lin
Metabolite-P450 complex formation by methylenedioxyphenyl HIV protease inhibitors in rat and human liver microsomes.
Biochemical pharmacology 1998;56(2):223-30.
1998: Richard C A Isaacs; Kellie J Cutrona; Christina L Newton; Philip E J Sanderson; Mark G Solinsky; Elizabeth P Baskin; I-Wu Chen; CM Cooper; Jacquelynn J Cook; Stephen J Gardell; S Dale Lewis; R J Lucas; Elizabeth A Lyle; Joseph J Lynch; Adel M Naylor-Olsen; Maria T Stranieri; KJ Vastag; Joseph P Vacca
C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption.
Bioorganic & medicinal chemistry letters 1998;8(13):1719-24.
1998: Philip E J Sanderson; Kellie J Cutrona; Bruce D Dorsey; Dona L Dyer; Colleen McDonough; Adel M Naylor-Olsen; I-Wu Chen; Zhongguo Chen; Jacquelynn J Cook; Stephen J Gardell; Julie A Krueger; S Dale Lewis; Jiunn H Lin; Bobby J Lucas; Elizabeth A Lyle; Joseph J Lynch; Maria T Stranieri; KJ Vastag; Jules A Shafer; Joseph P Vacca
L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor.
Bioorganic & medicinal chemistry letters 1998;8(7):817-22.
1998: Stephen F Brady; Kenneth J Stauffer; William C Lumma; G M Smith; Harri G Ramjit; S Dale Lewis; Bobby J Lucas; Stephen J Gardell; Elizabeth A Lyle; SD Appleby; Jacquelynn J Cook; Marie A Holahan; Maria T Stranieri; Joseph J Lynch; Jiunn H Lin; I-Wu Chen; KJ Vastag; Adel M Naylor-Olsen; Joseph P Vacca
Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support.
Journal of medicinal chemistry 1998;41(3):401-6.
1996: Jiunn H Lin; M Chiba; I-Wu Chen; JA Nishime; KJ Vastag
Sex-dependent pharmacokinetics of indinavir: in vivo and in vitro evidence.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(12):1298-306.
1996: Jiunn H Lin; M Chiba; Suresh K Balani; I-Wu Chen; G Y Kwei; KJ Vastag; JA Nishime
Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(10):1111-20.
1995: I-Wu Chen; KJ Vastag; Jiunn H Lin
High-performance liquid chromatographic determination of a potent and selective HIV protease inhibitor (L-735,524) in rat, dog and monkey plasma.
Journal of chromatography. B, Biomedical applications 1995;672(1):111-7.
1995: Jiunn H Lin; M Chiba; I-Wu Chen; KJ Vastag; JA Nishime; Bruce D Dorsey; S R Michelson; S L McDaniel
Time- and dose-dependent pharmacokinetics of L-754,394, an HIV protease inhibitor, in rats, dogs and monkeys.
The Journal of pharmacology and experimental therapeutics 1995;274(1):264-9.
1995: Jiunn H Lin; I-Wu Chen; KJ Vastag; Drazen Ostovic
pH-dependent oral absorption of L-735,524, a potent HIV protease inhibitor, in rats and dogs.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(7):730-5.