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Richard Vaughan-Jones

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Alzbeta Hulikova; Adrian L Harris; Richard D Vaughan-Jones; Pawel Swietach
Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia.
Marie A Schroeder; Claudiu T Supuran; Mohammad A Ali; Kieran Clarke; Alzbeta Hulikova; Damian J Tyler; Richard D Vaughan-Jones; Pawel Swietach
Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics.
Alan McIntyre; Shalini Patiar; William S Sly; Cameron Snell; Pawel Swietach; Helen Turley; Richard D Vaughan-Jones; Simon Wigfield; Kevin Gatter; Ioanna Ledaki; Russell Leek; Ji-Liang Li; Adrian L Harris
Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.

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All Publications

2013: Alzbeta Hulikova; Adrian L Harris; Richard D Vaughan-Jones; Pawel Swietach
Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia.
Journal of cellular physiology 2013;228(4):743-52.
2013: Marie A Schroeder; Claudiu T Supuran; Mohammad A Ali; Kieran Clarke; Alzbeta Hulikova; Damian J Tyler; Richard D Vaughan-Jones; Pawel Swietach
Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(10):E958-67.
2012: Alan McIntyre; Shalini Patiar; William S Sly; Cameron Snell; Pawel Swietach; Helen Turley; Richard D Vaughan-Jones; Simon Wigfield; Kevin Gatter; Ioanna Ledaki; Russell Leek; Ji-Liang Li; Adrian L Harris
Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(11):3100-11.
2012: Pawel Swietach; Richard D Vaughan-Jones; Alzbeta Hulikova; Shalini Patiar; Adrian L Harris
Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin.
PloS one 2012;7(4):e35949.
2012: Alzbeta Hulikova; Adrian L Harris; Richard D Vaughan-Jones; Pawel Swietach
Acid-extrusion from tissue: the interplay between membrane transporters and pH buffers.
Current pharmaceutical design 2012;18(10):1331-7.
2011: Noriko Saegusa; Emma Moorhouse; Richard D Vaughan-Jones; Kenneth W Spitzer
Influence of pH on Ca²⁺ current and its control of electrical and Ca²⁺ signaling in ventricular myocytes.
The Journal of general physiology 2011;138(5):537-59.
2011: Alzbeta Hulikova; Richard D Vaughan-Jones; Pawel Swietach
Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths.
The Journal of biological chemistry 2011;286(16):13815-26.
2010: Pawel Swietach; Teresa Tiffert; Jakob M A Mauritz; Rachel Seear; Alessandro Esposito; Clemens F Kaminski; Virgilio L Lew; Richard D Vaughan-Jones
Hydrogen ion dynamics in human red blood cells.
The Journal of physiology 2010;588(Pt 24):4995-5014.
2010: Pawel Swietach; Patrizia Camelliti; Alzbeta Hulikova; Tahir Mansoori; Richard D Vaughan-Jones
Spatial regulation of intracellular pH in multicellular strands of neonatal rat cardiomyocytes.
Cardiovascular research 2010;85(4):729-38.
2010: Pawel Swietach; Kenneth W Spitzer; Richard D Vaughan-Jones
Modeling calcium waves in cardiac myocytes: importance of calcium diffusion.
Frontiers in bioscience : a journal and virtual library 2010;15():661-80.
2009: Pawel Swietach; Shalini Patiar; Claudiu T Supuran; Adrian L Harris; Richard D Vaughan-Jones
The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths.
The Journal of biological chemistry 2009;284(30):20299-310.
2009: Wan-Chen Huang; Pawel Swietach; Richard D Vaughan-Jones; Maike D Glitsch
Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells.
Cell calcium 2009;45(4):391-9.
2009: Andrew K Stewart; Christine E Kurschat; Richard D Vaughan-Jones; Seth L Alper
Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH.
The Journal of biological chemistry 2009;284(10):6126-39.
2009: Richard D Vaughan-Jones; Kenneth W Spitzer; Pawel Swietach
Intracellular pH regulation in heart.
Journal of molecular and cellular cardiology 2009;46(3):318-31.
2008: Richard D Vaughan-Jones; Pawel Swietach
Pushing and pulling the cardiac sodium/hydrogen exchanger.
Circulation research 2008;103(8):773-5.
2008: Pawel Swietach; Kenneth W Spitzer; Richard D Vaughan-Jones
Ca2+-mobility in the sarcoplasmic reticulum of ventricular myocytes is low.
Biophysical journal 2008;95(3):1412-27.
2008: Pawel Swietach; Simon Wigfield; Philip Cobden; Claudiu T Supuran; Adrian L Harris; Richard D Vaughan-Jones
Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.
The Journal of biological chemistry 2008;283(29):20473-83.
2008: Pawel Swietach; Simon Wigfield; Claudiu T Supuran; Adrian L Harris; Richard D Vaughan-Jones
Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2 diffusion.
BJU international 2008;101 Suppl 4():22-4.
2008: Wan-Chen Huang; Pawel Swietach; Richard D Vaughan-Jones; Olaf Ansorge; Maike D Glitsch
Extracellular acidification elicits spatially and temporally distinct Ca2+ signals.
Current biology : CB 2008;18(10):781-5.
2008: Steven A Niederer; Pawel Swietach; D A Wilson; Nicolas P Smith; Richard D Vaughan-Jones
Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte.
Biophysical journal 2008;94(6):2385-403.
2008: Frederick F-T Ch'en; F C Villafuerte; Pawel Swietach; Philip Cobden; Richard D Vaughan-Jones
S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart.
British journal of pharmacology 2008;153(5):972-82.
2007: Andrew K Stewart; Christine E Kurschat; Richard D Vaughan-Jones; Boris E Shmukler; Seth L Alper
Acute regulation of mouse AE2 anion exchanger requires isoform-specific amino acid residues from most of the transmembrane domain.
The Journal of physiology 2007;584(Pt 1):59-73.
2007: Pawel Swietach; Richard D Vaughan-Jones; Adrian L Harris
Regulation of tumor pH and the role of carbonic anhydrase 9.
Cancer metastasis reviews 2007;26(2):299-310.
2007: Pawel Swietach; alessandra rossini; Kenneth W Spitzer; Richard D Vaughan-Jones
H+ ion activation and inactivation of the ventricular gap junction: a basis for spatial regulation of intracellular pH.
Circulation research 2007;100(7):1045-54.
2007: Andrew K Stewart; Christine E Kurschat; D Burns; N Banger; Richard D Vaughan-Jones; Seth L Alper
Transmembrane domain histidines contribute to regulation of AE2-mediated anion exchange by pH.
American journal of physiology. Cell physiology 2007;292(2):C909-18.
2007: Pawel Swietach; Kenneth W Spitzer; Richard D Vaughan-Jones
pH-Dependence of extrinsic and intrinsic H(+)-ion mobility in the rat ventricular myocyte, investigated using flash photolysis of a caged-H(+) compound.
Biophysical journal 2007;92(2):641-53.
2006: Richard D Vaughan-Jones; Francisco C Villafuerte; Pawel Swietach; Taku Yamamoto; alessandra rossini; Kenneth W Spitzer
pH-Regulated Na(+) influx into the mammalian ventricular myocyte: the relative role of Na(+)-H(+) exchange and Na(+)-HCO Co-transport.
Journal of cardiovascular electrophysiology 2006;17 Suppl 1():S134-S140.
2006: Richard D Vaughan-Jones; Kenneth W Spitzer; Pawel Swietach
Spatial aspects of intracellular pH regulation in heart muscle.
Progress in biophysics and molecular biology 2006;90(1-3):207-24.
2005: Pawel Swietach; Richard D Vaughan-Jones
Relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes.
The Journal of physiology 2005;566(Pt 3):793-806.
2005: Pawel Swietach; Richard D Vaughan-Jones
Spatial regulation of intracellular pH in the ventricular myocyte.
Annals of the New York Academy of Sciences 2005;1047():271-82.
2005: Pawel Swietach; Chae Hun Leem; Kenneth W Spitzer; Richard D Vaughan-Jones
Experimental generation and computational modeling of intracellular pH gradients in cardiac myocytes.
Biophysical journal 2005;88(4):3018-37.
2005: Taku Yamamoto; Pawel Swietach; alessandra rossini; Shih-Hurng Loh; Richard D Vaughan-Jones; Kenneth W Spitzer
Functional diversity of electrogenic Na+-HCO3- cotransport in ventricular myocytes from rat, rabbit and guinea pig.
The Journal of physiology 2005;562(Pt 2):455-75.
2004: Andrew K Stewart; Nicky Kerr; Marina N Chernova; Seth L Alper; Richard D Vaughan-Jones
Acute pH-dependent regulation of AE2-mediated anion exchange involves discrete local surfaces of the NH2-terminal cytoplasmic domain.
The Journal of biological chemistry 2004;279(50):52664-76.
2004: Pawel Swietach; Richard D Vaughan-Jones
Novel method for measuring junctional proton permeation in isolated ventricular myocyte cell pairs.
American journal of physiology. Heart and circulatory physiology 2004;287(5):H2352-63.
2003: Frederick F-T Ch'en; Emma Dilworth; Pawel Swietach; Ruth S Goddard; Richard D Vaughan-Jones
Temperature dependence of Na+-H+ exchange, Na+-HCO3- co-transport, intracellular buffering and intracellular pH in guinea-pig ventricular myocytes.
The Journal of physiology 2003;552(Pt 3):715-26.
2003: Massimiliano Zaniboni; alessandra rossini; Pawel Swietach; Nurindura Banger; Kenneth W Spitzer; Richard D Vaughan-Jones
Proton permeation through the myocardial gap junction.
Circulation research 2003;93(8):726-35.
2003: Pawel Swietach; Massimiliano Zaniboni; Andrew K Stewart; alessandra rossini; Kenneth W Spitzer; Richard D Vaughan-Jones
Modelling intracellular H(+) ion diffusion.
Progress in biophysics and molecular biology 2003;83(2):69-100.
2003: Massimiliano Zaniboni; Pawel Swietach; alessandra rossini; Taku Yamamoto; Kenneth W Spitzer; Richard D Vaughan-Jones
Intracellular proton mobility and buffering power in cardiac ventricular myocytes from rat, rabbit, and guinea pig.
American journal of physiology. Heart and circulatory physiology 2003;285(3):H1236-46.
2002: Leila V Virkki; Darren A Wilson; Richard D Vaughan-Jones; Walter F Boron
Functional characterization of human NBC4 as an electrogenic Na+-HCO cotransporter (NBCe2).
American journal of physiology. Cell physiology 2002;282(6):C1278-89.
2002: Kenneth W Spitzer; RL Skolnick; B E Peercy; James P Keener; Richard D Vaughan-Jones
Facilitation of intracellular H(+) ion mobility by CO(2)/HCO(3)(-) in rabbit ventricular myocytes is regulated by carbonic anhydrase.
The Journal of physiology 2002;541(Pt 1):159-67.
2002: Richard D Vaughan-Jones; B E Peercy; James P Keener; Kenneth W Spitzer
Intrinsic H(+) ion mobility in the rabbit ventricular myocyte.
The Journal of physiology 2002;541(Pt 1):139-58.
2002: Richard D Vaughan-Jones; Kenneth W Spitzer
Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(5):579-96.
2001: Shih-Hurng Loh; Chien-Sung Tsai; Cheng-I Lin; Jong-Shiaw Jin; Richard D Vaughan-Jones
Effect of S20787, a novel Cl--HCO3- exchange inhibitor, on intracellular pH regulation in guinea pig ventricular myocytes.
Journal of biomedical science 2001;8(5):395-405.
2000: C D Balnave; Richard D Vaughan-Jones
Effect of intracellular pH on spontaneous Ca2+ sparks in rat ventricular myocytes.
The Journal of physiology 2000;528 Pt 1():25-37.
2000: leonardo dasso; Keith J Buckler; Richard D Vaughan-Jones
Interactions between hypoxia and hypercapnic acidosis on calcium signaling in carotid body type I cells.
American journal of physiology. Lung cellular and molecular physiology 2000;279(1):L36-42.
2000: Kenneth W Spitzer; Philip R Ershler; RL Skolnick; Richard D Vaughan-Jones
Generation of intracellular pH gradients in single cardiac myocytes with a microperfusion system.
American journal of physiology. Heart and circulatory physiology 2000;278(4):H1371-82.
2000: K L Tsai; Richard D Vaughan-Jones; Keith J Buckler
A dual acid-influx transport system in the carotid body type I cell. Acid influx in carotid body type I cells.
Advances in experimental medicine and biology 2000;475():723-32.
1999: Chae Hun Leem; D Lagadic-Gossmann; Richard D Vaughan-Jones
Characterization of intracellular pH regulation in the guinea-pig ventricular myocyte.
The Journal of physiology 1999;517 ( Pt 1)():159-80.
1999: A K Stewart; C A R Boyd; Richard D Vaughan-Jones
A novel role for carbonic anhydrase: cytoplasmic pH gradient dissipation in mouse small intestinal enterocytes.
The Journal of physiology 1999;516 ( Pt 1)():209-17.
1998: Keith J Buckler; Richard D Vaughan-Jones
Effects of mitochondrial uncouplers on intracellular calcium, pH and membrane potential in rat carotid body type I cells.
The Journal of physiology 1998;513 ( Pt 3)():819-33.
1998: Chae Hun Leem; Richard D Vaughan-Jones
Sarcolemmal mechanisms for pHi recovery from alkalosis in the guinea-pig ventricular myocyte.
The Journal of physiology 1998;509 ( Pt 2)():487-96.
1998: Chae Hun Leem; Richard D Vaughan-Jones
Out-of-equilibrium pH transients in the guinea-pig ventricular myocyte.
The Journal of physiology 1998;509 ( Pt 2)():471-85.
1998: CS Temple; Andrew K Stewart; David Meredith; Norma Lister; Keith M Morgan; Ian D Collier; Richard D Vaughan-Jones; C A R Boyd; Patrick D Bailey; JR Bronk
Peptide mimics as substrates for the intestinal peptide transporter.
The Journal of biological chemistry 1998;273(1):20-2.
1998: Frederick F-T Ch'en; Richard D Vaughan-Jones; Kieran Clarke; Denis Noble
Modelling myocardial ischaemia and reperfusion.
Progress in biophysics and molecular biology 1998;69(2-3):515-38.
1997: C Hun Leem; Richard D Vaughan-Jones
Chloride-hydroxyl exchange in the guinea-pig ventricular myocyte: no role for bicarbonate.
Journal of molecular and cellular cardiology 1997;29(9):2483-9.
1997: P H Richmond; Richard D Vaughan-Jones
Assessment of evidence for K+-H+ exchange in isolated type-1 cells of neonatal rat carotid body.
Pflügers Archiv : European journal of physiology 1997;434(4):429-37.
1997: leonardo dasso; Keith J Buckler; Richard D Vaughan-Jones
Muscarinic and nicotinic receptors raise intracellular Ca2+ levels in rat carotid body type I cells.
The Journal of physiology 1997;498 ( Pt 2)():327-38.
1997: Frederick F-T Ch'en; Kieran Clarke; Richard D Vaughan-Jones; Denis Noble
Modeling of internal pH, ion concentration, and bioenergetic changes during myocardial ischemia.
Advances in experimental medicine and biology 1997;430():281-90.
1996: B Sun; Chae Hun Leem; Richard D Vaughan-Jones
Novel chloride-dependent acid loader in the guinea-pig ventricular myocyte: part of a dual acid-loading mechanism.
The Journal of physiology 1996;495 ( Pt 1)():65-82.
1996: S H Loh; B Sun; Richard D Vaughan-Jones
Effect of Hoe 694, a novel Na(+)-H+ exchange inhibitor, on intracellular pH regulation in the guinea-pig ventricular myocyte.
British journal of pharmacology 1996;118(8):1905-12.
1996: leonardo dasso; Keith J Buckler; Richard D Vaughan-Jones
Acetylcholine elevates intracellular Ca2+ via muscarinic and nicotinic receptors in rat carotid body type I cells.
Advances in experimental medicine and biology 1996;410():239-44.
1994: M L Wu; Richard D Vaughan-Jones
Effect of metabolic inhibitors and second messengers upon Na(+)-H+ exchange in the sheep cardiac Purkinje fibre.
The Journal of physiology 1994;478 ( Pt 2)():301-13.
1994: Keith J Buckler; Richard D Vaughan-Jones
Effects of hypercapnia on membrane potential and intracellular calcium in rat carotid body type I cells.
The Journal of physiology 1994;478 ( Pt 1)():157-71.
1994: Keith J Buckler; Richard D Vaughan-Jones
Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells.
The Journal of physiology 1994;476(3):423-8.
1994: Keith J Buckler; Richard D Vaughan-Jones
Role of intracellular pH and [Ca2+]i in acid chemoreception in type-I cells of the carotid body.
Advances in experimental medicine and biology 1994;360():41-55.
1993: Keith J Buckler; Richard D Vaughan-Jones
Effects of acidic stimuli on intracellular calcium in isolated type I cells of the neonatal rat carotid body.
Pflügers Archiv : European journal of physiology 1993;425(1-2):22-7.
1993: D Lagadic-Gossmann; Richard D Vaughan-Jones
Coupling of dual acid extrusion in the guinea-pig isolated ventricular myocyte to alpha 1- and beta-adrenoceptors.
The Journal of physiology 1993;464():49-73.
1993: Richard D Vaughan-Jones; Keith J Buckler; Chris Peers; P C Nye
Regulation of intracellular pH in type I cells of the neonatal rat carotid body.
Advances in experimental medicine and biology 1993;337():251-6.
1993: Keith J Buckler; Richard D Vaughan-Jones; Chris Peers; D Lagadic-Gossmann; P C Nye
The modulation of intracellular pH in carotid body glomus cells by extracellular pH and pCO2.
Advances in experimental medicine and biology 1993;337():103-9.
1992: D Lagadic-Gossmann; Richard D Vaughan-Jones; Keith J Buckler
Adrenaline and extracellular ATP switch between two modes of acid extrusion in the guinea-pig ventricular myocyte.
The Journal of physiology 1992;458():385-407.
1992: D Lagadic-Gossmann; Keith J Buckler; Richard D Vaughan-Jones
Role of bicarbonate in pH recovery from intracellular acidosis in the guinea-pig ventricular myocyte.
The Journal of physiology 1992;458():361-84.
1992: C Dart; Richard D Vaughan-Jones
Na(+)-HCO3- symport in the sheep cardiac Purkinje fibre.
The Journal of physiology 1992;451():365-85.
1991: Keith J Buckler; Richard D Vaughan-Jones; Chris Peers; D Lagadic-Gossmann; P C Nye
Effects of extracellular pH, PCO2 and HCO3- on intracellular pH in isolated type-I cells of the neonatal rat carotid body.
The Journal of physiology 1991;444():703-21.
1991: Keith J Buckler; Richard D Vaughan-Jones; Chris Peers; P C Nye
Intracellular pH and its regulation in isolated type I carotid body cells of the neonatal rat.
The Journal of physiology 1991;436():107-29.
1990: R N Gasser; Richard D Vaughan-Jones
Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle.
The Journal of physiology 1990;431():713-41.
1990: Keith J Buckler; Richard D Vaughan-Jones
Application of a new pH-sensitive fluoroprobe (carboxy-SNARF-1) for intracellular pH measurement in small, isolated cells.
Pflügers Archiv : European journal of physiology 1990;417(2):234-9.
1990: Richard D Vaughan-Jones; M L Wu
Extracellular H+ inactivation of Na(+)-H+ exchange in the sheep cardiac Purkinje fibre.
The Journal of physiology 1990;428():441-66.
1990: Richard D Vaughan-Jones; M L Wu
pH dependence of intrinsic H+ buffering power in the sheep cardiac Purkinje fibre.
The Journal of physiology 1990;425():429-48.
1990: C Bountra; T Powell; Richard D Vaughan-Jones
Comparison of intracellular pH transients in single ventricular myocytes and isolated ventricular muscle of guinea-pig.
The Journal of physiology 1990;424():343-65.
1989: C Bountra; Richard D Vaughan-Jones
Effect of intracellular and extracellular pH on contraction in isolated, mammalian cardiac muscle.
The Journal of physiology 1989;418():163-87.
1989: Richard D Vaughan-Jones; M L Wu; C Bountra
Sodium-hydrogen exchange and its role in controlling contractility during acidosis in cardiac muscle.
Molecular and cellular biochemistry 1989;89(2):157-62.
1988: C Bountra; Kai Kaila; Richard D Vaughan-Jones
Mechanism of rate-dependent pH changes in the sheep cardiac Purkinje fibre.
The Journal of physiology 1988;406():483-501.
1988: C Bountra; Kai Kaila; Richard D Vaughan-Jones
Effect of repetitive activity upon intracellular pH, sodium and contraction in sheep cardiac Purkinje fibres.
The Journal of physiology 1988;398():341-60.
1988: Richard D Vaughan-Jones
Regulation of intracellular pH in cardiac muscle.
Ciba Foundation symposium 1988;139():23-46.
1987: Kai Kaila; Richard D Vaughan-Jones
Influence of sodium-hydrogen exchange on intracellular pH, sodium and tension in sheep cardiac Purkinje fibres.
The Journal of physiology 1987;390():93-118.
1987: Kai Kaila; Richard D Vaughan-Jones; C Bountra
Regulation of intracellular pH in sheep cardiac Purkinje fibre: interactions among Na+, H+, and Ca2+1.
Canadian journal of physiology and pharmacology 1987;65(5):963-9.