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Timothy Bowen

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Chemicals & Drugs

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Timothy Bowen; Robert H Jenkins; Donald J Fraser
MicroRNAs, transforming growth factor beta-1, and tissue fibrosis.
Robert H Jenkins; John Martin; Aled O Phillips; Timothy Bowen; Donald J Fraser
Pleiotropy of microRNA-192 in the kidney.
Robert H Jenkins; John Martin; Aled O Phillips; Timothy Bowen; Donald J Fraser
Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding.

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All Publications

2013: Timothy Bowen; Robert H Jenkins; Donald J Fraser
MicroRNAs, transforming growth factor beta-1, and tissue fibrosis.
The Journal of pathology 2013;229(2):274-85.
2012: Robert H Jenkins; John Martin; Aled O Phillips; Timothy Bowen; Donald J Fraser
Pleiotropy of microRNA-192 in the kidney.
Biochemical Society transactions 2012;40(4):762-7.
2012: Robert H Jenkins; John Martin; Aled O Phillips; Timothy Bowen; Donald J Fraser
Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding.
The Biochemical journal 2012;443(2):407-16.
2011: John Martin; Aled O Phillips; Rasha Bennagi; Timothy Bowen; Robert H Jenkins; Aleksandra Krupa; Donald J Fraser
Post-transcriptional regulation of Transforming Growth Factor Beta-1 by microRNA-744.
PloS one 2011;6(10):e25044.
2011: Hassan Khammas; Timothy Bowen; John David Williams; Aled O Phillips; Robert Steadman; John Martin
Characterisation of the human ADAM15 promoter.
Nephron. Experimental nephrology 2011;118(2):e27-38.
2009: Russell M L Simpson; Soma Meran; David Thomas; Philip Stephens; Timothy Bowen; Robert Steadman; Aled Phillips
Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation.
The American journal of pathology 2009;175(5):1915-28.
2009: Lei Zhang; Timothy Bowen; Fiona Grennan-Jones; Carol Paddon; Peter Giles; Jason Webber; Robert Steadman; Marian Ludgate
Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: contributory role in hyaluronan accumulation in thyroid dysfunction.
The Journal of biological chemistry 2009;284(39):26447-55.
2007: Soma Meran; David Thomas; Philip Stephens; John Martin; Timothy Bowen; Aled Phillips; Robert Steadman
Involvement of hyaluronan in regulation of fibroblast phenotype.
The Journal of biological chemistry 2007;282(35):25687-97.
2006: John Martin; Timothy Bowen; Robert Steadman
The pluripotent cytokine pleiotrophin is induced by wounding in human mesangial cells.
Kidney international 2006;70(9):1616-22.
2006: Wisam Selbi; Carol de la Motte; Vincent C Hascall; Anthony J Day; Timothy Bowen; Aled O Phillips
Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells.
Kidney international 2006;70(7):1287-95.
2006: Jamie Monslow; John D Williams; Donald J Fraser; Daryn R Michael; Pelagia Foka; Ann P Kift-Morgan; Dong Dong Luo; Ceri Fielding; Kathrine J Craig; Nicholas Topley; Simon A Jones; Dipak P Ramji; Timothy Bowen
Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene.
The Journal of biological chemistry 2006;281(26):18043-50.
2006: Wisam Selbi; Anthony J Day; Marilyn S Rugg; Csaba Fülöp; Carol de la Motte; Timothy Bowen; Vincent C Hascall; Aled O Phillips
Overexpression of hyaluronan synthase 2 alters hyaluronan distribution and function in proximal tubular epithelial cells.
Journal of the American Society of Nephrology : JASN 2006;17(6):1553-67.
2005: Nicholas Topley; Daryn Michael; Timothy Bowen
CA125: holy grail or a poisoned chalice.
Nephron. Clinical practice 2005;100(2):c52-4.
2004: Jamie Monslow; John D Williams; Carol A Guy; Iain K Price; Kathrine J Craig; Hywel J Williams; Nigel M Williams; John Martin; Sharon L Coleman; Nicholas Topley; Andrew P Spicer; Paul R Buckland; Malcolm Davies; Timothy Bowen
Identification and analysis of the promoter region of the human hyaluronan synthase 2 gene.
The Journal of biological chemistry 2004;279(20):20576-81.
2003: Bastiaan Hoogendoorn; Sharon L Coleman; Carol A Guy; Kaye Smith; Timothy Bowen; Paul R Buckland; Michael C O'Donovan
Functional analysis of human promoter polymorphisms.
Human molecular genetics 2003;12(18):2249-54.
2003: Jamie Monslow; John D Williams; Nadine Norton; Carol A Guy; Iain K Price; Sharon L Coleman; Nigel M Williams; Paul R Buckland; Andrew P Spicer; Nicholas Topley; Malcolm Davies; Timothy Bowen
The human hyaluronan synthase genes: genomic structures, proximal promoters and polymorphic microsatellite markers.
The international journal of biochemistry & cell biology 2003;35(8):1272-83.
2002: Nigel M Williams; Timothy Bowen; Gillian Spurlock; Nadine Norton; Hywel J Williams; Bastiaan Hoogendoorn; Michael J Owen; Michael C O'Donovan
Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.
Molecular psychiatry 2002;7(5):508-14.
2001: Timothy Bowen; N Williams; Nadine Norton; Gillian Spurlock; Oliver H Wittekindt; Deborah J Morris-Rosendahl; Hywel Williams; L Brzustowicz; Bastiaan Hoogendoorn; Stanley Zammit; G Jones; Robert D Sanders; Lisa Anne Jones; G McCarthy; S Jones; A Bassett; Alastair G Cardno; Michael J Owen; Michael C O'Donovan
Mutation screening of the KCNN3 gene reveals a rare frameshift mutation.
Molecular psychiatry 2001;6(3):259-60.
2000: John B Vincent; Qiu-Ping Yuan; Martin Schalling; Rolf Adolfsson; Maria H Azevedo; antonio macedo; A Bauer; C DallaTorre; Helena Medeiros; Michele T Pato; Carlos N Pato; Timothy Bowen; Carol A Guy; Michael J Owen; Michael C O'Donovan; Andrew D Paterson; Arturas Petronis; James L Kennedy
Long repeat tracts at SCA8 in major psychosis.
American journal of medical genetics 2000;96(6):873-6.
2000: Timothy Bowen; L Ashworth; George Kirov; Carol A Guy; Ian Richard Jones; Fiona McCandless; Nick Craddock; Michael C O'Donovan; Michael J Owen
No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder.
Bipolar disorders 2000;2(4):328-31.
2000: Nicholas J Bray; Nigel M Williams; Timothy Bowen; Alastair G Cardno; Marion Gray; Lisa Anne Jones; Kieran C Murphy; Robert D Sanders; Gillian Spurlock; M C Odonovan; Michael J Owen
No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia.
Psychiatric genetics 2000;10(2):83-6.
2000: Timothy Bowen; Carol A Guy; Alastair G Cardno; John B Vincent; James L Kennedy; Lisa Anne Jones; Marion Gray; Robert D Sanders; G McCarthy; Kieran C Murphy; Michael J Owen; Michael C O'Donovan
Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia.
Psychiatric genetics 2000;10(1):33-7.
2000: J Austin; Bastiaan Hoogendoorn; Paul R Buckland; G Speight; Alastair G Cardno; Timothy Bowen; Nigel Williams; Gillian Spurlock; R Sanders; Lesley Jones; K Murphy; G McCarthy; Peter McGuffin; Michael J Owen; Michael C O'Donovan
Comparative sequencing of the proneurotensin gene and association studies in schizophrenia.
Molecular psychiatry 2000;5(2):208-12.
1999: Timothy Bowen; George Kirov; Michael Gill; Gillian Spurlock; Homero Vallada; R M Murray; Peter McGuffin; DA Collier; Michael J Owen; Nick Craddock
Linkage studies of bipolar disorder with chromosome 18 markers.
American journal of medical genetics 1999;88(5):503-9.
1999: Carol A Guy; Timothy Bowen; Ian Jones; Fiona McCandless; Michael J Owen; Nick Craddock; Michael C O'Donovan
CTG18.1 and ERDA-1 CAG/CTG repeat size in bipolar disorder.
Neurobiology of disease 1999;6(4):302-7.
1999: Alastair G Cardno; Timothy Bowen; Carol A Guy; Lisa Anne Jones; G McCarthy; Nigel M Williams; Kieran C Murphy; Gillian Spurlock; Marion Gray; Robert D Sanders; Nick Craddock; Peter McGuffin; Michael J Owen; Michael C O'Donovan
CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia.
Biological psychiatry 1999;45(12):1592-6.
1999: EK Franks; Carol Guy; N Jacobsen; Timothy Bowen; Michael J Owen; Michael C O'Donovan; Nick Craddock
Eleven trinucleotide repeat loci that map to chromosome 12 excluded from involvement in the pathogenesis of bipolar disorder.
American journal of medical genetics 1999;88(1):67-70.
1999: Carol A Guy; Timothy Bowen; Nigel Williams; Ian Richard Jones; Fiona McCandless; Peter McGuffin; Michael J Owen; Nick Craddock; Michael C O'Donovan
No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder.
American journal of medical genetics 1999;88(1):57-60.
1998: Timothy Bowen; Carol A Guy; Nick Craddock; Alastair G Cardno; Nigel M Williams; Gillian Spurlock; Kieran C Murphy; Lisa Anne Jones; Marion Gray; Robert D Sanders; G McCarthy; K George Chandy; Emmanuelle Fantino; Katalin Kalman; George A Gutman; J Jay Gargus; Julie Williams; Peter McGuffin; Michael J Owen; Michael C O'Donovan
Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia.
Molecular psychiatry 1998;3(3):266-9.
1998: Alastair G Cardno; Fiona McCandless; Timothy Bowen; Carol A Guy; Lisa Anne Jones; Kieran C Murphy; Peter McGuffin; Michael J Owen; Nick Craddock; Michael C O'Donovan
Association between functional psychosis and expanded CAG/CTG repeats is not explained by health stratification.
Psychiatric genetics 1998;8(1):29-32.
1998: Timothy Bowen; Nadine Norton; NJ Jacobsen; Carol Guy; johanna k macpherson; Robert D Sanders; Alastair G Cardno; Lisa Anne Jones; Kieran C Murphy; Peter McGuffin; Nick Craddock; Michael C O'Donovan; Michael J Owen
Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder.
Molecular psychiatry 1998;3(1):67-71.
1997: Carol Guy; Timothy Bowen; johanna k macpherson; G Speight; Patrick McKeon; Lesley Mynett-Johnson; E Claffey; Peter McGuffin; Michael J Owen; Nick Craddock; Michael C O'Donovan
Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder.
The American journal of psychiatry 1997;154(8):1146-7.
1997: G Speight; Carol Guy; Timothy Bowen; Philip Asherson; Peter McGuffin; Nick Craddock; Michael J Owen; Michael C O'Donovan
Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia.
American journal of medical genetics 1997;74(2):204-6.
1996: Michael C O'Donovan; Carol Guy; Nick Craddock; Timothy Bowen; Patrick McKeon; antonio macedo; W Maier; D Wildenauer; Harald N Aschauer; Sandro Sorbi; E Feldman; Lesley Mynett-Johnson; E Claffey; Benedetta Nacmias; José Valente; Ana Dourado; E Grassi; Elisabeth Lenzinger; Angela Heiden; S Moorhead; D Harrison; Julie Williams; Peter McGuffin; Michael J Owen
Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder.
Psychological medicine 1996;26(6):1145-53.
1996: Timothy Bowen; Carol Guy; G Speight; L Jones; Alastair G Cardno; K Murphy; Peter McGuffin; Michael J Owen; Michael C O'Donovan
Expansion of 50 CAG/CTG repeats excluded in schizophrenia by application of a highly efficient approach using repeat expansion detection and a PCR screening set.
American journal of human genetics 1996;59(4):912-7.