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Victor Velculescu

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.8 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
He Yiping; Wu Jian; Dressman Devin C; Iacobuzio-Donahue Christine; Markowitz Sanford D; Velculescu Victor E; Diaz Luis A; Kinzler Kenneth W; Vogelstein Bert; Papadopoulos Nickolas
Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.
Leary Rebecca J; Kinde Isaac; Diehl Frank; Schmidt Kerstin; Clouser Chris; Duncan Cisilya; Antipova Alena; Lee Clarence; McKernan Kevin; De La Vega Francisco M; Kinzler Kenneth W; Vogelstein Bert; Diaz Luis A; Velculescu Victor E
Development of personalized tumor biomarkers using massively parallel sequencing.
Ericson Kajsa; Gan Christine; Cheong Ian; Rago Carlo; Samuels Yardena; Velculescu Victor E; Kinzler Kenneth W; Huso David L; Vogelstein Bert; Papadopoulos Nickolas
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.

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All Publications

2010: He Yiping; Wu Jian; Dressman Devin C; Iacobuzio-Donahue Christine; Markowitz Sanford D; Velculescu Victor E; Diaz Luis A; Kinzler Kenneth W; Vogelstein Bert; Papadopoulos Nickolas
Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.
Nature 2010;464(7288):610-4.
2010: Leary Rebecca J; Kinde Isaac; Diehl Frank; Schmidt Kerstin; Clouser Chris; Duncan Cisilya; Antipova Alena; Lee Clarence; McKernan Kevin; De La Vega Francisco M; Kinzler Kenneth W; Vogelstein Bert; Diaz Luis A; Velculescu Victor E
Development of personalized tumor biomarkers using massively parallel sequencing.
Science translational medicine 2010;2(20):20ra14.
2010: Ericson Kajsa; Gan Christine; Cheong Ian; Rago Carlo; Samuels Yardena; Velculescu Victor E; Kinzler Kenneth W; Huso David L; Vogelstein Bert; Papadopoulos Nickolas
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2598-603.
2009: Yan Hai; Bigner Darell D; Velculescu Victor; Parsons D Williams
Mutant metabolic enzymes are at the origin of gliomas.
Cancer research 2009;69(24):9157-9.
2009: Yun Jihye; Rago Carlo; Cheong Ian; Pagliarini Ray; Angenendt Philipp; Rajagopalan Harith; Schmidt Kerstin; Willson James K V; Markowitz Sandy; Zhou Shibin; Diaz Luis A; Velculescu Victor E; Lengauer Christoph; Kinzler Kenneth W; Vogelstein Bert; Papadopoulos Nickolas
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.
Science (New York, N.Y.) 2009;325(5947):1555-9.
2009: Li Meng; Chen Wei-Dong; Papadopoulos Nickolas; Goodman Steven N; Bjerregaard Niels Christian; Laurberg Søren; Levin Bernard; Juhl Hartmut; Arber Nadir; Moinova Helen; Durkee Kris; Schmidt Kerstin; He Yiping; Diehl Frank; Velculescu Victor E; Zhou Shibin; Diaz Luis A; Kinzler Kenneth W; Markowitz Sanford D; Vogelstein Bert
Sensitive digital quantification of DNA methylation in clinical samples.
Nature biotechnology 2009;27(9):858-63.
2009: Carter Hannah; Chen Sining; Isik Leyla; Tyekucheva Svitlana; Velculescu Victor E; Kinzler Kenneth W; Vogelstein Bert; Karchin Rachel
Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations.
Cancer research 2009;69(16):6660-7.
2009: Guda Kishore; Moinova Helen; He Jian; Jamison Oliver; Ravi Lakshmeswari; Natale Leanna; Lutterbaugh James; Lawrence Earl; Lewis Susan; Willson James K V; Lowe John B; Wiesner Georgia L; Parmigiani Giovanni; Barnholtz-Sloan Jill; Dawson Dawn W; Velculescu Victor E; Kinzler Kenneth W; Papadopoulos Nikolas; Vogelstein Bert; Willis Joseph; Gerken Thomas A; Markowitz Sanford D
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12921-5.
2009: Blackford Amanda; Serrano Oscar K; Wolfgang Christopher L; Parmigiani Giovanni; Jones Siân; Zhang Xiaosong; Parsons D Williams; Lin Jimmy Cheng-Ho; Leary Rebecca J; Eshleman James R; Goggins Michael; Jaffee Elizabeth M; Iacobuzio-Donahue Christine A; Maitra Anirban; Cameron John L; Olino Kelly; Schulick Richard; Winter Jordan; Herman Joseph M; Laheru Daniel; Klein Alison P; Vogelstein Bert; Kinzler Kenneth W; Velculescu Victor E; Hruban Ralph H
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(14):4674-9.
2009: Kuo Kuan-Ting; Mao Tsui-Lien; Jones Siân; Veras Emanuela; Ayhan Ayse; Wang Tian-Li; Glas Ruth; Slamon Dennis; Velculescu Victor E; Kuman Robert J; Shih Ie-Ming
Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma.
The American journal of pathology 2009;174(5):1597-601.
2009: Blackford Amanda; Parmigiani Giovanni; Kensler Thomas W; Wolfgang Christopher; Jones Siân; Zhang Xiaosong; Parsons D Willams; Lin Jimmy Cheng-Ho; Leary Rebecca J; Eshleman James R; Goggins Michael; Jaffee Elizabeth M; Iacobuzio-Donahue Christine A; Maitra Anirban; Klein Alison; Cameron John L; Olino Kelly; Schulick Richard; Winter Jordan; Vogelstein Bert; Velculescu Victor E; Kinzler Kenneth W; Hruban Ralph H
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Cancer research 2009;69(8):3681-8.
2009: Jones Siân; Hruban Ralph H; Kamiyama Mihoko; Borges Michael; Zhang Xiaosong; Parsons D Williams; Lin Jimmy Cheng-Ho; Palmisano Emily; Brune Kieran; Jaffee Elizabeth M; Iacobuzio-Donahue Christine A; Maitra Anirban; Parmigiani Giovanni; Kern Scott E; Velculescu Victor E; Kinzler Kenneth W; Vogelstein Bert; Eshleman James R; Goggins Michael; Klein Alison P
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.
Science (New York, N.Y.) 2009;324(5924):217.
2009: Yan Hai; Parsons D Williams; Jin Genglin; McLendon Roger; Rasheed B Ahmed; Yuan Weishi; Kos Ivan; Batinic-Haberle Ines; Jones Siân; Riggins Gregory J; Friedman Henry; Friedman Allan; Reardon David; Herndon James; Kinzler Kenneth W; Velculescu Victor E; Vogelstein Bert; Bigner Darell D
IDH1 and IDH2 mutations in gliomas.
The New England journal of medicine 2009;360(8):765-73.
2009: Parmigiani Giovanni; Boca Simina; Lin Jimmy; Kinzler Kenneth W; Velculescu Victor; Vogelstein Bert
Design and analysis issues in genome-wide somatic mutation studies of cancer.
Genomics 2009;93(1):17-21.
2009: Duncan Christopher G; Leary Rebecca J; Lin Jimmy Cheng-Ho; Cummins Jordan; Di Chunhui; Schaefer Carl F; Wang Tian-Li; Riggins Gregory J; Edwards Jennifer; Bigner Darell; Kopelovich Levy; Vogelstein Bert; Kinzler Kenneth W; Velculescu Victor E; Yan Hai
Identification of microbial DNA in human cancer.
BMC medical genomics 2009;2():22.
2008: He Yiping; Vogelstein Bert; Velculescu Victor E; Papadopoulos Nickolas; Kinzler Kenneth W
The antisense transcriptomes of human cells.
Science (New York, N.Y.) 2008;322(5909):1855-7.
2008: Leary Rebecca J; Lin Jimmy C; Cummins Jordan; Boca Simina; Wood Laura D; Parsons D Williams; Jones Siân; Sjöblom Tobias; Park Ben-Ho; Parsons Ramon; Willis Joseph; Dawson Dawn; Willson James K V; Nikolskaya Tatiana; Nikolsky Yuri; Kopelovich Levy; Papadopoulos Nick; Pennacchio Len A; Wang Tian-Li; Markowitz Sanford D; Parmigiani Giovanni; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16224-9.
2008: Jones Siân; Zhang Xiaosong; Parsons D Williams; Lin Jimmy Cheng-Ho; Leary Rebecca J; Angenendt Philipp; Mankoo Parminder; Carter Hannah; Kamiyama Hirohiko; Jimeno Antonio; Hong Seung-Mo; Fu Baojin; Lin Ming-Tseh; Calhoun Eric S; Kamiyama Mihoko; Walter Kimberly; Nikolskaya Tatiana; Nikolsky Yuri; Hartigan James; Smith Douglas R; Hidalgo Manuel; Leach Steven D; Klein Alison P; Jaffee Elizabeth M; Goggins Michael; Maitra Anirban; Iacobuzio-Donahue Christine; Eshleman James R; Kern Scott E; Hruban Ralph H; Karchin Rachel; Papadopoulos Nickolas; Parmigiani Giovanni; Vogelstein Bert; Velculescu Victor E; Kinzler Kenneth W
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
Science (New York, N.Y.) 2008;321(5897):1801-6.
2008: Parsons D Williams; Jones Siân; Zhang Xiaosong; Lin Jimmy Cheng-Ho; Leary Rebecca J; Angenendt Philipp; Mankoo Parminder; Carter Hannah; Siu I-Mei; Gallia Gary L; Olivi Alessandro; McLendon Roger; Rasheed B Ahmed; Keir Stephen; Nikolskaya Tatiana; Nikolsky Yuri; Busam Dana A; Tekleab Hanna; Diaz Luis A; Hartigan James; Smith Doug R; Strausberg Robert L; Marie Suely Kazue Nagahashi; Shinjo Sueli Mieko Oba; Yan Hai; Riggins Gregory J; Bigner Darell D; Karchin Rachel; Papadopoulos Nick; Parmigiani Giovanni; Vogelstein Bert; Velculescu Victor E; Kinzler Kenneth W
An integrated genomic analysis of human glioblastoma multiforme.
Science (New York, N.Y.) 2008;321(5897):1807-12.
2008: Velculescu Victor E
Defining the blueprint of the cancer genome.
Carcinogenesis 2008;29(6):1087-91.
2008: Chan Timothy A; Glockner Sabine; Yi Joo Mi; Chen Wei; Van Neste Leander; Cope Leslie; Herman James G; Velculescu Victor; Schuebel Kornel E; Ahuja Nita; Baylin Stephen B
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.
PLoS medicine 2008;5(5):e114.
2008: Jones Siân; Chen Wei-Dong; Parmigiani Giovanni; Diehl Frank; Beerenwinkel Niko; Antal Tibor; Traulsen Arne; Nowak Martin A; Siegel Christopher; Velculescu Victor E; Kinzler Kenneth W; Vogelstein Bert; Willis Joseph; Markowitz Sanford D
Comparative lesion sequencing provides insights into tumor evolution.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4283-8.
2008: Barber Thomas D; McManus Kirk; Yuen Karen W Y; Reis Marcelo; Parmigiani Giovanni; Shen Dong; Barrett Irene; Nouhi Yasaman; Spencer Forrest; Markowitz Sanford; Velculescu Victor E; Kinzler Kenneth W; Vogelstein Bert; Lengauer Christoph; Hieter Philip
Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3443-8.
2008: Segal Neil H; Parsons D Williams; Peggs Karl S; Velculescu Victor; Kinzler Ken W; Vogelstein Bert; Allison James P
Epitope landscape in breast and colorectal cancer.
Cancer research 2008;68(3):889-92.
2008: Velculescu Victor
The intersection of basic science and health policy: a conversation with Victor Velculescu. Interview by Barbara J. Culliton.
Health affairs (Project Hope) 2008;27(1):w27-33.
2008: Picelli Simone; Vandrovcova Jana; Jones Siân; Djureinovic Tatjana; Skoglund Johanna; Zhou Xiao-Lei; Velculescu Victor E; Vogelstein Bert; Lindblom Annika
Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q.
BMC cancer 2008;8():87.
2007: Huang Chuan-Hsiang; Mandelker Diana; Schmidt-Kittler Oleg; Samuels Yardena; Velculescu Victor E; Kinzler Kenneth W; Vogelstein Bert; Gabelli Sandra B; Amzel L Mario
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Science (New York, N.Y.) 2007;318(5857):1744-8.
2007: Beerenwinkel Niko; Antal Tibor; Dingli David; Traulsen Arne; Kinzler Kenneth W; Velculescu Victor E; Vogelstein Bert; Nowak Martin A
Genetic progression and the waiting time to cancer.
PLoS computational biology 2007;3(11):e225.
2007: Wood Laura D; Parsons D Williams; Jones Siân; Lin Jimmy; Sjöblom Tobias; Leary Rebecca J; Shen Dong; Boca Simina M; Barber Thomas; Ptak Janine; Silliman Natalie; Szabo Steve; Dezso Zoltan; Ustyanksky Vadim; Nikolskaya Tatiana; Nikolsky Yuri; Karchin Rachel; Wilson Paul A; Kaminker Joshua S; Zhang Zemin; Croshaw Randal; Willis Joseph; Dawson Dawn; Shipitsin Michail; Willson James K V; Sukumar Saraswati; Polyak Kornelia; Park Ben Ho; Pethiyagoda Charit L; Pant P V Krishna; Ballinger Dennis G; Sparks Andrew B; Hartigan James; Smith Douglas R; Suh Erick; Papadopoulos Nickolas; Buckhaults Phillip; Markowitz Sanford D; Parmigiani Giovanni; Kinzler Kenneth W; Velculescu Victor E; Vogelstein Bert
The genomic landscapes of human breast and colorectal cancers.
Science (New York, N.Y.) 2007;318(5853):1108-13.
2007: Rago Carlo; Huso David L; Diehl Frank; Karim Baktiar; Liu Guosheng; Papadopoulos Nickolas; Samuels Yardena; Velculescu Victor E; Vogelstein Bert; Kinzler Kenneth W; Diaz Luis A
Serial assessment of human tumor burdens in mice by the analysis of circulating DNA.
Cancer research 2007;67(19):9364-70.
2007: Lin Jimmy; Gan Christine M; Zhang Xiaosong; Jones Siân; Sjöblom Tobias; Wood Laura D; Parsons D Williams; Papadopoulos Nickolas; Kinzler Kenneth W; Vogelstein Bert; Parmigiani Giovanni; Velculescu Victor E
A multidimensional analysis of genes mutated in breast and colorectal cancers.
Genome research 2007;17(9):1304-18.
2007: Velculescu Victor E; Kinzler Kenneth W
Gene expression analysis goes digital.
Nature biotechnology 2007;25(8):878-80.
2007: Zhang Xiaodong; Guo Ailan; Yu Jianshi; Possemato Anthony; Chen Yueting; Zheng Weiping; Polakiewicz Roberto D; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E; Wang Zhenghe John
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4060-4.
2007: Peters Brock A; St Croix Brad; Sjöblom Tobias; Cummins Jordan M; Silliman Natalie; Ptak Janine; Saha Saurabh; Kinzler Kenneth W; Hatzis Christos; Velculescu Victor E
Large-scale identification of novel transcripts in the human genome.
Genome research 2007;17(3):287-92.
2007: Leary Rebecca J; Cummins Jordan; Wang Tian-Li; Velculescu Victor E
Digital karyotyping.
Nature protocols 2007;2(8):1973-86.
2006: Bettegowda Chetan; Huang Xin; Lin Jimmy; Cheong Ian; Kohli Manu; Szabo Stephen A; Zhang Xiaosong; Diaz Luis A; Velculescu Victor E; Parmigiani Giovanni; Kinzler Kenneth W; Vogelstein Bert; Zhou Shibin
The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT.
Nature biotechnology 2006;24(12):1573-80.
2006: Cummins J M; Velculescu V E
Implications of micro-RNA profiling for cancer diagnosis.
Oncogene 2006;25(46):6220-7.
2006: Sjöblom Tobias; Jones Siân; Wood Laura D; Parsons D Williams; Lin Jimmy; Barber Thomas D; Mandelker Diana; Leary Rebecca J; Ptak Janine; Silliman Natalie; Szabo Steve; Buckhaults Phillip; Farrell Christopher; Meeh Paul; Markowitz Sanford D; Willis Joseph; Dawson Dawn; Willson James K V; Gazdar Adi F; Hartigan James; Wu Leo; Liu Changsheng; Parmigiani Giovanni; Park Ben Ho; Bachman Kurtis E; Papadopoulos Nickolas; Vogelstein Bert; Kinzler Kenneth W; Velculescu Victor E
The consensus coding sequences of human breast and colorectal cancers.
Science (New York, N.Y.) 2006;314(5797):268-74.
2006: Wood Laura D; Calhoun Eric S; Silliman Natalie; Ptak Janine; Szabo Steve; Powell Steve M; Riggins Gregory J; Wang Tian-Li; Yan Hai; Gazdar Adi; Kern Scott E; Pennacchio Len; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.
Human mutation 2006;27(10):1060-1.
2006: Edkins Sarah; O'Meara Sarah; Parker Adrian; Stevens Claire; Reis Marcelo; Jones Siân; Greenman Chris; Davies Helen; Dalgliesh Gillian; Forbes Simon; Hunter Chris; Smith Raffaella; Stephens Philip; Goldstraw Peter; Nicholson Andrew; Chan Tsun Leung; Velculescu Victor E; Yuen Siu Tsan; Leung Suet Yi; Stratton Michael R; Futreal P Andrew
Recurrent KRAS codon 146 mutations in human colorectal cancer.
Cancer biology & therapy 2006;5(8):928-32.
2006: Nakayama Kentaro; Nakayama Naomi; Kurman Robert J; Cope Leslie; Pohl Gudrun; Samuels Yardena; Velculescu Victor E; Wang Tian-Li; Shih Ie-Ming
Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms.
Cancer biology & therapy 2006;5(7):779-85.
2006: Nakayama Kentaro; Nakayama Naomi; Davidson Ben; Katabuchi Hidetaka; Kurman Robert J; Velculescu Victor E; Shih Ie-Ming; Wang Tian-Li
Homozygous deletion of MKK4 in ovarian serous carcinoma.
Cancer biology & therapy 2006;5(6):630-4.
2006: Cummins Jordan M; He Yiping; Leary Rebecca J; Pagliarini Ray; Diaz Luis A; Sjoblom Tobias; Barad Omer; Bentwich Zvi; Szafranska Anna E; Labourier Emmanuel; Raymond Christopher K; Roberts Brian S; Juhl Hartmut; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
The colorectal microRNAome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3687-92.
2005: Parsons D Williams; Wang Tian-Li; Samuels Yardena; Bardelli Alberto; Cummins Jordan M; DeLong Laura; Silliman Natalie; Ptak Janine; Szabo Steve; Willson James K V; Markowitz Sanford; Kinzler Kenneth W; Vogelstein Bert; Lengauer Christoph; Velculescu Victor E
Colorectal cancer: mutations in a signalling pathway.
Nature 2005;436(7052):792.
2005: Hu Min; Yao Jun; Cai Li; Bachman Kurt E; van den Brûle Frédéric; Velculescu Victor; Polyak Kornelia
Distinct epigenetic changes in the stromal cells of breast cancers.
Nature genetics 2005;37(8):899-905.
2005: Samuels Yardena; Diaz Luis A; Schmidt-Kittler Oleg; Cummins Jordan M; Delong Laura; Cheong Ian; Rago Carlo; Huso David L; Lengauer Christoph; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Cancer cell 2005;7(6):561-73.
2005: Peters Brock A; Velculescu Victor E
Transcriptome PETs: a genome's best friends.
Nature methods 2005;2(2):93-4.
2005: Di Chunhui; Liao Shaoxi; Adamson David C; Parrett Timothy J; Broderick Daniel K; Shi Qun; Lengauer Christoph; Cummins Jordan M; Velculescu Victor E; Fults Daniel W; McLendon Roger E; Bigner Darell D; Yan Hai
Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid.
Cancer research 2005;65(3):919-24.
2005: Bardelli Alberto; Velculescu Victor E
Mutational analysis of gene families in human cancer.
Current opinion in genetics & development 2005;15(1):5-12.
2004: Barber Thomas D; Vogelstein Bert; Kinzler Kenneth W; Velculescu Victor E
Somatic mutations of EGFR in colorectal cancers and glioblastomas.
The New England journal of medicine 2004;351(27):2883.
2004: Bentires-Alj Mohamed; Paez J Guillermo; David Frank S; Keilhack Heike; Halmos Balazs; Naoki Katsuhiko; Maris John M; Richardson Andrea; Bardelli Alberto; Sugarbaker David J; Richards William G; Du Jinyan; Girard Luc; Minna John D; Loh Mignon L; Fisher David E; Velculescu Victor E; Vogelstein Bert; Meyerson Matthew; Sellers William R; Neel Benjamin G
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
Cancer research 2004;64(24):8816-20.
2004: Samuels Yardena; Velculescu Victor E
Oncogenic mutations of PIK3CA in human cancers.
Cell cycle (Georgetown, Tex.) 2004;3(10):1221-4.
2004: Broderick Daniel K; Di Chunhui; Parrett Timothy J; Samuels Yardena R; Cummins Jordan M; McLendon Roger E; Fults Daniel W; Velculescu Victor E; Bigner Darell D; Yan Hai
Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas.
Cancer research 2004;64(15):5048-50.
2004: Bachman Kurtis E; Argani Pedram; Samuels Yardena; Silliman Natalie; Ptak Janine; Szabo Steve; Konishi Hiroyuki; Karakas Bedri; Blair Brian G; Lin Clarence; Peters Brock A; Velculescu Victor E; Park Ben Ho
The PIK3CA gene is mutated with high frequency in human breast cancers.
Cancer biology & therapy 2004;3(8):772-5.
2004: Wang Zhenghe; Shen Dong; Parsons D Williams; Bardelli Alberto; Sager Jason; Szabo Steve; Ptak Janine; Silliman Natalie; Peters Brock A; van der Heijden Michiel S; Parmigiani Giovanni; Yan Hai; Wang Tian-Li; Riggins Greg; Powell Steven M; Willson James K V; Markowitz Sanford; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Science (New York, N.Y.) 2004;304(5674):1164-6.
2004: Wang Zhenghe; Cummins Jordan M; Shen Dong; Cahill Daniel P; Jallepalli Prasad V; Wang Tian-Li; Parsons D Williams; Traverso Giovanni; Awad Mark; Silliman Natalie; Ptak Janine; Szabo Steve; Willson James K V; Markowitz Sanford D; Goldberg Michael L; Karess Roger; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E; Lengauer Christoph
Three classes of genes mutated in colorectal cancers with chromosomal instability.
Cancer research 2004;64(9):2998-3001.
2004: Samuels Yardena; Wang Zhenghe; Bardelli Alberto; Silliman Natalie; Ptak Janine; Szabo Steve; Yan Hai; Gazdar Adi; Powell Steven M; Riggins Gregory J; Willson James K V; Markowitz Sanford; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
High frequency of mutations of the PIK3CA gene in human cancers.
Science (New York, N.Y.) 2004;304(5670):554.
2004: Rajagopalan Harith; Jallepalli Prasad V; Rago Carlo; Velculescu Victor E; Kinzler Kenneth W; Vogelstein Bert; Lengauer Christoph
Inactivation of hCDC4 can cause chromosomal instability.
Nature 2004;428(6978):77-81.
2004: Wang Tian-Li; Diaz Luis A; Romans Katharine; Bardelli Alberto; Saha Saurabh; Galizia Gennaro; Choti Michael; Donehower Ross; Parmigiani Giovanni; Shih Ie-Ming; Iacobuzio-Donahue Christine; Kinzler Kenneth W; Vogelstein Bert; Lengauer Christoph; Velculescu Victor E
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3089-94.
2003: Bardelli Alberto; Saha Saurabh; Sager Jason A; Romans Kathy E; Xin Baozhong; Markowitz Sanford D; Lengauer Christoph; Velculescu Victor E; Kinzler Kenneth W; Vogelstein Bert
PRL-3 expression in metastatic cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5607-15.
2003: Buckhaults Phillip; Zhang Zhen; Chen Yu-Chi; Wang Tian-Li; St Croix Brad; Saha Saurabh; Bardelli Alberto; Morin Patrice J; Polyak Kornelia; Hruban Ralph H; Velculescu Victor E; Shih Ie-Ming
Identifying tumor origin using a gene expression-based classification map.
Cancer research 2003;63(14):4144-9.
2003: Bardelli Alberto; Parsons D Williams; Silliman Natalie; Ptak Janine; Szabo Steve; Saha Saurabh; Markowitz Sanford; Willson James K V; Parmigiani Giovanni; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
Mutational analysis of the tyrosine kinome in colorectal cancers.
Science (New York, N.Y.) 2003;300(5621):949.
2002: Wang Tian-Li; Maierhofer Christine; Speicher Michael R; Lengauer Christoph; Vogelstein Bert; Kinzler Kenneth W; Velculescu Victor E
Digital karyotyping.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):16156-61.
2002: Rajagopalan Harith; Bardelli Alberto; Lengauer Christoph; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status.
Nature 2002;418(6901):934.
2002: Yan Hai; Yuan Weishi; Velculescu Victor E; Vogelstein Bert; Kinzler Kenneth W
Allelic variation in human gene expression.
Science (New York, N.Y.) 2002;297(5584):1143.
2002: Saha Saurabh; Sparks Andrew B; Rago Carlo; Akmaev Viatcheslav; Wang Clarence J; Vogelstein Bert; Kinzler Kenneth W; Velculescu Victor E
Using the transcriptome to annotate the genome.
Nature biotechnology 2002;20(5):508-12.
2002: Wang Tian-Li; Rago Carlo; Silliman Natalie; Ptak Janine; Markowitz Sanford; Willson James K V; Parmigiani Giovanni; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
Prevalence of somatic alterations in the colorectal cancer cell genome.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3076-80.
2001: Saha S; Bardelli A; Buckhaults P; Velculescu V E; Rago C; St Croix B; Romans K E; Choti M A; Lengauer C; Kinzler K W; Vogelstein B
A phosphatase associated with metastasis of colorectal cancer.
Science (New York, N.Y.) 2001;294(5545):1343-6.
2001: Jones S J; Riddle D L; Pouzyrev A T; Velculescu V E; Hillier L; Eddy S R; Stricklin S L; Baillie D L; Waterston R; Marra M A
Changes in gene expression associated with developmental arrest and longevity in Caenorhabditis elegans.
Genome research 2001;11(8):1346-52.
2001: Howe J R; Bair J L; Sayed M G; Anderson M E; Mitros F A; Petersen G M; Velculescu V E; Traverso G; Vogelstein B
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.
Nature genetics 2001;28(2):184-7.
2000: Velculescu V E; Vogelstein B; Kinzler K W
Analysing uncharted transcriptomes with SAGE.
Trends in genetics : TIG 2000;16(10):423-5.
2000: St Croix B; Rago C; Velculescu V; Traverso G; Romans K E; Montgomery E; Lal A; Riggins G J; Lengauer C; Vogelstein B; Kinzler K W
Genes expressed in human tumor endothelium.
Science (New York, N.Y.) 2000;289(5482):1197-202.
1999: Velculescu V E; Madden S L; Zhang L; Lash A E; Yu J; Rago C; Lal A; Wang C J; Beaudry G A; Ciriello K M; Cook B P; Dufault M R; Ferguson A T; Gao Y; He T C; Hermeking H; Hiraldo S K; Hwang P M; Lopez M A; Luderer H F; Mathews B; Petroziello J M; Polyak K; Zawel L; Kinzler K W
Analysis of human transcriptomes.
Nature genetics 1999;23(4):387-8.
1999: Velculescu V E
Essay: Amersham Pharmacia Biotech & Science prize. Tantalizing transcriptomes--SAGE and its use in global gene expression analysis.
Science (New York, N.Y.) 1999;286(5444):1491-2.
1999: Lal A; Lash A E; Altschul S F; Velculescu V; Zhang L; McLendon R E; Marra M A; Prange C; Morin P J; Polyak K; Papadopoulos N; Vogelstein B; Kinzler K W; Strausberg R L; Riggins G J
A public database for gene expression in human cancers.
Cancer research 1999;59(21):5403-7.
1999: Basrai M A; Velculescu V E; Kinzler K W; Hieter P
NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae.
Molecular and cellular biology 1999;19(10):7041-9.
1998: Zhou W; Sokoll L J; Bruzek D J; Zhang L; Velculescu V E; Goldin S B; Hruban R H; Kern S E; Hamilton S R; Chan D W; Vogelstein B; Kinzler K W
Identifying markers for pancreatic cancer by gene expression analysis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1998;7(2):109-12.
1997: Zhang L; Zhou W; Velculescu V E; Kern S E; Hruban R H; Hamilton S R; Vogelstein B; Kinzler K W
Gene expression profiles in normal and cancer cells.
Science (New York, N.Y.) 1997;276(5316):1268-72.
1997: Velculescu V E; Zhang L; Zhou W; Vogelstein J; Basrai M A; Bassett D E; Hieter P; Vogelstein B; Kinzler K W
Characterization of the yeast transcriptome.
Cell 1997;88(2):243-51.
1996: Velculescu V E; El-Deiry W S
Biological and clinical importance of the p53 tumor suppressor gene.
Clinical chemistry 1996;42(6 Pt 1):858-68.
1995: Velculescu V E; Zhang L; Vogelstein B; Kinzler K W
Serial analysis of gene expression.
Science (New York, N.Y.) 1995;270(5235):484-7.
1995: el-Deiry W S; Tokino T; Waldman T; Oliner J D; Velculescu V E; Burrell M; Hill D E; Healy E; Rees J L; Hamilton S R
Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.
Cancer research 1995;55(13):2910-9.
1994: Dintzis S M; Velculescu V E; Pfeffer S R
Receptor extracellular domains may contain trafficking information. Studies of the 300-kDa mannose 6-phosphate receptor.
The Journal of biological chemistry 1994;269(16):12159-66.
1994: el-Deiry W S; Harper J W; O'Connor P M; Velculescu V E; Canman C E; Jackman J; Pietenpol J A; Burrell M; Hill D E; Wang Y
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
Cancer research 1994;54(5):1169-74.
1993: el-Deiry W S; Tokino T; Velculescu V E; Levy D B; Parsons R; Trent J M; Lin D; Mercer W E; Kinzler K W; Vogelstein B
WAF1, a potential mediator of p53 tumor suppression.
Cell 1993;75(4):817-25.

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