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Johannes Veldhuis

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Johannes D Veldhuis
Changes in pituitary function with ageing and implications for patient care.
Johannes D Veldhuis; John M Miles; Catalina Norman; Cyril Y Bowers
Sex steroids, GHRH, somatostatin, IGF-I, and IGFBP-1 modulate ghrelin's dose-dependent drive of pulsatile GH secretion in healthy older men.
Johannes D Veldhuis; Suanne M Weist; Peter Y Liu; Paul Y Takahashi; Jean R Wigham
Analysis of the impact of intravenous LH pulses versus continuous LH infusion on testosterone secretion during GnRH-receptor blockade.

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All Publications

2013: Johannes D Veldhuis
Changes in pituitary function with ageing and implications for patient care.
Nature reviews. Endocrinology 2013;9(4):205-15.
2012: Johannes D Veldhuis; John M Miles; Catalina Norman; Cyril Y Bowers
Sex steroids, GHRH, somatostatin, IGF-I, and IGFBP-1 modulate ghrelin's dose-dependent drive of pulsatile GH secretion in healthy older men.
The Journal of clinical endocrinology and metabolism 2012;97(12):4753-60.
2012: Johannes D Veldhuis; Suanne M Weist; Peter Y Liu; Paul Y Takahashi; Jean R Wigham
Analysis of the impact of intravenous LH pulses versus continuous LH infusion on testosterone secretion during GnRH-receptor blockade.
American journal of physiology. Regulatory, integrative and comparative physiology 2012;303(10):R994-R1002.
2012: Ferdinand Roelfsema; Daniel M Keenan; Hanno Pijl; Johannes D Veldhuis
Diminished adrenal sensitivity and ACTH efficacy in obese premenopausal women.
European journal of endocrinology / European Federation of Endocrine Societies 2012;167(5):633-42.
2012: Johannes D Veldhuis; Peter Y Liu; Paul Y Takahashi; Daniel M Keenan
Dynamic testosterone responses to near-physiological LH pulses are determined by the time pattern of prior intravenous LH infusion.
American journal of physiology. Endocrinology and metabolism 2012;303(6):E720-8.
2012: Daniel M Keenan; Yan Liu; Ananda Basu; Rita Basu; Gerlies Bock; Johannes D Veldhuis
Logistic model of glucose-regulated C-peptide secretion: hysteresis pathway disruption in impaired fasting glycemia.
American journal of physiology. Endocrinology and metabolism 2012;303(3):E397-409.
2012: Jeremy T Smith; Johannes D Veldhuis; I Ross Young; Iain J Clarke
Gonadotropin-inhibitory hormone (GnIH) secretion into the ovine hypophyseal portal system.
Endocrinology 2012;153(7):3368-75.
2012: Ali Iranmanesh; Donna Lawson; Johannes D Veldhuis
Distinct metabolic surrogates predict basal and rebound GH secretion after glucose ingestion in men.
The Journal of clinical endocrinology and metabolism 2012;97(6):2172-9.
2012: Stefan Rohrer; Wolfgang E Schmidt; Johannes D Veldhuis; Björn A Menge; Carolyn F Deacon; Lena Grüber; Jens J Holst; Juris J Meier
Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals.
The Journal of clinical endocrinology and metabolism 2012;97(5):E791-5.
2012: Ali Iranmanesh; Donna Lawson; Johannes D Veldhuis
Glucose ingestion acutely lowers pulsatile LH and basal testosterone secretion in men.
American journal of physiology. Endocrinology and metabolism 2012;302(6):E724-30.
2012: Johannes D Veldhuis; Daniel M Keenan
Model-based evaluation of growth hormone secretion.
Methods in enzymology 2012;514():231-48.
2012: Ferdinand Roelfsema; Daniel M Keenan; Hanno Pijl; Johannes D Veldhuis
Prolactin secretion in healthy adults is determined by gender, age and body mass index.
PloS one 2012;7(2):e31305.
2011: Daniel M Keenan; Iain J Clarke; Johannes D Veldhuis
Noninvasive analytical estimation of endogenous GnRH drive: analysis using graded competitive GnRH-receptor antagonism and a calibrating pulse of exogenous GnRH.
Endocrinology 2011;152(12):4882-93.
2011: Ferdinand Roelfsema; Daniel M Keenan; Johannes D Veldhuis
Endogenous ACTH concentration-cortisol secretion dose analysis unmasks decreased ACTH potency in Cushing's disease with restoration after successful pituitary adenomectomy.
The Journal of clinical endocrinology and metabolism 2011;96(12):3768-74.
2011: Xin Wang; Daniel M Keenan; Peter Y Liu; Steven M Pincus; Johannes D Veldhuis
Oscillations in joint synchrony of reproductive hormones in healthy men.
American journal of physiology. Endocrinology and metabolism 2011;301(6):E1163-73.
2011: Ali Iranmanesh; Jing Liu; Dudley F Rochester; Johannes D Veldhuis
Impaired adrenergic- and corticotropic-axis outflow during exercise in chronic obstructive pulmonary disease.
Metabolism: clinical and experimental 2011;60(11):1521-9.
2011: Ali Iranmanesh; Daniel M Keenan; Paul Aoun; Johannes D Veldhuis
Overnight ACTH-cortisol dose responsiveness: comparison with 24-h data, metyrapone administration and insulin-tolerance test in healthy adults.
Clinical endocrinology 2011;75(5):596-601.
2011: Johannes D Veldhuis; Cyril Y Bowers
Regulated recovery of pulsatile growth hormone secretion from negative feedback: a preclinical investigation.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;301(4):R1143-52.
2011: Ali Iranmanesh; Donna Lawson; Barbara Dunn; Johannes D Veldhuis
Glucose ingestion selectively amplifies ACTH and cortisol secretory-burst mass and enhances their joint synchrony in healthy men.
The Journal of clinical endocrinology and metabolism 2011;96(9):2882-8.
2011: Johannes D Veldhuis; Paul Aoun; Ali Iranmanesh; John M Miles; Ferdinand Roelfsema; Paul Y Takahashi; Daniel M Keenan
Tripartite control of dynamic ACTH-cortisol dose responsiveness by age, body mass index, and gender in 111 healthy adults.
The Journal of clinical endocrinology and metabolism 2011;96(9):2874-81.
2011: Ferdinand Roelfsema; Johannes D Veldhuis; Petra Kok; Hanno Pijl
Altered multihormone synchrony in obese patients with polycystic ovary syndrome.
Metabolism: clinical and experimental 2011;60(9):1227-33.
2011: Björn A Menge; Wolfgang E Schmidt; Johannes D Veldhuis; Carolyn F Deacon; Lena Grüber; Jens J Holst; Signe M Jørgensen; Juris J Meier
Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes.
Diabetes 2011;60(8):2160-8.
2011: Johannes D Veldhuis; Sue Weist; Jean Wigham; Dana Erickson; John M Miles; Cyril Y Bowers
Gender, sex-steroid, and secretagogue-selective recovery from growth hormone-induced feedback in older women and men.
The Journal of clinical endocrinology and metabolism 2011;96(8):2540-7.
2011: Johannes D Veldhuis; Dana Erickson; John M Miles; Cyril Y Bowers
Complex regulation of GH autofeedback under dual-peptide drive: studies under a pharmacological GH and sex steroid clamp.
American journal of physiology. Endocrinology and metabolism 2011;300(6):E1158-65.
2011: Daniel M Keenan; Ali Iranmanesh; Johannes D Veldhuis
Analytical construct of reversible desensitization of pituitary-testicular signaling: illustrative application in aging.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;300(2):R349-60.
2011: Johannes D Veldhuis; Ferdinand Roelfsema; Daniel M Keenan; Steven Pincus
Gender, age, body mass index, and IGF-I individually and jointly determine distinct GH dynamics: analyses in one hundred healthy adults.
The Journal of clinical endocrinology and metabolism 2011;96(1):115-21.
2010: Ranganath Muniyappa; Johannes D Veldhuis; S Mitchell Harman; John D Sorkin; Marc R Blackman
Effects of testosterone administration on nocturnal cortisol secretion in healthy older men.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(11):1185-92.
2010: Johannes D Veldhuis; Paul Y Takahashi; Daniel M Keenan; Peter Y Liu; Kristi L Mielke; Suanne M Weist
Age disrupts androgen receptor-modulated negative feedback in the gonadal axis in healthy men.
American journal of physiology. Endocrinology and metabolism 2010;299(4):E675-82.
2010: Johannes D Veldhuis; Martin Bidlingmaier; Joy Bailey; Dana Erickson; Paola Sandroni
A pegylated growth hormone receptor antagonist, pegvisomant, does not enter the brain in humans.
The Journal of clinical endocrinology and metabolism 2010;95(8):3844-7.
2010: Daniel M Keenan; Ferdinand Roelfsema; Johannes D Veldhuis
Dose-response downregulation within the span of single interpulse intervals.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;299(1):R11-8.
2010: Ali Iranmanesh; Thomas Mulligan; Johannes D Veldhuis
Age in men does not determine gonadotropin-releasing hormone's dose-dependent stimulation of luteinizing hormone secretion under an exogenous testosterone clamp.
The Journal of clinical endocrinology and metabolism 2010;95(6):2877-84.
2010: Ali Iranmanesh; Cyril Y Bowers; Johannes D Veldhuis
Secretagogue type, sex-steroid milieu, and abdominal visceral adiposity individually determine secretagogue-stimulated cortisol secretion.
European journal of endocrinology / European Federation of Endocrine Societies 2010;162(6):1043-9.
2010: Georgina M Russell; David E Henley; Jack Leendertz; Jennie A Douthwaite; Susan A Wood; Adam Stevens; Wolfram W Woltersdorf; Bernard W M M Peeters; Ge S F Ruigt; Anne White; Johannes D Veldhuis; Stafford L Lightman
Rapid glucocorticoid receptor-mediated inhibition of hypothalamic-pituitary-adrenal ultradian activity in healthy males.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(17):6106-15.
2010: Geert Meyfroidt; Daniel M Keenan; Xin Wang; Pieter J Wouters; Johannes D Veldhuis; Greet Van den Berghe
Dynamic characteristics of blood glucose time series during the course of critical illness: effects of intensive insulin therapy and relative association with mortality.
Critical care medicine 2010;38(4):1021-9.
2010: Johannes D Veldhuis; Daniel M Keenan; Peter Y Liu; Paul Y Takahashi
Kinetics of removal of intravenous testosterone pulses in normal men.
European journal of endocrinology / European Federation of Endocrine Societies 2010;162(4):787-94.
2010: Stanislaw Niemczyk; Hanna Sikorska; Andrzej Wiecek; Ewa Zukowska-Szczechowska; Klaudia Załecka; Joanna Gorczyńska; Małgorzata Kubik; Beata Czerwieńska; Katarzyna Gosek; Johannes D Veldhuis; David A Wagner; Pierrette Gaudreau; Tiina Hakonen; Sam Wai Kit Kay; Taneli Jouhikainen; Franz Schaefer
A super-agonist of growth hormone-releasing hormone causes rapid improvement of nutritional status in patients with chronic kidney disease.
Kidney international 2010;77(5):450-8.
2010: Ferdinand Roelfsema; Alberto M Pereira; Ria Adriaanse; Erik Endert; Eric Fliers; Johannes A Romijn; Johannes D Veldhuis
Thyrotropin secretion in mild and severe primary hypothyroidism is distinguished by amplified burst mass and Basal secretion with increased spikiness and approximate entropy.
The Journal of clinical endocrinology and metabolism 2010;95(2):928-34.
2010: Leanne M Redman; Johannes D Veldhuis; Jennifer Rood; Steven R Smith; Donald A Williamson; Eric Ravussin
The effect of caloric restriction interventions on growth hormone secretion in nonobese men and women.
Aging cell 2010;9(1):32-9.
2010: Johannes D Veldhuis; Cyril Y Bowers
Integrating GHS into the Ghrelin System.
International journal of peptides 2010;2010():.
2010: Johannes D Veldhuis; Daniel M Keenan; Steven M Pincus
Regulation of complex pulsatile and rhythmic neuroendocrine systems: the male gonadal axis as a prototype.
Progress in brain research 2010;181():79-110.
2010: Susan B Hudson; Darrell R Schroeder; Joy N Bailey; Kristi Mielke; Dana Erickson; John M Miles; Cyril Y Bowers; Johannes D Veldhuis
Pre- versus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: studies using submaximal agonist drive and an estrogen clamp.
The Journal of clinical endocrinology and metabolism 2010;95(1):353-60.
2009: Ferdinand Roelfsema; Alberto M Pereira; Nienke R Biermasz; Marijke Frolich; Daniel M Keenan; Johannes D Veldhuis; Johannes A Romijn
Diminished and irregular TSH secretion with delayed acrophase in patients with Cushing's syndrome.
European journal of endocrinology / European Federation of Endocrine Societies 2009;161(5):695-703.
2009: Daniel M Keenan; Johannes D Veldhuis
Age-dependent regression analysis of male gonadal axis.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;297(5):R1215-27.
2009: Ferdinand Roelfsema; Alberto M Pereira; Johannes D Veldhuis; Ria Adriaanse; Erik Endert; Eric Fliers; Johannes A Romijn
Thyrotropin secretion profiles are not different in men and women.
The Journal of clinical endocrinology and metabolism 2009;94(10):3964-7.
2009: Johannes D Veldhuis; Ferdinand Roelfsema; Ali Iranmanesh; Bernard J Carroll; Daniel M Keenan; Steven M Pincus
Basal, pulsatile, entropic (patterned), and spiky (staccato-like) properties of ACTH secretion: impact of age, gender, and body mass index.
The Journal of clinical endocrinology and metabolism 2009;94(10):4045-52.
2009: Peter Y Liu; Paul Y Takahashi; Pamela D Roebuck; Joy N Bailey; Daniel M Keenan; Johannes D Veldhuis
Testosterone's short-term positive effect on luteinizing-hormone secretory-burst mass and its negative effect on secretory-burst frequency are attenuated in middle-aged men.
The Journal of clinical endocrinology and metabolism 2009;94(10):3978-86.
2009: María Gabriela Ropelato; María Cecilia García Rudaz; María Eugenia Escobar; Sonia Viviana Bengolea; María Luján Calcagno; Johannes D Veldhuis; Marta Barontini
Acute effects of testosterone infusion on the serum luteinizing hormone profile in eumenorrheic and polycystic ovary syndrome adolescents.
The Journal of clinical endocrinology and metabolism 2009;94(9):3602-10.
2009: Daniel M Keenan; Ferdinand Roelfsema; Bernard J Carroll; Ali Iranmanesh; Johannes D Veldhuis
Sex defines the age dependence of endogenous ACTH-cortisol dose responsiveness.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;297(2):R515-23.
2009: Peter Y Liu; Daniel M Keenan; Petra Kok; Vasantha Padmanabhan; Kevin T O'Byrne; Johannes D Veldhuis
Sensitivity and specificity of pulse detection using a new deconvolution method.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E538-44.
2009: Johannes D Veldhuis; Susan A Hudson; Joy N Bailey; Dana Erickson
Regulation of basal, pulsatile, and entropic (patterned) modes of GH secretion in a putatively low-somatostatin milieu in women.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E483-9.
2009: Johannes D Veldhuis; Susan B Hudson; Dana Erickson; Joy N Bailey; George Ann Reynolds; Cyril Y Bowers
Relative effects of estrogen, age, and visceral fat on pulsatile growth hormone secretion in healthy women.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E367-74.
2009: Johannes D Veldhuis; Daniel M Keenan; Joy N Bailey; John M Miles; Cyril Y Bowers
Preservation of GHRH and GH-releasing peptide-2 efficacy in young men with experimentally induced hypogonadism.
European journal of endocrinology / European Federation of Endocrine Societies 2009;161(2):293-300.
2009: Johannes D Veldhuis; Cyril Y Bowers
Factors other than sex steroids modulate GHRH and GHRP-2 efficacies in men: evaluation using a GnRH agonist/testosterone clamp.
The Journal of clinical endocrinology and metabolism 2009;94(7):2544-50.
2009: Johannes D Veldhuis; Daniel M Keenan; Joy N Bailey; Adebordurin M Adeniji; John M Miles; Cyril Y Bowers
Novel relationships of age, visceral adiposity, insulin-like growth factor (IGF)-I and IGF binding protein concentrations to growth hormone (GH) releasing-hormone and GH releasing-peptide efficacies in men during experimental hypogonadal clamp.
The Journal of clinical endocrinology and metabolism 2009;94(6):2137-43.
2009: Ferdinand Roelfsema; Nienke R Biermasz; Marijke Frolich; Daniel M Keenan; Johannes D Veldhuis; Johannes A Romijn
Diminished and irregular thyrotropin secretion with preserved diurnal rhythm in patients with active acromegaly.
The Journal of clinical endocrinology and metabolism 2009;94(6):1945-50.
2009: Johannes D Veldhuis; Cyril Y Bowers
Determinants of GH-releasing hormone and GH-releasing peptide synergy in men.
American journal of physiology. Endocrinology and metabolism 2009;296(5):E1085-92.
2009: Daniel M Keenan; Sue Alexander; C H G Irvine; Johannes D Veldhuis
Quantifying nonlinear interactions within the hypothalamo-pituitary-adrenal axis in the conscious horse.
Endocrinology 2009;150(4):1941-51.
2009: Johannes D Veldhuis; Kristi Mielke; Mihaela Cosma; Cacia Soares-Welch; Remberto Paulo; John M Miles; Cyril Y Bowers
Aromatase and 5alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex steroid modulation of somatostatin and growth hormone secretagogue actions in healthy older men.
The Journal of clinical endocrinology and metabolism 2009;94(3):973-81.
2009: Johannes D Veldhuis; Daniel M Keenan; Peter Y Liu; Ali Iranmanesh; Paul Y Takahashi; Ajay X Nehra
The aging male hypothalamic-pituitary-gonadal axis: pulsatility and feedback.
Molecular and cellular endocrinology 2009;299(1):14-22.
2009: Ferdinand Roelfsema; Simon Kok; Petra Kok; Alberto M Pereira; Nienke R Biermasz; Jan W A Smit; Marijke Frolich; Daniel M Keenan; Johannes D Veldhuis; Johannes A Romijn
Pituitary-hormone secretion by thyrotropinomas.
Pituitary 2009;12(3):200-10.
2009: Johannes D Veldhuis; Daniel M Keenan; Joy N Bailey; Adenborduin Adeniji; John M Miles; Remberto Paulo; Mihaela Cosma; Cacia Soares-Welch
Testosterone supplementation in older men restrains insulin-like growth factor's dose-dependent feedback inhibition of pulsatile growth hormone secretion.
The Journal of clinical endocrinology and metabolism 2009;94(1):246-54.
2008: Johannes D Veldhuis; Daniel M Keenan; Steven M Pincus
Motivations and methods for analyzing pulsatile hormone secretion.
Endocrine reviews 2008;29(7):823-64.
2008: Arthur Weltman; Judy Y Weltman; Dee Dee Watson Winfield; Kirsten Frick; James T Patrie; Petra Kok; Daniel M Keenan; Glenn A Gaesser; Johannes D Veldhuis
Effects of continuous versus intermittent exercise, obesity, and gender on growth hormone secretion.
The Journal of clinical endocrinology and metabolism 2008;93(12):4711-20.
2008: Johannes D Veldhuis; Daniel M Keenan; Joy N Bailey; Adenborduin Adeniji; John M Miles; Remberto Paulo; Mihaela Cosma; Cacia Soares-Welch
Estradiol supplementation in postmenopausal women attenuates suppression of pulsatile growth hormone secretion by recombinant human insulin-like growth factor type I.
The Journal of clinical endocrinology and metabolism 2008;93(11):4471-8.
2008: Ali Iranmanesh; Johannes D Veldhuis
Hypocortisolemic clamp unmasks jointly feedforward- and feedback-dependent control of overnight ACTH secretion.
European journal of endocrinology / European Federation of Endocrine Societies 2008;159(5):561-8.
2008: Johannes D Veldhuis; Daniel M Keenan
Secretagogues govern GH secretory-burst waveform and mass in healthy eugonadal and short-term hypogonadal men.
European journal of endocrinology / European Federation of Endocrine Societies 2008;159(5):547-54.
2008: Remberto Paulo; Richard Brundage; Mihaela Cosma; Kristi Mielke; Cyril Y Bowers; Johannes D Veldhuis
Estrogen elevates the peak overnight production rate of acylated ghrelin.
The Journal of clinical endocrinology and metabolism 2008;93(11):4440-7.
2008: Ferdinand Roelfsema; Alberto M Pereira; Daniel M Keenan; Johannes D Veldhuis; Johannes A Romijn
Thyrotropin secretion by thyrotropinomas is characterized by increased pulse frequency, delayed diurnal rhythm, enhanced basal secretion, spikiness, and disorderliness.
The Journal of clinical endocrinology and metabolism 2008;93(10):4052-7.
2008: Aleksey V Matveyenko; Johannes D Veldhuis; Peter C Butler
Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and beta-cell mass to age-related insulin resistance in rats.
American journal of physiology. Endocrinology and metabolism 2008;295(4):E832-41.
2008: Petra Kok; Remberto Paulo; Mihaela Cosma; Kristi Mielke; John M Miles; Cyril Y Bowers; Johannes D Veldhuis
Estrogen supplementation selectively enhances hypothalamo-pituitary sensitivity to ghrelin in postmenopausal women.
The Journal of clinical endocrinology and metabolism 2008;93(10):4020-6.
2008: Johannes D Veldhuis; George Ann Reynolds; Ali Iranmanesh; Cyril Y Bowers
Twenty-four hour continuous ghrelin infusion augments physiologically pulsatile, nycthemeral, and entropic (feedback-regulated) modes of growth hormone secretion.
The Journal of clinical endocrinology and metabolism 2008;93(9):3597-603.
2008: Aleksey V Matveyenko; Johannes D Veldhuis; Peter C Butler
Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal vein.
American journal of physiology. Endocrinology and metabolism 2008;295(3):E569-74.
2008: Johannes D Veldhuis
Aging and hormones of the hypothalamo-pituitary axis: gonadotropic axis in men and somatotropic axes in men and women.
Ageing research reviews 2008;7(3):189-208.
2008: Richard J Krieg; Johannes D Veldhuis; Barbara A Thornhill; Robert L Chevalier; Gregorio Gil
Growth hormone (GH) secretion, GH-dependent gene expression, and sexually dimorphic body growth in young rats with chronic renal failure.
Endocrine 2008;33(3):323-30.
2008: Debra L Waters; Clifford R Qualls; Richard I Dorin; Johannes D Veldhuis; Richard Baumgartner
Altered growth hormone, cortisol, and leptin secretion in healthy elderly persons with sarcopenia and mixed body composition phenotypes.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(5):536-41.
2008: Mihaela Cosma; Joy Bailey; John M Miles; Cyril Y Bowers; Johannes D Veldhuis
Pituitary and/or peripheral estrogen-receptor alpha regulates follicle-stimulating hormone secretion, whereas central estrogenic pathways direct growth hormone and prolactin secretion in postmenopausal women.
The Journal of clinical endocrinology and metabolism 2008;93(3):951-8.
2008: Remberto Paulo; Mihaela Cosma; Cacia Soares-Welch; Joy N Bailey; Kristi Mielke; John M Miles; Cyril Y Bowers; Johannes D Veldhuis
Gonadal status and body mass index jointly determine growth hormone (GH)-releasing hormone/GH-releasing peptide synergy in healthy men.
The Journal of clinical endocrinology and metabolism 2008;93(3):944-50.
2008: Sekar Natesampillai; Jason Kerkvliet; Peter C K Leung; Johannes D Veldhuis
Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells.
American journal of physiology. Endocrinology and metabolism 2008;294(2):E385-91.
2008: Cyril Y Bowers; George R Merriam; Johannes D Veldhuis
Validation of growth-hormone-releasing peptide 2 for the diagnosis of adult growth hormone deficiency.
Nature clinical practice. Endocrinology & metabolism 2008;4(2):68-9.
2007: Peter Y Liu; Ali Iranmanesh; Daniel M Keenan; Steven M Pincus; Johannes D Veldhuis
A noninvasive measure of negative-feedback strength, approximate entropy, unmasks strong diurnal variations in the regularity of LH secretion.
American journal of physiology. Endocrinology and metabolism 2007;293(5):E1409-15.
2007: Johannes D Veldhuis; Daniel M Keenan; Cyril Y Bowers
Peripheral estrogen receptor-alpha selectively modulates the waveform of GH secretory bursts in healthy women.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(4):R1514-21.
2007: Paul Y Takahashi; Patrick Votruba; Mohammed Abu-Rub; Kristi Mielke; Johannes D Veldhuis
Age attenuates testosterone secretion driven by amplitude-varying pulses of recombinant human luteinizing hormone during acute gonadotrope inhibition in healthy men.
The Journal of clinical endocrinology and metabolism 2007;92(9):3626-32.
2007: Ali Iranmanesh; Paul C Carpenter; Kristi Mielke; Cyril Y Bowers; Johannes D Veldhuis
Putative somatostatin suppression potentiates adrenocorticotropin secretion driven by ghrelin and human corticotropin-releasing hormone.
The Journal of clinical endocrinology and metabolism 2007;92(9):3653-9.
2007: Ranganath Muniyappa; John D Sorkin; Johannes D Veldhuis; S Mitchell Harman; Thomas Münzer; Shalender Bhasin; Marc R Blackman
Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men.
American journal of physiology. Endocrinology and metabolism 2007;293(3):E769-75.
2007: Johannes D Veldhuis; Daniel M Keenan; Cyril Y Bowers
Estimation of the size and shape of GH secretory bursts in healthy women using a physiological estradiol clamp and variable-waveform deconvolution model.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(3):R1013-21.
2007: Johannes D Veldhuis; Mihaela Cosma; Dana Erickson; Remberto Paulo; Kristi Mielke; Leon S Farhy; Cyril Y Bowers
Tripartite control of growth hormone secretion in women during controlled estradiol repletion.
The Journal of clinical endocrinology and metabolism 2007;92(6):2336-45.
2007: Agatha A van der Klaauw; Alberto M Pereira; Sjoerd W van Thiel; Marijke Frolich; A Iranmanesh; Johannes D Veldhuis; Ferdinand Roelfsema; Johannes A Romijn
Attenuated pulse size, disorderly growth hormone and prolactin secretion with preserved nyctohemeral rhythm distinguish irradiated from surgically treated acromegaly patients.
Clinical endocrinology 2007;66(4):489-98.
2007: Leon S Farhy; Cyril Y Bowers; Johannes D Veldhuis
Model-projected mechanistic bases for sex differences in growth hormone regulation in humans.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(4):R1577-93.
2007: María Eugenia Escobar; María Gabriela Ropelato; María Gabriela Ballerini; Mirta Graciela Gryngarten; María Cecilia García Rudaz; Johannes D Veldhuis; Marta Barontini
Acceleration of luteinizing hormone pulse frequency in adolescent girls with a history of central precocious puberty with versus without hyperandrogenism.
Hormone research 2007;68(6):278-85.
2007: Robert A Ritzel; Juris J Meier; Chia-Yu Lin; Johannes D Veldhuis; Peter C Butler
Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.
Diabetes 2007;56(1):65-71.
2006: Peter Y Liu; Paul Y Takahashi; Pamela D Roebuck; Johannes D Veldhuis
Age or factors associated with aging attenuate testosterone's concentration-dependent enhancement of the regularity of luteinizing hormone secretion in healthy men.
The Journal of clinical endocrinology and metabolism 2006;91(10):4077-84.
2006: Johannes D Veldhuis; Daniel M Keenan; Ali Iranmanesh; Kristi Mielke; John M Miles; Cyril Y Bowers
Estradiol potentiates ghrelin-stimulated pulsatile growth hormone secretion in postmenopausal women.
The Journal of clinical endocrinology and metabolism 2006;91(9):3559-65.
2006: Aleksey V Matveyenko; Johannes D Veldhuis; Peter C Butler
Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy.
Diabetes 2006;55(8):2347-56.
2006: Juris J Meier; Irene Hong-McAtee; Ryan Galasso; Johannes D Veldhuis; Antoinette Moran; Bernhard J Hering; Peter C Butler
Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver.
Diabetes 2006;55(8):2324-32.
2006: Celina Franco; Johannes D Veldhuis; Ali Iranmanesh; John Brandberg; Lars Lönn; Björn Andersson; Bengt-Ake Bengtsson; Johan Svensson; Gudmundur Johannsson
Thigh intermuscular fat is inversely associated with spontaneous GH release in post-menopausal women with abdominal obesity.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(2):261-8.
2006: Dorte Glintborg; Anne Pernille Hermann; Marianne Andersen; Claus Hagen; Henning Beck-Nielsen; Johannes D Veldhuis; Jan Erik Henriksen
Effect of pioglitazone on glucose metabolism and luteinizing hormone secretion in women with polycystic ovary syndrome.
Fertility and sterility 2006;86(2):385-97.
2006: Graydon S Meneilly; Johannes D Veldhuis; Dariush Elahi
Pulsatile insulin secretion in elderly patients with diabetes.
Diabetes research and clinical practice 2006;73(2):218-20.
2006: Johan Svensson; Gudmundur Johannsson; Ali Iranmanesh; Kerstin Albertsson-Wikland; Johannes D Veldhuis; Bengt-Ake Bengtsson
GH secretory pattern in young adults who discontinued GH treatment for GH deficiency and decreased longitudinal growth in childhood.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(1):91-9.
2006: Alfredo Ulloa-Aguirre; Lesly Portocarrero; Teresa Zariñán; Aleida Olivares; Sebastián Carranza-Lira; Johannes D Veldhuis; Juan Carlos López-Alvarenga
Effects of metformin on inappropriate LH release in women with polycystic ovarian syndrome and insulin resistance.
Reproductive biomedicine online 2006;12(6):669-83.
2006: Agatha A van der Klaauw; Alberto M Pereira; Sjoerd W van Thiel; Jan W A Smit; E P M Corssmit; Nienke R Biermasz; Marijke Frolich; A Iranmanesh; Johannes D Veldhuis; Ferdinand Roelfsema; Johannes A Romijn
GH deficiency in patients irradiated for acromegaly: significance of GH stimulatory tests in relation to the 24 h GH secretion.
European journal of endocrinology / European Federation of Endocrine Societies 2006;154(6):851-8.
2006: Gherardo Mazziotti; Vincenzo Cimino; Ernesto De Menis; Stefania Bonadonna; Giovanna Bugari; Laura De Marinis; Johannes D Veldhuis; Andrea Giustina
Active acromegaly enhances spontaneous parathyroid hormone pulsatility.
Metabolism: clinical and experimental 2006;55(6):736-40.
2006: Johannes D Veldhuis; Ali Iranmanesh; Kristi Mielke; John M Miles; Paul C Carpenter; Cyril Y Bowers
Ghrelin potentiates growth hormone secretion driven by putative somatostatin withdrawal and resists inhibition by human corticotropin-releasing hormone.
The Journal of clinical endocrinology and metabolism 2006;91(6):2441-6.
2006: Daniel M Keenan; Paul Y Takahashi; Peter Y Liu; Pamela D Roebuck; Ajay X Nehra; Ali Iranmanesh; Johannes D Veldhuis
An ensemble model of the male gonadal axis: illustrative application in aging men.
Endocrinology 2006;147(6):2817-28.
2006: Elizabeth A Young; Johannes D Veldhuis
Disordered adrenocorticotropin secretion in women with major depression.
The Journal of clinical endocrinology and metabolism 2006;91(5):1924-8.
2006: Arthur Weltman; Judy Y Weltman; Cathy Pritzlaff Roy; Laurie Wideman; James T Patrie; William S Evans; Johannes D Veldhuis
Growth hormone response to graded exercise intensities is attenuated and the gender difference abolished in older adults.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;100(5):1623-9.
2006: Juris J Meier; Lise L Kjems; Johannes D Veldhuis; Pierre Lefèbvre; Peter C Butler
Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis.
Diabetes 2006;55(4):1051-6.
2006: Johannes D Veldhuis; James N Roemmich; Erick J Richmond; Cyril Y Bowers
Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition.
Endocrine reviews 2006;27(2):101-40.
2006: Robert A Ritzel; Johannes D Veldhuis; Peter C Butler
The mass, but not the frequency, of insulin secretory bursts in isolated human islets is entrained by oscillatory glucose exposure.
American journal of physiology. Endocrinology and metabolism 2006;290(4):E750-6.
2006: Jacalyn J Robert McComb; Xu-Ping Qian; Johannes D Veldhuis; John J McGlone; Reid L Norman
Neuroendocrine responses to psychological stress in eumenorrheic and oligomenorrheic women.
Stress (Amsterdam, Netherlands) 2006;9(1):41-51.
2006: Robert A Ritzel; Alexandra E Butler; Robert A Rizza; Johannes D Veldhuis; Peter C Butler
Relationship between beta-cell mass and fasting blood glucose concentration in humans.
Diabetes care 2006;29(3):717-8.
2006: Sekar Natesampillai; Martin E Fernandez Zapico; Raul Urrutia; Johannes D Veldhuis
A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function.
The Journal of biological chemistry 2006;281(6):3040-7.
2006: Peter Y Liu; Steven M Pincus; Paul Y Takahashi; Pamela D Roebuck; Ali Iranmanesh; Daniel M Keenan; Johannes D Veldhuis
Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade.
American journal of physiology. Endocrinology and metabolism 2006;290(1):E34-E41.
2005: Johannes D Veldhuis; Daniel M Keenan; Ferdinand Roelfsema; Ali Iranmanesh
Aging-related adaptations in the corticotropic axis: modulation by gender.
Endocrinology and metabolism clinics of North America 2005;34(4):993-1014, x-xi.
2005: Peter Y Liu; Ali Iranmanesh; Ajay X Nehra; Daniel M Keenan; Johannes D Veldhuis
Mechanisms of hypoandrogenemia in healthy aging men.
Endocrinology and metabolism clinics of North America 2005;34(4):935-55, ix.
2005: Johannes D Veldhuis; Dana Erickson; Ali Iranmanesh; John M Miles; Cyril Y Bowers
Sex-steroid control of the aging somatotropic axis.
Endocrinology and metabolism clinics of North America 2005;34(4):877-93, viii.
2005: Ali Iranmanesh; Johannes D Veldhuis
Utility of ultrasensitive growth hormone assays in assessing aging-related hyposomatotropism.
Endocrinology and metabolism clinics of North America 2005;34(4):853-64, vii-viii.
2005: Johannes D Veldhuis; James M Patrie; Kirsten Frick; Judy Y Weltman; Arthur Weltman
Administration of recombinant human GHRH-1,44-amide for 3 months reduces abdominal visceral fat mass and increases physical performance measures in postmenopausal women.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(5):669-77.
2005: Graydon S Meneilly; Johannes D Veldhuis; Dariush Elahi
Deconvolution analysis of rapid insulin pulses before and after six weeks of continuous subcutaneous administration of glucagon-like peptide-1 in elderly patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2005;90(11):6251-6.
2005: Johannes D Veldhuis; Dana Erickson; Kristi Mielke; Leon S Farhy; Daniel M Keenan; Cyril Y Bowers
Distinctive inhibitory mechanisms of age and relative visceral adiposity on growth hormone secretion in pre- and postmenopausal women studied under a hypogonadal clamp.
The Journal of clinical endocrinology and metabolism 2005;90(11):6006-13.
2005: Daniel M Keenan; Somesh Chattopadhyay; Johannes D Veldhuis
Composite model of time-varying appearance and disappearance of neurohormone pulse signals in blood.
Journal of theoretical biology 2005;236(3):242-55.
2005: Johannes D Veldhuis; Daniel M Keenan; Kristi Mielke; John M Miles; Cyril Y Bowers
Testosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacy.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(4):577-86.
2005: Malene Hollingdal; Jeppe Sturis; M-A Gall; P Damsbo; S Pincus; Johannes D Veldhuis; Niels Pørksen; Ole Schmitz; Claus Juhl
Repaglinide treatment amplifies first-phase insulin secretion and high-frequency pulsatile insulin release in Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(10):1408-13.
2005: James N Roemmich; Pamela A Clark; Arthur Weltman; Johannes D Veldhuis; Alan D Rogol
Pubertal alterations in growth and body composition: IX. Altered spontaneous secretion and metabolic clearance of growth hormone in overweight youth.
Metabolism: clinical and experimental 2005;54(10):1374-83.
2005: Dorte Glintborg; René K Støving; Claus Hagen; Anne Pernille Hermann; Jan Frystyk; Johannes D Veldhuis; Allan Flyvbjerg; Marianne Andersen
Pioglitazone treatment increases spontaneous growth hormone (GH) secretion and stimulated GH levels in polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2005;90(10):5605-12.
2005: Peter Y Liu; Paul Y Takahashi; Pamela D Roebuck; Ali Iranmanesh; Johannes D Veldhuis
Aging in healthy men impairs recombinant human luteinizing hormone (LH)-stimulated testosterone secretion monitored under a two-day intravenous pulsatile LH clamp.
The Journal of clinical endocrinology and metabolism 2005;90(10):5544-50.
2005: Peter Y Liu; Paul Y Takahashi; Pamela D Roebuck; Ali Iranmanesh; Johannes D Veldhuis
Age-specific changes in the regulation of LH-dependent testosterone secretion: assessing responsiveness to varying endogenous gonadotropin output in normal men.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(3):R721-8.
2005: Cacia Soares-Welch; Kristi Mielke; Cyril Y Bowers; Johannes D Veldhuis
Short-term testosterone supplementation does not activate GH and IGF-I production in postmenopausal women.
Clinical endocrinology 2005;63(1):32-8.
2005: Ali Iranmanesh; Johannes D Veldhuis
Combined inhibition of types I and II 5 alpha-reductase selectively augments the basal (nonpulsatile) mode of testosterone secretion in young men.
The Journal of clinical endocrinology and metabolism 2005;90(7):4232-7.
2005: Johannes D Veldhuis; Ali Iranmanesh; Cyril Y Bowers
Joint mechanisms of impaired growth-hormone pulse renewal in aging men.
The Journal of clinical endocrinology and metabolism 2005;90(7):4177-83.
2005: Peter Y Liu; Steven M Pincus; Daniel M Keenan; Ferdinand Roelfsema; Johannes D Veldhuis
Joint synchrony of reciprocal hormonal signaling in human paradigms of both ACTH excess and cortisol depletion.
American journal of physiology. Endocrinology and metabolism 2005;289(1):E160-5.
2005: Juris J Meier; Johannes D Veldhuis; Peter C Butler
Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans.
Diabetes 2005;54(6):1649-56.
2005: Leon S Farhy; Johannes D Veldhuis
Deterministic construct of amplifying actions of ghrelin on pulsatile growth hormone secretion.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(6):R1649-63.
2005: Paul Y Takahashi; Peter Y Liu; Pamela D Roebuck; Ali Iranmanesh; Johannes D Veldhuis
Graded inhibition of pulsatile luteinizing hormone secretion by a selective gonadotropin-releasing hormone (GnRH)-receptor antagonist in healthy men: evidence that age attenuates hypothalamic GnRH outflow.
The Journal of clinical endocrinology and metabolism 2005;90(5):2768-74.
2005: Johannes D Veldhuis; Leon S Farhy; Arthur Weltman; Jonathan Kuipers; Judy Y Weltman; Laurie Wideman
Gender modulates sequential suppression and recovery of pulsatile growth hormone secretion by physiological feedback signals in young adults.
The Journal of clinical endocrinology and metabolism 2005;90(5):2874-81.
2005: Johannes D Veldhuis; Jan Frystyk; Ali Iranmanesh; Hans Ørskov
Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I/IGFBP-1 concentrations.
The Journal of clinical endocrinology and metabolism 2005;90(5):2941-7.
2005: Cacia Soares-Welch; Leon S Farhy; Kristi Mielke; Farid H Mahmud; John M Miles; Cyril Y Bowers; Johannes D Veldhuis
Complementary secretagogue pairs unmask prominent gender-related contrasts in mechanisms of growth hormone pulse renewal in young adults.
The Journal of clinical endocrinology and metabolism 2005;90(4):2225-32.
2005: Peter Y Liu; Kelley A Hoey; Kristi L Mielke; Johannes D Veldhuis; Sundeep Khosla
A randomized placebo-controlled trial of short-term graded transdermal estradiol in healthy gonadotropin-releasing hormone agonist-suppressed pre- and postmenopausal women: effects on serum markers of bone turnover, insulin-like growth factor-I, and osteoclastogenic mediators.
The Journal of clinical endocrinology and metabolism 2005;90(4):1953-60.
2005: Johannes D Veldhuis; Nathan J D Veldhuis; Daniel M Keenan; Ali Iranmanesh
Age diminishes the testicular steroidogenic response to repeated intravenous pulses of recombinant human LH during acute GnRH-receptor blockade in healthy men.
American journal of physiology. Endocrinology and metabolism 2005;288(4):E775-81.
2005: Dana Erickson; Daniel M Keenan; Leon S Farhy; Kristi Mielke; Cyril Y Bowers; Johannes D Veldhuis
Determinants of dual secretagogue drive of burst-like growth hormone secretion in premenopausal women studied under a selective estradiol clamp.
The Journal of clinical endocrinology and metabolism 2005;90(3):1741-51.
2005: Maarten O van Aken; Alberto M Pereira; Sjoerd W van Thiel; Gerrit van den Berg; Marijke Frölich; Johannes D Veldhuis; Johannes A Romijn; Ferdinand Roelfsema
Irregular and frequent cortisol secretory episodes with preserved diurnal rhythmicity in primary adrenal Cushing's syndrome.
The Journal of clinical endocrinology and metabolism 2005;90(3):1570-7.
2005: Johannes D Veldhuis; Stacey M Anderson; Ali Iranmanesh; Cyril Y Bowers
Testosterone blunts feedback inhibition of growth hormone secretion by experimentally elevated insulin-like growth factor-I concentrations.
The Journal of clinical endocrinology and metabolism 2005;90(3):1613-7.
2005: Johannes D Veldhuis; Anthony Bae; Ronald S Swerdloff; Ali Iranmanesh; Christina Wang
Experimentally induced androgen depletion accentuates ethnicity-related contrasts in luteinizing hormone secretion in asian and caucasian men.
The Journal of clinical endocrinology and metabolism 2005;90(3):1632-8.
2005: Stefania Bonadonna; Anna Burattin; Monica Nuzzo; Giovanna Bugari; Enrico Agabiti Rosei; Domenico Valle; Nicoletta Iori; John P Bilezikian; Johannes D Veldhuis; Andrea Giustina
Chronic glucocorticoid treatment alters spontaneous pulsatile parathyroid hormone secretory dynamics in human subjects.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(2):199-205.
2005: Johannes D Veldhuis; James N Roemmich; Erick J Richmond; Alan D Rogol; Jennifer C Lovejoy; Melinda Sheffield-Moore; Nelly Mauras; Cyril Y Bowers
Endocrine control of body composition in infancy, childhood, and puberty.
Endocrine reviews 2005;26(1):114-46.
2005: Peter Y Liu; Steven M Pincus; Daniel M Keenan; Ferdinand Roelfsema; Johannes D Veldhuis
Analysis of bidirectional pattern synchrony of concentration-secretion pairs: implementation in the human testicular and adrenal axes.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(2):R440-6.
2005: Johannes D Veldhuis; Daniel M Keenan; Ali Iranmanesh
Mechanisms of ensemble failure of the male gonadal axis in aging.
Journal of endocrinological investigation 2005;28(3 Suppl):8-13.
2005: Johannes D Veldhuis; Ali Iranmanesh; Thomas Mulligan
Age and testosterone feedback jointly control the dose-dependent actions of gonadotropin-releasing hormone in healthy men.
The Journal of clinical endocrinology and metabolism 2005;90(1):302-9.
2005: Johannes D Veldhuis; Ali Iranmanesh
Short-term aromatase-enzyme blockade unmasks impaired feedback adaptations in luteinizing hormone and testosterone secretion in older men.
The Journal of clinical endocrinology and metabolism 2005;90(1):211-8.
2005: Maarten O van Aken; Alberto M Pereira; Marijke Frölich; Johannes A Romijn; Hanno Pijl; Johannes D Veldhuis; Ferdinand Roelfsema
Growth hormone secretion in primary adrenal Cushing's syndrome is disorderly and inversely correlated with body mass index.
American journal of physiology. Endocrinology and metabolism 2005;288(1):E63-70.
2004: Johannes D Veldhuis; James T Patrie; Kirsten Frick; Judy Y Weltman; Arthur Weltman
Sustained growth hormone (GH) and insulin-like growth factor I responses to prolonged high-dose twice-daily GH-releasing hormone stimulation in middle-aged and older men.
The Journal of clinical endocrinology and metabolism 2004;89(12):6325-30.
2004: Johannes D Veldhuis; James T Patrie; Kimberly T Brill; Judy Y Weltman; Eugenio E Mueller; Cyril Y Bowers; Arthur Weltman
Contributions of gender and systemic estradiol and testosterone concentrations to maximal secretagogue drive of burst-like growth hormone secretion in healthy middle-aged and older adults.
The Journal of clinical endocrinology and metabolism 2004;89(12):6291-6.
2004: Richard C Seals; Randall J Urban; Natesampillai Sekar; Johannes D Veldhuis
Up-regulation of basal transcriptional activity of the cytochrome P450 cholesterol side-chain cleavage (CYP11A) gene by isoform-specific calcium-calmodulin-dependent protein kinase in primary cultures of ovarian granulosa cells.
Endocrinology 2004;145(12):5616-22.
2004: Johannes D Veldhuis; Ali Iranmanesh; Daniel M Keenan
Erosion of endogenous testosterone-driven negative feedback on pulsatile luteinizing hormone secretion in healthy aging men.
The Journal of clinical endocrinology and metabolism 2004;89(11):5753-61.
2004: Johannes D Veldhuis; Judy Y Weltman; Arthur Weltman; Ali Iranmanesh; Eugenio E Muller; Cyril Y Bowers
Age and secretagogue type jointly determine dynamic growth hormone responses to exogenous insulin-like growth factor-negative feedback in healthy men.
The Journal of clinical endocrinology and metabolism 2004;89(11):5542-8.
2004: Peter Y Liu; Ronald S Swerdloff; Johannes D Veldhuis
Clinical review 171: The rationale, efficacy and safety of androgen therapy in older men: future research and current practice recommendations.
The Journal of clinical endocrinology and metabolism 2004;89(10):4789-96.
2004: Joel A Posener; Johannes D Veldhuis; Michael A Province; Gordon H Williams; Alan F Schatzberg
Process irregularity of cortisol and adrenocorticotropin secretion in men with major depressive disorder.
Psychoneuroendocrinology 2004;29(9):1129-37.
2004: Daniel M Keenan; Ferdinand Roelfsema; Johannes D Veldhuis
Endogenous ACTH concentration-dependent drive of pulsatile cortisol secretion in the human.
American journal of physiology. Endocrinology and metabolism 2004;287(4):E652-61.
2004: Dana Erickson; Daniel M Keenan; Kristi Mielke; Kandace Bradford; Cyril Y Bowers; John M Miles; Johannes D Veldhuis
Dual secretagogue drive of burst-like growth hormone secretion in postmenopausal compared with premenopausal women studied under an experimental estradiol clamp.
The Journal of clinical endocrinology and metabolism 2004;89(9):4746-54.
2004: Ali Iranmanesh; Cyril Y Bowers; Johannes D Veldhuis
Activation of somatostatin-receptor subtype-2/-5 suppresses the mass, frequency, and irregularity of growth hormone (GH)-releasing peptide-2-stimulated GH secretion in men.
The Journal of clinical endocrinology and metabolism 2004;89(9):4581-7.
2004: Johannes D Veldhuis; Ali Iranmanesh
Pulsatile intravenous infusion of recombinant human luteinizing hormone under acute gonadotropin-releasing hormone receptor blockade reconstitutes testosterone secretion in young men.
The Journal of clinical endocrinology and metabolism 2004;89(9):4474-9.
2004: Brian Irving; James T Patrie; Stacey M Anderson; Deidre D Watson-Winfield; Kirsten I Frick; William S Evans; Johannes D Veldhuis; Arthur Weltman
The effects of time following acute growth hormone administration on metabolic and power output measures during acute exercise.
The Journal of clinical endocrinology and metabolism 2004;89(9):4298-305.
2004: Natesampillai Sekar; Johannes D Veldhuis
Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL receptor gene by insulin and LH in cultured porcine granulosa-luteal cells.
American journal of physiology. Endocrinology and metabolism 2004;287(1):E128-35.
2004: Maarten O van Aken; Alberto M Pereira; Gerrit van den Berg; Johannes A Romijn; Johannes D Veldhuis; Ferdinand Roelfsema
Profound amplification of secretory-burst mass and anomalous regularity of ACTH secretory process in patients with Nelson's syndrome compared with Cushing's disease.
Clinical endocrinology 2004;60(6):765-72.
2004: Gongqiao Zhang; Johannes D Veldhuis
Requirement for proximal putative Sp1 and AP-2 cis-deoxyribonucleic acid elements in mediating basal and luteinizing hormone- and insulin-dependent in vitro transcriptional activation of the CYP17 gene in porcine theca cells.
Endocrinology 2004;145(6):2760-6.
2004: Leon S Farhy; Johannes D Veldhuis
Putative GH pulse renewal: periventricular somatostatinergic control of an arcuate-nuclear somatostatin and GH-releasing hormone oscillator.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(6):R1030-42.
2004: Gongqiao Zhang; Johannes D Veldhuis
Insulin drives transcriptional activity of the CYP17 gene in primary cultures of swine theca cells.
Biology of reproduction 2004;70(6):1600-5.
2004: Christopher R McCartney; Amy B Bellows; Melissa B Gingrich; Yun Hu; William S Evans; John C Marshall; Johannes D Veldhuis
Exaggerated 17-hydroxyprogesterone response to intravenous infusions of recombinant human LH in women with polycystic ovary syndrome.
American journal of physiology. Endocrinology and metabolism 2004;286(6):E902-8.
2004: Cyril Y Bowers; Ramona Granda; Subburaman Mohan; Jonathan Kuipers; David J Baylink; Johannes D Veldhuis
Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women.
The Journal of clinical endocrinology and metabolism 2004;89(5):2290-300.
2004: Daniel M Keenan; Susan Alexander; C H G Irvine; Iain Clarke; Chris Scott; Anne Turner; Alan J Tilbrook; Benedict J Canny; Johannes D Veldhuis
Reconstruction of in vivo time-evolving neuroendocrine dose-response properties unveils admixed deterministic and stochastic elements.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6740-5.
2004: Eveline W C M Van Dam; Ferdinand Roelfsema; Johannes D Veldhuis; Simone Hogendoorn; Jos J M Westenberg; Frans M Helmerhorst; Marijke Frölich; H Michiel J Krans; A Edo Meinders; Hanno Pijl
Retention of estradiol negative feedback relationship to LH predicts ovulation in response to caloric restriction and weight loss in obese patients with polycystic ovary syndrome.
American journal of physiology. Endocrinology and metabolism 2004;286(4):E615-20.
2004: Julio Licinio; Sinan Caglayan; metin ozata; Bulent O Yildiz; Patricia B de Miranda; Fiona O'Kirwan; Robert Whitby; Liyin Liang; Pinchas Cohen; Shalender Bhasin; Ronald M Krauss; Johannes D Veldhuis; Anthony J Wagner; Alex M DePaoli; Samuel M McCann; Ma-Li Wong
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4531-6.
2004: Johannes D Veldhuis; Stacey M Anderson; Petra Kok; Ali Iranmanesh; Jan Frystyk; Hans Ørskov; Daniel M Keenan
Estradiol supplementation modulates growth hormone (GH) secretory-burst waveform and recombinant human insulin-like growth factor-I-enforced suppression of endogenously driven GH release in postmenopausal women.
The Journal of clinical endocrinology and metabolism 2004;89(3):1312-8.
2004: Johannes D Veldhuis; William S Evans; Ali Iranmanesh; Arthur Weltman; Cyril Y Bowers
Short-term testosterone supplementation relieves growth hormone autonegative feedback in men.
The Journal of clinical endocrinology and metabolism 2004;89(3):1285-90.
2004: Johannes D Veldhuis; James T Patrie; Laurie Wideman; Mark Patterson; Judy Y Weltman; Arthur Weltman
Contrasting negative-feedback control of endogenously driven and exercise-stimulated pulsatile growth hormone secretion in women and men.
The Journal of clinical endocrinology and metabolism 2004;89(2):840-6.
2004: Robert A Ritzel; John B Hansen; Johannes D Veldhuis; Peter C Butler
Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.
The Journal of clinical endocrinology and metabolism 2004;89(2):795-805.
2004: Daniel M Keenan; Johannes D Veldhuis
Divergent gonadotropin-gonadal dose-responsive coupling in healthy young and aging men.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(2):R381-9.
2004: Michael L Johnson; Amelia Virostko; Johannes D Veldhuis; William S Evans
Deconvolution analysis as a hormone pulse-detection algorithm.
Methods in enzymology 2004;384():40-54.
2004: Torben Østergård; Kristine B Degn; Mari-Anne Gall; Richard D Carr; Johannes D Veldhuis; Mads K Thomsen; Robert A Rizza; Ole Schmitz
The insulin secretagogues glibenclamide and repaglinide do not influence growth hormone secretion in humans but stimulate glucagon secretion during profound insulin deficiency.
The Journal of clinical endocrinology and metabolism 2004;89(1):297-302.
2004: Johannes D Veldhuis; Stacey M Anderson; James T Patrie; Cyril Y Bowers
Estradiol supplementation in postmenopausal women doubles rebound-like release of growth hormone (GH) triggered by sequential infusion and withdrawal of somatostatin: evidence that estrogen facilitates endogenous GH-releasing hormone drive.
The Journal of clinical endocrinology and metabolism 2004;89(1):121-7.
2004: Frank Weekers; Marina Michalaki; Willy Coopmans; Erik Van Herck; Johannes D Veldhuis; Veerle M Darras; Greet Van den Berghe
Endocrine and metabolic effects of growth hormone (GH) compared with GH-releasing peptide, thyrotropin-releasing hormone, and insulin infusion in a rabbit model of prolonged critical illness.
Endocrinology 2004;145(1):205-13.
2004: Nienke R Biermasz; Alberto M Pereira; Marijke Frölich; Johannes A Romijn; Johannes D Veldhuis; Ferdinand Roelfsema
Octreotide represses secretory-burst mass and nonpulsatile secretion but does not restore event frequency or orderly GH secretion in acromegaly.
American journal of physiology. Endocrinology and metabolism 2004;286(1):E25-30.
2003: Claus Peter Schmitt; Jennifer Obry; Reinhard Feneberg; Johannes D Veldhuis; Otto Mehls; Eberhard Ritz; Franz Schaefer
Beta1-adrenergic blockade augments pulsatile PTH secretion in humans.
Journal of the American Society of Nephrology : JASN 2003;14(12):3245-50.
2003: Johannes D Veldhuis; William S Evans; Cyril Y Bowers
Estradiol supplementation enhances submaximal feed-forward drive of growth hormone (GH) secretion by recombinant human GH-releasing hormone-1,44-amide in a putatively somatostatin-withdrawn milieu.
The Journal of clinical endocrinology and metabolism 2003;88(11):5484-9.
2003: Daniel M Keenan; William S Evans; Johannes D Veldhuis
Control of LH secretory-burst frequency and interpulse-interval regularity in women.
American journal of physiology. Endocrinology and metabolism 2003;285(5):E938-48.
2003: Leon S Farhy; Johannes D Veldhuis
Joint pituitary-hypothalamic and intrahypothalamic autofeedback construct of pulsatile growth hormone secretion.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;285(5):R1240-9.
2003: Daniel M Keenan; Johannes D Veldhuis
Cortisol feedback state governs adrenocorticotropin secretory-burst shape, frequency, and mass in a dual-waveform construct: time of day-dependent regulation.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;285(5):R950-61.
2003: Johannes D Veldhuis; Cyril Y Bowers
Sex-steroid modulation of growth hormone (GH) secretory control: three-peptide ensemble regulation under dual feedback restraint by GH and IGF-I.
Endocrine 2003;22(1):25-40.
2003: Laura Gianotti; Johannes D Veldhuis; Silvia Destefanis; Fabio Lanfranco; Josefina Ramunni; Emanuela Arvat; M Marzetto; François Boutignon; Romano Deghenghi; Ezio Ghigo
Suppression and recovery of LH secretion by a potent and selective GnRH-receptor antagonist peptide in healthy early follicular-phase women are mediated via selective control of LH secretory burst mass.
Clinical endocrinology 2003;59(4):526-32.
2003: Arthur Weltman; Laurie Wideman; Judy Y Weltman; Johannes D Veldhuis
Neuroendocrine control of GH release during acute aerobic exercise.
Journal of endocrinological investigation 2003;26(9):843-50.
2003: Johannes D Veldhuis; Cyril Y Bowers
Human GH pulsatility: an ensemble property regulated by age and gender.
Journal of endocrinological investigation 2003;26(9):799-813.
2003: Daniel M Keenan; Ferdinand Roelfsema; Nienke Biermasz; Johannes D Veldhuis
Physiological control of pituitary hormone secretory-burst mass, frequency, and waveform: a statistical formulation and analysis.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;285(3):R664-73.
2003: Soon H Song; Christopher J Rhodes; Johannes D Veldhuis; Peter C Butler
Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets.
Endocrinology 2003;144(8):3399-405.
2003: Reinhard Feneberg; Franz Schaefer; Johannes D Veldhuis
Neuroendocrine adaptations in renal disease.
Pediatric nephrology (Berlin, Germany) 2003;18(6):492-7.
2003: Johannes D Veldhuis
Neuroendocrine facets of human puberty.
Neurobiology of aging 2003;24 Suppl 1():S93-S119; discussion S121-2.
2003: Johannes D Veldhuis; Cyril Y Bowers
Three-peptide control of pulsatile and entropic feedback-sensitive modes of growth hormone secretion: modulation by estrogen and aromatizable androgen.
Journal of pediatric endocrinology & metabolism : JPEM 2003;16 Suppl 3():587-605.
2003: Jean L Chan; Kathleen Heist; Alex M DePaoli; Johannes D Veldhuis; Christos S Mantzoros
The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men.
The Journal of clinical investigation 2003;111(9):1409-21.
2003: Alan D Rogol; Sandra L Blethen; Judy P Sy; Johannes D Veldhuis
Do growth hormone (GH) serial sampling, insulin-like growth factor-I (IGF-I) or auxological measurements have an advantage over GH stimulation testing in predicting the linear growth response to GH therapy?
Clinical endocrinology 2003;58(2):229-37.
2003: Robert A Ritzel; Johannes D Veldhuis; Peter C Butler
Glucose stimulates pulsatile insulin secretion from human pancreatic islets by increasing secretory burst mass: dose-response relationships.
The Journal of clinical endocrinology and metabolism 2003;88(2):742-7.
2003: Claus Peter Schmitt; Swee Löcken; Otto Mehls; Johannes D Veldhuis; Thomas Lehnert; Eberhard Ritz; Franz Schaefer
PTH pulsatility but not calcium sensitivity is restored after total parathyroidectomy with heterotopic autotransplantation.
Journal of the American Society of Nephrology : JASN 2003;14(2):407-14.
2003: Johannes D Veldhuis; Steven M Pincus; Daniel M Keenan
Noninvasive in vivo investigative probes of adaptive mechanisms of neuroendocrine regulation: the paradigm of the hypothalamo-pituitary-gonadal axis in the aging male.
Journal of endocrinological investigation 2003;26(7 Suppl):2-14.
2003: Johannes D Veldhuis
A tripeptidyl ensemble perspective of interactive control of growth hormone secretion.
Hormone research 2003;60(Suppl 1):86-101.
2002: Johannes D Veldhuis; Martin Bidlingmaier; Stacey M Anderson; William S Evans; Z Wu; Christian J Strasburger
Impact of experimental blockade of peripheral growth hormone (GH) receptors on the kinetics of endogenous and exogenous GH removal in healthy women and men.
The Journal of clinical endocrinology and metabolism 2002;87(12):5737-45.
2002: Kimberly T Brill; Arthur Weltman; Angela Gentili; James T Patrie; David A Fryburg; John B Hanks; Randall J Urban; Johannes D Veldhuis
Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men.
The Journal of clinical endocrinology and metabolism 2002;87(12):5649-57.
2002: Juan Carlos López-Alvarenga; Teresa Zariñán; Aleida Olivares; Jorge González-Barranco; Johannes D Veldhuis; Alfredo Ulloa-Aguirre
Poorly controlled type I diabetes mellitus in young men selectively suppresses luteinizing hormone secretory burst mass.
The Journal of clinical endocrinology and metabolism 2002;87(12):5507-15.
2002: Roberto Salvatori; Xiaoguang Fan; Johannes D Veldhuis; Robert Couch
Serum GH response to pharmacological stimuli and physical exercise in two siblings with two new inactivating mutations in the GH-releasing hormone receptor gene.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(5):591-6.
2002: Laura C Rall; Joseph Walsmith; Laura Snydman; Seymour Reichlin; Johannes D Veldhuis; Joseph J Kehayias; Leslie W Abad; Nancy T Lundgren; Ronenn Roubenoff
Cachexia in rheumatoid arthritis is not explained by decreased growth hormone secretion.
Arthritis and rheumatism 2002;46(10):2574-7.
2002: Richard C Earnhardt; Johannes D Veldhuis; Greg Cornett; John B Hanks
Pathophysiology of hyperinsulinemia following pancreas transplantation: altered pulsatile versus Basal insulin secretion and the role of specific transplant anatomy in dogs.
Annals of surgery 2002;236(4):480-90; discussion 490-1.
2002: Kin-Chuen Leung; Chris Howe; Lily Y-Y Gui; Graham J Trout; Johannes D Veldhuis; Ken K Y Ho
Physiological and pharmacological regulation of 20-kDa growth hormone.
American journal of physiology. Endocrinology and metabolism 2002;283(4):E836-43.
2002: Eveline W C M Van Dam; Ferdinand Roelfsema; Frans H Helmerhorst; Marijke Frölich; A Edo Meinders; Johannes D Veldhuis; Hanno Pijl
Low amplitude and disorderly spontaneous growth hormone release in obese women with or without polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2002;87(9):4225-30.
2002: Richard J Krieg; Winnie Chan; Kwei-Chi Lin; Nancy B Kuemmerle; Johannes D Veldhuis; James C M Chan
Growth hormone and growth hormone-related mRNA in uremic rats: effect of a growth hormone secretagogue.
Pediatric nephrology (Berlin, Germany) 2002;17(8):585-90.
2002: Erick J Richmond; Alan D Rogol; D Basdemir; Olivia L Veldhuis; William Clarke; Cyril Y Bowers; Johannes D Veldhuis
Accelerated escape from GH autonegative feedback in midpuberty in males: evidence for time-delimited GH-induced somatostatinergic outflow in adolescent boys.
The Journal of clinical endocrinology and metabolism 2002;87(8):3837-44.
2002: Maria C Garcia-Rudaz; María Gabriela Ropelato; María Eugenia Escobar; Johannes D Veldhuis; Marta Barontini
Amplified and orderly growth hormone secretion characterizes lean adolescents with polycystic ovary syndrome.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(2):207-16.
2002: I Ross Young; Eng-Cheng Chan; Roger Smith; George Chrousos; Johannes D Veldhuis; Benedict J Canny
Effect of antalarmin, a novel corticotropin-releasing hormone antagonist, on the dynamic function of the preterm ovine fetal hypothalamo-pituitary-adrenal axis.
Neuroendocrinology 2002;76(1):47-54.
2002: Anargyros N Moulas; Richard J Krieg; Johannes D Veldhuis; James C M Chan
Effect of the GH secretagogue L-163,255 and restricted feeding time on GH pulsatility in the rat.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(1):143-8.
2002: Johan Svensson; Johannes D Veldhuis; Ali Iranmanesh; Bengt-Ake Bengtsson; Gudmundur Johannsson
Increased orderliness of growth hormone (GH) secretion in GH-deficient adults with low serum insulin-like growth factor I.
The Journal of clinical endocrinology and metabolism 2002;87(6):2863-9.
2002: Mark Quigg; James M Kiely; Bassel F Shneker; Johannes D Veldhuis; Edward H Bertram
Interictal and postictal alterations of pulsatile secretions of luteinizing hormone in temporal lobe epilepsy in men.
Annals of neurology 2002;51(5):559-66.
2002: Greet Van den Berghe; Robert C Baxter; Frank Weekers; Patrick F Wouters; Cyril Y Bowers; Ali Iranmanesh; Johannes D Veldhuis; Roger Bouillon
The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone.
Clinical endocrinology 2002;56(5):655-69.
2002: Reinhard Feneberg; Monika Sparber; Johannes D Veldhuis; Otto Mehls; Eberhard Ritz; Franz Schaefer
Altered temporal organization of plasma insulin oscillations in chronic renal failure.
The Journal of clinical endocrinology and metabolism 2002;87(5):1965-73.
2002: Cathy J Pritzlaff-Roy; Laurie Widemen; Judy Y Weltman; Rob Abbott; Margaret Gutgesell; Mark L Hartman; Johannes D Veldhuis; Arthur Weltman
Gender governs the relationship between exercise intensity and growth hormone release in young adults.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(5):2053-60.
2002: Eveline W C M Van Dam; Ferdinand Roelfsema; Johannes D Veldhuis; Frans M Helmerhorst; Marijke Frölich; A Edo Meinders; H Michiel J Krans; Hanno Pijl
Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS.
American journal of physiology. Endocrinology and metabolism 2002;282(4):E865-72.
2002: Johannes D Veldhuis; George Zhang; James C Garmey
Troglitazone, an insulin-sensitizing thiazolidinedione, represses combined stimulation by LH and insulin of de novo androgen biosynthesis by thecal cells in vitro.
The Journal of clinical endocrinology and metabolism 2002;87(3):1129-33.
2002: Mauro Maccario; Johannes D Veldhuis; Fabio Broglio; Lidia Di Vito; Emanuela Arvat; Romano Deghenghi; Ezio Ghigo
Impact of two or three daily subcutaneous injections of hexarelin, a synthetic growth hormone (GH) secretagogue, on 24-h GH, prolactin, adrenocorticotropin and cortisol secretion in humans.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(3):310-8.
2002: Frank Weekers; Erik Van Herck; Willy Coopmans; Marina Michalaki; Cyril Y Bowers; Johannes D Veldhuis; Greet Van den Berghe
A novel in vivo rabbit model of hypercatabolic critical illness reveals a biphasic neuroendocrine stress response.
Endocrinology 2002;143(3):764-74.
2002: Leon S Farhy; Martin Straume; Michael L Johnson; Boris Kovatchev; Johannes D Veldhuis
Unequal autonegative feedback by GH models the sexual dimorphism in GH secretory dynamics.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(3):R753-64.
2002: Niels Pørksen; Thorbjørn Grøfte; Jacob Greisen; Anette Mengel; Claus Juhl; Johannes D Veldhuis; Ole Schmitz; Martin Rössle; Hendrik Vilstrup
Human insulin release processes measured by intraportal sampling.
American journal of physiology. Endocrinology and metabolism 2002;282(3):E695-702.
2002: Johannes D Veldhuis; Terry P Fletcher; Kathryn L Gatford; Adrian R Egan; Iain J Clarke
Hypophyseal-portal somatostatin (SRIH) and jugular venous growth hormone secretion in the conscious unrestrained ewe.
Neuroendocrinology 2002;75(2):83-91.
2002: Johannes D Veldhuis; William S Evans; Cyril Y Bowers
Impact of estradiol supplementation on dual peptidyl drive of GH secretion in postmenopausal women.
The Journal of clinical endocrinology and metabolism 2002;87(2):859-66.
2002: Angela Gentili; Thomas Mulligan; Michael F Godschalk; John N Clore; James T Patrie; Ali Iranmanesh; Johannes D Veldhuis
Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men.
The Journal of clinical endocrinology and metabolism 2002;87(2):825-34.
2002: Claus Juhl; Thorbjørn Grøfte; Peter C Butler; Johannes D Veldhuis; Ole Schmitz; Niels Pørksen
Effects of fasting on physiologically pulsatile insulin release in healthy humans.
Diabetes 2002;51 Suppl 1():S255-7.
2002: Niels Pørksen; Malene Hollingdal; Claus Juhl; Peter Butler; Johannes D Veldhuis; Ole Schmitz
Pulsatile insulin secretion: detection, regulation, and role in diabetes.
Diabetes 2002;51 Suppl 1():S245-54.
2002: Joaquin Lado-Abeal; Johannes D Veldhuis; Reid L Norman
Glucose relays information regarding nutritional status to the neural circuits that control the somatotropic, corticotropic, and gonadotropic axes in adult male rhesus macaques.
Endocrinology 2002;143(2):403-10.
2002: Laurie Wideman; Judy Y Weltman; Mark L Hartman; Johannes D Veldhuis; Arthur Weltman
Growth hormone release during acute and chronic aerobic and resistance exercise: recent findings.
Sports medicine (Auckland, N.Z.) 2002;32(15):987-1004.
2002: Johannes D Veldhuis; Ali Iranmanesh; Thomas Mulligan; Cyril Y Bowers
Mechanisms of conjoint failure of the somatotropic and gonadal axes in ageing men.
Novartis Foundation symposium 2002;242():98-118; discussion 118-24.
2002: Ferdinand Roelfsema; Nienke R Biermasz; Johannes D Veldhuis
Pulsatile, nyctohemeral and entropic characteristics of GH secretion in adult GH-deficient patients: selectively decreased pulsatile release and increased secretory disorderliness with preservation of diurnal timing and gender distinctions.
Clinical endocrinology 2002;56(1):79-87.
2002: Malene Hollingdal; Claus Juhl; R Dall; Jeppe Sturis; Johannes D Veldhuis; Ole Schmitz; Niels Pørksen
Glucocorticoid induced insulin resistance impairs basal but not glucose entrained high-frequency insulin pulsatility in humans.
Diabetologia 2002;45(1):49-55.
2002: Soon H Song; Lise L Kjems; Robert A Ritzel; Susan M McIntyre; Michael L Johnson; Johannes D Veldhuis; Peter C Butler
Pulsatile insulin secretion by human pancreatic islets.
The Journal of clinical endocrinology and metabolism 2002;87(1):213-21.
2002: Pamela D Schoppee; James C Garmey; Johannes D Veldhuis
Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells.
Biology of reproduction 2002;66(1):190-8.
2001: Stacey M Anderson; Laurie Wideman; James T Patrie; Arthur Weltman; Cyril Y Bowers; Johannes D Veldhuis
E2 supplementation selectively relieves GH's autonegative feedback on GH-releasing peptide-2-stimulated GH secretion.
The Journal of clinical endocrinology and metabolism 2001;86(12):5904-11.
2001: Johannes D Veldhuis; Michael L Johnson; Olivia L Veldhuis; Martin Straume; Steven M Pincus
Impact of pulsatility on the ensemble orderliness (approximate entropy) of neurohormone secretion.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(6):R1975-85.
2001: Daniel M Keenan; Johannes D Veldhuis
Disruption of the hypothalamic luteinizing hormone pulsing mechanism in aging men.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(6):R1917-24.
2001: Marta Barontini; MC García-Rudaz; Johannes D Veldhuis
Mechanisms of hypothalamic-pituitary-gonadal disruption in polycystic ovarian syndrome.
Archives of medical research 2001;32(6):544-52.
2001: Johannes D Veldhuis; Ali Iranmanesh; D Naftolowitz; N Tatham; Frederick Cassidy; B J Carroll
Corticotropin secretory dynamics in humans under low glucocorticoid feedback.
The Journal of clinical endocrinology and metabolism 2001;86(11):5554-63.
2001: Hanno Pijl; Janneke G Langendonk; Jacobus Burggraaf; Marijke Frölich; Adam Cohen; Johannes D Veldhuis; A Edo Meinders
Altered neuroregulation of GH secretion in viscerally obese premenopausal women.
The Journal of clinical endocrinology and metabolism 2001;86(11):5509-15.
2001: Arthur Weltman; Judy Y Weltman; Johannes D Veldhuis; Mark L Hartman
Body composition, physical exercise, growth hormone and obesity.
Eating and weight disorders : EWD 2001;6(3 Suppl):28-37.
2001: Lise L Kjems; Barbara M Kirby; Elizabeth Welsh; Johannes D Veldhuis; M Straume; S S McIntyre; D Yang; P Lefèbvre; Peter C Butler
Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig.
Diabetes 2001;50(9):2001-12.
2001: Johannes D Veldhuis; Steven M Pincus; Maria C Garcia-Rudaz; María Gabriela Ropelato; María Eugenia Escobar; Marta Barontini
Disruption of the synchronous secretion of leptin, LH, and ovarian androgens in nonobese adolescents with the polycystic ovarian syndrome.
The Journal of clinical endocrinology and metabolism 2001;86(8):3772-8.
2001: Claus Juhl; Niels Pørksen; SM Pincus; A P Hansen ; Johannes D Veldhuis; Ole Schmitz
Acute and short-term administration of a sulfonylurea (gliclazide) increases pulsatile insulin secretion in type 2 diabetes.
Diabetes 2001;50(8):1778-84.
2001: Johannes D Veldhuis; Martin Bidlingmaier; Stacey M Anderson; Z Wu; Christian J Strasburger
Lowering total plasma insulin-like growth factor I concentrations by way of a novel, potent, and selective growth hormone (GH) receptor antagonist, pegvisomant (B2036-peg), augments the amplitude of GH secretory bursts and elevates basal/nonpulsatile GH release in healthy women and men.
The Journal of clinical endocrinology and metabolism 2001;86(7):3304-10.
2001: C S Mantzoros; metin ozata; Andre B Negrao; M A Suchard; M Ziotopoulou; Sinan Caglayan; R M Elashoff; R J Cogswell; Paulo J Negro; V Liberty; Ma-Li Wong; Johannes D Veldhuis; I Caglayan Ozdemir; Philip W Gold; J S Flier; Julio Licinio
Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans.
The Journal of clinical endocrinology and metabolism 2001;86(7):3284-91.
2001: Greet Van den Berghe; Frank Weekers; Robert C Baxter; Patrick F Wouters; Ali Iranmanesh; Roger Bouillon; Johannes D Veldhuis
Five-day pulsatile gonadotropin-releasing hormone administration unveils combined hypothalamic-pituitary-gonadal defects underlying profound hypoandrogenism in men with prolonged critical illness.
The Journal of clinical endocrinology and metabolism 2001;86(7):3217-26.
2001: MJ Bray; T M Vick; N Shah; Stacey M Anderson; Laurel W Rice; Ali Iranmanesh; William S Evans; Johannes D Veldhuis
Short-term estradiol replacement in postmenopausal women selectively mutes somatostatin's dose-dependent inhibition of fasting growth hormone secretion.
The Journal of clinical endocrinology and metabolism 2001;86(7):3143-9.
2001: Natesampillai Sekar; Johannes D Veldhuis
Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways.
Endocrinology 2001;142(7):2921-8.
2001: Leon S Farhy; Martin Straume; Michael L Johnson; Boris Kovatchev; Johannes D Veldhuis
A construct of interactive feedback control of the GH axis in the male.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(1):R38-51.
2001: Johannes D Veldhuis; S M Anderson; N Shah; M Bray; T Vick; Angela Gentili; Thomas Mulligan; Michael L Johnson; Arthur Weltman; William S Evans; Ali Iranmanesh
Neurophysiological regulation and target-tissue impact of the pulsatile mode of growth hormone secretion in the human.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2001;11 Suppl A():S25-37.
2001: John A. Schnorr; MJ Bray; Johannes D Veldhuis
Aromatization mediates testosterone's short-term feedback restraint of 24-hour endogenously driven and acute exogenous gonadotropin-releasing hormone-stimulated luteinizing hormone and follicle-stimulating hormone secretion in young men.
The Journal of clinical endocrinology and metabolism 2001;86(6):2600-6.
2001: Ferdinand Roelfsema; Nienke R Biermasz; RG Veldman; Johannes D Veldhuis; Marijke Frölich; Wilhelmina H Stokvis-Brantsma; Jan M Wit
Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses.
The Journal of clinical endocrinology and metabolism 2001;86(6):2459-64.
2001: M Bergendah; Johannes D Veldhuis
Is there a physiological role for gonadotrophin oligosaccharide heterogeneity in humans? III. Luteinizing hormone heterogeneity: a medical physiologist's perspective.
Human reproduction (Oxford, England) 2001;16(6):1058-64.
2001: Daniel M Keenan; Johannes D Veldhuis
Hypothesis testing of the aging male gonadal axis via a biomathematical construct.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(6):R1755-71.
2001: RG Veldman; Marijke Frölich; SM Pincus; Johannes D Veldhuis; Ferdinand Roelfsema
Basal, pulsatile, entropic, and 24-hour rhythmic features of secondary hyperprolactinemia due to functional pituitary stalk disconnection mimic tumoral (primary) hyperprolactinemia.
The Journal of clinical endocrinology and metabolism 2001;86(4):1562-7.
2001: J A Gusenoff; S Mitchell Harman; Johannes D Veldhuis; Jocelyn Jayme; Carol St Clair; Thomas Münzer; Colleen Christmas; Kieran G O'Connor; Thomas E Stevens; Michele F Bellantoni; Katharine M Pabst; Marc R Blackman
Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men.
American journal of physiology. Endocrinology and metabolism 2001;280(4):E616-25.
2001: Daniel M Keenan; Julio Licinio; Johannes D Veldhuis
A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4028-33.
2001: Debra L Waters; Clifford R Qualls; Richard I Dorin; Johannes D Veldhuis; Richard Baumgartner
Increased pulsatility, process irregularity, and nocturnal trough concentrations of growth hormone in amenorrheic compared to eumenorrheic athletes.
The Journal of clinical endocrinology and metabolism 2001;86(3):1013-9.
2001: Johannes D Veldhuis; Martin Straume; Ali Iranmanesh; Thomas Mulligan; Craig A Jaffe; Ariel L Barkan; Michael L Johnson; S Pincus
Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(3):R721-9.
2001: Johannes D Veldhuis; William S Evans; Cyril Y Bowers; S Anderson
Interactive regulation of postmenopausal growth hormone insulin-like growth factor axis by estrogen and growth hormone-releasing peptide-2.
Endocrine 2001;14(1):45-62.
2001: William S Evans; Stacey M Anderson; L T Hull; P P Azimi; Cyril Y Bowers; Johannes D Veldhuis
Continuous 24-hour intravenous infusion of recombinant human growth hormone (GH)-releasing hormone-(1-44)-amide augments pulsatile, entropic, and daily rhythmic GH secretion in postmenopausal women equally in the estrogen-withdrawn and estrogen-supplemented states.
The Journal of clinical endocrinology and metabolism 2001;86(2):700-12.
2001: Stacey M Anderson; N Shah; William S Evans; James T Patrie; Cyril Y Bowers; Johannes D Veldhuis
Short-term estradiol supplementation augments growth hormone (GH) secretory responsiveness to dose-varying GH-releasing peptide infusions in healthy postmenopausal women.
The Journal of clinical endocrinology and metabolism 2001;86(2):551-60.
2001: Johannes D Veldhuis; AD Zwart; Thomas Mulligan; Ali Iranmanesh
Muting of androgen negative feedback unveils impoverished gonadotropin-releasing hormone/luteinizing hormone secretory reactivity in healthy older men.
The Journal of clinical endocrinology and metabolism 2001;86(2):529-35.
2001: Johannes D Veldhuis; Steven M Pincus; R Mitamura; K Yano; N Suzuki; Y Ito; Yoshio Makita; A Okuno
Developmentally delimited emergence of more orderly luteinizing hormone and testosterone secretion during late prepuberty in boys.
The Journal of clinical endocrinology and metabolism 2001;86(1):80-9.
2001: Johannes D Veldhuis; Steven M Pincus; Maria C Garcia-Rudaz; María Gabriela Ropelato; María Eugenia Escobar; Marta Barontini
Disruption of the joint synchrony of luteinizing hormone, testosterone, and androstenedione secretion in adolescents with polycystic ovarian syndrome.
The Journal of clinical endocrinology and metabolism 2001;86(1):72-9.
2001: RG Veldman; Marijke Frölich; SM Pincus; Johannes D Veldhuis; Ferdinand Roelfsema
Hyperleptinemia in women with Cushing's disease is driven by high-amplitude pulsatile, but orderly and eurhythmic, leptin secretion.
European journal of endocrinology / European Federation of Endocrine Societies 2001;144(1):21-7.
2001: Ole Schmitz; Claus Juhl; Malene Hollingdal; Johannes D Veldhuis; Niels Pørksen; SM Pincus
Irregular circulating insulin concentrations in type 2 diabetes mellitus: an inverse relationship between circulating free fatty acid and the disorderliness of an insulin time series in diabetic and healthy individuals.
Metabolism: clinical and experimental 2001;50(1):41-6.
2001: Janneke G Langendonk; Johannes D Veldhuis; Jacobus Burggraaf; Rik C Schoemaker; Adam Cohen; A Edo Meinders; Hanno Pijl
Estimation of growth hormone secretion rate: impact of kinetic assumptions intrinsic to the analytical approach.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(1):R225-32.
2000: James C Garmey; HD Guthrie; Wesley M Garrett; M H Stoler; Johannes D Veldhuis
Localization and expression of low-density lipoprotein receptor, steroidogenic acute regulatory protein, cytochrome P450 side-chain cleavage and P450 17-alpha-hydroxylase/C17-20 lyase in developing swine follicles: in situ molecular hybridization and immunocytochemical studies.
Molecular and cellular endocrinology 2000;170(1-2):57-65.
2000: Cecilia Castro-Fernández; Aleida Olivares; Daniela Söderlund; Juan Carlos López-Alvarenga; Elena Zambrano; Johannes D Veldhuis; Alfredo Ulloa-Aguirre; Juan Pablo Méndez
A preponderance of circulating basic isoforms is associated with decreased plasma half-life and biological to immunological ratio of gonadotropin-releasing hormone-releasable luteinizing hormone in obese men.
The Journal of clinical endocrinology and metabolism 2000;85(12):4603-10.
2000: S H Song; S S McIntyre; H Shah; Johannes D Veldhuis; Peter C Hayes; Peter C Butler
Direct measurement of pulsatile insulin secretion from the portal vein in human subjects.
The Journal of clinical endocrinology and metabolism 2000;85(12):4491-9.
2000: Johannes D Veldhuis
Recent neuroendocrine facets of male reproductive aging.
Experimental gerontology 2000;35(9-10):1281-308.
2000: RG Veldman; Marijke Frölich; SM Pincus; Johannes D Veldhuis; Ferdinand Roelfsema
Apparently complete restoration of normal daily adrenocorticotropin, cortisol, growth hormone, and prolactin secretory dynamics in adults with Cushing's disease after clinically successful transsphenoidal adenomectomy.
The Journal of clinical endocrinology and metabolism 2000;85(11):4039-46.
2000: Matti Bergendahl; Ali Iranmanesh; C Pastor; William S Evans; Johannes D Veldhuis
Homeostatic joint amplification of pulsatile and 24-hour rhythmic cortisol secretion by fasting stress in midluteal phase women: concurrent disruption of cortisol-growth hormone, cortisol-luteinizing hormone, and cortisol-leptin synchrony.
The Journal of clinical endocrinology and metabolism 2000;85(11):4028-35.
2000: Natesampillai Sekar; Holly A LaVoie; Johannes D Veldhuis
Concerted regulation of steroidogenic acute regulatory gene expression by luteinizing hormone and insulin (or insulin-like growth factor I) in primary cultures of porcine granulosa-luteal cells.
Endocrinology 2000;141(11):3983-92.
2000: Laurie Wideman; Judy Y Weltman; James T Patrie; Cyril Y Bowers; N Shah; S Story; Johannes D Veldhuis; Arthur Weltman
Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(4):R1467-77.
2000: Laurie Wideman; Judy Y Weltman; James T Patrie; Cyril Y Bowers; N Shah; S Story; Arthur Weltman; Johannes D Veldhuis
Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 on GH release: influence of gender.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(4):R1455-66.
2000: Arthur Weltman; CJ Pritzlaff; Laurie Wideman; R V Considine; David A Fryburg; Margaret Gutgesell; Mark L Hartman; Johannes D Veldhuis
Intensity of acute exercise does not affect serum leptin concentrations in young men.
Medicine and science in sports and exercise 2000;32(9):1556-61.
2000: CJ Pritzlaff; Laurie Wideman; J Blumer; M Jensen; RD Abbott; Glenn A Gaesser; Johannes D Veldhuis; Arthur Weltman
Catecholamine release, growth hormone secretion, and energy expenditure during exercise vs. recovery in men.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;89(3):937-46.
2000: T Laedtke; Lise L Kjems; Niels Pørksen; O Schmitz; Johannes D Veldhuis; P C Kao; Peter C Butler
Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2000;279(3):E520-8.
2000: N Shah; William S Evans; Cyril Y Bowers; Johannes D Veldhuis
Oral estradiol administration modulates continuous intravenous growth hormone (GH)-releasing peptide-2-driven GH secretion in postmenopausal women.
The Journal of clinical endocrinology and metabolism 2000;85(8):2649-59.
2000: Arthur Weltman; CJ Pritzlaff; Laurie Wideman; Judy Y Weltman; J L Blumer; RD Abbott; Mark L Hartman; Johannes D Veldhuis
Exercise-dependent growth hormone release is linked to markers of heightened central adrenergic outflow.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;89(2):629-35.
2000: Malene Hollingdal; Claus Juhl; SM Pincus; Jeppe Sturis; Johannes D Veldhuis; Kenneth S Polonsky; Niels Pørksen; Ole Schmitz
Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes.
Diabetes 2000;49(8):1334-40.
2000: George Zhang; James C Garmey; Johannes D Veldhuis
Interactive stimulation by luteinizing hormone and insulin of the steroidogenic acute regulatory (StAR) protein and 17alpha-hydroxylase/17,20-lyase (CYP17) genes in porcine theca cells.
Endocrinology 2000;141(8):2735-42.
2000: Richard J Krieg; K Tokieda; James C M Chan; Johannes D Veldhuis
Impact of uremia on female reproductive cyclicity, ovulation, and luteinizing hormone in the rat.
Kidney international 2000;58(2):569-74.
2000: Steven M Pincus; Johannes D Veldhuis; Alan D Rogol
Longitudinal changes in growth hormone secretory process irregularity assessed transpubertally in healthy boys.
American journal of physiology. Endocrinology and metabolism 2000;279(2):E417-24.
2000: Birgit Nyholm; Niels Pørksen; Claus Juhl; Claus Gravholt; Peter C Butler; Jørgen Weeke; Johannes D Veldhuis; S Pincus; Ole Schmitz
Assessment of insulin secretion in relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus: evidence of early beta-cell dysfunction.
Metabolism: clinical and experimental 2000;49(7):896-905.
2000: Johannes D Veldhuis; James N Roemmich; Alan D Rogol
Gender and sexual maturation-dependent contrasts in the neuroregulation of growth hormone secretion in prepubertal and late adolescent males and females--a general clinical research center-based study.
The Journal of clinical endocrinology and metabolism 2000;85(7):2385-94.
2000: Friederike C Jayes; Richard N Day; James C Garmey; Randall J Urban; George Zhang; Johannes D Veldhuis
Calcium ions positively modulate follicle-stimulating hormone- and exogenous cyclic 3',5'-adenosine monophosphate-driven transcription of the P450(scc) gene in porcine granulosa cells.
Endocrinology 2000;141(7):2377-84.
2000: Matti Bergendahl; Ali Iranmanesh; T Mulligan; Johannes D Veldhuis
Impact of age on cortisol secretory dynamics basally and as driven by nutrient-withdrawal stress.
The Journal of clinical endocrinology and metabolism 2000;85(6):2203-14.
2000: C Aguirre; Friederike C Jayes; Johannes D Veldhuis
Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH.
Endocrinology 2000;141(6):2220-8.
2000: Claus Juhl; Ole Schmitz; S Pincus; J J Holst; Johannes D Veldhuis; Niels Pørksen
Short-term treatment with GLP-1 increases pulsatile insulin secretion in Type II diabetes with no effect on orderliness.
Diabetologia 2000;43(5):583-8.
2000: Claus Juhl; Niels Pørksen; Malene Hollingdal; Jeppe Sturis; S Pincus; Johannes D Veldhuis; A Dejgaard; Ole Schmitz
Repaglinide acutely amplifies pulsatile insulin secretion by augmentation of burst mass with no effect on burst frequency.
Diabetes care 2000;23(5):675-81.
2000: Daniel M Keenan; Johannes D Veldhuis
Explicating hypergonadotropism in postmenopausal women: a statistical model.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(5):R1247-57.
2000: RG Veldman; Marijke Frölich; SM Pincus; Johannes D Veldhuis; Ferdinand Roelfsema
Growth hormone and prolactin are secreted more irregularly in patients with Cushing's disease.
Clinical endocrinology 2000;52(5):625-32.
2000: Johannes D Veldhuis; Ali Iranmanesh; Michael F Godschalk; Thomas Mulligan
Older men manifest multifold synchrony disruption of reproductive neurohormone outflow.
The Journal of clinical endocrinology and metabolism 2000;85(4):1477-86.
2000: Joaquin Lado-Abeal; John R Hickox; T L Cheung; Johannes D Veldhuis; Daniel M Hardy; Reid L Norman
Neuroendocrine consequences of fasting in adult male macaques: effects of recombinant rhesus macaque leptin infusion.
Neuroendocrinology 2000;71(3):196-208.
2000: Claus Juhl; Niels Pørksen; Jeppe Sturis; A P Hansen; Johannes D Veldhuis; S Pincus; M Fineman; Ole Schmitz
High-frequency oscillations in circulating amylin concentrations in healthy humans.
American journal of physiology. Endocrinology and metabolism 2000;278(3):E484-90.
2000: James C Garmey; John A. Schnorr; ME Bruns; David Bruns; Regina M Seaner; J E Ferguson II; F C Luking Jayes; C Aguirre; Johannes D Veldhuis
Expression of parathyroid hormone-related peptide (PTH-rp) and its receptorin the porcine ovary: regulation by transforming growth factor-beta and possible paracrine effects of granulosa cell PTH-rp secretion on theca cells.
Biology of reproduction 2000;62(2):334-9.
2000: Natesampillai Sekar; James C Garmey; Johannes D Veldhuis
Mechanisms underlying the steroidogenic synergy of insulin and luteinizing hormone in porcine granulosa cells: joint amplification of pivotal sterol-regulatory genes encoding the low-density lipoprotein (LDL) receptor, steroidogenic acute regulatory (stAR) protein and cytochrome P450 side-chain cleavage (P450scc) enzyme.
Molecular and cellular endocrinology 2000;159(1-2):25-35.
2000: Johannes D Veldhuis; Michael L Johnson
Analysis of nonequilibrium facets of pulsatile sex-steroid secretion in presence of plasma-binding proteins.
Methods in enzymology 2000;321():239-63.
2000: Johannes D Veldhuis
Mechanisms and biological significance of pulsatile hormone secretion. Symposium proceedings. London, United Kingdom, 2-4 March 1999.
Novartis Foundation symposium 2000;227():1-4.
2000: Johannes D Veldhuis
Nature of altered pulsatile hormone release and neuroendocrine network signalling in human ageing: clinical studies of the somatotropic, gonadotropic, corticotropic and insulin axes.
Novartis Foundation symposium 2000;227():163-85; discussion 185-9.
2000: Niels Pørksen; Claus Juhl; Malene Hollingdal; SM Pincus; Jeppe Sturis; Johannes D Veldhuis; Ole Schmitz
Concordant induction of rapid in vivo pulsatile insulin secretion by recurrent punctuated glucose infusions.
American journal of physiology. Endocrinology and metabolism 2000;278(1):E162-70.
2000: Matti Bergendahl; Ali Iranmanesh; William S Evans; Johannes D Veldhuis
Short-term fasting selectively suppresses leptin pulse mass and 24-hour rhythmic leptin release in healthy midluteal phase women without disturbing leptin pulse frequency or its entropy control (pattern orderliness).
The Journal of clinical endocrinology and metabolism 2000;85(1):207-13.
2000: Greet Van den Berghe; Robert C Baxter; Frank Weekers; Patrick F Wouters; Cyril Y Bowers; Johannes D Veldhuis
A paradoxical gender dissociation within the growth hormone/insulin-like growth factor I axis during protracted critical illness.
The Journal of clinical endocrinology and metabolism 2000;85(1):183-92.
1999: María Gabriela Ropelato; Maria C Garcia-Rudaz; C Castro-Fernandez; A Ulloa-Aguirre; María Eugenia Escobar; Marta Barontini; Johannes D Veldhuis
A preponderance of basic luteinizing hormone (LH) isoforms accompanies inappropriate hypersecretion of both basal and pulsatile LH in adolescents with polycystic ovarian syndrome.
The Journal of clinical endocrinology and metabolism 1999;84(12):4629-36.
1999: Thomas Mulligan; A Jaen-Vinuales; Michael F Godschalk; Ali Iranmanesh; Johannes D Veldhuis
Synthetic somatostatin analog (octreotide) suppresses daytime growth hormone secretion equivalently in young and older men: preserved pituitary responsiveness to somatostatin's inhibition in aging.
Journal of the American Geriatrics Society 1999;47(12):1422-4.
1999: J A Flores; James C Garmey; M Lahav; Johannes D Veldhuis
Mechanisms underlying endothelin's inhibition of FSH-stimulated progesterone production by ovarian granulosa cells.
Molecular and cellular endocrinology 1999;156(1-2):169-78.
1999: Johannes D Veldhuis; Ali Iranmanesh; Laurence M Demers; Thomas Mulligan
Joint basal and pulsatile hypersecretory mechanisms drive the monotropic follicle-stimulating hormone (FSH) elevation in healthy older men: concurrent preservation of the orderliness of the FSH release process: a general clinical research center study.
The Journal of clinical endocrinology and metabolism 1999;84(10):3506-14.
1999: Johannes D Veldhuis; Ali Iranmanesh; Thomas Mulligan; Steven M Pincus
Disruption of the young-adult synchrony between luteinizing hormone release and oscillations in follicle-stimulating hormone, prolactin, and nocturnal penile tumescence (NPT) in healthy older men.
The Journal of clinical endocrinology and metabolism 1999;84(10):3498-505.
1999: Laurie Wideman; Judy Y Weltman; N Shah; S Story; Johannes D Veldhuis; Arthur Weltman
Effects of gender on exercise-induced growth hormone release.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;87(3):1154-62.
1999: CJ Pritzlaff; Laurie Wideman; Judy Y Weltman; RD Abbott; Margaret Gutgesell; Mark L Hartman; Johannes D Veldhuis; Arthur Weltman
Impact of acute exercise intensity on pulsatile growth hormone release in men.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;87(2):498-504.
1999: N Shah; JA Aloi; William S Evans; Johannes D Veldhuis
Time mode of growth hormone (GH) entry into the bloodstream and steady-state plasma GH concentrations, rather than sex, estradiol, or menstrual cycle stage, primarily determine the GH elimination rate in healthy young women and men.
The Journal of clinical endocrinology and metabolism 1999;84(8):2862-9.
1999: N Shah; William S Evans; Cyril Y Bowers; Johannes D Veldhuis
Tripartite neuroendocrine activation of the human growth hormone (GH) axis in women by continuous 24-hour GH-releasing peptide infusion: pulsatile, entropic, and nyctohemeral mechanisms.
The Journal of clinical endocrinology and metabolism 1999;84(6):2140-50.
1999: René K Støving; Johannes D Veldhuis; Allan Flyvbjerg; Jørgen Vinten; Jørgen Hangaard; Ole Koldkjaer; J Kristiansen; Claus Hagen
Jointly amplified basal and pulsatile growth hormone (GH) secretion and increased process irregularity in women with anorexia nervosa: indirect evidence for disruption of feedback regulation within the GH-insulin-like growth factor I axis.
The Journal of clinical endocrinology and metabolism 1999;84(6):2056-63.
1999: Graydon S Meneilly; Johannes D Veldhuis; Dariush Elahi
Disruption of the pulsatile and entropic modes of insulin release during an unvarying glucose stimulus in elderly individuals.
The Journal of clinical endocrinology and metabolism 1999;84(6):1938-43.
1999: N Shah; William S Evans; Johannes D Veldhuis
Actions of estrogen on pulsatile, nyctohemeral, and entropic modes of growth hormone secretion.
The American journal of physiology 1999;276(5 Pt 2):R1351-8.
1999: Greet Van den Berghe; Patrick F Wouters; Frank Weekers; S Mohan; Robert C Baxter; Johannes D Veldhuis; Cyril Y Bowers; Roger Bouillon
Reactivation of pituitary hormone release and metabolic improvement by infusion of growth hormone-releasing peptide and thyrotropin-releasing hormone in patients with protracted critical illness.
The Journal of clinical endocrinology and metabolism 1999;84(4):1311-23.
1999: R Groote Veldman; Gerrit van den Berg; SM Pincus; Marijke Frölich; Johannes D Veldhuis; Ferdinand Roelfsema
Increased episodic release and disorderliness of prolactin secretion in both micro- and macroprolactinomas.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(3):192-200.
1999: Matti Bergendahl; William S Evans; C Pastor; A Patel; Ali Iranmanesh; Johannes D Veldhuis
Short-term fasting suppresses leptin and (conversely) activates disorderly growth hormone secretion in midluteal phase women--a clinical research center study.
The Journal of clinical endocrinology and metabolism 1999;84(3):883-94.
1999: Johannes D Veldhuis
Recent insights into neuroendocrine mechanisms of aging of the human male hypothalamic-pituitary-gonadal axis.
Journal of andrology 1999;20(1):1-17.
1999: Greet Van den Berghe; Patrick F Wouters; Cyril Y Bowers; Francis de Zegher; Roger Bouillon; Johannes D Veldhuis
Growth hormone-releasing peptide-2 infusion synchronizes growth hormone, thyrotrophin and prolactin release in prolonged critical illness.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(1):17-22.
1999: Reinhard Feneberg; M Sparber; Johannes D Veldhuis; Otto Mehls; Eberhard Ritz; Franz Schaefer
Synchronous fluctuations of blood insulin and lactate concentrations in humans.
The Journal of clinical endocrinology and metabolism 1999;84(1):220-7.
1999: Holly A LaVoie; James C Garmey; Richard N Day; Johannes D Veldhuis
Concerted regulation of low density lipoprotein receptor gene expression by follicle-stimulating hormone and insulin-like growth factor I in porcine granulosa cells: promoter activation, messenger ribonucleic acid stability, and sterol feedback.
Endocrinology 1999;140(1):178-86.
1999: Holly A LaVoie; James C Garmey; Johannes D Veldhuis
Mechanisms of insulin-like growth factor I augmentation of follicle-stimulating hormone-induced porcine steroidogenic acute regulatory protein gene promoter activity in granulosa cells.
Endocrinology 1999;140(1):146-53.
1998: MC García-Rudaz; María Gabriela Ropelato; María Eugenia Escobar; Johannes D Veldhuis; Marta Barontini
Augmented frequency and mass of LH discharged per burst are accompanied by marked disorderliness of LH secretion in adolescents with polycystic ovary syndrome.
European journal of endocrinology / European Federation of Endocrine Societies 1998;139(6):621-30.
1998: A Giustina; Johannes D Veldhuis
Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human.
Endocrine reviews 1998;19(6):717-97.
1998: Daniel M Keenan; Johannes D Veldhuis; R Yang
Joint recovery of pulsatile and basal hormone secretion by stochastic nonlinear random-effects analysis.
The American journal of physiology 1998;275(6 Pt 2):R1939-49.
1998: Dennis W Matt; M P Gilson; T E Sales; R J Krieg; M C Kerbeshian; Johannes D Veldhuis; William S Evans
Characterization of attenuated proestrous luteinizing hormone surges in middle-aged rats by deconvolution analysis.
Biology of reproduction 1998;59(6):1477-82.
1998: Danilo Fliser; Johannes D Veldhuis; Ralf Dikow; Heinrich Schmidt-Gayk; Eberhard Ritz
Effects of acute ACE inhibition on pulsatile renin and aldosterone secretion and their synchrony.
Hypertension 1998;32(5):929-34.
1998: Claus Peter Schmitt; D Huber; Otto Mehls; J Maiwald; Günter Stein; Johannes D Veldhuis; Eberhard Ritz; Franz Schaefer
Altered instantaneous and calcium-modulated oscillatory PTH secretion patterns in patients with secondary hyperparathyroidism.
Journal of the American Society of Nephrology : JASN 1998;9(10):1832-44.
1998: T A Winters; J A Hanten; Johannes D Veldhuis
In situ amplification of the cytochrome P-450 cholesterol side-chain cleavage enzyme mRNA in single porcine granulosa cells by IGF-1 and FSH acting alone or in concert.
Endocrine 1998;9(1):57-63.
1998: William G Goodman; Johannes D Veldhuis; TR Belin; Andre J Van Herle; H Juppner; Isidro B Salusky
Calcium-sensing by parathyroid glands in secondary hyperparathyroidism.
The Journal of clinical endocrinology and metabolism 1998;83(8):2765-72.
1998: J A Flores; C Aguirre; O P Sharma; Johannes D Veldhuis
Luteinizing hormone (LH) stimulates both intracellular calcium ion ([Ca2+]i) mobilization and transmembrane cation influx in single ovarian (granulosa) cells: recruitment as a cellular mechanism of LH-[Ca2+]i dose response.
Endocrinology 1998;139(8):3606-12.
1998: A Iranmanesh; S South; A Y Liem; David R Clemmons; M O Thorner; Arthur Weltman; Johannes D Veldhuis
Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotrophic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth hormone-releasing hormone pulsatile infusion in men.
European journal of endocrinology / European Federation of Endocrine Societies 1998;139(1):59-71.
1998: Daniel M Keenan; Johannes D Veldhuis
A biomathematical model of time-delayed feedback in the human male hypothalamic-pituitary-Leydig cell axis.
The American journal of physiology 1998;275(1 Pt 1):E157-76.
1998: Arthur Weltman; Judy Y Weltman; Jill A Kanaley; Alan D Rogol; Johannes D Veldhuis
Repeated bouts of exercise alter the blood lactate-RPE relation.
Medicine and science in sports and exercise 1998;30(7):1113-7.
1998: Benedict J Canny; I Ross Young; Johannes D Veldhuis
Hypothalamo-pituitary disconnection of the late-gestation ovine fetus results in profound changes in cortisol secretion that are not reflected in commensurate changes in adrenocorticotropin secretion.
Endocrinology 1998;139(7):3210-9.
1998: Matti Bergendahl; JA Aloi; Ali Iranmanesh; T M Mulligan; Johannes D Veldhuis
Fasting suppresses pulsatile luteinizing hormone (LH) secretion and enhances orderliness of LH release in young but not older men.
The Journal of clinical endocrinology and metabolism 1998;83(6):1967-75.
1998: Ferdinand Roelfsema; Gerrit van den Berg; Hans van Dulken; Johannes D Veldhuis; SM Pincus
Pituitary apoplexy in acromegaly, a long-term follow-up study in two patients.
Journal of endocrinological investigation 1998;21(5):298-303.
1998: R Roubenoff; Laura C Rall; Johannes D Veldhuis; Joseph J Kehayias; C Rosen; M Nicolson; Nancy T Lundgren; Seymour Reichlin
The relationship between growth hormone kinetics and sarcopenia in postmenopausal women: the role of fat mass and leptin.
The Journal of clinical endocrinology and metabolism 1998;83(5):1502-6.
1998: James N Roemmich; Pamela A Clark; V Mai; Stuart S Berr; Arthur Weltman; Johannes D Veldhuis; Alan D Rogol
Alterations in growth and body composition during puberty: III. Influence of maturation, gender, body composition, fat distribution, aerobic fitness, and energy expenditure on nocturnal growth hormone release.
The Journal of clinical endocrinology and metabolism 1998;83(5):1440-7.
1998: Johannes D Veldhuis
Neuroendocrine control of pulsatile growth hormone release in the human: relationship with gender.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1998;8 Suppl B():49-59.
1998: Johannes D Veldhuis; Steven M Pincus
Orderliness of hormone release patterns: a complementary measure to conventional pulsatile and circadian analyses.
European journal of endocrinology / European Federation of Endocrine Societies 1998;138(4):358-62.
1998: Dennis W Matt; Scott W Kauma; Steven M Pincus; Johannes D Veldhuis; William S Evans
Characteristics of luteinizing hormone secretion in younger versus older premenopausal women.
American journal of obstetrics and gynecology 1998;178(3):504-10.
1998: Gerrit van den Berg; SM Pincus; Marijke Frölich; Johannes D Veldhuis; Ferdinand Roelfsema
Reduced disorderliness of growth hormone release in biochemically inactive acromegaly after pituitary surgery.
European journal of endocrinology / European Federation of Endocrine Societies 1998;138(2):164-9.
1998: Ferdinand Roelfsema; SM Pincus; Johannes D Veldhuis
Patients with Cushing's disease secrete adrenocorticotropin and cortisol jointly more asynchronously than healthy subjects.
The Journal of clinical endocrinology and metabolism 1998;83(2):688-92.
1998: Greet Van den Berghe; Francis de Zegher; Robert C Baxter; Johannes D Veldhuis; Patrick F Wouters; Miet Schetz; Charles Verwaest; E Van der Vorst; Peter Lauwers; Roger Bouillon; Cyril Y Bowers
Neuroendocrinology of prolonged critical illness: effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues.
The Journal of clinical endocrinology and metabolism 1998;83(2):309-19.
1998: Claus Peter Schmitt; Franz Schaefer; D Huber; I Zahn; Johannes D Veldhuis; Eberhard Ritz; Otto Mehls
1,25(OH)2-vitamin D3 reduces spontaneous and hypocalcemia-stimulated pulsatile component of parathyroid hormone secretion.
Journal of the American Society of Nephrology : JASN 1998;9(1):54-62.
1998: Niels Pørksen; B Grøfte; Birgit Nyholm; J J Holst; SM Pincus; Johannes D Veldhuis; Ole Schmitz; Peter C Butler
Glucagon-like peptide 1 increases mass but not frequency or orderliness of pulsatile insulin secretion.
Diabetes 1998;47(1):45-9.
1997: Graydon S Meneilly; Alice S Ryan; Johannes D Veldhuis; Dariush Elahi
Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals.
The Journal of clinical endocrinology and metabolism 1997;82(12):4088-93.
1997: Greet Van den Berghe; Francis de Zegher; Johannes D Veldhuis; Patrick F Wouters; S Gouwy; W Stockman; Frank Weekers; Miet Schetz; Peter Lauwers; Roger Bouillon; Cyril Y Bowers
Thyrotrophin and prolactin release in prolonged critical illness: dynamics of spontaneous secretion and effects of growth hormone-secretagogues.
Clinical endocrinology 1997;47(5):599-612.
1997: Jill A Kanaley; Judy Y Weltman; Johannes D Veldhuis; Alan D Rogol; Mark L Hartman; Arthur Weltman
Human growth hormone response to repeated bouts of aerobic exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;83(5):1756-61.
1997: Steven M Pincus; Johannes D Veldhuis; Thomas Mulligan; Ali Iranmanesh; William S Evans
Effects of age on the irregularity of LH and FSH serum concentrations in women and men.
The American journal of physiology 1997;273(5 Pt 1):E989-95.
1997: Niels Pørksen; Birgit Nyholm; Johannes D Veldhuis; Peter C Butler; Ole Schmitz
In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts.
The American journal of physiology 1997;273(5 Pt 1):E908-14.
1997: Danilo Fliser; Franz Schaefer; D Schmid; Johannes D Veldhuis; Eberhard Ritz
Angiotensin II affects basal, pulsatile, and glucose-stimulated insulin secretion in humans.
Hypertension 1997;30(5):1156-61.
1997: David A Fryburg; Arthur Weltman; Linda A Jahn; Judy Y Weltman; E Samojlik; R L Hintz; Johannes D Veldhuis
Short-term modulation of the androgen milieu alters pulsatile, but not exercise- or growth hormone (GH)-releasing hormone-stimulated GH secretion in healthy men: impact of gonadal steroid and GH secretory changes on metabolic outcomes.
The Journal of clinical endocrinology and metabolism 1997;82(11):3710-9.
1997: F Sun; D J Berry; D A Leong; Johannes D Veldhuis
Recruitment of individually (all-or-none) responding cells, rather than amplitude enhancement, is the single-cell mechanism subserving the dose-responsive activation of intracellular calcium second messenger signaling by the human luteinizing-hormone receptor.
Endocrine 1997;7(2):219-26.
1997: K Friend; Ali Iranmanesh; I S Login; Johannes D Veldhuis
Pyridostigmine treatment selectively amplifies the mass of GH secreted per burst without altering GH burst frequency, half-life, basal GH secretion or the orderliness of GH release.
European journal of endocrinology / European Federation of Endocrine Societies 1997;137(4):377-86.
1997: Johannes D Veldhuis; D L Metzger; P M Martha; Nelly Mauras; J R Kerrigan; B Keenan; Alan D Rogol; Steven M Pincus
Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement.
The Journal of clinical endocrinology and metabolism 1997;82(10):3414-20.
1997: Daniel M Keenan; Johannes D Veldhuis
Stochastic model of admixed basal and pulsatile hormone secretion as modulated by a deterministic oscillator.
The American journal of physiology 1997;273(3 Pt 2):R1182-92.
1997: Pamela A Clark; Ali Iranmanesh; Johannes D Veldhuis; Alan D Rogol
Comparison of pulsatile luteinizing hormone secretion between prepubertal children and young adults: evidence for a mass/amplitude-dependent difference without gender or day/night contrasts.
The Journal of clinical endocrinology and metabolism 1997;82(9):2950-5.
1997: Johannes D Veldhuis; Ali Iranmanesh; Arthur Weltman
Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans.
Endocrine 1997;7(1):41-8.
1997: Holly A LaVoie; Allison M Benoit; James C Garmey; R A Dailey; D J Wright; Johannes D Veldhuis
Coordinate developmental expression of genes regulating sterol economy and cholesterol side-chain cleavage in the porcine ovary.
Biology of reproduction 1997;57(2):402-7.
1997: AD Zwart; Ali Iranmanesh; Johannes D Veldhuis
Disparate serum free testosterone concentrations and degrees of hypothalamo-pituitary-luteinizing hormone suppression are achieved by continuous versus pulsatile intravenous androgen replacement in men: a clinical experimental model of ketoconazole-induced reversible hypoandrogenemia with controlled testosterone add-back.
The Journal of clinical endocrinology and metabolism 1997;82(7):2062-9.
1997: William G Goodman; Johannes D Veldhuis; TR Belin; H Juppner; Isidro B Salusky
Suppressive effect of calcium on parathyroid hormone release in adynamic renal osteodystrophy and secondary hyperparathyroidism.
Kidney international 1997;51(5):1590-5.
1997: JA Aloi; Matti Bergendahl; Ali Iranmanesh; Johannes D Veldhuis
Pulsatile intravenous gonadotropin-releasing hormone administration averts fasting-induced hypogonadotropism and hypoandrogenemia in healthy, normal weight men.
The Journal of clinical endocrinology and metabolism 1997;82(5):1543-8.
1997: Johannes D Veldhuis
How does one get at glandular secretion, when only hormone concentrations are measured?
Clinical endocrinology 1997;46(4):397-400.
1997: Gerrit van den Berg; SM Pincus; Johannes D Veldhuis; Marijke Frölich; Ferdinand Roelfsema
Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing's disease.
European journal of endocrinology / European Federation of Endocrine Societies 1997;136(4):394-400.
1997: Johannes D Veldhuis; Ali Iranmanesh; E Samojlik; Randall J Urban
Differential sex steroid negative feedback regulation of pulsatile follicle-stimulating hormone secretion in healthy older men: deconvolution analysis and steady-state sex-steroid hormone infusions in frequently sampled healthy older individuals.
The Journal of clinical endocrinology and metabolism 1997;82(4):1248-54.
1997: Andrea Giustina; T Scalvini; Carmelo Tassi; P Desenzani; Claudio Poiesi; William B Wehrenberg; Alan D Rogol; Johannes D Veldhuis
Maturation of the regulation of growth hormone secretion in young males with hypogonadotropic hypogonadism pharmacologically exposed to progressive increments in serum testosterone.
The Journal of clinical endocrinology and metabolism 1997;82(4):1210-9.
1997: Niels Pørksen; Mehboob A Hussain; Tarcisio Bianda; Birgit Nyholm; Jens Sandahl Christiansen; Peter C Butler; Johannes D Veldhuis; ER Froesch; Ole Schmitz
IGF-I inhibits burst mass of pulsatile insulin secretion at supraphysiological and low IGF-I infusion rates.
The American journal of physiology 1997;272(3 Pt 1):E352-8.
1997: Johannes D Veldhuis; AD Zwart; Ali Iranmanesh
Neuroendocrine mechanisms by which selective Leydig cell castration unleashes increased pulsatile LH release.
The American journal of physiology 1997;272(2 Pt 2):R464-74.
1997: Ole Schmitz; Niels Pørksen; Birgit Nyholm; Christian Skjaerbaek; Peter C Butler; Johannes D Veldhuis; SM Pincus
Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM.
The American journal of physiology 1997;272(2 Pt 1):E218-26.
1997: Greet Van den Berghe; Francis de Zegher; Johannes D Veldhuis; Patrick F Wouters; M Awouters; W Verbruggen; Miet Schetz; Charles Verwaest; Peter Lauwers; Roger Bouillon; Cyril Y Bowers
The somatotropic axis in critical illness: effect of continuous growth hormone (GH)-releasing hormone and GH-releasing peptide-2 infusion.
The Journal of clinical endocrinology and metabolism 1997;82(2):590-9.
1997: Johannes D Veldhuis; J A Norton; S A Wells; A I Vinik; R R Perry
Surgical versus medical management of multiple endocrine neoplasia (MEN) type I.
The Journal of clinical endocrinology and metabolism 1997;82(2):357-64.
1997: K Balasubramanian; Holly A LaVoie; James C Garmey; D M Stocco; Johannes D Veldhuis
Regulation of porcine granulosa cell steroidogenic acute regulatory protein (StAR) by insulin-like growth factor I: synergism with follicle-stimulating hormone or protein kinase A agonist.
Endocrinology 1997;138(1):433-9.
1996: Johannes D Veldhuis; Ali Iranmanesh
Physiological regulation of the human growth hormone (GH)-insulin-like growth factor type I (IGF-I) axis: predominant impact of age, obesity, gonadal function, and sleep.
Sleep 1996;19(10 Suppl):S221-4.
1996: Ian M Chapman; M A Bach; E Van Cauter; M Farmer; David Krupa; A M Taylor; L M Schilling; K Y Cole; E H Skiles; Suzan S Pezzoli; Mark L Hartman; Johannes D Veldhuis; G J Gormley; Michael O Thorner
Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.
The Journal of clinical endocrinology and metabolism 1996;81(12):4249-57.
1996: Claus Peter Schmitt; Franz Schaefer; A Bruch; Johannes D Veldhuis; Heinrich Schmidt-Gayk; Günter Stein; Eberhard Ritz; Otto Mehls
Control of pulsatile and tonic parathyroid hormone secretion by ionized calcium.
The Journal of clinical endocrinology and metabolism 1996;81(12):4236-43.
1996: M L Johnson; Johannes D Veldhuis; M Lampl
Is growth saltatory? The usefulness and limitations of frequency distributions in analyzing pulsatile data.
Endocrinology 1996;137(12):5197-204.
1996: S M Pincus; Thomas Mulligan; Ali Iranmanesh; S Gheorghiu; Michael F Godschalk; Johannes D Veldhuis
Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14100-5.
1996: Matti Bergendahl; W S Evans; Johannes D Veldhuis
Current concepts on ultradian rhythms of luteinizing hormone secretion in the human.
Human reproduction update 1996;2(6):507-18.
1996: PM Martha; Alan D Rogol; Johannes D Veldhuis; R M Blizzard
A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. III. The neuroendocrine growth hormone axis during late prepuberty.
The Journal of clinical endocrinology and metabolism 1996;81(11):4068-74.
1996: A D Zwart; Randall J Urban; W D Odell; Johannes D Veldhuis
Contrasts in the gonadotropin-releasing hormone dose-response relationships for luteinizing hormone, follicle-stimulating hormone and alpha-subunit release in young versus older men: appraisal with high-specificity immunoradiometric assay and deconvolution analysis.
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(4):399-406.
1996: Keith E Friend; Ali Iranmanesh; Johannes D Veldhuis
The orderliness of the growth hormone (GH) release process and the mean mass of GH secreted per burst are highly conserved in individual men on successive days.
The Journal of clinical endocrinology and metabolism 1996;81(10):3746-53.
1996: R A Booth; Judy Y Weltman; V I Yankov; J Murray; T S Davison; Alan D Rogol; C M Asplin; M L Johnson; Johannes D Veldhuis; William S Evans
Mode of pulsatile follicle-stimulating hormone secretion in gonadal hormone-sufficient and -deficient women--a clinical research center study.
The Journal of clinical endocrinology and metabolism 1996;81(9):3208-14.
1996: Gerrit van den Berg; Johannes D Veldhuis; Marijke Frölich; Ferdinand Roelfsema
An amplitude-specific divergence in the pulsatile mode of growth hormone (GH) secretion underlies the gender difference in mean GH concentrations in men and premenopausal women.
The Journal of clinical endocrinology and metabolism 1996;81(7):2460-7.
1996: Johannes D Veldhuis
Neuroendocrine mechanisms mediating awakening of the human gonadotropic axis in puberty.
Pediatric nephrology (Berlin, Germany) 1996;10(3):304-17.
1996: M Lahav; James C Garmey; Johannes D Veldhuis
Paradoxical effect of 3-isobutyl-1-methylxanthine on cytochrome P450 cholesterol side-chain cleavage mRNA accumulation in porcine granulosa cells.
Molecular and cellular endocrinology 1996;117(2):203-10.
1996: NM Wright; N Papadea; Steven M Willi; Johannes D Veldhuis; Janardan P Pandey; L Lyndon Key; Norman H Bell
Demonstration of a lack of racial difference in secretion of growth hormone despite a racial difference in bone mineral density in premenopausal women--a Clinical Research Center study.
The Journal of clinical endocrinology and metabolism 1996;81(3):1023-6.
1996: Johannes D Veldhuis
Gender differences in secretory activity of the human somatotropic (growth hormone) axis.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(3):287-95.
1996: Matti Bergendahl; Mary Lee Vance; Ali Iranmanesh; Michael O Thorner; Johannes D Veldhuis
Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men.
The Journal of clinical endocrinology and metabolism 1996;81(2):692-9.
1996: A Reyes-Fuentes; María Eugenia Chavarría; A Carrera; G Aguilera; A Rosado; E Samojlik; Ali Iranmanesh; Johannes D Veldhuis
Alterations in pulsatile luteinizing hormone and follicle-stimulating hormone secretion in idiopathic oligoasthenospermic men: assessment by deconvolution analysis--a clinical research center study.
The Journal of clinical endocrinology and metabolism 1996;81(2):524-9.
1996: S M Pincus; Evelien Gevers; Iain C A F Robinson; G van den Berg; Ferdinand Roelfsema; Mark L Hartman; Johannes D Veldhuis
Females secrete growth hormone with more process irregularity than males in both humans and rats.
The American journal of physiology 1996;270(1 Pt 1):E107-15.
1996: Franz Schaefer; G Baumann; D Haffner; L M Faunt; M L Johnson; M Mercado; Eberhard Ritz; Otto Mehls; Johannes D Veldhuis
Multifactorial control of the elimination kinetics of unbound (free) growth hormone (GH) in the human: regulation by age, adiposity, renal function, and steady state concentrations of GH in plasma.
The Journal of clinical endocrinology and metabolism 1996;81(1):22-31.
1995: Gerrit van den Berg; Marijke Frölich; Johannes D Veldhuis; Ferdinand Roelfsema
Combined amplification of the pulsatile and basal modes of adrenocorticotropin and cortisol secretion in patients with Cushing's disease: evidence for decreased responsiveness of the adrenal glands.
The Journal of clinical endocrinology and metabolism 1995;80(12):3750-7.
1995: Johannes D Veldhuis; A Y Liem; S South; Arthur Weltman; Judy Y Weltman; D A Clemmons; R Abbott; Thomas Mulligan; M L Johnson; S Pincus
Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay.
The Journal of clinical endocrinology and metabolism 1995;80(11):3209-22.
1995: A Maitra; Holly A LaVoie; Richard N Day; James C Garmey; Johannes D Veldhuis
Regulation of porcine granulosa cell 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin and insulin-like growth factor I: synergism with follicle-stimulating hormone or protein kinase A agonist.
Endocrinology 1995;136(11):5111-7.
1995: J A Flores; T A Winters; J W Knight; Johannes D Veldhuis
Nature of endothelin binding in the porcine ovary.
Endocrinology 1995;136(11):5014-9.
1995: Thomas Mulligan; Ali Iranmanesh; S Gheorghiu; Michael F Godschalk; Johannes D Veldhuis
Amplified nocturnal luteinizing hormone (LH) secretory burst frequency with selective attenuation of pulsatile (but not basal) testosterone secretion in healthy aged men: possible Leydig cell desensitization to endogenous LH signaling--a clinical research center study.
The Journal of clinical endocrinology and metabolism 1995;80(10):3025-31.
1995: NM Wright; J Renault; Steven M Willi; Johannes D Veldhuis; Janardan P Pandey; Leonie Gordon; L Lyndon Key; Norman H Bell
Greater secretion of growth hormone in black than in white men: possible factor in greater bone mineral density--a clinical research center study.
The Journal of clinical endocrinology and metabolism 1995;80(8):2291-7.
1995: Allison M Benoit; Johannes D Veldhuis
Differential effects of pulsatile versus continuous follicle-stimulating hormone delivery on the production of cyclic adenosine 5'-monophosphates and the accumulation of cytochrome P450 cholesterol side-chain cleavage enzyme mRNA in perifused porcine granulosa cells.
Biology of reproduction 1995;53(1):46-54.
1995: M Lahav; James C Garmey; Margaret A Shupnik; Johannes D Veldhuis
Dual actions of phorbol ester on cytochrome P450 cholesterol side-chain cleavage messenger ribonucleic acid accumulation in porcine granulosa cells.
Biology of reproduction 1995;52(5):972-81.
1995: E Chavarría; A Reyes; A Carrera; G Aguilera; A Rosado; Johannes D Veldhuis
[Kinetic study of pulsatility of gonadotropin and testosterone secretion in normospermic fertile and infertile men with idiopathic oligo-asthenozoospermia].
Ginecología y obstetricia de México 1995;63():74-89.
1995: Helmy M Siragy; W V Vieweg; S Pincus; Johannes D Veldhuis
Increased disorderliness and amplified basal and pulsatile aldosterone secretion in patients with primary aldosteronism.
The Journal of clinical endocrinology and metabolism 1995;80(1):28-33.
1994: Johannes D Veldhuis; Randall J Urban; M L Dufau
Differential responses of biologically active luteinizing hormone secretion in older versus young men to interruption of androgen negative feedback.
The Journal of clinical endocrinology and metabolism 1994;79(6):1763-70.
1994: Gerrit van den Berg; Marijke Frölich; Johannes D Veldhuis; Ferdinand Roelfsema
Growth hormone secretion in recently operated acromegalic patients.
The Journal of clinical endocrinology and metabolism 1994;79(6):1706-15.
1994: Johannes D Veldhuis; Ali Iranmanesh; M J Wilkowski; E Samojlik
Neuroendocrine alterations in the somatotropic and lactotropic axes in uremic men.
European journal of endocrinology / European Federation of Endocrine Societies 1994;131(5):489-98.
1994: Franz Schaefer; B van Kaick; Johannes D Veldhuis; Günter Stein; K Schärer; W R Robertson; Eberhard Ritz
Changes in the kinetics and biopotency of luteinizing hormone in hemodialyzed men during treatment with recombinant human erythropoietin.
Journal of the American Society of Nephrology : JASN 1994;5(5):1208-15.
1994: Greet Van den Berghe; Francis de Zegher; Peter Lauwers; Johannes D Veldhuis
Luteinizing hormone secretion and hypoandrogenaemia in critically ill men: effect of dopamine.
Clinical endocrinology 1994;41(5):563-9.
1994: Greet Van den Berghe; Francis de Zegher; Peter Lauwers; Johannes D Veldhuis
Growth hormone secretion in critical illness: effect of dopamine.
The Journal of clinical endocrinology and metabolism 1994;79(4):1141-6.
1994: M L Griffin; S A South; V I Yankov; R A Booth; C M Asplin; Johannes D Veldhuis; William S Evans
Insulin-dependent diabetes mellitus and menstrual dysfunction.
Annals of medicine 1994;26(5):331-40.
1994: Mark L Hartman; S M Pincus; M L Johnson; D H Matthews; L M Faunt; Mary Lee Vance; Michael O Thorner; Johannes D Veldhuis
Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release.
The Journal of clinical investigation 1994;94(3):1277-88.
1994: Francis de Zegher; Christine Vanhole; Greet Van den Berghe; Hugo Devlieger; E Eggermont; Johannes D Veldhuis
Properties of thyroid-stimulating hormone and cortisol secretion by the human newborn on the day of birth.
The Journal of clinical endocrinology and metabolism 1994;79(2):576-81.
1994: A S Loudon; N L Wayne; R Krieg; Ali Iranmanesh; Johannes D Veldhuis; Michael Menaker
Ultradian endocrine rhythms are altered by a circadian mutation in the Syrian hamster.
Endocrinology 1994;135(2):712-8.
1994: O P Sharma; J A Flores; D A Leong; Johannes D Veldhuis
Mechanisms by which endothelin-1 stimulates increased cytosolic free calcium ion concentrations in single rat Sertoli cells.
Endocrinology 1994;135(1):127-34.
1994: Johannes D Veldhuis; Ali Iranmanesh; G Lizarralde; Randall J Urban
Combined deficits in the somatotropic and gonadotropic axes in healthy aging men: an appraisal of neuroendocrine mechanisms by deconvolution analysis.
Neurobiology of aging 1994;15(4):509-17.
1994: Ian M Chapman; Mark L Hartman; Martin Straume; M L Johnson; Johannes D Veldhuis; Michael O Thorner
Enhanced sensitivity growth hormone (GH) chemiluminescence assay reveals lower postglucose nadir GH concentrations in men than women.
The Journal of clinical endocrinology and metabolism 1994;78(6):1312-9.
1994: O P Sharma; J A Flores; D A Leong; Johannes D Veldhuis
Cellular basis for follicle-stimulating hormone-stimulated calcium signaling in single rat Sertoli cells: possible dissociation from effects of adenosine 3',5'-monophosphate.
Endocrinology 1994;134(4):1915-23.
1994: Franz Schaefer; Markus Daschner; Johannes D Veldhuis; J Oh; F Qadri; K Schärer
In vivo alterations in the gonadotropin-releasing hormone pulse generator and the secretion and clearance of luteinizing hormone in the uremic castrate rat.
Neuroendocrinology 1994;59(3):285-96.
1994: Arthur Weltman; Judy Y Weltman; Mark L Hartman; R D Abbott; Alan D Rogol; William S Evans; Johannes D Veldhuis
Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: effects of gender.
The Journal of clinical endocrinology and metabolism 1994;78(3):543-8.
1994: J R Kerrigan; Johannes D Veldhuis; Alan D Rogol
Androgen-receptor blockade enhances pulsatile luteinizing hormone production in late pubertal males: evidence for a hypothalamic site of physiologic androgen feedback action.
Pediatric research 1994;35(1):102-6.
1994: Johannes D Veldhuis; M L Johnson
Testing pulse detection algorithms with simulations of episodically pulsatile substrate, metabolite, or hormone release.
Methods in enzymology 1994;240():377-415.
1994: Johannes D Veldhuis; L M Faunt; M L Johnson
Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins.
Methods in enzymology 1994;240():349-77.
1994: Martin Straume; Johannes D Veldhuis; M L Johnson
Model-independent quantification of measurement error: empirical estimation of discrete variance function profiles based on standard curves.
Methods in enzymology 1994;240():121-50.
1994: Johannes D Veldhuis; M L Johnson
Analytical methods for evaluating episodic secretory activity within neuroendocrine axes.
Neuroscience and biobehavioral reviews 1994;18(4):605-12.
1993: F Nieves-Rivera; J R Kerrigan; Richard J Krieg; J Egan; L J Hwang; E Truumees; Johannes D Veldhuis; William S Evans; Alan D Rogol
Altered growth hormone (GH) secretion in vivo and in vitro in the diabetes-prone BB/Worcester rat.
Growth regulation 1993;3(4):235-44.
1993: Francis de Zegher; Greet Van den Berghe; Hugo Devlieger; E Eggermont; Johannes D Veldhuis
Dopamine inhibits growth hormone and prolactin secretion in the human newborn.
Pediatric research 1993;34(5):642-5.
1993: F Nieves-Rivera; Alan D Rogol; Johannes D Veldhuis; D K Branscom; PM Martha; William L Clarke
Alterations in growth hormone secretion and clearance in adolescent boys with insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1993;77(3):638-43.
1993: D L Metzger; NM Wright; Johannes D Veldhuis; Alan D Rogol; J R Kerrigan
Characterization of pulsatile secretion and clearance of plasma cortisol in premature and term neonates using deconvolution analysis.
The Journal of clinical endocrinology and metabolism 1993;77(2):458-63.
1993: James C Garmey; Richard N Day; K H Day; Johannes D Veldhuis
Mechanisms of regulation of ovarian sterol metabolism by insulin-like growth factor type II: in vitro studies with swine granulosa cells.
Endocrinology 1993;133(2):800-8.
1993: D L Thompson; Judy Y Weltman; Alan D Rogol; D L Metzger; Johannes D Veldhuis; Arthur Weltman
Cholinergic and opioid involvement in release of growth hormone during exercise and recovery.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(2):870-8.
1993: Ferdinand Roelfsema; Gerrit van den Berg; Marijke Frölich; Johannes D Veldhuis; A van Eijk; M M Buurman; B H Etman
Sex-dependent alteration in cortisol response to endogenous adrenocorticotropin.
The Journal of clinical endocrinology and metabolism 1993;77(1):234-40.
1993: Johannes D Veldhuis; M L Johnson; R V Gallo
Reanalysis of the rat proestrous LH surge by deconvolution analysis.
The American journal of physiology 1993;265(1 Pt 2):R240-5.
1993: J R Kerrigan; Johannes D Veldhuis; S A Leyo; Ali Iranmanesh; Alan D Rogol
Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis.
The Journal of clinical endocrinology and metabolism 1993;76(6):1505-10.
1993: Ali Iranmanesh; G Lizarralde; Johannes D Veldhuis
Coordinate activation of the corticotropic axis by insulin-induced hypoglycemia: simultaneous estimates of beta-endorphin, adrenocorticotropin and cortisol secretion and disappearance in normal men.
Acta endocrinologica 1993;128(6):521-8.
1993: Francis de Zegher; Hugo Devlieger; Johannes D Veldhuis
Properties of growth hormone and prolactin hypersecretion by the human infant on the day of birth.
The Journal of clinical endocrinology and metabolism 1993;76(5):1177-81.
1993: J A Flores; James C Garmey; J E Nestler; Johannes D Veldhuis
Sites of inhibition of steroidogenesis by activation of protein kinase-C in swine ovarian (granulosa) cells.
Endocrinology 1993;132(5):1983-90.
1993: S A South; C M Asplin; E C Carlsen; R A Booth; Judy Y Weltman; M L Johnson; Johannes D Veldhuis; William S Evans
Alterations in luteinizing hormone secretory activity in women with insulin-dependent diabetes mellitus and secondary amenorrhea.
The Journal of clinical endocrinology and metabolism 1993;76(4):1048-53.
1993: J R Kerrigan; PM Martha; Johannes D Veldhuis; R M Blizzard; Alan D Rogol
Altered growth hormone secretory dynamics in prepubertal males with constitutional delay of growth.
Pediatric research 1993;33(3):278-83.
1993: Johannes D Veldhuis; M J Wilkowski; A D Zwart; Randall J Urban; G Lizarralde; Ali Iranmanesh; W K Bolton
Evidence for attenuation of hypothalamic gonadotropin-releasing hormone (GnRH) impulse strength with preservation of GnRH pulse frequency in men with chronic renal failure.
The Journal of clinical endocrinology and metabolism 1993;76(3):648-54.
1993: S A Quyyumi; JoAnn V Pinkerton; William S Evans; Johannes D Veldhuis
Estradiol amplifies the amount of luteinizing hormone (LH) secreted in response to increasing doses of gonadotropin-releasing hormone by specifically augmenting the duration of evoked LH secretory events and hence their mass.
The Journal of clinical endocrinology and metabolism 1993;76(3):594-600.
1993: Johannes D Veldhuis; Ali Iranmanesh; William S Evans; G Lizarralde; Michael O Thorner; Mary Lee Vance
Amplitude suppression of the pulsatile mode of immunoradiometric luteinizing hormone release in fasting-induced hypoandrogenemia in normal men.
The Journal of clinical endocrinology and metabolism 1993;76(3):587-93.
1993: Johannes D Veldhuis; M L Johnson; L M Faunt; M Mercado; G Baumann
Influence of the high-affinity growth hormone (GH)-binding protein on plasma profiles of free and bound GH and on the apparent half-life of GH. Modeling analysis and clinical applications.
The Journal of clinical investigation 1993;91(2):629-41.
1992: Alan D Rogol; Judy Y Weltman; William S Evans; Johannes D Veldhuis; A L Weltman
Long-term endurance training alters the hypothalamic-pituitary axes for gonadotropins and growth hormone.
Endocrinology and metabolism clinics of North America 1992;21(4):817-32.
1992: Francis de Zegher; Hugo Devlieger; Johannes D Veldhuis
Pulsatile and sexually dimorphic secretion of luteinizing hormone in the human infant on the day of birth.
Pediatric research 1992;32(5):605-7.
1992: D B Snead; C C Stubbs; Judy Y Weltman; William S Evans; Johannes D Veldhuis; Alan D Rogol; C David Teates; Arthur Weltman
Dietary patterns, eating behaviors, and bone mineral density in women runners.
The American journal of clinical nutrition 1992;56(4):705-11.
1992: LISA KOLP; S N Pavlou; Randall J Urban; J C Rivier; W W Vale; Johannes D Veldhuis
Abrogation by a potent gonadotropin-releasing hormone antagonist of the estrogen/progesterone-stimulated surge-like release of luteinizing hormone and follicle-stimulating hormone in postmenopausal women.
The Journal of clinical endocrinology and metabolism 1992;75(4):993-7.
1992: Johannes D Veldhuis; M L Johnson; G Lizarralde; Ali Iranmanesh
Rhythmic and nonrhythmic modes of anterior pituitary gland secretion.
Chronobiology international 1992;9(5):371-9.
1992: Johannes D Veldhuis; Randall J Urban; G Lizarralde; M L Johnson; Ali Iranmanesh
Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men.
The Journal of clinical endocrinology and metabolism 1992;75(3):707-13.
1992: NM Wright; Frances J Northington; J D Miller; Johannes D Veldhuis; Alan D Rogol
Elevated growth hormone secretory rate in premature infants: deconvolution analysis of pulsatile growth hormone secretion in the neonate.
Pediatric research 1992;32(3):286-90.
1992: J A Flores; S Quyyumi; D A Leong; Johannes D Veldhuis
Actions of endothelin-1 on swine ovarian (granulosa) cells.
Endocrinology 1992;131(3):1350-8.
1992: Arthur Weltman; Judy Y Weltman; R Schurrer; William S Evans; Johannes D Veldhuis; Alan D Rogol
Endurance training amplifies the pulsatile release of growth hormone: effects of training intensity.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(6):2188-96.
1992: Johannes D Veldhuis; Randall J Urban; M L Dufau
Evidence that androgen negative feedback regulates hypothalamic gonadotropin-releasing hormone impulse strength and the burst-like secretion of biologically active luteinizing hormone in men.
The Journal of clinical endocrinology and metabolism 1992;74(6):1227-35.
1992: A C Faria; L W Bekenstein; R A Booth; V A Vaccaro; C M Asplin; Johannes D Veldhuis; Michael O Thorner; William S Evans
Pulsatile growth hormone release in normal women during the menstrual cycle.
Clinical endocrinology 1992;36(6):591-6.
1992: D B Snead; Arthur Weltman; Judy Y Weltman; William S Evans; Johannes D Veldhuis; M M Varma; C David Teates; E A Dowling; Alan D Rogol
Reproductive hormones and bone mineral density in women runners.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(6):2149-56.
1992: W V Vieweg; Johannes D Veldhuis; Robert M Carey
Temporal pattern of renin and aldosterone secretion in men: effects of sodium balance.
The American journal of physiology 1992;262(5 Pt 2):F871-7.
1992: Arthur Weltman; R L Seip; D Snead; Judy Y Weltman; E M Haskvitz; William S Evans; Johannes D Veldhuis; Alan D Rogol
Exercise training at and above the lactate threshold in previously untrained women.
International journal of sports medicine 1992;13(3):257-63.
1992: Mark L Hartman; Johannes D Veldhuis; M L Johnson; M M Lee; K G Alberti; E Samojlik; Michael O Thorner
Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men.
The Journal of clinical endocrinology and metabolism 1992;74(4):757-65.
1992: J A Flores; D A Leong; Johannes D Veldhuis
Is the calcium signal induced by follicle-stimulating hormone in swine granulosa cells mediated by adenosine cyclic 3',5'-monophosphate-dependent protein kinase?
Endocrinology 1992;130(4):1862-6.
1992: Ali Iranmanesh; G Lizarralde; Johannes D Veldhuis
Robustness of the male lactotropic axis to the hyperprolactinemic stimulus of primary thyroidal failure.
The Journal of clinical endocrinology and metabolism 1992;74(3):559-64.
1992: Johannes D Veldhuis; M L Johnson; E Seneta; Ali Iranmanesh
Temporal coupling among luteinizing hormone, follicle stimulating hormone, beta-endorphin and cortisol pulse episodes in vivo.
Acta endocrinologica 1992;126(3):193-200.
1992: PM Martha; K M Gorman; R M Blizzard; Alan D Rogol; Johannes D Veldhuis
Endogenous growth hormone secretion and clearance rates in normal boys, as determined by deconvolution analysis: relationship to age, pubertal status, and body mass.
The Journal of clinical endocrinology and metabolism 1992;74(2):336-44.
1992: William S Evans; M J Sollenberger; R A Booth; Alan D Rogol; Randall J Urban; E C Carlsen; M L Johnson; Johannes D Veldhuis
Contemporary aspects of discrete peak-detection algorithms. II. The paradigm of the luteinizing hormone pulse signal in women.
Endocrine reviews 1992;13(1):81-104.
1992: Johannes D Veldhuis; G Lizarralde; Ali Iranmanesh
Divergent effects of short term glucocorticoid excess on the gonadotropic and somatotropic axes in normal men.
The Journal of clinical endocrinology and metabolism 1992;74(1):96-102.
1992: Johannes D Veldhuis; M L Johnson
Deconvolution analysis of hormone data.
Methods in enzymology 1992;210():539-75.
1991: Johannes D Veldhuis; J F Sotos; B M Sherman
Decreased metabolic clearance of endogenous growth hormone and specific alterations in the pulsatile mode of growth hormone secretion occur in prepubertal girls with Turner's syndrome. Genentech Collaborative Group.
The Journal of clinical endocrinology and metabolism 1991;73(5):1073-80.
1991: Randall J Urban; Vasantha Padmanabhan; IZ Beitins; Johannes D Veldhuis
Metabolic clearance of human follicle-stimulating hormone assessed by radioimmunoassay, immunoradiometric assay, and in vitro Sertoli cell bioassay.
The Journal of clinical endocrinology and metabolism 1991;73(4):818-23.
1991: J A Flores; Johannes D Veldhuis; D A Leong
Angiotensin II induces calcium release in a subpopulation of single ovarian (granulosa) cells.
Molecular and cellular endocrinology 1991;81(1-3):1-10.
1991: W C Nunley; Randall J Urban; William S Evans; Johannes D Veldhuis
Preservation of pulsatile luteinizing hormone release during postpartum lactational amenorrhea.
The Journal of clinical endocrinology and metabolism 1991;73(3):629-36.
1991: Johannes D Veldhuis; James C Garmey; Randall J Urban; L M Demers; B B Aggarwal
Ovarian actions of tumor necrosis factor-alpha (TNF alpha): pleiotropic effects of TNF alpha on differentiated functions of untransformed swine granulosa cells.
Endocrinology 1991;129(2):641-8.
1991: Johannes D Veldhuis; M L Johnson; W K Bolton
Analyzing pulsatile endocrine data in patients with chronic renal failure: a brief review of deconvolution techniques.
Pediatric nephrology (Berlin, Germany) 1991;5(4):522-8.
1991: Johannes D Veldhuis
Temporal architecture of in vivo endocrine glandular signaling: obtaining a secretory blueprint by deconvolution analysis.
Molecular and cellular endocrinology 1991;77(1-3):C63-71.
1991: R W Holl; Mark L Hartman; Johannes D Veldhuis; W M Taylor; Michael O Thorner
Thirty-second sampling of plasma growth hormone in man: correlation with sleep stages.
The Journal of clinical endocrinology and metabolism 1991;72(4):854-61.
1991: Randall J Urban; M L Johnson; Johannes D Veldhuis
In vivo biological validation and biophysical modeling of the sensitivity and positive accuracy of endocrine peak detection. II. The follicle-stimulating hormone pulse signal.
Endocrinology 1991;128(4):2008-14.
1991: Randall J Urban; James C Garmey; Margaret A Shupnik; Johannes D Veldhuis
Follicle-stimulating hormone increases concentrations of messenger ribonucleic acid encoding cytochrome P450 cholesterol side-chain cleavage enzyme in primary cultures of porcine granulosa cells.
Endocrinology 1991;128(4):2000-7.
1991: W C Nunley; Randall J Urban; J D Kitchin; B G Bateman; William S Evans; Johannes D Veldhuis
Dynamics of pulsatile prolactin release during the postpartum lactational period.
The Journal of clinical endocrinology and metabolism 1991;72(2):287-93.
1991: Mark L Hartman; A C Faria; Mary Lee Vance; M L Johnson; Michael O Thorner; Johannes D Veldhuis
Temporal structure of in vivo growth hormone secretory events in humans.
The American journal of physiology 1991;260(1 Pt 1):E101-10.
1991: Randall J Urban; Johannes D Veldhuis
A selective serotonin reuptake inhibitor, fluoxetine hydrochloride, modulates the pulsatile release of prolactin in postmenopausal women.
American journal of obstetrics and gynecology 1991;164(1 Pt 1):147-52.
1991: Johannes D Veldhuis; Ali Iranmanesh; K K Ho; M J Waters; M L Johnson; G Lizarralde
Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man.
The Journal of clinical endocrinology and metabolism 1991;72(1):51-9.
1991: Randall J Urban; K D Dahl; Vasantha Padmanabhan; I Z Beitins; Johannes D Veldhuis
Specific regulatory actions of dihydrotestosterone and estradiol on the dynamics of FSH secretion and clearance in humans.
Journal of andrology 1991;12(1):27-35.
1991: Johannes D Veldhuis; M L Johnson; M J Wilkowski; Ali Iranmanesh; W K Bolton
Neuroendocrine alterations in the somatotrophic axis in chronic renal failure.
Acta paediatrica Scandinavica. Supplement 1991;379():12-22; discussion 23.
1990: M J Sollenberger; E C Carlsen; Michael L Johnson; Johannes D Veldhuis; William S Evans
Specific physiological regulation of luteinizing hormone secretory events throughout the human menstrual cycle: new insights into the pulsatile mode of gonadotropin release.
Journal of neuroendocrinology 1990;2(6):845-52.
1990: Johannes D Veldhuis; Michael L Johnson
A Review and Appraisal of Deconvolution Methods to Evaluate in vivo Neuroendocrine Secretory Events.
Journal of neuroendocrinology 1990;2(6):755-71.
1990: Judy Y Weltman; Johannes D Veldhuis; Arthur Weltman; J R Kerrigan; William S Evans; Alan D Rogol
Reliability of estimates of pulsatile characteristics of luteinizing hormone and growth hormone release in women.
The Journal of clinical endocrinology and metabolism 1990;71(6):1646-52.
1990: J A Flores; Johannes D Veldhuis; D A Leong
Follicle-stimulating hormone evokes an increase in intracellular free calcium ion concentrations in single ovarian (granulosa) cells.
Endocrinology 1990;127(6):3172-9.
1990: Johannes D Veldhuis; Ali Iranmanesh; M L Johnson; G Lizarralde
Twenty-four-hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts.
The Journal of clinical endocrinology and metabolism 1990;71(6):1616-23.
1990: M J Sollenberger; E C Carlsen; R A Booth; M L Johnson; Johannes D Veldhuis; William S Evans
Nature of gonadotropin-releasing hormone self-priming of luteinizing hormone secretion during the normal menstrual cycle.
American journal of obstetrics and gynecology 1990;163(5 Pt 1):1529-34.
1990: Randall J Urban; James C Garmey; Margaret A Shupnik; Johannes D Veldhuis
Insulin-like growth factor type I increases concentrations of messenger ribonucleic acid encoding cytochrome P450 cholesterol side-chain cleavage enzyme in primary cultures of porcine granulosa cells.
Endocrinology 1990;127(5):2481-8.
1990: Ali Iranmanesh; G Lizarralde; D Short; Johannes D Veldhuis
Intensive venous sampling paradigms disclose high frequency adrenocorticotropin release episodes in normal men.
The Journal of clinical endocrinology and metabolism 1990;71(5):1276-83.
1990: Johannes D Veldhuis; A E Lassiter; M L Johnson
Operating behavior of dual or multiple endocrine pulse generators.
The American journal of physiology 1990;259(3 Pt 1):E351-61.
1990: Johannes D Veldhuis
The hypothalamic pulse generator: the reproductive core.
Clinical obstetrics and gynecology 1990;33(3):538-50.
1990: Michael O Thorner; Mary Lee Vance; Mark L Hartman; R W Holl; William S Evans; Johannes D Veldhuis; E Van Cauter; G Copinschi; Cyril Y Bowers
Physiological role of somatostatin on growth hormone regulation in humans.
Metabolism: clinical and experimental 1990;39(9 Suppl 2):40-2.
1990: Johannes D Veldhuis; Ali Iranmanesh; M L Johnson; G Lizarralde
Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man.
The Journal of clinical endocrinology and metabolism 1990;71(2):452-63.
1990: Judy Y Weltman; R L Seip; Arthur Weltman; D Snead; William S Evans; Johannes D Veldhuis; Alan D Rogol
Release of luteinizing hormone and growth hormone after recovery from maximal exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;69(1):196-200.
1990: Ali Iranmanesh; Johannes D Veldhuis; E C Carlsen; V A Vaccaro; R A Booth; G Lizarralde; C M Asplin; William S Evans
Attenuated pulsatile release of prolactin in men with insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1990;71(1):73-8.
1990: Johannes D Veldhuis; M L Johnson
An overview of computer algorithms for deconvolution-based assessment of in vivo neuroendocrine secretory events.
BioTechniques 1990;8(6):634-9.
1990: Mark L Hartman; Johannes D Veldhuis; Mary Lee Vance; A C Faria; R W Furlanetto; Michael O Thorner
Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy.
The Journal of clinical endocrinology and metabolism 1990;70(5):1375-84.
1990: Randall J Urban; Johannes D Veldhuis
Effects of short-term stimulation of serotoninergic pathways on the pulsatile secretion of luteinizing hormone in the absence and presence of acute opiate-receptor blockage.
Journal of andrology 1990;11(3):227-32.
1990: Randall J Urban; S N Pavlou; J E Rivier; W W Vale; M L Dufau; Johannes D Veldhuis
Suppressive actions of a gonadotropin-releasing hormone antagonist on luteinizing hormone, follicle-stimulating hormone, and prolactin release in estrogen-deficient postmenopausal women.
American journal of obstetrics and gynecology 1990;162(5):1255-60.
1990: Johannes D Veldhuis; M L Johnson; Ali Iranmanesh; G Lizarralde
Temporal structure of in vivo adrenal secretory activity estimated by deconvolution analysis.
Journal of biological rhythms 1990;5(3):247-55.
1990: Michael O Thorner; Mary Lee Vance; Alan D Rogol; R M Blizzard; Johannes D Veldhuis; E V Cauter; G Copinschi; Cyril Y Bowers
Growth hormone-releasing hormone and growth hormone-releasing peptide as potential therapeutic modalities.
Acta paediatrica Scandinavica. Supplement 1990;367():29-32.
1989: Johannes D Veldhuis; William S Evans; P G Stumpf
Mechanisms that subserve estradiol's induction of increased prolactin concentrations: evidence of amplitude modulation of spontaneous prolactin secretory bursts.
American journal of obstetrics and gynecology 1989;161(5):1149-58.
1989: M B Wheeler; Johannes D Veldhuis
Facilitative actions of the protein kinase-C effector system on hormonally stimulated adenosine 3',5'-monophosphate production by swine luteal cells.
Endocrinology 1989;125(5):2414-20.
1989: Johannes D Veldhuis; Randall J Urban; IZ Beitins; R M Blizzard; M L Johnson; M L Dufau
Pathophysiological features of the pulsatile secretion of biologically active luteinizing hormone in man.
Journal of steroid biochemistry 1989;33(4B):739-49.
1989: Johannes D Veldhuis
The estrogen-prolactinoma nexus in humans--fact or fable?
Mayo Clinic proceedings. Mayo Clinic 1989;64(9):1190-2.
1989: PM Martha; Alan D Rogol; Johannes D Veldhuis; J R Kerrigan; D W Goodman; R M Blizzard
Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys.
The Journal of clinical endocrinology and metabolism 1989;69(3):563-70.
1989: C M Asplin; A C Faria; E C Carlsen; V A Vaccaro; R E Barr; Ali Iranmanesh; M M Lee; Johannes D Veldhuis; William S Evans
Alterations in the pulsatile mode of growth hormone release in men and women with insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1989;69(2):239-45.
1989: Randall J Urban; M L Johnson; Johannes D Veldhuis
Biophysical modeling of sensitivity and positive accuracy of detecting episodic endocrine signals.
The American journal of physiology 1989;257(1 Pt 1):E88-94.
1989: Johannes D Veldhuis; Ali Iranmanesh; G Lizarralde; M L Johnson
Amplitude modulation of a burstlike mode of cortisol secretion subserves the circadian glucocorticoid rhythm.
The American journal of physiology 1989;257(1 Pt 1):E6-14.
1989: Johannes D Veldhuis; Ali Iranmanesh; L Clarke; D L Kaiser; Michael L Johnson
Random and Non-Random Coincidence Between Luteinizing Hormone Peaks and Follicle-Stimulating Hormone, Alpha Subunit, Prolactin and Gonadotropin-Releasing Hormone ulsations.
Journal of neuroendocrinology 1989;1(3):185-94.
1989: Johannes D Veldhuis; J T Gwynne
Insulin-like growth factor type I (somatomedin-C) stimulates high density lipoprotein (HDL) metabolism and HDL-supported progesterone biosynthesis by swine granulosa cells in vitro.
Endocrinology 1989;124(6):3069-76.
1989: Johannes D Veldhuis; L M Demers
Mechanism(s) by which activation of protein kinase C is coupled to prostacyclin synthesis in granulosa cells.
Molecular and cellular endocrinology 1989;63(1-2):219-26.
1989: Randall J Urban; M L Johnson; Johannes D Veldhuis
In vivo biological validation and biophysical modeling of the sensitivity and positive accuracy of endocrine peak detection. I. The LH pulse signal.
Endocrinology 1989;124(5):2541-7.
1989: Johannes D Veldhuis; S J Winters
Nature of alpha subunit secretion in men: circadian rhythms, pulsatile release and secretory profiles.
Journal of andrology 1989;10(3):248-58.
1989: Johannes D Veldhuis; L S O'Dea; M L Johnson
The nature of the gonadotropin-releasing hormone stimulus-luteinizing hormone secretory response of human gonadotrophs in vivo.
The Journal of clinical endocrinology and metabolism 1989;68(3):661-70.
1989: A C Faria; Johannes D Veldhuis; Michael O Thorner; Mary Lee Vance
Half-time of endogenous growth hormone (GH) disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin.
The Journal of clinical endocrinology and metabolism 1989;68(3):535-41.
1989: Johannes D Veldhuis; M L Johnson; M L Dufau
Physiological attributes of endogenous bioactive luteinizing hormone secretory bursts in man.
The American journal of physiology 1989;256(2 Pt 1):E199-207.
1989: Ali Iranmanesh; Johannes D Veldhuis; M L Johnson; G Lizarralde
24-hour pulsatile and circadian patterns of cortisol secretion in alcoholic men.
Journal of andrology 1989;10(1):54-63.
1989: M B Wheeler; Johannes D Veldhuis
Purification of three forms of chromatographically distinct protein kinase C from the swine ovary.
Molecular and cellular endocrinology 1989;61(1):117-22.
1988: Johannes D Veldhuis; M L Johnson
A novel general biophysical model for simulating episodic endocrine gland signaling.
The American journal of physiology 1988;255(6 Pt 1):E749-59.
1988: Randall J Urban; M R Davis; Alan D Rogol; M L Johnson; Johannes D Veldhuis
Acute androgen receptor blockade increases luteinizing hormone secretory activity in men.
The Journal of clinical endocrinology and metabolism 1988;67(6):1149-55.
1988: Johannes D Veldhuis
Management of amenorrhea.
Hospital practice (Office ed.) 1988;23(11A):40-7, 50-2, 55-6.
1988: M B Wheeler; Johannes D Veldhuis
Interactions of protein kinase C with receptor- and non-receptor-mediated cyclic AMP generation in swine granulosa cells.
Molecular and cellular endocrinology 1988;59(3):195-203.
1988: Johannes D Veldhuis
Follicle-stimulating hormone regulates low density lipoprotein metabolism by swine granulosa cells.
Endocrinology 1988;123(3):1660-7.
1988: Johannes D Veldhuis; M L Johnson
Operating characteristics of the hypothalamo-pituitary-gonadal axis in men: circadian, ultradian, and pulsatile release of prolactin and its temporal coupling with luteinizing hormone.
The Journal of clinical endocrinology and metabolism 1988;67(1):116-23.
1988: Johannes D Veldhuis; M L Johnson
In vivo dynamics of luteinizing hormone secretion and clearance in man: assessment by deconvolution mechanics.
The Journal of clinical endocrinology and metabolism 1988;66(6):1291-300.
1988: Johannes D Veldhuis; Raymond Rodgers; Erik L Hewlett
Actions of cyclic adenosine monophosphate on the cytodifferentiation of ovarian cells: studies in cultured swine granulosa cells using a novel exogenous adenylate cyclase from Bordetella pertussis.
Molecular endocrinology (Baltimore, Md.) 1988;2(6):499-506.
1988: Ali Iranmanesh; Johannes D Veldhuis; E Samojlik; A D Rogol; M L Johnson; G Lizarralde
Alterations in the pulsatile properties of gonadotropin secretion in alcoholic men.
Journal of andrology 1988;9(3):207-14.
1988: Randall J Urban; Johannes D Veldhuis; R M Blizzard; M L Dufau
Attenuated release of biologically active luteinizing hormone in healthy aging men.
The Journal of clinical investigation 1988;81(4):1020-9.
1988: K Y Ho; Johannes D Veldhuis; M L Johnson; R Furlanetto; William S Evans; K G Alberti; Michael O Thorner
Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.
The Journal of clinical investigation 1988;81(4):968-75.
1988: Johannes D Veldhuis; William S Evans; Randall J Urban; A D Rogol; M L Johnson
Physiologic attributes of the luteinizing hormone pulse signal in the human. Cross-validation studies in men.
Journal of andrology 1988;9(2):69-77.
1988: Johannes D Veldhuis; E Christiansen; William S Evans; LISA KOLP; Alan D Rogol; M L Johnson
Physiological profiles of episodic progesterone release during the midluteal phase of the human menstrual cycle: analysis of circadian and ultradian rhythms, discrete pulse properties, and correlations with simultaneous luteinizing hormone release.
The Journal of clinical endocrinology and metabolism 1988;66(2):414-21.
1988: Randall J Urban; William S Evans; Alan D Rogol; D L Kaiser; M L Johnson; Johannes D Veldhuis
Contemporary aspects of discrete peak-detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men.
Endocrine reviews 1988;9(1):3-37.
1988: Randall J Urban; D L Kaiser; E van Cauter; M L Johnson; Johannes D Veldhuis
Comparative assessments of objective peak-detection algorithms. II. Studies in men.
The American journal of physiology 1988;254(1 Pt 1):E113-9.
1988: Johannes D Veldhuis; A Faria; Mary Lee Vance; William S Evans; Michael O Thorner; M L Johnson
Contemporary tools for the analysis of episodic growth hormone secretion and clearance in vivo.
Acta paediatrica Scandinavica. Supplement 1988;347():63-82.
1987: Johannes D Veldhuis
Prostaglandin F2 alpha initiates polyphosphatidylinositol hydrolysis and membrane translocation of protein kinase C in swine ovarian cells.
Biochemical and biophysical research communications 1987;149(1):112-7.
1987: Johannes D Veldhuis; J C King; Randall J Urban; Alan D Rogol; William S Evans; LISA KOLP; M L Johnson
Operating characteristics of the male hypothalamo-pituitary-gonadal axis: pulsatile release of testosterone and follicle-stimulating hormone and their temporal coupling with luteinizing hormone.
The Journal of clinical endocrinology and metabolism 1987;65(5):929-41.
1987: Johannes D Veldhuis; M L Carlson; M L Johnson
The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7686-90.
1987: Johannes D Veldhuis
Pathophysiologic features of episodic gonadotropin secretion in man.
The American journal of the medical sciences 1987;294(3):150-60.
1987: Johannes D Veldhuis; L M Demers
Activation of protein kinase C is coupled to prostaglandin E2 synthesis in swine granulosa cells.
Prostaglandins 1987;33(6):819-29.