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Murielle Véniant

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Richard Smith; Stephen Smith; Jennitte Stevens; Melissa R Thomas; Murielle Véniant; Jennifer Weiszmann; Xinle Wu; Li Yang; Benjamin M Alba; Alice Bakker; Jiyun Chen; Amy Duguay; Jamila Gupte; Agnes Hamburger; Renee Komorowski; Peng Li; Kevin W Moore; Yang Li
FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein.
Murielle Véniant; Russell Wada; Katherine Winters; Ping Chen; Todd Hager; Randy Hecht; Renee Komorowski; Shanaka Stanislaus; Lei Zhou; Jing Xu
Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys.
Shu-Chen Lu; Murielle Véniant; Ki Won Kim; Larissa Atangan; Michelle M Chen; Carolyn Chu; Wei Gu; Joon Han; Sylvia Hu; Renee Komorowski; Minghan Wang
An apoA-I mimetic peptibody generates HDL-like particles and increases alpha-1 HDL subfraction in mice.

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All Publications

2013: Richard Smith; Stephen Smith; Jennitte Stevens; Melissa R Thomas; Murielle Véniant; Jennifer Weiszmann; Xinle Wu; Li Yang; Benjamin M Alba; Alice Bakker; Jiyun Chen; Amy Duguay; Jamila Gupte; Agnes Hamburger; Renee Komorowski; Peng Li; Kevin W Moore; Yang Li
FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein.
PloS one 2013;8(4):e61432.
2012: Murielle Véniant; Russell Wada; Katherine Winters; Ping Chen; Todd Hager; Randy Hecht; Renee Komorowski; Shanaka Stanislaus; Lei Zhou; Jing Xu
Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys.
Endocrinology 2012;153(9):4192-203.
2012: Shu-Chen Lu; Murielle Véniant; Ki Won Kim; Larissa Atangan; Michelle M Chen; Carolyn Chu; Wei Gu; Joon Han; Sylvia Hu; Renee Komorowski; Minghan Wang
An apoA-I mimetic peptibody generates HDL-like particles and increases alpha-1 HDL subfraction in mice.
Journal of lipid research 2012;53(4):643-52.
2012: Junming Yie; Wei Wang; Jing Xu; Ching Chen; Michelle M Chen; Liying Deng; Randy Hecht; Yang Li; Richard Lindberg; Jennitte Stevens; Lei-Ting Tam; Murielle Véniant; Minghan Wang
Understanding the physical interactions in the FGF21/FGFR/β-Klotho complex: structural requirements and implications in FGF21 signaling.
Chemical biology & drug design 2012;79(4):398-410.
2012: Randy Hecht; Yvonne Lau; Yue-Sheng Li; Mark Leo Michaels; Zhongnan Shen; Allen Sickmier; Stephen Smith; Chris Spahr; Shanaka Stanislaus; Jeonghoon Sun; Lei-Ting Tam; Murielle Véniant; Wei Wang; Dwight Winters; Ed Belouski; Thomas Boone; Narumol Chinookoswong; Todd Hager; Michael Hall; Junming Yie; Jing Xu
Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes.
PloS one 2012;7(11):e49345.
2012: Murielle Véniant; Steven Vonderfecht; Jing Xu; Shanaka Stanislaus; Jim Busby; Michelle M Chen; Clarence Hale; Joan Helmering; David J Lloyd
FGF21 promotes metabolic homeostasis via white adipose and leptin in mice.
PloS one 2012;7(7):e40164.
2011: David J Lloyd; Joan Helmering; Stephen A Kaufman; James Turk; Matt Silva; Sergio Vasquez; David Weinstein; Brad Johnston; Clarence Hale; Murielle Véniant
A volumetric method for quantifying atherosclerosis in mice by using microCT: comparison to en face.
PloS one 2011;6(4):e18800.
2009: Jing Xu; Jen Weiszmann; Jim Busby; Narumol Chinookoswong; Hongfei Ge; Melissa Graham; Todd Hager; Randy Hecht; Yvonne Y Lau; Yang Li; Yue-Sheng Li; Richard Lindberg; Shu-Chen Lu; Jennifer Patel; Shanaka Stanislaus; Murielle Véniant
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.
American journal of physiology. Endocrinology and metabolism 2009;297(5):E1105-14.
2009: D J Lloyd; J Helmering; D Cordover; M Bowsman; Michelle Chen; Clarence Hale; P Fordstrom; M Zhou; Minghan Wang; S A Kaufman; Murielle Véniant
Antidiabetic effects of 11beta-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis.
Diabetes, obesity & metabolism 2009;11(7):688-99.
2009: Shu-Chen Lu; Jing Xu; Narumol Chinookoswong; Shuying Liu; Shirley Steavenson; Colin Gegg; David Brankow; Richard Lindberg; Murielle Véniant; Wei Gu
An acyl-ghrelin-specific neutralizing antibody inhibits the acute ghrelin-mediated orexigenic effects in mice.
Molecular pharmacology 2009;75(4):901-7.
2009: Todd Juan; Murielle Véniant; Joan Helmering; Philip Babij; Daniel M Baker; Michael A Damore; Michael B Bass; Tibor Gyuris; Mark Chhoa; Chi-Ming Li; Chris Ebeling; Julie Amato; George A Carlson; David J Lloyd
Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice.
Journal of lipid research 2009;50(3):534-45.
2009: Murielle Véniant; Clarence Hale; R Komorowski; M M Chen; D J St Jean; Christopher Fotsch; Minghan Wang
Time of the day for 11beta-HSD1 inhibition plays a role in improving glucose homeostasis in DIO mice.
Diabetes, obesity & metabolism 2009;11(2):109-17.
2009: Junming Yie; Randy Hecht; Jennifer Patel; Jennitte Stevens; Wei Wang; Nessa Hawkins; Shirley Steavenson; Steve Smith; Dwight Winters; Seth Fisher; Ling Cai; Ed Belouski; Ching Chen; Mark L Michaels; Yue-Sheng Li; Richard Lindberg; Minghan Wang; Murielle Véniant; Jing Xu
FGF21 N- and C-termini play different roles in receptor interaction and activation.
FEBS letters 2009;583(1):19-24.
2009: Abraham A Anderson; Joan Helmering; Todd Juan; Chi-Ming Li; Jocelyn McCormick; Melissa Graham; Daniel M Baker; Michael A Damore; Murielle Véniant; David J Lloyd
Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt.
PathoGenetics 2009;2(1):1.
2008: Christopher Fotsch; Michael D Bartberger; Eric A Bercot; Michelle Chen; Rod Cupples; Maury Emery; Jenne Fretland; Anil Guram; Clarence Hale; Nianhe Han; Dean Hickman; Randall W Hungate; Michael Hayashi; Renee Komorowski; Qingyian Liu; Guy Matsumoto; David J St Jean; Stefania Ursu; Murielle Véniant; Guifen Xu; Qiuping Ye; Chester Yuan; Jiandong Zhang; Xiping Zhang; Hua Tu; Minghan Wang
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.
Journal of medicinal chemistry 2008;51(24):7953-67.
2008: Ki Won Kim; Jocelyn McCormick; Joan Helmering; Murielle Véniant; Minghan Wang
An optimized fast-performance liquid chromatography method for analyzing lipoprotein profiles using microliter volumes of serum.
Analytical biochemistry 2008;376(2):268-74.
2008: Clarence Hale; Murielle Véniant; Zhulun Wang; Michelle Chen; Jocelyn McCormick; Rod Cupples; Dean Hickman; Xiaoshan Min; Athena Sudom; Haoda Xu; Guy Matsumoto; Christopher Fotsch; David J St Jean; Minghan Wang
Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.
Chemical biology & drug design 2008;71(1):36-44.
2004: Aaron E Cozen; Hideaki Moriwaki; Michal Kremen; Mary Beth DeYoung; Helén L Dichek; Katherine I Slezicki; Stephen G Young; Murielle Véniant; David A Dichek
Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death.
Circulation 2004;109(17):2129-35.
2001: J Bjorkegren; Murielle Véniant; SK Kim; Shannon K Withycombe; P A Wood; Marc K Hellerstein; Richard A Neese; Stephen G Young
Lipoprotein secretion and triglyceride stores in the heart.
The Journal of biological chemistry 2001;276(42):38511-7.
2001: Murielle Véniant; Shannon K Withycombe; Stephen G Young
Lipoprotein size and atherosclerosis susceptibility in Apoe(-/-) and Ldlr(-/-) mice.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(10):1567-70.
2000: Murielle Véniant; M A Sullivan; SK Kim; Patricia Ambroziak; A Chu; M D Wilson; Marc K Hellerstein; Lawrence L Rudel; Rosemary Walzem; Stephen G Young
Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100.
The Journal of clinical investigation 2000;106(12):1501-10.
2000: GK Leung; Murielle Véniant; SK Kim; CH Zlot; M Raabe; Johan Björkegren; Richard A Neese; Marc K Hellerstein; Stephen G Young
A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion.
The Journal of biological chemistry 2000;275(11):7515-20.
1999: M Raabe; Murielle Véniant; M A Sullivan; CH Zlot; Johan Björkegren; Lars B Nielsen; Jinny S Wong; Robert L Hamilton; Stephen G Young
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice.
The Journal of clinical investigation 1999;103(9):1287-98.
1999: Murielle Véniant; Lars B Nielsen; Jan Borén; Stephen G Young
Lipoproteins containing apolipoprotein B-100 are secreted by the heart.
Trends in cardiovascular medicine 1999;9(3-4):103-7.
1999: Murielle Véniant; Edward Kim; S McCormick; Jan Borén; Lars B Nielsen; M Raabe; Stephen G Young
Insights into apolipoprotein B biology from transgenic and gene-targeted mice.
The Journal of nutrition 1999;129(2S Suppl):451S-455S.
1999: CH Zlot; LM Flynn; Murielle Véniant; Edward Kim; M Raabe; Sally P A McCormick; Patricia Ambroziak; L M McEvoy; Stephen G Young
Generation of monoclonal antibodies specific for mouse apolipoprotein B-100 in apolipoprotein B-48-only mice.
Journal of lipid research 1999;40(1):76-84.
1998: Edward Kim; Patricia Ambroziak; Murielle Véniant; Robert L Hamilton; Stephen G Young
A gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B gene.
The Journal of biological chemistry 1998;273(51):33977-84.
1998: M Raabe; Edward Kim; Murielle Véniant; Lars B Nielsen; Stephen G Young
Using genetically engineered mice to understand apolipoprotein-B deficiency syndromes in humans.
Proceedings of the Association of American Physicians 1998;110(6):521-30.
1998: Murielle Véniant; CH Zlot; Rosemary Walzem; V Pierotti; Robert Driscoll; David A Dichek; Joachim Herz; Stephen G Young
Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice.
The Journal of clinical investigation 1998;102(8):1559-68.
1998: Lyn Powell-Braxton; Murielle Véniant; R D Latvala; K I Hirano; Wesley Won; Jed Ross; N Dybdal; Constance Zlot; Stephen G Young; N O Davidson
A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet.
Nature medicine 1998;4(8):934-8.
1998: M Raabe; LM Flynn; CH Zlot; Jinny S Wong; Murielle Véniant; Robert L Hamilton; Stephen G Young
Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8686-91.
1998: Lars B Nielsen; Murielle Véniant; Jan Borén; M Raabe; Jinny S Wong; Carmen Tam-Amersdorfer; LM Flynn; TM Vanni-Reyes; MD Gunn; I J Goldberg; Robert L Hamilton; Stephen G Young
Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins.
Circulation 1998;98(1):13-6.
1998: Edward Kim; CM Cham; Murielle Véniant; Patricia Ambroziak; Stephen G Young
Dual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob gene.
The Journal of clinical investigation 1998;101(6):1468-77.
1998: Jan Borén; Murielle Véniant; Stephen G Young
Apo B100-containing lipoproteins are secreted by the heart.
The Journal of clinical investigation 1998;101(6):1197-202.
1997: Murielle Véniant; V Pierotti; DL Newland; CM Cham; David A Sanan; Rosemary Walzem; Stephen G Young
Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.
The Journal of clinical investigation 1997;100(1):180-8.
1996: Robert V Farese; Murielle Véniant; CM Cham; L M Flynn; V Pierotti; Jeanne F Loring; M Traber; S Ruland; R S Stokowski; D Huszar; Stephen G Young
Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6393-8.
1996: Sally P A McCormick; J K Ng; Murielle Véniant; Jan Borén; V Pierotti; L M Flynn; D S Grass; Stephen G Young
Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene.
The Journal of biological chemistry 1996;271(20):11963-70.