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R Venkataraman

Research Profile

Chemicals & Drugs

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TOP 3
Dengfeng Dou; Guijia He; R Kuang; Qingfong Fu; R Venkataraman; William C Groutas
Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase.
William C Groutas; Jeff B Epp; R Kuang; S Ruan; L S Chong; R Venkataraman; Juan Tu; S He; Hongyi Yu; Q Fu; Yue H Li; TM Truong; N T Vu
1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases.
S He; R Kuang; R Venkataraman; Juan Tu; TM Truong; H K Chan; William C Groutas
Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide.

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All Publications

2010: Dengfeng Dou; Guijia He; R Kuang; Qingfong Fu; R Venkataraman; William C Groutas
Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase.
Bioorganic & medicinal chemistry 2010;18(18):6646-50.
2001: William C Groutas; Jeff B Epp; R Kuang; S Ruan; L S Chong; R Venkataraman; Juan Tu; S He; Hongyi Yu; Q Fu; Yue H Li; TM Truong; N T Vu
1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases.
Archives of biochemistry and biophysics 2001;385(1):162-9.
2000: S He; R Kuang; R Venkataraman; Juan Tu; TM Truong; H K Chan; William C Groutas
Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide.
Bioorganic & medicinal chemistry 2000;8(7):1713-7.
2000: R Kuang; Jeff B Epp; S Ruan; L S Chong; R Venkataraman; Juan Tu; S He; TM Truong; William C Groutas
Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates.
Bioorganic & medicinal chemistry 2000;8(5):1005-16.
1998: William C Groutas; R Kuang; S Ruan; Jeff B Epp; R Venkataraman; TM Truong
Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold.
Bioorganic & medicinal chemistry 1998;6(6):661-71.
1998: R Kuang; R Venkataraman; S Ruan; William C Groutas
Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases.
Bioorganic & medicinal chemistry letters 1998;8(5):539-44.
1997: William C Groutas; R Kuang; R Venkataraman; Jeff B Epp; S Ruan; O Prakash
Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold.
Biochemistry 1997;36(16):4739-50.
1996: William C Groutas; Jeff B Epp; R Venkataraman; R Kuang; T M Truong; J J McClenahan; O Prakash
Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners.
Bioorganic & medicinal chemistry 1996;4(9):1393-400.
1996: William C Groutas; L S Chong; R Venkataraman; R Kuang; Jeff B Epp; N Houser-Archield; H Huang; John R Hoidal
Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3.
Archives of biochemistry and biophysics 1996;332(2):335-40.
1995: William C Groutas; M J Brubaker; L S Chong; R Venkataraman; H Huang; Jeff B Epp; R Kuang; John R Hoidal
Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.
Bioorganic & medicinal chemistry 1995;3(4):375-81.
1995: William C Groutas; L S Chong; R Venkataraman; Jeff B Epp; R Kuang; N Houser-Archield; John R Hoidal
The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.
Bioorganic & medicinal chemistry 1995;3(2):187-93.
1995: William C Groutas; R Venkataraman; L S Chong; J E Yoder; Jeff B Epp; M A Stanga; E H Kim
Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study.
Bioorganic & medicinal chemistry 1995;3(2):125-8.
1994: William C Groutas; H Huang; Jeff B Epp; R Venkataraman; J J McClenahan; F Tagusagawa
Mechanism-based inhibition of human leukocyte elastase and cathepsin G by substituted dihydrouracils.
Biochimica et biophysica acta 1994;1227(3):130-6.
1994: William C Groutas; R Kuang; R Venkataraman
Substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides: a new class of potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G.
Biochemical and biophysical research communications 1994;198(1):341-9.
1993: William C Groutas; L S Chong; R Venkataraman
Novel potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G: derivatives of isothiazolidin-3-one.
Biochemical and biophysical research communications 1993;197(2):730-9.
1993: William C Groutas; N Houser-Archield; L S Chong; R Venkataraman; Jeff B Epp; H Huang; J J McClenahan
Efficient inhibition of human leukocyte elastase and cathepsin G by saccharin derivatives.
Journal of medicinal chemistry 1993;36(21):3178-81.
1993: William C Groutas; H Huang; R Venkataraman; N Houser-Archield; Jeff B Epp
Dual-action inhibitors of proteolytic enzymes: potential therapeutic agents for cystic fibrosis and related ailments.
Bioorganic & medicinal chemistry 1993;1(4):273-7.
1993: William C Groutas; L S Chong; R Venkataraman; Jeff B Epp; R Kuang; M J Brubaker; N Houser-Archield; H Huang; J J McClenahan
Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement.
Biochemical and biophysical research communications 1993;194(3):1491-9.
1993: William C Groutas; R Venkataraman; M J Brubaker; Jeff B Epp; L S Chong; M A Stanga; J J McClenahan; F Tagusagawa
3-(Alkylthio)-N-hydroxysuccinimide derivatives: potent inhibitors of human leukocyte elastase.
Biochimica et biophysica acta 1993;1164(3):283-8.
1992: William C Groutas; M J Brubaker; R Venkataraman; M A Stanga
Enantioselective inhibition of human leukocyte elastase.
Archives of biochemistry and biophysics 1992;297(1):144-6.
1992: William C Groutas; M J Brubaker; R Venkataraman; Jeff B Epp; M A Stanga; J J McClenahan
Inhibitors of human neutrophil cathepsin G: structural and biochemical studies.
Archives of biochemistry and biophysics 1992;294(1):144-6.
1991: William C Groutas; R Venkataraman; M J Brubaker; M A Stanga
Inhibition of human leukocyte elastase by phosphate esters of N-hydroxysuccinimide and its derivatives: direct observation of a phosphorylated enzyme by 31P nuclear magnetic resonance spectroscopy.
Biochemistry 1991;30(17):4132-6.
1990: William C Groutas; John R Hoidal; M J Brubaker; M A Stanga; R Venkataraman; B H Gray; Narayanam V Rao
Inhibitors of human leukocyte proteinase-3.
Journal of medicinal chemistry 1990;33(4):1085-7.